Page last updated: 2024-10-31

metoprolol and Cardiomyopathies

metoprolol has been researched along with Cardiomyopathies in 34 studies

Metoprolol: A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
metoprolol : A propanolamine that is 1-(propan-2-ylamino)propan-2-ol substituted by a 4-(2-methoxyethyl)phenoxy group at position 1.

Cardiomyopathies: A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).

Research Excerpts

ExcerptRelevanceReference
"To focus on evaluating the clinical influence of metoprolol on sepsis-induced cardiomyopathy (SICM)."8.31The influence of metoprolol in patients with sepsis-induced cardiomyopathy: A retrospective study. ( Chen, Y; Li, L; Lu, J; Ning, W; Zhu, J, 2023)
"Relative effectiveness of carvedilol and metoprolol succinate has never been compared in patients with heart failure (HF)."7.78Carvedilol or sustained-release metoprolol for congestive heart failure: a comparative effectiveness analysis. ( Aggarwal, V; Shore, S; Zolty, R, 2012)
" Secondary: changes of a) LV-FS from baseline, b) blood pressure, c), heart rate and autonomic function in ECG and Holter-ECG, e) cardiac biomarkers and neurohumeral serum parameters, f) quality of life, and g) adverse events."6.90Effect and safety of treatment with ACE-inhibitor Enalapril and β-blocker metoprolol on the onset of left ventricular dysfunction in Duchenne muscular dystrophy - a randomized, double-blind, placebo-controlled trial. ( Dittrich, S; Ebinger, F; Graf, E; Heilmann, A; Khalil, M; Kirschner, J; Korenke, C; Lange, M; Motz, R; Müller-Felber, W; Neudorf, U; Pattathu, J; Pozza, RD; Schara, U; Schröder, R; Stiller, B; Trollmann, R; von Au, K; von der Hagen, M; Weiss, K; Wiechmann, N; Wilichowski, E, 2019)
"To focus on evaluating the clinical influence of metoprolol on sepsis-induced cardiomyopathy (SICM)."4.31The influence of metoprolol in patients with sepsis-induced cardiomyopathy: A retrospective study. ( Chen, Y; Li, L; Lu, J; Ning, W; Zhu, J, 2023)
"Background Whether chronic obstructive sleep apnea ( OSA ) could promote epicardial adipose tissue ( EAT ) secretion of profibrotic adipokines, and thereby contribute to atrial fibrosis, and the potential therapeutic effects of metoprolol remain unknown."3.91Metoprolol Inhibits Profibrotic Remodeling of Epicardial Adipose Tissue in a Canine Model of Chronic Obstructive Sleep Apnea. ( Dai, H; Gong, Y; Han, Y; Li, T; Li, Y; Sheng, L; Sun, L; Xu, J; Yin, S; Yuan, Y; Zhang, Y, 2019)
"Relative effectiveness of carvedilol and metoprolol succinate has never been compared in patients with heart failure (HF)."3.78Carvedilol or sustained-release metoprolol for congestive heart failure: a comparative effectiveness analysis. ( Aggarwal, V; Shore, S; Zolty, R, 2012)
"The use of beta-blocking drugs for dilated cardiomyopathy (DCM), however, is currently investigational."3.76Treatment of cardiac myopathies with beta blockers. What do we know, where do we go from here? ( Anderson, JL, 1988)
" Secondary: changes of a) LV-FS from baseline, b) blood pressure, c), heart rate and autonomic function in ECG and Holter-ECG, e) cardiac biomarkers and neurohumeral serum parameters, f) quality of life, and g) adverse events."2.90Effect and safety of treatment with ACE-inhibitor Enalapril and β-blocker metoprolol on the onset of left ventricular dysfunction in Duchenne muscular dystrophy - a randomized, double-blind, placebo-controlled trial. ( Dittrich, S; Ebinger, F; Graf, E; Heilmann, A; Khalil, M; Kirschner, J; Korenke, C; Lange, M; Motz, R; Müller-Felber, W; Neudorf, U; Pattathu, J; Pozza, RD; Schara, U; Schröder, R; Stiller, B; Trollmann, R; von Au, K; von der Hagen, M; Weiss, K; Wiechmann, N; Wilichowski, E, 2019)
"Most patients with Duchenne muscular dystrophy (DMD) will develop cardiomyopathy; however, the evidence for prophylactic treatment of children with cardiac medications is limited."1.42Absence of Cardiac Benefit with Early Combination ACE Inhibitor and Beta Blocker Treatment in mdx Mice. ( Blain, A; Blamire, AM; Greally, E; Laval, SH; MacGowan, GA; Straub, VW, 2015)
"With metoprolol there was an increase in right ventricular end-diastolic and end-systolic volumes."1.39Beta-blockers, left and right ventricular function, and in-vivo calcium influx in muscular dystrophy cardiomyopathy. ( Blain, A; Blamire, A; Greally, E; Laval, S; MacGowan, GA; Straub, V, 2013)
"Hypertension is associated with left ventricular hypertrophy (LVH) and diastolic dysfunction."1.35Improvement of cardiac diastolic function by long-term centrally mediated sympathetic inhibition in one-kidney, one-clip hypertensive rabbits. ( Bousquet, PP; Monassier, LJ; Signolet, IL, 2008)

