metrizamide and Body-Weight

The cardiotoxic effect of Isopaque Coronar (metrizoate 370 mg I/ml) and Amipaque (metrizamide 370 mg I/ml) was analysed in 52 infants weighing less than 5 kg. In each group of patients 37 injections of contrast medium were performed and the immediate side effects, extrasystoles and change in heart frequency, were recorded. Amipaque caused significantly less bradycardia and significantly fewer immediate extrasystoles than Isopaque Coronar. The results indicate a lower cardiotoxicity of Amipaque in cardioangiography in infants.

Topics: Angiocardiography; Body Weight; Cardiac Catheterization; Cardiac Complexes, Premature; Heart Rate; Humans; Infant; Infant, Newborn; Iodobenzoates; Metrizamide; Metrizoic Acid

We conducted a prospective study to examine the effect of pentobarbital administration on the development of seizures in dogs that had undergone cervical myelography with metrizamide while anesthetized with halothane. Thirty dogs scheduled for cervical myelography were assigned to 3 groups. Dogs in group 1 received no pentobarbital. Those in group 2 were administered pentobarbital (5 mg/kg, IM) before induction of anesthesia, and those in group 3 received pentobarbital at the end of the procedure when the anesthetic vaporizer was turned off. Anesthesia was induced with thiamylal sodium in all dogs and was maintained with halothane. Dogs that underwent surgery immediately after the myelography were not included in the study. A significant difference was not found among the 3 groups in terms of number of dogs that had seizures, mean body weight of the dogs, duration of anesthesia after injection of metrizamide, time from extubation to first seizure, volume of metrizamide injected, or clinician performing the myelography.

Topics: Anesthesia, General; Animals; Body Weight; Dog Diseases; Dogs; Halothane; Metrizamide; Myelography; Pentobarbital; Premedication; Prospective Studies; Seizures

Monomeric ionic contrast media are known to induce a significant degree of pulmonary edema following intravenous injection of high doses of contrast media in rats. This edema has been shown to be dependent on dose and rate of injection. Metrizamide administered at the same dose causes much less and more transient pulmonary edema than diatrizoate. Although blood osmolalities were significantly and consistently lower following administration of metrizamide compared with diatrizoate, this difference alone does not account for the difference in the degree of pulmonary edema induced by these media.

Topics: Animals; Body Weight; Diatrizoate; Diatrizoate Meglumine; Lung; Male; Metrizamide; Organ Size; Osmolar Concentration; Pulmonary Edema; Rats; Rats, Inbred Strains; Time Factors