metoprolol has been researched along with Fasting Hypoglycemia in 32 studies
Metoprolol: A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
metoprolol : A propanolamine that is 1-(propan-2-ylamino)propan-2-ol substituted by a 4-(2-methoxyethyl)phenoxy group at position 1.
Fasting Hypoglycemia: HYPOGLYCEMIA expressed in the postabsorptive state, after prolonged FASTING, or an overnight fast.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of metoprolol on the counter-regulation of prolonged hypoglycemia was studied in eight insulin-dependent diabetics." | 9.06 | Effects of metoprolol on the counter-regulation and recognition of prolonged hypoglycemia in insulin-dependent diabetics. ( Adamson, U; Clausen-Sjöbom, N; Curstedt, T; Hamberger, B; Lins, PE, 1987) |
| "The effect of the administration of a single oral dose of placebo, oxprenolol and metoprolol on insulin-induced hypoglycemia was investigated in seven insulin-dependent diabetics in a double-blind randomized study." | 9.05 | Beta blockade and diabetes mellitus: effect of oxprenolol and metoprolol on the metabolic, cardiovascular, and hormonal response to insulin-induced hypoglycemia in insulin-dependent diabetics. ( Bloom, SR; Keen, H; Viberti, GC, 1980) |
| "In a double-blind randomized study, the effect of the acute administration of a single oral dose of oxprenolol, a nonselective beta-blocker, and of metoprolol, a beta 1 selective blocker, on insulin-induced hypoglycemia was tested in seven normal subjects." | 9.05 | Beta blockade and diabetes mellitus: effect of oxprenolol and metoprolol on the metabolic, cardiovascular, and hormonal response to insulin-induced hypoglycemia in normal subjects. ( Bloom, SR; Keen, H; Viberti, GC, 1980) |
| " We report a case of a patient receiving the selective beta(1)-adrenergic antagonist, metoprolol, immediately before surgery that was associated with severe hypoglycemia." | 7.72 | Hypoglycemia associated with preoperative metoprolol administration. ( Brown, DR; Brown, MJ, 2004) |
| "The Glycemic Effect in Diabetes Mellitus: Carvedilol-Metoprolol Comparison in Hypertensives (GEMINI) trial compared the metabolic effects of two beta-blockers in people with type 2 diabetes and hypertension treated with renin-angiotensin system (RAS) blockade and found differences in metabolic outcomes." | 5.12 | beta-blocker use and diabetes symptom score: results from the GEMINI study. ( Anderson, KM; Bakris, GL; Bell, DS; Dalal, MR; Fonseca, V; Iyengar, M; Katholi, RE; Lukas, MA; McGill, JB; Messerli, FH; Phillips, RA; Raskin, P; Wright, JT, 2007) |
| "The effect of metoprolol on the counter-regulation of prolonged hypoglycemia was studied in eight insulin-dependent diabetics." | 5.06 | Effects of metoprolol on the counter-regulation and recognition of prolonged hypoglycemia in insulin-dependent diabetics. ( Adamson, U; Clausen-Sjöbom, N; Curstedt, T; Hamberger, B; Lins, PE, 1987) |
| "Two beta-adrenoceptor blocking agents, metoprolol (beta-1-selective) and propranolol (non-selective), were used in the treatment of hyperthyroid patients." | 5.05 | Cortisol, growth hormone and prolactin responses to insulin-induced hypoglycaemia in hyperthyroid patients before and during beta-adrenoceptor blockade. ( Anderberg, B; Kågedal, B; Karlberg, BE; Nilsson, OR, 1980) |
