Compounds > metyrapone
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metyrapone and Acromegaly

metyrapone has been researched along with Acromegaly in 36 studies

Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.

Acromegaly: A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of the FACE; lower jaw (PROGNATHISM); hands; FEET; HEAD; and THORAX. The most common etiology is a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. (From Joynt, Clinical Neurology, 1992, Ch36, pp79-80)

Research Excerpts

ExcerptRelevanceReference
" Serum deoxycorticosterone rose in healthy subjects upon injection of ACTH, after induction of insulin hypoglycemia and after administration of metyrapone, while the rise was absent or blunted in patients with Addison's disease and in patients with pituitary failure."3.65Radioimmunoassay of serum deoxycorticosterone: normal values and changes of serum deoxycorticosterone after adrenal stimulation. ( Harendt, H; Oelkers, W; Schöneshöfer, M, 1975)

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-199036 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
KAPLAN, NM2
JARPA, A1
AVILA, R1
DONOSO, J1
MEDINA, M1
FERRARI, E1
PIOTTI, LE1
MOLINATTI, GM2
CAMANNI, F1
MASSARA, F2
MAGGIOLO, J1
CASTIGLIONI, CA1
OLIVIERI, E1
MONTERVINO, C1
MARINOSCI, A1
DONATI, L1
NUZZI, R1
IACOBELLI, A1
MCCULLAGH, EP1
FELDSTEIN, MA1
TWEED, DC1
DOHN, DF1
BLEASEL, K1
LAZARUS, L1
Nishida, S2
Ando, M1
Katsuki, S2
Streeten, DH1
Anderson, GH1
Dalakos, TG1
Seeley, D1
Mallov, JS1
Eusebio, R1
Sunderlin, FS1
Badawy, SZ1
King, RB1
Schöneshöfer, M1
Oelkers, W1
Harendt, H1
Hsu, TH1
Wiedemann, E1
Saito, T1
Linfoot, JA1
Li, CH1
Waldhäusl, WK1
Rath, F1
Caplan, RH1
Dobben, GD1
Mautalen, CA1
Mellinger, RC1
Kozak, GP1
Vagnucci, AI1
Lauler, DP2
Thorn, GW2
Krotkiewski, M1
Zelaznowska, B1
Zembrzuska, Z1
Ruzyllo, E1
Isidori, A1
Frajese, G1
Dondero, F1
Tucci, JR1
Espiner, EA1
Jagger, PI1
Rinne, UK1
Losana, O1
Olivetti, M1
Cushman, P1
Hilton, JG1
Bonanni, G1
Spark, RF1
Lundberg, PO2
Wide, L1
Faglia, G1
Ambrosi, B1
Beck-Peccoz, P1
Travaglini, P1
Charro, AL1
Hofeldt, FD2
Becker, N2
Levin, SR2
Forsham, PH2
Schneider, V1
Karam, JH1
Seymour, RJ1
Adams, JE1
Kley, HK1
Krüskemper, HL1
Jacobs, HS1
Nabarro, JD1
Feurle, G1
Reisert, PM1
Emrich, D1
König, A1
Bushe, KA1
Tada, T1
Hugosson, R1

Reviews

2 reviews available for metyrapone and Acromegaly

ArticleYear
[METHODOLOGICAL DATA ON THE DYNAMIC EVALUATION OF THE DIENCEPHALON-ANTERIOR PITUITARY-ADRENAL CORTEX SYSTEM].
    Archivio per le scienze mediche, 1964, Volume: 117

    Topics: Acromegaly; Addison Disease; Adrenal Cortex; Adrenocorticotropic Hormone; Cushing Syndrome; Dexameth

1964
Normal and abnormal function of the hypothalamic-pituitary-adrenocortical system in man.
    Endocrine reviews, 1984,Summer, Volume: 5, Issue:3

    Topics: 17-Hydroxycorticosteroids; Acromegaly; Adenoma, Chromophobe; Adolescent; Adrenocorticotropic Hormone

1984

Trials

1 trial available for metyrapone and Acromegaly

ArticleYear
Vasopressin test in central nervous system-pituitary disorders.
    Neuroendocrinology, 1968, Volume: 3, Issue:4

    Topics: 17-Hydroxycorticosteroids; Acromegaly; Adenoma, Chromophobe; Adrenal Glands; Adrenocorticotropic Hor

1968

Other Studies

33 other studies available for metyrapone and Acromegaly

ArticleYear
ASSESSMENT OF PITUITARY ACTH SECRETORY CAPACITY WITH METOPIRONE: 1. INTERPRETATION.
    The Journal of clinical endocrinology and metabolism, 1963, Volume: 23

    Topics: Acromegaly; Adenoma; Adenoma, Acidophil; Adenoma, Chromophobe; Adrenal Cortex Hormones; Adrenocortic

