metrizamide and Meningeal-Neoplasms

The sensitivity of magnetic resonance imaging (MRI) to tissue alterations is particularly useful in spinal cord imaging. In addition to excellent anatomic display of this compact and complex area, syrinx cavities, tumors, and degenerating disks can be identified before they cause the anatomic distortion often necessary for detection by conventional means.

Topics: Astrocytoma; Bone Marrow Diseases; Brain Diseases; Ependymoma; Humans; Intervertebral Disc Displacement; Lipoma; Magnetic Resonance Spectroscopy; Meningeal Neoplasms; Metrizamide; Myelography; Neurofibroma; Spinal Cord; Spinal Cord Diseases; Spinal Cord Neoplasms; Spinal Diseases; Spinal Injuries; Spine; Syringomyelia; Tomography, X-Ray Computed

Topics: Brain Diseases; Brain Neoplasms; Cerebral Hemorrhage; Contrast Media; False Positive Reactions; Humans; Intracranial Arteriovenous Malformations; Ischemic Attack, Transient; Meningeal Neoplasms; Meningioma; Metrizamide; Tomography, X-Ray Computed

Topics: Ependymoma; Humans; Meningeal Neoplasms; Metrizamide; Myelography; Neurilemmoma; Spinal Cord Neoplasms; Tomography, X-Ray Computed

A distinct CT enhancement pattern of leptomeningeal metastasis from a systemic malignancy is described, corresponding to the pathologic and myelographic patterns of this entity. The uniform total subarachnoid enhancement, simulating intrathecal contrast, heralded sheetlike tumor proliferation along the surface of the spinal cord in an asymptomatic patient. Since the majority of hypervascular intraspinal abnormalities show focal enhancement with intravenous contrast, recognition of this pattern may provide unique clinical information.

Topics: Child, Preschool; Female; Humans; Kidney Neoplasms; Meningeal Neoplasms; Metrizamide; Sarcoma; Subarachnoid Space; Tomography, X-Ray Computed

Twenty patients suspected of meningeal carcinomatosis (MC) secondary to small cell carcinoma of the lung were evaluated by myelography and by cytologic examination of cerebrospinal fluid (CSF). In 4 patients both investigations demonstrated MC. Four had positive cytology but a negative myelogram. Five patients had a positive myelogram but negative cytology. Thus 13 of the 20 patients had MC diagnosed by one or both of these investigations. Two additional patients suspected of MC were studied; both had positive myelography, but cytologic examination of CSF was not performed in either case. Six patients underwent autopsy with microscopic examination of the spinal cord; in all cases post-mortem findings supported myelographic findings. In conclusion, myelography is useful in the evaluation of patients suspected of MC secondary to small carcinoma of the lung and complements the diagnostic role of CSF examination.

Topics: Carcinoma, Small Cell; Diagnosis, Differential; Humans; Lung Neoplasms; Meningeal Neoplasms; Metrizamide; Myelography

Computed tomography (CT) is currently the primary and generally the definitive imaging modality for the diagnosis, evaluation, and management of intracranial neoplasms in children. The value of CT in the postoperative period is discussed. The role of CT and myelography is stressed in the evaluation of cerebrospinal fluid seeding. CT is also important in demonstrating the iatrogenic disturbances of the central nervous system as a result of radiation and chemotherapy. The authors recommend that CT scans with and without contrast be obtained 2 weeks after surgery and before starting any form of adjuvant treatment. CT slices should be contiguous and 5-mm thick. Subsequent scans should be obtained every 3 to 4 months for the first year and every 6 months thereafter. Where necessary, CT scans after the introduction of intrathecal metrizamide may be necessary to evaluate the lower portion of the posterior fossa and brain stem.

Topics: Adolescent; Astrocytoma; Brain Neoplasms; Cerebral Ventricle Neoplasms; Child; Female; Glioma; Humans; Infant; Male; Meningeal Neoplasms; Meningioma; Metrizamide; Myelography; Neoplasm Seeding; Spinal Cord Neoplasms; Tomography, X-Ray Computed

Topics: Cervical Vertebrae; Foramen Magnum; Humans; Male; Meningeal Neoplasms; Metrizamide; Middle Aged; Myelography; Neurilemmoma; Spinal Neoplasms

Topics: Contrast Media; Ependymoma; Humans; Iopamidol; Iothalamic Acid; Meningeal Neoplasms; Meningioma; Metrizamide; Myelography; Spinal Cord Diseases; Spinal Cord Neoplasms; Spinal Diseases

The radiological manifestations of 16 pituitary adenomas, six meningiomas and 14 craniopharyngiomas were reviewed. The differential diagnosis of these tumors is possible with a few exceptions when skull radiography, CT, angiography and metrizamide cisternography are carefully evaluated. Prolonged injection angiography (PIA) is particularly important for demonstrating the contours of pituitary adenomas and meningiomas. Metrizamide cisternography is indicated when the tumor contours are obscure using PIA, or when the differential diagnosis is uncertain.

