Page last updated: 2024-10-31

metyrapone and ACTH Syndrome, Ectopic

metyrapone has been researched along with ACTH Syndrome, Ectopic in 30 studies

Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.

ACTH Syndrome, Ectopic: Symptom complex due to ACTH production by non-pituitary neoplasms.

Research Excerpts

ExcerptRelevanceReference
"Fifteen patients with endogenous Cushing's syndrome were treated with metyrapone and/or amino-glutethimide."9.05Aminoglutethimide and metyrapone in the management of Cushing's syndrome. ( Adamson, U; Sjöberg, HE; Thorén, M, 1985)
"We wished to develop optimal criteria for interpreting the single-dose overnight metyrapone test and to compare the diagnostic efficiency of the overnight and the standard 6-dose metyrapone tests for the differential diagnosis of ACTH-dependent Cushing's syndrome."7.69A comparison of the overnight and the standard metyrapone test for the differential diagnosis of adrenocorticotrophin-dependent Cushing's syndrome. ( Avgerinos, PC; Cutler, GB; Nieman, LK; Oldfield, EH, 1996)
"18 patients were studied on 21 occasions: three with Cushing's disease without metyrapone treatment prior to IPSS (M-), 11 with Cushing's disease with metyrapone pretreatment (M+), three with ectopic ACTH syndrome, and one with pseudo-Cushing's syndrome."7.69Metyrapone pre-treated inferior petrosal sinus sampling in the differential diagnosis of ACTH-dependent Cushing's syndrome. ( Atkinson, RL; Cameron, DP; Cuneo, RC; Harper, J; Lee, W; Mitchell, K; Salkield, I; Ward, G, 1997)
"To analyse the clinical and biochemical effects of metyrapone in the treatment of Cushing's syndrome."7.68Short and long-term responses to metyrapone in the medical management of 91 patients with Cushing's syndrome. ( Besser, GM; Grossman, AB; Howlett, TA; Perry, L; Rees, LH; Trainer, PJ; Verhelst, JA; Wass, JA, 1991)
"Cushing's syndrome due to bronchial carcinoid tumors that secrete adrenocorticotropin (ACTH) may be difficult to distinguish from pituitary Cushing's disease, since the responses to dexamethasone and metyrapone are sometimes similar."7.67Ectopic ACTH syndrome caused by a bronchial carcinoid tumor responsive to dexamethasone, metyrapone, and corticotropin-releasing factor. ( Abboud, C; Carey, RM; Carney, JA; Malchoff, CD; Orth, DN; Pairolero, PC, 1988)
"Fifteen patients with endogenous Cushing's syndrome were treated with metyrapone and/or amino-glutethimide."5.05Aminoglutethimide and metyrapone in the management of Cushing's syndrome. ( Adamson, U; Sjöberg, HE; Thorén, M, 1985)
"We wished to develop optimal criteria for interpreting the single-dose overnight metyrapone test and to compare the diagnostic efficiency of the overnight and the standard 6-dose metyrapone tests for the differential diagnosis of ACTH-dependent Cushing's syndrome."3.69A comparison of the overnight and the standard metyrapone test for the differential diagnosis of adrenocorticotrophin-dependent Cushing's syndrome. ( Avgerinos, PC; Cutler, GB; Nieman, LK; Oldfield, EH, 1996)
