metoprolol has been researched along with Long QT Syndrome in 21 studies
Metoprolol: A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
metoprolol : A propanolamine that is 1-(propan-2-ylamino)propan-2-ol substituted by a 4-(2-methoxyethyl)phenoxy group at position 1.
Long QT Syndrome: A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To unmask the potential risk of Tdp in a patient with normal or borderline prolongation of QTc interval and recurrent syncope, dobutamine was given intravenously at a rate of 20 microg/kg/min." | 7.75 | Dobutamine infusion for unmasking long QT syndrome and torsades de pointes. ( Cuilan, L; Dayi, H; Kangan, C; Peng, G; Quan, F; Richard, CC, 2009) |
| "Propranolol has a significantly better QTc shortening effect compared to metoprolol and nadolol, especially in patients with prolonged QTc." | 5.38 | Not all beta-blockers are equal in the management of long QT syndrome types 1 and 2: higher recurrence of events under metoprolol. ( Ackerman, MJ; Beckmann, BM; Blom, NA; Chockalingam, P; Clur, SA; Crotti, L; Fischer, M; Girardengo, G; Harris, KM; Hauer, RN; Johnson, JN; Kääb, S; Rordorf, R; Rydberg, A; Schwartz, PJ; Spazzolini, C; van den Heuvel, F; van der Heijden, JF; Wilde, AA, 2012) |
| "Beta-adrenergic receptor antagonists (β-blockers) are the therapy of choice for the long QT syndrome but their efficacy is not homogeneous: propranolol and nadolol are the most effective, whereas metoprolol is associated with more treatment failures." | 3.78 | Nadolol block of Nav1.5 does not explain its efficacy in the long QT syndrome. ( Besana, A; George, AL; Schwartz, PJ; Wang, DW, 2012) |
| " To unmask the potential risk of Tdp in a patient with normal or borderline prolongation of QTc interval and recurrent syncope, dobutamine was given intravenously at a rate of 20 microg/kg/min." | 3.75 | Dobutamine infusion for unmasking long QT syndrome and torsades de pointes. ( Cuilan, L; Dayi, H; Kangan, C; Peng, G; Quan, F; Richard, CC, 2009) |
| "Propranolol has a significantly better QTc shortening effect compared to metoprolol and nadolol, especially in patients with prolonged QTc." | 1.38 | Not all beta-blockers are equal in the management of long QT syndrome types 1 and 2: higher recurrence of events under metoprolol. ( Ackerman, MJ; Beckmann, BM; Blom, NA; Chockalingam, P; Clur, SA; Crotti, L; Fischer, M; Girardengo, G; Harris, KM; Hauer, RN; Johnson, JN; Kääb, S; Rordorf, R; Rydberg, A; Schwartz, PJ; Spazzolini, C; van den Heuvel, F; van der Heijden, JF; Wilde, AA, 2012) |
| "Carvedilol has a class III antiarrhythmic effect, which may provide the rationale for a favourable clinical outcome compared with other beta-blockers as suggested in the recent COMET (Carvedilol Or Metoprolol European Trial) substudy." | 1.33 | Comparison of HERG channel blocking effects of various beta-blockers-- implication for clinical strategy. ( Abe, H; Anson, BD; Delisle, BP; January, CT; Kawakami, K; Kikuchi, K; Nagatomo, T; Nakashima, Y; Takemasa, H, 2006) |
| "However, the incidence of sudden death and aborted sudden death (24% in all patients and 17% in compliant patients) strongly suggests the use of a "back-up" defibrillator, particularly in noncompliant adolescent patients." | 1.30 | Long-term follow-up of patients with long-QT syndrome treated with beta-blockers and continuous pacing. ( Belhassen, B; Dorostkar, PC; Eldar, M; Scheinman, MM, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.76) | 18.7374 |
