Page last updated: 2024-10-31

metoprolol and Fasting Hypoglycemia

metoprolol has been researched along with Fasting Hypoglycemia in 32 studies

Metoprolol: A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
metoprolol : A propanolamine that is 1-(propan-2-ylamino)propan-2-ol substituted by a 4-(2-methoxyethyl)phenoxy group at position 1.

Fasting Hypoglycemia: HYPOGLYCEMIA expressed in the postabsorptive state, after prolonged FASTING, or an overnight fast.

Research Excerpts

ExcerptRelevanceReference
"The effect of metoprolol on the counter-regulation of prolonged hypoglycemia was studied in eight insulin-dependent diabetics."9.06Effects of metoprolol on the counter-regulation and recognition of prolonged hypoglycemia in insulin-dependent diabetics. ( Adamson, U; Clausen-Sjöbom, N; Curstedt, T; Hamberger, B; Lins, PE, 1987)
"The effect of the administration of a single oral dose of placebo, oxprenolol and metoprolol on insulin-induced hypoglycemia was investigated in seven insulin-dependent diabetics in a double-blind randomized study."9.05Beta blockade and diabetes mellitus: effect of oxprenolol and metoprolol on the metabolic, cardiovascular, and hormonal response to insulin-induced hypoglycemia in insulin-dependent diabetics. ( Bloom, SR; Keen, H; Viberti, GC, 1980)
"In a double-blind randomized study, the effect of the acute administration of a single oral dose of oxprenolol, a nonselective beta-blocker, and of metoprolol, a beta 1 selective blocker, on insulin-induced hypoglycemia was tested in seven normal subjects."9.05Beta blockade and diabetes mellitus: effect of oxprenolol and metoprolol on the metabolic, cardiovascular, and hormonal response to insulin-induced hypoglycemia in normal subjects. ( Bloom, SR; Keen, H; Viberti, GC, 1980)
" We report a case of a patient receiving the selective beta(1)-adrenergic antagonist, metoprolol, immediately before surgery that was associated with severe hypoglycemia."7.72Hypoglycemia associated with preoperative metoprolol administration. ( Brown, DR; Brown, MJ, 2004)
"The Glycemic Effect in Diabetes Mellitus: Carvedilol-Metoprolol Comparison in Hypertensives (GEMINI) trial compared the metabolic effects of two beta-blockers in people with type 2 diabetes and hypertension treated with renin-angiotensin system (RAS) blockade and found differences in metabolic outcomes."5.12beta-blocker use and diabetes symptom score: results from the GEMINI study. ( Anderson, KM; Bakris, GL; Bell, DS; Dalal, MR; Fonseca, V; Iyengar, M; Katholi, RE; Lukas, MA; McGill, JB; Messerli, FH; Phillips, RA; Raskin, P; Wright, JT, 2007)
"The effect of metoprolol on the counter-regulation of prolonged hypoglycemia was studied in eight insulin-dependent diabetics."5.06Effects of metoprolol on the counter-regulation and recognition of prolonged hypoglycemia in insulin-dependent diabetics. ( Adamson, U; Clausen-Sjöbom, N; Curstedt, T; Hamberger, B; Lins, PE, 1987)
"Two beta-adrenoceptor blocking agents, metoprolol (beta-1-selective) and propranolol (non-selective), were used in the treatment of hyperthyroid patients."5.05Cortisol, growth hormone and prolactin responses to insulin-induced hypoglycaemia in hyperthyroid patients before and during beta-adrenoceptor blockade. ( Anderberg, B; Kågedal, B; Karlberg, BE; Nilsson, OR, 1980)
