metyrapone has been researched along with Adrenal Gland Hypofunction in 106 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To discover the value of low-dose (LDAT) and standard-dose ACTH tests (SDAT) as compared with the metyrapone test in the diagnosis of secondary adrenal insufficiency." | 9.10 | Significance of low-dose and standard-dose ACTH tests compared to overnight metyrapone test in the diagnosis of adrenal insufficiency in childhood. ( Gonc, EN; Kandemir, N; Kinik, ST, 2003) |
| "The glucagon stimulation test (GST) is used for the simultaneous assessment of central adrenal insufficiency (CAI) and growth hormone deficiency." | 8.12 | Performance of glucagon stimulation test in diagnosing central adrenal insufficiency in children when utilising the Roche Elecsys ( Lombard, CJ; Zemlin, AE; Zöllner, EW, 2022) |
| "To determine whether a single measurement of ACTH instead of less available in daily practice 11-deoxycortisol assay is sufficient to rule out or confirm secondary adrenal insufficiency (SAI) in the short Metyrapone test." | 8.12 | Evaluation of plasma ACTH in the metyrapone test is insufficient for the diagnosis of secondary adrenal insufficiency. ( Glinicki, P; Leszczyńska, D; Migda, B; Nowak, K; Papierska, L; Rabijewski, M; Zgliczyński, W; Łebek-Szatańska, A, 2022) |
| " A partial adrenal insufficiency was found during Synacthen stimulation, confirmed by a slight increase of 11-desoxycortisol after metyrapone, despite a sufficient rise in ACTH levels." | 7.67 | Mechanism of adrenal suppression by high-dose medroxyprogesterone acetate in breast cancer patients. ( Doorenbos, H; Sleijfer, DT; Sluiter, WJ; van der Ploeg, E; van Veelen, H; Willemse, PH, 1985) |
| "Basal plasma adrenocorticotrophic hormone (ACTH) and cortisol concentrations as well as plasma ACTH and 11-deoxycortisol responses to the administration of a single dose of metyrapone were evaluated in 104 patients with intact pituitary-adrenal axis, in 20 patients with secondary adrenal insufficiency, and in seven patients with primary adrenal insufficiency." | 7.66 | Metyrapone test with adrenocorticotrophic levels. Separating primary from secondary adrenal insufficiency. ( Dolman, LI; Jubiz, W; Nolan, G, 1979) |
| "Metyrapone (30 mg/kg) was administered orally at 23:00 h and blood was sampled at 08:30 h the following morning for 11-deoxycortisol." | 6.71 | Investigation of the hypothalamo-pituitary-adrenal axis (HPA) by 1 microg ACTH test and metyrapone test in patients with primary fibromyalgia syndrome. ( Ates, F; Calis, M; Demir, H; Durak, AC; Gökçe, C; Izgi, HB; Kelestimur, F; Kirnap, M; Sofuoglu, S; Tutus, A; Ulker, S, 2004) |
| "To discover the value of low-dose (LDAT) and standard-dose ACTH tests (SDAT) as compared with the metyrapone test in the diagnosis of secondary adrenal insufficiency." | 5.10 | Significance of low-dose and standard-dose ACTH tests compared to overnight metyrapone test in the diagnosis of adrenal insufficiency in childhood. ( Gonc, EN; Kandemir, N; Kinik, ST, 2003) |
| "The glucagon stimulation test (GST) is used for the simultaneous assessment of central adrenal insufficiency (CAI) and growth hormone deficiency." | 4.12 | Performance of glucagon stimulation test in diagnosing central adrenal insufficiency in children when utilising the Roche Elecsys ( Lombard, CJ; Zemlin, AE; Zöllner, EW, 2022) |
| "To determine whether a single measurement of ACTH instead of less available in daily practice 11-deoxycortisol assay is sufficient to rule out or confirm secondary adrenal insufficiency (SAI) in the short Metyrapone test." | 4.12 | Evaluation of plasma ACTH in the metyrapone test is insufficient for the diagnosis of secondary adrenal insufficiency. ( Glinicki, P; Leszczyńska, D; Migda, B; Nowak, K; Papierska, L; Rabijewski, M; Zgliczyński, W; Łebek-Szatańska, A, 2022) |
| "The short Synacthen test, the overnight metyrapone test and the insulin tolerance test are frequently used in the evaluation of patients suspected of adrenal insufficiency." | 3.73 | Establishment of reference values for endocrine tests. Part IV: Adrenal insufficiency. ( Endert, E; Fliers, E; Ouwehand, A; Prummel, MF; Wiersinga, WM, 2005) |
| "We used the overnight metyrapone stimulation test to investigate the diagnostic value of the standard cosyntropin stimulation test, and the prevalence of sepsis-associated adrenal insufficiency." | 3.73 | Diagnosis of adrenal insufficiency in severe sepsis and septic shock. ( Abe, E; Alvarez, JC; Annane, D; Boudou, P; Ibrahim, F; Maxime, V, 2006) |
| "Fetal and neonatal hypoadrenalism was induced by treating rat mothers with metyrapone from day 12 of pregnancy to day 7 postnatally." | 3.68 | Perinatal hypoadrenalism in the rat does not alter glucose tolerance and insulin secretory response to glucose. ( Eriksson, UJ; Karlsson, MG; Swenne, I, 1990) |
