metoprolol has been researched along with Blood Pressure, High in 981 studies
Metoprolol: A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
metoprolol : A propanolamine that is 1-(propan-2-ylamino)propan-2-ol substituted by a 4-(2-methoxyethyl)phenoxy group at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of the study was to evaluate the efficacy and safety of fixed-dose combination (FDC) of metoprolol, telmisartan, and chlorthalidone in patients with essential hypertension and stable coronary artery disease (CAD) who showed inadequate response to dual therapy." | 9.51 | Fixed-dose Combination of Metoprolol, Telmisartan, and Chlorthalidone for Essential Hypertension in Adults with Stable Coronary Artery Disease: Phase III Study. ( Agrawal, S; Anand, J; Bachani, D; Doshi, M; Gaikwad, VB; Halder, SK; Kinholkar, B; Kumar, DA; Kumbhar, A; Mathur, R; Mehta, S; Sarkar, G; Sharma, A, 2022) |
| "There is little evidence guiding selection of nondiuretic, antihypertensive agents with a goal of lowering uric acid (SUA) and minimizing gout risk." | 9.24 | Metoprolol Increases Uric Acid and Risk of Gout in African Americans With Chronic Kidney Disease Attributed to Hypertension. ( Appel, LJ; Juraschek, SP; Miller, ER, 2017) |
| "The objective of this article is to compare blood pressure (BP)-lowing effects of nitrendipine and hydrochlorothiazide and nitrendipine and metoprolol, and estimate the economic effect of these therapies on hypertension." | 9.24 | Cost-effectiveness of nitrendipine and hydrochlorothiazide or metoprolol to treat hypertension in rural community health centers in China. ( Chen, Z; Hao, G; Li, Y; Ma, L; Wang, X; Wang, Z; Zhang, L; Zhao, X; Zhu, M, 2017) |
| "We planned to compare the impact of two beta blockers, metoprolol and nebivolol, on arterial blood pressure during exercise in patients with mild hypertension." | 9.17 | Effects of metoprolol and nebivolol on exercise blood pressure in patients with mild hypertension. ( Aydar, Y; Birdane, A; Ozduman, H; Yazici, HU, 2013) |
| "org: NCT01238705) in 160 women (18-60 years) with mild or moderate hypertension, randomized to a once-daily treatment with felodipine combined with irbesartan or metoprolol for 48 weeks." | 9.16 | Effect of felodipine with irbesartan or metoprolol on sexual function and oxidative stress in women with essential hypertension. ( Bai, F; Lin, X; Ma, R; Xu, D; Yang, L; Yu, J; Zhao, F, 2012) |
| "We aimed to compare the effects of two beta-blockers (metoprolol and carvedilol) on the lipid profiles of hyperthyroid patients with hypertension." | 9.16 | The impact of carvedilol and metoprolol on serum lipid concentrations and symptoms in patients with hyperthyroidism. ( Eren, MA; Ozbilen, S; Sabuncu, T; Turan, MN, 2012) |
| "To determine advantages of therapy of functional class (FC) I-II chronic heart failure (CHF) with preserved left ventricular (LV) ejection fraction in patients with hypertensive disease (HD) with metoprolol succinate or quinapril and to assess their effect on regulatory-adaptive status." | 9.16 | [Advantages of quinapril therapy in patients with arterial hypertension and functional class III chronic heart failure with preserved left ventricular ejection fraction]. ( Kanorskiĭ, SG; Pokrovskiĭ, VM; Tregubov, VG, 2012) |
| "We evaluated the effect of atenolol vs metoprolol succinate on vascular function in patients with essential hypertension." | 9.15 | Effect of atenolol vs metoprolol succinate on vascular function in patients with hypertension. ( Heffernan, KS; Karas, RH; Kuvin, JT; Mooney, P; Patvardhan, EA; Suryadevara, R, 2011) |
| "FDCs of metoprolol and amlodipine are effective and safe in mild to moderate hypertension." | 9.15 | Effect of fixed dose combinations of metoprolol and amlodipine in essential hypertension: MARS--a randomized controlled trial. ( Bosco, B; Devi, P; Ds, C; Gupta, R; Hiremath, J; Joshi, S; Mehta, K; Murthy, S; Nambiar, A; Pais, P; Pandey, S; Sharma, K; Sigamani, A; Singh, G; Thomas, T; Xavier, D, 2011) |
| " metoprolol (METO), induce erectile dysfunction (ED) in men." | 9.14 | Erectile dysfunction after therapy with metoprolol: the Hawthorne effect. ( Cocco, G, 2009) |
| " We compared the impact of two beta-blockers, metoprolol succinate (extended release) and nebivolol, on sleep quality in patients with stage 1 hypertension." | 9.13 | Impact of beta-blockers on sleep in patients with mild hypertension: a randomized trial between nebivolol and metoprolol. ( Erdem, A; Tandogan, I; Turgut, OO; Yalta, K; Yilmaz, A; Yilmaz, MB, 2008) |
| "The current study revealed that early pharmacological intervention had strong beneficial effects on aortic elasticity in patients with prehypertension despite the fact that neither metoprolol nor perindopril was superior to the other." | 9.13 | The comparative effects of metoprolol and perindopril on aortic elasticity in young patients with prehypertension. ( Acikel, C; Baysan, O; Celik, M; Celik, T; Isik, E; Iyisoy, A; Yaman, H; Yuksel, C, 2008) |
| "Nebivolol, in contrast to metoprolol, improved oxidative stress, insulin sensitivity, decreased plasma soluble P-selectin and increased adiponectin levels in hypertensive patients." | 9.12 | Comparative effects of nebivolol and metoprolol on oxidative stress, insulin resistance, plasma adiponectin and soluble P-selectin levels in hypertensive patients. ( Celik, T; Fici, F; Isik, E; Iyisoy, A; Kardesoglu, E; Kilic, S; Kursaklioglu, H; Ozcan, O; Turhan, H; Yaman, H; Yilmaz, MI, 2006) |
| " Our study aimed to confirm that beta(1)-adrenergic receptor polymorphisms affect the blood pressure response to metoprolol monotherapy in the Chinese population with hypertension." | 9.12 | beta1-Adrenergic receptor polymorphisms influence the response to metoprolol monotherapy in patients with essential hypertension. ( Li, Q; Liu, J; Liu, YZ; Liu, ZQ; Mo, W; Xu, FH; Yu, BN; Zhou, G; Zhou, HH, 2006) |
| "To evaluate the efficacy, safety and tolerance of Felodipine controlled release tablets and Felodipine controlled release tablets associated combination each with Metoprolol, Lisinopril or Hydrochlorothiazide in the 12 weeks treatment of mild to moderate essential hypertension in China." | 9.12 | [Efficacy, safety and tolerance of Felodipine controlled release tablets and Felodipine controlled release tablets associated combination therapy in the treatment of mild to moderate essential hypertension in China]. ( Chen, YY; Liu, HL; Shen, FR; Sun, NL; Tao, J; Wu, HY; Xiang, XP; Yu, ZQ; Zhang, FC; Zhang, L; Zhang, WZ; Zhao, JA, 2007) |
| "Both beta-blockers were well tolerated; use of carvedilol in the presence of RAS blockade did not affect glycemic control and improved some components of the metabolic syndrome relative to metoprolol in participants with DM and hypertension." | 9.11 | Metabolic effects of carvedilol vs metoprolol in patients with type 2 diabetes mellitus and hypertension: a randomized controlled trial. ( Anderson, KM; Bakris, GL; Bell, DS; Fonseca, V; Katholi, RE; Lukas, MA; McGill, JB; Messerli, FH; Oakes, R; Phillips, RA; Raskin, P; Wright, JT, 2004) |
| "To study effects of fosinopril on a 24-h profile of blood pressure (BP) in hypertensive patients with obesity and hypercholesterolemia." | 9.11 | [Effects of ACE inhibitor fosinopril on a 24-h profile of arterial pressure in hypertensive patients with obesity and hypercholesterolemia]. ( Gapon, LI; Pliusnin, AV; Popova, SN; Veber, EE; Vershinina, AM, 2005) |
| "Recent studies have shown that hyperhomocysteinemia might play a role in the pathogenesis of hypertension." | 9.11 | Beta blocker effects on plasma homocysteine levels in patients with hypertension. ( Atar, I; Atar, IA; Aydinalp, A; Bozbaş, H; Demircan, S; Korkmaz, ME; Müderrisoğlu, H; Ozin, B; Yildirir, A, 2005) |
| "We evaluated insulin sensitivity in two groups of essential hypertensive subjects before and after treatment with either long-acting nifedipine (nifedipine-CR, Adalat CR tablets; Bayer Yakuhin, Osaka, Japan) (n = 10) or metoprolol (n = 9)." | 9.10 | Improvement of insulin sensitivity by a long-acting nifedipine preparation (nifedipine-CR) in patients with essential hypertension. ( Harano, Y; Kodama, K; Koyama, Y; Suzuki, M, 2002) |
| "The Telmisartan Effectiveness on Left ventricular MAss Reduction (TELMAR) trial will assess the effect of the angiotensin II (Ang II) receptor blocker, telmisartan, on left ventricular hypertrophy (LVH) compared with the b-blocker, metoprolol, at similar antihypertensive doses." | 9.10 | Reduction (TELMAR) as assessed by magnetic resonance imaging in patients with mild-to-moderate hypertension--a prospective, randomised, double-blind comparison of telmisartan with metoprolol over a period of six months rationale and study design. ( Dahlöf, B; Dietz, R; Friedrich, MG; Knecht, M; Sechtem, U; Unger, T, 2003) |
| "To compare efficacy and safety of nifedipin-retard (cordaflex-retard, Egis, Hungary) used in monotherapy and in combination with metoprolol (egilok, Egis, Hungary) in patients with arterial hypertension (AH)." | 9.10 | [Assessment of the efficacy and tolerance of delayed-action nifedipine as the monotherapy or in combination with metoprolol in patients with arterial hypertension]. ( Andreeva, GF; Dmitrieva, NA; Gorbunov, VM; Isaĭkina, OIu; Martsevich, SIu, 2003) |
