metoprolol has been researched along with Stroke in 24 studies
Metoprolol: A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
metoprolol : A propanolamine that is 1-(propan-2-ylamino)propan-2-ol substituted by a 4-(2-methoxyethyl)phenoxy group at position 1.
Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We explored whether vascular protection by carvedilol could contribute to its superior effects in the treatment of heart failure (HF) compared with metoprolol tartrate in the COMET (Carvedilol Or Metoprolol European Trial) study." | 9.12 | Carvedilol protects better against vascular events than metoprolol in heart failure: results from COMET. ( Cleland, JG; Di Lenarda, A; Komajda, M; Lukas, MA; Metra, M; Moullet, C; Poole-Wilson, PA; Remme, WJ; Scherhag, A; Spark, P; Swedberg, K; Torp-Pedersen, C, 2007) |
| "Routine use of preoperative metoprolol, but not atenolol, is associated with stroke after noncardiac surgery, even after adjusting for comorbidities." | 7.79 | Perioperative metoprolol and risk of stroke after noncardiac surgery. ( Freundlich, RE; Kheterpal, S; Mashour, GA; Matlen, L; Merte, J; Nallamothu, BK; Shanks, A; Sharifpour, M; Tremper, KK; Vlisides, PE; Weightman, A, 2013) |
| "The use of metoprolol and atenolol is associated with increased risks of postoperative stroke, compared with bisoprolol." | 7.79 | Selective β1-antagonism with bisoprolol is associated with fewer postoperative strokes than atenolol or metoprolol: a single-center cohort study of 44,092 consecutive patients. ( Ashes, C; Beattie, WS; Hare, GM; Judelman, S; Mazer, CD; Tait, G; Wijeysundera, DN, 2013) |
| "The clinical data of 24 patients with ischemic stroke in our intensive care unit were analyzed, and received amlodipine or metoprolol for more than 14 days with 24-hour ambulatory blood pressure monitoring." | 5.19 | Effects of different antihypertensive drugs on blood pressure variability in patients with ischemic stroke. ( Hu, WL; Ji, M; Li, SJ, 2014) |
| "We explored whether vascular protection by carvedilol could contribute to its superior effects in the treatment of heart failure (HF) compared with metoprolol tartrate in the COMET (Carvedilol Or Metoprolol European Trial) study." | 5.12 | Carvedilol protects better against vascular events than metoprolol in heart failure: results from COMET. ( Cleland, JG; Di Lenarda, A; Komajda, M; Lukas, MA; Metra, M; Moullet, C; Poole-Wilson, PA; Remme, WJ; Scherhag, A; Spark, P; Swedberg, K; Torp-Pedersen, C, 2007) |
| "Rats were subjected to middle cerebral artery occlusion-reperfusion to evaluate the effect on stroke of the selective β1AR blocker metoprolol (12." | 4.31 | Neutrophil β ( Benito, JM; Calle, D; Carneado-Ruíz, J; Castejón, R; Clemente-Moragón, A; Cortés-Canteli, M; Cussó, L; Desco, M; Fernández-Ferro, JC; Fuster, V; Gómez, M; Ibáñez, B; Moro, MA; Oliver, E; Pradillo, JM; Rallón, N; Sánchez-González, J, 2023) |
| " Finally, animals were treated with metoprolol to evaluate a pharmacologic treatment option to prevent the development of heart failure." | 3.85 | Stroke-induced chronic systolic dysfunction driven by sympathetic overactivity. ( Bieber, M; Frantz, S; Heuschmann, PU; Higuchi, T; Hofmann, U; Kleinschnitz, C; Kraft, P; Ritter, O; Schuh, K; Tanai, E; Werner, RA, 2017) |