| " In congenital adrenal hyperplasia, plasma ACTH concentrations mirror, together with 17-alpha-hydroxyprogesterone, the extent of ACTH suppression." | 3.67 | Plasma ACTH in diagnosis and control of adrenal disorders. ( Baumann, JB; Eberle, AN; Girard, J, 1986) |
| " A partial adrenal insufficiency was found during Synacthen stimulation, confirmed by a slight increase of 11-desoxycortisol after metyrapone, despite a sufficient rise in ACTH levels." | 3.67 | Mechanism of adrenal suppression by high-dose medroxyprogesterone acetate in breast cancer patients. ( Doorenbos, H; Sleijfer, DT; Sluiter, WJ; van der Ploeg, E; van Veelen, H; Willemse, PH, 1985) |
| "Basal plasma adrenocorticotrophic hormone (ACTH) and cortisol concentrations as well as plasma ACTH and 11-deoxycortisol responses to the administration of a single dose of metyrapone were evaluated in 104 patients with intact pituitary-adrenal axis, in 20 patients with secondary adrenal insufficiency, and in seven patients with primary adrenal insufficiency." | 3.66 | Metyrapone test with adrenocorticotrophic levels. Separating primary from secondary adrenal insufficiency. ( Dolman, LI; Jubiz, W; Nolan, G, 1979) |
| "Metyrapone (30 mg/kg) was administered orally at 23:00 h and blood was sampled at 08:30 h the following morning for 11-deoxycortisol." | 2.71 | Investigation of the hypothalamo-pituitary-adrenal axis (HPA) by 1 microg ACTH test and metyrapone test in patients with primary fibromyalgia syndrome. ( Ates, F; Calis, M; Demir, H; Durak, AC; Gökçe, C; Izgi, HB; Kelestimur, F; Kirnap, M; Sofuoglu, S; Tutus, A; Ulker, S, 2004) |
| "ACTH-dependent Cushing's syndrome is a heterogeneous disorder requiring a multidisciplinary and individualized approach to patient management." | 2.44 | Treatment of adrenocorticotropin-dependent Cushing's syndrome: a consensus statement. ( Bertagna, X; Bertherat, J; Biller, BM; Boscaro, M; Buchfelder, M; Colao, A; Grossman, AB; Hermus, AR; Hofland, LJ; Klibanski, A; Lacroix, A; Lindsay, JR; Melmed, S; Newell-Price, J; Nieman, LK; Petersenn, S; Sonino, N; Stalla, GK; Stewart, PM; Swearingen, B; Vance, ML; Wass, JA, 2008) |
| " Whenever possible, dosage reduction or treatment withdrawal should be considered as soon as possible depending on the underlying disease being treated." | 2.42 | [How to plan glucocorticoid withdrawal: diagnostic and therapeutic strategies]. ( Vollenweider, P; Waeber, G, 2003) |
| "Central adrenal insufficiency is rare (1." | 1.56 | Central Adrenal Insufficiency Is Rare in Adults With Prader-Willi Syndrome. ( Caixàs, A; Coupaye, M; Crinò, A; De Graaff, LCG; Goldstone, AP; Grugni, G; Høybye, C; Markovic, T; Pellikaan, K; Poitou, C; Rosenberg, AGW; Van Den Berg, SAA; Van Der Lely, AJ, 2020) |
| "A long-term recurrence rate of Cushing's disease ranging from 2%-25% has been reported." | 1.39 | [Predictors of long-term remission after transsphenoidal surgery in Cushing's disease]. ( Abellán Galiana, P; Escrivá, CM; Fajardo Montañana, C; Gómez Vela, J; Lillo, VR; Riesgo Suárez, PA, 2013) |
| "Because TS may cause pituitary insufficiency in some of these patients, early postoperative assessment of pituitary function is essential for appropriate endocrine management." | 1.38 | The use of an early postoperative CRH test to assess adrenal function after transsphenoidal surgery for pituitary adenomas. ( Biermasz, NR; Kokshoorn, NE; Pereira, AM; Rambach, AH; Roelfsema, F; Romijn, JA; Smit, JW, 2012) |
| "Metyrapone test was performed if the serum cortisol was > 83 nmol/L (> 3 microg/dL)." | 1.37 | Hypothalamic-pituitary-adrenal axis suppression in asthmatic children on inhaled and nasal corticosteroids--more common than expected? ( Galal, U; Hough, S; Irusen, E; Lombard, C; Weinberg, E; Zöllner, EW, 2011) |
| "Metyrapone (30 mg/kg) was administered at 2330 h." | 1.35 | High prevalence of central adrenal insufficiency in patients with Prader-Willi syndrome. ( de Jong, FH; de Lind van Wijngaarden, RF; Festen, DA; Hokken-Koelega, AC; Joosten, KF; Otten, BJ; Sweep, FC, 2008) |
| "A 52-year-old woman experienced hypoadrenalism (mean 8 AM plasma cortisol level, 3." | 1.26 | Stress-induced cortisol release in hypothalamic hypoadrenalism. ( Glass, AR; Smith, CE, 1979) |
| "Medroxyprogesterone (MPA) is a progestin with no clinically detectable estrogenic and androgenic properties used in the treatment of sexual precocity." | 1.25 | Adverse effects of large doses of medroxyprogesterone (MPA) in idiopathic isosexual precocity. ( French, FS; Richman, RA; Underwood, LE; Van Wyk, JJ, 1971) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 74 (69.81) | 18.7374 |
| 1990's | 7 (6.60) | 18.2507 |
| 2000's | 11 (10.38) | 29.6817 |
| 2010's | 11 (10.38) | 24.3611 |
| 2020's | 3 (2.83) | 2.80 |
| Authors | Studies |
|---|---|
| Zöllner, EW | 3 |
| Lombard, CJ | 2 |
| Zemlin, AE | 1 |
| Papierska, L | 3 |
| Rabijewski, M | 3 |
| Migda, B | 3 |
| Leszczyńska, D | 3 |
| Nowak, K | 3 |
| Łebek-Szatańska, A | 3 |
| Glinicki, P | 3 |
| Zgliczyński, W | 3 |
| Rosenberg, AGW | 1 |
| Pellikaan, K | 1 |
| Poitou, C | 1 |
| Goldstone, AP | 2 |