| "We describe the effect of controlled-release/extended-release (CR/XL) metoprolol succinate once daily on mortality and hospitalizations among patients with a history of hypertension complicated by chronic systolic heart failure." | 9.10 | Effects of metoprolol CR/XL on mortality and hospitalizations in patients with heart failure and history of hypertension. ( Denny, M; Fenster, P; Herlitz, J; Heywood, T; Masszi, G; Rasmussen, S; Thorgeirsson, G; Wachtell, K; Wikstrand, J, 2002) |
| "In this multicentre, double-blind, parallel-group study, 120 out-patients with mild to moderate primary hypertension were randomised, after a 4-week single-blind placebo run-in period, to a combination tablet of felodipine-metoprolol 5/50 mg (Logimax, Mobloc, Astra) once daily or enalapril 10 mg once daily." | 9.09 | Improved efficacy with maintained tolerability in the treatment of primary hypertension. Comparison between the felodipine-metoprolol combination tablet and monotherapy with enalapril. Swedish Multicentre Group. ( Andersson, OK, 1999) |
| "Out of 245 randomized outpatients (90 men, 155 women) with uncomplicated mild-to-moderate primary hypertension and mean sitting diastolic blood pressure (DBP) 95-115 mmHg inclusive, 212 (102 on felodipine-metoprolol, 110 on amlodipine) were eligible for analysis." | 9.09 | Ambulatory 24-h blood pressure assessment of the felodipine-metoprolol combination versus amlodipine in mild to moderate hypertension. Lorraine General Physician Investigators Group. ( Boivin, JM; Zannad, F, 1999) |
| "Ramipril, compared with amlodipine, retards renal disease progression in patients with hypertensive renal disease and proteinuria and may offer benefit to patients without proteinuria." | 9.09 | Effect of ramipril vs amlodipine on renal outcomes in hypertensive nephrosclerosis: a randomized controlled trial. ( Agodoa, LY; Appel, L; Bakris, GL; Beck, G; Bourgoignie, J; Briggs, JP; Charleston, J; Cheek, D; Cleveland, W; Douglas, JG; Douglas, M; Dowie, D; Faulkner, M; Gabriel, A; Gassman, J; Greene, T; Hall, Y; Hebert, L; Hiremath, L; Jamerson, K; Johnson, CJ; Kopple, J; Kusek, J; Lash, J; Lea, J; Lewis, JB; Lipkowitz, M; Massry, S; Middleton, J; Miller, ER; Norris, K; O'Connor, D; Ojo, A; Phillips, RA; Pogue, V; Rahman, M; Randall, OS; Rostand, S; Schulman, G; Smith, W; Thornley-Brown, D; Tisher, CC; Toto, RD; Wright, JT; Xu, S, 2001) |
| "The efficacy and tolerability of controlled-release metoprolol (metoprolol CR/ZOK), 100-200 mg, and atenolol, 50-100 mg, once daily was compared in Chinese patients with mild to moderate essential hypertension." | 9.08 | A double-blind comparison of once-daily metoprolol controlled-release and atenolol in the treatment of Chinese patients with mild to moderate hypertension. ( Chen, MF; Chen, WJ; Lee, CM; Lee, YT; Liau, CS; Wu, CC; Yang, CY, 1995) |
| "The effects of perindopril and metoprolol on left ventricular hypertrophy (LVH) and function were studied in 47 essential hypertensive patients with LVH." | 9.08 | Effect of perindopril and metoprolol on left ventricular hypertrophy and performance in essential hypertension. ( Chen, X; Dai, Z; Hui, Y; Wang, W, 1995) |
| "To study the relationship between insulin sensitivity and sodium-lithium countertransport (Na(+)-Li+ CT) in mild, essential hypertension, and to investigate the effect of metformin and metoprolol, respectively." | 9.08 | Relationship between sodium-lithium countertransport and insulin sensitivity in mild hypertension. ( Herlitz, H; Landin, K; Widgren, B, 1996) |
| " Therefore, we carried out a randomized, double-blind study to compare the effects of losartan (50 mg QD) and metoprolol (95 mg QD) on insulin sensitivity, insulin secretion, glucose tolerance, and lipids and lipoproteins in 20 hyperinsulinemic subjects with essential hypertension." | 9.08 | Effects of losartan on insulin sensitivity in hypertensive subjects. ( Karjalainen, L; Laakso, M; Lempiäinen-Kuosa, P, 1996) |
| "To evaluate the effect of metoprolol on insulin sensitivity and diurnal plasma hormone levels, seven mildly hypertensive subjects were investigated (four men and three women, age 52 +/- 8, body mass index 25." | 9.08 | The effect of metoprolol treatment on insulin sensitivity and diurnal plasma hormone levels in hypertensive subjects. ( Attvall, S; Bengtsson, BA; Elam, M; Fowelin, J; Gudbjörnsdóttir, S; Lönnroth, P; Mårin, P, 1997) |
| "To compare the long-term effects of the angiotensin-converting enzyme (ACE)-inhibitor quinapril and the cardioselective beta-adrenergic blocking agent metoprolol on glycaemic control, with glycosylated haemoglobin (HbA1c) as the principal variable, in non-insulin-dependent diabetes mellitus (NIDDM) patients with hypertension." | 9.08 | Comparison of effects of quinapril and metoprolol on glycaemic control, serum lipids, blood pressure, albuminuria and quality of life in non-insulin-dependent diabetes mellitus patients with hypertension. Swedish Quinapril Group. ( Asplund, K; Bystedt, T; Dahlöf, B; Jern, S; Kjellström, T; Lithell, H; Ostman, J, 1998) |
| "This study investigated the effects of an osmotic release oral drug delivery system of metoprolol on the changes induced by cumulative doses of inhaled salbutamol on bronchomotor tone, skeletal muscle, and the circulatory system after single (day 1) and multiple (day 7) dosing in 18 hypertensive asthmatic patients (forced expiratory volume in 1 second > 50% predicted; diastolic blood pressure > 90 mm Hg)." | 9.07 | Osmotic release oral drug delivery system of metoprolol in hypertensive asthmatic patients. Pharmacodynamic effects on beta 2-adrenergic receptors. ( Bauer, K; Kaik, B; Kaik, G, 1994) |
| "The authors assessed in 20 subjects with mild or medium severe arterial hypertension basal and stimulated values of plasma renin activity (PRA) and aldosterone before onset of treatment and after 6-week therapy with enalapril (ENAP KRKA) or metoprolol (Vasocardin Slovakofarma)." | 9.07 | [The importance of studying the renin-angiotensin-aldosterone system in essential arterial hypertension in clinical practice. Activity of the renin-angiotensin-aldosterone system during treatment of hypertension with ACE-inhibitors and beta blockers]. ( Chamulová, M; Hrnciar, J; Hrnciarová, M; Kreze, A; Lepej, J; Okálová, D, 1994) |
| "To compare the effects of treatment with nicardipine and metoprolol in patients with hypertension during pregnancy." | 9.07 | Nicardipine versus metoprolol in the treatment of hypertension during pregnancy: a randomized comparative trial. ( Carbonne, B; Jannet, D; Milliez, J; Sebban, E, 1994) |
| "This study compared with placebo the efficacy and tolerability of optimised doses of felodipine 5-20 mg daily, metoprolol 50-200 mg daily and their combination in subjects 60 years or over with isolated systolic hypertension." | 9.07 | Felodipine, metoprolol and their combination compared with placebo in isolated systolic hypertension in the elderly. ( Bune, AJ; Chalmers, JP; Russell, AE; Tonkin, AL; West, MJ; Wing, LM, 1994) |
| "The antianginal activities of nicorandil, 10 and 20 mg bid, and metoprolol, 100 mg bid, were compared in patients with stable effort angina pectoris in a randomized, double-blind parallel group study lasting 7 weeks." | 9.07 | A double-blind comparison of nicorandil and metoprolol in stable effort angina pectoris. ( Bokor, D; Carotenuto, A; de Divitiis, M; de Divitiis, O; Di Somma, S; Liguori, V; Petitto, M, 1993) |
| "The plasma drug concentration-effect relationship after an oral dose of 100 mg metoprolol has been studied in 8 women in the third trimester of a pregnancy complicated by hypertension." | 9.07 | Plasma concentration-effect relationship of metoprolol during and after pregnancy. ( Högstedt, S; Rane, A, 1993) |
| "To assess the short-term efficacy and safety of metoprolol in the treatment of hypertension in a large population of older patients." | 9.07 | Safety and efficacy of metoprolol in the treatment of hypertension in the elderly. ( Glasser, S; LaPalio, L; Schork, A; Tifft, C, 1992) |
| "The antihypertensive effect of captopril, metoprolol, and hydrochlorothiazide was compared in 23 non-insulin-dependent (NIDDM) diabetic patients less than or equal to 75 years of age, with borderline to moderate primary hypertension." | 9.07 | Placebo-controlled comparison of captopril, metoprolol, and hydrochlorothiazide therapy in non-insulin-dependent diabetic patients with primary hypertension. ( Beck-Nielsen, H; Faergeman, O; Gall, MA; Gerdes, LU; Hommel, E; Lauritzen, M; Mathiesen, ER; Rossing, P; Skøtt, P; Vølund, A, 1992) |
| "In a randomized, double-blind, parallel group study, diltiazem was compared with metoprolol as add-on therapy to diuretic treatment in 115 patients with hypertension." | 9.07 | Diltiazem compared with metoprolol as add-on-therapies to diuretics in hypertension. Swedish Diltiazem-Metoprolol Multicentre Study Group. ( Gustafsson, S; Hedner, T; Olsson, SO; Thulin, T, 1991) |
| "In two separate but similarly designed placebo-controlled studies, the efficacy of metoprolol CR/ZOK 50 mg once daily was evaluated in 64 patients (mean age 53 years) with mild hypertension (Study I) and in 34 elderly patients (mean age 68 years) with mild to moderate hypertension (Study II)." | 9.06 | The efficacy of low dose metoprolol CR/ZOK in mild hypertension and in elderly patients with mild to moderate hypertension. ( Baandrup, S; Houtzagers, J; Jäättelä, A; Westergren, G, 1990) |
| "In a double-blind study with parallel groups, the clinical bioequivalence of the antihypertensive effect of metoprolol CR/ZOK (controlled release formulation) 50 mg and atenolol 50 mg in ordinary tablets given once daily for uncomplicated hypertension was investigated." | 9.06 | A double-blind comparison of metoprolol CR/ZOK 50 mg and atenolol 50 mg once daily for uncomplicated hypertension. ( Berger, J; Klein, G; Menzel, T; Olsson, G, 1990) |