| "The effect of the administration of a single oral dose of placebo, oxprenolol and metoprolol on insulin-induced hypoglycemia was investigated in seven insulin-dependent diabetics in a double-blind randomized study." | 5.05 | Beta blockade and diabetes mellitus: effect of oxprenolol and metoprolol on the metabolic, cardiovascular, and hormonal response to insulin-induced hypoglycemia in insulin-dependent diabetics. ( Bloom, SR; Keen, H; Viberti, GC, 1980) |
| "In a double-blind randomized study, the effect of the acute administration of a single oral dose of oxprenolol, a nonselective beta-blocker, and of metoprolol, a beta 1 selective blocker, on insulin-induced hypoglycemia was tested in seven normal subjects." | 5.05 | Beta blockade and diabetes mellitus: effect of oxprenolol and metoprolol on the metabolic, cardiovascular, and hormonal response to insulin-induced hypoglycemia in normal subjects. ( Bloom, SR; Keen, H; Viberti, GC, 1980) |
| "Hypoglycemia was induced in ten healthy male volunteers during medication with atenolol, metoprolol and propranolol." | 5.05 | Blood pressure and pulse response to insulin-induced hypoglycemia during non-selective and selective beta-blockade. ( Anker, E; Bergrem, H; Dahle, K; Jervell, J; Leivestad, T; Myrseth, L; Pape, J; Thaulow, E; Urving, H; vd Lippe, A, 1981) |
| "Carvedilol administration during pregnancy was associated with neonatal hypoglycemia; however, it did not occur in a time- or dose-dependent manner." | 4.31 | α/β- and β-Blocker Exposure in Pregnancy and the Risk of Neonatal Hypoglycemia and Small for Gestational Age. ( Inai, K; Kubota, K; Shimada, E; Shinohara, T, 2023) |
| "Our findings suggest that neonates born to mothers exposed to β blockers in late pregnancy, including labetalol, are at elevated risk for neonatal hypoglycemia and bradycardia." | 3.83 | Late Pregnancy β Blocker Exposure and Risks of Neonatal Hypoglycemia and Bradycardia. ( Bateman, BT; Desai, RJ; Fischer, MA; Hernandez-Diaz, S; Huybrechts, KF; Maeda, A; Mogun, H; Patorno, E; Seely, EW, 2016) |
| " We report a case of a patient receiving the selective beta(1)-adrenergic antagonist, metoprolol, immediately before surgery that was associated with severe hypoglycemia." | 3.72 | Hypoglycemia associated with preoperative metoprolol administration. ( Brown, DR; Brown, MJ, 2004) |
| "Propranolol-induced hypoglycemia in hemodialysis patients has been increasingly recognized." | 3.67 | Effects of propranolol and metoprolol on glucose, cyclic AMP and insulin responses during pharmacologic hyperglucagonemia in hemodialysis patients. ( Pun, KK; Yeung, CK; Yeung, RT, 1985) |
| " The dose-response curve of isoprenaline/HR was significantly shifted to the right after hypoglycemia." | 2.68 | Reduced beta-adrenergic sensitivity in healthy volunteers induced by hypoglycemia. ( Jaeger, R; Jorde, R; Sager, G; Trovik, TS, 1995) |
| "Metoprolol was given together with the dose of isoprenaline which increased heart rate by 25 beats min-1." | 2.67 | Reduced sensitivity to beta-adrenoceptor stimulation and blockade in insulin dependent diabetic patients with hypoglycaemia unawareness. ( Jaeger, R; Jorde, R; Sager, G; Trovik, TS, 1994) |
| "With metoprolol there is a lesser increase in diastolic blood pressure and a slight tachycardia." | 1.26 | Observations in man of hypoglycaemia during selective and non-selective beta-blockade. ( Corrall, RJ; Davidson, NM; French, EB; Shaw, TR, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (78.13) | 18.7374 |
