metyrapone has been researched along with Adrenal Hyperplasia, Congenital in 42 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Adrenal Hyperplasia, Congenital: A group of inherited disorders of the ADRENAL GLANDS, caused by enzyme defects in the synthesis of cortisol (HYDROCORTISONE) and/or ALDOSTERONE leading to accumulation of precursors for ANDROGENS. Depending on the hormone imbalance, congenital adrenal hyperplasia can be classified as salt-wasting, hypertensive, virilizing, or feminizing. Defects in STEROID 21-HYDROXYLASE; STEROID 11-BETA-HYDROXYLASE; STEROID 17-ALPHA-HYDROXYLASE; 3-beta-hydroxysteroid dehydrogenase (3-HYDROXYSTEROID DEHYDROGENASES); TESTOSTERONE 5-ALPHA-REDUCTASE; or steroidogenic acute regulatory protein; among others, underlie these disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We present a case of McCune-Albright syndrome revealed by a Cushing's syndrome treated by metyrapone." | 7.73 | [Treatment with metyrapone of Cushing's syndrome revealing McCune-Albright syndrome]. ( Azzabi, O; Ben Ammar, B; Ben Hariz, M; Ben Mrad, N; Halioui-Louhaichi, S; Maherzi, A; Nefzi, L, 2005) |
| "We present a case of McCune-Albright syndrome revealed by a Cushing's syndrome treated by metyrapone." | 3.73 | [Treatment with metyrapone of Cushing's syndrome revealing McCune-Albright syndrome]. ( Azzabi, O; Ben Ammar, B; Ben Hariz, M; Ben Mrad, N; Halioui-Louhaichi, S; Maherzi, A; Nefzi, L, 2005) |
| " by metyrapone test or by congenital adrenal hyperplasia resulting from 11 beta-hydroxylase deficiency." | 3.69 | An alternate pathway to androstenedione synthesis by human adrenals: evidence of a balance in 11 beta-hydroxylase and 17,20-lyase activities leading to androstenedione. ( Auzéby, A; Bogdan, A; Touitou, Y, 1995) |
| " In congenital adrenal hyperplasia, plasma ACTH concentrations mirror, together with 17-alpha-hydroxyprogesterone, the extent of ACTH suppression." | 3.67 | Plasma ACTH in diagnosis and control of adrenal disorders. ( Baumann, JB; Eberle, AN; Girard, J, 1986) |
| "Serum androgen levels, including dehydroepiandrosterone sulphate (DHAS) which is thought to be solely of adrenal origin, are elevated in women with the polycystic ovarian syndrome." | 3.66 | Acth function in women with the polycystic ovarian syndrome. ( Butt, WR; Holder, G; Horrocks, PM; Kandeel, FR; Logan-Edwards, R; London, DR; Lynch, SS, 1983) |
| "Non-iatrogenic Cushing's syndrome has been associated primarily with three entities: pituitary-dependent processes due to pituitary adenomas or microadenomas causing adrenal hyperplasia; pituitary-independent primary adrenal causes, predominantly unilateral adenomas, rarely multiple adenomas or adrenal carcinoma; ectopic sources of adrenocorticotropic hormone (ACTH) production." | 2.37 | Primary adrenocortical nodular dysplasia, a distinct subtype of Cushing's syndrome. Case report and review of the literature. ( Cathey, WJ; Larsen, JL; Odell, WD, 1986) |
| "In 15 patients with congenital adrenal hyperplasia, the corticotrophic and melanotrophic functions were evaluated by plasma ACTH and beta-MSH radioimmunoassay." | 1.26 | Corticotrophic and melanotrophic functions in congenital adrenal hyperplasia. ( Lombardi, G; Lupoli, G; Minozzi, M; Oliver, Ch, 1977) |