| "We studied the effect of phenylpropanolamine on blood pressures in seven patients whose hypertension was controlled with beta blockers." | 9.06 | The effect of single-dose phenylpropanolamine on blood pressure in patients with hypertension controlled by beta blockers. ( Gross, CR; O'Connell, MB, 1990) |
| "We assessed the efficacy of long-acting nifedipine as monotherapy in 52 patients with mild to moderate essential hypertension in a randomized, controlled crossover study." | 9.06 | Long-acting nifedipine versus metoprolol as monotherapy for essential hypertension. A randomized, controlled crossover study. ( Pun, CO; Woo, KS, 1990) |
| "A double-blind controlled, randomized, parallel, multicenter 12-week study was conducted to compare the antihypertensive efficacy of lisinopril with that of metoprolol in treatment of moderate to severe hypertension." | 9.06 | Evaluation of antihypertensive efficacy of lisinopril compared to metoprolol in moderate to severe hypertension. ( Bonnet, G; Chrysant, SG; DeBacker, G; Goldstein, R; Herrera, J; Lindner, A; Materson, BJ; Maxwell, MH; McMahon, FG; Zachariah, PK, 1987) |
| "The article presents the experience gained with a new betablocker- bopindolol-in the treatment of hypertension." | 9.06 | Bopindolol in the treatment of hypertension: a double blind study comparing bopindolol and metoprolol. ( Lefflerová, K; Lupínek, Z; Lupínková, Z; Miklis, P; Uhlír, O; Widimský, J; Zeman, K; Zicha, J, 1989) |
| "A material of 76 patients from general practice treated with diuretics for mild to moderate hypertension were randomized to supplementary treatment with captopril (39 patients) and metoprolol (37 patients), respectively, on account of diastolic blood pressure greater than or equal to 95 mmHg." | 9.06 | [The effects of captopril and metoprolol on blood pressure and side effects in patients with mild to moderate hypertension]. ( Kornerup, HJ; Korsager, S, 1989) |
| "The safety and efficacy of step-one therapy with enalapril, a new angiotensin-converting enzyme inhibitor, and metoprolol were compared in a double-blind, multicenter study involving 150 patients who had mild to moderate essential hypertension." | 9.06 | A comparison of enalapril and metoprolol as initial therapy for mild to moderate hypertension. ( Miola, SR; Nugent, LW; Walker, JF, 1987) |
| "The blood pressure of patients with hypertension who were aged between 60 and 75 years responded equally well to treatment with metoprolol (100 mg a day) or hydrochlorothiazide (25 mg a day) in a double-blind study which employed random allocation to two parallel groups." | 9.06 | Metoprolol or hydrochlorothiazide in patients with hypertension aged 60-75 years. With special reference to assessment of compliance. Hunter Hypertension Research Group. ( , 1986) |
| "The long-term safety and efficacy of ketanserin in the treatment of essential hypertension was assessed in monotherapy or in combination with the beta-blocker, metoprolol." | 9.06 | Long-term safety and efficacy of ketanserin in essential hypertension: ketanserin versus or in combination with metoprolol. ( Mauersberger, H, 1986) |
| "Ketanserin (K), a selective and specific S2-receptor antagonist, has been compared with metoprolol (M), a cardioselective beta-blocker, in a double-blind study in order to assess its efficacy and safety in the treatment of essential hypertension." | 9.06 | Clinical experience with ketanserin in the treatment of hypertension. ( Assogna, G; Costantini, C; del Rosso, G; Libretti, A; Mara, G; Palermo, A; Pizza, N, 1986) |
| "To compare responses of blood pressure to the calcium antagonist verapamil and the beta blocker metoprolol in black compared with white diabetics with hypertension and to monitor urinary albumin excretion in relation to fall in blood pressure." | 9.06 | Treating hypertension in black compared with white non-insulin dependent diabetics: a double blind trial of verapamil and metoprolol. ( Anderson, NM; Cruickshank, JK; Jepson, E; Wadsworth, J; Young, SM, 1988) |
| "Single and combined therapy with terbutaline (10 mg/day) and metoprolol (200 mg/day) was assessed over 8 weeks in a double-blind parallel study in a total of 36 patients with essential hypertension grade I-II according to WHO criteria at rest and during exercise." | 9.06 | Beta-adrenoceptor stimulating and blocking agents in essential hypertension: single and combined therapy with terbutaline and metoprolol. ( Gotzen, R; Meyer-Sabellek, W; Röcker, L; Schulte, KL; Thiede, HM, 1987) |
| "In a double-blind study with parallel groups a new controlled-release (CR) formulation of metoprolol, 100 mg once daily, was compared with conventional metoprolol tablets, 100 mg once daily, in 27 patients with primary hypertension." | 9.06 | Effect of controlled-release metoprolol on blood pressure and exercise heart rate in hypertension: a comparison with conventional tablets. ( Kristensson, BE; Rydén, L; Westergren, G, 1988) |
| "The effects of acebutolol (with intrinsic sympathomimetic activity (ISA] and metoprolol (without ISA) on arm blood pressure, ankle systolic blood pressure, claudication distances (CD) and maximal walking distances (MWD) were compared in patients with essential hypertension and intermittent claudication." | 9.06 | The effects of acebutolol and metoprolol on walking distances and distal blood pressure in hypertensive patients with intermittent claudication. ( Jelnes, R; Svendsen, TL; Tønnesen, KH, 1986) |
| "The Stockholm Metoprolol Trial is a prospective double-blind placebo-controlled postmyocardial infarction study of 301 patients treated with metoprolol, 100 mg b." | 9.06 | Reduction of nonfatal reinfarctions in patients with a history of hypertension by chronic postinfarction treatment with metoprolol. ( Olsson, G; Rehnqvist, N, 1986) |
| "The hypertensive effect of urapidil, a new antihypertensive agent that acts via central and peripheral alpha-adrenoceptors, has been compared with that of metoprolol in 40 patients with mild essential hypertension." | 9.06 | Comparison of the antihypertensive effect of urapidil and metoprolol in hypertension. ( Boni, S; Guffanti, E; Leonetti, G; Mazzola, C; Meani, A; Zanchetti, A, 1986) |
| "Monotherapy with Ketanserin, a serotonin receptor antagonist, reduces blood pressure in a sizeable number of patients with essential hypertension." | 9.06 | Ketanserin in the treatment of essential hypertension. A double-blind study against metoprolol and a further long-term open treatment. ( Bernardiner, E; Lemus, J; Milei, J, 1986) |
| "Ketanserin, a serotonin receptor antagonist (S2), lowered blood pressure in patients with essential hypertension; at three months 72% (13/18) had a successful reduction in pressure." | 9.06 | Comparison of ketanserin and metoprolol in the treatment of essential hypertension. ( Agerter, DC; Araas, FJ; Collins, JB; Fisher, LD; Schirger, A; Sheps, SG; Spiekerman, RE; Zachariah, PK, 1987) |
| "Thirty-two patients with mild to moderate essential hypertension completed this double-blind cross-over clinical trial of propranolol and metoprolol." | 9.06 | Double-blind, randomized, cross-over clinical trial of metoprolol and propranolol in mild to moderate essential hypertension. ( Pandhi, P; Sahai, J; Sharma, BK; Sharma, PL; Wahi, PL, 1987) |
| "In a double-blind, comparative study metoprolol (100 to 300 mg/day) or pindolol (5 to 15 mg/day) was given in randomized order to 39 patients with uncomplicated essential hypertension." | 9.06 | Hemodynamics of metoprolol and pindolol in systemic hypertension with particular reference to reversal of structural vascular changes. ( Hansson, L, 1986) |
| "Women with previously untreated arterial hypertension have been followed up during ten years of beta-blocker treatment, first for three years with alprenolol and then for seven years with the selective beta1-blocker metoprolol." | 9.05 | Seven years on a selective beta-blocker - metoprolol. A long-term study of women with arterial hypertension. ( Bengtsson, C, 1981) |
| "Twenty-five patients with moderate essential hypertension (standing diastolic blood pressure 100-125 mmHg, phase 5) completed a single-blind placebo-controlled cross-over study comparing four week periods of treatment with atenolol 100 mg, metoprolol 100 mg, metoprolol durules 200 mg, slow-release oxprenolol 160 mg, and slow-release oxprenolol 320 mg respectively." | 9.05 | Comparative study of atenolol, metoprolol, metoprolol durules, and slow-release oxprenolol in essential hypertension. ( Hampton, JR; Wilcox, RG, 1981) |
| "9 years) with mild to moderate essential hypertension a comparison between equipotent beta-blocking doses of propranolol, metoprolol and labetalol was carried out." | 9.05 | Propranolol vs metoprolol vs labetalol: a comparative study in essential hypertension. ( Coote, JH; Kubik, MM, 1984) |
| "Atenolol 100 mg once daily and metoprolol SA 200 mg once daily were compared in 20 patients with mild to moderate hypertension, in a randomised, double-blind cross-over trial." | 9.05 | A comparison of once daily atenolol and metoprolol SA in mild to moderate hypertension. ( Cavalcanti, C; Morley, CA; Perrins, EJ; Sutton, R, 1983) |