"18 patients were studied on 21 occasions: three with Cushing's disease without metyrapone treatment prior to IPSS (M-), 11 with Cushing's disease with metyrapone pretreatment (M+), three with ectopic ACTH syndrome, and one with pseudo-Cushing's syndrome."3.69Metyrapone pre-treated inferior petrosal sinus sampling in the differential diagnosis of ACTH-dependent Cushing's syndrome. ( Atkinson, RL; Cameron, DP; Cuneo, RC; Harper, J; Lee, W; Mitchell, K; Salkield, I; Ward, G, 1997)
"To analyse the clinical and biochemical effects of metyrapone in the treatment of Cushing's syndrome."3.68Short and long-term responses to metyrapone in the medical management of 91 patients with Cushing's syndrome. ( Besser, GM; Grossman, AB; Howlett, TA; Perry, L; Rees, LH; Trainer, PJ; Verhelst, JA; Wass, JA, 1991)
"Cushing's syndrome due to bronchial carcinoid tumors that secrete adrenocorticotropin (ACTH) may be difficult to distinguish from pituitary Cushing's disease, since the responses to dexamethasone and metyrapone are sometimes similar."3.67Ectopic ACTH syndrome caused by a bronchial carcinoid tumor responsive to dexamethasone, metyrapone, and corticotropin-releasing factor. ( Abboud, C; Carey, RM; Carney, JA; Malchoff, CD; Orth, DN; Pairolero, PC, 1988)
" Conservative treatment with metyrapone suppressed the Cushing syndrome."3.66[Successful conservative treatment of bronchial carcinoid with Cushing's syndrome due to ectopic ACTH production]. ( Euler, HH; Herrlinger, JD; Kirmse, L; Kleine, L; Löffler, H; Müller-Hermelink, HK, 1983)
"Treatment with metyrapone was started before pituitary surgery."2.66Pneumocystis pneumonia can complicate medical treatment of hypercortisolism even in outpatients with Cushing's disease. ( Carreau, A; Chabre, O; Cristante, J; Lepelley, M; Mallaret, M, 2020)
"ACTH-dependent Cushing's syndrome is a heterogeneous disorder requiring a multidisciplinary and individualized approach to patient management."2.44Treatment of adrenocorticotropin-dependent Cushing's syndrome: a consensus statement. ( Bertagna, X; Bertherat, J; Biller, BM; Boscaro, M; Buchfelder, M; Colao, A; Grossman, AB; Hermus, AR; Hofland, LJ; Klibanski, A; Lacroix, A; Lindsay, JR; Melmed, S; Newell-Price, J; Nieman, LK; Petersenn, S; Sonino, N; Stalla, GK; Stewart, PM; Swearingen, B; Vance, ML; Wass, JA, 2008)
"We report three cases of long-term treatment of ectopic ACTH syndrome due to metastatic bronchial carcinoid, islet cell carcinoma, and malignant thymoma tumors."2.40Long-term medical treatment of ectopic ACTH syndrome. ( Comi, RJ; Gorden, P, 1998)
"Imaging tests by CT/MRI identified the tumors in 8 of 16 (50%), in 4 of 11 (36%) and 4 of 6 (66."1.36Clinical features and management of ectopic ACTH syndrome at a single institute in Japan. ( Doi, M; Hirata, Y; Izumiyama, H; Sugiyama, T; Yoshimoto, T, 2010)
"Why some bronchial carcinoid tumours are responsive is unknown but it could be because of co-secretion of corticotrophin releasing factor (CRF) and/or expression of glucocorticoid receptors."1.29Glucocorticoid responsive ACTH secreting bronchial carcinoid tumours contain high concentrations of glucocorticoid receptors. ( Donald, RA; Espiner, EA; Florkowski, CM; Lewis, JG; Wittert, GA, 1994)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19909 (30.00)18.7374
1990's11 (36.67)18.2507
2000's3 (10.00)29.6817
2010's5 (16.67)24.3611
2020's2 (6.67)2.80