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19903 (8.82)18.7374
1990's4 (11.76)18.2507
2000's9 (26.47)29.6817
2010's12 (35.29)24.3611
2020's6 (17.65)2.80

Authors

AuthorsStudies
Chen, C1
Tian, J1
He, Z1
Xiong, W1
He, Y1
Liu, S1
Ning, W1
Chen, Y1
Lu, J1
Zhu, J1
Li, L1
Rajendram, R1
AlDhahri, F1
Mahmood, N1
Kharal, M1
Juusela, A1
Nazir, M1
Gimovsky, M1
Eijgenraam, TR1
Boukens, BJ1
Boogerd, CJ1
Schouten, EM1
van de Kolk, CWA1
Stege, NM1
Te Rijdt, WP1
Hoorntje, ET1
van der Zwaag, PA1
van Rooij, E1
van Tintelen, JP1
van den Berg, MP1
van der Meer, P1
van der Velden, J1
Silljé, HHW1
de Boer, RA1
Padkins, MR1
Bell, MR1
Sönmez, BM1
İşcanlı, MD1
Durdu, T1
Kala, İ1
Tarhan, N1
Uysal, P1
Silvestre, OM1
Farias, AQ1
Ramos, DS1
Furtado, MS1
Rodrigues, AC1
Ximenes, RO1
de Campos Mazo, DF1
Yoshimura Zitelli, PM1
Diniz, MA1
Andrade, JL1
Strunz, C1
Friedmann, AA1
Lee, SS1
Carrilho, FJ1
D'Albuquerque, LAC1
Bacal, F1
Erolu, E1
Akalın, F1
Saylan Çevik, B1
Yücelten, D1
Chamorro-Pareja, N1
Marin-Acevedo, JA1
Chirilă, RM1
Dai, H1
Yuan, Y1
Yin, S1
Zhang, Y1
Han, Y1
Sun, L1
Li, T1
Xu, J1
Sheng, L1
Gong, Y1
Li, Y1
Dittrich, S1
Graf, E1
Trollmann, R1
Neudorf, U1
Schara, U1
Heilmann, A1
von der Hagen, M1
Stiller, B1
Kirschner, J1
Pozza, RD1
Müller-Felber, W1
Weiss, K1
von Au, K1
Khalil, M1
Motz, R1
Korenke, C1
Lange, M1
Wilichowski, E1
Pattathu, J1
Ebinger, F1
Wiechmann, N1
Schröder, R1
Blain, A2
Greally, E2
Laval, S1
Blamire, A1
Straub, V1
MacGowan, GA2
Laval, SH1
Blamire, AM1
Straub, VW1
Ge, H1
Li, X1
Liu, H1
Jiang, H1
Nazeri, A1
Elayda, MA1
Segura, AM1
Stainback, RF1
Nathan, J1
Lee, VV1
Bove, C1
Sampaio, L1
Grace, B1
Massumi, A1
Razavi, M1
Schmittinger, CA1
Dünser, MW1
Haller, M1
Ulmer, H1
Luckner, G1
Torgersen, C1
Jochberger, S1
Hasibeder, WR1
Seeland, U1
Schäffer, A1
Selejan, S1
Hohl, M1
Reil, JC1
Müller, P1
Rosenkranz, S1
Böhm, M1
He, L1
Xiao, J1
Fu, H1
Du, G1
Xiao, X1
Zhang, C1
Gu, Y1
Ma, Y1
Shore, S1
Aggarwal, V1
Zolty, R1
Sibal, L1
Jovanovic, A1
Agarwal, SC1
Peaston, RT1
James, RA1
Lennard, TW1
Bliss, R1
Batchelor, A1