| "The antihypertensive effects of oral labetalol, a new alpha- and beta-adrenergic blocking agent, and metoprolol, a relatively beta1 selective adrenergic blocker, were evaluated in 91 patients with mild to moderate hypertension (standing diastolic blood pressure of 90 to 115 mm Hg) in a double-blind parallel group multicenter clinical trial." | 9.05 | Multiclinic comparison of labetalol to metoprolol in treatment of mild to moderate systemic hypertension. ( Frishman, WH; Johnson, BF; Michelson, EL; Poland, MP, 1983) |
| "In a placebo-controlled double-blind study 14 hypertensive patients with intermittent claudication were treated with metoprolol (100-200 mg daily) and methyldopa (500-1000 mg daily) for 3 weeks and their effects on heart rate, blood pressure as well as on resting and hyperaemic calf blood flow and vascular resistance were compared." | 9.05 | Chronic effects of metoprolol and methyldopa on calf blood flow in intermittent claudication. ( Lepäntalo, M, 1984) |
| "In a placebo-controlled double-blind crossover trial, the effect of a 3-week course of treatment with metoprolol (100-200 mg daily) and methyldopa (500-1000 mg daily) on walking capacity on a treadmill with increasing work load was studied in 14 hypertensive patients with intermittent claudication." | 9.05 | Walking capacity of patients with intermittent claudication during chronic antihypertensive treatment with metoprolol and methyldopa. ( Lepäntalo, M; von Knorring, J, 1984) |
| "The biochemical disturbance produced by thiazide diuretics and by amiloride during treatment of moderate hypertension were compared." | 9.05 | Comparison of thiazides and amiloride in treatment of moderate hypertension. ( Thomas, JP; Thomson, WH, 1983) |
| "The results of an uncontrolled and open study of a once-a-day dosage of metoprolol (Betaloc) in the management of mild to moderate hypertension are described." | 9.05 | Metoprolol for hypertension. Open trial in general practice. ( Fredman, RM, 1982) |
| "A double-blind crossover trial was undertaken to compare the efficacy of sustained-release clonidine and long-acting propranolol in the treatment of 20 patients (8 males and 12 females) with sustained hypertension." | 9.05 | Comparison of sustained-release clonidine and long-acting propranolol in the treatment of hypertension. ( Lawson, AA; Rodrigues, E, 1982) |
| "The clinical efficacy of propranolol and metoprolol slow-release tablets (Durules) was compared in 20 patients with typical angina pectoris and concomitant hypertension." | 9.05 | Metoprolol in angina pectoris complicated by essential hypertension. A clinical comparison of the antianginal efficacy of metoprolol slow-release tablets (Durules) given once daily and propranolol tablets given twice daily. ( BLoem, TJ; Lindner, PC, 1981) |
| "The effect of once-daily dosage of the two most widely prescribed cardioselective beta-adrenoceptor antagonists used to treat hypertension--namely, atenolol and metoprolol--was studied in nine carefully selected hypertensive outpatients." | 9.05 | Atenolol and metoprolol once daily in hypertension. ( Hawksworth, GM; Lovell, HG; Petrie, JC; Rigby, JW; Scott, AK; Webster, J, 1982) |
| "Thirty patients with essential hypertension (WHO Stage I or II) completed a double blind crossover trial in which they received metoprolol as monotherapy as either a slow release formulation of 200 mg once daily or a conventional formulation of 100 mg bd." | 9.05 | Sustained release metoprolol: a comparison with conventional formulation in the treatment of hypertension. ( Flacks, LM; Goldstraw, PW; Kiddle, GB; Logan, RL; Watt, M, 1981) |
| "After a two-week run-in period on placebo, fifty-two patients with benign essential hypertension (WHO classes I or II) were treated with individually titrated doses of metoprolol or propranolol for 36 weeks." | 9.05 | Metoprolol and propranolol in the treatment of essential hypertension - a long-term comparative study. ( Sjöberg, KH, 1981) |
| "The effect of metoprolol, a beta1-selective receptor blocking agent without intrinsic stimulating activity, on blood pressure, pulse and plasma concentration 2 and 24 h after dose intake and on working capacity and perceived exertion 2 h after dose intake was investigated when given as 100 mg and 200 mg conventional tablets or 200 mg slow-release tablets (Durules) once daily, long-term, to 20 patients with primary (essential) hypertension." | 9.05 | Metoprolol administered once daily in the treatment of hypertension. A double-blind crossover comparison between conventional tablets and metoprolol Durules. ( Asplund, J; Ohman, P, 1981) |
| "In a double-blind study comprising 31 patients with essential hypertension not satisfactorily controlled on hydrochlorothiazide 25 mg o." | 9.05 | Comparative study of hydrochlorothiazide and a fixed combination of metoprolol and hydrochlorothiazide essential hypertension. ( Dafgärd, T; Forsén, B; Lindahl, T, 1981) |
| "Seventy-one patients with mild-to-moderate essential hypertension completed 14 weeks' treatment with a single daily dose of fixed combination of metoprolol tartrate 100 mg and chlorthalidone 25 mg (Logroton; Geigy)." | 9.05 | A fixed combination of metoprolol and chlorthalidone in hypertension. A clinical trial in general practice. ( Govind, U; Munro, BF; Robertson, LI, 1981) |
| "The clinical effects, the exercise test answer, the left ventricular function by polygraphyc test after administration at middle term of Metoprolol and Labetalol have been evaluated in 20 patients with moderate and non complicated essential hypertension." | 9.05 | [Clinical, ergometric and polygraphic evaluation of the effects of metoprolol and labetalol administration in essential arterial hypertension. Comparative study]. ( Attisano, N; Grenci, G; Martelli, G; Sarica, G; Schirripa, V, 1982) |
| "In a double-blind trial 26 patients with essential hypertension were treated with nifedipine or placebo for 8 weeks, following a 4-week run-in-placebo period in all patients." | 9.05 | Effects of treatment with nifedipine and metoprolol in essential hypertension. ( Eggertsen, R; Hansson, L, 1982) |
| " Thirty-six patients with essential hypertension, were randomly allocated to double-blind treatment with either metoprolol (100--200 mg/day) or pindolol (5--10 mg/day)." | 9.05 | Metoprolol and pindolol in hypertension: different effects on peripheral haemodynamics. ( Gudbrandsson, T; Hansson, L; Sivertsson, R; Svensson, A, 1981) |
| "1 In an open, randomized cross-over investigation of thirteen patients (nine and four women, aged 37-67 years) with mild or moderate essential hypertension a comparison between atenolol and metoprolol was carried out in order to study the effects of 50, 100 and 200 mg given once daily on blood pressure and heart rate at rest and during exercise." | 9.05 | A comparative study of atenolol and metoprolol in the treatment of hypertension. ( Arnung, K; Eskildsen, PC; Nielsen, PE; Rasmussen, S, 1981) |
| "The efficacy of metoprolol as an antihypertensive agent was assessed in 20 previously untreated Asian patients with mild to moderate hypertension." | 9.05 | A comparison between once-daily and twice-daily administration of metoprolol in the management of hypertension. ( Chia, BL, 1980) |
| "Weight reduction was compared with metoprolol (200 mg daily) in a randomised placebo-controlled trial of first-line treatment of mild hypertension (diastolic blood pressure 90-109 mm Hg) in 56 overweight patients aged under 55 years." | 9.05 | Comparison of weight reduction with metoprolol in treatment of hypertension in young overweight patients. ( Andrews, G; Bernstein, L; Blacket, RB; Macdonald, GJ; MacMahon, SW, 1985) |
| "Ketanserin, an investigational, antiserotonergic agent, at a dose of 40 mg bid was given to 18 patients with mild to moderate primary hypertension in a randomized, double-blind, crossover study, with 100-mg metoprolol bid for four weeks each." | 9.05 | Cardiovascular effects of ketanserin, a new antiserotonergic agent in the treatment of arterial hypertension. ( Fasano, ML; Ferrara, LA; Iannuzzi, A; Rubba, P; Soro, S, 1985) |
| "In an open, controlled trial, treatment with a combination of metoprolol and hydralazine was compared with non-pharmacological management of mild and moderate hypertension in pregnancy." | 9.05 | A prospective controlled trial of metoprolol-hydralazine treatment in hypertension during pregnancy. ( Axelsson, O; Högstedt, S; Lindberg, BS; Lindeberg, S; Lindmark, G; Rane, A; Sandström, B, 1985) |
| "The antihypertensive effects on metoprolol and pindolol were compared in 50 patients with essential hypertension belonging to WHO stage 1 or 2." | 9.04 | A comparison between metoprolol and pindolol in the treatment of essential hypertension. ( Pohjola, M; Tuomilehto, J, 1978) |
| "After a control period on a placebo, 45 patients with mild to moderate hypertension were treated with metoprolol, 100 mg twice daily alone and in free combination with chlorthalidone 50 mg daily using a double-blind crossover technique." | 9.04 | Metoprolol with and without chlorthalidone in hypertension. ( Ebbutt, A; John, V; Kendall, M; Kubik, M, 1979) |
| "The antihypertensive effect of the selective beta-1-adrenoceptor blocker, metoprolol, administered once daily was evaluated in 32 patients with primary hypertension." | 9.04 | Once-daily metoprolol in primary hypertension. ( Karlberg, BE; Nilsson, O; Nitelius, E; Tolagen, K; Waern, U, 1979) |
| " The adequacy of the control of essential hypertension during exercise was studied in patients whose resting blood pressure had been controlled for 1 year with either metoprolol or methyldopa." | 9.04 | Effect of exercise in hypertension controlled with metoprolol or methyldopa. ( Barbour, MP; Hillis, WS; Lawrie, TD; Linden, RJ; Lorimer, AR; Sreeharan, N; Stoker, JB, 1979) |