Authors

AuthorsStudies
Saishouji, F1
Maeda, S1
Hamada, H1
Kimura, N1
Tamanoi, A1
Nishida, S1
Sakaguchi, M1
Igata, M1
Yokoo, K1
Kawakami, F1
Araki, E1
Kondo, T1
Cristante, J1
Lepelley, M1
Mallaret, M1
Carreau, A1
Chabre, O1
Iwayama, H1
Hirase, S1
Nomura, Y1
Ito, T1
Morita, H1
Otake, K1
Okumura, A1
Takagi, J1
Corcuff, JB1
Young, J1
Masquefa-Giraud, P1
Chanson, P1
Baudin, E1
Tabarin, A1
Oda, N1
Miyahara, N1
Tabata, M1
Minami, D1
Ninomiya, K1
Kanehiro, A1
Komatsubara, M1
Inagaki, K1
Tanimoto, M1
Kiura, K1
Doi, M1
Sugiyama, T1
Izumiyama, H1
Yoshimoto, T1
Hirata, Y1
Aziz, SI1
Khattak, MA1
Usmani, Z1
Ladipeerla, N1
Pittman, K1
Kawashima, T1
Oda, M1
Kuno, T1
Ueki, H1
Yamada, S1
Hisatomi, A1
Mizoguchi, Y1
Kajiume, T1
Miyagawa, S1
Okada, S1
Nishi, Y1
Kobayashi, M1
Biller, BM1
Grossman, AB2
Stewart, PM1
Melmed, S1
Bertagna, X1
Bertherat, J1
Buchfelder, M1
Colao, A1
Hermus, AR1
Hofland, LJ1
Klibanski, A1
Lacroix, A1
Lindsay, JR1
Newell-Price, J2
Nieman, LK2
Petersenn, S1
Sonino, N1
Stalla, GK1
Swearingen, B1
Vance, ML1
Wass, JA2
Boscaro, M1
Hiramatsu, R1
Shimada, T1
Sato, T1
Herrlinger, JD1
Euler, HH1
Kleine, L1
Kirmse, L1
Müller-Hermelink, HK1
Löffler, H1
Wilson, RE1
Orth, DN2
Nicholson, WE1
Mount, CD1
Bertagna, XY1
Florkowski, CM1
Wittert, GA1
Lewis, JG1
Donald, RA1
Espiner, EA1
Avgerinos, PC1
Oldfield, EH1
Cutler, GB1
Horiba, N1
Suda, T1
Tanaka, K1
Toriumi, M1
Itoh, S1
Ogino, Y1
Cuneo, RC1
Lee, W1
Harper, J1
Mitchell, K1
Ward, G1
Atkinson, RL1
Salkield, I1
Cameron, DP1
Trainer, P1
Besser, M1
Grossman, A1
Comi, RJ1
Gorden, P1
Sanno, N1
Tahara, S1
Yoshida, Y1
Onose, H1
Wakabayashi, I1
Teramoto, A1
Puig, J1
Wägner, A1
Caballero, A1
Rodríguez-Espinosa, J1
Webb, SM1
Verhelst, JA1
Trainer, PJ1
Howlett, TA1
Perry, L1
Rees, LH1
Besser, GM1
Blunt, SB2
Sandler, LM1
Burrin, JM2
Joplin, GF2
Raff, H1
Findling, JW1
Pirmohamed, M1
Chatterjee, VK1
Allison, DJ1
Malchoff, CD1
Abboud, C1
Carney, JA1
Pairolero, PC1
Carey, RM1
Cagliero, E1
Lorenzi, M1
Schteingart, DE1
Lloyd, RV1
Akil, H1
Chandler, WF1
Ibarra-Perez, G1
Rosen, SG1
Ogletree, R1
Thorén, M1
Adamson, U1
Sjöberg, HE1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Treatment of Pituitary Cushing Disease With a Selective CDK Inhibitor, R-roscovitine[NCT02160730]Phase 24 participants (Actual)Interventional2014-05-31Terminated (stopped due to NIH grant ended.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants That Experience Changes in Clinical Signs of Hypercortisolemia

The number of participants that achieved a urinary free cortisol level above the upper limit of the normal range but reduced by ≥50% from baseline at week 4. (NCT02160730)
Timeframe: Baseline, Week 4

InterventionParticipants (Count of Participants)
R-roscovitine2

Number of Participants That Have a Visible Change in Tumor Size

A visible change in tumor size as determined by the investigator after reviewing MRI reports between baseline and 4 weeks of treatment. (NCT02160730)
Timeframe: Baseline, 4 weeks

InterventionParticipants (Count of Participants)
R-roscovitine0

Number of Participants With a Normalized 24 Hour Urinary Free Cortisol After 4 Weeks

"To evaluate the efficacy of R-roscovitine 400 mg oral administration twice daily for 4 days every week for total of 4 weeks on normalizing 24 hour urinary free cortisol (24 h UFC) levels in CD patients. Normalizing is defined as having urine free cortisol levels within the normal range for that lab value." (NCT02160730)
Timeframe: Baseline, 4 weeks

InterventionParticipants (Count of Participants)
R-roscovitine0

Number of Participants With Adverse Events

The number of participants that experience an adverse event between baseline and study end likely related to study drug as a measure of safety and tolerability. (NCT02160730)
Timeframe: Baseline, 4 weeks