| Høybye, C | 1 |
| Markovic, T | 1 |
| Grugni, G | 1 |
| Crinò, A | 1 |
| Caixàs, A | 1 |
| Coupaye, M | 1 |
| Van Den Berg, SAA | 1 |
| Van Der Lely, AJ | 1 |
| De Graaff, LCG | 1 |
| English, K | 1 |
| Inder, WJ | 1 |
| Weedon, Z | 1 |
| Dimeski, G | 1 |
| Sorbello, J | 1 |
| Russell, AW | 1 |
| Duncan, EL | 1 |
| Cuneo, R | 1 |
| Obrynba, KS | 1 |
| Hoffman, RP | 1 |
| Repaske, DR | 1 |
| Anglin, K | 1 |
| Kamboj, MK | 1 |
| Delivanis, DA | 1 |
| Athimulam, S | 1 |
| Bancos, I | 1 |
| de Lind van Wijngaarden, RF | 2 |
| Joosten, KF | 2 |
| van den Berg, S | 1 |
| Otten, BJ | 2 |
| de Jong, FH | 2 |
| Sweep, CG | 1 |
| de Weerd, AW | 1 |
| Hokken-Koelega, AC | 2 |
| Mangan, JK | 1 |
| Russell, JE | 1 |
| Ismail, AA | 1 |
| Kazlauskaite, R | 1 |
| Maghnie, M | 1 |
| Moraes, RB | 1 |
| Czepielewski, MA | 1 |
| Friedman, G | 1 |
| Borba, EL | 1 |
| Kokshoorn, NE | 1 |
| Romijn, JA | 1 |
| Roelfsema, F | 1 |
| Rambach, AH | 1 |
| Smit, JW | 1 |
| Biermasz, NR | 1 |
| Pereira, AM | 1 |
| Lombard, C | 1 |
| Galal, U | 2 |
| Hough, S | 1 |
| Irusen, E | 1 |
| Weinberg, E | 2 |
| Cegla, J | 1 |
| Jones, B | 1 |
| Seyani, L | 1 |
| Papadoulou, D | 1 |
| Wynne, K | 1 |
| Martin, NM | 1 |
| Meeran, K | 1 |
| Chapman, R | 1 |
| Donaldson, M | 1 |
| Tan, T | 1 |
| Hough, FS | 1 |
| Irusen, EM | 1 |
| Abellán Galiana, P | 1 |
| Fajardo Montañana, C | 1 |
| Riesgo Suárez, PA | 1 |
| Gómez Vela, J | 1 |
| Escrivá, CM | 1 |
| Lillo, VR | 1 |
| DONALD, HR | 1 |
| PARIS, J | 1 |
| LEFER, AM | 2 |
| NADZAM, GR | 1 |
| LACKOVA, E | 1 |
| LISA, L | 1 |
| JANSA, M | 1 |
| RIVADENEYRA, J | 1 |
| TOUYABOGGIANO, JJ | 1 |
| MEDOC, J | 1 |
| FRENKEL, JK | 1 |
| HINSHAW, CT | 1 |
| RUTH, W | 1 |
| BROWN, R | 1 |
| BAKKE, JL | 1 |
| SUTFIN, DC | 1 |
| SARVER, ME | 1 |
| SABEH, G | 1 |
| FETTERMAN, GH | 1 |
| WALD, N | 1 |
| DANOWSKI, TS | 1 |
| KERNOHAN, RJ | 1 |
| Davison, K | 1 |
| Roth, M | 1 |
| Gibson, A | 1 |
| LOUYOT, P | 1 |
| GAUCHER, A | 1 |
| BENOIT, P | 1 |
| NAVARRO, A | 1 |
| RAVERA, JJ | 1 |
| MUXI, F | 1 |
| DEDELFINO, Z | 1 |
| TOUYA, JJ | 1 |
| LEACH, RB | 1 |
| MARGULIS, RR | 1 |
| Gonc, EN | 1 |
| Kandemir, N | 1 |
| Kinik, ST | 1 |
| Vollenweider, P | 1 |
| Waeber, G | 1 |
| Nieman, LK | 2 |
| Calis, M | 1 |
| Gökçe, C | 1 |
| Ates, F | 1 |
| Ulker, S | 1 |
| Izgi, HB | 1 |
| Demir, H | 1 |
| Kirnap, M | 1 |
| Sofuoglu, S | 1 |
| Durak, AC | 1 |
| Tutus, A | 1 |
| Kelestimur, F | 1 |
| Endert, E | 1 |
| Ouwehand, A | 1 |
| Fliers, E | 1 |
| Prummel, MF | 1 |
| Wiersinga, WM | 1 |
| Annane, D | 1 |
| Maxime, V | 1 |
| Ibrahim, F | 1 |
| Alvarez, JC | 1 |
| Abe, E | 1 |
| Boudou, P | 1 |
| Festen, DA | 1 |
| Sweep, FC | 1 |
| Biller, BM | 1 |
| Grossman, AB | 1 |
| Stewart, PM | 1 |
| Melmed, S | 1 |
| Bertagna, X | 2 |
| Bertherat, J | 1 |
| Buchfelder, M | 1 |
| Colao, A | 1 |
| Hermus, AR | 1 |
| Hofland, LJ | 1 |
| Klibanski, A | 1 |
| Lacroix, A | 1 |
| Lindsay, JR | 1 |
| Newell-Price, J | 1 |
| Petersenn, S | 1 |
| Sonino, N | 1 |
| Stalla, GK | 1 |
| Swearingen, B | 1 |
| Vance, ML | 1 |
| Wass, JA | 1 |
| Boscaro, M | 1 |
| Carr, RD | 1 |
| Wieland, RG | 1 |
| Chaieb, L | 1 |
| Vidal-Trecan, G | 1 |
| Laudat, MH | 3 |
| Guilhaume, B | 1 |
| Bricaire, H | 2 |
| Luton, JP | 3 |
| Stacpoole, PW | 1 |
| Interlandi, JW | 1 |
| Nicholson, WE | 1 |
| Rabin, D | 1 |
| Cunningham, SK | 2 |
| Moore, A | 1 |
| McKenna, TJ | 2 |
| Kuhn, JM | 1 |
| Balacheff-Carrara, O | 1 |
| Legrand, A | 1 |
| Houdent, C | 1 |
| Wolf, LM | 1 |
| Fiad, TM | 1 |
| Kirby, JM | 1 |
| Blevins, LS | 1 |
| Dobs, AS | 1 |
| Wand, GS | 2 |
| Koshiyama, H | 1 |
| Hockings, GI | 1 |
| Strakosch, CR | 1 |
| Jackson, RV | 1 |
| Tanaka, K | 1 |
| Toriumi, M | 1 |
| Itoh, S | 1 |
| Ogino, Y | 1 |
| Eledrisi, MS | 1 |
| Verghese, AC | 1 |
| Besser, GM | 2 |
| Jeffcoate, WJ | 1 |
| Lücking, T | 1 |
| Wilig, RP | 1 |
| West, CD | 2 |
| Dolman, LI | 2 |
| Nolan, G | 1 |
| Jubiz, W | 2 |
| Glass, AR | 1 |
| Smith, CE | 1 |
| Giacovazzo, M | 1 |
| Loewenstein, JE | 1 |
| Snow, K | 1 |
| Jiang, NS | 1 |
| Kao, PC | 1 |
| Scheithauer, BW | 1 |
| Karlsson, MG | 1 |
| Eriksson, UJ | 1 |
| Swenne, I | 1 |
| Sagara, Y | 2 |
| Okatani, Y | 2 |
| Chanson, P | 1 |
| Rieu, M | 1 |
| Strauch, G | 1 |
| Hartzband, PI | 1 |
| Van Herle, AJ | 1 |
| Sorger, L | 1 |
| Cope, D | 1 |
| Huiras, CM | 1 |
| Pehling, GB | 1 |
| Caplan, RH | 1 |
| Ney, RL | 1 |
| Girard, J | 1 |
| Eberle, AN | 1 |
| Baumann, JB | 1 |
| de Peretti, E | 1 |
| Forest, MG | 1 |
| Loras, B | 1 |
| Morel, Y | 1 |
| David, M | 1 |
| François, R | 1 |
| Bertrand, J | 1 |
| Trulson, ME | 1 |
| Ulissey, MJ | 1 |
| van Veelen, H | 1 |
| Willemse, PH | 1 |
| Sleijfer, DT | 1 |
| van der Ploeg, E | 1 |
| Sluiter, WJ | 2 |
| Doorenbos, H | 2 |
| de Lange, WE | 1 |
| Pratt, JJ | 1 |
| Wolf, RF | 1 |
| Tucker, WS | 1 |
| Snell, BB | 1 |
| Island, DP | 1 |
| Gregg, CR | 1 |
| Gillin, JC | 1 |
| Jacobs, LS | 1 |
| Snyder, F | 1 |
| Henkin, RI | 1 |
| Pratt, JH | 1 |
| Sawin, CT | 1 |