| " The effect of a single dose of propranolol and metoprolol were compared with placebo in two groups of patients with untreated essential hypertension." | 9.04 | Objective measurement of performance during acute stress in patients with essential hypertension: assessment of the effects of propranolol and metoprolol. ( Dunn, FG; Lawrie, TD; Lorimer, AR, 1979) |
| "In 19 patients with arterial hypertension the hemodynamics were determined with a Swan-Ganz-thermodilution catheter at rest and during supine ergometer exercise before and after 5 mg intravenous Propranolol (P) (10 pats." | 9.04 | [Hemodynamic changes in patients with arterial hypertension after beta-receptor blockade with propranolol and metoprolol (author's transl)]. ( Greding, H; Isbary, J; König, E; Nechwatal, W, 1978) |
| "The hypotensive actions of metoprolol and alpha-methyldopa have been compared in 37 men with previously untreated essential hypertension; 36 belonged to stage 1 and 1 to stage 2 of the WHO classification." | 9.04 | Comparative study of metoprolol and alpha-methyldopa in untreated essential hypertension. ( Berglund, G; Bergstrand, RH; Vedin, JA; Wilhelmsson, CE, 1976) |
| "In the review the basic studies devoted to researching of effectiveness of metoprolol in treatment of essential hypertension and also influence of this drug in the prognosis in this group of patients, are summarized." | 8.82 | [Metoprolol in the treatment of essential hypertension]. ( Minushkina, LO; Sidorenko, BA, 2003) |
| "Conventional formulations of metoprolol have become well established in cardiovascular medicine and are particularly useful in the management of hypertension and ischaemic heart disease." | 8.78 | Controlled release metoprolol formulations. A review of their pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension and ischaemic heart disease. ( Clissold, SP; Plosker, GL, 1992) |
| "Multiclinic controlled studies have shown that enalapril alone 10 to 40 mg/day orally is effective in lowering blood pressure in patients with essential hypertension." | 8.77 | Enalapril in hypertension and congestive heart failure. Overall review of efficacy and safety. ( Davies, RO; Moncloa, F; Sromovsky, JA; Walker, JF, 1985) |
| "During the intervening years since metoprolol was first reviewed in the Journal (1977), it has become widely used in the treatment of mild to moderate hypertension and angina pectoris." | 8.77 | Metoprolol. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in hypertension, ischaemic heart disease and related cardiovascular disorders. ( Benfield, P; Brogden, RN; Clissold, SP, 1986) |
| "To observe the effect of amlodipine besylate combined with metoprolol in treating hypertension and heart failure." | 8.31 | Improvement in hemodynamics of amlodipine besylate combined with metoprolol in patients with hypertension complicated by heart failure. ( Chen, C; Jiao, D; Shen, J; Zhang, W; Zhang, X; Zhu, G, 2023) |
| "Metoprolol succinate is a long-acting beta-blocker prescribed for the management of hypertension (HTN) and other cardiovascular diseases." | 7.96 | Metabolomic profiling of metoprolol hypertension treatment reveals altered gut microbiota-derived urinary metabolites. ( Brocker, CN; Flaten, HK; Gonzalez, FJ; Krausz, KW; McDaniel, K; McWilliams, G; Monte, AA; Saben, J; Shelton, SK; Velenosi, T, 2020) |
| "Methyldopa and amlodipine are associated with the least side effects in pregnant women treated for chronic hypertension." | 7.96 | The comparison of side effects of methyldopa, amlodipine, and metoprolol in pregnant women with chronic hypertension. ( Ghafarzadeh, M; Namdari, P; Shakarami, A; Yari, F, 2020) |
| " In this study, we characterised left ventricular thrombospondin-1 and -4 expression in rats treated with a beta-blocker metoprolol during the remodelling process in response to pressure overload and acute myocardial infarction." | 7.76 | Metoprolol treatment lowers thrombospondin-4 expression in rats with myocardial infarction and left ventricular hypertrophy. ( Aro, J; Leskinen, H; Luodonpää, M; Mustonen, E; Ruskoaho, H; Rysä, J; Vuolteenaho, O, 2010) |
| "Obvious elevation of PP is associated with a better response to metoprolol succinate sustained-release tablets in elderly hypertensive patients with chronic heart failure, and 3 months of treatment with the tablets can significantly improve the cardiac function and lower the levels of VEGF, hs-CRP and BNP in these patients." | 7.76 | [Response to metoprolol succinate sustained-release tablets in correlation to pulse pressure, serum vascular endothelial growth factor and C-reactive protein in elderly hypertensive patients with chronic heart failure]. ( Lin, ZP; Zhang, ZW, 2010) |
| "The aim of this work was to study effects of metoprolol on structural and functional characteristics of left ventricle (LV), cerebral circulation (CC), microcirculation (MC), lipid spectrum, rheologic and viscous properties of blood in patients with grade II-III hypertensive disease (HD) and metabolic syndrome." | 7.76 | [Hypertensive disease and metabolic syndrome: application of metoprolol]. ( Koren'kov, VV; Markova, EV; Markova, LI; Radzevich, AE; Samoĭlenko, TN; Sokolova, NV, 2010) |
| "The objective of this study was to compare cardiovascular and renal events in patients with hypertension receiving the angiotensin II-receptor blocker valsartan versus those receiving the angiotensin-converting-enzyme lisinopril or the beta-blocker metoprolol succinate in an extended-release formulation." | 7.74 | Valsartan versus lisinopril or extended-release metoprolol in preventing cardiovascular and renal events in patients with hypertension. ( Delea, TE; Frech-Tamas, F; Moynahan, A; Oster, G; Taneja, C; Thomas, SK, 2007) |
| " Nondiabetics with hypertension (N=30) were started on (or changed to) hydrochlorothiazide (HCTZ) 12." | 7.73 | Metoprolol succinate, a selective beta-adrenergic blocker, has no effect on insulin sensitivity. ( Falkner, B; Francos, G; Kushner, H, 2006) |
| "Chronic treatment with cyclosporine A (CsA), a potent immunosuppressive agent, is associated with the development of arterial hypertension." | 7.72 | Role of metoprolol, B1-adrenoceptor antagonist, thromboxane A2 and nitric oxide in CsA-induced hypertension. ( Oriji, GK, 2003) |
| "To compare efficacy and safety of cardioselective beta-adrenoblockers nebivolol and metoprolol in patients with hypertension and ischemic heart disease (IHD) combined with type 2 diabetes." | 7.72 | [Clinical and metabolic effects of cardioselective beta-adrenoblockers nebivolol and metoprolol in patients with hypertension and ischemic heart disease associated with type 2 diabetes]. ( Akhmedova, OO; Buval'tsev, VI; Gavrilov, IuV; Makolkin, VI; Petriĭ, VV, 2003) |
| "Centrally acting (moxonidine) and peripherally acting (metoprolol) sympatholytic agents might have different actions upon penile circulation in hypertensive men with erectile dysfunction." | 7.72 | Effects of moxonidine and metoprolol in penile circulation in hypertensive men with erectile dysfunction: results of a pilot study. ( Kaaja, R; Piha, J, 2003) |
| "The Metoprolol CR/XL Randomized Intervention Trial in Chronic Heart Failure (MERIT-HF), the Cardiac Insufficiency Bisoprolol Study II (CIBIS-II), and the Carvedilol Prospective Randomized Cumulative Survival Study (COPERNICUS) have all demonstrated highly significant positive effects on total mortality as well as total mortality plus all-cause hospitalization in patients with heart failure." | 7.72 | How should subgroup analyses affect clinical practice? Insights from the Metoprolol Succinate Controlled-Release/Extended-Release Randomized Intervention Trial in Heart Failure (MERIT-HF). ( Deedwania, P; Fagerberg, B; Ghali, J; Goldstein, S; Gottlieb, S; Hjalmarson, A; Kjekshus, J; Waagstein, F; Wedel, H; Wikstrand, J, 2003) |
| "Bupropion is an increasingly prescribed agent to aid in smoking cessation." | 7.72 | Severe sinus bradycardia after initiation of bupropion therapy: a probable drug-drug interaction with metoprolol. ( Greene, JL; McCollum, DL; McGuire, DK, 2004) |
| " Postoperatively, the patient had persistent sinus tachycardia that was initially unsuccessfully treated with metoprolol." | 7.70 | Treatment of milrinone-associated tachycardia with beta-blockers. ( Alhashemi, JA; Hooper, J, 1998) |
| "We present results from a Swedish retrospective cost-effectiveness analysis of felodipine-metoprolol (Logimax) and enalapril in hypertension." | 7.70 | Cost-effectiveness of felodipine-metoprolol (Logimax) and enalapril in the treatment of hypertension. ( Andersson, F; Andersson, OK; Kartman, B, 1998) |
| " The patient was treated with the cardioselective beta-blocking agent, metoprolol, initially for elevated blood pressure and tachycardia at 25 mg twice daily for approximately 2 months." | 7.69 | Metoprolol for action tremor following intracerebral hemorrhage. ( Dove, CA; Escobar, N; Vezzetti, D, 1994) |
| "Eighteen previously untreated primary hypertension patients were selected for therapy either with 50-250 mg/day metoprolol (n = 11) or with 3-20 mg/day prazosin (n = 8)." | 7.69 | Differences between the effects of metoprolol and prazosin on the forearm vasculature in primary hypertension. ( Gretzer, I; Hjemdahl, P, 1997) |
