metoprolol has been researched along with Cardiomegaly in 52 studies
Metoprolol: A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
metoprolol : A propanolamine that is 1-(propan-2-ylamino)propan-2-ol substituted by a 4-(2-methoxyethyl)phenoxy group at position 1.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "During the intervening years since metoprolol was first reviewed in the Journal (1977), it has become widely used in the treatment of mild to moderate hypertension and angina pectoris." | 8.77 | Metoprolol. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in hypertension, ischaemic heart disease and related cardiovascular disorders. ( Benfield, P; Brogden, RN; Clissold, SP, 1986) |
| " More importantly, ruboxistaurin prevented death in wild-type mice throughout 10 weeks of pressure-overload stimulation, reduced ventricular dilation, enhanced ventricular performance, reduced fibrosis, and reduced pulmonary edema comparable to or better than metoprolol treatment." | 7.75 | Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach. ( Chen, X; Houser, SR; Kranias, EG; Leitges, M; Liu, Q; Lorenz, JN; Macdonnell, SM; Molkentin, JD, 2009) |
| "A recent clinical study has shown that carvedilol has a significantly more favorable effect than metoprolol on survival rate in patients with heart failure." | 7.74 | Comparison of pharmacodynamics between carvedilol and metoprolol in rats with isoproterenol-induced cardiac hypertrophy: effects of carvedilol enantiomers. ( Asari, K; Hanada, K; Kawana, J; Mita, M; Ogata, H; Saito, M, 2008) |
| "Cocaine increases adult cardiomyocyte protein content by protein kinase Calpha-dependent mechanisms, and this process can contribute to the cardiac hypertrophy and cardiomyopathy that results from chronic cocaine use." | 7.72 | Cocaine produces cardiac hypertrophy by protein kinase C dependent mechanisms. ( Henning, RJ; Li, Y, 2003) |
| "Using ultrasound techniques, parameters of left ventricular systolic and diastolic function were assessed in 23 patients with degree I-II essential hypertension treated with metoprolol." | 7.68 | The effect of metoprolol on left ventricular systolic and diastolic function in essential hypertension. ( Hradec, J; Král, J; Petrásek, J, 1991) |
| "Twenty patients whose systemic hypertension was not controlled with chronic beta-blocker therapy were studied to evaluate the acute (first dose), short-term (4 weeks) and chronic (6 to 12 months) effects of the calcium antagonist felodipine on blood pressure (BP), left ventricular (LV) anatomy and function and on plasma norepinephrine." | 5.07 | Antihypertensive effect of felodipine associated with persistent sympathetic activation and minimal regression of left ventricular hypertrophy. ( Holliwell, DL; Leenen, FH, 1992) |
| "We compared the effects of weight reduction, metoprolol, and placebo on M-mode echocardiographic measurements of the thickness and mass of the left ventricular wall in a 21-week, randomized controlled trial that enrolled 41 young, overweight patients with hypertension." | 5.06 | The effect of weight reduction on left ventricular mass. A randomized controlled trial in young, overweight hypertensive patients. ( Macdonald, GJ; MacMahon, SW; Wilcken, DE, 1986) |
| "Mortality was analysed in relation to clinical and radiological signs of left ventricular failure in a double-blind randomized comparison of 154 post-myocardial infarction patients assigned to metoprolol (100 mg b." | 5.06 | Effect of metoprolol in postinfarction patients with increased heart size. ( Olsson, G; Rehnqvist, N, 1986) |
