metoprolol has been researched along with Drug Overdose in 24 studies
Metoprolol: A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
metoprolol : A propanolamine that is 1-(propan-2-ylamino)propan-2-ol substituted by a 4-(2-methoxyethyl)phenoxy group at position 1.
Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We document a pediatric case report of death due to a mixed drug overdose of metoprolol and propafenone, along with data regarding serum metoprolol, alfa-hydroxymetoprolol, and propafenone levels." | 3.85 | Lethal suicide attempt with a mixed-drug intoxication of metoprolol and propafenone - A first pediatric case report. ( Grundmann, M; Handlos, P; Kacirova, I; Kolek, M; Urinovska, R; Vyskocilova-Hrudikova, E, 2017) |
| " In this case report we describe the use of high-dose insulin (10 IU/kg per hour) in a case of massive metoprolol ingestion (5g) in which hypotension was unresponsive to conventional therapies." | 3.75 | The use of high-dose insulin-glucose euglycemia in beta-blocker overdose: a case report. ( Hacket, LP; Isbister, GK; Page, C, 2009) |
| " Insulin was infused for a total of approximately 37 hours, most of which was dosed at 10 U/kg/hour; following discontinuation, serial serum insulin levels were drawn and remained at supraphysiologic levels for at least 24 hours and well above reference range for multiple days thereafter." | 1.56 | Persistent Hyperinsulinemia Following High-Dose Insulin Therapy: A Case Report. ( Bangh, SA; Cole, JB; Corcoran, JN; Jacoby, KJ; Olives, TD, 2020) |
| "Despite these therapies, he developed cardiac arrest for 55 minutes, requiring epinephrine (5 mg IV) and vasopressin (40 U IV) with multiple episodes of return of spontaneous circulation." | 1.42 | Successful treatment of metoprolol-induced cardiac arrest with high-dose insulin, lipid emulsion, and ECMO. ( Escajeda, JT; Katz, KD; Rittenberger, JC, 2015) |
| "Metoprolol is a moderately lipophilic β-blocker that in overdose causes direct myocardial depression leading to bradycardia, hypotension, and the potential for cardiovascular collapse." | 1.42 | Successful treatment of a massive metoprolol overdose using intravenous lipid emulsion and hyperinsulinemia/euglycemia therapy. ( Barton, CA; Beauchamp, G; Hendrickson, R; Johnson, NB; Mah, ND, 2015) |
| "Propranolol was the only beta blocker associated with seizure; of those who ingested more than 2 g of propranolol, two thirds had a seizure." | 1.29 | Relative toxicity of beta blockers in overdose. ( Buckley, NA; Dawson, AH; Epid, D; Reith, DM; Sayer, GP; Whyte, IM, 1996) |
| "Metoprolol was extracted from postmortem specimens and derivatized with the chiral reagent 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl isothiocyanate." | 1.29 | Distribution of metoprolol enantiomers in a fatal overdose. ( Jones, G; Mozayani, A; Singer, P, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (25.00) | 18.2507 |
| 2000's | 3 (12.50) | 29.6817 |
| 2010's | 13 (54.17) | 24.3611 |
| 2020's | 2 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Corcoran, JN | 1 |
| Jacoby, KJ | 1 |
| Olives, TD | 1 |
| Bangh, SA | 1 |
| Cole, JB | 2 |
| Salam, S | 1 |
| Nornhold, B | 1 |
| Mallat, J | 1 |
| Carroll, C | 1 |
| Hassanin, A | 1 |