| " This article describes the case of a patient affected by pheochromocytoma in whom multiple organ failure developed after contemporary administration of ergotamine, caffeine, and nimesulide." | 7.69 | Pheochromocytoma crisis caused by contemporary ergotamine, caffeine, and nimesulide administration. ( Bartoli, P; Bonechi, F; Brandinelli, A; Del Rosso, A; Fradella, G; Ieri, A; Maioli, M; Mannelli, M; Mazza, F; Russo, L; Sansoni, M; Zipoli, A, 1997) |
| "We compared the antihypertensive effects of acebutolol and metoprolol during 2-4 weeks of treatment in patients with mild to moderate essential hypertension." | 7.68 | [The effect of acebutolol and metoprolol on noninvasive ambulatory blood pressure monitoring system in essential hypertension]. ( Hayashi, T; Ichinohe, T; Ikeda, S; Ikeda, Y; Kawaguchi, K; Kotake, C; Koya, Y; Onaka, H; Seo, T; Suyama, K, 1992) |
| "Using ultrasound techniques, parameters of left ventricular systolic and diastolic function were assessed in 23 patients with degree I-II essential hypertension treated with metoprolol." | 7.68 | The effect of metoprolol on left ventricular systolic and diastolic function in essential hypertension. ( Hradec, J; Král, J; Petrásek, J, 1991) |
| "In 30 hypertensives with angina pectoris the acute action of beta-blockers Celiprolol and Metoprolol on the global and coronary haemodynamics was tested within cardiac catheter diagnostics." | 7.68 | [Acute changes of coronary and global hemodynamics in patients with angina pectoris and arterial hypertension caused by celiprolol and metoprolol]. ( Bruch, L; Franz, N; Gola, G; Heublein, B; Linss, G; Modersohn, D; Walde, T, 1990) |
| "We compared the effects of the angiotensin-converting enzyme inhibitor enalapril and a conventional antihypertensive regimen (hydralazine and metoprolol) on kidney function, albuminuria, and glomerular ultrastructure in hypertensive diabetic and nondiabetic rats." | 7.68 | Nephropathy in model combining genetic hypertension with experimental diabetes. Enalapril versus hydralazine and metoprolol therapy. ( Allen, TJ; Clarke, BE; Cooper, ME; Doyle, AE; Jerums, G; O'Brien, RC; Papazoglou, D, 1990) |
| "One hundred twenty-six patients with mild to moderate hypertension responsive to beta-adrenergic blocking agents--alone or in combination with other antihypertensive drugs--entered this open-label, multicenter study designed to evaluate the safety and tolerability of metoprolol OROS (metoprolol fumarate)." | 7.68 | Safety and tolerability of metoprolol OROS in hypertension treatment. ( Feliciano, N; Goldstein, RJ; Grau, KE; Hogan, LB; Kasarjian, PH; Kessler, C; McMillen, JI; Montoro, R; Mroczek, WJ; Stevelman, HB, 1990) |
| "The authors tested in an open, uncontrolled trial in a group of 23 patients with essential hypertension grade I-II (WHO classification) the effect of Metoprolol OROS." | 7.68 | [The effect of OROS metoprolol in mild and moderately severe essential hypertension]. ( Hradec, J; Král, J; Petrásek, J, 1990) |
| " We assessed both the renal and the systemic haemodynamic responses to antihypertensive monotherapy (five to seven weeks) with the angiotensin converting enzyme (ACE) inhibitor enalapril (n = 12), in contrast to the cardioselective beta-adrenergic blocker metoprolol (n = 11) in subjects with essential hypertension." | 7.67 | Contrasting renal haemodynamic responses to the angiotensin converting enzyme inhibitor enalapril and the beta-adrenergic antagonist metoprolol in essential hypertension. ( Bernstein, KN; Cervenka, J; Mosley, CA; O'Connor, DT, 1984) |
| "Treatment of fifteen patients with essential hypertension over four weeks using the beta 1-adrenoceptor blocking agent, metoprolol, resulted in a decrease in 24 h urinary excretion of kallikrein and aldosterone along with a decrease in plasma renin activity." | 7.67 | Effect of metoprolol on 24-hour urinary excretion of adrenal steroids and kallikrein in patients with essential hypertension. ( Fritschka, E; Gotzen, R; Kittler, R; Schöneshöfer, M, 1984) |
| "The effects of chlorthalidone and metoprolol on fasting plasma lipids and lipoprotein levels were compared in two similar nonrandomized groups of patients with mild hypertension." | 7.67 | Different effects of metoprolol and chlorthalidone on serum lipoprotein levels in mild hypertension. Possible implications for coronary heart disease risk status. ( Goldbourt, U; Holtzman, E; Rosenthal, T; Segal, P, 1984) |
| "The acute haemodynamic effect of metoprolol was investigated in 14 patients with essential hypertension (7 of the WHO stage I, 7 of stage II)." | 7.67 | Acute haemodynamic effect of metoprolol in essential hypertension. ( Mikulecký, M; Pechán, J; Srbecký, M, 1988) |
| "A dose titration study was performed using felodipine, a new calcium antagonist, in Chinese patients with essential hypertension inadequately controlled by metoprolol alone (DBP greater than 95 mmHg)." | 7.67 | The effects of combining felodipine and metoprolol in moderate to severe hypertension--a one year study. ( Chow, J, 1988) |
| "Oral administration of felodipine to 10 patients with mild essential hypertension acutely reduced systemic vascular resistance (SVR) by 40% after 30 min." | 7.67 | Acute haemodynamic and humoral responses to felodipine and metoprolol in mild hypertension. ( Amery, A; Fagard, R; Lijnen, P; Moerman, E; Staessen, J, 1987) |
| "Five women who developed hypertension during pregnancy received metoprolol, 10 mg iv; 3 days later they received metoprolol, 100 mg by mouth." | 7.67 | Pregnancy-induced increase in metoprolol metabolism. ( Högstedt, S; Lindberg, B; Peng, DR; Rane, A; Regårdh, CG, 1985) |
| "Twenty-nine patients with severe hypertension (n = 14) or hypertensive crisis (n = 15) were treated with diazoxide infusion and intravenous injection of a beta blocker." | 7.66 | Combined intravenous administration of diazoxide and beta-blocking agent in acute treatment of severe hypertension or hypertensive crisis. ( Huysmans, FT; Koene, RA; Thien, TA, 1982) |
| "The efficacy of metoprolol, a new cardioselective beta-blocking drug, was compared with that of methyldopa in patients with mild to moderate essential hypertension in a long-term study." | 7.66 | A comparative study of metoprolol and methyldopa in the treatment of hypertension. ( Karachalios, GN, 1983) |
| "A fixed combination of metoprolol slow-release 200 mg and chlorthalidone 25 mg was given once daily over a 3 months period in forty out-patients with mild-to-moderate arterial hypertension stage I or II WHO." | 7.66 | A fixed combination of metoprolol slow-release and chlorthalidone, given once daily, in the long-term treatment of arterial hypertension. ( Bichisao, E; Floris, B; Franchetta, G; Palestini, N; Sonaglioni, G; Verdecchia, P, 1982) |
| "10 patients with systemic essential arterial hypertension have been treated with 200 mg/die of Metoprolol." | 7.66 | [The effects of metoprolol on systolic times in patients with systemic arterial hypertension. Polygraphic study]. ( Attisano, N; Grenci, G; Martelli, G; Sarica, G; Schirripa, V, 1982) |
| "The cardioselective betablocking agent metoprolol was used to treat 21 outpatients with essential arterial hypertension graded 1 and 2 of the OMS scale." | 7.66 | [Metoprolol in the treatment of essential hypertension (author's transl)]. ( Beiras García, E; Pérez Pombo, S; Salgueiro Rodríguez, M, 1981) |
| "The antihypertensive effect and the tolerability of metoprolol Durules have been studied in fifty-five patients with mild to moderate hypertension." | 7.66 | Experiences with metoprolol Durules, a slow-release formulation in hypertension. ( Nissinen, A; Tuomilehto, J, 1980) |
| "The effect of the cardioselective beta-adrenoreceptor blocking compound, metoprolol, was compared with methyldopa in the long-term management of hypertension." | 7.66 | Long-term comparison of metoprolol and methyldopa in the treatment of hypertension. ( Barbour, M; Hillis, WS; Lawrie, TD; Leanage, RU; Linden, RJ; Lorimer, AR; Sreeharan, N; Stoker, JB, 1980) |
| "1 Twelve men with untreated essential hypertension in WHO stage I were studied on an outpatient basis to evaluate the haemodynamic long-term effect of a new beta-adrenoceptor blocker, metoprolol." | 7.65 | Haemodynamic long-term effects of metoprolol at rest and during exercise in essential hypertension. ( Lund-Johansen, P; Ohm, OJ, 1977) |
| "To investigate the effects of ivabradine in combination with perindopril on cerebral blood flow and endothelial functional activity." | 6.77 | [Cerebral blood flow and endothelial functional activity in patients with coronary heart disease and arterial hypertension during therapy with ivabradine in combination with perindopril]. ( Gapon, LI; Kolesnikova, SN; Musikhina, NA; Petelina, TI; Utesheva, AB, 2012) |
| "Arterial hypertension is characterised by increased oxidative stress and inflammation, which are associated with further cardiovascular risk." | 6.77 | Nebivolol and metoprolol: long-term effects on inflammation and oxidative stress in essential hypertension. ( Eha, J; Kals, J; Kampus, P; Kullisaar, T; Serg, M; Zagura, M; Zilmer, K; Zilmer, M, 2012) |
| "High blood pressure is one of the most important risk factors, directly responsible for increasing the cardiovascular morbidity and mortality." | 6.74 | Antihypertensive efficacy of metoprolol XL/low dose chlorthalidone (6.25 mg) combination: a randomized, comparative study in indian patients with mild-to-moderate essential hypertension. ( Chandurkar, NB; Karnik, ND; Pareek, A; Salagre, SB; Zawar, SD, 2009) |