| "Weight reduction was compared with metoprolol (200 mg daily) in a randomized placebo-controlled trial of first-line treatment of mild hypertension (diastolic blood pressure 90-109 mm Hg) in 56 overweight patients aged under 55 years." | 5.06 | Treatment of high blood pressure in overweight patients. ( Macdonald, G; MacMahon, S, 1987) |
| "During the intervening years since metoprolol was first reviewed in the Journal (1977), it has become widely used in the treatment of mild to moderate hypertension and angina pectoris." | 4.77 | Metoprolol. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in hypertension, ischaemic heart disease and related cardiovascular disorders. ( Benfield, P; Brogden, RN; Clissold, SP, 1986) |
| " The aim of this study was to investigate whether nebivolol has additional effects on β-adrenoceptor-mediated functional responses along with morphologic and molecular determinants of cardiac hypertrophy compared with those of metoprolol, a selective β1-adrenoceptor blocker." | 3.79 | Nebivolol prevents desensitization of β-adrenoceptor signaling and induction of cardiac hypertrophy in response to isoprenaline beyond β1-adrenoceptor blockage. ( Altan, VM; Arioglu-Inan, E; Balligand, JL; Esfahani, H; Kayki-Mutlu, G; Ozakca, I; Ozcelikay, AT, 2013) |
| " More importantly, ruboxistaurin prevented death in wild-type mice throughout 10 weeks of pressure-overload stimulation, reduced ventricular dilation, enhanced ventricular performance, reduced fibrosis, and reduced pulmonary edema comparable to or better than metoprolol treatment." | 3.75 | Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach. ( Chen, X; Houser, SR; Kranias, EG; Leitges, M; Liu, Q; Lorenz, JN; Macdonnell, SM; Molkentin, JD, 2009) |
| "A recent clinical study has shown that carvedilol has a significantly more favorable effect than metoprolol on survival rate in patients with heart failure." | 3.74 | Comparison of pharmacodynamics between carvedilol and metoprolol in rats with isoproterenol-induced cardiac hypertrophy: effects of carvedilol enantiomers. ( Asari, K; Hanada, K; Kawana, J; Mita, M; Ogata, H; Saito, M, 2008) |
| "Cocaine increases adult cardiomyocyte protein content by protein kinase Calpha-dependent mechanisms, and this process can contribute to the cardiac hypertrophy and cardiomyopathy that results from chronic cocaine use." | 3.72 | Cocaine produces cardiac hypertrophy by protein kinase C dependent mechanisms. ( Henning, RJ; Li, Y, 2003) |
| "Using ultrasound techniques, parameters of left ventricular systolic and diastolic function were assessed in 23 patients with degree I-II essential hypertension treated with metoprolol." | 3.68 | The effect of metoprolol on left ventricular systolic and diastolic function in essential hypertension. ( Hradec, J; Král, J; Petrásek, J, 1991) |
| "7 years), with previously untreated essential hypertension and echocardiographically proven left-ventricular hypertrophy, received metoprolol 200 mg daily over a period of 12." | 3.67 | [Regression of myocardial hypertrophy in hypertensives on chronic beta-receptor block]. ( Behr, M; Franz, IW; Ketelhut, R; Wiewel, D, 1986) |
| " D-Propranolol and metoprolol did not reduce hypoxia-induced right ventricular hypertrophy or polycythemia." | 3.66 | Chronic propranolol treatment blunts right ventricular hypertrophy in rats at high altitude. ( McMurtry, IF; Reeves, JT; Voelkel, NF, 1980) |
