metoprolol has been researched along with Muscle Contraction in 31 studies
Metoprolol: A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
metoprolol : A propanolamine that is 1-(propan-2-ylamino)propan-2-ol substituted by a 4-(2-methoxyethyl)phenoxy group at position 1.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Eight asthmatic patients were investigated in a double-blind cross-over study after oral administration of 100 mg atenolol, 10 mg metoprolol and placebo." | 9.05 | Cardioselectivity of atenolol and metoprolol. A study in asthmatic patients. ( Löfdahl, CG; Svedmyr, N, 1981) |
| " In 21 subjects with stage 1 hypertension, we measured muscle oxygenation and forearm blood flow responses to reflex increases in sympathetic nerve activity evoked by lower body negative pressure at rest, and during rhythmic handgrip exercise at baseline, after 12 weeks of nebivolol (5-20 mg/d) or metoprolol (100-300 mg/d), using a double-blind crossover design." | 5.17 | Differential effects of nebivolol versus metoprolol on functional sympatholysis in hypertensive humans. ( Adams-Huet, B; Arbique, D; Mitchell, JH; Price, A; Raheja, P; Thomas, GD; Victor, RG; Vongpatanasin, W; Wang, Z, 2013) |
| "Eight asthmatic patients were investigated in a double-blind cross-over study after oral administration of 100 mg atenolol, 10 mg metoprolol and placebo." | 5.05 | Cardioselectivity of atenolol and metoprolol. A study in asthmatic patients. ( Löfdahl, CG; Svedmyr, N, 1981) |
| "Metoprolol treatment (60 mg/kg/day via gastric gavage) was started on the second day after surgery and continued until sacrifice at 6 weeks after myocardial infarction." | 1.31 | Metoprolol attenuates postischemic depressed myocardial function in papillary muscles isolated from normal and postinfarction rat hearts. ( Ding, B; Min, JY; Morgan, JP; Sullivan, MF; Wang, JF, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (61.29) | 18.7374 |
| 1990's | 5 (16.13) | 18.2507 |
| 2000's | 3 (9.68) | 29.6817 |
| 2010's | 4 (12.90) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baldwin, JJ | 1 |
| McClure, DE | 1 |
| Gross, DM | 1 |
| Williams, M | 1 |
| Price, A | 2 |
| Raheja, P | 1 |
| Wang, Z | 2 |
| Arbique, D | 2 |
| Adams-Huet, B | 2 |
| Mitchell, JH | 1 |
| Victor, RG | 1 |
| Thomas, GD | 1 |
| Vongpatanasin, W | 2 |
| Guo, Y | 1 |
| Zhang, Y | 2 |
| Shen, N | 1 |
| Zhou, Y | 1 |
| Wupuer, H | 1 |
| He, B | 1 |
| Velasco, A | 1 |
| Solow, E | 1 |
| Arbique, G | 1 |
| Schwedhelm, E | 1 |
| Lindner, JR | 1 |
| Hawkins, MN | 1 |
| Barnes, Q | 1 |
| Purkayastha, S | 1 |
| Eubank, W | 1 |
| Ogoh, S | 1 |
| Raven, PB | 1 |
| Massarsky, A | 1 |
| Trudeau, VL | 1 |
| Moon, TW | 1 |
| Melgar-Fernández, R | 1 |
| Demare, P | 1 |
| Hong, E | 1 |
| Rosas, MA | 1 |
| Escalante, J | 1 |
| Muñoz-Muñiz, O | 1 |
| Juaristi, E | 1 |
| Regla, I | 1 |
| Lundberg, JM | 1 |
| Hua, XY | 1 |
| Franco-Cereceda, A | 1 |
| Dahlöf, C | 1 |
| Ljung, B | 1 |
| Ablad, B | 1 |
| Raine, AE | 1 |
| Vaughan Williams, EM | 1 |
| Alkondon, M | 1 |
| Sivam, SP | 1 |
| Bhatia, S | 1 |
| Sen, P | 1 |
| Kaiser, P | 1 |
| Maggi, CA | 1 |
| Meli, A | 1 |
| Lewis, S | 1 |
| Nygaard, E | 1 |
| Sanchez, J | 1 |
| Egeblad, H | 1 |
| Saltin, B | 1 |
| Löfdahl, CG | 1 |
| Svedmyr, N | 1 |
| Lewis, SF | 1 |
| Taylor, WF | 1 |
| Bastian, BC | 1 |
| Graham, RM | 1 |
| Pettinger, WA | 1 |
| Blomqvist, CG | 1 |
| Cupido, CM | 1 |
| Hicks, AL | 1 |
| McKelvie, RS | 1 |
| Sale, DG | 1 |
| McComas, AJ | 1 |
| Mervaala, EM | 1 |
| Teräväinen, TL | 1 |
| Malmberg, L | 1 |