| Melby, JC | 1 |
| Vivacqua, RJ | 1 |
| Haurani, FI | 1 |
| Erslev, AJ | 1 |
| Radó, JP | 1 |
| Takó, J | 1 |
| Borsch-Galetke, E | 1 |
| Dransfeld, H | 1 |
| Greeff, K | 1 |
| Góth, E | 1 |
| Görgényi, G | 1 |
| Fövényi, J | 1 |
| Szántó, E | 1 |
| Bacchus, H | 1 |
| Isidori, A | 1 |
| Frajese, G | 1 |
| Dondero, F | 1 |
| Heni, F | 1 |
| Ruedi, B | 2 |
| Felber, JP | 1 |
| Aubert, M | 1 |
| Sako, Y | 1 |
| Leprat, J | 1 |
| Kubo, N | 1 |
| Cullen, DR | 1 |
| Irvine, WJ | 1 |
| Landon, J | 1 |
| Davis, BB | 1 |
| Bloom, ME | 1 |
| Field, JB | 1 |
| Mintz, DH | 1 |
| Knol, K | 1 |
| Tobin, MS | 1 |
| Kossowsky, WA | 1 |
| Foltyn, H | 1 |
| Saitmacher, F | 1 |
| Toft, H | 1 |
| Buus, O | 1 |
| Nielsen, E | 1 |
| Duckworth, WC | 1 |
| Kitabchi, AE | 1 |
| Richman, RA | 1 |
| Underwood, LE | 1 |
| French, FS | 1 |
| Van Wyk, JJ | 1 |
| Borel, GA | 1 |
| Magnenat, P | 1 |
| Asfeldt, VH | 1 |
| Bethge, H | 2 |
| Winkelmann, W | 2 |
| Bayer, JM | 1 |
| Kracht, J | 1 |
| Hackenberg, K | 2 |
| Tăpălagă, D | 1 |
| Szántay, I | 1 |
| Szabó, P | 1 |
| Tamás, S | 1 |
| Mendilaharzu, H | 1 |
| Gregory, T | 1 |
| Gardner, LI | 1 |
| Hicks, R | 1 |
| Hendrikse, JC | 1 |
| Moolenaar, AJ | 1 |
| Laurent de Angulo, MS | 1 |
| van Gelderen, HH | 1 |
| Clary, JJ | 1 |
| Stokinger, HE | 1 |
| Conn, FW | 1 |
| Mast, TE | 1 |
| Heesen, D | 1 |
| Mies, R | 1 |
| Genova, R | 1 |
| Massolo, F | 1 |
| Galli, V | 1 |
| Meikle, AW | 1 |
| Hutchings, MP | 1 |
| Tyler, FH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Total, Salivary and Calculated Free Cortisol Levels in Patients With Severe Sepsis[NCT02589431] | 46 participants (Actual) | Observational | 2009-06-30 | Completed | |||
| Treatment of Pituitary Cushing Disease With a Selective CDK Inhibitor, R-roscovitine[NCT02160730] | Phase 2 | 4 participants (Actual) | Interventional | 2014-05-31 | Terminated (stopped due to NIH grant ended.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The number of participants that achieved a urinary free cortisol level above the upper limit of the normal range but reduced by ≥50% from baseline at week 4. (NCT02160730)
Timeframe: Baseline, Week 4
| Intervention | Participants (Count of Participants) |
|---|---|
| R-roscovitine | 2 |
A visible change in tumor size as determined by the investigator after reviewing MRI reports between baseline and 4 weeks of treatment. (NCT02160730)
Timeframe: Baseline, 4 weeks
| Intervention | Participants (Count of Participants) |
|---|---|
| R-roscovitine | 0 |
"To evaluate the efficacy of R-roscovitine 400 mg oral administration twice daily for 4 days every week for total of 4 weeks on normalizing 24 hour urinary free cortisol (24 h UFC) levels in CD patients. Normalizing is defined as having urine free cortisol levels within the normal range for that lab value." (NCT02160730)
Timeframe: Baseline, 4 weeks
| Intervention | Participants (Count of Participants) |
|---|---|
| R-roscovitine | 0 |
The number of participants that experience an adverse event between baseline and study end likely related to study drug as a measure of safety and tolerability. (NCT02160730)
Timeframe: Baseline, 4 weeks
| Intervention | Participants (Count of Participants) |
|---|---|
| R-roscovitine | 2 |
Change in typical Cushing's syndrome clinical signs and symptoms defined by mean weight at baseline and 4 weeks. (NCT02160730)
Timeframe: Baseline, 4 weeks
| Intervention | lbs (Mean) | |
|---|---|---|
| Baseline | 4 Weeks | |
| R-roscovitine | 217 | 217.4 |
Mean diastolic blood pressure between baseline and 4 weeks. (NCT02160730)
Timeframe: Baseline, 4 weeks
| Intervention | mmHg (Mean) | |
|---|---|---|
| Baseline | 4 Weeks | |
| R-roscovitine | 76.5 | 71 |
HbA1c levels are measured at baseline and at study end, these are averaged across all subjects. (NCT02160730)
Timeframe: Baseline, 4 Weeks
| Intervention | Percentage (Mean) | |
|---|---|---|
| Baseline | Study End-4 weeks | |
| R-roscovitine | 6.9 | 7 |
Mean change in systolic blood pressure between baseline and 4 weeks. (NCT02160730)
Timeframe: Baseline, 4 weeks
| Intervention | mmHg (Mean) | |
|---|---|---|
| Baseline | 4 weeks | |
| R-roscovitine | 150.3 | 128.3 |
Mean serum cortisol values at baseline and 4 weeks (NCT02160730)
Timeframe: Baseline, 4 weeks
| Intervention | mg/dL (Mean) | |
|---|---|---|
| Baseline | 4 Weeks | |
| R-roscovitine | 25.6 | 27.1 |
Mean change between baseline and week 4 of fasting blood glucose levels. (NCT02160730)
Timeframe: Baseline, 4 Weeks
| Intervention | g/dL (Mean) | |
|---|---|---|
| Baseline | 4 weeks | |
| R-roscovitine | 121.4 | 104.3 |
Mean change in Plasma ACTH between baseline and 4 weeks. (NCT02160730)
Timeframe: Baseline, 4 weeks
| Intervention | pg/mL (Mean) | |
|---|---|---|
| Baseline | 4 weeks | |
| R-roscovitine | 79.3 | 79.9 |
11 reviews available for metyrapone and Adrenal Gland Hypofunction
| Article | Year |
|---|---|
Pitfalls in the diagnosis of central adrenal insufficiency in children.
