metyrapone has been researched along with Adrenal Gland Hyperfunction in 59 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Excerpt | Relevance | Reference |
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"Clinical trial with a steroid suppressive agent, metyrapone, was carried out in 6 patients with treatment-resistant depression (3 patients with major depression and 3 with bipolar disorder)." | 5.08 | [Clinical effects of cortisol synthesis inhibition on treatment-resistant depression]. ( Iizuka, H; Kishimoto, A; Mizukawa, R; Nakamura, J, 1996) |
"The most common cause of endogenous Cushing's disease in children older than 7 years is ACTH-dependent Cushing's disease (85%)." | 2.45 | [Cushing's syndrome: special issues]. ( Goñi Iriarte, MJ, 2009) |
"Spontaneous hyperadrenocorticism is a common and well-recognised endocrine disorder occurring in dogs." | 2.40 | Diagnosis of hyperadrenocorticism in dogs as compared to human diagnostic methods: a review. ( Balogh, L; Huszenicza, G; Jánoki, GA; Kulcsár, M; Thuróczy, J, 1998) |
"We report three cases of long-term treatment of ectopic ACTH syndrome due to metastatic bronchial carcinoid, islet cell carcinoma, and malignant thymoma tumors." | 2.40 | Long-term medical treatment of ectopic ACTH syndrome. ( Comi, RJ; Gorden, P, 1998) |
"Non-iatrogenic Cushing's syndrome has been associated primarily with three entities: pituitary-dependent processes due to pituitary adenomas or microadenomas causing adrenal hyperplasia; pituitary-independent primary adrenal causes, predominantly unilateral adenomas, rarely multiple adenomas or adrenal carcinoma; ectopic sources of adrenocorticotropic hormone (ACTH) production." | 2.37 | Primary adrenocortical nodular dysplasia, a distinct subtype of Cushing's syndrome. Case report and review of the literature. ( Cathey, WJ; Larsen, JL; Odell, WD, 1986) |
"Treatment with metyrapone appeared to stabilize the cat metabolically and clinically prior to surgery." | 1.31 | Hyperadrenocorticism treated with metyrapone followed by bilateral adrenalectomy in a cat. ( Biller, DS; Moore, LE; Olsen, DE, 2000) |
"Metyrapone was administered orally at a dosage of 65 mg/kg of body weight, every 12 hours." | 1.29 | Use of metyrapone to treat pituitary-dependent hyperadrenocorticism in a cat with large cutaneous wounds. ( Daley, CA; Powers, RD; Schick, RO; Zerbe, CA, 1993) |
"In 15 patients with congenital adrenal hyperplasia, the corticotrophic and melanotrophic functions were evaluated by plasma ACTH and beta-MSH radioimmunoassay." | 1.26 | Corticotrophic and melanotrophic functions in congenital adrenal hyperplasia. ( Lombardi, G; Lupoli, G; Minozzi, M; Oliver, Ch, 1977) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 50 (84.75) | 18.7374 |
1990's | 6 (10.17) | 18.2507 |
2000's | 3 (5.08) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Goñi Iriarte, MJ | 1 |
GIROD, C | 1 |
RACADOT, J | 1 |
FERRARI, E | 1 |
PIOTTI, LE | 1 |
GOTH, E | 1 |
POLLAK, L | 1 |
NORMAN, N | 1 |
FAGLIA, G | 1 |
D ALONZO, R | 1 |
NORBIATO, G | 1 |
ORTHMANN, G | 1 |
LIUZZI, A | 1 |