| Laakso, J | 1 |
| Pörsti, I | 1 |
| Vapaatalo, H | 1 |
| Karppanen, H | 1 |
| Min, JY | 1 |
| Ding, B | 1 |
| Wang, JF | 1 |
| Sullivan, MF | 1 |
| Morgan, JP | 1 |
| Zaagsma, J | 1 |
| Meems, L | 1 |
| Boorsma, M | 1 |
| Grimby, G | 1 |
| Smith, U | 1 |
| Elmér, M | 1 |
| Toda, N | 1 |
| Hayashi, S | 1 |
| Hatano, Y | 1 |
| Okunishi, H | 1 |
| Miyazaki, M | 1 |
| Kowalchuk, JM | 1 |
| Klein, CS | 1 |
| Hughson, RL | 1 |
| Tøttrup, A | 1 |
| Forman, A | 1 |
| Madsen, G | 1 |
| Andersson, KE | 1 |
| Doggrell, SA | 1 |
| Horst, MA | 1 |
| Robinson, CP | 1 |
| Manley, BS | 1 |
| Alexopoulos, D | 1 |
| Robinson, GJ | 1 |
| Cobbe, SM | 1 |
| Abrahamsson, T | 1 |
| Nerme, V | 1 |
| Morita, T | 1 |
| Kondo, S | 1 |
| Tsuchida, S | 1 |
| Weiss, RM | 1 |
| Maiorano, G | 1 |
| Contursi, V | 1 |
| Petrelli, G | 1 |
| Loiacono, N | 1 |
| Bovenzi, F | 1 |
| Ricapito, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Nebivolol Versus Metoprolol on Blood Flow Responses to Exercise and Angiotensin II in Hypertensive Patients[NCT01502787] | Phase 4 | 46 participants (Actual) | Interventional | 2009-04-30 | Completed | ||
| Effects of Nebivolol on Microvascular Perfusion in the Skeletal Muscles During Exercise in Hypertensive Patients[NCT01501929] | Phase 4 | 32 participants (Actual) | Interventional | 2010-08-31 | Completed | ||
| A Pivotal Study To Evaluate The Effectiveness of Isometric Handgrip Therapy In Prehypertensive And Hypertensive Patients[NCT04467879] | 146 participants (Actual) | Interventional | 2020-06-01 | Terminated (stopped due to New Protocol and Outcome Measures in Review) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT01502787)
Timeframe: 12 weeks after initiation of metoprolol
| Intervention | mmHg (Mean) |
|---|---|
| Metoprolol | 114 |
| Nebivolol | 113 |
(NCT01502787)
Timeframe: 12 weeks
| Intervention | mmHg (Mean) |
|---|---|
| Initial Treatment With Metoprolol | 101 |
| Initial Treatment With Nebivolol | 103 |
(NCT01502787)
Timeframe: 12 weeks after each specified medication
| Intervention | ml/min (Mean) |
|---|---|
| First Intervention Metoprolol: 12 Weeks | 96 |
| Second Intervention Nebivolol: 24 Weeks | 105 |
Endothelial cell (EC) was collected after a 20-guage angiocatheter was inserted into the contralateral forearm vein under sterile conditions. Three J-shaped vascular guidewires (St. Jude, St. Paul, MN) were advanced sequentially into the vein up to 10 cm. Endothelial cells were collected by gentle abrasion and placed into a dissociation buffer (0.5% bovine serum albumin, 2mM EDTA, and 100 ug/ml heparin in PBS). Endothelial cells were recovered from the tips of guide wires by repeated washing into collection tubes and subsequent centrifugation. EC were incubated with monoclonal antibodies against the polyclonal antibodies against NADPH oxidase p47 subunit. The intensity of staining was measured using fluorescence microscopy. (NCT01501929)
Timeframe: 12 weeks
| Intervention | Ratio human to HUVEC p47Phox expression (Mean) |
|---|---|
| Metoprolol | 0.47 |
| Nebivolol | 0.44 |
Microvascular perfusion of skeletal muscle were measured during handgrip at 20 cycle per minute after 12 weeks of metoprolol, and after 12 weeks of nebivolol (NCT01501929)
Timeframe: 12 weeks
| Intervention | video intensity units/ second (Median) |
|---|---|
| Metoprolol | 43.938 |
| Nebivolol | 74.584 |
1 review available for metoprolol and Muscle Contraction
| Article | Year |
|---|---|
β-blockers as endocrine disruptors: the potential effects of human β-blockers on aquatic organisms.
