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metyrapone and Adrenal Hyperplasia, Congenital

metyrapone has been researched along with Adrenal Hyperplasia, Congenital in 42 studies

Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.

Adrenal Hyperplasia, Congenital: A group of inherited disorders of the ADRENAL GLANDS, caused by enzyme defects in the synthesis of cortisol (HYDROCORTISONE) and/or ALDOSTERONE leading to accumulation of precursors for ANDROGENS. Depending on the hormone imbalance, congenital adrenal hyperplasia can be classified as salt-wasting, hypertensive, virilizing, or feminizing. Defects in STEROID 21-HYDROXYLASE; STEROID 11-BETA-HYDROXYLASE; STEROID 17-ALPHA-HYDROXYLASE; 3-beta-hydroxysteroid dehydrogenase (3-HYDROXYSTEROID DEHYDROGENASES); TESTOSTERONE 5-ALPHA-REDUCTASE; or steroidogenic acute regulatory protein; among others, underlie these disorders.

Research Excerpts

ExcerptRelevanceReference
"We present a case of McCune-Albright syndrome revealed by a Cushing's syndrome treated by metyrapone."7.73[Treatment with metyrapone of Cushing's syndrome revealing McCune-Albright syndrome]. ( Azzabi, O; Ben Ammar, B; Ben Hariz, M; Ben Mrad, N; Halioui-Louhaichi, S; Maherzi, A; Nefzi, L, 2005)
"We present a case of McCune-Albright syndrome revealed by a Cushing's syndrome treated by metyrapone."3.73[Treatment with metyrapone of Cushing's syndrome revealing McCune-Albright syndrome]. ( Azzabi, O; Ben Ammar, B; Ben Hariz, M; Ben Mrad, N; Halioui-Louhaichi, S; Maherzi, A; Nefzi, L, 2005)
" by metyrapone test or by congenital adrenal hyperplasia resulting from 11 beta-hydroxylase deficiency."3.69An alternate pathway to androstenedione synthesis by human adrenals: evidence of a balance in 11 beta-hydroxylase and 17,20-lyase activities leading to androstenedione. ( Auzéby, A; Bogdan, A; Touitou, Y, 1995)
" In congenital adrenal hyperplasia, plasma ACTH concentrations mirror, together with 17-alpha-hydroxyprogesterone, the extent of ACTH suppression."3.67Plasma ACTH in diagnosis and control of adrenal disorders. ( Baumann, JB; Eberle, AN; Girard, J, 1986)
"Serum androgen levels, including dehydroepiandrosterone sulphate (DHAS) which is thought to be solely of adrenal origin, are elevated in women with the polycystic ovarian syndrome."3.66Acth function in women with the polycystic ovarian syndrome. ( Butt, WR; Holder, G; Horrocks, PM; Kandeel, FR; Logan-Edwards, R; London, DR; Lynch, SS, 1983)
"Non-iatrogenic Cushing's syndrome has been associated primarily with three entities: pituitary-dependent processes due to pituitary adenomas or microadenomas causing adrenal hyperplasia; pituitary-independent primary adrenal causes, predominantly unilateral adenomas, rarely multiple adenomas or adrenal carcinoma; ectopic sources of adrenocorticotropic hormone (ACTH) production."2.37Primary adrenocortical nodular dysplasia, a distinct subtype of Cushing's syndrome. Case report and review of the literature. ( Cathey, WJ; Larsen, JL; Odell, WD, 1986)
"In 15 patients with congenital adrenal hyperplasia, the corticotrophic and melanotrophic functions were evaluated by plasma ACTH and beta-MSH radioimmunoassay."1.26Corticotrophic and melanotrophic functions in congenital adrenal hyperplasia. ( Lombardi, G; Lupoli, G; Minozzi, M; Oliver, Ch, 1977)
"The hypertension was alleviated by the administeration of dexamethasone in 2 of 3 patients with 17 alpha-hydroxylase deficiency."1.26Hypertension induced by adrenocortical dysfunction--hypertension in 17 alpha-hydroxylase deficiency and metopirone-induced hypertension. ( Kato, E; Kitajima, W; Kondo, K; Konishi, K; Matsuki, S; Nakamura, R; Ohguro, T; Oka, M; Ozawa, Y; Saito, I; Saruta, T; Yamagami, K, 1978)