| "Routine use of preoperative metoprolol, but not atenolol, is associated with stroke after noncardiac surgery, even after adjusting for comorbidities." | 3.79 | Perioperative metoprolol and risk of stroke after noncardiac surgery. ( Freundlich, RE; Kheterpal, S; Mashour, GA; Matlen, L; Merte, J; Nallamothu, BK; Shanks, A; Sharifpour, M; Tremper, KK; Vlisides, PE; Weightman, A, 2013) |
| "The use of metoprolol and atenolol is associated with increased risks of postoperative stroke, compared with bisoprolol." | 3.79 | Selective β1-antagonism with bisoprolol is associated with fewer postoperative strokes than atenolol or metoprolol: a single-center cohort study of 44,092 consecutive patients. ( Ashes, C; Beattie, WS; Hare, GM; Judelman, S; Mazer, CD; Tait, G; Wijeysundera, DN, 2013) |
| "Asymptomatic carotid stenosis is when this narrowing occurs in people without a history or symptoms of this disease." | 3.01 | Pharmacological interventions for asymptomatic carotid stenosis. ( Cassola, N; Clezar, CN; Flumignan, CD; Flumignan, RL; Nakano, LC; Trevisani, VF, 2023) |
| "IV metoprolol was the only IV BB that reduced mortality [aRR (95% CI): 0." | 1.72 | The Effect of Intravenous and Oral Beta-Blocker Use in Patients with Type B Thoracic Aortic Dissection. ( Malas, MB; Mathlouthi, A; Naazie, I; Nejim, B, 2022) |
| "Mortality, pulmonary edema, and need for IABP were reduced by >50% (p < 0." | 1.32 | Impact of prophylactic postoperative beta-blockade on post-cardiothoracic surgery length of stay and atrial fibrillation. ( Coleman, CI; Gallagher, R; Gillespie, EL; Horowitz, S; Kluger, J; Perkerson, KA; White, CM, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (41.67) | 29.6817 |
| 2010's | 11 (45.83) | 24.3611 |
| 2020's | 3 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Nejim, B | 1 |
| Mathlouthi, A | 1 |
| Naazie, I | 1 |
| Malas, MB | 1 |
| Clemente-Moragón, A | 1 |
| Oliver, E | 1 |
| Calle, D | 1 |
| Cussó, L | 1 |
| Gómez, M | 1 |
| Pradillo, JM | 1 |
| Castejón, R | 1 |
| Rallón, N | 1 |
| Benito, JM | 1 |
| Fernández-Ferro, JC | 1 |
| Carneado-Ruíz, J | 1 |
| Moro, MA | 1 |
| Sánchez-González, J | 1 |
| Fuster, V | 1 |
| Cortés-Canteli, M | 1 |
| Desco, M | 1 |
| Ibáñez, B | 1 |
| Clezar, CN | 1 |
| Flumignan, CD | 1 |
| Cassola, N | 1 |
| Nakano, LC | 1 |
| Trevisani, VF | 1 |
| Flumignan, RL | 1 |
| Zhang, Y | 1 |
| Sun, N | 1 |
| Jiang, X | 1 |
| Xi, Y | 1 |
| Bieber, M | 1 |
| Werner, RA | 1 |
| Tanai, E | 1 |
| Hofmann, U | 1 |
| Higuchi, T | 1 |
| Schuh, K | 1 |
| Heuschmann, PU | 1 |
| Frantz, S | 1 |
| Ritter, O | 1 |
| Kraft, P | 1 |
| Kleinschnitz, C | 1 |
| Jacka, MJ | 1 |
| Guyatt, G | 1 |
| Mizera, R | 1 |
| Van Vlymen, J | 1 |
| Ponce de Leon, D | 1 |
| Schricker, T | 1 |
| Bahari, MY | 1 |
| Lv, B | 1 |
| Afzal, L | 1 |
| Plou García, MP | 1 |
| Wu, X | 1 |
| Nigro Maia, L | 1 |
| Arrieta, M | 1 |
| Rao-Melacini, P | 1 |
| Devereaux, PJ | 1 |
| Mashour, GA | 1 |
| Sharifpour, M | 1 |
| Freundlich, RE | 1 |
| Tremper, KK | 1 |
| Shanks, A | 1 |
| Nallamothu, BK | 1 |
| Vlisides, PE | 1 |
| Weightman, A | 1 |
| Matlen, L | 1 |
| Merte, J | 1 |
| Kheterpal, S | 1 |
| Ashes, C | 2 |
| Judelman, S | 2 |
| Wijeysundera, DN | 1 |
| Tait, G | 3 |
| Mazer, CD | 3 |
| Hare, GM | 3 |
| Beattie, WS | 3 |
| Eisenach, JC | 1 |
| Wicker, JF | 1 |