TAKEDA, R | 1 |
MIYAHO, S | 1 |
MORIMOTO, S | 1 |
HASUI, K | 1 |
KANEDA, M | 1 |
NAGANO, T | 1 |
YOKOYAMA, T | 1 |
CERESA, F | 1 |
ANGELI, A | 1 |
STRUMIA, E | 1 |
LELONG, M | 1 |
CANLORBE, P | 1 |
BORNICHE, P | 1 |
JOB, JC | 1 |
SCHOLLER, R | 1 |
MAGGIOLO, J | 1 |
CASTIGLIONI, CA | 1 |
OLIVIERI, E | 1 |
IORI, E | 1 |
SOLA, OH | 1 |
VILANOVA, D | 1 |
HOFFMAN, C | 1 |
KOSANIK, M | 1 |
WAINER, AC | 1 |
TAMM, J | 1 |
Young, AH | 1 |
Daley, CA | 1 |
Zerbe, CA | 1 |
Schick, RO | 1 |
Powers, RD | 1 |
Iizuka, H | 1 |
Kishimoto, A | 1 |
Nakamura, J | 1 |
Mizukawa, R | 1 |
Thuróczy, J | 1 |
Balogh, L | 1 |
Huszenicza, G | 1 |
Jánoki, GA | 1 |
Kulcsár, M | 1 |
Comi, RJ | 1 |
Gorden, P | 1 |
Lyons, DM | 1 |
Wang, OJ | 1 |
Lindley, SE | 1 |
Levine, S | 1 |
Kalin, NH | 1 |
Schatzberg, AF | 1 |
Moore, LE | 1 |
Biller, DS | 1 |
Olsen, DE | 1 |
Lombardi, G | 2 |
Oliver, Ch | 1 |
Lupoli, G | 1 |
Minozzi, M | 2 |
Suzuki, S | 1 |
Curtius, HC | 1 |
Völlmin, J | 1 |
Zagalak, MJ | 1 |
Zachmann, M | 1 |
Starkova, NT | 1 |
Carballeira, A | 2 |
Fishman, LM | 2 |
Jacobi, JD | 1 |
Murphy, BE | 1 |
Sagara, Y | 2 |
Okatani, Y | 2 |
Larsen, JL | 1 |
Cathey, WJ | 1 |
Odell, WD | 1 |
Carey, RM | 1 |
Orth, DN | 1 |
Hartmann, WH | 1 |
Philbert, M | 1 |
Luton, JP | 2 |
Mathieu de Fossey, B | 1 |
Bricaire, H | 2 |
Martin, MM | 1 |
Hamman, BL | 1 |
Smilo, RP | 1 |
Earll, JM | 1 |
Forsham, PH | 1 |
Siegel, ET | 1 |
O'Brien, JB | 1 |
Pyle, L | 1 |
Schryver, HF | 1 |
Landon, J | 2 |
James, VH | 2 |
Peart, WS | 1 |
Wynn, V | 1 |
Greenwood, FC | 1 |
Materazzi, F | 1 |
Kinoshita, K | 1 |
Faggiano, M | 1 |
Salerno, M | 1 |
Nunziata, V | 1 |
Leprat, J | 1 |
Kubo, N | 1 |
Rayyis, SS | 1 |
Bethune, JE | 1 |
French, FS | 1 |
Macfie, JA | 1 |
Baggett, B | 1 |
Williams, TF | 1 |
Van Wyk, JJ | 1 |
Brun, J | 1 |
Revol, A | 1 |
Queneau, P | 1 |
Callard, IP | 1 |
Willard, E | 1 |
Raith, L | 2 |
Hamilton, W | 1 |
Gray, CE | 1 |
Cheng, SC | 1 |
Kenny, FM | 1 |
Franks, RC | 1 |
Reschini, E | 1 |
Giustina, G | 1 |
Filipp, G | 1 |
Mess, B | 1 |
Matthews, JI | 1 |
Fariss, BL | 1 |
Chertow, BS | 1 |
Howard, WB | 1 |
Leonard, JM | 1 |
Granner, DK | 1 |
Brown, JD | 1 |
Korenman, SG | 1 |
Rahandraha, T | 1 |
Skelton, FR | 1 |
Brownie, A | 1 |
Nickerson, PA | 1 |
Molteni, A | 1 |
Gallant, S | 1 |
Colby, HD | 1 |
Meikle, AW | 1 |
Jubiz, W | 1 |
Hutchings, MP | 1 |
West, CD | 1 |
Tyler, FH | 1 |
6 reviews available for metyrapone and Adrenal Gland Hyperfunction
Article | Year |
---|---|
[Cushing's syndrome: special issues].
Topics: Adolescent; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocortical Hyperfunction; Adult; Child; Cush | 2009 |
[SIGNIFICANCE OF PITUITARY AND ADRENAL CORTEX HORMONES IN DIABETES MELLITUS].
Topics: Adrenal Cortex Hormones; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Blood Chemical A | 1964 |
Antiglucocoticoid treatments for depression.
Topics: Adrenocortical Hyperfunction; Dehydroepiandrosterone; Depressive Disorder, Major; Enzyme Inhibitors; | 2006 |
Diagnosis of hyperadrenocorticism in dogs as compared to human diagnostic methods: a review.