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-199037 (88.10)18.7374
1990's3 (7.14)18.2507
2000's2 (4.76)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
CLEVELAND, WW1
NIKEZIC, M1
MIGEON, CJ1
Halioui-Louhaichi, S1
Azzabi, O1
Nefzi, L1
Ben Hariz, M1
Ben Mrad, N1
Ben Ammar, B1
Maherzi, A1
Antonipillai, I1
Moghissi, E1
Frasier, SD1
Horton, R1
Horrocks, PM1
Kandeel, FR1
London, DR1
Butt, WR1
Lynch, SS1
Holder, G1
Logan-Edwards, R1
Kolanowski, J1
Crabbe, J1
Auzéby, A1
Bogdan, A1
Touitou, Y1
Puig, J1
Wägner, A1
Caballero, A1
Rodríguez-Espinosa, J1
Webb, SM1
Kao, PC1
Machacek, DA1
Magera, MJ1
Lacey, JM1
Rinaldo, P1
Lombardi, G1
Oliver, Ch1
Lupoli, G1
Minozzi, M1
Saruta, T1
Nakamura, R1
Saito, I1
Kondo, K1
Ohguro, T1
Yamagami, K1
Kitajima, W1
Oka, M1
Konishi, K1
Ozawa, Y1
Kato, E1
Matsuki, S1
Waldhäusl, W1
Herkner, K1
Nowotny, P1
Bratusch-Marrain, P1
Moreira, AC1
Leal, AM1
Castro, M1
Malchoff, CD1
Rosa, J1
DeBold, CR1
Kozol, RA1
Ramsby, GR1
Page, DL1
Malchoff, DM1
Orth, DN2
Takebe, K1
Wand, GS1
Ney, RL1
Larsen, JL1
Cathey, WJ1
Odell, WD1
Girard, J1
Eberle, AN1
Baumann, JB1
Turnell, DC1
Cooper, JD1
Green, B1
Hughes, G1
Wright, DJ1
James, VH1
Few, JD2
Metcalf, MG1
Kumamoto, Y1
Kinoshita, K1
Hall, K1
Hökfelt, B1
Fehér, T1
Nagano, T1
Goldman, AS2
Winter, JS1
Bacchus, H1
Binoux, M1
Girard, F1
Pham-Huu-Trung, MT1
Canlorbe, P1
Mozziconacci, P1
Sturm, A1
Berson, SA1
Yalow, RS1
Miura, K1
Abe, K1
Nicholson, WE1
Liddle, GW1
Island, DP1
Faglia, G1
Travaglini, P1
Neri, V1
Farrari, C1
Gattinoni, L1
Acerbi, L1
New, MI1
Seaman, MP1
Takahara, J1
Hashimoto, K1
Ofuji, T1
Horký, K1
Kuchel, O1
Gregorová, I1
Stárka, L1
Mendilaharzu, H1
Gregory, T1
Gardner, LI1
Franks, RC1
Tietze, HU1
Zurbrugg, R1
Zuppinger, K1
Joss, E1
Käser, H1
Whigham, WR1
Tada, T1

Reviews

4 reviews available for metyrapone and Adrenal Hyperplasia, Congenital

ArticleYear
Disorders of the hypothalamic-pituitary-adrenal axis.
    Clinics in endocrinology and metabolism, 1985, Volume: 14, Issue:1

    Topics: Adrenal Cortex Hormones; Adrenal Cortex Neoplasms; Adrenal Hyperplasia, Congenital; Adrenal Insuffic

1985
Primary adrenocortical nodular dysplasia, a distinct subtype of Cushing's syndrome. Case report and review of the literature.
    The American journal of medicine, 1986, Volume: 80, Issue:5