Topics: Adolescent; Adrenal Insufficiency; Adrenocorticotropic Hormone; Algorithms; Antimetabolites; Child; | 2010 |
Diagnosis of adrenal failure in critically ill patients.
Topics: Adrenal Insufficiency; Adrenocorticotropic Hormone; Arginine Vasopressin; Corticotropin-Releasing Ho | 2011 |
ON THE DIAGNOSIS OF ADDISON'S DISEASE AND CUSHING'S SYNDROME BY LABORATORY METHODS.
Topics: 17-Ketosteroids; Addison Disease; Adrenal Insufficiency; Adrenocorticotropic Hormone; Biochemical Ph | 1964 |
[How to plan glucocorticoid withdrawal: diagnostic and therapeutic strategies].
Topics: Acute Disease; Adrenal Insufficiency; Adrenocorticotropic Hormone; Aged; Antimetabolites; Circadian | 2003 |
Dynamic evaluation of adrenal hypofunction.
Topics: Adrenal Cortex Function Tests; Adrenal Insufficiency; Adrenocorticotropic Hormone; Corticotropin-Rel | 2003 |
Treatment of adrenocorticotropin-dependent Cushing's syndrome: a consensus statement.
Topics: ACTH Syndrome, Ectopic; Adrenal Insufficiency; Adrenalectomy; Adrenocorticotropic Hormone; Cushing S | 2008 |
Secondary adrenocortical insufficiency: avoiding potentially fatal pitfalls in diagnosis and treatment.
Topics: Adrenal Cortex Diseases; Adrenal Insufficiency; Cosyntropin; Glucocorticoids; Humans; Metyrapone | 1997 |
[Metyrapone test].
Topics: ACTH Syndrome, Ectopic; Adrenal Cortex Diseases; Adrenal Cortex Function Tests; Adrenal Insufficienc | 1997 |
Adrenal insufficiency in HIV infection: a review and recommendations.
Topics: Adrenal Glands; Adrenal Insufficiency; Adult; AIDS-Related Opportunistic Infections; Anti-HIV Agents | 2001 |
Disorders of the hypothalamic-pituitary-adrenal axis.
Topics: Adrenal Cortex Hormones; Adrenal Cortex Neoplasms; Adrenal Hyperplasia, Congenital; Adrenal Insuffic | 1985 |
[On the diagnosis of adrenal cortex insufficiency].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Insufficiency; Adrenocorticotropic Hormone; Adul | 1968 |
3 trials available for metyrapone and Adrenal Gland Hypofunction
| Article | Year |
|---|---|
The relationship between central adrenal insufficiency and sleep-related breathing disorders in children with Prader-Willi syndrome.
Topics: Adrenal Insufficiency; Child; Child, Preschool; Diagnostic Techniques, Endocrine; Female; Humans; Ma | 2009 |
Significance of low-dose and standard-dose ACTH tests compared to overnight metyrapone test in the diagnosis of adrenal insufficiency in childhood.
Topics: Adolescent; Adrenal Insufficiency; Adrenocorticotropic Hormone; Adult; Child; Child, Preschool; Dose | 2003 |
Investigation of the hypothalamo-pituitary-adrenal axis (HPA) by 1 microg ACTH test and metyrapone test in patients with primary fibromyalgia syndrome.
Topics: Adrenal Glands; Adrenal Insufficiency; Adrenocorticotropic Hormone; Cortodoxone; Female; Fibromyalgi | 2004 |
92 other studies available for metyrapone and Adrenal Gland Hypofunction
| Article | Year |
|---|---|
Performance of glucagon stimulation test in diagnosing central adrenal insufficiency in children when utilising the Roche Elecsys
Topics: Adolescent; Adrenal Insufficiency; Adrenocorticotropic Hormone; Child; Cortodoxone; Female; Glucagon | 2022 |
Evaluation of plasma ACTH in the metyrapone test is insufficient for the diagnosis of secondary adrenal insufficiency.
Topics: Adrenal Insufficiency; Adrenocorticotropic Hormone; Cortodoxone; Humans; Hydrocortisone; Metyrapone; | 2022 |
Evaluation of plasma ACTH in the metyrapone test is insufficient for the diagnosis of secondary adrenal insufficiency.
Topics: Adrenal Insufficiency; Adrenocorticotropic Hormone; Cortodoxone; Humans; Hydrocortisone; Metyrapone; | 2022 |
Evaluation of plasma ACTH in the metyrapone test is insufficient for the diagnosis of secondary adrenal insufficiency.
Topics: Adrenal Insufficiency; Adrenocorticotropic Hormone; Cortodoxone; Humans; Hydrocortisone; Metyrapone; | 2022 |
Evaluation of plasma ACTH in the metyrapone test is insufficient for the diagnosis of secondary adrenal insufficiency.
Topics: Adrenal Insufficiency; Adrenocorticotropic Hormone; Cortodoxone; Humans; Hydrocortisone; Metyrapone; | 2022 |
Central Adrenal Insufficiency Is Rare in Adults With Prader-Willi Syndrome.
Topics: Adolescent; Adrenal Insufficiency; Adult; Comorbidity; Female; Humans; Hypothalamo-Hypophyseal Syste | 2020 |
Prospective evaluation of a week one overnight metyrapone test with subsequent dynamic assessments of hypothalamic-pituitary-adrenal axis function after pituitary surgery.
Topics: Adrenal Insufficiency; Adult; Female; Glucocorticoids; Humans; Hydrocortisone; Hypothalamo-Hypophyse | 2017 |
No central adrenal insufficiency found in patients with Prader-Willi syndrome with an overnight metyrapone test.
Topics: Adolescent; Adrenal Insufficiency; Adult; Child; Child, Preschool; Cohort Studies; Diagnostic Tests, | 2018 |
Modern Management of Mild Autonomous Cortisol Secretion.
Topics: 14-alpha Demethylase Inhibitors; Adrenal Cortex Neoplasms; Adrenal Insufficiency; Adrenalectomy; Adr | 2019 |
Profound neutropenia resulting from metyrapone-induced adrenal crisis.
Topics: Adrenal Insufficiency; Antimetabolites; Cushing Syndrome; Female; Humans; Metyrapone; Middle Aged; N | 2009 |
On the diagnosis and investigation of adrenal insufficiency in adults.
Topics: Adrenal Insufficiency; Adult; Diagnostic Techniques, Endocrine; Glucagon; Humans; Hypothalamic Disea | 2010 |
The use of an early postoperative CRH test to assess adrenal function after transsphenoidal surgery for pituitary adenomas.
