metyrapone has been researched along with Acute Post-Traumatic Stress Disorder in 13 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Relative to controls, women with PTSD had decreased ACTH and delta sleep responses to metyrapone." | 2.73 | Effects of metyrapone on hypothalamic-pituitary-adrenal axis and sleep in women with post-traumatic stress disorder. ( Lenoci, M; Marmar, CR; Metzler, T; Neylan, TC; Otte, C; Yehuda, R, 2007) |
| "Subjects with PTSD had higher raw cortisol and higher normed (baseline-related) ACTH and 11-deoxycortisol values after metyrapone independent of treatment with fludrocortisone or placebo." | 2.72 | Mineralocorticoid receptor function in posttraumatic stress disorder after pretreatment with metyrapone. ( Daneshkhah, S; Kellner, M; Kiefer, F; Muhtz, C; Otte, C; Wiedemann, K; Yassouridis, A, 2006) |
| " Dose-response studies using metyrapone and glucocorticoid agonists are needed to further investigate HPA axis regulation in PTSD." | 2.71 | Overnight metyrapone and combined dexamethasone/metyrapone tests in post-traumatic stress disorder: preliminary findings. ( Jahn, H; Kellner, M; Otte, C; Schick, M; Wiedemann, K; Yassouridis, A, 2004) |
| "Eleven GWV without PTSD, 18 GWV with PTSD and 15 healthy subjects not exposed to the Gulf War theater (non-exposed) underwent the metyrapone stimulation test, which inhibits cortisol synthesis, impairs cortisol-mediated negative feedback inhibition and in turn increases levels of ACTH and 11-deoxycortisol, a cortisol precursor." | 1.35 | Pituitary response to metyrapone in Gulf War veterans: relationship to deployment, PTSD and unexplained health symptoms. ( Golier, JA; Schmeidler, J; Yehuda, R, 2009) |
| "Metyrapone caused an increase in awakenings and a marked decrease in quantitative measures of delta sleep that was significantly greater in controls compared to PTSD." | 1.32 | Delta sleep response to metyrapone in post-traumatic stress disorder. ( Lenoci, M; Maglione, ML; Marmar, CR; Metzler, TJ; Neylan, TC; Otte, C; Rosenlicht, NZ; Schoenfeld, FB; Yehuda, R, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (61.54) | 29.6817 |
| 2010's | 5 (38.46) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Inslicht, SS | 2 |
| Rao, MN | 2 |
| Richards, A | 2 |
| O'Donovan, A | 2 |
| Gibson, CJ | 1 |
| Baum, T | 1 |
| Metzler, TJ | 3 |
| Neylan, TC | 5 |
| Zenko, MY | 1 |
| Baranova, KA | 1 |
| Rybnikova, EA | 1 |
| Ryoke, R | 1 |
| Yamada, K | 1 |
| Ichitani, Y | 1 |
| Madden, E | 1 |
| Talbot, LS | 1 |
| Rucker, E | 1 |
| Hauger, RL | 1 |
| Keller, SM | 1 |
| Schreiber, WB | 1 |
| Stanfield, BR | 1 |
| Knox, D | 1 |
| Golier, JA | 1 |
| Schmeidler, J | 1 |
| Yehuda, R | 5 |
| Lenoci, M | 2 |
| Maglione, ML | 1 |
| Rosenlicht, NZ | 1 |
| Otte, C | 5 |
| Schoenfeld, FB | 1 |
| Marmar, CR | 3 |
| Kellner, M | 2 |
| Yassouridis, A | 2 |
| Schick, M | 1 |
| Jahn, H | 1 |
| Wiedemann, K | 2 |
| Muhtz, C | 1 |
| Daneshkhah, S | 1 |
| Kiefer, F | 1 |
| Metzler, T | 1 |
| Kanter, ED | 1 |
| Wilkinson, CW | 1 |
| Radant, AD | 1 |
| Petrie, EC | 1 |
| Dobie, DJ | 1 |
| McFall, ME | 1 |
| Peskind, ER | 1 |
| Raskind, MA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Glucocorticoid and Mineralocorticoid Receptor Function in Post Traumatic Stress Disorder[NCT00046553] | 97 participants | Observational | 2002-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for metyrapone and Acute Post-Traumatic Stress Disorder
| Article | Year |
|---|---|
Neuroendocrine regulation of sleep disturbances in PTSD.