| "Metoprolol is a cardioprotective anti-hypertensive agent." | 1.48 | Modulation of cardiac stem cell characteristics by metoprolol in hypertensive heart disease. ( Nair, RR; Potnuri, AG; Saheera, S, 2018) |
| "While the expression patterns of cardiac hypertrophy-related genes have been well documented and widely used as markers for hypertrophy, recent research has revealed uncoupling of hypertrophy-related gene profiles and hypertrophic growth." | 1.34 | Divergence of hypertrophic growth and fetal gene profile: the influence of beta-blockers. ( Du, XJ, 2007) |
| "Metoprolol treatment produced a slight but significant reduction in serum glucose levels with elevation in serum insulin levels, while atenolol produced a slight increase in glucose levels but no effect on insulin levels." | 1.34 | Comparative evaluation of atenolol and metoprolol on cardiovascular complications associated with streptozotocin-induced diabetic rats. ( Bhadada, SV; Goyal, RK, 2007) |
| " Chronic administration of metoprolol, a beta-blocking agent, induced further increase in left ventricular volume and mass without changing left ventricular function and myosin isozyme pattern." | 1.28 | Cardiac adaptation and its limitation in an experimental model of congestive heart failure. ( Iizuka, M; Momomura, S; Ohtani, Y; Serizawa, T; Sugimoto, T; Sugiura, S; Yamashita, H, 1992) |
| "Metoprolol was given in doses of 100 to 400 mg/day (average dose, 167 mg/day in two divided doses) and significantly reduced both casual, office blood pressure (150/101 to 130/86 mm Hg, p less than 0." | 1.28 | Regression of left ventricular mass is accompanied by improvement in rapid left ventricular filling following antihypertensive therapy with metoprolol. ( Karimeddini, MK; Schulman, P; Smith, VE; White, WB, 1989) |
| "Metoprolol-treated SHR showed a trend toward higher capillary numerical densities consistent with their attenuation of hypertrophy." | 1.28 | Sympathetic nerves modify mitochondrial and capillary growth in normotensive and hypertensive rats. ( Tomanek, RJ, 1989) |
| " Metoprolol, a selective beta-1 receptor antagonist, significantly inhibited the glandular enlargement induced by dobutamine or isoproterenol and produced a parallel shift in the isoproterenol dose-response curve." | 1.26 | Adrenergic beta receptors mediating submandibular salivary gland hypertrophy in the rat. ( Brenner, GM; Wulf, RG, 1981) |
| "Metoprolol-treated and untreated rats were subjected to the same treadmill running program for 12 weeks." | 1.26 | Effect of beta-adrenergic receptor blockade on development of training-induced bradycardia in rats. ( Nylander, E, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (48.08) | 18.7374 |
| 1990's | 12 (23.08) | 18.2507 |
| 2000's | 9 (17.31) | 29.6817 |
| 2010's | 6 (11.54) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Saheera, S | 2 |
| Potnuri, AG | 2 |
| Nair, RR | 2 |
| Allakonda, L | 1 |
| Appavoo, A | 1 |
| Ozakca, I | 1 |
| Arioglu-Inan, E | 1 |
| Esfahani, H | 1 |
| Altan, VM | 1 |
| Balligand, JL | 1 |
| Kayki-Mutlu, G | 1 |
| Ozcelikay, AT | 1 |
| Hanada, K | 1 |
| Asari, K | 1 |
| Saito, M | 1 |
| Kawana, J | 1 |
| Mita, M | 1 |
| Ogata, H | 1 |
| Liu, Q | 1 |
| Chen, X | 1 |
| Macdonnell, SM | 1 |
| Kranias, EG | 1 |
| Lorenz, JN | 1 |
| Leitges, M | 1 |
| Houser, SR | 1 |
| Molkentin, JD | 1 |
| Partington, SL | 1 |
| Givertz, MM | 1 |
| Gupta, S | 1 |
| Kwong, RY | 1 |
| Huntgeburth, M | 1 |
| Tiemann, K | 1 |