    Topics: Adolescent; Adrenal Cortex; Adrenal Hyperplasia, Congenital; Adrenalectomy; Adrenocortical Hyperfunc

1986
Adrenocorticosteroids: chemistry, synthesis and disturbances in disease.
    Clinics in endocrinology and metabolism, 1985, Volume: 14, Issue:4

    Topics: 3-Hydroxysteroid Dehydrogenases; Adrenal Cortex Hormones; Adrenal Hyperplasia, Congenital; Aldehyde-

1985
[Adrenal cortex function tests and their interpretation].
    Nihon rinsho. Japanese journal of clinical medicine, 1969, Volume: 27, Issue:2

    Topics: Adolescent; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Adult; Aldosterone; Androg

1969

Trials

1 trial available for metyrapone and Adrenal Hyperplasia, Congenital

ArticleYear
Effect of aminoglutethimide on urinary steroid excretion in patients with congenital adrenal hyperplasia due to incomplete 21-hydroxylase deficiency.
    Metabolism: clinical and experimental, 1972, Volume: 21, Issue:4

    Topics: 17-alpha-Hydroxypregnenolone; 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenal Hy

1972

Other Studies

37 other studies available for metyrapone and Adrenal Hyperplasia, Congenital

ArticleYear
Response to an 11beta-hydroxylase inhibitor (SU-4885) in males with adrenal hyperplasia and in their parents.
    The Journal of clinical endocrinology and metabolism, 1962, Volume: 22

    Topics: Adrenal Glands; Adrenal Hyperplasia, Congenital; Enzyme Inhibitors; Humans; Hyperplasia; Male; Metyr

1962
[Treatment with metyrapone of Cushing's syndrome revealing McCune-Albright syndrome].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2005, Volume: 12, Issue:7

    Topics: Adrenal Hyperplasia, Congenital; Cushing Syndrome; Enzyme Inhibitors; Female; Fibrous Dysplasia, Pol

2005
The origin of plasma deoxycorticosterone in the syndrome of congenital adrenal hyperplasia and in acute states of adrenocorticotropin excess.
    The Journal of clinical endocrinology and metabolism, 1983, Volume: 57, Issue:3

    Topics: Adolescent; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Adult; Child; Cortodoxone;

1983
Acth function in women with the polycystic ovarian syndrome.
    Clinical endocrinology, 1983, Volume: 19, Issue:2

    Topics: Adolescent; Adrenal Glands; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Adult; And

1983
Defective 11 beta hydroxylation in patients with congenital adrenal hyperplasia due to 21 hydroxylase deficiency.
    Annales d'endocrinologie, 1981, Volume: 42, Issue:6

    Topics: Adrenal Hyperplasia, Congenital; Humans; Hydroxylation; Metyrapone; Steroid 11-beta-Hydroxylase; Ste

1981
An alternate pathway to androstenedione synthesis by human adrenals: evidence of a balance in 11 beta-hydroxylase and 17,20-lyase activities leading to androstenedione.
    The Journal of clinical endocrinology and metabolism, 1995, Volume: 80, Issue:5

    Topics: Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenal Glands; Adrenal Hyperplasia, Congenital; Adult

1995
Cost-effectiveness and accuracy of the tests used in the differential diagnosis of Cushing's syndrome.
    Pituitary, 1999, Volume: 1, Issue:2

    Topics: ACTH Syndrome, Ectopic; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adrenocorticotropi

1999
Diagnosis of adrenal cortical dysfunction by liquid chromatography-tandem mass spectrometry.
    Annals of clinical and laboratory science, 2001, Volume: 31, Issue:2

    Topics: 17-alpha-Hydroxyprogesterone; Addison Disease; Adrenal Cortex Diseases; Adrenal Hyperplasia, Congeni

2001
Corticotrophic and melanotrophic functions in congenital adrenal hyperplasia.
    Acta endocrinologica, 1977, Volume: 85, Issue:1