| Bronheim, D | 1 |
| Wijeysundera, D | 1 |
| Ji, M | 1 |
| Li, SJ | 1 |
| Hu, WL | 1 |
| DiNicolantonio, JJ | 1 |
| Fuchs, FD | 1 |
| O'Keefe, JH | 1 |
| Caramelli, B | 2 |
| Gualandro, DM | 2 |
| Freitas, S | 1 |
| Yu, PC | 2 |
| Calderaro, D | 2 |
| Rolfo, F | 1 |
| Bobbio, M | 1 |
| Angeli, F | 1 |
| Cavallini, C | 1 |
| Priebe, HJ | 1 |
| Alonso-Coello, P | 1 |
| Alvarez, C | 1 |
| Cruz, P | 1 |
| Torán, L | 1 |
| De Nadal, M | 1 |
| Martínez, M | 1 |
| Paniagua, P | 1 |
| Mases, A | 1 |
| Urrutia, G | 1 |
| Ragoonanan, TE | 1 |
| Tsui, AK | 1 |
| Leong-Poi, H | 1 |
| Wilson, DF | 1 |
| Yu, J | 1 |
| Liu, E | 1 |
| Noronha, M | 1 |
| Dattani, ND | 1 |
| Mitsakakis, N | 1 |
| Marques, AC | 1 |
| Tchan, M | 1 |
| Sillence, D | 1 |
| Coleman, CI | 1 |
| Perkerson, KA | 1 |
| Gillespie, EL | 1 |
| Kluger, J | 1 |
| Gallagher, R | 1 |
| Horowitz, S | 1 |
| White, CM | 1 |
| Remme, WJ | 1 |
| Torp-Pedersen, C | 1 |
| Cleland, JG | 1 |
| Poole-Wilson, PA | 1 |
| Metra, M | 1 |
| Komajda, M | 1 |
| Swedberg, K | 1 |
| Di Lenarda, A | 1 |
| Spark, P | 1 |
| Scherhag, A | 1 |
| Moullet, C | 1 |
| Lukas, MA | 1 |
| Intengan, HD | 1 |
| Schiffrin, EL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Controlled Trial of Influenza Vaccine to Prevent Adverse Vascular Events: A Pilot Study[NCT01945268] | Phase 4 | 107 participants (Actual) | Interventional | 2015-04-30 | Completed | ||
| A Randomized Controlled Trial of Influenza Vaccine to Prevent Adverse Vascular Events[NCT02762851] | Phase 4 | 5,000 participants (Anticipated) | Interventional | 2016-06-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for metoprolol and Stroke
| Article | Year |
|---|---|
Pharmacological interventions for asymptomatic carotid stenosis.
Topics: Aspirin; Atherosclerosis; Atorvastatin; Carotid Stenosis; Chlorthalidone; Fluvastatin; Hemorrhage; H | 2023 |
Comparative efficacy of β-blockers on mortality and cardiovascular outcomes in patients with hypertension: a systematic review and network meta-analysis.
Topics: Adrenergic beta-Antagonists; Age Factors; Antihypertensive Agents; Atenolol; Coronary Disease; Human | 2017 |
[The POISE study].
Topics: Adrenergic beta-Antagonists; Bradycardia; Delayed-Action Preparations; Heart Arrest; Humans; Hyperte | 2008 |
Influence of beta-blockers on the outcome of at risk patients.
Topics: Adrenergic beta-Antagonists; Cohort Studies; Contraindications; Coronary Disease; Double-Blind Metho | 2009 |
2 trials available for metoprolol and Stroke
| Article | Year |
|---|---|
Effects of different antihypertensive drugs on blood pressure variability in patients with ischemic stroke.
Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Amlodipine; Antihypertensive Agents; Blood Pre | 2014 |
Carvedilol protects better against vascular events than metoprolol in heart failure: results from COMET.
Topics: Adrenergic beta-Antagonists; Angina, Unstable; Carbazoles; Carvedilol; Death, Sudden, Cardiac; Doubl | 2007 |
Carvedilol protects better against vascular events than metoprolol in heart failure: results from COMET.
Topics: Adrenergic beta-Antagonists; Angina, Unstable; Carbazoles; Carvedilol; Death, Sudden, Cardiac; Doubl | 2007 |
Carvedilol protects better against vascular events than metoprolol in heart failure: results from COMET.