| "The hypertension was alleviated by the administeration of dexamethasone in 2 of 3 patients with 17 alpha-hydroxylase deficiency." | 1.26 | Hypertension induced by adrenocortical dysfunction--hypertension in 17 alpha-hydroxylase deficiency and metopirone-induced hypertension. ( Kato, E; Kitajima, W; Kondo, K; Konishi, K; Matsuki, S; Nakamura, R; Ohguro, T; Oka, M; Ozawa, Y; Saito, I; Saruta, T; Yamagami, K, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 37 (88.10) | 18.7374 |
| 1990's | 3 (7.14) | 18.2507 |
| 2000's | 2 (4.76) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| CLEVELAND, WW | 1 |
| NIKEZIC, M | 1 |
| MIGEON, CJ | 1 |
| Halioui-Louhaichi, S | 1 |
| Azzabi, O | 1 |
| Nefzi, L | 1 |
| Ben Hariz, M | 1 |
| Ben Mrad, N | 1 |
| Ben Ammar, B | 1 |
| Maherzi, A | 1 |
| Antonipillai, I | 1 |
| Moghissi, E | 1 |
| Frasier, SD | 1 |
| Horton, R | 1 |
| Horrocks, PM | 1 |
| Kandeel, FR | 1 |
| London, DR | 1 |
| Butt, WR | 1 |
| Lynch, SS | 1 |
| Holder, G | 1 |
| Logan-Edwards, R | 1 |
| Kolanowski, J | 1 |
| Crabbe, J | 1 |
| Auzéby, A | 1 |
| Bogdan, A | 1 |
| Touitou, Y | 1 |
| Puig, J | 1 |
| Wägner, A | 1 |
| Caballero, A | 1 |
| Rodríguez-Espinosa, J | 1 |
| Webb, SM | 1 |
| Kao, PC | 1 |
| Machacek, DA | 1 |
| Magera, MJ | 1 |
| Lacey, JM | 1 |
| Rinaldo, P | 1 |
| Lombardi, G | 1 |
| Oliver, Ch | 1 |
| Lupoli, G | 1 |
| Minozzi, M | 1 |
| Saruta, T | 1 |
| Nakamura, R | 1 |
| Saito, I | 1 |
| Kondo, K | 1 |
| Ohguro, T | 1 |
| Yamagami, K | 1 |
| Kitajima, W | 1 |
| Oka, M | 1 |
| Konishi, K | 1 |
| Ozawa, Y | 1 |
| Kato, E | 1 |
| Matsuki, S | 1 |
| Waldhäusl, W | 1 |
| Herkner, K | 1 |
| Nowotny, P | 1 |
| Bratusch-Marrain, P | 1 |
| Moreira, AC | 1 |
| Leal, AM | 1 |
| Castro, M | 1 |
| Malchoff, CD | 1 |
| Rosa, J | 1 |
| DeBold, CR | 1 |
| Kozol, RA | 1 |
| Ramsby, GR | 1 |
| Page, DL | 1 |
| Malchoff, DM | 1 |
| Orth, DN | 2 |
| Takebe, K | 1 |
| Wand, GS | 1 |
| Ney, RL | 1 |
| Larsen, JL | 1 |
| Cathey, WJ | 1 |
| Odell, WD | 1 |
| Girard, J | 1 |
| Eberle, AN | 1 |
| Baumann, JB | 1 |
| Turnell, DC | 1 |
| Cooper, JD | 1 |
| Green, B | 1 |
| Hughes, G | 1 |
| Wright, DJ | 1 |
| James, VH | 1 |
| Few, JD | 2 |
| Metcalf, MG | 1 |
| Kumamoto, Y | 1 |
| Kinoshita, K | 1 |
| Hall, K | 1 |
| Hökfelt, B | 1 |
| Fehér, T | 1 |
| Nagano, T | 1 |
| Goldman, AS | 2 |
| Winter, JS | 1 |
| Bacchus, H | 1 |
| Binoux, M | 1 |
| Girard, F | 1 |
| Pham-Huu-Trung, MT | 1 |
| Canlorbe, P | 1 |
| Mozziconacci, P | 1 |
| Sturm, A | 1 |
| Berson, SA | 1 |
| Yalow, RS | 1 |
| Miura, K | 1 |
| Abe, K | 1 |
| Nicholson, WE | 1 |
| Liddle, GW | 1 |
| Island, DP | 1 |
| Faglia, G | 1 |
| Travaglini, P | 1 |
| Neri, V | 1 |
| Farrari, C | 1 |
| Gattinoni, L | 1 |
| Acerbi, L | 1 |
| New, MI | 1 |
| Seaman, MP | 1 |
| Takahara, J | 1 |
| Hashimoto, K | 1 |
| Ofuji, T | 1 |
| Horký, K | 1 |
| Kuchel, O | 1 |
| Gregorová, I | 1 |
| Stárka, L | 1 |
| Mendilaharzu, H | 1 |
| Gregory, T | 1 |
| Gardner, LI | 1 |
| Franks, RC | 1 |
| Tietze, HU | 1 |
| Zurbrugg, R | 1 |
| Zuppinger, K | 1 |
| Joss, E | 1 |
| Käser, H | 1 |
| Whigham, WR | 1 |
| Tada, T | 1 |
4 reviews available for metyrapone and Adrenal Hyperplasia, Congenital
| Article | Year |
|---|---|
Disorders of the hypothalamic-pituitary-adrenal axis.
