metoprolol has been researched along with Electrocardiogram QT Prolonged in 21 studies
Metoprolol: A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
metoprolol : A propanolamine that is 1-(propan-2-ylamino)propan-2-ol substituted by a 4-(2-methoxyethyl)phenoxy group at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To unmask the potential risk of Tdp in a patient with normal or borderline prolongation of QTc interval and recurrent syncope, dobutamine was given intravenously at a rate of 20 microg/kg/min." | 7.75 | Dobutamine infusion for unmasking long QT syndrome and torsades de pointes. ( Cuilan, L; Dayi, H; Kangan, C; Peng, G; Quan, F; Richard, CC, 2009) |
| "Propranolol has a significantly better QTc shortening effect compared to metoprolol and nadolol, especially in patients with prolonged QTc." | 5.38 | Not all beta-blockers are equal in the management of long QT syndrome types 1 and 2: higher recurrence of events under metoprolol. ( Ackerman, MJ; Beckmann, BM; Blom, NA; Chockalingam, P; Clur, SA; Crotti, L; Fischer, M; Girardengo, G; Harris, KM; Hauer, RN; Johnson, JN; Kääb, S; Rordorf, R; Rydberg, A; Schwartz, PJ; Spazzolini, C; van den Heuvel, F; van der Heijden, JF; Wilde, AA, 2012) |
| "Beta-adrenergic receptor antagonists (β-blockers) are the therapy of choice for the long QT syndrome but their efficacy is not homogeneous: propranolol and nadolol are the most effective, whereas metoprolol is associated with more treatment failures." | 3.78 | Nadolol block of Nav1.5 does not explain its efficacy in the long QT syndrome. ( Besana, A; George, AL; Schwartz, PJ; Wang, DW, 2012) |
| " To unmask the potential risk of Tdp in a patient with normal or borderline prolongation of QTc interval and recurrent syncope, dobutamine was given intravenously at a rate of 20 microg/kg/min." | 3.75 | Dobutamine infusion for unmasking long QT syndrome and torsades de pointes. ( Cuilan, L; Dayi, H; Kangan, C; Peng, G; Quan, F; Richard, CC, 2009) |
| "Propranolol has a significantly better QTc shortening effect compared to metoprolol and nadolol, especially in patients with prolonged QTc." | 1.38 | Not all beta-blockers are equal in the management of long QT syndrome types 1 and 2: higher recurrence of events under metoprolol. ( Ackerman, MJ; Beckmann, BM; Blom, NA; Chockalingam, P; Clur, SA; Crotti, L; Fischer, M; Girardengo, G; Harris, KM; Hauer, RN; Johnson, JN; Kääb, S; Rordorf, R; Rydberg, A; Schwartz, PJ; Spazzolini, C; van den Heuvel, F; van der Heijden, JF; Wilde, AA, 2012) |
| "Carvedilol has a class III antiarrhythmic effect, which may provide the rationale for a favourable clinical outcome compared with other beta-blockers as suggested in the recent COMET (Carvedilol Or Metoprolol European Trial) substudy." | 1.33 | Comparison of HERG channel blocking effects of various beta-blockers-- implication for clinical strategy. ( Abe, H; Anson, BD; Delisle, BP; January, CT; Kawakami, K; Kikuchi, K; Nagatomo, T; Nakashima, Y; Takemasa, H, 2006) |
| "However, the incidence of sudden death and aborted sudden death (24% in all patients and 17% in compliant patients) strongly suggests the use of a "back-up" defibrillator, particularly in noncompliant adolescent patients." | 1.30 | Long-term follow-up of patients with long-QT syndrome treated with beta-blockers and continuous pacing. ( Belhassen, B; Dorostkar, PC; Eldar, M; Scheinman, MM, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.76) | 18.7374 |