Topics: Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Alkaline Phosphatase; Animals; Corticotro | 1998 |
Long-term medical treatment of ectopic ACTH syndrome.
Topics: ACTH Syndrome, Ectopic; Adolescent; Adrenocortical Hyperfunction; Aminoglutethimide; Antineoplastic | 1998 |
Primary adrenocortical nodular dysplasia, a distinct subtype of Cushing's syndrome. Case report and review of the literature.
Topics: Adolescent; Adrenal Cortex; Adrenal Hyperplasia, Congenital; Adrenalectomy; Adrenocortical Hyperfunc | 1986 |
2 trials available for metyrapone and Adrenal Gland Hyperfunction
Article | Year |
---|---|
[Clinical effects of cortisol synthesis inhibition on treatment-resistant depression].
Topics: Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Adult; Depression; Depression, Chemical; | 1996 |
Treatment of major depression with steroid suppressive drugs.
Topics: Adrenocortical Hyperfunction; Adult; Aged; Aminoglutethimide; Cushing Syndrome; Depressive Disorder; | 1991 |
51 other studies available for metyrapone and Adrenal Gland Hyperfunction
Article | Year |
---|---|
[EXPERIMENTAL IDENTIFICATION OF ANTERIOR PITUITARY CORTICOTROPIC CELLS IN THE MONKEY MACACUS IRUS F. CUV].
Topics: Adrenocortical Hyperfunction; Animals; Cell Biology; Dexamethasone; Haplorhini; Ketones; Metyrapone; | 1963 |
[DEMONSTRATION OF CORTICOTROPIC CELLS OF THE ADENOHYPOPHYSIS IN THE IMMATURE CAT TREATED WITH STEROIDOGENESIS INHIBITORS].
Topics: Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Cats; Histological Techniques; Histology; | 1963 |
[FUNCTIONAL EVALUATION OF THE PREHYPOPHYSIAL-CORTICOADRENAL SYSTEM IN PUERPERAL ADIPOSE HYPERSOMIA IN MALES].
Topics: 17-Ketosteroids; Adiposity; Adolescent; Adrenal Cortex Hormones; Adrenocortical Hyperfunction; Adren | 1963 |
[TESTING OF THE FUNCTION OF THE PITUITARY GLAND AND THE ADRENAL GLANDS WITH METOPIRONE].
Topics: 17-Ketosteroids; Addison Disease; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenal Glands; | 1963 |
[DIFFERENTIAL BIOCHEMICAL DIAGNOSIS OF ADRENOCORTICAL HYPERFUNCTION].
Topics: Adrenal Cortex Hormones; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Aldosterone; Dex | 1963 |
[SIGNIFICANCE OF THE EVALUATION OF URINARY PREGNANTRIOL IN SOME ADRENAL ENDOCRINE DISORDERS: FINDINGS IN BASAL CONDITIONS AND AFTER TREATMENTS STIMULATING OR INHIBITING THE ADRENAL CORTEX].
Topics: Adolescent; Adrenal Cortex; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenocortical Hyperfun | 1964 |
[OBSERVATIONS ON THE KINETICS OF THE "LIDDLE EFFECT" AND RELATED SEMEIOTIC-DIAGNOSTIC CONSIDERATIONS ON THE LIDDLE TEST].
Topics: Adrenal Cortex Hormones; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Humans; Ketones; | 1964 |
[THE METOPIRONE (SU-4885) TEST IN CHILDREN. RESULTS IN 150 PATHOLOGICAL CASES].
Topics: Adrenocortical Hyperfunction; Child; Goiter; Hypopituitarism; Infant; Infant Nutrition Disorders; Me | 1964 |
[EXPLORATION OF THE ACTH HYPOPHYSEAL RESERVE WITH METOPIRONE IN DIFFERENT ENDOCRINOPATHIES].
Topics: 17-Ketosteroids; Acromegaly; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Clinical Lab | 1963 |
[CONTRIBUTION TO THE FUNCTIONAL STUDY OF THE PITUITARY-ADRENAL AXIS WITH METHOPYRAPONE (2-METHYL-1,2-BIS(3-PYRIDYL)-1-PROPANONE)].
Topics: Adolescent; Adrenal Glands; Adrenocortical Hyperfunction; Child; Cushing Syndrome; Hirsutism; Humans | 1964 |
[ADRENAL CORTEX HYPERPLASIA ASSOCIATED WITH HYPERTROPHY OF THE THYMUS GLAND AND ACANTHOSIS NIGICANS IN A CHILD].