| 1990's | 2 (9.52) | 18.2507 |
| 2000's | 7 (33.33) | 29.6817 |
| 2010's | 9 (42.86) | 24.3611 |
| 2020's | 2 (9.52) | 2.80 |
| Authors | Studies |
|---|---|
| Bottigliero, D | 1 |
| Monaco, I | 1 |
| Santacroce, R | 1 |
| Casavecchia, G | 1 |
| Correale, M | 1 |
| Guastafierro, F | 1 |
| Leccese, A | 1 |
| Cordisco, G | 1 |
| Ieva, R | 1 |
| Trunzo, R | 1 |
| Di Biase, M | 1 |
| Margaglione, M | 1 |
| Brunetti, ND | 1 |
| Atici, A | 1 |
| Asoğlu, R | 1 |
| Barman, HA | 1 |
| Sahin, I | 1 |
| Gupta, P | 1 |
| Agstam, S | 1 |
| Yadav, A | 1 |
| Ghosh, S | 1 |
| Olberg, HK | 1 |
| Odland, HH | 1 |
| Kask, A | 1 |
| Engelsen, BA | 1 |
| Erbas, O | 1 |
| Yilmaz, M | 1 |
| Abu-Zeitone, A | 1 |
| Peterson, DR | 1 |
| Polonsky, B | 1 |
| McNitt, S | 1 |
| Moss, AJ | 2 |
| Tagawa, M | 1 |
| Ochiai, S | 1 |
| Nakamura, Y | 1 |
| Sato, A | 1 |
| Chinushi, M | 1 |
| Quan, F | 1 |
| Peng, G | 1 |
| Kangan, C | 1 |
| Dayi, H | 1 |
| Cuilan, L | 1 |
| Richard, CC | 1 |
| Bankston, JR | 1 |
| Kass, RS | 1 |
| Besana, A | 1 |
| Wang, DW | 1 |
| George, AL | 1 |
| Schwartz, PJ | 3 |
| Daubert, JP | 1 |
| Grant, AO | 1 |
| Nilsson, KR | 1 |
| Chockalingam, P | 1 |
| Crotti, L | 1 |
| Girardengo, G | 1 |
| Johnson, JN | 1 |
| Harris, KM | 1 |
| van der Heijden, JF | 1 |
| Hauer, RN | 1 |
| Beckmann, BM | 1 |
| Spazzolini, C | 1 |
| Rordorf, R | 1 |
| Rydberg, A | 1 |
| Clur, SA | 1 |
| Fischer, M | 1 |
| van den Heuvel, F | 1 |
| Kääb, S | 1 |
| Blom, NA | 1 |
| Ackerman, MJ | 1 |
| Wilde, AA | 1 |
| Yoshiga, Y | 1 |
| Shimizu, A | 1 |
| Yamagata, T | 1 |
| Hayano, T | 1 |
| Ueyama, T | 1 |
| Ohmura, M | 1 |
| Itagaki, K | 1 |
| Kimura, M | 1 |
| Matsuzaki, M | 1 |
| Etheridge, SP | 1 |
| Shaddy, RE | 1 |
| Ebbehøj, E | 1 |
| Arildsen, H | 1 |
| Hansen, KW | 1 |
| Mogensen, CE | 1 |
| Mølgaard, H | 1 |
| Poulsen, PL | 1 |
| Kawakami, K | 1 |
| Nagatomo, T | 1 |
| Abe, H | 1 |
| Kikuchi, K | 1 |
| Takemasa, H | 1 |
| Anson, BD | 1 |
| Delisle, BP | 1 |
| January, CT | 1 |
| Nakashima, Y | 1 |
| Jacobs, A | 1 |
| Knight, BP | 1 |
| McDonald, KT | 1 |
| Burke, MC | 1 |
| Calle, PA | 1 |
| Buylaert, W | 1 |
| Dorostkar, PC | 1 |
| Eldar, M | 1 |
| Belhassen, B | 1 |
| Scheinman, MM | 1 |
| Zareba, W | 1 |
| Hall, WJ | 1 |
| Crampton, RS | 1 |
| Benhorin, J | 1 |
| Vincent, GM | 1 |
| Locati, EH | 1 |
| Priori, SG | 1 |
| Napolitano, C | 1 |
| Medina, A | 1 |
| Zhang, L | 1 |
| Robinson, JL | 1 |
| Timothy, K | 1 |
| Towbin, JA | 1 |
| Andrews, ML | 1 |
| Edvardsson, N | 1 |
| Olsson, SB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Long QT Syndrome-Population Genetics and Cardiac Studies[NCT00005176] | 2,125 participants (Actual) | Observational | 1985-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metoprolol and Long QT Syndrome
| Article | Year |
|---|---|
Novel AKAP9 mutation and long QT syndrome in a patient with torsades des pointes.
Topics: A Kinase Anchor Proteins; Aged, 80 and over; Cytoskeletal Proteins; Echocardiography, Doppler; Elect | 2019 |
3 trials available for metoprolol and Long QT Syndrome
| Article | Year |
|---|---|
Beta-blocker decreases the increase in QT dispersion and transmural dispersion of repolarization induced by bepridil.