| 1990's | 2 (9.52) | 18.2507 |
| 2000's | 7 (33.33) | 29.6817 |
| 2010's | 9 (42.86) | 24.3611 |
| 2020's | 2 (9.52) | 2.80 |
| Authors | Studies |
|---|---|
| Bottigliero, D | 1 |
| Monaco, I | 1 |
| Santacroce, R | 1 |
| Casavecchia, G | 1 |
| Correale, M | 1 |
| Guastafierro, F | 1 |
| Leccese, A | 1 |
| Cordisco, G | 1 |
| Ieva, R | 1 |
| Trunzo, R | 1 |
| Di Biase, M | 1 |
| Margaglione, M | 1 |
| Brunetti, ND | 1 |
| Atici, A | 1 |
| Asoğlu, R | 1 |
| Barman, HA | 1 |
| Sahin, I | 1 |
| Gupta, P | 1 |
| Agstam, S | 1 |
| Yadav, A | 1 |
| Ghosh, S | 1 |
| Olberg, HK | 1 |
| Odland, HH | 1 |
| Kask, A | 1 |
| Engelsen, BA | 1 |
| Erbas, O | 1 |
| Yilmaz, M | 1 |
| Abu-Zeitone, A | 1 |
| Peterson, DR | 1 |
| Polonsky, B | 1 |
| McNitt, S | 1 |
| Moss, AJ | 2 |
| Tagawa, M | 1 |
| Ochiai, S | 1 |
| Nakamura, Y | 1 |
| Sato, A | 1 |
| Chinushi, M | 1 |
| Quan, F | 1 |
| Peng, G | 1 |
| Kangan, C | 1 |
| Dayi, H | 1 |
| Cuilan, L | 1 |
| Richard, CC | 1 |
| Bankston, JR | 1 |
| Kass, RS | 1 |
| Besana, A | 1 |
| Wang, DW | 1 |
| George, AL | 1 |
| Schwartz, PJ | 3 |
| Daubert, JP | 1 |
| Grant, AO | 1 |
| Nilsson, KR | 1 |
| Chockalingam, P | 1 |
| Crotti, L | 1 |
| Girardengo, G | 1 |
| Johnson, JN | 1 |
| Harris, KM | 1 |
| van der Heijden, JF | 1 |
| Hauer, RN | 1 |
| Beckmann, BM | 1 |
| Spazzolini, C | 1 |
| Rordorf, R | 1 |
| Rydberg, A | 1 |
| Clur, SA | 1 |
| Fischer, M | 1 |
| van den Heuvel, F | 1 |
| Kääb, S | 1 |
| Blom, NA | 1 |
| Ackerman, MJ | 1 |
| Wilde, AA | 1 |
| Yoshiga, Y | 1 |
| Shimizu, A | 1 |
| Yamagata, T | 1 |
| Hayano, T | 1 |
| Ueyama, T | 1 |
| Ohmura, M | 1 |
| Itagaki, K | 1 |
| Kimura, M | 1 |
| Matsuzaki, M | 1 |
| Etheridge, SP | 1 |
| Shaddy, RE | 1 |
| Ebbehøj, E | 1 |
| Arildsen, H | 1 |
| Hansen, KW | 1 |
| Mogensen, CE | 1 |
| Mølgaard, H | 1 |
| Poulsen, PL | 1 |
| Kawakami, K | 1 |
| Nagatomo, T | 1 |
| Abe, H | 1 |
| Kikuchi, K | 1 |
| Takemasa, H | 1 |
| Anson, BD | 1 |
| Delisle, BP | 1 |
| January, CT | 1 |
| Nakashima, Y | 1 |
| Jacobs, A | 1 |
| Knight, BP | 1 |
| McDonald, KT | 1 |
| Burke, MC | 1 |
| Calle, PA | 1 |
| Buylaert, W | 1 |
| Dorostkar, PC | 1 |
| Eldar, M | 1 |
| Belhassen, B | 1 |
| Scheinman, MM | 1 |
| Zareba, W | 1 |
| Hall, WJ | 1 |
| Crampton, RS | 1 |
| Benhorin, J | 1 |
| Vincent, GM | 1 |
| Locati, EH | 1 |
| Priori, SG | 1 |
| Napolitano, C | 1 |
| Medina, A | 1 |
| Zhang, L | 1 |
| Robinson, JL | 1 |
| Timothy, K | 1 |
| Towbin, JA | 1 |
| Andrews, ML | 1 |
| Edvardsson, N | 1 |
| Olsson, SB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Long QT Syndrome-Population Genetics and Cardiac Studies[NCT00005176] | 2,125 participants (Actual) | Observational | 1985-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metoprolol and Electrocardiogram QT Prolonged
| Article | Year |
|---|---|
Novel AKAP9 mutation and long QT syndrome in a patient with torsades des pointes.
Topics: A Kinase Anchor Proteins; Aged, 80 and over; Cytoskeletal Proteins; Echocardiography, Doppler; Elect | 2019 |
3 trials available for metoprolol and Electrocardiogram QT Prolonged
| Article | Year |
|---|---|
Beta-blocker decreases the increase in QT dispersion and transmural dispersion of repolarization induced by bepridil.
Topics: Adrenergic beta-Antagonists; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Bepridil; Bisoprolol | 2002 |
Effects of metoprolol on QT interval and QT dispersion in Type 1 diabetic patients with abnormal albuminuria.
