metoprolol has been researched along with Heart Arrest in 32 studies
Metoprolol: A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
metoprolol : A propanolamine that is 1-(propan-2-ylamino)propan-2-ol substituted by a 4-(2-methoxyethyl)phenoxy group at position 1.
Heart Arrest: Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most cases to normal cardiac rhythm and effective circulation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "During the initial hospitalization, ventricular fibrillation (VF) developed in 6 metoprolol-treated patients (0." | 7.67 | Göteborg Metoprolol Trial: effects on arrhythmias. ( Edvardsson, N; Herlitz, J; Hjalmarson, A; Holmberg, S; Rydén, L; Swedberg, K; Waagstein, F; Waldenström, A, 1984) |
| " In 1987, the Cardiac Arrest Study Hamburg (CASH), a prospective, randomized trial, was initiated to compare metoprolol, amiodarone, propafenone, and ICD implantation in patients surviving sudden cardiac death due to documented ventricular tachycardia and/or ventricular fibrillation." | 5.07 | Preliminary results of the Cardiac Arrest Study Hamburg (CASH). CASH Investigators. ( Cappato, R; Kuck, KH; Rüppel, R; Schneider, MA; Siebels, J, 1993) |
| "We document a pediatric case report of death due to a mixed drug overdose of metoprolol and propafenone, along with data regarding serum metoprolol, alfa-hydroxymetoprolol, and propafenone levels." | 3.85 | Lethal suicide attempt with a mixed-drug intoxication of metoprolol and propafenone - A first pediatric case report. ( Grundmann, M; Handlos, P; Kacirova, I; Kolek, M; Urinovska, R; Vyskocilova-Hrudikova, E, 2017) |
| "During the initial hospitalization, ventricular fibrillation (VF) developed in 6 metoprolol-treated patients (0." | 3.67 | Göteborg Metoprolol Trial: effects on arrhythmias. ( Edvardsson, N; Herlitz, J; Hjalmarson, A; Holmberg, S; Rydén, L; Swedberg, K; Waagstein, F; Waldenström, A, 1984) |
| "During long-term follow-up of cardiac arrest survivors, therapy with an ICD is associated with a 23% (nonsignificant) reduction of all-cause mortality rates when compared with treatment with amiodarone/metoprolol." | 2.69 | Randomized comparison of antiarrhythmic drug therapy with implantable defibrillators in patients resuscitated from cardiac arrest : the Cardiac Arrest Study Hamburg (CASH). ( Cappato, R; Kuck, KH; Rüppel, R; Siebels, J, 2000) |
| "In 1987, the Cardiac Arrest Study Hamburg (CASH), a prospective, multicenter, randomized controlled study, was started in survivors of sudden cardiac death resulting from documented ventricular tachyarrhythmias." | 2.67 | Implantable cardioverter defibrillator compared with antiarrhythmic drug treatment in cardiac arrest survivors (the Cardiac Arrest Study Hamburg). ( Kuck, KH; Siebels, J, 1994) |
| "Despite these therapies, he developed cardiac arrest for 55 minutes, requiring epinephrine (5 mg IV) and vasopressin (40 U IV) with multiple episodes of return of spontaneous circulation." | 1.42 | Successful treatment of metoprolol-induced cardiac arrest with high-dose insulin, lipid emulsion, and ECMO. ( Escajeda, JT; Katz, KD; Rittenberger, JC, 2015) |