"The effect of the administration of a single oral dose of placebo, oxprenolol and metoprolol on insulin-induced hypoglycemia was investigated in seven insulin-dependent diabetics in a double-blind randomized study."5.05Beta blockade and diabetes mellitus: effect of oxprenolol and metoprolol on the metabolic, cardiovascular, and hormonal response to insulin-induced hypoglycemia in insulin-dependent diabetics. ( Bloom, SR; Keen, H; Viberti, GC, 1980)
"In a double-blind randomized study, the effect of the acute administration of a single oral dose of oxprenolol, a nonselective beta-blocker, and of metoprolol, a beta 1 selective blocker, on insulin-induced hypoglycemia was tested in seven normal subjects."5.05Beta blockade and diabetes mellitus: effect of oxprenolol and metoprolol on the metabolic, cardiovascular, and hormonal response to insulin-induced hypoglycemia in normal subjects. ( Bloom, SR; Keen, H; Viberti, GC, 1980)
"Hypoglycemia was induced in ten healthy male volunteers during medication with atenolol, metoprolol and propranolol."5.05Blood pressure and pulse response to insulin-induced hypoglycemia during non-selective and selective beta-blockade. ( Anker, E; Bergrem, H; Dahle, K; Jervell, J; Leivestad, T; Myrseth, L; Pape, J; Thaulow, E; Urving, H; vd Lippe, A, 1981)
"Carvedilol administration during pregnancy was associated with neonatal hypoglycemia; however, it did not occur in a time- or dose-dependent manner."4.31α/β- and β-Blocker Exposure in Pregnancy and the Risk of Neonatal Hypoglycemia and Small for Gestational Age. ( Inai, K; Kubota, K; Shimada, E; Shinohara, T, 2023)
"Our findings suggest that neonates born to mothers exposed to β blockers in late pregnancy, including labetalol, are at elevated risk for neonatal hypoglycemia and bradycardia."3.83Late Pregnancy β Blocker Exposure and Risks of Neonatal Hypoglycemia and Bradycardia. ( Bateman, BT; Desai, RJ; Fischer, MA; Hernandez-Diaz, S; Huybrechts, KF; Maeda, A; Mogun, H; Patorno, E; Seely, EW, 2016)
" We report a case of a patient receiving the selective beta(1)-adrenergic antagonist, metoprolol, immediately before surgery that was associated with severe hypoglycemia."3.72Hypoglycemia associated with preoperative metoprolol administration. ( Brown, DR; Brown, MJ, 2004)
"Propranolol-induced hypoglycemia in hemodialysis patients has been increasingly recognized."3.67Effects of propranolol and metoprolol on glucose, cyclic AMP and insulin responses during pharmacologic hyperglucagonemia in hemodialysis patients. ( Pun, KK; Yeung, CK; Yeung, RT, 1985)
" The dose-response curve of isoprenaline/HR was significantly shifted to the right after hypoglycemia."2.68Reduced beta-adrenergic sensitivity in healthy volunteers induced by hypoglycemia. ( Jaeger, R; Jorde, R; Sager, G; Trovik, TS, 1995)
"Metoprolol was given together with the dose of isoprenaline which increased heart rate by 25 beats min-1."2.67Reduced sensitivity to beta-adrenoceptor stimulation and blockade in insulin dependent diabetic patients with hypoglycaemia unawareness. ( Jaeger, R; Jorde, R; Sager, G; Trovik, TS, 1994)
"With metoprolol there is a lesser increase in diastolic blood pressure and a slight tachycardia."1.26Observations in man of hypoglycaemia during selective and non-selective beta-blockade. ( Corrall, RJ; Davidson, NM; French, EB; Shaw, TR, 1977)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-199025 (78.13)18.7374
1990's2 (6.25)18.2507
2000's3 (9.38)29.6817
2010's1 (3.13)24.3611
2020's1 (3.13)2.80

