Page last updated: 2024-10-31
metoprolol and Decreased Muscle Tone
metoprolol has been researched along with Decreased Muscle Tone in 1 studies
Metoprolol: A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
metoprolol : A propanolamine that is 1-(propan-2-ylamino)propan-2-ol substituted by a 4-(2-methoxyethyl)phenoxy group at position 1.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|
| " The authors hypothesized that nebivolol, a selective β1 -antagonist that stimulates nitric oxide (NO), will improve endothelial function in AAs with hypertension when compared with metoprolol." | 5.22 | Nitric Oxide Contributes to Vasomotor Tone in Hypertensive African Americans Treated With Nebivolol and Metoprolol. ( Hayek, SS; Kavtaradze, N; Lefer, DJ; Menon, V; Neuman, RB; Polhemus, D; Poole, JC; Quyyumi, AA; Rahman, A; Veledar, E, 2016) |
Research
Studies (1)
| Timeframe | Studies, this research(%) | All Research% |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|
| Neuman, RB | 1 |
| Hayek, SS | 1 |
| Poole, JC | 1 |
| Rahman, A | 1 |
| Menon, V | 1 |
| Kavtaradze, N | 1 |
| Polhemus, D | 1 |
| Veledar, E | 1 |
| Lefer, DJ | 1 |
| Quyyumi, AA | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status |
|---|
| The Effect of Nebivolol on Endothelial Dysfunction in African Americans With Hypertension[NCT01049009] | Phase 4 | 91 participants (Actual) | Interventional | 2009-12-31 | Completed |
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Trial Outcomes
Endothelial Function Measured by Forearm Blood Flow (FBF) at 12 Weeks
Forearm blood flow measured by venous occlusion plethysmography at rest, after administration of N(G)-monomethyl-L-arginine (L-NMMA) and tetraethylammonium chloride (TEA), after administration of L-NMMA, TEA, and acetylcholine, and after administration of L-NMMA, TEA, and exercise. Unit of Measure refers to volume of blood (mL) per 100 mL of forearm tissue per minute. (NCT01049009)
Timeframe: 12 weeks
| Intervention | mL/100 mL/min (Mean) |
|---|
| At rest | L-NMMA+TEA | L-NMMA+TEA+ACh | L-NMMA+TEA+exercise |
|---|
| Metoprolol XL/Nebivolol | 2.679 | 2.221 | 7.562 | 11.574 |
,| Nebivolol/Metoprolol XL | 2.739 | 1.963 | 5.376 | 7.377 |
Endothelial Function Measured by Forearm Blood Flow (FBF) at 24 Weeks
Forearm blood flow measured by venous occlusion plethysmography at rest, after administration of N(G)-monomethyl-L-arginine (L-NMMA) and tetraethylammonium chloride (TEA), after administration of L-NMMA, TEA, and acetylcholine, and after administration of L-NMMA, TEA, and exercise. Unit of Measure refers to volume of blood (mL) per 100 mL of forearm tissue per minute. (NCT01049009)
Timeframe: 24 weeks
| Intervention | mL/100 mL/min (Mean) |
|---|
| At rest | L-NMMA+TEA | L-NMMA+TEA+ACh | L-NMMA+TEA+exercise |
|---|
| Metoprolol XL/Nebivolol | 2.968 | 2.287 | 7.534 | 10.395 |
,| Nebivolol/Metoprolol XL | 3.066 | 2.457 | 7.158 | 9.589 |
Trials
1 trial available for metoprolol and Decreased Muscle Tone