Perros, P1
Simões, MV1
Marin-Neto, JA1
Romano, MM1
O'Connell, JL1
de Santi, GL1
Maciel, BC1
Signolet, IL1
Bousquet, PP1
Monassier, LJ1
Liu, J1
Mao, W1
Iwai, C1
Fukuoka, S1
Vulapalli, R1
Huang, H1
Wang, T1
Sharma, VK1
Sheu, SS1
Fu, M1
Liang, CS1
Okamoto, M1
Hashimoto, M1
Sueda, T1
Munemori, M1
Yamada, T1
McMullan, MR1
Moore, CK1
O'Connell, JB1
Andersson, B1
Lomsky, M1
Waagstein, F1
Witte, K1
Kinzler, N1
Schnecko, A1
Olbrich, HG1
Lemmer, B1
Noori, A1
Lindenfeld, J1
Wolfel, E1
Ferguson, D1
Bristow, MR1
Lowes, BD1
Beanlands, RS1
Nahmias, C1
Gordon, E1
Coates, G1
deKemp, R1
Firnau, G1
Fallen, E1
Bennett, SK1
Smith, MF1
Gottlieb, SS1
Fisher, ML1
Bacharach, SL1
Dilsizian, V1
Kolin, A2
Brezina, A2
Lewis, AJ2
Norris, JW2
Anderson, JL1
Kellen, JA1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in Hypertension[NCT05593055]Phase 475 participants (Anticipated)Interventional2023-08-25Recruiting
Effects of Long Term Adaptive Servo Ventilation Therapy on Myocardial Energetics and Sympathetic Nerve Function in Heart Failure and Sleep Apnea. The AMEND Sub-study[NCT02116140]60 participants (Anticipated)Interventional2012-07-31Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for metoprolol and Cardiomyopathies

ArticleYear
33-Year-Old Woman With Postpartum Acute Shortness of Breath.
    Mayo Clinic proceedings, 2020, Volume: 95, Issue:9

    Topics: Adrenergic beta-1 Receptor Antagonists; Cardiomyopathies; Cesarean Section; Dyspnea; Female; Humans;

2020
Cardiac sarcoidosis: Case presentation and Review of the literature.
    Romanian journal of internal medicine = Revue roumaine de medecine interne, 2019, Mar-01, Volume: 57, Issue:1

    Topics: Cardiomyopathies; Cardiovascular Agents; Drug Therapy, Combination; Female; Humans; Immunosuppressiv

2019
Treatment of cardiac myopathies with beta blockers. What do we know, where do we go from here?
    Postgraduate medicine, 1988, Feb-29, Volume: Spec No

    Topics: Adrenergic beta-Antagonists; Cardiomyopathies; Cardiomyopathy, Dilated; Cardiomyopathy, Hypertrophic

