Page last updated: 2024-10-31

metyrapone and Adrenocortical Carcinoma

metyrapone has been researched along with Adrenocortical Carcinoma in 8 studies

Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.

Adrenocortical Carcinoma: A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.

Research Excerpts

ExcerptRelevanceReference
"Mitotane is the reference drug for adrenocortical carcinoma (ACC) and the metabolic activation of the drug is considered as essential for its activity."7.88CYP11B1 has no role in mitotane action and metabolism in adrenocortical carcinoma cells. ( Berruti, A; De Francia, S; Germano, A; Perotti, P; Rapa, I; Saba, L; Terzolo, M; Volante, M, 2018)
"Mitotane is the reference drug for adrenocortical carcinoma (ACC) and the metabolic activation of the drug is considered as essential for its activity."3.88CYP11B1 has no role in mitotane action and metabolism in adrenocortical carcinoma cells. ( Berruti, A; De Francia, S; Germano, A; Perotti, P; Rapa, I; Saba, L; Terzolo, M; Volante, M, 2018)
"The human adrenocortical carcinoma cell line H295R is being used as an in vitro steroidogenesis screening assay to assess the impact of endocrine active chemicals (EACs) capable of altering steroid biosynthesis."1.37Mechanistic computational model of steroidogenesis in H295R cells: role of oxysterols and cell proliferation to improve predictability of biochemical response to endocrine active chemical--metyrapone. ( Breen, M; Breen, MS; Conolly, RB; Lloyd, AL; Terasaki, N; Yamazaki, M, 2011)
"Cushing syndrome was diagnosed on the basis of a markedly elevated 24-hour urine free cortisol level and classic cushingoid features."1.35A patient with ectopic cortisol production derived from malignant testicular masses. ( Dluhy, RG; Jain, SH; Nosé, V; Sadow, PM, 2008)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19902 (25.00)18.7374
1990's0 (0.00)18.2507
2000's1 (12.50)29.6817
2010's5 (62.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Claps, M1
Cerri, S1
Grisanti, S1
Lazzari, B1
Ferrari, V1
Roca, E1
Perotti, P2
Terzolo, M2
Sigala, S1
Berruti, A2
Germano, A1
Saba, L1
De Francia, S1
Rapa, I1
Volante, M1
Syed, AA1
Demssi, YN1
Corcuff, JB1
Young, J1
Masquefa-Giraud, P1
Chanson, P1
Baudin, E1
Tabarin, A1
Jain, SH1
Sadow, PM1
Nosé, V1
Dluhy, RG1
Breen, M1
Breen, MS1
Terasaki, N1
Yamazaki, M1
Lloyd, AL1
Conolly, RB1
DANIELS, H1
SCHOPMAN, W1
WEST, CD1
KUMAGAI, LF1
SIMONS, EL1
DOMINGUEZ, OB1
BERLINER, DL1

Other Studies

8 other studies available for metyrapone and Adrenocortical Carcinoma

ArticleYear
Adding metyrapone to chemotherapy plus mitotane for Cushing's syndrome due to advanced adrenocortical carcinoma.
    Endocrine, 2018, Volume: 61, Issue:1

    Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Aged; Antimetabolites, Antineoplastic; An

2018
CYP11B1 has no role in mitotane action and metabolism in adrenocortical carcinoma cells.
    PloS one, 2018, Volume: 13, Issue:5

    Topics: Adrenocortical Carcinoma; Antineoplastic Agents, Hormonal; Cell Line, Tumor; Cell Proliferation; Hum

2018
Medical image. Adrenocortical carcinoma presenting with hirsutism: an uncommon cause of a common complaint.
    The New Zealand medical journal, 2014, Mar-07, Volume: 127, Issue:1390

    Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Antimetabolites; Diagnosis, Differential; Fatal

2014
Rapid control of severe neoplastic hypercortisolism with metyrapone and ketoconazole.
    European journal of endocrinology, 2015, Volume: 172, Issue:4

    Topics: ACTH Syndrome, Ectopic; Adrenal Gland Neoplasms; Adrenocortical Carcinoma; Adult; Aged; Cushing Synd

2015
A patient with ectopic cortisol production derived from malignant testicular masses.
    Nature clinical practice. Endocrinology & metabolism, 2008, Volume: 4, Issue:12

    Topics: Adrenal Rest Tumor; Adrenocortical Carcinoma; Adrenocorticotropic Hormone; Aged; Cushing Syndrome; H

2008
Mechanistic computational model of steroidogenesis in H295R cells: role of oxysterols and cell proliferation to improve predictability of biochemical response to endocrine active chemical--metyrapone.
    Toxicological sciences : an official journal of the Society of Toxicology, 2011, Volume: 123, Issue:1

    Topics: Adrenocortical Carcinoma; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cholesterol; Computat

2011
EFFECT OF METOPIRONE IN A PATIENT WITH ADRENAL CORTICAL CARCINOMA.
    Acta endocrinologica, 1963, Volume: 44

    Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenocortical Carcinoma; Cushing

1963
ADRENOCORTICAL CARCINOMA WITH FEMINIZATION AND HYPERTENSION ASSOCIATED WITH A DEFECT IN 11-BETA-HYDROXYLATION.
    The Journal of clinical endocrinology and metabolism, 1964, Volume: 24

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acne Vulgaris; Adrenal Cortex Hormones; Adrenal Gland Ne

1964