| "Carvedilol effects were favorable to adjustment of age as a covariate." | 6.73 | Demographic analyses of the effects of carvedilol vs metoprolol on glycemic control and insulin sensitivity in patients with type 2 diabetes and hypertension in the Glycemic Effects in Diabetes Mellitus: Carvedilol-Metoprolol Comparison in Hypertensives ( ( Anderson, KM; Bakris, GL; Bell, DS; Fonseca, V; Iyengar, M; Katholi, RE; Lukas, MA; McGill, JB; Messerli, FH; Phillips, RA; Raskin, P; Wright, JT, 2008) |
| "Sibutramine treatment resulted in a significantly greater decrease in body weight, body mass index, and waist circumference and a significant increase in diastolic blood pressure during 24-hour blood pressure monitoring compared with placebo treatment." | 6.73 | Optimal treatment of obesity-related hypertension: the Hypertension-Obesity-Sibutramine (HOS) study. ( Grimm, E; Herrmann, D; Kintscher, U; Scholze, J; Unger, T, 2007) |
| "Hypertension is a significant cause of end-stage renal failure and effective treatment of hypertensive will reduce the progression rate of chronic renal failure in various kidney disorders." | 6.68 | Enalapril versus metoprolol in primary hypertension--effects on the glomerular filtration rate. ( Aurell, M; Bengtsson, C; Björck, S, 1997) |
| " Significantly fewer adverse events were experienced on lisinopril and metoprolol than on diuretic treatment." | 6.67 | Quality of life, side effects and efficacy of lisinopril compared with metoprolol in patients with mild to moderate essential hypertension. ( Bech, P; Frimodt-Moeller, J; Kornerup, HJ; Poulsen, DL, 1991) |
| "Bopindolol is a nonselective beta blocker with mild intrinsic sympathomimetic activity." | 6.67 | Bopindolol: Czechoslovak experience with a new beta blocker in the treatment of hypertension. ( Dvorák, I; Fedelesová, V; Lefflerová, K; Lupínek, Z; Mayer, O; Pinterová, E; Widimský, J, 1991) |
| "Celiprolol is a 'third generation' beta-blocking agent which is claimed to avoid problems associated with simpler beta-blockers, such as vasoconstriction, bronchoconstriction and myocardial depression." | 6.67 | Acute haemodynamic profile of celiprolol in patients with coronary heart disease and hypertension: a double-blind comparison with metoprolol. ( Franz, N; Heublein, B; Modersohn, D; Panzner, B, 1991) |
| " Altogether, 251 hypertensive patients with a diastolic blood pressure greater than 95 mm Hg after 4 weeks of treatment with placebo in combination with metoprolol CR 100 mg were randomized to four parallel groups." | 6.67 | Optimal felodipine dose when combined with metoprolol in arterial hypertension: a Swedish multicenter study within primary health care. Swedish General Practitioner Felodipine Study Group. ( Bengtsson, C; Brun, J; Fröberg, L; Kronmann, P; Olsson, LB; Scherstén, B; Skoog, P; Tibblin, G; Tygesen, G, 1990) |
| "In a randomized double-blind multicenter study in 100 hypertensive patients, the effect of once daily (od) dosing with a new controlled release (CR/ZOK) formulation of metoprolol was compared with that of twice daily (bid) dosing with metoprolol conventional tablets." | 6.67 | A comparison of a controlled release (CR/ZOK) formulation of metoprolol, once daily, with conventional metoprolol tablets, twice daily, in mild to moderate hypertension. ( Carruthers, G; Moore, M; Shearer, R; Taylor, W, 1990) |
| "Ketanserin appears to be a new alternative approach in the treatment of mild and moderate essential hypertension." | 6.66 | Ketanserin versus metoprolol in the treatment of essential hypertension. ( Bernardiner, E; Lemus, J; Milei, J, 1986) |
| " Simplification of the dosage regimen to once-daily therapy appears to improve the patient's willingness to comply with the physician's instructions." | 6.65 | A study of efficacy, tolerance and compliance of once-daily versus twice-daily metoprolol (Betaloc) in hypertension. Betaloc Compliance Canadian Cooperative Study Group. ( Baird, MG; Bentley-Taylor, MM; Carruthers, SG; Dawson, KG; Laplante, LE; Larochelle, P; MacCannell, KL; Marquez-Julio, A; Silverberg, LR; Talbot, P, 1984) |
| " Patients who responded (diastolic BP less than 95 mmHg) continued on the initial dosage regimen." | 6.65 | Metoprolol and atenolol administered once daily in primary hypertension. A clinical comparison of the efficacy of two selective beta-adrenoceptor blocking agents. ( Lyngstam, O; Rydén, L, 1981) |
| "105 patients with previously untreated hypertension entered the trial and 72 completed it." | 6.65 | Double-blind comparison of metoprolol, alprenolol, and oxprenolol in hypertension. ( Nissinen, A; Tuomilehto, J, 1979) |
| "Metoprolol 120 mg/d was significantly superior to propranolol 240 mg/d in holding the diastolic supine blood pressure at less than or equal to 90 mmHg." | 6.64 | South African multicentre study of metoprolol and propranolol in essential hypertension. ( Bosman, AR; Goldberg, B; McKechnie, JK; Offermeier, J; Oosthuizen, OJ, 1977) |
| " In one study that titrated dosages to effect, fewer felodipine/metoprolol than felodipine or metoprolol monotherapy recipients required dosage increases to achieve BP control (45 vs 60 and 67%, respectively)." | 6.41 | Felodipine/metoprolol: a review of the fixed dose controlled release formulation in the management of essential hypertension. ( Haria, M; Markham, A; Plosker, GL, 2000) |
| "Metoprolol is a beta 1-selective adrenoceptor antagonist that is widely used in several indications." | 6.39 | Metoprolol: a pharmacoeconomic and quality-of-life evaluation of its use in hypertension, post-myocardial infarction and dilated cardiomyopathy. ( Benfield, P; Peters, DH, 1994) |
| "Metoprolol is a beta1-selective adrenoceptor blocking drug." | 6.36 | Metoprolol: a review of its pharmacological properties and therapeutic efficacy in hypertension and angina pectoris. ( Avery, GS; Brogden, RN; Heel, RC; Speight, TM, 1977) |
| "The aim of the study was to evaluate the efficacy and safety of fixed-dose combination (FDC) of metoprolol, telmisartan, and chlorthalidone in patients with essential hypertension and stable coronary artery disease (CAD) who showed inadequate response to dual therapy." | 5.51 | Fixed-dose Combination of Metoprolol, Telmisartan, and Chlorthalidone for Essential Hypertension in Adults with Stable Coronary Artery Disease: Phase III Study. ( Agrawal, S; Anand, J; Bachani, D; Doshi, M; Gaikwad, VB; Halder, SK; Kinholkar, B; Kumar, DA; Kumbhar, A; Mathur, R; Mehta, S; Sarkar, G; Sharma, A, 2022) |
| "Our data show a potential pharmacokinetic interaction, most likely via CYP3A4 between amlodipine and RIS, reflected in significantly different C/Ds for RIS, 9-OH-RIS and AM." | 5.43 | Pharmacokinetic considerations in the treatment of hypertension in risperidone-medicated patients - thinking of clinically relevant CYP2D6 interactions. ( Gründer, G; Haen, E; Lammertz, SE; Paulzen, M; Schoretsanitis, G; Schruers, KR; Stegmann, B; Walther, S, 2016) |
| "ER metoprolol was then added to their ongoing therapy." | 5.35 | Treatment with metoprolol succinate, a selective beta adrenergic blocker, lowers blood pressure without altering insulin sensitivity in diabetic patients. ( Falkner, B; Kushner, H, 2008) |
| " As comparisons to metoprolol succinate as well as to optimally dosed metoprolol tartrate are missing, a definite superiority of carvedilol cannot be assumed." | 5.34 | [Beta-adrenoceptor antagonists and ACE-inhibitors. Carvedilol compared with metoprolol as combination partner in cases of diabetes and hypertension]. ( Frese, T; Sandholzer, H, 2007) |
| "Beta-Blocker use can be associated with adverse effects that may have an impact on adherence or harm patients." | 5.32 | Pharmacokinetics and CYP2D6 genotypes do not predict metoprolol adverse events or efficacy in hypertension. ( Beitelshees, AL; Eberst, K; Gaedigk, A; Gelfand, CA; Johnson, JA; Leeder, JS; Pauly, DF; Phillips, MS; Walker, JR; Zineh, I, 2004) |
| "Metoprolol was without significant effect on any of these variables following chronic administration." | 5.30 | The beta2-adrenergic modulator celiprolol reduces insulin resistance in obese Zucker rats. ( Dietze, GJ; Fogt, DL; Henriksen, EJ; Jacob, S, 1999) |
| " During long-term use alpha-methyldopa frequently reduces the total peripheral resistance and the reduction in cardiac output is usually modest, at rest as well as during exercise." | 5.26 | alpha-Methyldopa and beta-blockers in hypertension--a comparison of their haemodynamic effects. ( Lund-Johansen, P, 1978) |
| "Minoxidil seems to be a safe and potent antihypertensive drug for long-term use in severe arterial hypertension, but it cannot be recommended for routine treatment." | 5.26 | Long-term experiences with minoxidil in combination treatment of severe arterial hypertension. ( Lederballe Pedersen, O, 1977) |
| " The mean resting blood pressures were 168/108 mmHg, 151/98 mmHg and 150/96 mmHg at pre-trial, after the twice-daily dosage period and after the once-daily dosage period, respectively." | 5.26 | A fixed combination of metoprolol and hydrochlorothiazide for hypertension: a multi-centre study. ( Goodfellow, RM, 1979) |
| "There is little evidence guiding selection of nondiuretic, antihypertensive agents with a goal of lowering uric acid (SUA) and minimizing gout risk." | 5.24 | Metoprolol Increases Uric Acid and Risk of Gout in African Americans With Chronic Kidney Disease Attributed to Hypertension. ( Appel, LJ; Juraschek, SP; Miller, ER, 2017) |