| "Metoprolol is a moderately lipophilic β-blocker that in overdose causes direct myocardial depression leading to bradycardia, hypotension, and the potential for cardiovascular collapse." | 1.42 | Successful treatment of a massive metoprolol overdose using intravenous lipid emulsion and hyperinsulinemia/euglycemia therapy. ( Barton, CA; Beauchamp, G; Hendrickson, R; Johnson, NB; Mah, ND, 2015) |
| "MI+metoprolol group had a lower ROSC rate than MI group in the medium dose subgroup, and a higher ROSC rate than MI group in the high dose subgroup." | 1.39 | β-Receptor blocker influences return of spontaneous circulation and chemical examination in rats during cardiopulmonary resuscitation. ( Chen, EX; Gao, YX; Li, LJ; Li, P; Liu, J; Pen, Z; Ren, YX; Zhao, XJ, 2013) |
| "Patients in cardiac arrest are often taking medications affecting adrenergic activity such as the beta blocker metoprolol and the combined alpha and beta blocker, labetalol." | 1.38 | Beta-blockade causes a reduction in the frequency spectrum of VF but improves resuscitation outcome: A potential limitation of quantitative waveform measures. ( Niemann, J; Rosborough, JP; Shah, AP; Sherman, L; Youngquist, ST, 2012) |
| " The latter, however, was taking antiarrhythmic drugs at a dosage less than that proved to be effective during electropharmacological testing." | 1.27 | [Value of a serial electropharmacologic study in survivors of a cardiac arrest secondary to ventricular tachycardia or ventricular fibrillation]. ( Delise, P; Di Pede, F; Piccolo, E; Raviele, A, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (9.38) | 18.7374 |
| 1990's | 12 (37.50) | 18.2507 |
| 2000's | 7 (21.88) | 29.6817 |
| 2010's | 9 (28.13) | 24.3611 |
| 2020's | 1 (3.13) | 2.80 |
| Authors | Studies |
|---|---|
| Juusela, A | 1 |
| Nazir, M | 1 |
| Gimovsky, M | 1 |
| Kacirova, I | 1 |
| Grundmann, M | 1 |
| Kolek, M | 1 |
| Vyskocilova-Hrudikova, E | 1 |
| Urinovska, R | 1 |
| Handlos, P | 1 |
| Zhao, XJ | 1 |
| Pen, Z | 1 |
| Li, P | 1 |
| Chen, EX | 1 |
| Liu, J | 1 |
| Gao, YX | 1 |
| Ren, YX | 1 |
| Li, LJ | 1 |
| Abu-Zeitone, A | 1 |
| Peterson, DR | 1 |
| Polonsky, B | 1 |
| McNitt, S | 1 |
| Moss, AJ | 1 |
| Escajeda, JT | 1 |
| Katz, KD | 1 |
| Rittenberger, JC | 1 |
| Barton, CA | 1 |
| Johnson, NB | 1 |
| Mah, ND | 1 |
| Beauchamp, G | 1 |
| Hendrickson, R | 1 |
| Maskell, KF | 1 |
| Ferguson, NM | 1 |
| Bain, J | 1 |
| Wills, BK | 1 |
| Smith, BB | 1 |
| Nickels, AS | 1 |
| Sviggum, HP | 1 |
| Rolfo, F | 1 |
| Bobbio, M | 1 |
| Angeli, F | 1 |
| Cavallini, C | 1 |
| Alonso-Coello, P | 1 |
| Alvarez, C | 1 |
| Cruz, P | 1 |
| Torán, L | 1 |
| De Nadal, M | 1 |
| Martínez, M | 1 |
| Paniagua, P | 1 |
| Mases, A | 1 |
| Urrutia, G | 1 |
| Peacock, A | 1 |
| Ross, K | 1 |
| Sherman, L | 1 |
| Niemann, J | 1 |
| Youngquist, ST | 1 |
| Shah, AP | 1 |
| Rosborough, JP | 1 |
| Cappato, R | 4 |
| Boczor, S | 1 |
| Kuck, KH | 5 |