InterventionParticipants (Count of Participants)
R-roscovitine2

Change in Clinical Symptoms

Change in typical Cushing's syndrome clinical signs and symptoms defined by mean weight at baseline and 4 weeks. (NCT02160730)
Timeframe: Baseline, 4 weeks

Interventionlbs (Mean)
Baseline4 Weeks
R-roscovitine217217.4

Change in Diastolic Blood Pressure

Mean diastolic blood pressure between baseline and 4 weeks. (NCT02160730)
Timeframe: Baseline, 4 weeks

InterventionmmHg (Mean)
Baseline4 Weeks
R-roscovitine76.571

Change in Mean HbA1c Levels Between Baseline and 4 Weeks

HbA1c levels are measured at baseline and at study end, these are averaged across all subjects. (NCT02160730)
Timeframe: Baseline, 4 Weeks

InterventionPercentage (Mean)
BaselineStudy End-4 weeks
R-roscovitine6.97

Change in Systolic Blood Pressure

Mean change in systolic blood pressure between baseline and 4 weeks. (NCT02160730)
Timeframe: Baseline, 4 weeks

InterventionmmHg (Mean)
Baseline4 weeks
R-roscovitine150.3128.3

Changes in Serum Cortisol Between Baseline and 4 Weeks

Mean serum cortisol values at baseline and 4 weeks (NCT02160730)
Timeframe: Baseline, 4 weeks

Interventionmg/dL (Mean)
Baseline4 Weeks
R-roscovitine25.627.1

Fasting Glucose at Baseline and 4 Weeks

Mean change between baseline and week 4 of fasting blood glucose levels. (NCT02160730)
Timeframe: Baseline, 4 Weeks

Interventiong/dL (Mean)
Baseline4 weeks
R-roscovitine121.4104.3

Plasma ACTH at Baseline and 4 Weeks

Mean change in Plasma ACTH between baseline and 4 weeks. (NCT02160730)
Timeframe: Baseline, 4 weeks

Interventionpg/mL (Mean)
Baseline4 weeks
R-roscovitine79.379.9

Reviews

6 reviews available for metyrapone and ACTH Syndrome, Ectopic

ArticleYear
Pneumocystis pneumonia can complicate medical treatment of hypercortisolism even in outpatients with Cushing's disease.
    Annales d'endocrinologie, 2020, Volume: 81, Issue:6

    Topics: ACTH Syndrome, Ectopic; Adult; Aged; Aged, 80 and over; Cushing Syndrome; Humans; Immunologic Defici

2020
Treatment of adrenocorticotropin-dependent Cushing's syndrome: a consensus statement.
    The Journal of clinical endocrinology and metabolism, 2008, Volume: 93, Issue:7

    Topics: ACTH Syndrome, Ectopic; Adrenal Insufficiency; Adrenalectomy; Adrenocorticotropic Hormone; Cushing S

2008
[Metopiron test].
    Nihon rinsho. Japanese journal of clinical medicine, 1997, Volume: 55 Suppl 2

    Topics: ACTH Syndrome, Ectopic; Adrenocorticotropic Hormone; Cushing Syndrome; Humans; Hypothalamo-Hypophyse

1997
[Metyrapone test].
    Nihon rinsho. Japanese journal of clinical medicine, 1997, Volume: 55 Suppl 2

    Topics: ACTH Syndrome, Ectopic; Adrenal Cortex Diseases; Adrenal Cortex Function Tests; Adrenal Insufficienc

1997
The diagnosis and differential diagnosis of Cushing's syndrome and pseudo-Cushing's states.
    Endocrine reviews, 1998, Volume: 19, Issue:5

    Topics: ACTH Syndrome, Ectopic; Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Circadian Rhythm; Cor

1998
Long-term medical treatment of ectopic ACTH syndrome.
    Southern medical journal, 1998, Volume: 91, Issue:11

    Topics: ACTH Syndrome, Ectopic; Adolescent; Adrenocortical Hyperfunction; Aminoglutethimide; Antineoplastic