Topics: Administration, Oral; Adult; Albuminuria; Chronic Disease; Cross-Over Studies; Denmark; Diabetes Mel | 2004 |
Effectiveness and limitations of beta-blocker therapy in congenital long-QT syndrome.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Atenolol; Child; Child, Preschool; Female; Humans; I | 2000 |
17 other studies available for metoprolol and Electrocardiogram QT Prolonged
| Article | Year |
|---|---|
The importance of the epinephrine provocation test for the hidden type-1 congenital long QT syndrome.
Topics: Adolescent; Death, Sudden, Cardiac; DNA; Electrocardiography; Epinephrine; Female; Heterozygote; Hum | 2020 |
Malignant prolongation of the QTc interval due to severe vitamin D deficiency: an unusual presentation.
Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Calcium; Calcium Gluconate; Electrocardiography, Ambu | 2020 |
A woman in her thirties with seizure relapse after a previous diagnosis of epilepsy.
Topics: Adult; Anti-Arrhythmia Agents; Epilepsy; ERG1 Potassium Channel; Female; Humans; Long QT Syndrome; M | 2018 |
Metoprolol and diltiazem ameliorate ziprasidone-induced prolonged corrected QT interval in rats.
Topics: Adrenergic beta-1 Receptor Antagonists; Anesthesia; Animals; Anti-Arrhythmia Agents; Antipsychotic A | 2015 |
Efficacy of different beta-blockers in the treatment of long QT syndrome.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Atenolol; Child; Child, Preschool; Death, Sudden, Ca | 2014 |
Secondly ECG recordings in the emergency room revealed Garenoxacin-induced abnormal QT interval prolongation in a patient with multiple syncopal attacks.
Topics: Adrenergic Agonists; Adrenergic beta-1 Receptor Antagonists; Aged; Anti-Bacterial Agents; Electrocar | 2016 |
Dobutamine infusion for unmasking long QT syndrome and torsades de pointes.
Topics: Adrenergic beta-Agonists; Anti-Arrhythmia Agents; Defibrillators, Implantable; DNA Mutational Analys | 2009 |
Molecular determinants of local anesthetic action of beta-blocking drugs: Implications for therapeutic management of long QT syndrome variant 3.
Topics: Adrenergic beta-Antagonists; Anesthetics, Local; Carbazoles; Carvedilol; Cell Line; Electrophysiolog | 2010 |
Nadolol block of Nav1.5 does not explain its efficacy in the long QT syndrome.
Topics: Adrenergic beta-Antagonists; Cell Line; Humans; Long QT Syndrome; Metoprolol; Mutation; Nadolol; NAV | 2012 |
Novel insights into beta-blocker therapy for long QT syndromes.
Topics: Adrenergic beta-Antagonists; Female; Humans; Long QT Syndrome; Male; Metoprolol; Nadolol; Propranolo | 2012 |
Not all beta-blockers are equal in the management of long QT syndrome types 1 and 2: higher recurrence of events under metoprolol.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Child; Disease-Free Survival; Electrocardiography; F | 2012 |
QT dispersion after beta-blocker therapy (carvedilol or metoprolol) in children with heart failure.
Topics: Adolescent; Adrenergic beta-Antagonists; Carbazoles; Carvedilol; Child; Child Welfare; Child, Presch | 2003 |
Comparison of HERG channel blocking effects of various beta-blockers-- implication for clinical strategy.
Topics: Adrenergic beta-Antagonists; Binding Sites; Carbazoles; Cardiovascular Diseases; Carvedilol; Cell Li | 2006 |
Verapamil decreases ventricular tachyarrhythmias in a patient with Timothy syndrome (LQT8).
Topics: Adrenergic beta-Antagonists; Adult; Calcium Channel Blockers; Combined Modality Therapy; Defibrillat | 2006 |
When an AED meets an ICD... Automated external defibrillator. Implantable cardioverter defibrillator.
Topics: Adult; Anti-Arrhythmia Agents; Cardiomyopathy, Dilated; Cardiopulmonary Resuscitation; Clinical Prot | 1998 |
Long-term follow-up of patients with long-QT syndrome treated with beta-blockers and continuous pacing.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Child; Child, Preschool; Cohort Stud | 1999 |
Induction of delayed repolarization during chronic beta-receptor blockade.
Topics: Aged; Angina Pectoris; Arrhythmias, Cardiac; Electrocardiography; Heart Conduction System; Heart Rat | 1985 |