| Hohnloser, SH | 1 |
| Dorian, P | 1 |
| Roberts, R | 1 |
| Gent, M | 1 |
| Israel, CW | 1 |
| Fain, E | 1 |
| Champagne, J | 1 |
| Connolly, SJ | 1 |
| Devereaux, PJ | 1 |
| Yang, H | 1 |
| Guyatt, GH | 1 |
| Leslie, K | 1 |
| Villar, JC | 1 |
| Monteri, VM | 1 |
| Choi, P | 1 |
| Giles, JW | 1 |
| Yusuf, S | 1 |
| Jacobs, A | 1 |
| Knight, BP | 1 |
| McDonald, KT | 1 |
| Burke, MC | 1 |
| Raviele, A | 1 |
| Di Pede, F | 1 |
| Delise, P | 1 |
| Piccolo, E | 1 |
| Herlitz, J | 1 |
| Edvardsson, N | 1 |
| Holmberg, S | 1 |
| Rydén, L | 1 |
| Waagstein, F | 1 |
| Waldenström, A | 1 |
| Swedberg, K | 1 |
| Hjalmarson, A | 1 |
| Siebels, J | 4 |
| Rüppel, R | 3 |
| Schneider, MA | 2 |
| Viskin, S | 1 |
| Belhassen, B | 1 |
| Roach, PJ | 1 |
| Magee, MA | 1 |
| Freedman, SB | 1 |
| Sra, JS | 1 |
| Jazayeri, MR | 1 |
| Avitall, B | 1 |
| Dhala, A | 1 |
| Deshpande, S | 1 |
| Blanck, Z | 1 |
| Akhtar, M | 1 |
| Pentousis, D | 1 |
| Cooper, JP | 1 |
| Cobbe, SM | 1 |
| Deal, BJ | 1 |
| Strieper, M | 1 |
| Scagliotti, D | 1 |
| Hulse, E | 1 |
| Auld, D | 1 |
| Campbell, R | 1 |
| Strasburger, JF | 1 |
| Benson, DW | 1 |
| Calle, PA | 1 |
| Buylaert, W | 1 |
| Dangovian, MI | 1 |
| Jarandilla, R | 1 |
| Frumin, H | 1 |
| Kinney, RO | 1 |
| Tai, YT | 1 |
| Lo, CW | 1 |
| Chow, WH | 1 |
| Cheng, CH | 1 |
| Stafford, WJ | 1 |
| Trohman, RG | 1 |
| Bilsker, M | 1 |
| Zaman, L | 1 |
| Castellanos, A | 1 |
| Myerburg, RJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| aMsa and amiOdarone Study in cArdiaC Arrest[NCT04997980] | 500 participants (Anticipated) | Observational | 2015-01-01 | Recruiting | |||
| [NCT00257959] | Phase 4 | 400 participants | Interventional | 2001-01-31 | Completed | ||
| Perioperative Ischemic Evaluation Study (POISE) Trial[NCT00182039] | Phase 3 | 8,351 participants (Actual) | Interventional | 2002-10-31 | Terminated (stopped due to Please see detailed description for reason why study was terminated.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metoprolol and Heart Arrest
| Article | Year |
|---|---|
[The POISE study].
Topics: Adrenergic beta-Antagonists; Bradycardia; Delayed-Action Preparations; Heart Arrest; Humans; Hyperte | 2008 |
6 trials available for metoprolol and Heart Arrest
| Article | Year |
|---|---|
Response to programmed ventricular stimulation and clinical outcome in cardiac arrest survivors receiving randomised assignment to implantable cardioverter defibrillator or antiarrhythmic drug therapy.
Topics: Amiodarone; Anti-Arrhythmia Agents; Defibrillators, Implantable; Electrophysiologic Techniques, Card | 2004 |
Effect of amiodarone and sotalol on ventricular defibrillation threshold: the optimal pharmacological therapy in cardioverter defibrillator patients (OPTIC) trial.
Topics: Adrenergic beta-Antagonists; Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bisoprol | 2006 |
Effect of amiodarone and sotalol on ventricular defibrillation threshold: the optimal pharmacological therapy in cardioverter defibrillator patients (OPTIC) trial.
