metoprolol has been researched along with Diabetes Mellitus, Type 1 in 17 studies
Metoprolol: A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
metoprolol : A propanolamine that is 1-(propan-2-ylamino)propan-2-ol substituted by a 4-(2-methoxyethyl)phenoxy group at position 1.
Diabetes Mellitus, Type 1: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of metoprolol on the counter-regulation of prolonged hypoglycemia was studied in eight insulin-dependent diabetics." | 9.06 | Effects of metoprolol on the counter-regulation and recognition of prolonged hypoglycemia in insulin-dependent diabetics. ( Adamson, U; Clausen-Sjöbom, N; Curstedt, T; Hamberger, B; Lins, PE, 1987) |
| "Metoprolol treatment improved in vagal tone assessed by short-term spectral analysis." | 6.70 | Effects on heart rate variability of metoprolol supplementary to ongoing ACE-inhibitor treatment in Type I diabetic patients with abnormal albuminuria. ( Ebbehøj, E; Hansen, KW; Knudsen, ST; Mogensen, CE; Mølgaard, H; Poulsen, PL, 2002) |
| "8 years) with microalbuminuria 31 (19-160) microg/min were randomised to treatment with enalapril (group 1, n = 7) or metoprolol (group 2, n = 6)." | 5.09 | Effect of angiotensin converting enzyme inhibitor or beta blocker on glomerular structural changes in young microalbuminuric patients with Type I (insulin-dependent) diabetes mellitus. ( Bangstad, HJ; Dahlquist, G; Osterby, R; Persson, B; Rudberg, S, 1999) |
| "The effect of metoprolol on the counter-regulation of prolonged hypoglycemia was studied in eight insulin-dependent diabetics." | 5.06 | Effects of metoprolol on the counter-regulation and recognition of prolonged hypoglycemia in insulin-dependent diabetics. ( Adamson, U; Clausen-Sjöbom, N; Curstedt, T; Hamberger, B; Lins, PE, 1987) |
| "Metoprolol treatment improved in vagal tone assessed by short-term spectral analysis." | 2.70 | Effects on heart rate variability of metoprolol supplementary to ongoing ACE-inhibitor treatment in Type I diabetic patients with abnormal albuminuria. ( Ebbehøj, E; Hansen, KW; Knudsen, ST; Mogensen, CE; Mølgaard, H; Poulsen, PL, 2002) |
| " The dose-response curve of isoprenaline/HR was significantly shifted to the right after hypoglycemia." | 2.68 | Reduced beta-adrenergic sensitivity in healthy volunteers induced by hypoglycemia. ( Jaeger, R; Jorde, R; Sager, G; Trovik, TS, 1995) |
| "Metoprolol was given together with the dose of isoprenaline which increased heart rate by 25 beats min-1." | 2.67 | Reduced sensitivity to beta-adrenoceptor stimulation and blockade in insulin dependent diabetic patients with hypoglycaemia unawareness. ( Jaeger, R; Jorde, R; Sager, G; Trovik, TS, 1994) |
| "However, in IDDM with blunted plasma glucagon responses, postnadir plasma glucose recovery was further decreased by propranolol (14 +/- 0." | 1.27 | The adrenergic contribution to glucose counterregulation in type I diabetes mellitus. Dependency on A-cell function and mediation through beta 2-adrenergic receptors. ( Angeletti, G; Bolli, G; Brunetti, P; Compagnucci, P; De Cosmo, S; De Feo, P; Gerich, JE; Motolese, M; Perriello, G; Santeusanio, F, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (29.41) | 18.7374 |
| 1990's | 8 (47.06) | 18.2507 |
| 2000's | 4 (23.53) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ebbehøj, E | 2 |
| Poulsen, PL | 2 |
| Hansen, KW | 3 |
| Knudsen, ST | 1 |
| Mølgaard, H | 2 |
| Mogensen, CE | 3 |
| Arildsen, H | 1 |
| Lager, I | 1 |
| Ostman, J | 1 |
| De Feo, P | 1 |
| Bolli, G | 1 |
| Perriello, G | 1 |
| De Cosmo, S | 1 |
| Compagnucci, P | 1 |
| Angeletti, G | 1 |
| Santeusanio, F | 1 |
| Gerich, JE | 1 |
| Motolese, M | 1 |
| Brunetti, P | 1 |
| Trovik, TS | 2 |
| Jaeger, R | 2 |
| Jorde, R | 3 |
| Sager, G | 3 |
| Rudberg, S | 4 |
| Sätterström, G | 1 |
| Dahlqvist, R | 1 |
| Dahlquist, G | 2 |
| Olbrich, A | 1 |
| Salameh, A | 1 |
| Roesen, P | 1 |
| Dhein, S | 1 |
| Osterby, R | 3 |
| Bangstad, HJ | 3 |
| Persson, B | 1 |
| Nyberg, G | 1 |
| Gulmann, C | 1 |
| Vea, H | 1 |
| Vaaler, S | 1 |
| Sundsfjord, J | 1 |
| Teschner, M | 1 |
| Schaefer, RM | 1 |
| Bahner, U | 1 |
| Heidland, A | 1 |
| Pedersen, MM | 1 |
| Christensen, CK | 1 |
| Christiansen, JS | 1 |
| Friedman, PJ | 1 |
| Dunn, PJ | 1 |
| Jury, DR | 1 |
| Clausen-Sjöbom, N | 1 |
| Lins, PE | 1 |
| Adamson, U | 1 |
| Curstedt, T | 1 |
| Hamberger, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Propranolol as a Treatment for Impaired Awareness of Hypoglycemia in Type 1 Diabetes[NCT03161964] | Phase 2 | 2 participants (Actual) | Interventional | 2017-10-19 | Terminated (stopped due to Statistical power could not be achieved due to low enrollment.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for metoprolol and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
beta-adrenergic blockade and diabetes mellitus. A review.