Topics: Acanthosis Nigricans; Adrenal Cortex; Adrenal Gland Diseases; Adrenocortical Hyperfunction; Adrenoco | 1964 |
[THE DIFFERENTIAL DIAGNOSIS OF CUSHING'S SYNDROME].
Topics: Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Cushing Syndrome | 1964 |
Use of metyrapone to treat pituitary-dependent hyperadrenocorticism in a cat with large cutaneous wounds.
Topics: Adrenalectomy; Adrenocortical Hyperfunction; Animals; Cat Diseases; Cats; Combined Modality Therapy; | 1993 |
Separation induced changes in squirrel monkey hypothalamic-pituitary-adrenal physiology resemble aspects of hypercortisolism in humans.
Topics: Adrenal Glands; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Animals; Anxiety, Separat | 1999 |
Hyperadrenocorticism treated with metyrapone followed by bilateral adrenalectomy in a cat.
Topics: Adrenalectomy; Adrenocortical Hyperfunction; Animals; Cat Diseases; Cats; Female; Metyrapone | 2000 |
Corticotrophic and melanotrophic functions in congenital adrenal hyperplasia.
Topics: Adolescent; Adrenal Hyperplasia, Congenital; Adrenocortical Hyperfunction; Adrenocorticotropic Hormo | 1977 |
[ACTH secretion and adrenocortical responsiveness in Cushing's syndrome due to adrenocortical hyperplasia (author's transl)].
Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenal Cortex; Adrenal Glands; Adrenalectomy; Adrenocortical | 1976 |
Gas chromatography of steroids and its clinical applications, including loading tests with deuterated compounds.
Topics: Adrenal Glands; Adrenocortical Hyperfunction; Adult; Androstanes; Child; Cholesterol; Chromatography | 1975 |
[Functional tests used in diagnosis of different forms of hypercorticism].
Topics: Adrenal Glands; Adrenocortical Hyperfunction; Cushing Syndrome; Dexamethasone; Dihydroxyphenylalanin | 1975 |
Dual sites of inhibition by metyrapone of human adrenal steroidogenesis: correlation of in vivo and in vitro studies.
Topics: Adenoma; Adrenal Cortex; Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adrenal Glands; Adrenoco | 1976 |
[Clinical significance of urinary tetrahydro-11-deoxycortisol analysis in endocrine tests of the adrenal cortex].
Topics: 17-Hydroxycorticosteroids; Adrenal Cortex Function Tests; Adrenal Insufficiency; Adrenocortical Hype | 1989 |
[Clinical significance of serum 11-deoxycortisol analysis in endocrine tests of the adrenal cortex].
Topics: 17-Hydroxycorticosteroids; Adrenal Cortex Function Tests; Adrenal Insufficiency; Adrenocortical Hype | 1989 |
Malignant melanoma with ectopic production of adrenocorticotropic hormone. Palliative treatment with inhibitors of adrenal steroid biosynthesis.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocortical Hyperfunction; Adrenocorticotropic Hormon | 1973 |
[Inhibitors of corticosteroid formation. I. The first adrenal cortex inhibitors].
Topics: Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocortical Hyperfunction; Anti | 1968 |
Patterns of urinary excretion of steroids in Cushing's syndrome.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; A | 1966 |
Suppression of tumorous adrenal hyperfunction by aminoglutethimide.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma; Adrenal Gland Neoplasms; Adrenocortical Hyperfu | 1967 |
Functional adrenocortical carcinoma in a dog.
Topics: 17-Ketosteroids; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; | 1967 |
Cushing's syndrome associated with a "corticotrophin"-producing bronchial neoplasm neoplasm (results of corticotrophin assays and of pituitary-adrenal function tests).
Topics: 17-Hydroxycorticosteroids; Adrenal Cortex Hormones; Adrenocortical Hyperfunction; Adrenocorticotropi | 1967 |
A fundamental defect of adrenocortical control in Cushing's disease.
Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenal Cortex Hormones; Adrenal Glands; Adrenalectomy; Adren | 1968 |
[Reichstein's S substance in humans].
Topics: Adenocarcinoma; Adenoma; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal Gland Neoplasms; A | 1966 |
[Gas chromatographic estimation of urinary pregnanetriol, pregnanetriolone and pregnanetetrole before and during administration of ACTH, metopirone and corticosteroids in patients with congenital adrenal hyperplasia].
Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Adrenocortical Hyperfunction; Adrenocorticotro | 1967 |
[Functional exploration of the adrenal cortex in basal and dynamic conditions in hypercorticism of the Cushing type].
Topics: 17-Ketosteroids; Adolescent; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenocortical Hyperfu | 1968 |
[Present state of the dynamic studies of the adrenal cortex (excepting and aldosterone function)].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Addison Disease; Adrenal Gland Neoplasms; Adrenal Insuff | 1968 |
[Fractional determination of 4 types of neutral steroid glucuronides (11-deoxy-C-19 steroid, 11-deoxy-C-21 steroid, 11-oxy-C-19 steroid, 11-oxy-C-21 steroid) and 3 types of steroid glucuronides (11-deoxy-neutral steroid, pregnanediol, 11-oxy-neutral stero
Topics: Adrenal Insufficiency; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Adult; Castration; | 1969 |
Radioimmunoassayable ACTH in dexamethasone nonsuppressible Cushing's syndrome.
Topics: Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Adult; Chemistry, Clinical; Cushing Syndr | 1969 |
Cushing's syndrome with a paradoxical response to dexamethasone.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma, Basophil; Adrenalectomy; Adrenocortical Hyperfu | 1969 |
[Broncho-pulmonary cancer with true or degraded hypercorticism].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocortical Hyperfunction; Adrenocorticotropic Hormon | 1969 |
Effects of intrahypothalamic betamethazone implants on adrenal function in male sceloporus cyanogenys.
Topics: Adrenal Glands; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Animals; Betamethasone; B | 1969 |
[Medical therapy of hyperadrenalism].
Topics: Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Aminoglutethimide; Cushing Syndrome; Huma | 1973 |
Urinary pregnanediol and pregnanetriol in the salt-losing and nonsalt-losing forms of C-21-hydroxylase deficiency.
Topics: Adolescent; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Aldosterone; Child; Child, Pr | 1972 |
Metabolism of (4-14C) cholesterol by human adrenal glands in vitro and its inhibition by metyrapone.
Topics: 17-Hydroxycorticosteroids; Adenoma; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenal Glands; | 1974 |
Use of corticosteroids.
Topics: Addison Disease; Administration, Oral; Adolescent; Adrenocortical Hyperfunction; Age Factors; Asthma | 1974 |
Screening tests for congenital adrenal hyperplasia.
Topics: 17-alpha-Hydroxypregnenolone; Adrenal Hyperplasia, Congenital; Adrenocortical Hyperfunction; Binding | 1972 |
Hypocholesterolaemia in hyperadrenal states.
Topics: 17-Ketosteroids; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Androstanes; Cholesterol; Fe | 1973 |
Role of the adrenocortical system in suppressing anaphylaxis after hypothalamic lesion.
Topics: Adrenal Glands; Adrenalectomy; Adrenocortical Hyperfunction; Aldosterone; Anaphylaxis; Animals; Anti | 1969 |
Adrenal adenoma with variable response to dexamethasone suppression and metyrapone stimulation.
Topics: 17-Hydroxycorticosteroids; Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocortical Hyperfun | 1972 |
[Drug therapy of adrenal gland hyperfunction].
Topics: Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Aminoglutethimide; A | 1972 |
Newer diagnostic tests to evaluate the hypothalamic pituitary adrenal axis.
Topics: Adrenocortical Hyperfunction; Dexamethasone; Humans; Metyrapone; Pituitary-Adrenal Function Tests | 1972 |
[Relation between the biosynthesis of cortisol and the level of blood urea in guinea pigs deficient in vitamin C].
Topics: Adrenocortical Hyperfunction; Animals; Ascorbic Acid Deficiency; Guinea Pigs; Hydrocortisone; Metyra | 1967 |
Adrenal cortical dysfunction as a basis for experimental hypertensive disease.
Topics: Adrenal Glands; Adrenocortical Hyperfunction; Anabolic Agents; Androgens; Animals; Blood Pressure; F | 1969 |
A simplified metyrapone test with determination of plasma ll-deoxycortisol (Metyrapone test with plasma S).
Topics: 17-Hydroxycorticosteroids; Adrenal Gland Neoplasms; Adrenal Insufficiency; Adrenocortical Hyperfunct | 1969 |