| 1990's | 2 (6.25) | 18.2507 |
| 2000's | 3 (9.38) | 29.6817 |
| 2010's | 1 (3.13) | 24.3611 |
| 2020's | 1 (3.13) | 2.80 |
| Authors | Studies |
|---|---|
| Kubota, K | 1 |
| Inai, K | 1 |
| Shimada, E | 1 |
| Shinohara, T | 1 |
| Bateman, BT | 1 |
| Patorno, E | 1 |
| Desai, RJ | 1 |
| Seely, EW | 1 |
| Mogun, H | 1 |
| Maeda, A | 1 |
| Fischer, MA | 1 |
| Hernandez-Diaz, S | 1 |
| Huybrechts, KF | 1 |
| Brown, DR | 1 |
| Brown, MJ | 1 |
| McGill, JB | 1 |
| Bakris, GL | 1 |
| Fonseca, V | 1 |
| Raskin, P | 1 |
| Messerli, FH | 1 |
| Phillips, RA | 1 |
| Katholi, RE | 1 |
| Wright, JT | 1 |
| Iyengar, M | 1 |
| Anderson, KM | 1 |
| Lukas, MA | 1 |
| Dalal, MR | 1 |
| Bell, DS | 1 |
| Nilsson, OR | 2 |
| Anderberg, B | 1 |
| Karlberg, BE | 2 |
| Kågedal, B | 1 |
| Viberti, GC | 2 |
| Keen, H | 2 |
| Bloom, SR | 2 |
| Lager, I | 5 |
| Jagenburg, R | 1 |
| von Schenck, H | 1 |
| Smith, U | 4 |
| Pape, J | 1 |
| Jervell, J | 1 |
| Anker, E | 1 |
| Bergrem, H | 1 |
| Dahle, K | 1 |
| Leivestad, T | 1 |
| vd Lippe, A | 1 |
| Myrseth, L | 1 |
| Thaulow, E | 1 |
| Urving, H | 1 |
| Ostman, J | 3 |
| Ikegami, H | 1 |
| Shima, K | 1 |
| Tanaka, A | 1 |
| Tahara, Y | 1 |
| Hirota, M | 1 |
| Kumahara, Y | 1 |
| Corrall, RJ | 3 |
| Webber, RJ | 1 |
| Frier, BM | 2 |
| Davidson, NM | 2 |
| French, EB | 2 |
| Söderberg, A | 1 |
| Arner, P | 2 |
| Haglund, K | 2 |
| Julin-Dannfelt, A | 1 |
| Novac, J | 1 |
| Wennlund, A | 2 |
| MacDonald, IA | 1 |
| Bennett, T | 1 |
| Gale, EA | 1 |
| Green, JH | 1 |
| Walford, S | 1 |
| Juhlin-Dannfelt, A | 1 |
| Nowak, J | 1 |
| Shepherd, AM | 1 |
| Lin, MS | 1 |
| Keeton, TK | 1 |
| Blohmé, G | 2 |
| Lönnroth, P | 1 |
| Trovik, TS | 2 |
| Jaeger, R | 2 |
| Jorde, R | 2 |
| Sager, G | 2 |
| Barzel, US | 1 |
| Shaw, TR | 1 |
| Hansson, BG | 2 |
| Dymling, JF | 1 |
| Manhem, P | 1 |
| Hökfelt, B | 2 |
| Heding, LG | 1 |
| Nilsson, KO | 1 |
| Odugbesan, O | 1 |
| Toop, M | 1 |
| Barnett, AH | 1 |
| Delacour, JL | 1 |
| Blanc, PL | 1 |
| Wagschal, G | 1 |
| Daoudal, P | 1 |
| Pun, KK | 1 |
| Yeung, CK | 1 |
| Yeung, RT | 1 |
| Clausen-Sjöbom, N | 1 |
| Lins, PE | 1 |
| Adamson, U | 1 |
| Curstedt, T | 1 |
| Hamberger, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Propranolol as a Treatment for Impaired Awareness of Hypoglycemia in Type 1 Diabetes[NCT03161964] | Phase 2 | 2 participants (Actual) | Interventional | 2017-10-19 | Terminated (stopped due to Statistical power could not be achieved due to low enrollment.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metoprolol and Fasting Hypoglycemia
| Article | Year |
|---|---|
beta-adrenergic blockade and diabetes mellitus. A review.
Topics: Adrenergic beta-Antagonists; Alprenolol; Blood Glucose; Catecholamines; Diabetes Mellitus, Type 1; D | 1983 |
15 trials available for metoprolol and Fasting Hypoglycemia
| Article | Year |
|---|---|
beta-blocker use and diabetes symptom score: results from the GEMINI study.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Carbazoles; Carvedilol; Cognition; Diab | 2007 |
Cortisol, growth hormone and prolactin responses to insulin-induced hypoglycaemia in hyperthyroid patients before and during beta-adrenoceptor blockade.