Topics: Adrenergic beta-Antagonists; Alprenolol; Blood Glucose; Catecholamines; Diabetes Mellitus, Type 1; D | 1983 |
[Nephropathy in type 1 diabetes mellitus. Current experimental and clinical aspects].
Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Diabetes Mellitus, Experimental; Dia | 1992 |
8 trials available for metoprolol and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Effects on heart rate variability of metoprolol supplementary to ongoing ACE-inhibitor treatment in Type I diabetic patients with abnormal albuminuria.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Albuminuria; Angiotensin-Converting Enzyme Inhibitor | 2002 |
Effects of metoprolol on QT interval and QT dispersion in Type 1 diabetic patients with abnormal albuminuria.
Topics: Administration, Oral; Adult; Albuminuria; Chronic Disease; Cross-Over Studies; Denmark; Diabetes Mel | 2004 |
Reduced beta-adrenergic sensitivity in healthy volunteers induced by hypoglycemia.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 1; Dose-Response Relationship, Drug; Humans; Hypoglyce | 1995 |
Reduced sensitivity to beta-adrenoceptor stimulation and blockade in insulin dependent diabetic patients with hypoglycaemia unawareness.
Topics: Adult; Analysis of Variance; Awareness; Blood Glucose; Blood Pressure; Chromatography, High Pressure | 1994 |
Indomethacin but not metoprolol reduces exercise-induced albumin excretion rate in type 1 diabetic patients with microalbuminuria.
Topics: Adult; Albuminuria; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 1; Diabetic Nephropathies | 1993 |
Effect of angiotensin converting enzyme inhibitor or beta blocker on glomerular structural changes in young microalbuminuric patients with Type I (insulin-dependent) diabetes mellitus.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Albuminuria; Angiotensin-Converting Enzyme Inhibitor | 1999 |
The effect of selective beta 1-blockade on glucose thresholds for release of counterregulatory hormones and symptoms in insulin-dependent diabetes mellitus.
Topics: Adrenergic beta-Antagonists; Adult; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 1; Differ | 1992 |
Effects of metoprolol on the counter-regulation and recognition of prolonged hypoglycemia in insulin-dependent diabetics.
Topics: Adult; Blood Pressure; Diabetes Mellitus, Type 1; Female; Heart Rate; Hormones; Humans; Hypoglycemia | 1987 |
7 other studies available for metoprolol and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Adrenergic blockade and hypoglycaemia.
Topics: Adrenergic beta-Antagonists; Blood Glucose; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Glucag | 1983 |
The adrenergic contribution to glucose counterregulation in type I diabetes mellitus. Dependency on A-cell function and mediation through beta 2-adrenergic receptors.
Topics: Adolescent; Adult; Blood Glucose; Diabetes Mellitus, Type 1; Hemodynamics; Humans; Insulin; Metoprol | 1983 |
Different effects of the beta-adrenoceptor antagonists celiprolol and metoprolol on vascular structure and function in long-term type I diabetic rats.
Topics: Adrenergic beta-Antagonists; Animals; Blood Chemical Analysis; Blood Vessels; Celiprolol; Cells, Cul | 1999 |
On glomerular structural alterations in type-1 diabetes. Companions of early diabetic glomerulopathy.
Topics: Adult; Albuminuria; Capillaries; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Enalapril; Extra | 2001 |
The juxtaglomerular apparatus in young type-1 diabetic patients with microalbuminuria. Effect of antihypertensive treatment.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Albuminuria; Angiotensin-Converting Enzyme Inhibitor | 2001 |
ACE-inhibition and renoprotection in early diabetic nephropathy. Response to enalapril acutely and in long-term combination with conventional antihypertensive treatment.
Topics: Adult; Albuminuria; Blood Pressure; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Drug Therapy, | 1991 |
Metoprolol and albumin excretion in diabetes.
Topics: Adult; Albuminuria; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Humans; Male; Metoprolol; Mid | 1986 |