    Topics: Adolescent; Adrenal Hyperplasia, Congenital; Adrenocortical Hyperfunction; Adrenocorticotropic Hormo

1977
Hypertension induced by adrenocortical dysfunction--hypertension in 17 alpha-hydroxylase deficiency and metopirone-induced hypertension.
    Japanese circulation journal, 1978, Volume: 42, Issue:5

    Topics: Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Adult; Animals; Cushing Syndrome; Deso

1978
Combined 17 alpha- and 18-hydroxylase deficiency associated with complete male pseudohermaphroditism and hypoaldosteronism.
    The Journal of clinical endocrinology and metabolism, 1978, Volume: 46, Issue:2

    Topics: Adrenal Hyperplasia, Congenital; Aldosterone; Corticosterone; Desoxycorticosterone; Disorders of Sex

1978
Characterization of adrenocorticotropin secretion in a patient with 17 alpha-hydroxylase deficiency.
    The Journal of clinical endocrinology and metabolism, 1990, Volume: 71, Issue:1

    Topics: Adolescent; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Circadian Rhythm; Corticot

1990
Adrenocorticotropin-independent bilateral macronodular adrenal hyperplasia: an unusual cause of Cushing's syndrome.
    The Journal of clinical endocrinology and metabolism, 1989, Volume: 68, Issue:4

    Topics: Adrenal Glands; Adrenal Hyperplasia, Congenital; Adrenalectomy; Adrenocorticotropic Hormone; Cushing

1989
[Clinical significance of urinary 17-hydroxycorticoid and its component analysis in endocrine tests of the adrenal cortex].
    Nihon rinsho. Japanese journal of clinical medicine, 1989, Volume: 48 Suppl

    Topics: 17-Hydroxycorticosteroids; Addison Disease; Adolescent; Adrenal Cortex Function Tests; Adrenal Hyper

1989
Plasma ACTH in diagnosis and control of adrenal disorders.
    Acta endocrinologica. Supplementum, 1986, Volume: 279

    Topics: 17-alpha-Hydroxyprogesterone; Adenoma; Adrenal Gland Diseases; Adrenal Hyperplasia, Congenital; Adre

1986
Totally automated liquid-chromatographic assay for cortisol and associated glucocorticoids in serum, with use of ASTED sample preparation.
    Clinical chemistry, 1988, Volume: 34, Issue:9

    Topics: Adrenal Hyperplasia, Congenital; Autoanalysis; Chromatography, High Pressure Liquid; Cushing Syndrom

1988
Measurement of acetaldehydrogenic steroids in urine.
    Analytical biochemistry, 1965, Volume: 13, Issue:3

    Topics: Acetaldehyde; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Chemistry Techniques, An

1965
[Adrenogenital syndrome].
    Nihon Naibunpi Gakkai zasshi, 1965, Oct-20, Volume: 41, Issue:7

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Hyperplasia, Congenital; Adrenocorti

1965
Clinical and steroid metabolic studies in four siblings with congenital virilizing adrenal hyperplasia.
    Acta endocrinologica, 1966, Volume: 52, Issue:4

    Topics: 17-Ketosteroids; Adolescent; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Adult; Al

1966
Epiandrosterone excretion in man.
    The Journal of endocrinology, 1967, Volume: 38, Issue:3

    Topics: 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Cushing Syndrome; Fem

1967
[Urinary excretion of pregnanetriol in various internal diseases].
    Nihon Naibunpi Gakkai zasshi, 1966, Dec-20, Volume: 42, Issue:9

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Hyperplasia, Congenital; Adrenalecto

1966
Activities of various steroidogenic enzymes in two forms of experimental adrenal hyperplasia.
    The Journal of clinical endocrinology and metabolism, 1967, Volume: 27, Issue:12

    Topics: Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Animals; Corticosterone; Female; Fluor

1967
Sequential solvent extraction of urinary corticosteroids and its clinical application.
    Clinical chemistry, 1967, Volume: 13, Issue:10

