metrizamide and Kidney-Tubular-Necrosis--Acute

Forty-seven dogs or seventy-four kidneys, respectively, were used in studies into the activity of metrizamide (Amipaque). The angiograms were of good quality; as compared with contrast media tested before, the incidence of abnormalities was somewhat lower, and the symptoms (spasm, inhomogeneous nephrogram) were less important. Histological examination showed that plenty of homogeneous pink proteinlike substance had accumulated in many tubules as well as in the lumen of the Bowman's capsules; fibroses were seen in several parts after 7 and 28 days, respectively. However, the evaluation of the renal function showed no considerable changes in the laboratory values.

Topics: Angiography; Animals; Dogs; Female; Kidney; Kidney Tubular Necrosis, Acute; Male; Metrizamide; Pyelonephritis; Renal Artery