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Endocrine Disruptors; Fishes; Gluconeogenesis; Gluco | 2011 |
8 trials available for metoprolol and Muscle Contraction
| Article | Year |
|---|---|
Differential effects of nebivolol versus metoprolol on functional sympatholysis in hypertensive humans.
Topics: Adrenergic beta-1 Receptor Antagonists; Benzopyrans; Blood Pressure; Cross-Over Studies; Double-Blin | 2013 |
Differential effects of nebivolol vs. metoprolol on microvascular function in hypertensive humans.
Topics: Adrenergic beta-1 Receptor Antagonists; Antihypertensive Agents; Cross-Over Studies; Endothelial Cel | 2016 |
The effects of aerobic fitness and beta1-adrenergic receptor blockade on cardiac work during dynamic exercise.
Topics: Adaptation, Physiological; Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-Antagonists; Adul | 2009 |
Physical performance and muscle metabolism during beta-adrenergic blockade in man.
Topics: Adrenergic beta-Antagonists; Adult; Atenolol; Blood Pressure; Clinical Trials as Topic; Energy Metab | 1984 |
Cardioselectivity of atenolol and metoprolol. A study in asthmatic patients.
Topics: Adult; Aged; Asthma; Atenolol; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Female | 1981 |
Haemodynamic responses to static and dynamic handgrip before and after autonomic blockade.
Topics: Adult; Atropine; Autonomic Nerve Block; Epinephrine; Hand; Hemodynamics; Humans; Male; Metoprolol; M | 1983 |
Effect of selective and nonselective beta-blockade on skeletal muscle excitability and fatiguability.
Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-2 Receptor Antagonists; Adrenergic beta-Anta | 1994 |
Beta-blockade and muscle function.
Topics: Adult; Clinical Trials as Topic; Exercise Test; Female; Humans; Male; Metoprolol; Muscle Contraction | 1978 |
22 other studies available for metoprolol and Muscle Contraction
| Article | Year |
|---|---|
Use of (S)-(trifloxymethyl)oxirane in the synthesis of a chiral beta-adrenoceptor antagonist, (R)- and (S)-9-[[3-(tert-butylamino)-2-hydroxypropyl]oximino]fluorene.
Topics: Adrenergic beta-Antagonists; Animals; Binding, Competitive; Chemical Phenomena; Chemistry; Dihydroal | 1982 |
Effects of one month treatment with propranolol and metoprolol on the relaxant and contractile function of isolated trachea from rats exposed to cigarette smoke for four months.
Topics: Acetylcholine; Adrenergic beta-Antagonists; Animals; Lung; Male; Metoprolol; Muscle Contraction; Mus | 2014 |
Synthesis and cardiovascular activity of metoprolol analogues.
Topics: Animals; Aorta; Blood Pressure; Calcium Chloride; Dose-Response Relationship, Drug; Heart Rate; In V | 2004 |
Effects of neuropeptide Y (NPY) on mechanical activity and neurotransmission in the heart, vas deferens and urinary bladder of the guinea-pig.
Topics: Animals; Atropine; Electric Stimulation; Guanethidine; Guinea Pigs; Heart Atria; Male; Metoprolol; M | 1984 |
Pre- and postjunctional beta-adrenoceptor mediated effects on transmitter release and effector response in the isolated rat portal vein.
Topics: Animals; Autacoids; Electric Stimulation; Female; Hypertension; Isoproterenol; Male; Metoprolol; Mus | 1980 |
Adaptation to prolonged beta-blockade of rabbit atrial, purkinje, and ventricular potentials, and of papillary muscle contraction. Time-course of development of and recovery from adaptation.
