metrizamide has been researched along with Morphine-Dependence* in 1 studies
1 other study(ies) available for metrizamide and Morphine-Dependence
| Article | Year |
|---|---|
Beta-endorphin suppression of acute morphine abstinence in morphine dependent monkeys: effective given intraventricularly but ineffective given intravenously.
Six female adult Macaca mulatta monkeys were made dependent upon morphine sulfate and were implanted with a chronic indwelling needle in the lateral ventricle of the brain for sterile intraventricular injections. Both beta-endorphin and morphine, in a dose dependent manner given intraventricularly suppressed the signs of 14 hour acute morphine abstinence. On a molar basis, beta-endorphin was more active than morphine in suppressing the signs of morphine abstinence. When given intravenously in much larger doses, beta-endorphin was ineffective in contrast to morphine which was effective in suppressing abstinence. Topics: Animals; beta-Endorphin; Brain; Cerebral Ventricles; Dose-Response Relationship, Drug; Endorphins; Female; Haplorhini; Injections, Intravenous; Injections, Intraventricular; Kinetics; Metrizamide; Morphine; Morphine Dependence; Time Factors | 1985 |