1963
ASSESSMENT OF PITUITARY ACTH SECRETORY CAPACITY WITH METOPIRONE: II. COMPARISON WITH OTHER TESTS.
    The Journal of clinical endocrinology and metabolism, 1963, Volume: 23

    Topics: Acromegaly; Adenoma; Adenoma, Chromophobe; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Art

1963
[COMPARATIVE STUDY OF 2 METHODS OF MEASURING HYPOPHYSEAL CORTICOTROPIN RESERVE].
    Revista medica de Chile, 1963, Volume: 91

    Topics: 17-Ketosteroids; Acromegaly; Adrenocorticotropic Hormone; Biochemical Phenomena; Biochemistry; Chlor

1963
[INDIRECT EVALUATION OF CORTICOTROPIN ACTIVITY IN VARIOUS SITUATIONS OF PITUITARY-ADRENAL PHYSIOPATHOLOGY].
    Minerva medica, 1964, Feb-21, Volume: 55

    Topics: Acromegaly; Adrenocorticotropic Hormone; Anorexia Nervosa; Cushing Syndrome; Dexamethasone; Humans;

1964
[EXPLORATION OF THE ACTH HYPOPHYSEAL RESERVE WITH METOPIRONE IN DIFFERENT ENDOCRINOPATHIES].
    Anales de la Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay, 1963, Volume: 48

    Topics: 17-Ketosteroids; Acromegaly; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Clinical Lab

1963
[THE INCRETORY DYNAMICS OF THE ADRENAL CORTEX IN ACROMEGALY].
    Folia endocrinologica, 1964, Volume: 17

    Topics: Acromegaly; Adrenal Cortex; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Body Fluids; Keton

1964
A STUDY OF PITUITARY FUNCTION AFTER INTRASELLAR IMPLANTATION OF 90YTTRIUM.
    The Journal of clinical endocrinology and metabolism, 1965, Volume: 25

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Basal Metabolism; Breast Neoplasms; Cushing

1965
CRYOGENIC HYPOPHYSECTOMY.
    The Medical journal of Australia, 1965, Jul-24, Volume: 2, Issue:4

    Topics: Acromegaly; Betamethasone; Breast Neoplasms; Cryosurgery; Diabetic Retinopathy; Drug Therapy; Humans

1965
[Metopirone test and lateral dimensions of the sella turcica in pituitary tumor].
    Horumon to rinsho. Clinical endocrinology, 1966, Volume: 14, Issue:11

    Topics: Acromegaly; Adenoma, Chromophobe; Adolescent; Adult; Craniopharyngioma; Diagnosis, Differential; Fem

1966
Radioimmunoassay of serum deoxycorticosterone: normal values and changes of serum deoxycorticosterone after adrenal stimulation.
    Zeitschrift fur klinische Chemie und klinische Biochemie, 1975, Volume: 13, Issue:4

    Topics: Acromegaly; Addison Disease; Adrenocorticotropic Hormone; Adult; Chromatography, Paper; Desoxycortic

1975
Potentiation of the hypothalamic-pituitary-adrenal response to metyrapone by L-DOPA in acromegalic patients.
    Clinical endocrinology, 1978, Volume: 8, Issue:1

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Adult; Cortodoxone; Female; Humans; Hypothal

1978
Radioimmunoassay of human beta-lipotropin in unextracted plasma.
    The Journal of clinical endocrinology and metabolism, 1977, Volume: 45, Issue:5

    Topics: Acromegaly; beta-Lipotropin; Cushing Syndrome; Female; Humans; Hypopituitarism; Immune Sera; Male; M

1977
Development of antibodies to human growth hormone (HGH) in children of short stature treated with HGH.
    Acta endocrinologica, 1971, Volume: 68, Issue:2

    Topics: Acromegaly; Adolescent; Antibody Formation; Body Height; Child; Cross Reactions; Female; Glucose Tol

1971
Endocrine studies in patients with the "empty sella syndrome".
    Archives of internal medicine, 1969, Volume: 123, Issue:6

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Adult; Arginine; Basal Metabolism; Cerebral

1969
Nonsuppressible adrenocortical function in a patient with untreated acromegaly.
    The Journal of clinical endocrinology and metabolism, 1965, Volume: 25, Issue:11

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Adrenal Glands; Adrenocorticotropic Hormone;

1965
Acromegaly pre- and postpituitary irradiation.
    Metabolism: clinical and experimental, 1966, Volume: 15, Issue:4

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Adrenocorticotropic Hormone; Adult; Biopsy;

1966
[Behavior of the adrenal reserve and ACTH pituitary reserve and attempted ACTH block in treated and untreated acromegalic cases].
    Polskie Archiwum Medycyny Wewnetrznej, 1966, Volume: 36, Issue:6