| Shahverdyan, R | 1 |
| Schlüter, KD | 1 |
| Schreckenberg, R | 1 |
| Gross, ML | 1 |
| Mödersheim, S | 1 |
| Caglayan, E | 1 |
| Müller-Ehmsen, J | 1 |
| Ghanem, A | 1 |
| Vantler, M | 1 |
| Zimmermann, WH | 1 |
| Böhm, M | 1 |
| Rosenkranz, S | 1 |
| Patrizio, M | 1 |
| Musumeci, M | 1 |
| Piccone, A | 1 |
| Raggi, C | 1 |
| Mattei, E | 1 |
| Marano, G | 1 |
| Henning, RJ | 1 |
| Li, Y | 1 |
| Campos, LA | 1 |
| Iliescu, R | 1 |
| Fontes, MA | 1 |
| Schlegel, WP | 1 |
| Bader, M | 1 |
| Baltatu, OC | 1 |
| Perrino, C | 1 |
| Naga Prasad, SV | 1 |
| Mao, L | 1 |
| Noma, T | 1 |
| Yan, Z | 1 |
| Kim, HS | 1 |
| Smithies, O | 1 |
| Rockman, HA | 1 |
| Du, XJ | 1 |
| Bhadada, SV | 1 |
| Goyal, RK | 1 |
| Lampa, E | 1 |
| Rossi, F | 1 |
| Aliperta, A | 1 |
| Giordano, L | 1 |
| Perna, D | 1 |
| Catena, E | 1 |
| Marmo, E | 1 |
| Brenner, GM | 1 |
| Wulf, RG | 1 |
| Nylander, E | 1 |
| Hjalmarson, A | 1 |
| Källfelt, B | 1 |
| Swedberg, K | 1 |
| Waagstein, F | 1 |
| Waldenström, A | 1 |
| Sonaglioni, G | 1 |
| Floris, B | 1 |
| Franchetta, G | 1 |
| Palestini, N | 1 |
| Verdecchia, P | 2 |
| Ikram, H | 1 |
| Fitzpatrick, MA | 1 |
| Ricciardelli, B | 1 |
| De Luca, N | 1 |
| Volpe, M | 1 |
| Veniero, AM | 1 |
| De Simone, A | 1 |
| Cuocolo, A | 1 |
| Rosiello, G | 1 |
| Trimarco, B | 1 |
| Condorelli, M | 1 |
| Corea, L | 1 |
| Bentivoglio, M | 1 |
| Provvidenza, M | 1 |
| Motolese, M | 1 |
| Lundin, SA | 1 |
| Hallbäck-Nordlander, MI | 1 |
| Voelkel, NF | 1 |
| McMurtry, IF | 1 |
| Reeves, JT | 1 |
| Theres, HP | 1 |
| Wagner, KD | 1 |
| Romberg, D | 1 |
| Feig, C | 1 |
| Strube, S | 1 |
| Leiterer, KP | 1 |
| Günther, J | 1 |
| Stangl, K | 1 |
| Baumann, G | 1 |
| Schimke, I | 1 |
| Frolov, VA | 1 |
| Drozdova, GA | 1 |
| Mustyatsa, VF | 1 |
| Rieger, P | 1 |
| Antoni, Z | 1 |
| Kuzovkin, AE | 1 |
| Hopson, JR | 1 |
| Martins, JB | 2 |
| Leenen, FH | 1 |
| Holliwell, DL | 1 |
| Wetzchewald, D | 2 |
| Klaus, D | 2 |
| Garanin, G | 2 |
| Lohr, E | 2 |
| Hoffmann, J | 2 |
| Momomura, S | 1 |
| Yamashita, H | 1 |
| Sugiura, S | 1 |
| Ohtani, Y | 1 |
| Serizawa, T | 1 |
| Iizuka, M | 1 |
| Sugimoto, T | 1 |
| Dellsperger, KC | 2 |
| Clothier, JL | 2 |
| Koyanagi, S | 1 |
| Inou, T | 1 |
| Marcus, ML | 2 |
| Hradec, J | 1 |
| Král, J | 1 |
| Petrásek, J | 1 |
| Strauer, BE | 1 |
| Franz, IW | 4 |
| Tönnesmann, U | 3 |
| Behr, U | 3 |
| Ketelhut, R | 4 |
| Adams, MA | 1 |
| Hirst, M | 1 |
| Kirby, DA | 1 |
| Pinto, JM | 1 |
| Lown, B | 1 |
| White, WB | 1 |
| Schulman, P | 1 |
| Karimeddini, MK | 1 |
| Smith, VE | 1 |
| Nielsen, H | 1 |
| Christensen, HR | 1 |
| Christensen, KL | 1 |
| Baandrup, U | 1 |
| Jespersen, LT | 1 |
| Sirakova, V | 1 |
| Penkov, N | 1 |
| Kaponov, Kh | 1 |
| Tomanek, RJ | 1 |
| Bestetti, RB | 1 |
| Pinto, LZ | 1 |
| Finzi, LA | 1 |
| Secches, AL | 1 |
| Glasser, SP | 1 |
| Koehn, DK | 1 |
| Powell, R | 1 |
| Wiewel, D | 1 |
| Behr, M | 1 |
| Rambausek, M | 1 |
| Ritz, E | 1 |
| Mall, G | 1 |
| Mehls, O | 1 |
| Katus, H | 1 |
| MacMahon, SW | 1 |
| Wilcken, DE | 1 |
| Macdonald, GJ | 1 |
| Benfield, P | 1 |
| Clissold, SP | 1 |
| Brogden, RN | 1 |
| Samuelsson, O | 1 |
| Berglund, G | 1 |
| Elmfeldt, D | 1 |
| Wilhelmsen, L | 1 |
| Wikstrand, J | 1 |
| Olsson, G | 1 |
| Rehnqvist, N | 1 |
| MacMahon, S | 1 |
| Macdonald, G | 1 |
2 reviews available for metoprolol and Cardiomegaly
| Article | Year |
|---|---|
Effects of coronary artery occlusion in animals with hypertension and left ventricular hypertrophy.