Topics: Action Potentials; Adrenergic beta-Antagonists; Animals; Electrocardiography; Electrophysiology; Fem | 1981 |
Anticholinesterase effect of sotalol.
Topics: Abdominal Muscles; Acetylcholine; Adrenergic beta-Antagonists; Animals; Carbachol; Cholinesterase In | 1981 |
Modulation by beta-adrenoreceptors of spontaneous contractions of rat urinary bladder.
Topics: Animals; Hexamethonium Compounds; In Vitro Techniques; Isoproterenol; Male; Metoprolol; Muscle Contr | 1982 |
Static contraction of the quadriceps muscle in man: cardiovascular control and responses to one-legged strength training.
Topics: Adaptation, Physiological; Adult; Atropine; Blood Pressure; Echocardiography; Energy Metabolism; Hea | 1984 |
Cardiovascular and renal effects of the combination of felodipine and metoprolol during a high-salt and a moderate-salt diet in spontaneously hypertensive rats.
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Calcium Channel Blockers; Drug Therapy, Combin | 1997 |
Metoprolol attenuates postischemic depressed myocardial function in papillary muscles isolated from normal and postinfarction rat hearts.
Topics: Adrenergic beta-Antagonists; Animals; Calcium; Calcium-Binding Proteins; Calcium-Transporting ATPase | 2001 |
Beta-Adrenoceptor studies. 4. Influence of albumin on in vitro beta-adrenoceptor blocking and antiarrhythmic properties of propranolol, pindolol, practolol and metoprolol.
Topics: Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Guinea Pigs; Heart | 1977 |
Responses of the denervated rat urinary bladder to alfa adrenoceptor stimulation.
Topics: Animals; Denervation; Dihydroergotamine; Electric Stimulation; Male; Methacholine Compounds; Metopro | 1976 |
Selectivity and steric effects of metoprolol isomers on isolated rabbit atria, arteries and tracheal muscles.
Topics: Animals; Arteries; Dogs; Dose-Response Relationship, Drug; Female; Guinea Pigs; Heart Rate; In Vitro | 1978 |
The effect of beta-adrenergic blockade on leg blood flow with repeated maximal contractions of the triceps surae muscle group in man.
Topics: Adrenergic beta-Antagonists; Adult; Heart Rate; Humans; Leg; Male; Metoprolol; Muscle Contraction; O | 1990 |
The actions of some beta-receptor agonists and xanthines on isolated muscle strips from the human oesophago-gastric junction.
Topics: Adenosine; Adrenergic beta-Agonists; Adult; Aged; Dobutamine; Dose-Response Relationship, Drug; Esop | 1990 |
Assessment of the beta 2 adrenoceptor and Ca2+ channel-blocking activity of drugs with the rat portal vein.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dobutamine; Isoproterenol; Male; Metoprolol; Mu | 1990 |
Action of agonists and antagonists on adrenergic receptors in isolated porcine coronary arteries.
Topics: Adrenergic beta-Antagonists; Animals; Coronary Vessels; Dobutamine; Ephedrine; Female; In Vitro Tech | 1985 |
Subsidiary class III effects of beta blockers? A comparison of atenolol, metoprolol, nadolol, oxprenolol and sotalol.
Topics: Action Potentials; Adrenergic beta-Antagonists; Animals; Atenolol; Dose-Response Relationship, Drug; | 1986 |
Beta 1- and beta 2-adrenoceptor affinity and stimulatory effects of (S)-pindolol and iodinated (S)-pindolol.
Topics: Adrenergic beta-Antagonists; Animals; Female; Heart Atria; Heart Rate; In Vitro Techniques; Male; Me | 1987 |
Characterization of functional beta-adrenoceptor subtypes in rabbit urinary bladder smooth muscle.
Topics: Animals; Butoxamine; Dobutamine; Isoproterenol; Male; Metoprolol; Muscle Contraction; Muscle, Smooth | 1986 |
[Clinico-therapeutic evaluation of the hypertensive patient by the isometric exertion test].
Topics: Adult; Antihypertensive Agents; Atenolol; Blood Pressure; Chlorthalidone; Clonidine; Female; Humans; | 1986 |