Topics: Adrenergic beta-Antagonists; Adult; Female; Growth Hormone; Humans; Hydrocortisone; Hyperthyroidism; | 1980 |
Beta blockade and diabetes mellitus: effect of oxprenolol and metoprolol on the metabolic, cardiovascular, and hormonal response to insulin-induced hypoglycemia in insulin-dependent diabetics.
Topics: Adrenergic beta-Antagonists; Adult; Blood Glucose; Blood Pressure; Diabetes Mellitus; Fatty Acids, N | 1980 |
Beta blockade and diabetes mellitus: effect of oxprenolol and metoprolol on the metabolic, cardiovascular, and hormonal response to insulin-induced hypoglycemia in normal subjects.
Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Diabetes Mellitus; Fatty Acids, Nonesterified; F | 1980 |
Effect of beta-blockade on hormone release during hypoglycaemia in insulin-dependent diabetics.
Topics: Adrenergic beta-Antagonists; Adult; Alanine; Blood Glucose; Catecholamines; Diabetes Mellitus; Femal | 1980 |
Blood pressure and pulse response to insulin-induced hypoglycemia during non-selective and selective beta-blockade.
Topics: Adrenergic beta-Antagonists; Adult; Atenolol; Blood Pressure; Heart Rate; Humans; Hypoglycemia; Insu | 1981 |
The effect of propranolol or metoprolol on thermoregulation during insulin-induced hypoglycaemia in man.
Topics: Adult; Body Temperature Regulation; Epinephrine; Heart Rate; Humans; Hypoglycemia; Insulin; Male; Me | 1982 |
Effect of metoprolol and alprenolol on the metabolic, hormonal, and haemodynamic response to insulin-induced hypoglycaemia in hypertensive, insulin-dependent diabetics.
Topics: Adult; Alprenolol; Diabetes Complications; Diabetes Mellitus; Female; Hemodynamics; Humans; Hyperten | 1982 |
Reduced beta-adrenergic sensitivity in healthy volunteers induced by hypoglycemia.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 1; Dose-Response Relationship, Drug; Humans; Hypoglyce | 1995 |
Reduced sensitivity to beta-adrenoceptor stimulation and blockade in insulin dependent diabetic patients with hypoglycaemia unawareness.
Topics: Adult; Analysis of Variance; Awareness; Blood Glucose; Blood Pressure; Chromatography, High Pressure | 1994 |
Effect of cardioselective and non-selective beta-blockade on the hypoglycaemic response in insulin-dependent diabetics.
Topics: Adult; Blood Glucose; Blood Pressure; Bradycardia; Clinical Trials as Topic; Diabetes Mellitus; Dias | 1979 |
Long term treatment of moderate hypertension with the beta1-receptor blocking agent metoprolol. II. Effect of submaximal work and insulin-induced hypoglycaemia on plasma catecholamines and renin activity, blood pressure and pulse rate.
Topics: Adult; Blood Pressure; Catecholamines; Clinical Trials as Topic; Epinephrine; Hemodynamics; Humans; | 1977 |
Effect of insulin induced hypoglycaemia on the blood levels of catecholamines, glucagon, growth hormone, cortisol, C-peptide and proinsulin before and during medication with the cardioselective beta-receptor blocking agent metoprolol in man.
Topics: Adult; C-Peptide; Catecholamines; Clinical Trials as Topic; Glucagon; Growth Hormone; Half-Life; Hum | 1978 |
Beta-and alpha-adrenergic blockade and metabolic responses to insulin induced hypoglycaemia in diabetics.
Topics: Blood Glucose; Blood Pressure; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Fatty Acids, Non | 1987 |
Effects of metoprolol on the counter-regulation and recognition of prolonged hypoglycemia in insulin-dependent diabetics.
Topics: Adult; Blood Pressure; Diabetes Mellitus, Type 1; Female; Heart Rate; Hormones; Humans; Hypoglycemia | 1987 |
16 other studies available for metoprolol and Fasting Hypoglycemia
| Article | Year |
|---|---|
α/β- and β-Blocker Exposure in Pregnancy and the Risk of Neonatal Hypoglycemia and Small for Gestational Age.