Topics: Adrenal Cortex Hormones; Adrenal Cortex Neoplasms; Adrenal Hyperplasia, Congenital; Adrenal Insuffic | 1985 |
Primary adrenocortical nodular dysplasia, a distinct subtype of Cushing's syndrome. Case report and review of the literature.
Topics: Adolescent; Adrenal Cortex; Adrenal Hyperplasia, Congenital; Adrenalectomy; Adrenocortical Hyperfunc | 1986 |
Adrenocorticosteroids: chemistry, synthesis and disturbances in disease.
Topics: 3-Hydroxysteroid Dehydrogenases; Adrenal Cortex Hormones; Adrenal Hyperplasia, Congenital; Aldehyde- | 1985 |
[Adrenal cortex function tests and their interpretation].
Topics: Adolescent; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Adult; Aldosterone; Androg | 1969 |
1 trial available for metyrapone and Adrenal Hyperplasia, Congenital
| Article | Year |
|---|---|
Effect of aminoglutethimide on urinary steroid excretion in patients with congenital adrenal hyperplasia due to incomplete 21-hydroxylase deficiency.
Topics: 17-alpha-Hydroxypregnenolone; 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenal Hy | 1972 |
37 other studies available for metyrapone and Adrenal Hyperplasia, Congenital
| Article | Year |
|---|---|
Response to an 11beta-hydroxylase inhibitor (SU-4885) in males with adrenal hyperplasia and in their parents.
Topics: Adrenal Glands; Adrenal Hyperplasia, Congenital; Enzyme Inhibitors; Humans; Hyperplasia; Male; Metyr | 1962 |
[Treatment with metyrapone of Cushing's syndrome revealing McCune-Albright syndrome].
Topics: Adrenal Hyperplasia, Congenital; Cushing Syndrome; Enzyme Inhibitors; Female; Fibrous Dysplasia, Pol | 2005 |
The origin of plasma deoxycorticosterone in the syndrome of congenital adrenal hyperplasia and in acute states of adrenocorticotropin excess.
Topics: Adolescent; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Adult; Child; Cortodoxone; | 1983 |
Acth function in women with the polycystic ovarian syndrome.
Topics: Adolescent; Adrenal Glands; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Adult; And | 1983 |
Defective 11 beta hydroxylation in patients with congenital adrenal hyperplasia due to 21 hydroxylase deficiency.
Topics: Adrenal Hyperplasia, Congenital; Humans; Hydroxylation; Metyrapone; Steroid 11-beta-Hydroxylase; Ste | 1981 |
An alternate pathway to androstenedione synthesis by human adrenals: evidence of a balance in 11 beta-hydroxylase and 17,20-lyase activities leading to androstenedione.
Topics: Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenal Glands; Adrenal Hyperplasia, Congenital; Adult | 1995 |
Cost-effectiveness and accuracy of the tests used in the differential diagnosis of Cushing's syndrome.
Topics: ACTH Syndrome, Ectopic; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adrenocorticotropi | 1999 |
Diagnosis of adrenal cortical dysfunction by liquid chromatography-tandem mass spectrometry.
Topics: 17-alpha-Hydroxyprogesterone; Addison Disease; Adrenal Cortex Diseases; Adrenal Hyperplasia, Congeni | 2001 |
Corticotrophic and melanotrophic functions in congenital adrenal hyperplasia.
Topics: Adolescent; Adrenal Hyperplasia, Congenital; Adrenocortical Hyperfunction; Adrenocorticotropic Hormo | 1977 |
Hypertension induced by adrenocortical dysfunction--hypertension in 17 alpha-hydroxylase deficiency and metopirone-induced hypertension.
Topics: Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Adult; Animals; Cushing Syndrome; Deso | 1978 |
Combined 17 alpha- and 18-hydroxylase deficiency associated with complete male pseudohermaphroditism and hypoaldosteronism.
Topics: Adrenal Hyperplasia, Congenital; Aldosterone; Corticosterone; Desoxycorticosterone; Disorders of Sex | 1978 |
Characterization of adrenocorticotropin secretion in a patient with 17 alpha-hydroxylase deficiency.
Topics: Adolescent; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Circadian Rhythm; Corticot | 1990 |
Adrenocorticotropin-independent bilateral macronodular adrenal hyperplasia: an unusual cause of Cushing's syndrome.