Authors

AuthorsStudies
Kubota, K1
Inai, K1
Shimada, E1
Shinohara, T1
Bateman, BT1
Patorno, E1
Desai, RJ1
Seely, EW1
Mogun, H1
Maeda, A1
Fischer, MA1
Hernandez-Diaz, S1
Huybrechts, KF1
Brown, DR1
Brown, MJ1
McGill, JB1
Bakris, GL1
Fonseca, V1
Raskin, P1
Messerli, FH1
Phillips, RA1
Katholi, RE1
Wright, JT1
Iyengar, M1
Anderson, KM1
Lukas, MA1
Dalal, MR1
Bell, DS1
Nilsson, OR2
Anderberg, B1
Karlberg, BE2
Kågedal, B1
Viberti, GC2
Keen, H2
Bloom, SR2
Lager, I5
Jagenburg, R1
von Schenck, H1
Smith, U4
Pape, J1
Jervell, J1
Anker, E1
Bergrem, H1
Dahle, K1
Leivestad, T1
vd Lippe, A1
Myrseth, L1
Thaulow, E1
Urving, H1
Ostman, J3
Ikegami, H1
Shima, K1
Tanaka, A1
Tahara, Y1
Hirota, M1
Kumahara, Y1
Corrall, RJ3
Webber, RJ1
Frier, BM2
Davidson, NM2
French, EB2
Söderberg, A1
Arner, P2
Haglund, K2
Julin-Dannfelt, A1
Novac, J1
Wennlund, A2
MacDonald, IA1
Bennett, T1
Gale, EA1
Green, JH1
Walford, S1
Juhlin-Dannfelt, A1
Nowak, J1
Shepherd, AM1
Lin, MS1
Keeton, TK1
Blohmé, G2
Lönnroth, P1
Trovik, TS2
Jaeger, R2
Jorde, R2
Sager, G2
Barzel, US1
Shaw, TR1
Hansson, BG2
Dymling, JF1
Manhem, P1
Hökfelt, B2
Heding, LG1
Nilsson, KO1
Odugbesan, O1
Toop, M1
Barnett, AH1
Delacour, JL1
Blanc, PL1
Wagschal, G1
Daoudal, P1
Pun, KK1
Yeung, CK1
Yeung, RT1
Clausen-Sjöbom, N1
Lins, PE1
Adamson, U1
Curstedt, T1
Hamberger, B1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Propranolol as a Treatment for Impaired Awareness of Hypoglycemia in Type 1 Diabetes[NCT03161964]Phase 22 participants (Actual)Interventional2017-10-19Terminated (stopped due to Statistical power could not be achieved due to low enrollment.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for metoprolol and Fasting Hypoglycemia

ArticleYear
beta-adrenergic blockade and diabetes mellitus. A review.
    Acta medica Scandinavica. Supplementum, 1983, Volume: 672

    Topics: Adrenergic beta-Antagonists; Alprenolol; Blood Glucose; Catecholamines; Diabetes Mellitus, Type 1; D

1983

Trials

15 trials available for metoprolol and Fasting Hypoglycemia

ArticleYear
beta-blocker use and diabetes symptom score: results from the GEMINI study.
    Diabetes, obesity & metabolism, 2007, Volume: 9, Issue:3

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Carbazoles; Carvedilol; Cognition; Diab

2007
Cortisol, growth hormone and prolactin responses to insulin-induced hypoglycaemia in hyperthyroid patients before and during beta-adrenoceptor blockade.
    Clinical endocrinology, 1980, Volume: 12, Issue:6

    Topics: Adrenergic beta-Antagonists; Adult; Female; Growth Hormone; Humans; Hydrocortisone; Hyperthyroidism;

1980
Beta blockade and diabetes mellitus: effect of oxprenolol and metoprolol on the metabolic, cardiovascular, and hormonal response to insulin-induced hypoglycemia in insulin-dependent diabetics.
    Metabolism: clinical and experimental, 1980, Volume: 29, Issue:9

    Topics: Adrenergic beta-Antagonists; Adult; Blood Glucose; Blood Pressure; Diabetes Mellitus; Fatty Acids, N

1980
Beta blockade and diabetes mellitus: effect of oxprenolol and metoprolol on the metabolic, cardiovascular, and hormonal response to insulin-induced hypoglycemia in normal subjects.
    Metabolism: clinical and experimental, 1980, Volume: 29, Issue:9

    Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Diabetes Mellitus; Fatty Acids, Nonesterified; F

1980
Effect of beta-blockade on hormone release during hypoglycaemia in insulin-dependent diabetics.
    Acta endocrinologica, 1980, Volume: 95, Issue:3

    Topics: Adrenergic beta-Antagonists; Adult; Alanine; Blood Glucose; Catecholamines; Diabetes Mellitus; Femal

1980
Blood pressure and pulse response to insulin-induced hypoglycemia during non-selective and selective beta-blockade.
    Acta medica Scandinavica. Supplementum, 1981, Volume: 645

    Topics: Adrenergic beta-Antagonists; Adult; Atenolol; Blood Pressure; Heart Rate; Humans; Hypoglycemia; Insu