1988

Trials

4 trials available for metoprolol and Cardiomyopathies

ArticleYear
β-Blocker therapy for cirrhotic cardiomyopathy: a randomized-controlled trial.
    European journal of gastroenterology & hepatology, 2018, Volume: 30, Issue:8

    Topics: Adolescent; Adrenergic beta-1 Receptor Antagonists; Adult; Biomarkers; Brazil; Cardiac Output; Cardi

2018
Effect and safety of treatment with ACE-inhibitor Enalapril and β-blocker metoprolol on the onset of left ventricular dysfunction in Duchenne muscular dystrophy - a randomized, double-blind, placebo-controlled trial.
    Orphanet journal of rare diseases, 2019, 05-10, Volume: 14, Issue:1

    Topics: Adolescent; Adrenergic beta-1 Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Cardio

2019
The effects of beta(1)-blockade on oxidative metabolism and the metabolic cost of ventricular work in patients with left ventricular dysfunction: A double-blind, placebo-controlled, positron-emission tomography study.
    Circulation, 2000, Oct-24, Volume: 102, Issue:17

    Topics: Acetates; Adrenergic beta-Antagonists; Aged; Blood Pressure; Carbon Radioisotopes; Cardiomyopathies;

2000
The effects of beta(1)-blockade on oxidative metabolism and the metabolic cost of ventricular work in patients with left ventricular dysfunction: A double-blind, placebo-controlled, positron-emission tomography study.
    Circulation, 2000, Oct-24, Volume: 102, Issue:17

    Topics: Acetates; Adrenergic beta-Antagonists; Aged; Blood Pressure; Carbon Radioisotopes; Cardiomyopathies;

2000
The effects of beta(1)-blockade on oxidative metabolism and the metabolic cost of ventricular work in patients with left ventricular dysfunction: A double-blind, placebo-controlled, positron-emission tomography study.
    Circulation, 2000, Oct-24, Volume: 102, Issue:17

    Topics: Acetates; Adrenergic beta-Antagonists; Aged; Blood Pressure; Carbon Radioisotopes; Cardiomyopathies;

2000
The effects of beta(1)-blockade on oxidative metabolism and the metabolic cost of ventricular work in patients with left ventricular dysfunction: A double-blind, placebo-controlled, positron-emission tomography study.
    Circulation, 2000, Oct-24, Volume: 102, Issue:17

    Topics: Acetates; Adrenergic beta-Antagonists; Aged; Blood Pressure; Carbon Radioisotopes; Cardiomyopathies;

2000
Treatment of cardiac myopathies with beta blockers. What do we know, where do we go from here?
    Postgraduate medicine, 1988, Feb-29, Volume: Spec No

    Topics: Adrenergic beta-Antagonists; Cardiomyopathies; Cardiomyopathy, Dilated; Cardiomyopathy, Hypertrophic

1988

Other Studies

28 other studies available for metoprolol and Cardiomyopathies

ArticleYear
Identified Three Interferon Induced Proteins as Novel Biomarkers of Human Ischemic Cardiomyopathy.
    International journal of molecular sciences, 2021, Dec-04, Volume: 22, Issue:23

    Topics: Animals; Apoptosis Regulatory Proteins; Biomarkers; Cardiomyopathies; Disease Models, Animal; Gene R

2021
The influence of metoprolol in patients with sepsis-induced cardiomyopathy: A retrospective study.
    Saudi medical journal, 2023, Volume: 44, Issue:10

    Topics: Cardiomyopathies; Humans; Metoprolol; Norepinephrine; Retrospective Studies; Sepsis

2023
The use of ivabradine in a patient with inappropriate sinus tachycardia and cardiomyopathy due to limb girdle muscular dystrophy type 2I.
    BMJ case reports, 2020, Jan-21, Volume: 13, Issue:1

    Topics: Anti-Arrhythmia Agents; Cardiomyopathies; Cardiovascular Agents; Diagnosis, Differential; Female; Hu

2020
Two cases of coronavirus 2019-related cardiomyopathy in pregnancy.
    American journal of obstetrics & gynecology MFM, 2020, Volume: 2, Issue:2