Topics: Adenoma; Adolescent; Adrenal Insufficiency; Adult; Aged; Aged, 80 and over; Corticotropin-Releasing | 2012 |
Hypothalamic-pituitary-adrenal axis suppression in asthmatic children on inhaled and nasal corticosteroids--more common than expected?
Topics: Administration, Inhalation; Administration, Intranasal; Adolescent; Adrenal Cortex Hormones; Adrenal | 2011 |
Comparison of the overnight metyrapone and glucagon stimulation tests in the assessment of secondary hypoadrenalism.
Topics: Adrenal Insufficiency; Adult; Female; Glucagon; Humans; Hypothalamo-Hypophyseal System; Male; Metyra | 2013 |
Hypothalamic-pituitary-adrenal axis suppression in asthmatic school children.
Topics: Administration, Inhalation; Adolescent; Adrenal Cortex Hormones; Adrenal Insufficiency; Adrenocortic | 2012 |
[Predictors of long-term remission after transsphenoidal surgery in Cushing's disease].
Topics: ACTH-Secreting Pituitary Adenoma; Adenoma; Adolescent; Adrenal Insufficiency; Adrenocorticotropic Ho | 2013 |
SPECIFIC HYPOADRENOTROPISM.
Topics: Adrenal Insufficiency; Adrenocorticotropic Hormone; Diagnosis; Edema; Eunuchism; Humans; Hydrocortis | 1963 |
CARDIOVASCULAR EFFECTS OF SU-4885 (MEPYRAPONE), AN INHIBITOR OF CORTICOSTEROID BIOSYNTHESIS.
Topics: Adrenal Cortex Hormones; Adrenal Insufficiency; Anti-Arrhythmia Agents; Aorta; Blood Flow Velocity; | 1964 |
[EXCRETION OF 17-HYDROXYCORTICOSTEROIDS FOLLOWING METOPIRONE].
Topics: 17-Hydroxycorticosteroids; Adrenal Cortex Hormones; Adrenal Insufficiency; Adrenocorticotropic Hormo | 1964 |
[INVESTIGATION OF THE BIOLOGICAL ACTIVITIES OF TRIAMCINOLONE DIACETATE IN PATIENTS WITH ADRENAL INSUFFICIENCY].
Topics: Adrenal Cortex Hormones; Adrenal Insufficiency; Adrenalectomy; Aldosterone; Blood; Blood Pressure; B | 1964 |
[HYPOPHYSARY COMA IN SHEEHAN'S SYNDROME. ANATOMOCLINICAL STUDY].
Topics: Adrenal Insufficiency; Coma; Desoxycorticosterone; Diagnosis, Differential; Female; Humans; Hydrocor | 1963 |
PITUITARY-ADRENAL FUNCTION IN CHRONIC PULMONARY TUBERCULOSIS.
Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Insufficiency; Adrenocorticotropic Hormone; Blood; | 1964 |
CARDIOVASCULAR EFFECTS OF CATECHOLAMINES IN EXPERIMENTAL ADRENAL INSUFFICIENCY.
Topics: Adrenal Insufficiency; Adrenalectomy; Aorta; Blood Flow Velocity; Blood Pressure; Blood Pressure Det | 1964 |
FRACTIONAL HYPOPITUITARISM WITH GIANTISM AND NORMAL SELLA TURCICA.
Topics: Adrenal Insufficiency; Adrenocorticotropic Hormone; Chromosome Aberrations; Fluids and Secretions; G | 1964 |
METYRAPONE AND ACUTE ADRENAL INSUFFICIENCY.
Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Insufficiency; Arthritis; Arthritis, Rheumatoid; F | 1964 |
PREMATURELY AGED APPEARANCE AND SIMULATED ENDOCRINE DISORDER IN CHRONIC ANXIETY.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Insufficiency; Adrenocorticotropic Hormone; Anxi | 1964 |
[THE ACTION OF PROLONGED CORTICOTHERAPY ON CORTICOTROPIC AND ADRENAL FUNCTION (STUDIED BY MEANS OF THE METOPIRONE TEST)].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Insufficiency; Adrenoco | 1964 |
[CLINICALLY CURED ADDISON'S DISEASE. STUDY WITH ACTH AND METOPIRONE].
Topics: Addison Disease; Adrenal Insufficiency; Adrenocorticotropic Hormone; Drug Therapy; Hypoadrenocortici | 1964 |
INHIBITION OF ADRENOCORTICAL RESPONSIVENESS DURING PROGESTIN THERAPY.
Topics: Adrenal Insufficiency; Adrenocorticotropic Hormone; Contraceptive Agents; Contraceptives, Oral; Ethi | 1965 |
Establishment of reference values for endocrine tests. Part IV: Adrenal insufficiency.
Topics: Adrenal Cortex Function Tests; Adrenal Insufficiency; Adrenocorticotropic Hormone; Adult; Aged; Anti | 2005 |
Diagnosis of adrenal insufficiency in severe sepsis and septic shock.
Topics: Adrenal Insufficiency; Adrenocorticotropic Hormone; Aged; Cosyntropin; Female; Humans; Hydrocortison | 2006 |
High prevalence of central adrenal insufficiency in patients with Prader-Willi syndrome.
Topics: Adolescent; Adrenal Insufficiency; Adrenocorticotropic Hormone; Blood Pressure; Child; Child, Presch | 2008 |
Adrenocortical suppression with topical flumethasone.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Insufficiency; Adult; Female; Glucocorticoids; H | 1967 |
[Rapid beta 1-24-corticotropin test in the exploration of the corticotropic axis. 71 cases].
Topics: Adolescent; Adrenal Cortex Function Tests; Adrenal Insufficiency; Adrenocorticotropic Hormone; Adult | 1984 |
Isolated ACTH deficiency: a heterogeneous disorder. Critical review and report of four new cases.
Topics: 17-Hydroxycorticosteroids; Adrenal Insufficiency; Adrenocorticotropic Hormone; Adult; Blood Glucose; | 1982 |
Normal cortisol response to corticotropin in patients with secondary adrenal failure.
Topics: Adrenal Insufficiency; Adrenocorticotropic Hormone; Cosyntropin; Glucocorticoids; Humans; Hydrocorti | 1983 |
[Study of corticotropic function: respective values of short tests using metropirone and exogenous ACTH regardless of the hour administered].
Topics: Adrenal Cortex Function Tests; Adrenal Insufficiency; Adrenocorticotropic Hormone; Adult; Humans; Me | 1983 |
The overnight single-dose metyrapone test is a simple and reliable index of the hypothalamic-pituitary-adrenal axis.
Topics: Adrenal Insufficiency; Adrenocorticotropic Hormone; Cortodoxone; Humans; Hydrocortisone; Hypoglycemi | 1994 |
Naloxone-induced activation of the hypothalamic-pituitary-adrenal axis in suspected central adrenal insufficiency.