1998

Trials

1 trial available for metyrapone and ACTH Syndrome, Ectopic

ArticleYear
Aminoglutethimide and metyrapone in the management of Cushing's syndrome.
    Acta endocrinologica, 1985, Volume: 109, Issue:4

    Topics: ACTH Syndrome, Ectopic; Adolescent; Adrenal Gland Neoplasms; Adult; Aminoglutethimide; Clinical Tria

1985

Other Studies

23 other studies available for metyrapone and ACTH Syndrome, Ectopic

ArticleYear
Ectopic ACTH-producing neuroendocrine tumor occurring with large recurrent metastatic pheochromocytoma: a case report.
    BMC endocrine disorders, 2022, Jul-19, Volume: 22, Issue:1

    Topics: ACTH Syndrome, Ectopic; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Aged, 80 and over; Cat

2022
Spontaneous adrenocorticotropic hormone (ACTH) normalisation due to tumour regression induced by metyrapone in a patient with ectopic ACTH syndrome: case report and literature review.
    BMC endocrine disorders, 2018, Mar-27, Volume: 18, Issue:1

    Topics: ACTH Syndrome, Ectopic; Adrenocorticotropic Hormone; Aged; Female; Humans; Hydrocortisone; Lung Neop

2018
Rapid control of severe neoplastic hypercortisolism with metyrapone and ketoconazole.
    European journal of endocrinology, 2015, Volume: 172, Issue:4

    Topics: ACTH Syndrome, Ectopic; Adrenal Gland Neoplasms; Adrenocortical Carcinoma; Adult; Aged; Cushing Synd

2015
Pneumocystis Pneumonia Concomitant with Ectopic ACTH Syndrome Caused by a Large Cell Neuroendocrine Carcinoma of the Thymus.
    Internal medicine (Tokyo, Japan), 2017, Volume: 56, Issue:5

    Topics: ACTH Syndrome, Ectopic; Adult; Bronchoalveolar Lavage; Carcinoma, Neuroendocrine; Early Diagnosis; E

2017
Clinical features and management of ectopic ACTH syndrome at a single institute in Japan.
    Endocrine journal, 2010, Volume: 57, Issue:12

    Topics: ACTH Syndrome, Ectopic; Adrenocorticotropic Hormone; Adult; Aged; Corticotropin-Releasing Hormone; D

2010
Metyrapone: a management option for ectopic ACTH syndrome in small cell lung cancer treated with intravenous etoposide.
    BMJ case reports, 2011, Aug-04, Volume: 2011

    Topics: ACTH Syndrome, Ectopic; Antineoplastic Agents, Phytogenic; Etoposide; Female; Humans; Infusions, Int

2011
Metyrapone for delirium due to Cushing's syndrome induced by occult ectopic adrenocorticotropic hormone secretion.
    The Journal of clinical psychiatry, 2004, Volume: 65, Issue:7

    Topics: ACTH Syndrome, Ectopic; Adrenocorticotropic Hormone; Cushing Syndrome; Delirium; Enzyme Inhibitors;

2004
Steroid-dependent ACTH-produced thymic carcinoid: regulation of POMC gene expression by cortisol via methylation of its promoter region.
    Hormone research, 2007, Volume: 67, Issue:5

    Topics: ACTH Syndrome, Ectopic; Adrenocorticotropic Hormone; Antimetabolites; Carcinoid Tumor; Child; DNA Me

2007
A case of dexamethasone non-suppressible Cushing's disease hardly differentiated from ectopic ACTH syndrome.
    Endocrinologia japonica, 1983, Volume: 30, Issue:1

    Topics: ACTH Syndrome, Ectopic; Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Dexamethasone; Diagnos

1983
[Successful conservative treatment of bronchial carcinoid with Cushing's syndrome due to ectopic ACTH production].
    Deutsche medizinische Wochenschrift (1946), 1983, Aug-05, Volume: 108, Issue:31-32

    Topics: ACTH Syndrome, Ectopic; Bronchial Neoplasms; Carcinoid Tumor; Cushing Syndrome; Cyclophosphamide; Do

1983
Human gamma-lipotropin radioimmunoassay: identification of immunoreactive gamma-lipotropin in human plasma and tissue.
    The Journal of clinical endocrinology and metabolism, 1981, Volume: 53, Issue:1