Topics: Animals; Arterial Occlusive Diseases; Cardiomegaly; Coronary Vessels; Dogs; Enalapril; Hemodynamics; | 1991 |
Metoprolol. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in hypertension, ischaemic heart disease and related cardiovascular disorders.
Topics: Adult; Age Factors; Aged; Arrhythmias, Cardiac; Cardiomegaly; Coronary Disease; Drug Interactions; D | 1986 |
10 trials available for metoprolol and Cardiomegaly
| Article | Year |
|---|---|
Beta blockade for dilated cardiomyopathy: the evidence against therapeutic benefit.
Topics: Cardiomegaly; Clinical Trials as Topic; Dilatation, Pathologic; Heart Failure; Humans; Metoprolol; P | 1983 |
Antihypertensive effect of felodipine associated with persistent sympathetic activation and minimal regression of left ventricular hypertrophy.
Topics: Adult; Aged; Analysis of Variance; Cardiomegaly; Double-Blind Method; Drug Therapy, Combination; Fel | 1992 |
Regression of left ventricular hypertrophy during long-term antihypertensive treatment--a comparison between felodipine and the combination of felodipine and metoprolol.
Topics: Adult; Analysis of Variance; Blood Pressure; Cardiomegaly; Double-Blind Method; Drug Therapy, Combin | 1992 |
[Regression of left ventricular hypertrophy in hypertensive patients under long-term therapy with antihypertensive agents].
Topics: Acebutolol; Adult; Antihypertensive Agents; Atenolol; Cardiomegaly; Female; Gallopamil; Humans; Hype | 1990 |
[Regression of left heart hypertrophy in hypertensive patients as a result of antihypertensive therapy].
Topics: Acebutolol; Adult; Antihypertensive Agents; Atenolol; Cardiac Output; Cardiac Volume; Cardiomegaly; | 1989 |
Regression of left ventricular hypertrophy in treated hypertensive patients with dilevalol and metoprolol--a double blind randomized study.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Cardiomegaly; Double-Blind Method; Echocardiography; Elect | 1989 |
The effect of weight reduction on left ventricular mass. A randomized controlled trial in young, overweight hypertensive patients.
Topics: Adult; Blood Pressure; Body Weight; Cardiac Volume; Cardiomegaly; Clinical Trials as Topic; Diet, Re | 1986 |
QRS-amplitudes during antihypertensive treatment: a comparison between beta-blocker and thiazide diuretic regimens.
Topics: Adult; Aged; Blood Pressure; Cardiomegaly; Clinical Trials as Topic; Coronary Disease; Electrocardio | 1986 |
Effect of metoprolol in postinfarction patients with increased heart size.
Topics: Cardiomegaly; Clinical Trials as Topic; Double-Blind Method; Female; Follow-Up Studies; Humans; Male | 1986 |
Treatment of high blood pressure in overweight patients.
Topics: Adult; Blood Pressure; Body Weight; Cardiac Volume; Cardiomegaly; Clinical Trials as Topic; Diet, Re | 1987 |
40 other studies available for metoprolol and Cardiomegaly
| Article | Year |
|---|---|
Modulation of cardiac stem cell characteristics by metoprolol in hypertensive heart disease.
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Cardiomegaly; Cell Movement; Cell Proliferatio | 2018 |
Association of histamine with hypertension-induced cardiac remodeling and reduction of hypertrophy with the histamine-2-receptor antagonist famotidine compared with the beta-blocker metoprolol.
Topics: Adrenergic beta-1 Receptor Antagonists; Age Factors; Animals; Blood Pressure; Cardiomegaly; Famotidi | 2018 |
Nebivolol prevents desensitization of β-adrenoceptor signaling and induction of cardiac hypertrophy in response to isoprenaline beyond β1-adrenoceptor blockage.
Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-Agonists; Animals; Atrial Natriuretic Factor | 2013 |
Comparison of pharmacodynamics between carvedilol and metoprolol in rats with isoproterenol-induced cardiac hypertrophy: effects of carvedilol enantiomers.
Topics: Adenylyl Cyclases; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Pressur | 2008 |
Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach.
Topics: Adrenergic beta-Antagonists; Animals; Calcium Signaling; Cardiomegaly; Disease Models, Animal; Fibro | 2009 |
Cardiac magnetic resonance aids in the diagnosis of mitochondrial cardiomyopathy.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Cardiomegaly; Chest Pain; Female; Hearing Lo | 2011 |
Transforming growth factor β₁ oppositely regulates the hypertrophic and contractile response to β-adrenergic stimulation in the heart.
Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Angio | 2011 |
Hormonal regulation of β-myosin heavy chain expression in the mouse left ventricle.
Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Cardiomegaly; Female; Heart Ventricles; Hemodynamic | 2013 |
Cocaine produces cardiac hypertrophy by protein kinase C dependent mechanisms.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Cardiomegaly; Cells, Cultured; C | 2003 |
Enhanced isoproterenol-induced cardiac hypertrophy in transgenic rats with low brain angiotensinogen.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Angiotensinogen; Animals; Animals, Geneticall | 2006 |
Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction.
Topics: Adrenergic beta-Antagonists; Animals; beta-Adrenergic Receptor Kinases; Blood Pressure; Blood Vessel | 2006 |
Divergence of hypertrophic growth and fetal gene profile: the influence of beta-blockers.
Topics: Adrenergic beta-Antagonists; Animals; Cardiomegaly; Gene Expression Profiling; Gene Expression Regul | 2007 |
Comparative evaluation of atenolol and metoprolol on cardiovascular complications associated with streptozotocin-induced diabetic rats.
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Blood Glucose; Blood Pressure; Cardiomegaly; Cardiov | 2007 |
A study on the effects of some drugs on DOCA induced hypertension in the rat.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Cardiomegaly; Desoxycorticosterone; Diuretics; H | 1980 |
Adrenergic beta receptors mediating submandibular salivary gland hypertrophy in the rat.
Topics: Adrenergic beta-Agonists; Animals; Cardiomegaly; Dose-Response Relationship, Drug; Hypertrophy; Isop | 1981 |
Effect of beta-adrenergic receptor blockade on development of training-induced bradycardia in rats.
Topics: Adrenergic beta-Antagonists; Animals; Cardiomegaly; Female; Heart Rate; Metoprolol; Organ Size; Phys | 1981 |
Possible adrenergic effects on heart protein metabolism.
Topics: Adrenergic beta-Antagonists; Amino Acids; Animals; Biological Transport; Cardiomegaly; Cardiomyopath | 1983 |
[Regression of left ventricular hypertrophy by a prolonged anti-hypertensive treatment].
Topics: Aged; Antihypertensive Agents; Cardiomegaly; Chlorthalidone; Female; Humans; Male; Metoprolol; Middl | 1982 |
[Effects of long-term treatment with various antihypertensive drugs on the cardiac mass and on the hemodynamics of patients with essential arterial hypertension].
Topics: Adult; Cardiac Output; Cardiomegaly; Clonidine; Echocardiography; Heart; Humans; Hypertension; Methy | 1983 |
Left ventricular hypertrophy regression in hypertensive patients treated with metoprolol.
Topics: Adult; Blood Pressure; Cardiomegaly; Catecholamines; Echocardiography; Hemodynamics; Humans; Hyperte | 1984 |
Regression of structural cardiovascular changes by antihypertensive therapy in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Cardiovascular System; Circadian Rhy | 1984 |
Chronic propranolol treatment blunts right ventricular hypertrophy in rats at high altitude.
Topics: Adaptation, Physiological; Altitude; Animals; Cardiomegaly; Hypoxia; Male; Metoprolol; Polycythemia; | 1980 |
Combined treatment with ramipril and metoprolol prevents changes in the creatine kinase isoenzyme system and improves hemodynamic function in rat hearts after myocardial infarction.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Cardiomegaly; Creati | 2000 |
Possible mechanism of regression of myocardial hypertrophy.
