metrizamide and Lymphoma

Metrizamide has been used for examination of the gastrointestinal tract and tracheobronchial tree of infants. Contrast agents may enter the lungs during such examinations. The current study was undertaken to determine whether there would be any later pulmonary effects when metrizamide was administered to the lungs of weanling mice.. One hundred fifty mice (18-21 days old), divided into groups, received either 75 microL of metrizamide, using the manufacturer's diluent (190 mg iodine [I]/mL), or saline solution administered to the lungs by injection into the trachea. The mice were observed for the duration of their lives. Moribund animals were killed. At death, all animals underwent necropsy. The lungs were fixed in formalin, and histologic sections were examined for pathologic changes.. The incidence of lung tumors was increased (P less than .05) in the lungs of mice receiving metrizamide compared with those receiving saline. Eighteen percent of the lung tumors in the metrizamide-treated mice were lymphomas, a histologic type not found in the saline-treated controls.. A hypothesis proposing that metrizamide may be an initiator of carcinogenic transformation rather than a carcinogen was developed.

Topics: Adenocarcinoma; Animals; Bronchi; Female; Lung Neoplasms; Lymphoma; Metrizamide; Mice; Mice, Inbred ICR

Large unilamellar phospholipid vesicles were prepared and loaded with various radiographic contrast media. Body CT following in vivo administration of these vesicles in the rat demonstrated opacification of organs associated with the reticuloendothelial system. Image enhancement in the spleen and liver was dose dependent and was linearly related within the dose range investigated. Contrast enhancement was observed within five minutes of intravenous administration, was maximal 60 minutes after injection, and declined during the second hour. Clearance of the radiographic contrast material was complete within 24 hours. Diffuse splenic lymphoma following intraperitoneal or intrasplenic injection of lymphoma cells, and solitary lymphoma nodules following intrahepatic injection were readily detected as nonenhanced areas following injection of liposomes.

Topics: Animals; Contrast Media; Diatrizoate; Diatrizoate Meglumine; Drug Combinations; Iothalamate Meglumine; Liposomes; Lymphoma; Male; Metrizamide; Radiographic Image Enhancement; Rats; Rats, Inbred Lew; Rats, Inbred Strains; Tomography, X-Ray Computed; Triiodobenzoic Acids

Topics: Adolescent; Adult; Arachnoiditis; Child, Preschool; Female; Humans; Lymphoma; Male; Metrizamide; Middle Aged; Myelography; Neurilemmoma; Solubility; Spinal Cord Neoplasms; Water