    Topics: ACTH Syndrome, Ectopic; Addison Disease; Adult; Antibody Specificity; beta-Lipotropin; Female; Human

1981
Glucocorticoid responsive ACTH secreting bronchial carcinoid tumours contain high concentrations of glucocorticoid receptors.
    Clinical endocrinology, 1994, Volume: 40, Issue:2

    Topics: ACTH Syndrome, Ectopic; Adolescent; Adult; Bronchial Neoplasms; Carcinoid Tumor; Corticotropin-Relea

1994
A comparison of the overnight and the standard metyrapone test for the differential diagnosis of adrenocorticotrophin-dependent Cushing's syndrome.
    Clinical endocrinology, 1996, Volume: 45, Issue:4

    Topics: ACTH Syndrome, Ectopic; Cortodoxone; Cushing Syndrome; Humans; Hydrocortisone; Metyrapone; Pilot Pro

1996
Metyrapone pre-treated inferior petrosal sinus sampling in the differential diagnosis of ACTH-dependent Cushing's syndrome.
    Clinical endocrinology, 1997, Volume: 46, Issue:5

    Topics: ACTH Syndrome, Ectopic; Adenoma; Adolescent; Adrenocorticotropic Hormone; Adult; Cortodoxone; Cushin

1997
Ectopic corticotroph adenoma in the cavernous sinus: case report.
    Neurosurgery, 1999, Volume: 45, Issue:4

    Topics: ACTH Syndrome, Ectopic; Cavernous Sinus; Death, Sudden; Dura Mater; Female; Humans; Magnetic Resonan

1999
Cost-effectiveness and accuracy of the tests used in the differential diagnosis of Cushing's syndrome.
    Pituitary, 1999, Volume: 1, Issue:2

    Topics: ACTH Syndrome, Ectopic; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adrenocorticotropi

1999
Short and long-term responses to metyrapone in the medical management of 91 patients with Cushing's syndrome.
    Clinical endocrinology, 1991, Volume: 35, Issue:2

    Topics: ACTH Syndrome, Ectopic; Adenoma; Adolescent; Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone;

1991
An evaluation of the distinction of ectopic and pituitary ACTH dependent Cushing's syndrome by clinical features, biochemical tests and radiological findings.
    The Quarterly journal of medicine, 1990, Volume: 77, Issue:283

    Topics: ACTH Syndrome, Ectopic; Adolescent; Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Dexamethas

1990
A new immunoradiometric assay for corticotropin evaluated in normal subjects and patients with Cushing's syndrome.
    Clinical chemistry, 1989, Volume: 35, Issue:4

    Topics: ACTH Syndrome, Ectopic; Adrenocorticotropic Hormone; Adult; Corticotropin-Releasing Hormone; Cosyntr

1989
Use of adrenal arterial embolization in severe ACTH-dependent Cushing's syndrome.
    Postgraduate medical journal, 1989, Volume: 65, Issue:766

    Topics: ACTH Syndrome, Ectopic; Adrenal Glands; Carcinoma; Combined Modality Therapy; Cushing Syndrome; Embo

1989
Ectopic ACTH syndrome caused by a bronchial carcinoid tumor responsive to dexamethasone, metyrapone, and corticotropin-releasing factor.
    The American journal of medicine, 1988, Volume: 84, Issue:4

    Topics: ACTH Syndrome, Ectopic; Adrenocorticotropic Hormone; Adult; Bronchial Neoplasms; Carcinoid Tumor; Co

1988
The corticotropin-releasing factor test in the diagnosis of ectopic ACTH secretion.
    The Western journal of medicine, 1987, Volume: 146, Issue:5

    Topics: ACTH Syndrome, Ectopic; Adenocarcinoma; Aged; Corticotropin-Releasing Hormone; Cushing Syndrome; Dex

1987
Cushing's syndrome secondary to ectopic corticotropin-releasing hormone-adrenocorticotropin secretion.
    The Journal of clinical endocrinology and metabolism, 1986, Volume: 63, Issue:3

    Topics: ACTH Syndrome, Ectopic; Bronchial Neoplasms; Carcinoid Tumor; Corticotropin-Releasing Hormone; Cushi

1986