1981
The effect of propranolol or metoprolol on thermoregulation during insulin-induced hypoglycaemia in man.
    Clinical science (London, England : 1979), 1982, Volume: 63, Issue:3

    Topics: Adult; Body Temperature Regulation; Epinephrine; Heart Rate; Humans; Hypoglycemia; Insulin; Male; Me

1982
Effect of metoprolol and alprenolol on the metabolic, hormonal, and haemodynamic response to insulin-induced hypoglycaemia in hypertensive, insulin-dependent diabetics.
    Acta medica Scandinavica, 1982, Volume: 211, Issue:5

    Topics: Adult; Alprenolol; Diabetes Complications; Diabetes Mellitus; Female; Hemodynamics; Humans; Hyperten

1982
Reduced beta-adrenergic sensitivity in healthy volunteers induced by hypoglycemia.
    Fundamental & clinical pharmacology, 1995, Volume: 9, Issue:2

    Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 1; Dose-Response Relationship, Drug; Humans; Hypoglyce

1995
Reduced sensitivity to beta-adrenoceptor stimulation and blockade in insulin dependent diabetic patients with hypoglycaemia unawareness.
    British journal of clinical pharmacology, 1994, Volume: 38, Issue:5

    Topics: Adult; Analysis of Variance; Awareness; Blood Glucose; Blood Pressure; Chromatography, High Pressure

1994
Effect of cardioselective and non-selective beta-blockade on the hypoglycaemic response in insulin-dependent diabetics.
    Lancet (London, England), 1979, Mar-03, Volume: 1, Issue:8114

    Topics: Adult; Blood Glucose; Blood Pressure; Bradycardia; Clinical Trials as Topic; Diabetes Mellitus; Dias

1979
Long term treatment of moderate hypertension with the beta1-receptor blocking agent metoprolol. II. Effect of submaximal work and insulin-induced hypoglycaemia on plasma catecholamines and renin activity, blood pressure and pulse rate.
    European journal of clinical pharmacology, 1977, Apr-20, Volume: 11, Issue:4

    Topics: Adult; Blood Pressure; Catecholamines; Clinical Trials as Topic; Epinephrine; Hemodynamics; Humans;

1977
Effect of insulin induced hypoglycaemia on the blood levels of catecholamines, glucagon, growth hormone, cortisol, C-peptide and proinsulin before and during medication with the cardioselective beta-receptor blocking agent metoprolol in man.
    Acta endocrinologica, 1978, Volume: 87, Issue:3

    Topics: Adult; C-Peptide; Catecholamines; Clinical Trials as Topic; Glucagon; Growth Hormone; Half-Life; Hum

1978
Beta-and alpha-adrenergic blockade and metabolic responses to insulin induced hypoglycaemia in diabetics.
    Diabetes research (Edinburgh, Scotland), 1987, Volume: 5, Issue:3

    Topics: Blood Glucose; Blood Pressure; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Fatty Acids, Non

1987
Effects of metoprolol on the counter-regulation and recognition of prolonged hypoglycemia in insulin-dependent diabetics.
    Acta medica Scandinavica, 1987, Volume: 222, Issue:1

    Topics: Adult; Blood Pressure; Diabetes Mellitus, Type 1; Female; Heart Rate; Hormones; Humans; Hypoglycemia

1987

Other Studies

16 other studies available for metoprolol and Fasting Hypoglycemia

ArticleYear
α/β- and β-Blocker Exposure in Pregnancy and the Risk of Neonatal Hypoglycemia and Small for Gestational Age.
    Circulation journal : official journal of the Japanese Circulation Society, 2023, 03-24, Volume: 87, Issue:4

    Topics: Adrenergic beta-Antagonists; Carvedilol; Female; Gestational Age; Humans; Hypoglycemia; Infant, Newb

2023
Late Pregnancy β Blocker Exposure and Risks of Neonatal Hypoglycemia and Bradycardia.
    Pediatrics, 2016, Volume: 138, Issue:3

    Topics: Adrenergic beta-Antagonists; Atenolol; Bradycardia; Cohort Studies; Female; Humans; Hypertension; Hy

2016
Hypoglycemia associated with preoperative metoprolol administration.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:5

    Topics: Adrenergic beta-Antagonists; Blood Glucose; Female; Glucose; Humans; Hypoglycemia; Metoprolol; Middl

