metoprolol has been researched along with Drug Withdrawal Symptoms in 31 studies
Metoprolol: A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
metoprolol : A propanolamine that is 1-(propan-2-ylamino)propan-2-ol substituted by a 4-(2-methoxyethyl)phenoxy group at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| "During the intervening years since metoprolol was first reviewed in the Journal (1977), it has become widely used in the treatment of mild to moderate hypertension and angina pectoris." | 8.77 | Metoprolol. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in hypertension, ischaemic heart disease and related cardiovascular disorders. ( Benfield, P; Brogden, RN; Clissold, SP, 1986) |
| "Transient Left Ventricular Apical Ballooning Syndrome (TLVABS) has been described to occur in response to number of stressful events, drug effects or drug withdrawal." | 5.35 | Transient left ventricular apical ballooning syndrome caused by abrupt metoprolol withdrawal. ( Boguszewski, A; Jefic, D; Koul, D; Martini, W, 2008) |
| "A crossover comparison of metoprolol and hydrochlorothiazide has been performed in 20 patients with mild hypertension." | 5.04 | Comparison of metoprolol as hydrochlorothiazide and antihypertensive agents. ( Pedersen, OL, 1976) |
| "During the intervening years since metoprolol was first reviewed in the Journal (1977), it has become widely used in the treatment of mild to moderate hypertension and angina pectoris." | 4.77 | Metoprolol. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in hypertension, ischaemic heart disease and related cardiovascular disorders. ( Benfield, P; Brogden, RN; Clissold, SP, 1986) |
| "To evaluate the short- and long-term effects of beta-adrenergic blockade (metoprolol) as well as the reaction to withdrawal and readministration of metoprolol in severe heart failure, 33 patients (25 men and eight women; mean age, 47." | 3.67 | Long-term beta-blockade in dilated cardiomyopathy. Effects of short- and long-term metoprolol treatment followed by withdrawal and readministration of metoprolol. ( Bergh, CH; Caidahl, K; Hjalmarson, A; Waagstein, F; Wallentin, I, 1989) |
| "Forty-five patients with congestive heart failure were studied with Holter recordings." | 2.69 | Potential risk of beta-blockade withdrawal in congestive heart failure due to abrupt autonomic changes. ( Andersson, B; Di Lenarda, A; Hjalmarson, A; Rundqvist, B; Sinagra, G; Tygesen, H; Waagstein, F; Wennerblom, B, 1999) |
| "Metoprolol or placebo was gradually withdrawn during 1 week in 115 patients participating in a 3-year, double-blind, postinfarction study." | 2.65 | Rebound phenomena following gradual withdrawal of chronic metoprolol treatment in patients with ischemic heart disease. ( Hjemdahl, P; Olsson, G; Rehnqvist, N, 1984) |
| "Thus, beta-blocker withdrawal symptoms are reproducible and are indicative of a transient sympathetic hyperresponse." | 2.65 | Abrupt withdrawal of beta-blocking agents in patients with arterial hypertension. Effect on blood pressure, heart rate and plasma catecholamines and prolactin. ( Christensen, NJ; Lanng Nielsen, J; Lederballe Pedersen, O; Mikkelsen, E, 1979) |
| "Transient Left Ventricular Apical Ballooning Syndrome (TLVABS) has been described to occur in response to number of stressful events, drug effects or drug withdrawal." | 1.35 | Transient left ventricular apical ballooning syndrome caused by abrupt metoprolol withdrawal. ( Boguszewski, A; Jefic, D; Koul, D; Martini, W, 2008) |
| "Diagnosis of type I-aortic dissection according to DeBakey was achieved by transthoracal echocardiography and computed tomography." | 1.29 | Aortic dissection due to discontinuation of beta-blocker therapy. ( Anelli-Monti, M; Delgado, P; Eber, B; Kaufmann, P; Kullnig, P; Lueger, A; Tscheliessnigg, KH, 1993) |
| "Pindolol was given to 10 hypertensive patients in doses of 10 mg b." | 1.26 | Cardiac hyper- and hyporesponsiveness after pindolol withdrawal. ( Langlois, S; Rangno, RE; Stewart, J, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (70.97) | 18.7374 |
| 1990's | 7 (22.58) | 18.2507 |
| 2000's | 2 (6.45) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chiladakis, JA | 1 |
| Alexopoulos, D | 1 |
| Jefic, D | 1 |
| Koul, D | 1 |
| Boguszewski, A | 1 |
| Martini, W | 1 |
| Manning, AS | 1 |
| Yellon, DM | 1 |
| Coltart, DJ | 1 |
| Hearse, DJ | 1 |
| Rangno, RE | 4 |