Topics: Adrenal Glands; Adrenal Insufficiency; Adrenocorticotropic Hormone; Adult; Aged; Female; Glucocortic | 1994 |
The potential for serious consequences from misinterpretation of normal responses to the rapid adrenocorticotropin test.
Topics: Adrenal Insufficiency; Adrenocorticotropic Hormone; Humans; Hydrocortisone; Hypothalamo-Hypophyseal | 1996 |
Endocrine and metabolic diseases. Adrenal diseases.
Topics: Adenoma; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenal Insuffici | 1976 |
[Selective ACTH deficiency in two siblings (author's transl)].
Topics: Adrenal Cortex Hormones; Adrenal Insufficiency; Adrenocorticotropic Hormone; Adult; Child, Preschool | 1975 |
Plasma ACTH radioimmunoassays in the diagnosis of pituitary-adrenal dysfunction.
Topics: Adrenal Insufficiency; Adrenocorticotropic Hormone; Cushing Syndrome; Dexamethasone; Humans; Metyrap | 1977 |
Metyrapone test with adrenocorticotrophic levels. Separating primary from secondary adrenal insufficiency.
Topics: Adrenal Insufficiency; Adrenocorticotropic Hormone; Cortodoxone; Diagnosis, Differential; Humans; Hy | 1979 |
Stress-induced cortisol release in hypothalamic hypoadrenalism.
Topics: 17-Hydroxycorticosteroids; Adrenal Insufficiency; Adrenocorticotropic Hormone; Circadian Rhythm; Cra | 1979 |
[Treatment of rheumatoid arthritis].
Topics: Adrenal Glands; Adrenal Insufficiency; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antimalarial | 1975 |
Testing adrenal function--1975.
Topics: Adolescent; Adrenal Cortex Function Tests; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal | 1975 |
Biochemical evaluation of adrenal dysfunction: the laboratory perspective.
Topics: Adolescent; Adrenal Insufficiency; Adrenocorticotropic Hormone; Adult; Aged; Child; Cushing Syndrome | 1992 |
Perinatal hypoadrenalism in the rat does not alter glucose tolerance and insulin secretory response to glucose.
Topics: Adrenal Insufficiency; Animals; Animals, Newborn; Body Weight; Corticosterone; Female; Fetus; Glucos | 1990 |
[Clinical significance of urinary tetrahydro-11-deoxycortisol analysis in endocrine tests of the adrenal cortex].
Topics: 17-Hydroxycorticosteroids; Adrenal Cortex Function Tests; Adrenal Insufficiency; Adrenocortical Hype | 1989 |
[Clinical significance of serum 11-deoxycortisol analysis in endocrine tests of the adrenal cortex].
Topics: 17-Hydroxycorticosteroids; Adrenal Cortex Function Tests; Adrenal Insufficiency; Adrenocortical Hype | 1989 |
[Discordance between the short and standard metyrapone tests in isolated corticotropin insufficiency].
Topics: Adrenal Insufficiency; Adrenocorticotropic Hormone; Aged; Cortodoxone; False Negative Reactions; Hum | 1987 |
Assessment of hypothalamic-pituitary-adrenal (HPA) axis dysfunction: comparison of ACTH stimulation, insulin-hypoglycemia and metyrapone.
Topics: Adrenal Cortex Hormones; Adrenal Insufficiency; Adrenocorticotropic Hormone; Adult; Aged; Aldosteron | 1988 |
Adrenal insufficiency after operative removal of apparently nonfunctioning adrenal adenomas.
Topics: Adenoma; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenal Insufficiency; Adrenalectomy; Dex | 1989 |
Plasma ACTH in diagnosis and control of adrenal disorders.
Topics: 17-alpha-Hydroxyprogesterone; Adenoma; Adrenal Gland Diseases; Adrenal Hyperplasia, Congenital; Adre | 1986 |
Usefulness of plasma pregnenolone sulfate in testing pituitary-adrenal function in children.
Topics: Adolescent; Adrenal Gland Diseases; Adrenal Insufficiency; Adrenocorticotropic Hormone; Aging; Child | 1986 |
Low doses of L-tryptophan are lethal in rats with adrenal insufficiency.
Topics: Adrenal Insufficiency; Adrenalectomy; Animals; Corticosterone; Disease Models, Animal; Lethal Dose 5 | 1987 |
Mechanism of adrenal suppression by high-dose medroxyprogesterone acetate in breast cancer patients.
Topics: 17-alpha-Hydroxyprogesterone; Adrenal Insufficiency; Aged; Androstenedione; Breast Neoplasms; Cosynt | 1985 |
Is the ovine CRF test an aid in the evaluation of patients with secondary adrenal insufficiency?
Topics: Adolescent; Adrenal Insufficiency; Adult; Aged; Corticotropin-Releasing Hormone; Female; Hormones; H | 1988 |
Reversible adrenal insufficiency induced by ketoconazole.
Topics: 17-Hydroxycorticosteroids; Adrenal Insufficiency; Cortodoxone; Cosyntropin; Humans; Hydrocortisone; | 1985 |
Effects of decreased adrenal corticosteroids: changes in sleep in normal subjects and patients with adrenal cortical insufficiency.
Topics: Addison Disease; Adrenal Insufficiency; Adult; Cortisone; Dexamethasone; Dose-Response Relationship, | 1974 |
Remission of Cushing's disease after administration of adrenocorticotropin.
Topics: 17-Hydroxycorticosteroids; Administration, Oral; Adrenal Glands; Adrenal Insufficiency; Adrenocortic | 1974 |
"Selective" pituitary insufficiency secondary to busulfan.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Insufficiency; Adrenocorticotropic Hormone; Aged | 1967 |
Adrenocortical insufficiency in spite of high corticosteroid excretion in a patient with thyrotoxicosis.
Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Insufficiency; Adrenocorticotropic Hormone; Adult; | 1968 |
Specific activity and sensitivity of strophanthin of the Na + +K + -activated ATPase in rats and guinea-pigs with hypoadrenalism.
Topics: Adenosine Triphosphatases; Adrenal Insufficiency; Adrenalectomy; Animals; Brain; Enzyme Activation; | 1972 |
Adrenocortical and pituitary function following long-term prednisolone treatment.
Topics: Adrenal Insufficiency; Adrenocorticotropic Hormone; Adult; Aged; Arthritis, Rheumatoid; Female; Huma | 1966 |
Sequential solvent extraction of urinary corticosteroids and its clinical application.
Topics: 17-Hydroxycorticosteroids; Adrenal Hyperplasia, Congenital; Adrenal Insufficiency; Adrenocorticotrop | 1967 |
[Functional evaluation of the pituitary gland with the metyrapone test and determination of ACTH in the blood].