Topics: Adrenergic beta-Antagonists; Animals; Apoptosis; Cardiomegaly; Hypertension, Renovascular; Male; Met | 2001 |
Hemodynamic and reflex sympathetic control of transmural activation and rate of ventricular tachycardia in ischemic and hypertrophic ventricular myocardium of the dog.
Topics: Adrenergic beta-Antagonists; Animals; Autonomic Nervous System; Cardiac Pacing, Artificial; Cardiome | 1992 |
Cardiac adaptation and its limitation in an experimental model of congestive heart failure.
Topics: Adaptation, Physiological; Animals; Cardiomegaly; Cricetinae; Heart; Heart Failure; In Vitro Techniq | 1992 |
Regression of left ventricular hypertrophy by felodipine or a combination of felodipine and metoprolol.
Topics: Cardiomegaly; Drug Therapy, Combination; Felodipine; Female; Humans; Male; Metoprolol; Middle Aged | 1990 |
The effect of metoprolol on left ventricular systolic and diastolic function in essential hypertension.
Topics: Adult; Aged; Cardiomegaly; Delayed-Action Preparations; Diastole; Echocardiography; Electrocardiogra | 1991 |
Incidence of sudden cardiac death associated with coronary artery occlusion in dogs with hypertension and left ventricular hypertrophy is reduced by chronic beta-adrenergic blockade.
Topics: Adrenergic beta-Antagonists; Animals; Cardiomegaly; Coronary Circulation; Coronary Disease; Death, S | 1990 |
Significance of coronary circulation in hypertensive heart disease for development and prevention of heart failure.
Topics: Adult; Animals; Cardiac Output, Low; Cardiomegaly; Coronary Circulation; Coronary Disease; Coronary | 1990 |
Metoprolol suppresses the development of ethanol-induced cardiac hypertrophy in the rat.
Topics: Adrenal Glands; Alcoholic Intoxication; Animals; Body Weight; Cardiomegaly; Catecholamines; Epinephr | 1990 |
Changes in ventricular fibrillation threshold during the development of perinephritic hypertension.
Topics: Animals; Atropine; Blood Pressure; Cardiac Pacing, Artificial; Cardiomegaly; Dogs; Electrophysiology | 1990 |
Regression of left ventricular mass is accompanied by improvement in rapid left ventricular filling following antihypertensive therapy with metoprolol.
Topics: Adult; Blood Pressure; Cardiomegaly; Echocardiography; Female; Heart; Heart Rate; Humans; Hypertensi | 1989 |
Antitrophic properties of antihypertensive drugs may depend solely on their blood pressure-lowering capability. A comparative study of isradipine, hydralazine, and metoprolol.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cardiomegaly; Coronary V | 1989 |
[Long-term treatment of hypertension with a selective beta-1-blockader without sympathomimetic activity. II. Changes in the structure and function of the left ventricle].
Topics: Cardiomegaly; Diastole; Drug Evaluation; Heart; Heart Ventricles; Humans; Hypertension; Metoprolol; | 1989 |
Sympathetic nerves modify mitochondrial and capillary growth in normotensive and hypertensive rats.
Topics: Animals; Blood Pressure; Capillaries; Cardiomegaly; Coronary Circulation; Heart Rate; Heart Ventricl | 1989 |
Impending myocardial infarction in a patient with marked left ventricular hypertrophy and normal coronary arteriogram--a case report.
Topics: Angiocardiography; Angiography; Cardiomegaly; Coronary Angiography; Echocardiography; Electrocardiog | 1989 |
[Regression of myocardial hypertrophy in hypertensives on chronic beta-receptor block].
Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Carbazoles; Cardiomegaly; Carvedilol; Chronic Di | 1986 |
Myocardial hypertrophy in rats with renal insufficiency.
Topics: Adenosine Triphosphatases; Animals; Blood Pressure; Blood Transfusion; Calcium; Cardiomegaly; Hydral | 1985 |
Long-term effect of antihypertensive therapy on left ventricular hypertrophy.
Topics: Adult; Antihypertensive Agents; Atenolol; Cardiomegaly; Drug Therapy, Combination; Echocardiography; | 1987 |