Topics: Corticotropin-Releasing Hormone; Delta Rhythm; Enzyme Inhibitors; Humans; Hypothalamo-Hypophyseal Sy | 2006 |
Biology of posttraumatic stress disorder.
Topics: Adrenocorticotropic Hormone; Circadian Rhythm; Corticotropin-Releasing Hormone; Dexamethasone; Down- | 2001 |
3 trials available for metyrapone and Acute Post-Traumatic Stress Disorder
| Article | Year |
|---|---|
Overnight metyrapone and combined dexamethasone/metyrapone tests in post-traumatic stress disorder: preliminary findings.
Topics: Adrenocorticotropic Hormone; Adult; Area Under Curve; Case-Control Studies; Cortodoxone; Dexamethaso | 2004 |
Mineralocorticoid receptor function in posttraumatic stress disorder after pretreatment with metyrapone.
Topics: Adrenocorticotropic Hormone; Adult; Analysis of Variance; Antimetabolites; Cortodoxone; Feedback, Ph | 2006 |
Effects of metyrapone on hypothalamic-pituitary-adrenal axis and sleep in women with post-traumatic stress disorder.
Topics: Adrenocorticotropic Hormone; Adult; Analysis of Variance; Cortodoxone; Enzyme Inhibitors; Female; Hu | 2007 |
8 other studies available for metyrapone and Acute Post-Traumatic Stress Disorder
| Article | Year |
|---|---|
Sleep and hypothalamic pituitary adrenal axis responses to metyrapone in posttraumatic stress disorder.
Topics: Adrenocorticotropic Hormone; Adult; Corticotropin-Releasing Hormone; Cross-Sectional Studies; Female | 2018 |
Pathogenetic Role of the Stress-induced Release of Glucocorticoid Hormones in the Development of Post-traumatic Stress Disorder: An Experimental Study.
Topics: Animals; Enzyme Inhibitors; Glucocorticoids; Ischemic Preconditioning; Male; Metyrapone; Rats; Rats, | 2018 |
Long-term effects of traumatic stress on subsequent contextual fear conditioning in rats.
Topics: Animals; Conditioning, Psychological; Corticosterone; Electroshock; Fear; Male; Metyrapone; Random A | 2014 |
Sex differences in neurosteroid and hormonal responses to metyrapone in posttraumatic stress disorder.
Topics: Adrenocorticotropic Hormone; Adult; Enzyme Inhibitors; Feedback, Physiological; Female; Humans; Hydr | 2014 |
Inhibiting corticosterone synthesis during fear memory formation exacerbates cued fear extinction memory deficits within the single prolonged stress model.
Topics: Animals; Conditioning, Psychological; Corticosterone; Cues; Disease Models, Animal; Enzyme Inhibitor | 2015 |
Pituitary response to metyrapone in Gulf War veterans: relationship to deployment, PTSD and unexplained health symptoms.
Topics: Adrenocorticotropic Hormone; Adult; Cortodoxone; Gulf War; Health Status; Humans; Hydrocortisone; Ma | 2009 |
Delta sleep response to metyrapone in post-traumatic stress disorder.
Topics: Adrenocorticotropic Hormone; Adult; Case-Control Studies; Cortodoxone; Delta Rhythm; Electroencephal | 2003 |
Glucocorticoid feedback sensitivity and adrenocortical responsiveness in posttraumatic stress disorder.
Topics: Adrenocorticotropic Hormone; Dehydroepiandrosterone; Feedback; Humans; Hydrocortisone; Hypothalamo-H | 2001 |