| Langlois, S | 4 |
| Johnson, JM | 1 |
| Dow, RJ | 1 |
| Fee, WM | 1 |
| Olsson, G | 3 |
| Hjemdahl, P | 2 |
| Rehnqvist, N | 3 |
| Daleskog, M | 1 |
| Lutterodt, A | 1 |
| Stewart, J | 1 |
| Szécsi, E | 1 |
| Kohlschütter, S | 1 |
| Schiess, W | 1 |
| Lang, E | 1 |
| Li, QP | 1 |
| Rao, MR | 1 |
| Eber, B | 1 |
| Tscheliessnigg, KH | 1 |
| Anelli-Monti, M | 1 |
| Kaufmann, P | 1 |
| Lueger, A | 1 |
| Delgado, P | 1 |
| Kullnig, P | 1 |
| Keltai, M | 1 |
| Török, E | 1 |
| Hajdu, E | 1 |
| Rietiker, S | 1 |
| Eassey, G | 1 |
| Szucs, T | 1 |
| Schneeweiss, A | 1 |
| Shimizu, K | 1 |
| Morimoto, S | 1 |
| Yamada, K | 1 |
| Hiramitsu, S | 1 |
| Uemura, A | 1 |
| Kubo, N | 1 |
| Kimura, K | 1 |
| Kato, Y | 1 |
| Kato, S | 1 |
| Hishida, H | 1 |
| Tygesen, H | 1 |
| Andersson, B | 1 |
| Di Lenarda, A | 1 |
| Rundqvist, B | 1 |
| Sinagra, G | 1 |
| Hjalmarson, A | 2 |
| Waagstein, F | 2 |
| Wennerblom, B | 1 |
| Lederballe Pedersen, O | 2 |
| Mikkelsen, E | 2 |
| Lanng Nielsen, J | 1 |
| Christensen, NJ | 1 |
| Meinertz, T | 1 |
| Just, H | 1 |
| Kasper, W | 1 |
| Kersting, F | 1 |
| Breuing, KH | 1 |
| Beeley, L | 1 |
| Talbot, J | 1 |
| Williams, LC | 1 |
| Turney, JH | 1 |
| Parsons, V | 1 |
| Kristensen, BO | 1 |
| Botting, JH | 1 |
| Gibson, A | 1 |
| Pedersen, OL | 1 |
| Berglund, G | 1 |
| Entman, ML | 1 |
| Caidahl, K | 1 |
| Wallentin, I | 1 |
| Bergh, CH | 1 |
| Benfield, P | 1 |
| Clissold, SP | 1 |
| Brogden, RN | 1 |
| Lindvall, K | 1 |
| Mehta, JL | 1 |
| Lopez, LM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Withdrawal of Beta- Blockers and ACE Inhibitors After Left Ventricular Systolic Function Recovery in Patient With Dilated Cardiomyopathy: A Randomized Control Trial.[NCT02770443] | 22 participants (Actual) | Interventional | 2016-02-19 | Terminated (stopped due to Study closed to recruitment early as endpoints were reached on several participants) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for metoprolol and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Psychiatric uses of antiadrenergic and adrenergic blocking drugs.
Topics: Adult; Alcohol Amnestic Disorder; Antipsychotic Agents; Bipolar Disorder; Clinical Trials as Topic; | 1984 |
Metoprolol. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in hypertension, ischaemic heart disease and related cardiovascular disorders.
Topics: Adult; Age Factors; Aged; Arrhythmias, Cardiac; Cardiomegaly; Coronary Disease; Drug Interactions; D | 1986 |
12 trials available for metoprolol and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Psychiatric uses of antiadrenergic and adrenergic blocking drugs.
Topics: Adult; Alcohol Amnestic Disorder; Antipsychotic Agents; Bipolar Disorder; Clinical Trials as Topic; | 1984 |
Use of beta-blocking agents with group therapy in a smoking withdrawal clinic.
Topics: Adult; Clinical Trials as Topic; Combined Modality Therapy; Double-Blind Method; Female; Humans; Mal | 1984 |
Rebound phenomena following gradual withdrawal of chronic metoprolol treatment in patients with ischemic heart disease.
Topics: Aged; Blood Pressure; Catecholamines; Coronary Disease; Double-Blind Method; Exercise Test; Female; | 1984 |
Unchanged peripheral sympathetic activity following withdrawal of chronic metoprolol treatment. A study of noradrenaline concentrations and kinetics in plasma.
Topics: Aged; Blood Pressure; Heart Rate; Humans; Kinetics; Metabolic Clearance Rate; Metoprolol; Middle Age | 1984 |
Comparison of withdrawal phenomena after propranolol, metoprolol, and pindolol.
Topics: Adult; Aged; Blood Pressure; Heart Rate; Humans; Hypertension; Isoproterenol; Metoprolol; Middle Age | 1982 |
Abrupt withdrawal of pindolol or metoprolol after chronic therapy.
Topics: Adult; Blood Pressure; Drug Hypersensitivity; Electrocardiography; Female; Heart Rate; Humans; Isopr | 1982 |
[First dose response to cilazapril after discontinuation of metoprolol in hypertensive patients].
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Cilazapril; Dose-Response Relations | 1993 |
Potential risk of beta-blockade withdrawal in congestive heart failure due to abrupt autonomic changes.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Electrocardiography, Ambulatory; Female; Follo | 1999 |
Abrupt withdrawal of beta-blocking agents in patients with arterial hypertension. Effect on blood pressure, heart rate and plasma catecholamines and prolactin.
Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Catecholamines; Clinical Trials as Topic; Female | 1979 |
Comparison of metoprolol as hydrochlorothiazide and antihypertensive agents.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Body Weight; Clinical Trials as Topic; Female; Heart | 1976 |
Symptoms and well-being during antihypertensive treatment with thiazide diuretics.
Topics: Aged; Blood Pressure; Diuretics; Double-Blind Method; Female; Health Status; Humans; Hydrochlorothia | 1990 |
Left ventricular function following withdrawal of chronic metoprolol treatment in patients with ischaemic heart disease. A double blind study.
Topics: Aged; Blood Pressure; Clinical Trials as Topic; Coronary Disease; Double-Blind Method; Echocardiogra | 1986 |
18 other studies available for metoprolol and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Autonomic antecedents to variant angina exacerbation after beta-blockade withdrawal.
Topics: Adrenergic beta-Antagonists; Angina Pectoris, Variant; Autonomic Nervous System; Coronary Vasospasm; | 2005 |
Transient left ventricular apical ballooning syndrome caused by abrupt metoprolol withdrawal.
Topics: Cardiomyopathy, Hypertrophic; Female; Humans; Metoprolol; Middle Aged; Substance Withdrawal Syndrome | 2008 |
Abrupt withdrawal of chronic beta-blockade: adaptive changes in cyclic AMP and contractility.
Topics: Adaptation, Physiological; Adrenergic beta-Antagonists; Animals; Cyclic AMP; Heart; Heart Rate; Huma | 1981 |
Comparison of withdrawal phenomena after propranolol, metoprolol and pindolol.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; Heart Rate; Humans; Metoprolol; Middle Age | 1982 |
Metoprolol withdrawal phenomena: mechanism and prevention.
Topics: Adult; Aged; Blood Pressure; Drug Administration Schedule; Epinephrine; Heart Rate; Humans; Isoprote | 1982 |
Cardiac hyper- and hyporesponsiveness after pindolol withdrawal.
Topics: Adult; Blood Pressure; Catecholamines; Female; Heart; Heart Rate; Humans; Isoproterenol; Male; Metop | 1982 |
[Effects of calcium antagonists on withdrawal of beta-receptor blockers in rats during left ventricular hypertrophy].
Topics: Animals; Hemodynamics; Hypertrophy, Left Ventricular; Isomerism; Male; Metoprolol; Myocardium; Nifed | 1995 |
Aortic dissection due to discontinuation of beta-blocker therapy.
Topics: Aortic Aneurysm, Thoracic; Aortic Dissection; Blood Vessel Prosthesis; Hemodynamics; Humans; Hyperte | 1993 |
[Case of dilated cardiomyopathy with marked improvement of the cardiac function with beta block treatment and exacerbation with the interruption of the treatment].
Topics: Adrenergic beta-Antagonists; Cardiomyopathy, Dilated; Heart; Humans; Male; Metoprolol; Middle Aged; | 1997 |
Beta-blocker withdrawal syndrome?
Topics: Angina Pectoris; Humans; Male; Metoprolol; Middle Aged; Myocardial Infarction; Propanolamines; Recur | 1979 |
Beta-blocker withdrawal syndrome?
Topics: Angina Pectoris; Humans; Metoprolol; Nifedipine; Propanolamines; Substance Withdrawal Syndrome | 1979 |
Beta-blocker withdrawal syndrome.
Topics: Aged; Female; Humans; Hypertension; Hypotension, Orthostatic; Metoprolol; Propanolamines; Substance | 1979 |
Beta-blocker withdrawal syndrome?
Topics: Atenolol; Humans; Male; Metoprolol; Propanolamines; Propranolol; Substance Withdrawal Syndrome | 1979 |
Beta-blocker withdrawal syndrome.
Topics: Humans; Metoprolol; Nifedipine; Propanolamines; Propranolol; Pyridines; Substance Withdrawal Syndrom | 1979 |
Beta-blocker withdrawal syndrome.
Topics: Animals; Drug Hypersensitivity; Heart Rate; Humans; Metoprolol; Propanolamines; Rats; Rest; Substanc | 1979 |
Alprazolam withdrawal.
Topics: Alprazolam; Coronary Disease; Female; Humans; Metoprolol; Seizures; Substance Withdrawal Syndrome | 1990 |
Long-term beta-blockade in dilated cardiomyopathy. Effects of short- and long-term metoprolol treatment followed by withdrawal and readministration of metoprolol.
Topics: Adolescent; Adult; Aged; Cardiac Catheterization; Cardiomyopathy, Dilated; Drug Evaluation; Echocard | 1989 |
Rebound hypertension following abrupt cessation of clonidine and metoprolol. Treatment with labetalol.
Topics: Aged; Clonidine; Humans; Hypertension; Labetalol; Male; Metoprolol; Substance Withdrawal Syndrome | 1987 |