Topics: Adrenal Glands; Adrenal Hyperplasia, Congenital; Adrenalectomy; Adrenocorticotropic Hormone; Cushing | 1989 |
[Clinical significance of urinary 17-hydroxycorticoid and its component analysis in endocrine tests of the adrenal cortex].
Topics: 17-Hydroxycorticosteroids; Addison Disease; Adolescent; Adrenal Cortex Function Tests; Adrenal Hyper | 1989 |
Plasma ACTH in diagnosis and control of adrenal disorders.
Topics: 17-alpha-Hydroxyprogesterone; Adenoma; Adrenal Gland Diseases; Adrenal Hyperplasia, Congenital; Adre | 1986 |
Totally automated liquid-chromatographic assay for cortisol and associated glucocorticoids in serum, with use of ASTED sample preparation.
Topics: Adrenal Hyperplasia, Congenital; Autoanalysis; Chromatography, High Pressure Liquid; Cushing Syndrom | 1988 |
Measurement of acetaldehydrogenic steroids in urine.
Topics: Acetaldehyde; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Chemistry Techniques, An | 1965 |
[Adrenogenital syndrome].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Hyperplasia, Congenital; Adrenocorti | 1965 |
Clinical and steroid metabolic studies in four siblings with congenital virilizing adrenal hyperplasia.
Topics: 17-Ketosteroids; Adolescent; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Adult; Al | 1966 |
Epiandrosterone excretion in man.
Topics: 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Cushing Syndrome; Fem | 1967 |
[Urinary excretion of pregnanetriol in various internal diseases].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Hyperplasia, Congenital; Adrenalecto | 1966 |
Activities of various steroidogenic enzymes in two forms of experimental adrenal hyperplasia.
Topics: Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Animals; Corticosterone; Female; Fluor | 1967 |
Sequential solvent extraction of urinary corticosteroids and its clinical application.
Topics: 17-Hydroxycorticosteroids; Adrenal Hyperplasia, Congenital; Adrenal Insufficiency; Adrenocorticotrop | 1967 |
[Hypophyseal-adrenal regulation in congenital adrenal hyperplasia (study of plasma corticotropic activity in 24 patients)].
Topics: Adolescent; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Child; Child, Preschool; C | 1967 |
[Progress in the clinical pathology of the adrenal cortex].
Topics: Adolescent; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Adult; Child; Cushing Synd | 1967 |
Radioimmunoassay of ACTH in plasma.
Topics: 17-Hydroxycorticosteroids; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Con | 1968 |
A simple method for the separate estimation of 11-deoxy and 11-oxygenated 17-hydroxycortico-steroids in human urine.
Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adr | 1968 |
Normal and abnormal regulation of beta-msh in man.
Topics: Addison Disease; Adolescent; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenal Hyperplasia, C | 1969 |
Occurrence of a virilizing syndrome with 21-hydroxylase deficiency after pregnancy.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hor | 1969 |
Secretion rates of cortisol and aldosterone precursors in various forms of congenital adrenal hyperplasia.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hor | 1970 |
[Gas liquid chromatography analysis of urinary neutral steroid fractions in normal persons and patients with various diseases].
Topics: 17-Ketosteroids; Adrenal Gland Diseases; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormon | 1970 |
Iatrogenic Cushing's disease in a boy after misdiagnosis of salt-losing virilizing adrenal hyperplasia: impaired metyrapone response with failure of catch-up growth.
Topics: 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adrenal Insufficiency; Adrenocorticotropic Hormone | 1973 |
Experimental model of congenital adrenal cortical hyperplasia produced in utero with an inhibitor of 11-beta-steroid hydroxylase.
Topics: Adrenal Glands; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Animals; Corticosteron | 1967 |
Screening tests for congenital adrenal hyperplasia.
Topics: 17-alpha-Hydroxypregnenolone; Adrenal Hyperplasia, Congenital; Adrenocortical Hyperfunction; Binding | 1972 |
[Cortisol regulation in childhood hypoglycemia with adrenal medulla dysfunction].
Topics: 17-Hydroxycorticosteroids; Adrenal Gland Diseases; Adrenal Hyperplasia, Congenital; Adrenal Medulla; | 1970 |
Fractionation of 17-ketogenic steroids by solvent partition.
Topics: 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Chemistry Techniques, Analytical; Humans; Methods; | 1968 |
[Clinical studies on urinary 17-ketogenic steroid fractions. 3. SU-4885 test in normal subjects and the patients with various endocrine disorders].
Topics: 17-Hydroxycorticosteroids; Acromegaly; Adenoma; Adolescent; Adrenal Cortex Hormones; Adrenal Gland N | 1968 |