2004
Adrenergic blockade and hypoglycaemia.
    Acta medica Scandinavica. Supplementum, 1983, Volume: 672

    Topics: Adrenergic beta-Antagonists; Blood Glucose; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Glucag

1983
Effect of three beta-blockers with different pharmacological properties on metabolic, cardiovascular and hormonal response to insulin-induced hypoglycemia in normal subjects.
    Medical journal of Osaka University, 1984, Volume: 35, Issue:1-2

    Topics: Adrenergic beta-Antagonists; Adult; Blood Glucose; Blood Pressure; C-Peptide; Carteolol; Glucagon; G

1984
Increase in coagulation factor VIII activity in man following acute hypoglycaemia: mediation via an adrenergic mechanism.
    British journal of haematology, 1980, Volume: 44, Issue:2

    Topics: Acute Disease; Adult; Blood Coagulation; Factor VIII; Female; Humans; Hypoglycemia; Male; Metoprolol

1980
Hormonal and substrate responses during recovery from hypoglycaemia in man during beta 1-selective and non-selective beta-adrenergic blockade.
    European journal of clinical investigation, 1981, Volume: 11, Issue:4

    Topics: Acetoacetates; Adult; Blood Glucose; Fatty Acids, Nonesterified; Glucagon; Growth Hormone; Humans; H

1981
Plasma catecholamines and cardiovascular responses to hypoglycemia in hyperthyroidism before and during treatment with metoprolol or propranolol.
    The Journal of clinical endocrinology and metabolism, 1980, Volume: 50, Issue:5

    Topics: Adult; Epinephrine; Female; Goiter; Heart Rate; Humans; Hyperthyroidism; Hypoglycemia; Insulin; Kine

1980
A cardio-selective beta blocker (metoprolol) in hypertensive, insulin-dependent diabetics. A preliminary report.
    Acta medica Scandinavica. Supplementum, 1980, Volume: 639

    Topics: Adult; Aged; Blood Glucose; Blood Pressure; Diabetes Mellitus; Female; Humans; Hypertension; Hypogly

1980
Hypoglycemia-induced hypertension in a diabetic patient on metoprolol.
    Annals of internal medicine, 1981, Volume: 94, Issue:3

    Topics: Blood Glucose; Blood Pressure; Diabetes Mellitus; Epinephrine; Humans; Hypoglycemia; Hypotension; Ma

1981
Hypoglycemic symptoms in insulin-dependent diabetics. A prospective study of the influence of beta-blockade.
    Diabete & metabolisme, 1981, Volume: 7, Issue:4

    Topics: Adult; Diabetes Complications; Double-Blind Method; Female; Humans; Hypertension; Hypoglycemia; Male

1981
Hidden danger of generic medications.
    Mayo Clinic proceedings, 2002, Volume: 77, Issue:3

    Topics: Aged; Cost of Illness; Drug Costs; Drugs, Generic; Female; Glyburide; Humans; Hypoglycemia; Hypoglyc

2002
Observations in man of hypoglycaemia during selective and non-selective beta-blockade.
    Scottish medical journal, 1977, Volume: 22, Issue:1

    Topics: Acute Disease; Adrenergic beta-Antagonists; Adult; Blood Glucose; Blood Pressure; Humans; Hypoglycem

1977
Beta blockade in diabetes.
    The New England journal of medicine, 1978, Dec-28, Volume: 299, Issue:26

    Topics: Cardiovascular System; Diabetes Mellitus; Humans; Hypoglycemia; Metoprolol; Propanolamines; Proprano

1978
[Hyperkalemia in acute beta-blocker poisoning].
    Presse medicale (Paris, France : 1983), 1986, Sep-13, Volume: 15, Issue:29

    Topics: Adult; Humans; Hyperkalemia; Hypoglycemia; Male; Metoprolol

1986
Effects of propranolol and metoprolol on glucose, cyclic AMP and insulin responses during pharmacologic hyperglucagonemia in hemodialysis patients.
    Nephron, 1985, Volume: 39, Issue:3

    Topics: Adult; Blood Glucose; Cyclic AMP; Female; Glucagon; Gluconeogenesis; Humans; Hypoglycemia; Insulin;

1985