metyrapone has been researched along with Adrenocortical Carcinoma in 8 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Adrenocortical Carcinoma: A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mitotane is the reference drug for adrenocortical carcinoma (ACC) and the metabolic activation of the drug is considered as essential for its activity." | 7.88 | CYP11B1 has no role in mitotane action and metabolism in adrenocortical carcinoma cells. ( Berruti, A; De Francia, S; Germano, A; Perotti, P; Rapa, I; Saba, L; Terzolo, M; Volante, M, 2018) |
| "Mitotane is the reference drug for adrenocortical carcinoma (ACC) and the metabolic activation of the drug is considered as essential for its activity." | 3.88 | CYP11B1 has no role in mitotane action and metabolism in adrenocortical carcinoma cells. ( Berruti, A; De Francia, S; Germano, A; Perotti, P; Rapa, I; Saba, L; Terzolo, M; Volante, M, 2018) |
| "The human adrenocortical carcinoma cell line H295R is being used as an in vitro steroidogenesis screening assay to assess the impact of endocrine active chemicals (EACs) capable of altering steroid biosynthesis." | 1.37 | Mechanistic computational model of steroidogenesis in H295R cells: role of oxysterols and cell proliferation to improve predictability of biochemical response to endocrine active chemical--metyrapone. ( Breen, M; Breen, MS; Conolly, RB; Lloyd, AL; Terasaki, N; Yamazaki, M, 2011) |
| "Cushing syndrome was diagnosed on the basis of a markedly elevated 24-hour urine free cortisol level and classic cushingoid features." | 1.35 | A patient with ectopic cortisol production derived from malignant testicular masses. ( Dluhy, RG; Jain, SH; Nosé, V; Sadow, PM, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Claps, M | 1 |
| Cerri, S | 1 |
| Grisanti, S | 1 |
| Lazzari, B | 1 |
| Ferrari, V | 1 |
| Roca, E | 1 |
| Perotti, P | 2 |
| Terzolo, M | 2 |
| Sigala, S | 1 |
| Berruti, A | 2 |
| Germano, A | 1 |
| Saba, L | 1 |
| De Francia, S | 1 |
| Rapa, I | 1 |
| Volante, M | 1 |
| Syed, AA | 1 |
| Demssi, YN | 1 |
| Corcuff, JB | 1 |
| Young, J | 1 |
| Masquefa-Giraud, P | 1 |
| Chanson, P | 1 |
| Baudin, E | 1 |
| Tabarin, A | 1 |
| Jain, SH | 1 |
| Sadow, PM | 1 |
| Nosé, V | 1 |
| Dluhy, RG | 1 |
| Breen, M | 1 |
| Breen, MS | 1 |
| Terasaki, N | 1 |
| Yamazaki, M | 1 |
| Lloyd, AL | 1 |
| Conolly, RB | 1 |
| DANIELS, H | 1 |
| SCHOPMAN, W | 1 |
| WEST, CD | 1 |
| KUMAGAI, LF | 1 |
| SIMONS, EL | 1 |
| DOMINGUEZ, OB | 1 |
| BERLINER, DL | 1 |
8 other studies available for metyrapone and Adrenocortical Carcinoma
| Article | Year |
|---|---|
Adding metyrapone to chemotherapy plus mitotane for Cushing's syndrome due to advanced adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Aged; Antimetabolites, Antineoplastic; An | 2018 |
CYP11B1 has no role in mitotane action and metabolism in adrenocortical carcinoma cells.
Topics: Adrenocortical Carcinoma; Antineoplastic Agents, Hormonal; Cell Line, Tumor; Cell Proliferation; Hum | 2018 |
Medical image. Adrenocortical carcinoma presenting with hirsutism: an uncommon cause of a common complaint.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Antimetabolites; Diagnosis, Differential; Fatal | 2014 |
Rapid control of severe neoplastic hypercortisolism with metyrapone and ketoconazole.
Topics: ACTH Syndrome, Ectopic; Adrenal Gland Neoplasms; Adrenocortical Carcinoma; Adult; Aged; Cushing Synd | 2015 |
A patient with ectopic cortisol production derived from malignant testicular masses.
Topics: Adrenal Rest Tumor; Adrenocortical Carcinoma; Adrenocorticotropic Hormone; Aged; Cushing Syndrome; H | 2008 |
Mechanistic computational model of steroidogenesis in H295R cells: role of oxysterols and cell proliferation to improve predictability of biochemical response to endocrine active chemical--metyrapone.
Topics: Adrenocortical Carcinoma; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cholesterol; Computat | 2011 |
EFFECT OF METOPIRONE IN A PATIENT WITH ADRENAL CORTICAL CARCINOMA.
Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenocortical Carcinoma; Cushing | 1963 |
ADRENOCORTICAL CARCINOMA WITH FEMINIZATION AND HYPERTENSION ASSOCIATED WITH A DEFECT IN 11-BETA-HYDROXYLATION.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acne Vulgaris; Adrenal Cortex Hormones; Adrenal Gland Ne | 1964 |