| Chenoweth, JA | 1 |
| Colby, DK | 1 |
| Sutter, ME | 1 |
| Radke, JB | 1 |
| Ford, JB | 1 |
| Nilas Young, J | 1 |
| Richards, JR | 1 |
| Kacirova, I | 1 |
| Grundmann, M | 1 |
| Kolek, M | 1 |
| Vyskocilova-Hrudikova, E | 1 |
| Urinovska, R | 1 |
| Handlos, P | 1 |
| Nordmark Grass, J | 1 |
| Ahlner, J | 1 |
| Kugelberg, FC | 1 |
| Steinwall, J | 1 |
| Forsman, P | 1 |
| Lindeman, E | 1 |
| Calzadilla, A | 1 |
| Badiye, A | 1 |
| Ghodsizad, A | 1 |
| Bernstein, J | 1 |
| Campos, M | 1 |
| Mirsaeidi, M | 1 |
| Li, SF | 1 |
| Edwards, L | 1 |
| Nguyen, V | 1 |
| Eren Cevik, S | 1 |
| Tasyurek, T | 1 |
| Guneysel, O | 1 |
| Escajeda, JT | 1 |
| Katz, KD | 1 |
| Rittenberger, JC | 1 |
| Barton, CA | 1 |
| Johnson, NB | 1 |
| Mah, ND | 1 |
| Beauchamp, G | 1 |
| Hendrickson, R | 1 |
| Maskell, KF | 1 |
| Ferguson, NM | 1 |
| Bain, J | 1 |
| Wills, BK | 1 |
| Page, C | 1 |
| Hacket, LP | 1 |
| Isbister, GK | 1 |
| Senthilkumaran, S | 1 |
| Balamurgan, N | 1 |
| Sweni, S | 1 |
| Thirumalaikolundusubramanian, P | 1 |
| Stellpflug, SJ | 1 |
| Fritzlar, SJ | 1 |
| Engebretsen, KM | 1 |
| Holger, JS | 1 |
| Ramdas, S | 1 |
| Riesenberg, LA | 1 |
| Jasani, N | 1 |
| Kinoshita, H | 1 |
| Taniguchi, T | 1 |
| Nishiguchi, M | 1 |
| Ouchi, H | 1 |
| Minami, T | 1 |
| Utsumi, T | 1 |
| Motomura, H | 1 |
| Tsuda, T | 1 |
| Ohta, T | 1 |
| Aoki, S | 1 |
| Komeda, M | 1 |
| Kamamoto, T | 1 |
| Kubota, A | 1 |
| Fuke, C | 1 |
| Arao, T | 1 |
| Miyazaki, T | 1 |
| Hishida, S | 1 |
| Wnek, W | 1 |
| Love, JN | 1 |
| Almási, R | 1 |
| Mágel, F | 1 |
| Kósik, G | 1 |
| Reith, DM | 1 |
| Dawson, AH | 1 |
| Epid, D | 1 |
| Whyte, IM | 1 |
| Buckley, NA | 1 |
| Sayer, GP | 1 |
| Mozayani, A | 1 |
| Singer, P | 1 |
| Jones, G | 1 |
| Hoeper, MM | 1 |
| Boeker, KH | 1 |
| Tai, YT | 1 |
| Lo, CW | 1 |
| Chow, WH | 1 |
| Cheng, CH | 1 |
1 review available for metoprolol and Drug Overdose
| Article | Year |
|---|---|
Massive metoprolol overdose requiring ECMO: brief review of the evidence behind recommended treatments.
Topics: Drug Overdose; Extracorporeal Membrane Oxygenation; Fat Emulsions, Intravenous; Humans; Male; Metopr | 2021 |
23 other studies available for metoprolol and Drug Overdose
| Article | Year |
|---|---|
Persistent Hyperinsulinemia Following High-Dose Insulin Therapy: A Case Report.
Topics: Adrenergic beta-1 Receptor Antagonists; Amlodipine; Bradycardia; Calcium Channel Blockers; Drug Admi | 2020 |
Polypharmacy in the Elderly-When Good Drugs Lead to Bad Outcomes: A Teachable Moment.
Topics: Aged, 80 and over; Anti-Arrhythmia Agents; Antihypertensive Agents; Atorvastatin; Atrial Fibrillatio | 2017 |
Massive diltiazem and metoprolol overdose rescued with extracorporeal life support.
Topics: Adult; Anti-Arrhythmia Agents; Diltiazem; Dose-Response Relationship, Drug; Drug Overdose; Extracorp | 2017 |
Lethal suicide attempt with a mixed-drug intoxication of metoprolol and propafenone - A first pediatric case report.
Topics: Adolescent; Adrenergic beta-1 Receptor Antagonists; Anti-Arrhythmia Agents; Brain Edema; Cerebral He | 2017 |
A case of massive metoprolol and amlodipine overdose with blood concentrations and survival following extracorporeal corporeal membrane oxygenation (ECMO).