    Topics: Adult; Anti-Arrhythmia Agents; Antibodies, Monoclonal, Humanized; Anticonvulsants; Blood Gas Analysi

2020
The phospholamban p.(Arg14del) pathogenic variant leads to cardiomyopathy with heart failure and is unreponsive to standard heart failure therapy.
    Scientific reports, 2020, 06-17, Volume: 10, Issue:1

    Topics: Animals; Calcium-Binding Proteins; Cardiomyopathies; Eplerenone; Heart Failure; Metoprolol; Mice; Mu

2020
What's going wrong with this postpartum woman?
    The American journal of emergency medicine, 2018, Volume: 36, Issue:4

    Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Anticoagulants; Cardiomyopathies; Cardiovascular Agen

2018
Arrhythmogenic right ventricular dysplasia, cutaneous manifestations and desmoplakin mutation: Carvajal syndrome.
    Pediatrics international : official journal of the Japan Pediatric Society, 2018, Volume: 60, Issue:10

    Topics: Adrenergic beta-1 Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Arrhythmogenic Rig

2018
Metoprolol Inhibits Profibrotic Remodeling of Epicardial Adipose Tissue in a Canine Model of Chronic Obstructive Sleep Apnea.
    Journal of the American Heart Association, 2019, 02-05, Volume: 8, Issue:3

    Topics: Adipokines; Adipose Tissue; Animals; Cardiomyopathies; Chronic Disease; Disease Models, Animal; Dogs

2019
Beta-blockers, left and right ventricular function, and in-vivo calcium influx in muscular dystrophy cardiomyopathy.
    PloS one, 2013, Volume: 8, Issue:2

    Topics: Adrenergic beta-Antagonists; Animals; Body Weight; Calcium; Cardiomyopathies; Ion Transport; Male; M

2013
Absence of Cardiac Benefit with Early Combination ACE Inhibitor and Beta Blocker Treatment in mdx Mice.
    Journal of cardiovascular translational research, 2015, Volume: 8, Issue:3

    Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Calcium; Captopril;

2015
Predictors of Pharmacological Therapy of Ectopic Atrial Tachycardia in Children.
    Pediatric cardiology, 2017, Volume: 38, Issue:2

    Topics: Amiodarone; Anti-Arrhythmia Agents; Cardiomyopathies; Child; Child, Preschool; China; Drug Therapy,

2017
Comparative Efficacy of Nebivolol and Metoprolol to Prevent Tachycardia-Induced Cardiomyopathy in a Porcine Model.
    Texas Heart Institute journal, 2016, Volume: 43, Issue:6

    Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Cardiac Pacing, Artificial; Cardiomyopathies; Disea

2016
Combined milrinone and enteral metoprolol therapy in patients with septic myocardial depression.
    Critical care (London, England), 2008, Volume: 12, Issue:4

    Topics: Aged; Aged, 80 and over; Cardiomyopathies; Drug Therapy, Combination; Female; Humans; Male; Metoprol

2008
Effects of AT1- and beta-adrenergic receptor antagonists on TGF-beta1-induced fibrosis in transgenic mice.
    European journal of clinical investigation, 2009, Volume: 39, Issue:10

    Topics: Animals; Benzimidazoles; Benzoates; Cardiomyopathies; Collagen; Metoprolol; Mice; Mice, Transgenic;

2009
Effect of oxidative stress on ventricular arrhythmia in rabbits with adriamycin-induced cardiomyopathy.
    Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2012, Volume: 32, Issue:3

    Topics: Animals; Anti-Arrhythmia Agents; Antibiotics, Antineoplastic; Carbazoles; Cardiomyopathies; Carvedil

2012
Carvedilol or sustained-release metoprolol for congestive heart failure: a comparative effectiveness analysis.
    Journal of cardiac failure, 2012, Volume: 18, Issue:12