Topics: Adrenergic beta-Antagonists; Carvedilol; Female; Gestational Age; Humans; Hypoglycemia; Infant, Newb | 2023 |
Late Pregnancy β Blocker Exposure and Risks of Neonatal Hypoglycemia and Bradycardia.
Topics: Adrenergic beta-Antagonists; Atenolol; Bradycardia; Cohort Studies; Female; Humans; Hypertension; Hy | 2016 |
Hypoglycemia associated with preoperative metoprolol administration.
Topics: Adrenergic beta-Antagonists; Blood Glucose; Female; Glucose; Humans; Hypoglycemia; Metoprolol; Middl | 2004 |
Adrenergic blockade and hypoglycaemia.
Topics: Adrenergic beta-Antagonists; Blood Glucose; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Glucag | 1983 |
Effect of three beta-blockers with different pharmacological properties on metabolic, cardiovascular and hormonal response to insulin-induced hypoglycemia in normal subjects.
Topics: Adrenergic beta-Antagonists; Adult; Blood Glucose; Blood Pressure; C-Peptide; Carteolol; Glucagon; G | 1984 |
Increase in coagulation factor VIII activity in man following acute hypoglycaemia: mediation via an adrenergic mechanism.
Topics: Acute Disease; Adult; Blood Coagulation; Factor VIII; Female; Humans; Hypoglycemia; Male; Metoprolol | 1980 |
Hormonal and substrate responses during recovery from hypoglycaemia in man during beta 1-selective and non-selective beta-adrenergic blockade.
Topics: Acetoacetates; Adult; Blood Glucose; Fatty Acids, Nonesterified; Glucagon; Growth Hormone; Humans; H | 1981 |
Plasma catecholamines and cardiovascular responses to hypoglycemia in hyperthyroidism before and during treatment with metoprolol or propranolol.
Topics: Adult; Epinephrine; Female; Goiter; Heart Rate; Humans; Hyperthyroidism; Hypoglycemia; Insulin; Kine | 1980 |
A cardio-selective beta blocker (metoprolol) in hypertensive, insulin-dependent diabetics. A preliminary report.
Topics: Adult; Aged; Blood Glucose; Blood Pressure; Diabetes Mellitus; Female; Humans; Hypertension; Hypogly | 1980 |
Hypoglycemia-induced hypertension in a diabetic patient on metoprolol.
Topics: Blood Glucose; Blood Pressure; Diabetes Mellitus; Epinephrine; Humans; Hypoglycemia; Hypotension; Ma | 1981 |
Hypoglycemic symptoms in insulin-dependent diabetics. A prospective study of the influence of beta-blockade.
Topics: Adult; Diabetes Complications; Double-Blind Method; Female; Humans; Hypertension; Hypoglycemia; Male | 1981 |
Hidden danger of generic medications.
Topics: Aged; Cost of Illness; Drug Costs; Drugs, Generic; Female; Glyburide; Humans; Hypoglycemia; Hypoglyc | 2002 |
Observations in man of hypoglycaemia during selective and non-selective beta-blockade.
Topics: Acute Disease; Adrenergic beta-Antagonists; Adult; Blood Glucose; Blood Pressure; Humans; Hypoglycem | 1977 |
Beta blockade in diabetes.
Topics: Cardiovascular System; Diabetes Mellitus; Humans; Hypoglycemia; Metoprolol; Propanolamines; Proprano | 1978 |
[Hyperkalemia in acute beta-blocker poisoning].
Topics: Adult; Humans; Hyperkalemia; Hypoglycemia; Male; Metoprolol | 1986 |
Effects of propranolol and metoprolol on glucose, cyclic AMP and insulin responses during pharmacologic hyperglucagonemia in hemodialysis patients.
Topics: Adult; Blood Glucose; Cyclic AMP; Female; Glucagon; Gluconeogenesis; Humans; Hypoglycemia; Insulin; | 1985 |