Topics: Adult; Amlodipine; Drug Overdose; Extracorporeal Membrane Oxygenation; Female; Humans; Metoprolol; S | 2019 |
A Young Woman with Bradycardia and Hypotension.
Topics: Adrenergic beta-1 Receptor Antagonists; Analgesics, Opioid; Benzodiazepines; Bradycardia; Central Ne | 2018 |
Treatment of caffeine toxicity with metoprolol.
Topics: Adult; Anti-Arrhythmia Agents; Caffeine; Drug Overdose; Electrocardiography; Emergency Service, Hosp | 2019 |
Intralipid emulsion treatment as an antidote in lipophilic drug intoxications.
Topics: Adolescent; Adult; Alprazolam; Amitriptyline; Antidotes; Blood Pressure; Dibenzothiazepines; Drug Ov | 2014 |
Successful treatment of metoprolol-induced cardiac arrest with high-dose insulin, lipid emulsion, and ECMO.
Topics: Adrenergic beta-1 Receptor Antagonists; Drug Overdose; Extracorporeal Membrane Oxygenation; Fat Emul | 2015 |
Successful treatment of a massive metoprolol overdose using intravenous lipid emulsion and hyperinsulinemia/euglycemia therapy.
Topics: Adrenergic beta-1 Receptor Antagonists; Drug Overdose; Fat Emulsions, Intravenous; Heart Arrest; Hum | 2015 |
Survival After Cardiac Arrest: ECMO Rescue Therapy After Amlodipine and Metoprolol Overdose.
Topics: Adolescent; Adrenergic beta-1 Receptor Antagonists; Amlodipine; Calcium Channel Blockers; Drug Overd | 2017 |
The use of high-dose insulin-glucose euglycemia in beta-blocker overdose: a case report.
Topics: Adrenergic beta-Antagonists; Antidotes; Blood Glucose; Blood Pressure; Critical Care; Drug Administr | 2009 |
Acute episode of reversible blindness after an overdose of beta blockers and calcium channel antagonist.
Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Blindness; Calcium Channel Blockers; Drug Overdose; F | 2011 |
Cardiotoxic overdose treated with intravenous fat emulsion and high-dose insulin in the setting of hypertrophic cardiomyopathy.
Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Amiodarone; Cardiomyopathy, Hypertrophic; Cardiotoxin | 2011 |
Drug overdose with refractory bradycardia and hypotension.
Topics: Antihypertensive Agents; Bradycardia; Clonazepam; Diltiazem; Drug Overdose; Female; GABA Modulators; | 2011 |
An autopsy case of combined drug intoxication involving verapamil, metoprolol and digoxin.
Topics: Adrenergic beta-Antagonists; Adult; Anti-Arrhythmia Agents; Calcium Channel Blockers; Digoxin; Drug | 2003 |
[The use of intra-aortic balloon counterpulsation in the treatment of severe hemodynamic instability from myocardial depressant drug overdose].
Topics: Adult; Antihypertensive Agents; Bradycardia; Counterpulsation; Diltiazem; Drug Overdose; Fatal Outco | 2003 |
Beta-blocker toxicity: a clinical diagnosis.
Topics: Adult; Drug Overdose; Electrocardiography; Humans; Male; Metoprolol; Suicide, Attempted | 1994 |
[Cardiogenic shock and ventricular fibrillation induced by prajmalium and metoprolol poisoning].
Topics: Adult; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Drug Overdose; Drug Synergism; Huma | 1996 |
Relative toxicity of beta blockers in overdose.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Child, Preschool; Databases, Factual | 1996 |
Distribution of metoprolol enantiomers in a fatal overdose.
Topics: Adolescent; Adrenergic beta-Antagonists; Calibration; Drug Overdose; Female; Forensic Medicine; Gast | 1995 |
Overdose of metoprolol treated with enoximone.
Topics: Adrenergic beta-Antagonists; Cardiotonic Agents; Drug Overdose; Enoximone; Female; Humans; Metoprolo | 1996 |
Successful resuscitation and survival following massive overdose of metoprolol.
Topics: Adult; Drug Overdose; Female; Glucagon; Heart Arrest; Humans; Metoprolol; Pregnancy; Pregnancy Compl | 1990 |