Topics: Adrenergic beta-Antagonists; Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bisoprol | 2006 |
Effect of amiodarone and sotalol on ventricular defibrillation threshold: the optimal pharmacological therapy in cardioverter defibrillator patients (OPTIC) trial.
Topics: Adrenergic beta-Antagonists; Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bisoprol | 2006 |
Effect of amiodarone and sotalol on ventricular defibrillation threshold: the optimal pharmacological therapy in cardioverter defibrillator patients (OPTIC) trial.
Topics: Adrenergic beta-Antagonists; Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bisoprol | 2006 |
ICD versus drugs in cardiac arrest survivors: preliminary results of the Cardiac Arrest Study Hamburg.
Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Death, Sudden, Cardiac; Defibrillators, Implantable | 1993 |
Implantable cardioverter defibrillator compared with antiarrhythmic drug treatment in cardiac arrest survivors (the Cardiac Arrest Study Hamburg).
Topics: Amiodarone; Anti-Arrhythmia Agents; Death, Sudden, Cardiac; Defibrillators, Implantable; Female; Hea | 1994 |
Preliminary results of the Cardiac Arrest Study Hamburg (CASH). CASH Investigators.
Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Death, Sudden, Cardiac; Defibrillators, Implantable | 1993 |
Randomized comparison of antiarrhythmic drug therapy with implantable defibrillators in patients resuscitated from cardiac arrest : the Cardiac Arrest Study Hamburg (CASH).
Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Defibrillators, Implantable; Female; Heart Arrest; Humans; | 2000 |
25 other studies available for metoprolol and Heart Arrest
| Article | Year |
|---|---|
Two cases of coronavirus 2019-related cardiomyopathy in pregnancy.
Topics: Adult; Anti-Arrhythmia Agents; Antibodies, Monoclonal, Humanized; Anticonvulsants; Blood Gas Analysi | 2020 |
Lethal suicide attempt with a mixed-drug intoxication of metoprolol and propafenone - A first pediatric case report.
Topics: Adolescent; Adrenergic beta-1 Receptor Antagonists; Anti-Arrhythmia Agents; Brain Edema; Cerebral He | 2017 |
β-Receptor blocker influences return of spontaneous circulation and chemical examination in rats during cardiopulmonary resuscitation.
Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Cardiopulmonary Resuscitation; Combined Modality Th | 2013 |
Efficacy of different beta-blockers in the treatment of long QT syndrome.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Atenolol; Child; Child, Preschool; Death, Sudden, Ca | 2014 |
Successful treatment of metoprolol-induced cardiac arrest with high-dose insulin, lipid emulsion, and ECMO.
Topics: Adrenergic beta-1 Receptor Antagonists; Drug Overdose; Extracorporeal Membrane Oxygenation; Fat Emul | 2015 |
Successful treatment of a massive metoprolol overdose using intravenous lipid emulsion and hyperinsulinemia/euglycemia therapy.
Topics: Adrenergic beta-1 Receptor Antagonists; Drug Overdose; Fat Emulsions, Intravenous; Heart Arrest; Hum | 2015 |
Survival After Cardiac Arrest: ECMO Rescue Therapy After Amlodipine and Metoprolol Overdose.
Topics: Adolescent; Adrenergic beta-1 Receptor Antagonists; Amlodipine; Calcium Channel Blockers; Drug Overd | 2017 |
A rare combination of undiagnosed hypertrophic cardiomyopathy revealed by intraoperative anaphylaxis resulting in acute left ventricular outflow obstruction and cardiac arrest.
Topics: Aged; Anaphylaxis; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Cardiomyopathy, Hypertrophic; Echo | 2016 |
[Beta-blockers in patients undergoing noncardiac surgery: implications of the POISE study].
Topics: Adrenergic beta-Antagonists; Bradycardia; Contraindications; Female; Forecasting; Heart; Heart Arres | 2009 |
Pulmonary hypertension: a contraindication to the use of {beta}-adrenoceptor blocking agents.
