metribolone and Hypercholesterolemia

metribolone has been researched along with Hypercholesterolemia* in 1 studies

Other Studies

1 other study(ies) available for metribolone and Hypercholesterolemia

Article	Year
2-Chloro-4-[[(1R,2R)-2-hydroxy-2-methyl-cyclopentyl]amino]-3-methyl-benzonitrile: A Transdermal Selective Androgen Receptor Modulator (SARM) for Muscle Atrophy. Journal of medicinal chemistry, 2016, Jan-28, Volume: 59, Issue:2 A transdermal SARM has a potential to have therapeutic benefit through anabolic activity in muscle while sparing undesired effects of benign prostate hyperplasia (BPH) and liver-mediated decrease in HDL-C. 2-Chloro-4-[(2-hydroxy-2-methyl-cyclopentyl)amino]-3-methyl-benzonitrile 6 showed the desired muscle and prostate effects in a preclinical ORX rat model. Compound 6 had minimal effect on HDL-C levels in cynomolgus monkeys and showed human cadaver skin permeability, thus making it an effective tool for proof-of-concept studies in a clinical setting. Topics: Administration, Cutaneous; Anabolic Agents; Androgen Antagonists; Aniline Compounds; Animals; Cholesterol, HDL; Humans; Hypercholesterolemia; In Vitro Techniques; Liver; Macaca fascicularis; Male; Models, Molecular; Muscular Atrophy; Nitriles; Orchiectomy; Prostatic Hyperplasia; Rats; Skin Absorption; Structure-Activity Relationship	2016

Article

Year

2-Chloro-4-[[(1R,2R)-2-hydroxy-2-methyl-cyclopentyl]amino]-3-methyl-benzonitrile: A Transdermal Selective Androgen Receptor Modulator (SARM) for Muscle Atrophy.

Journal of medicinal chemistry, 2016, Jan-28, Volume: 59, Issue:2

A transdermal SARM has a potential to have therapeutic benefit through anabolic activity in muscle while sparing undesired effects of benign prostate hyperplasia (BPH) and liver-mediated decrease in HDL-C. 2-Chloro-4-[(2-hydroxy-2-methyl-cyclopentyl)amino]-3-methyl-benzonitrile 6 showed the desired muscle and prostate effects in a preclinical ORX rat model. Compound 6 had minimal effect on HDL-C levels in cynomolgus monkeys and showed human cadaver skin permeability, thus making it an effective tool for proof-of-concept studies in a clinical setting.

Topics: Administration, Cutaneous; Anabolic Agents; Androgen Antagonists; Aniline Compounds; Animals; Cholesterol, HDL; Humans; Hypercholesterolemia; In Vitro Techniques; Liver; Macaca fascicularis; Male; Models, Molecular; Muscular Atrophy; Nitriles; Orchiectomy; Prostatic Hyperplasia; Rats; Skin Absorption; Structure-Activity Relationship

2016