    Topics: Adrenergic beta-Antagonists; Carbazoles; Cardiomyopathies; Carvedilol; Cohort Studies; Delayed-Actio

2012
Phaeochromocytomas presenting as acute crises after beta blockade therapy.
    Clinical endocrinology, 2006, Volume: 65, Issue:2

    Topics: Acute Disease; Adrenal Gland Neoplasms; Adrenalectomy; Adrenergic beta-Antagonists; Adult; Cardiomyo

2006
Transient left ventricular dysfunction due to stress-induced cardiomyopathy.
    Arquivos brasileiros de cardiologia, 2007, Volume: 89, Issue:4

    Topics: Acute Coronary Syndrome; Adrenergic beta-Antagonists; Aged; Angiotensin II Type 1 Receptor Blockers;

2007
Improvement of cardiac diastolic function by long-term centrally mediated sympathetic inhibition in one-kidney, one-clip hypertensive rabbits.
    American journal of hypertension, 2008, Volume: 21, Issue:1

    Topics: Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Cardiomyopathies; Dia

2008
Adoptive passive transfer of rabbit beta1-adrenoceptor peptide immune cardiomyopathy into the Rag2-/- mouse: participation of the ER stress.
    Journal of molecular and cellular cardiology, 2008, Volume: 44, Issue:2

    Topics: Adoptive Transfer; Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cardiomyo

2008
Polymorphic ventricular tachycardia with cardiac sarcoidosis: treatment with low-dose metoprolol and cibenzoline.
    Internal medicine (Tokyo, Japan), 1994, Volume: 33, Issue:5

    Topics: Adult; Anti-Arrhythmia Agents; Cardiomyopathies; Drug Therapy, Combination; Electrocardiography; Fem

1994
Diagnosis and management of peripartum cardiomyopathy.
    Hospital practice (Office ed.), 1993, Nov-15, Volume: 28, Issue:11

    Topics: Adult; Algorithms; Captopril; Cardiomyopathies; Diagnosis, Differential; Digoxin; Drug Administratio

1993
The link between acute haemodynamic adrenergic beta-blockade and long-term effects in patients with heart failure. A study on diastolic function, heart rate and myocardial metabolism following intravenous metoprolol.
    European heart journal, 1993, Volume: 14, Issue:10

    Topics: Adolescent; Adult; Aged; Cardiac Pacing, Artificial; Cardiomyopathies; Diastole; Dose-Response Relat

1993
Effects of beta-adrenoceptor blockade on beta-adrenergic signal transduction in cardiomyopathic hamster (BIO 8262) hearts.
    European journal of pharmacology, 1997, Sep-10, Volume: 334, Issue:2-3

    Topics: 5'-Nucleotidase; Adenylyl Cyclases; Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-2 Recept

1997
Beta-blockade in adriamycin-induced cardiomyopathy.
    Journal of cardiac failure, 2000, Volume: 6, Issue:2

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Antineoplastic Agents; Carbazoles; Cardiomyopathies; Cardi

2000
Effect of metoprolol on absolute myocardial blood flow in patients with heart failure secondary to ischemic or nonischemic cardiomyopathy.
    The American journal of cardiology, 2002, Jun-15, Volume: 89, Issue:12

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Angiography; Cardiac Output; Cardiomyopathies; Chi-Square

2002
Quantitative evaluation of myocardial injury induced by acute cerebral ischaemia and its prevention by beta 1-adrenergic blockade. An ultrastructural morphometry study.
    British journal of experimental pathology, 1989, Volume: 70, Issue:6

    Topics: Acute Disease; Animals; Brain Ischemia; Cardiomyopathies; Gerbillinae; Lipid Metabolism; Male; Metop

1989
Reversible myocardial damage in gerbil brain ischaemia and its prevention by beta-adrenergic blockade.
    British journal of experimental pathology, 1988, Volume: 69, Issue:5

    Topics: Animals; Brain; Brain Ischemia; Cardiomyopathies; Carotid Arteries; Creatine Kinase; Gerbillinae; Li

1988