Topics: Acromegaly; Adrenal Insufficiency; Adrenocorticotropic Hormone; Cushing Syndrome; Humans; Hypopituit | 1967 |
[Pituitary syndromes of diencephalic origin. Clinical application of pituitary stimulation tests].
Topics: 17-Hydroxycorticosteroids; Adrenal Gland Diseases; Adrenal Insufficiency; Adrenocorticotropic Hormon | 1968 |
[Clinical studies on the stimulation and suppression of the pituitary-adrenocortical system. 3. Studies on the pituitary adrenocortical suppression after long-term glucocorticoid treatment].
Topics: 17-Hydroxycorticosteroids; Adrenal Insufficiency; Adrenocorticotropic Hormone; Adult; Aged; Arthriti | 1968 |
[Present state of the dynamic studies of the adrenal cortex (excepting and aldosterone function)].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Addison Disease; Adrenal Gland Neoplasms; Adrenal Insuff | 1968 |
[Fractional determination of 4 types of neutral steroid glucuronides (11-deoxy-C-19 steroid, 11-deoxy-C-21 steroid, 11-oxy-C-19 steroid, 11-oxy-C-21 steroid) and 3 types of steroid glucuronides (11-deoxy-neutral steroid, pregnanediol, 11-oxy-neutral stero
Topics: Adrenal Insufficiency; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Adult; Castration; | 1969 |
Plasma corticotrophin levels in primary and secondary adrenocortical insufficiency.
Topics: Addison Disease; Adrenal Insufficiency; Adrenocorticotropic Hormone; Circadian Rhythm; Feedback; Hum | 1969 |
Hyponatremia in pituitary insufficiency.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Insufficiency; Adrenocorticotropic Hormone; Dexa | 1969 |
The function of the adrenal glands during prolonged corticosteroid therapy.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Glands; Adrenal Insufficiency; Adren | 1969 |
Adrenocorticotrophic-hormone deficiency in chronic myelogenous leukemia after treatment.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Insufficiency; Adrenocorticotropic H | 1970 |
[Diagnostic method and its clinical usefulness in hypothalamo-hypophyseo-adrenal insufficiency in children].
Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenal Insufficiency; Adrenocorticotropic Hormone; Child; Ch | 1969 |
[Control of the hypothalamic-hypophyseal-adrenal cortex regulatory zone with ACTH and the metopirone test in long-term glucocorticoid therapy].
Topics: Adolescent; Adrenal Insufficiency; Adrenocorticotropic Hormone; Adult; Child; Glucocorticoids; Human | 1970 |
Vasopressin in the diagnostic evaluation of pituitary and hypothalamic function.
Topics: Adolescent; Adrenal Cortex Hormones; Adrenal Insufficiency; Adrenocorticotropic Hormone; Adult; Aged | 1971 |
Tests of adrenocortical function.
Topics: Adrenal Gland Neoplasms; Adrenal Insufficiency; Adrenocorticotropic Hormone; Cushing Syndrome; Dexam | 1971 |
Inadequate adrenal reserve.
Topics: 17-Ketosteroids; Adrenal Insufficiency; Adrenocorticotropic Hormone; Aged; Deafness; Glucocorticoids | 1971 |
Adverse effects of large doses of medroxyprogesterone (MPA) in idiopathic isosexual precocity.
Topics: Adrenal Glands; Adrenal Insufficiency; Adrenocorticotropic Hormone; Body Height; Body Weight; Bone D | 1971 |
[Pituitary-adrenal function in the cirrhotic patient].
Topics: 17-Hydroxycorticosteroids; Adrenal Glands; Adrenal Insufficiency; Adrenocorticotropic Hormone; Circa | 1970 |
Plasma corticosteroids in primary and secondary adrenocortical insufficiency.
Topics: Addison Disease; Adrenal Cortex Hormones; Adrenal Insufficiency; Adrenocorticotropic Hormone; Adult; | 1972 |
[Function studies of the hypothalamus-anterior-pituitary-adrenal cortex system following surgery of cortisol-producing adrenal gland adenoma].
Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenal Gland Neoplasms; Adrenal Glands; Adrenal Insufficienc | 1972 |
[Urinary cortisol analysis in chronic hepatitis. In vitro test with H 3-cortisol].
Topics: Adrenal Insufficiency; Adrenocorticotropic Hormone; Chronic Disease; Hepatitis; Humans; Hydrocortiso | 1972 |
Iatrogenic Cushing's disease in a boy after misdiagnosis of salt-losing virilizing adrenal hyperplasia: impaired metyrapone response with failure of catch-up growth.
Topics: 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adrenal Insufficiency; Adrenocorticotropic Hormone | 1973 |
The effects of drug-induced adrenocortical deficiency and of mineralocorticoid drugs on anaphylaxis in the guinea-pig.
Topics: Adrenal Cortex Hormones; Adrenal Insufficiency; Adrenocorticotropic Hormone; Anaphylaxis; Animals; B | 1968 |
Adrenal and pituitary functions during long-term topical steroid therapy.
Topics: 17-Ketosteroids; Administration, Topical; Adrenal Insufficiency; Anti-Inflammatory Agents; Betametha | 1972 |
Comparative study of three tests for the assessment of hypothalamic-pituitary-adrenocortical function.
Topics: 11-Hydroxycorticosteroids; 17-Hydroxycorticosteroids; Adolescent; Adrenal Glands; Adrenal Insufficie | 1972 |
The mechanism of delayed biologic response following beryllium exposure.
Topics: Adrenal Insufficiency; Adrenalectomy; Animals; Beryllium; Body Weight; Bone and Bones; Chemical and | 1973 |
Adrenal insufficiency and electrophysiological measures of auditory sensitivity.
Topics: Action Potentials; Adrenal Insufficiency; Adrenalectomy; Animals; Auditory Perception; Brain Stem; C | 1973 |
[Secretion of cortisol, corticosterone, and 11-desoxycortisol in patients with primary adrenal gland insufficiency under basal conditions and during the metopirone test].
Topics: Adrenal Insufficiency; Carbon Isotopes; Corticosterone; Desoxycorticosterone; Humans; Hydrocortisone | 1971 |
[Extent of adrenal inhibition after corticosteroid treatment for varying periods. II. Study of lipolysis and the adrenal response, using the metopirone test].
Topics: Adrenal Cortex Hormones; Adrenal Glands; Adrenal Insufficiency; Child; Child, Preschool; Fatty Acids | 1968 |
A simplified metyrapone test with determination of plasma ll-deoxycortisol (Metyrapone test with plasma S).
Topics: 17-Hydroxycorticosteroids; Adrenal Gland Neoplasms; Adrenal Insufficiency; Adrenocortical Hyperfunct | 1969 |