metrizamide and Hemiplegia

The complications of cerebral angiography have been carefully recorded in 308 patients referred for cerebral angiography during one year, 1977--1978. The patients were randomly sampled for metrizamide or meglumine metrizoate as contrast medium according to a code list, and the two contrast media were compared using a double blind technique. The frequency of complications was the same for metrizamide and meglumine metrizoate. Metrizamide had the advantage that it caused no discomfort in selective external carotid angiography, while this was a problem with meglumine metrizoate. The study seemed to indicate that factors other than toxicity of the contrast medium are of major importance to explain the complications of cerebral angiography.

Topics: Adolescent; Adult; Aged; Cerebral Angiography; Child; Child, Preschool; Double-Blind Method; Electrocardiography; Electroencephalography; Electromyography; Female; Hemiplegia; Humans; Infant; Infant, Newborn; Male; Meglumine; Metrizamide; Middle Aged; Sorbitol; Unconsciousness; Vision Disorders

The adverse effects of cerebral angiography with metrizamide and meglumine metrizoate were compared in 20 patients for each contrast medium using a double blind technic. Deterioration of the EEG and bradycardial reactions were seen more often with meglumine metrizoate than with metrizamide and these differences were statistically significant. Metrizamide also had a shorter circulation time, less influence on the blood pressure and EMG than meglumine metrizoate, but these differences were not statistically significant. The clinical examinations showed no difference in the minor adverse effects. One patient had transient hemiparesis and dysarthria after angiography with meglumine metrizoate but no serious complications were seen in the others.

Topics: Adolescent; Adult; Blood Pressure; Bradycardia; Cerebral Angiography; Clinical Trials as Topic; Contrast Media; Electroencephalography; Female; Fever; Headache; Hemiplegia; Humans; Iodobenzoates; Male; Metrizamide; Metrizoic Acid; Middle Aged; Muscles; Speech Disorders

The case is presented of a patient showing multiple subcortical haemorrhages after lumbar metrizamide myelography. This complication after intrathecally administered metrizamide contrast medium appears not to have been reported before. Several different possible explanations are proposed for the phenomena observed in this case.

Topics: Back Pain; Cerebral Hemorrhage; Electroencephalography; Epilepsy; Hemiplegia; Humans; Lumbosacral Region; Male; Metrizamide; Middle Aged; Myelography; Tomography, X-Ray Computed

A case of neurologic sequelae from intrathecal metrizamide is presented. The patient had a convulsion, became comatose, and transiently developed mutism and hemiparesis, with eventual full recovery. Metrizamide is generally safe, but side effects do occur, and they may require clinical attention and follow-up.

Topics: Adult; Coma; Conversion Disorder; Diagnosis, Differential; Female; Hemiplegia; Humans; Metrizamide; Mutism; Myelography; Seizures

We report a case of aphasia and right hemiplegia, developing after myelography with metrizamide and lasting for an unusually long time. The neurological disorders, manifested 1 h after the examination was completed, were due to accidental passage of contrast medium into the basal cisterns. In the light of analogous case reports in the literature, as well as experimental data concerning the biochemical activity of metrizamide, possible aetiopathogenetic mechanisms responsible for such disturbances are indicated. The authors underline the lack of effective therapeutic measures after the onset of the disorders, and thus the importance of preventing such complications that behave functionally as true ictuses although with no anatomic substratum.

Topics: Aphasia; Hemiplegia; Humans; Male; Metrizamide; Middle Aged; Myelography; Time Factors

Topics: Adult; Aged; Cervical Vertebrae; Coma; Confusion; Epilepsy, Tonic-Clonic; Female; Hemiplegia; Humans; Intervertebral Disc Displacement; Male; Metrizamide; Middle Aged; Myelography; Spinal Cord Diseases; Spinal Diseases