metrizamide and Albuminuria

The degree of albuminuria induced by nephroangiography was compared following injection of the ionic contrast medium Isopaque Cerebral (meglumine-ca-metrizoate) and the non-ionic Amipaque (metrizamide) in man. Both induced albuminuria in high frequency but the degree did not differ significantly.

Topics: Adult; Aged; Albuminuria; Female; Humans; Iodobenzoates; Male; Metrizamide; Metrizoic Acid; Middle Aged; Radiography; Renal Artery

The degree of albuminuria induced by renal arteriography with the monoacid dimeric contrast medium ioxaglate was studied in 19 patients. Ioxaglate did not cause significant changes in urinary albumin concentrations (median concentration after angiography = 0.022 g/g creatinine). The results with ioxaglate are compared with those of an identically designed study performed earlier with the contrast media metrizoate and metrizamide, in which both caused significantly increased concentrations of urinary albumin (1.1 g/g creatinine and 0.96 g/g creatinine, respectively). The degree of pain/heat sensation following semiselective renal arteriography with metrizoate and ioxaglate was also compared using a visual analog scale in 34 patients. Ioxaglate caused no pain and a significantly lower heat sensation than metrizoate.

Topics: Adult; Aged; Albuminuria; Angiography; Contrast Media; Hot Temperature; Humans; Iodobenzoates; Ioxaglic Acid; Kidney; Metrizamide; Metrizoic Acid; Middle Aged; Pain; Thermosensing; Triiodobenzoic Acids

The proteinuria following aortography and selective nephroangiography in 60 patients using Isopaque Cerebral, Urografin 60% and Amipaque was investigated. The results indicate an increase in glomerular permeability and possibly an overload of tubular reabsorptive capacity after angiography. The changes are transient. No permanent injury to the kidney appears to occur.

Topics: Albuminuria; beta 2-Microglobulin; Contrast Media; Diatrizoate Meglumine; Female; Humans; Immunoglobulin G; Male; Metrizamide; Metrizoic Acid; Proteinuria; Radiography; Renal Artery

The influence on albuminuria following nephroangiography was investigated after addition of Ca2+ to the non-ionic contrast medium metrizamide (Amipaque) in the rat and after addition of Ca2+ or Ca2+ and Mg2+ to the experimental non-ionic contrast medium C 29 in the dog. When Ca2+ or CA2+ and Mg2+ were added to metrizamide or C29 in concentrations two to three times th plasma level no influence occurred. Higher concentrations of Ca2+ (10-25 mmol/l) in the metrizamide or C29 solutions resulted in increased albuminuria.

Topics: Albuminuria; Animals; Blood-Brain Barrier; Calcium; Contrast Media; Dogs; Iopamidol; Iothalamic Acid; Magnesium; Metrizamide; Radiography; Rats; Renal Artery

The degree of albuminuria following hephroangiography with the ionic contrast medium Urografin, the non-ionic Amipaque and a recently synthesized non-ionic contrast medium with the code name C 29 was compared. Significantly less albuminuria was caused by C 29 than by the other two contrast media.

Topics: Albuminuria; Animals; Contrast Media; Diatrizoate; Dogs; Metrizamide; Radiography; Renal Artery