Topics: Adenoma; Cerebral Angiography; Cisterna Magna; Craniopharyngioma; Diagnosis, Differential; Humans; Meningeal Neoplasms; Meningioma; Metrizamide; Pituitary Neoplasms; Skull; Tomography, X-Ray Computed

Either EMT Head Scanner, CT 1010 (slice thickness 10mm) or EMI Body Scanner, CT 5005 (slice thickness 13mm) was used. The concentration of metrizamide was 170-250 mgI/microliter and the amount was 7-10 microliters. Either lumbar puncture or lateral C puncture was made.. 26 cases were included in this study. 1) disc disease: 11 cases, 2) spinal cord tumor: 6 cases, 3) Arnold-Chiari malformation: 3 cases, 4) atlantoaxial dislocation: 3 cases, 5) ossification of the posterior longitudinal ligament (associated with ossification of the ligamentum flavum): 2 cases (1 case), 6) spinal foreign body (acupuncture needle): 1 case.. 1) CT metrizamide myelography visualizes the subarachnoid space and makes it possible to know the lesion in the spinal canal in relation to the spinal cord in transverse plane. 2) It is difficult to determine the exact level of the lesion in axial plane. 3) The present technique does not allow to visualize the root sleeves. 4) It is difficult to delineate a compression of the subarachnoid space by small localized lesions (esp., disc diseases) due to overlapping the patent adjacent subarachnoid space within a slice 10 mm to 13 mm thick.

Topics: Astrocytoma; Humans; Meningeal Neoplasms; Meningioma; Metrizamide; Myelography; Neurilemmoma; Spinal Cord Neoplasms; Spinal Diseases; Tomography, X-Ray Computed

Topics: Astrocytoma; Humans; Lipoma; Meningeal Neoplasms; Meningioma; Metrizamide; Myelography; Neurilemmoma; Radiographic Image Enhancement; Spinal Cord Neoplasms; Tomography, X-Ray Computed

Twenty-three cases suspected of skull base tumors were examined by CT cisternography (CTC) with CT scanner (EMI 1010) from April, 1977 to March, 1978. The lesions in 20 cases were diagnosed as positive and confirmed by operation and/or autopsies. These include five acoustic neurinomas, six pituitary adenomas, two craniopharyngiomas, two skull base meningiomas, one arachnoid cyst and miscellaneous tumors. Isotonic Metrizamide solution four of 2-10 ml was injected via lumbar route. Patients were kept in 30 degrees Trendelenburg position for 60 minutes until the first scanning. Scannings were obtained 1, 3, 6, 24 and in some cases 48 hours after lumbar injection. No side effects except for headache, nausea, vomiting occurred. There were no convulsions. In diagnosing cerebellopontine angle tumors, the indirect signs such as asymmetrical ambient cisterns are of importance, when combined with direct signs, i.e. a shadow defect. Parasellar tumors are usually difficult to diagnose with conventional CT due to streak artifact caused by adjacent bony structure. In CTC the extrasellar extension of pituitary tumors were clearly visible. The size, shape, dimensions and the relationship to the adjacent structures of the craniopharyngiomas were easily demonstrated with CTC especially when a coronal view was added. In arachnoid cyst, CTC demonstrated the delayed turnover of Metrizamide between the cyst cavity and the adjacent subarachnoid space. In conclusion, CTC is an useful neuroradiological diagnostic adjunct because of minimal bony streak artifact and high spatial resolution. It would be expected that small tumors of even 2-3 mm in diameter might be diagnosed, from the fact that the middle cerebral artery in the suprasellar cistern is clearly visible as a shadow defect.

Topics: Brain Neoplasms; Child; Cisterna Magna; Craniopharyngioma; Female; Humans; Meningeal Neoplasms; Meningioma; Metrizamide; Middle Aged; Neuroma, Acoustic; Tomography, X-Ray Computed

Metrizamide, a nonionic, water-soluble contrast agent, was injected into the ventricular system of 3 patients with indwelling ventricular catheters and subcutaneous cerebrospinal fluid reservoirs. A first-order rate constant, k, for metrizamide washout from the right lateral ventricle was determined with reference to mean ventricular metrizamide concentration on serial CAT scans; right ventricular volume, V, was estimated after metrizamide injection by multiplying the appropriate ventricular area on consecutive CAT slices by the nominal slice thickness. The rate of right lateral ventricular CSF formation, If, in our 3 patients was calculated as k X V and ranged from 0.083 to 0.103 ml per minute.

Topics: Adult; Aged; Carcinoma; Cerebral Ventricle Neoplasms; Cerebral Ventriculography; Cerebrospinal Fluid; Cerebrospinal Fluid Shunts; Female; Humans; Hydrocephalus; Injections, Intraventricular; Male; Meningeal Neoplasms; Metrizamide; Neoplasm Metastasis; Tomography, X-Ray Computed

The technique and results of cerebello-pontine angle cisternography with metrizamide (Amipaque) in 34 patients are reported. Fourteen tumors were diagnosed. The internal auditory canal was normal in 19 patients, and in all of them the facial and statoacoustic nerves were visible. One examination was unsuccessful. No serious complications occurred. Headache was recorded in 76 per cent and transient EEG disturbance in 32 per cent of the patients.

Topics: Adult; Aged; Cerebellar Neoplasms; Cerebellopontine Angle; Cholesteatoma; Female; Humans; Male; Meningeal Neoplasms; Meningioma; Metrizamide; Middle Aged; Myelography; Neuroma, Acoustic