    Topics: 17-Hydroxycorticosteroids; Adrenal Hyperplasia, Congenital; Adrenal Insufficiency; Adrenocorticotrop

1967
[Hypophyseal-adrenal regulation in congenital adrenal hyperplasia (study of plasma corticotropic activity in 24 patients)].
    Archives francaises de pediatrie, 1967, Volume: 24, Issue:4

    Topics: Adolescent; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Child; Child, Preschool; C

1967
[Progress in the clinical pathology of the adrenal cortex].
    Zentralblatt fur Chirurgie, 1967, Volume: 92, Issue:26a Pt 1

    Topics: Adolescent; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Adult; Child; Cushing Synd

1967
Radioimmunoassay of ACTH in plasma.
    The Journal of clinical investigation, 1968, Volume: 47, Issue:12

    Topics: 17-Hydroxycorticosteroids; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Con

1968
A simple method for the separate estimation of 11-deoxy and 11-oxygenated 17-hydroxycortico-steroids in human urine.
    The Journal of endocrinology, 1968, Volume: 41, Issue:2

    Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adr

1968
Normal and abnormal regulation of beta-msh in man.
    The Journal of clinical investigation, 1969, Volume: 48, Issue:8

    Topics: Addison Disease; Adolescent; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenal Hyperplasia, C

1969
Occurrence of a virilizing syndrome with 21-hydroxylase deficiency after pregnancy.
    The Journal of clinical endocrinology and metabolism, 1969, Volume: 29, Issue:10

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hor

1969
Secretion rates of cortisol and aldosterone precursors in various forms of congenital adrenal hyperplasia.
    The Journal of clinical endocrinology and metabolism, 1970, Volume: 30, Issue:3

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hor

1970
[Gas liquid chromatography analysis of urinary neutral steroid fractions in normal persons and patients with various diseases].
    Nihon Naibunpi Gakkai zasshi, 1970, Jun-20, Volume: 46, Issue:3

    Topics: 17-Ketosteroids; Adrenal Gland Diseases; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormon

1970
Iatrogenic Cushing's disease in a boy after misdiagnosis of salt-losing virilizing adrenal hyperplasia: impaired metyrapone response with failure of catch-up growth.
    The Journal of pediatrics, 1973, Volume: 83, Issue:1

    Topics: 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adrenal Insufficiency; Adrenocorticotropic Hormone

1973
Experimental model of congenital adrenal cortical hyperplasia produced in utero with an inhibitor of 11-beta-steroid hydroxylase.
    The Journal of clinical endocrinology and metabolism, 1967, Volume: 27, Issue:10

    Topics: Adrenal Glands; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Animals; Corticosteron

1967
Screening tests for congenital adrenal hyperplasia.
    The Journal of clinical endocrinology and metabolism, 1972, Volume: 35, Issue:6

    Topics: 17-alpha-Hydroxypregnenolone; Adrenal Hyperplasia, Congenital; Adrenocortical Hyperfunction; Binding

1972
[Cortisol regulation in childhood hypoglycemia with adrenal medulla dysfunction].
    Schweizerische medizinische Wochenschrift, 1970, Mar-21, Volume: 100, Issue:12

    Topics: 17-Hydroxycorticosteroids; Adrenal Gland Diseases; Adrenal Hyperplasia, Congenital; Adrenal Medulla;

1970
Fractionation of 17-ketogenic steroids by solvent partition.
    Clinical chemistry, 1968, Volume: 14, Issue:7

    Topics: 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Chemistry Techniques, Analytical; Humans; Methods;

1968
[Clinical studies on urinary 17-ketogenic steroid fractions. 3. SU-4885 test in normal subjects and the patients with various endocrine disorders].
    Nihon Naibunpi Gakkai zasshi, 1968, Mar-20, Volume: 43, Issue:12

    Topics: 17-Hydroxycorticosteroids; Acromegaly; Adenoma; Adolescent; Adrenal Cortex Hormones; Adrenal Gland N

1968