    Topics: Acromegaly; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Dexamethasone; Female; Humans; Mal

1966
[Functional evaluation of the pituitary gland with the metyrapone test and determination of ACTH in the blood].
    Folia endocrinologica, 1967, Volume: 20, Issue:2

    Topics: Acromegaly; Adrenal Insufficiency; Adrenocorticotropic Hormone; Cushing Syndrome; Humans; Hypopituit

1967
Vasopressin in the evaluation of pituitary-adrenal function.
    Annals of internal medicine, 1968, Volume: 69, Issue:2

    Topics: Acromegaly; Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Adult; Anorex

1968
[Aspects of hypophyseal and adrenocortical function in acromegaly].
    Folia endocrinologica, 1968, Volume: 21, Issue:3

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Adrenal Glands; Adrenocorticotropic Hormone;

1968
Studies of metyrapone responses in patients with pituitary disease.
    The Journal of endocrinology, 1969, Volume: 43, Issue:3

    Topics: 17-Hydroxycorticosteroids; Acromegaly; Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Horm

1969
[Evaluation of the pituitary ACTH reserve in patients irradiated for cerebral neoplasms].
    Nuntius radiologicus, 1968, Volume: 34, Issue:5

    Topics: Acromegaly; Adrenocorticotropic Hormone; Adult; Astrocytoma; Brain Neoplasms; Cushing Syndrome; Fema

1968
Simplified assessment of pituitary-adrenal reserve. Measurement of serum 11-deoxycortisol and cortisol after metyrapone.
    Annals of internal medicine, 1971, Volume: 75, Issue:5

    Topics: Acromegaly; Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Biotransformation; Child; Child, P

1971
The response to TRH, LH-RH, metyrapone and vasopressin in patients with hypothalamo-pituitary disorders.
    European journal of clinical investigation, 1973, Volume: 3, Issue:1

    Topics: Acromegaly; Adenoma, Acidophil; Adenoma, Chromophobe; Adult; Brain Neoplasms; Craniopharyngioma; Dia

1973
Hypothalamic-pituitary-adrenal function in patients with pituitary tumours.
    Acta endocrinologica, 1973, Volume: 73, Issue:2

    Topics: 17-Hydroxycorticosteroids; Acromegaly; Adenoma, Chromophobe; Adolescent; Adrenal Glands; Adrenocorti

1973
Adrenocortical function in acromegaly.
    The American journal of the medical sciences, 1973, Volume: 266, Issue:3

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Adrenal Glands; Adrenocorticotropic Hormone;

1973
Cryohypophysectomy for acromegaly. Factors associated with altered endocrine function and carbohydrate metabolism.
    The American journal of medicine, 1974, Volume: 57, Issue:4

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Administration, Oral; Adrenal Glands; Adult;

1974
[Performance and interpretation of a shortened metyrapone test].
    Klinische Wochenschrift, 1972, Nov-15, Volume: 50, Issue:22

    Topics: 11-Hydroxycorticosteroids; Acromegaly; Adolescent; Adult; Aged; Circadian Rhythm; Diabetes Mellitus;

1972
Tests of hypothalamic-pituitary-adrenal function in man.
    The Quarterly journal of medicine, 1969, Volume: 38, Issue:152

    Topics: Acromegaly; Adrenal Glands; Adult; Aged; Cushing Syndrome; Female; Fever; Glucocorticoids; Growth Ho

1969
[Clinical and endocrinologic diagnosis of pituitary and suprasellar tumors].
    Deutsche medizinische Wochenschrift (1946), 1970, May-08, Volume: 95, Issue:19

    Topics: Acromegaly; Adenoma, Chromophobe; Craniopharyngioma; Female; Headache; Humans; Hypogonadism; Insulin

1970
[Hypothalamo-hypophyseo-adrenocortical response to insulin-induced hypoglycemia].
    Nihon Naibunpi Gakkai zasshi, 1967, Nov-20, Volume: 43, Issue:8

    Topics: Acromegaly; Adenoma, Chromophobe; Adrenal Cortex Hormones; Adult; Blood Glucose; Craniopharyngioma;

1967
[Clinical studies on urinary 17-ketogenic steroid fractions. 3. SU-4885 test in normal subjects and the patients with various endocrine disorders].
    Nihon Naibunpi Gakkai zasshi, 1968, Mar-20, Volume: 43, Issue:12

    Topics: 17-Hydroxycorticosteroids; Acromegaly; Adenoma; Adolescent; Adrenal Cortex Hormones; Adrenal Gland N

1968
Application of the metopirone test to tumors in the region of the sella turcica.
    Journal of neurosurgery, 1966, Volume: 25, Issue:5

    Topics: Acromegaly; Adenoma, Chromophobe; Adolescent; Adult; Aged; Brain Neoplasms; Child; Female; Humans; M

1966