Topics: Adrenergic beta-Antagonists; Contraindications; Female; Heart Arrest; Humans; Hypertension, Pulmonar | 2010 |
Beta-blockade causes a reduction in the frequency spectrum of VF but improves resuscitation outcome: A potential limitation of quantitative waveform measures.
Topics: Adrenergic beta-Antagonists; Animals; Cardiopulmonary Resuscitation; Confidence Intervals; Disease M | 2012 |
Rationale, design, and organization of the PeriOperative ISchemic Evaluation (POISE) trial: a randomized controlled trial of metoprolol versus placebo in patients undergoing noncardiac surgery.
Topics: Adrenergic beta-Antagonists; Aged; Cardiovascular Diseases; Delayed-Action Preparations; Digestive S | 2006 |
Verapamil decreases ventricular tachyarrhythmias in a patient with Timothy syndrome (LQT8).
Topics: Adrenergic beta-Antagonists; Adult; Calcium Channel Blockers; Combined Modality Therapy; Defibrillat | 2006 |
[Value of a serial electropharmacologic study in survivors of a cardiac arrest secondary to ventricular tachycardia or ventricular fibrillation].
Topics: Adult; Aged; Amiodarone; Death, Sudden; Disopyramide; Drug Therapy, Combination; Electrocardiography | 1984 |
Göteborg Metoprolol Trial: effects on arrhythmias.
Topics: Adult; Aged; Arrhythmias, Cardiac; Clinical Trials as Topic; Double-Blind Method; Female; Heart Arre | 1984 |
Clinical problem-solving. When you only live twice.
Topics: Adult; Death, Sudden, Cardiac; Defibrillators, Implantable; Diagnosis, Differential; Exercise Test; | 1995 |
Asystole and bradycardia during dipyridamole stress testing in patients receiving beta blockers.
Topics: Adrenergic beta-Antagonists; Atenolol; Bradycardia; Dipyridamole; Electrocardiography; Exercise Test | 1993 |
Comparison of cardiac pacing with drug therapy in the treatment of neurocardiogenic (vasovagal) syncope with bradycardia or asystole.
Topics: Adolescent; Adult; Aged; Bradycardia; Cardiac Pacing, Artificial; Disopyramide; Female; Follow-Up St | 1993 |
Prolonged asystole induced by head up tilt test. Report of four cases and brief review of the prognostic significance and medical management.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Anti-Arrhythmia Agents; Disopyramide; Female; Heart | 1997 |
The medical therapy of cardioinhibitory syncope in pediatric patients.
Topics: Adrenergic Agonists; Anti-Arrhythmia Agents; Anti-Inflammatory Agents; Child; Cohort Studies; Disopy | 1997 |
When an AED meets an ICD... Automated external defibrillator. Implantable cardioverter defibrillator.
Topics: Adult; Anti-Arrhythmia Agents; Cardiomyopathy, Dilated; Cardiopulmonary Resuscitation; Clinical Prot | 1998 |
Prolonged asystole during head-up tilt table testing after beta blockade.
Topics: Adrenergic beta-Antagonists; Adult; Bradycardia; Female; Heart Arrest; Humans; Hypotension, Orthosta | 1992 |
Cardiac arrest in an on-call intern.
Topics: Adult; Heart Arrest; Humans; Hypotension, Orthostatic; Male; Metoprolol; Syncope | 1991 |
Successful resuscitation and survival following massive overdose of metoprolol.
Topics: Adult; Drug Overdose; Female; Glucagon; Heart Arrest; Humans; Metoprolol; Pregnancy; Pregnancy Compl | 1990 |
Cardiac arrest in an adolescent with atrial fibrillation and hypertrophic cardiomyopathy.
Topics: Adolescent; Atrial Fibrillation; Cardiac Catheterization; Cardiac Pacing, Artificial; Cardiomyopathy | 1986 |