Topics: Adrenergic beta-Antagonists; Angina, Unstable; Carbazoles; Carvedilol; Death, Sudden, Cardiac; Doubl | 2007 |
Carvedilol protects better against vascular events than metoprolol in heart failure: results from COMET.
Topics: Adrenergic beta-Antagonists; Angina, Unstable; Carbazoles; Carvedilol; Death, Sudden, Cardiac; Doubl | 2007 |
18 other studies available for metoprolol and Stroke
| Article | Year |
|---|---|
The Effect of Intravenous and Oral Beta-Blocker Use in Patients with Type B Thoracic Aortic Dissection.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Aortic Aneurysm, Thoracic; Aortic Dissection; Dat | 2022 |
Neutrophil β
Topics: Animals; Brain Ischemia; Ischemic Stroke; Metoprolol; Neuroinflammatory Diseases; Neutrophils; Rats; | 2023 |
Stroke-induced chronic systolic dysfunction driven by sympathetic overactivity.
Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Brain Ischemia; Echocardiography; Epinephrine; Hear | 2017 |
Age Does Not Affect Metoprolol's Effect on Perioperative Outcomes (From the POISE Database).
Topics: Adrenergic beta-1 Receptor Antagonists; Age Factors; Aged; Aged, 80 and over; Databases, Factual; Fe | 2018 |
Perioperative metoprolol and risk of stroke after noncardiac surgery.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Analysis of Variance; Ateno | 2013 |
Selective β1-antagonism with bisoprolol is associated with fewer postoperative strokes than atenolol or metoprolol: a single-center cohort study of 44,092 consecutive patients.
Topics: Adrenergic beta-1 Receptor Antagonists; Aged; Atenolol; Bisoprolol; Cohort Studies; Female; Humans; | 2013 |
Patient safety: anesthesiology contributions and supplements to the American Society of Anesthesiologists' Annual Meeting.
Topics: Adrenergic beta-1 Receptor Antagonists; Atenolol; Bisoprolol; Female; Humans; Male; Metoprolol; Post | 2013 |
Does β selectivity really affect outcome?
Topics: Adrenergic beta-1 Receptor Antagonists; Atenolol; Bisoprolol; Female; Humans; Male; Metoprolol; Post | 2014 |
In reply.
Topics: Adrenergic beta-1 Receptor Antagonists; Atenolol; Bisoprolol; Female; Humans; Male; Metoprolol; Post | 2014 |
It takes the right medications to prevent a million heart attacks and strokes.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Atenolol; Health Promoti | 2014 |
Beta-blocker therapy in non-cardiac surgery.
Topics: Adrenergic beta-Antagonists; Bradycardia; Cardiovascular Diseases; Causality; Comorbidity; Humans; H | 2008 |
[Beta-blockers in patients undergoing noncardiac surgery: implications of the POISE study].
Topics: Adrenergic beta-Antagonists; Bradycardia; Contraindications; Female; Forecasting; Heart; Heart Arres | 2009 |
Metoprolol reduces cerebral tissue oxygen tension after acute hemodilution in rats.
Topics: Adrenergic beta-Antagonists; Angiotensin II; Animals; Brain; Cardiac Output; Catecholamines; Cerebro | 2009 |
Beta-blockers and non-cardiac operations what will change after the POISE study?: ?qué cambia después del estudio POISE?
Topics: Adrenergic beta-Antagonists; Humans; Metoprolol; Myocardial Infarction; Perioperative Care; Randomiz | 2009 |
Fabry disease and Factor V Leiden: a potent vascular risk combination.
Topics: Activated Protein C Resistance; alpha-Galactosidase; Aspirin; Atorvastatin; Coronary Stenosis; Defib | 2011 |
[Brazilian consensus for the thrombolysis in acute ischemic stroke].
Topics: Acute Disease; Brain Ischemia; Brazil; Enalapril; Fibrinolytic Agents; Humans; Metoprolol; Stroke; T | 2002 |
Impact of prophylactic postoperative beta-blockade on post-cardiothoracic surgery length of stay and atrial fibrillation.
Topics: Adrenergic beta-Antagonists; Aged; Atenolol; Atrial Fibrillation; Cardiac Surgical Procedures; Cohor | 2004 |
Disparate effects of carvedilol versus metoprolol treatment of stroke-prone spontaneously hypertensive rats on endothelial function of resistance arteries.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Carbazoles; Carvedilol; Endothelium, | 2000 |