Topics: Adrenergic beta-Antagonists; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Bepridil; Bisoprolol | 2002 |
Effects of metoprolol on QT interval and QT dispersion in Type 1 diabetic patients with abnormal albuminuria.
Topics: Administration, Oral; Adult; Albuminuria; Chronic Disease; Cross-Over Studies; Denmark; Diabetes Mel | 2004 |
Effectiveness and limitations of beta-blocker therapy in congenital long-QT syndrome.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Atenolol; Child; Child, Preschool; Female; Humans; I | 2000 |
17 other studies available for metoprolol and Long QT Syndrome
| Article | Year |
|---|---|
The importance of the epinephrine provocation test for the hidden type-1 congenital long QT syndrome.
Topics: Adolescent; Death, Sudden, Cardiac; DNA; Electrocardiography; Epinephrine; Female; Heterozygote; Hum | 2020 |
Malignant prolongation of the QTc interval due to severe vitamin D deficiency: an unusual presentation.
Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Calcium; Calcium Gluconate; Electrocardiography, Ambu | 2020 |
A woman in her thirties with seizure relapse after a previous diagnosis of epilepsy.
Topics: Adult; Anti-Arrhythmia Agents; Epilepsy; ERG1 Potassium Channel; Female; Humans; Long QT Syndrome; M | 2018 |
Metoprolol and diltiazem ameliorate ziprasidone-induced prolonged corrected QT interval in rats.
Topics: Adrenergic beta-1 Receptor Antagonists; Anesthesia; Animals; Anti-Arrhythmia Agents; Antipsychotic A | 2015 |
Efficacy of different beta-blockers in the treatment of long QT syndrome.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Atenolol; Child; Child, Preschool; Death, Sudden, Ca | 2014 |
Secondly ECG recordings in the emergency room revealed Garenoxacin-induced abnormal QT interval prolongation in a patient with multiple syncopal attacks.
Topics: Adrenergic Agonists; Adrenergic beta-1 Receptor Antagonists; Aged; Anti-Bacterial Agents; Electrocar | 2016 |
Dobutamine infusion for unmasking long QT syndrome and torsades de pointes.
Topics: Adrenergic beta-Agonists; Anti-Arrhythmia Agents; Defibrillators, Implantable; DNA Mutational Analys | 2009 |
Molecular determinants of local anesthetic action of beta-blocking drugs: Implications for therapeutic management of long QT syndrome variant 3.
Topics: Adrenergic beta-Antagonists; Anesthetics, Local; Carbazoles; Carvedilol; Cell Line; Electrophysiolog | 2010 |
Nadolol block of Nav1.5 does not explain its efficacy in the long QT syndrome.
Topics: Adrenergic beta-Antagonists; Cell Line; Humans; Long QT Syndrome; Metoprolol; Mutation; Nadolol; NAV | 2012 |
Novel insights into beta-blocker therapy for long QT syndromes.
Topics: Adrenergic beta-Antagonists; Female; Humans; Long QT Syndrome; Male; Metoprolol; Nadolol; Propranolo | 2012 |
Not all beta-blockers are equal in the management of long QT syndrome types 1 and 2: higher recurrence of events under metoprolol.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Child; Disease-Free Survival; Electrocardiography; F | 2012 |
QT dispersion after beta-blocker therapy (carvedilol or metoprolol) in children with heart failure.
Topics: Adolescent; Adrenergic beta-Antagonists; Carbazoles; Carvedilol; Child; Child Welfare; Child, Presch | 2003 |
Comparison of HERG channel blocking effects of various beta-blockers-- implication for clinical strategy.
Topics: Adrenergic beta-Antagonists; Binding Sites; Carbazoles; Cardiovascular Diseases; Carvedilol; Cell Li | 2006 |
Verapamil decreases ventricular tachyarrhythmias in a patient with Timothy syndrome (LQT8).
Topics: Adrenergic beta-Antagonists; Adult; Calcium Channel Blockers; Combined Modality Therapy; Defibrillat | 2006 |
When an AED meets an ICD... Automated external defibrillator. Implantable cardioverter defibrillator.
Topics: Adult; Anti-Arrhythmia Agents; Cardiomyopathy, Dilated; Cardiopulmonary Resuscitation; Clinical Prot | 1998 |
Long-term follow-up of patients with long-QT syndrome treated with beta-blockers and continuous pacing.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Child; Child, Preschool; Cohort Stud | 1999 |
Induction of delayed repolarization during chronic beta-receptor blockade.
Topics: Aged; Angina Pectoris; Arrhythmias, Cardiac; Electrocardiography; Heart Conduction System; Heart Rat | 1985 |