| "This open-label study investigated the long action of bisoprolol compared with metoprolol CR/ZOK for controlling the mean dynamic heart rate (HR) and blood pressure (BP) in patients with mild-to-moderate primary hypertension." | 5.24 | Comparison of bisoprolol to a metoprolol CR/ZOK tablet for control of heart rate and blood pressure in mild-to-moderate hypertensive patients: the CREATIVE study. ( Hao, Y; Jiang, Y; Lin, X; Ma, T; Qu, B; Xu, X; Yang, T; Zhou, S, 2017) |
| "The objective of this article is to compare blood pressure (BP)-lowing effects of nitrendipine and hydrochlorothiazide and nitrendipine and metoprolol, and estimate the economic effect of these therapies on hypertension." | 5.24 | Cost-effectiveness of nitrendipine and hydrochlorothiazide or metoprolol to treat hypertension in rural community health centers in China. ( Chen, Z; Hao, G; Li, Y; Ma, L; Wang, X; Wang, Z; Zhang, L; Zhao, X; Zhu, M, 2017) |
| "Beta-blockers have solid documentation in preventing cardiovascular complications in the treatment of hypertension; atenolol, metoprolol, oxprenolol and propranolol demonstrate proven cardiovascular prevention in hypertension mega-trials." | 5.22 | Diverse pharmacological properties, trial results, comorbidity prescribing and neural pathophysiology suggest European hypertension guideline downgrading of beta-blockers is not justified. ( Esler, M; Grassi, G; Kjeldsen, SE; Kreutz, R; Mancia, G; Pathak, A, 2022) |
| " The authors hypothesized that nebivolol, a selective β1 -antagonist that stimulates nitric oxide (NO), will improve endothelial function in AAs with hypertension when compared with metoprolol." | 5.22 | Nitric Oxide Contributes to Vasomotor Tone in Hypertensive African Americans Treated With Nebivolol and Metoprolol. ( Hayek, SS; Kavtaradze, N; Lefer, DJ; Menon, V; Neuman, RB; Polhemus, D; Poole, JC; Quyyumi, AA; Rahman, A; Veledar, E, 2016) |
| "Associations between ADRB polymorphisms and blood pressure response to ramipril were analyzed in the African American Study of Kidney Disease and Hypertension, a randomized clinical trial." | 5.20 | Association of the ADRB2 (rs2053044) polymorphism and angiotensin-converting enzyme-inhibitor blood pressure response in the African American Study of Kidney Disease and Hypertension. ( Anthony, EG; Bhatnagar, V; Lipkowitz, MS; Richard, E, 2015) |
| " A comparative study on the efficacy and safety of bisoprolol and sustained release metoprolol succinate in patients with arterial hypertension (AH), cardiovascular disease (CVD) and chronic obstructive pulmonary disease (COPD) was conducted." | 5.19 | [Efficacy and safety of bisoprololal in hypertensive patients with cardiovascular disease and chronic obstructive pulmonary disease]. ( Chernikov, MV; Derevianchenko, MV; Lopushkova, IuE; Statsenko, ME, 2014) |
| "The clinical data of 24 patients with ischemic stroke in our intensive care unit were analyzed, and received amlodipine or metoprolol for more than 14 days with 24-hour ambulatory blood pressure monitoring." | 5.19 | Effects of different antihypertensive drugs on blood pressure variability in patients with ischemic stroke. ( Hu, WL; Ji, M; Li, SJ, 2014) |
| " In 21 subjects with stage 1 hypertension, we measured muscle oxygenation and forearm blood flow responses to reflex increases in sympathetic nerve activity evoked by lower body negative pressure at rest, and during rhythmic handgrip exercise at baseline, after 12 weeks of nebivolol (5-20 mg/d) or metoprolol (100-300 mg/d), using a double-blind crossover design." | 5.17 | Differential effects of nebivolol versus metoprolol on functional sympatholysis in hypertensive humans. ( Adams-Huet, B; Arbique, D; Mitchell, JH; Price, A; Raheja, P; Thomas, GD; Victor, RG; Vongpatanasin, W; Wang, Z, 2013) |
| " Patients with type 2 diabetes and hypertension on maximal RAS blockade (n=70) were randomized to nebivolol or metoprolol succinate daily." | 5.17 | Effects of nebivolol on aortic compliance in patients with diabetes and maximal renin angiotensin system blockade: the EFFORT study. ( Bakris, G; Briasoulis, A; Flynn, C; Kalaitzidis, R; Lazich, I; Oliva, R; Schlaffer, C, 2013) |
| "We planned to compare the impact of two beta blockers, metoprolol and nebivolol, on arterial blood pressure during exercise in patients with mild hypertension." | 5.17 | Effects of metoprolol and nebivolol on exercise blood pressure in patients with mild hypertension. ( Aydar, Y; Birdane, A; Ozduman, H; Yazici, HU, 2013) |
| "org: NCT01238705) in 160 women (18-60 years) with mild or moderate hypertension, randomized to a once-daily treatment with felodipine combined with irbesartan or metoprolol for 48 weeks." | 5.16 | Effect of felodipine with irbesartan or metoprolol on sexual function and oxidative stress in women with essential hypertension. ( Bai, F; Lin, X; Ma, R; Xu, D; Yang, L; Yu, J; Zhao, F, 2012) |
| "We aimed to compare the effects of two beta-blockers (metoprolol and carvedilol) on the lipid profiles of hyperthyroid patients with hypertension." | 5.16 | The impact of carvedilol and metoprolol on serum lipid concentrations and symptoms in patients with hyperthyroidism. ( Eren, MA; Ozbilen, S; Sabuncu, T; Turan, MN, 2012) |
| "To determine advantages of therapy of functional class (FC) I-II chronic heart failure (CHF) with preserved left ventricular (LV) ejection fraction in patients with hypertensive disease (HD) with metoprolol succinate or quinapril and to assess their effect on regulatory-adaptive status." | 5.16 | [Advantages of quinapril therapy in patients with arterial hypertension and functional class III chronic heart failure with preserved left ventricular ejection fraction]. ( Kanorskiĭ, SG; Pokrovskiĭ, VM; Tregubov, VG, 2012) |
| "We evaluated the effect of atenolol vs metoprolol succinate on vascular function in patients with essential hypertension." | 5.15 | Effect of atenolol vs metoprolol succinate on vascular function in patients with hypertension. ( Heffernan, KS; Karas, RH; Kuvin, JT; Mooney, P; Patvardhan, EA; Suryadevara, R, 2011) |
| "This study focuses on the relationship between β(1)-adrenergic receptor (ADRB1) polymorphisms and blood pressure response to the β-blocker metoprolol among African Americans with early hypertensive nephrosclerosis." | 5.15 | β(1)-adrenergic receptor polymorphisms and response to β-blockade in the African-American study of kidney disease and hypertension (AASK). ( Aziz, H; Bhatnagar, V; Blantz, R; Brophy, V; Lee, J; Lipkowitz, M; Liu, L; O'Connor, DT; Richard, E; Wassel, CL, 2011) |
| "FDCs of metoprolol and amlodipine are effective and safe in mild to moderate hypertension." | 5.15 | Effect of fixed dose combinations of metoprolol and amlodipine in essential hypertension: MARS--a randomized controlled trial. ( Bosco, B; Devi, P; Ds, C; Gupta, R; Hiremath, J; Joshi, S; Mehta, K; Murthy, S; Nambiar, A; Pais, P; Pandey, S; Sharma, K; Sigamani, A; Singh, G; Thomas, T; Xavier, D, 2011) |
| " metoprolol (METO), induce erectile dysfunction (ED) in men." | 5.14 | Erectile dysfunction after therapy with metoprolol: the Hawthorne effect. ( Cocco, G, 2009) |
| "Ninety-six patients with essential hypertension received metoprolol (100 mg once daily) as monotherapy for 8 weeks." | 5.14 | Angiotensin-converting enzyme gene I/D genotype affected metoprolol-induced reduction in 24-hour average heart rate. ( Chen, GL; Han, LL; Huang, YL; Jiang, XJ; Li, YS; Liu, H; Liu, LW; Xu, ZM, 2010) |
| " We compared the impact of two beta-blockers, metoprolol succinate (extended release) and nebivolol, on sleep quality in patients with stage 1 hypertension." | 5.13 | Impact of beta-blockers on sleep in patients with mild hypertension: a randomized trial between nebivolol and metoprolol. ( Erdem, A; Tandogan, I; Turgut, OO; Yalta, K; Yilmaz, A; Yilmaz, MB, 2008) |
| "Forty-six hypertensive ADPKD patients were randomized to either ramipril (n = 23) or metoprolol (n = 23)." | 5.13 | Renal and cardiac effects of antihypertensive treatment with ramipril vs metoprolol in autosomal dominant polycystic kidney disease. ( Poliak, R; Schmieder, RE; Schulze, BD; Stiasny, B; Zeltner, R, 2008) |
| "The current study revealed that early pharmacological intervention had strong beneficial effects on aortic elasticity in patients with prehypertension despite the fact that neither metoprolol nor perindopril was superior to the other." | 5.13 | The comparative effects of metoprolol and perindopril on aortic elasticity in young patients with prehypertension. ( Acikel, C; Baysan, O; Celik, M; Celik, T; Isik, E; Iyisoy, A; Yaman, H; Yuksel, C, 2008) |
| "Nebivolol, in contrast to metoprolol, improved oxidative stress, insulin sensitivity, decreased plasma soluble P-selectin and increased adiponectin levels in hypertensive patients." | 5.12 | Comparative effects of nebivolol and metoprolol on oxidative stress, insulin resistance, plasma adiponectin and soluble P-selectin levels in hypertensive patients. ( Celik, T; Fici, F; Isik, E; Iyisoy, A; Kardesoglu, E; Kilic, S; Kursaklioglu, H; Ozcan, O; Turhan, H; Yaman, H; Yilmaz, MI, 2006) |
| "The African American Study of Kidney Disease and Hypertension was a multicenter trial comparing the effects of 2 levels of blood pressure control (usual or low goal) and initial therapy with metoprolol, ramipril, or amlodipine." | 5.12 | Quality of life in the African American Study of Kidney Disease and Hypertension: effects of blood pressure management. ( Gadegbeku, CA; Greene, T; Hall, Y; Jones, K; Kusek, JW; Lash, JP; Sika, M; Unruh, M; Wang, X, 2006) |
| " Our study aimed to confirm that beta(1)-adrenergic receptor polymorphisms affect the blood pressure response to metoprolol monotherapy in the Chinese population with hypertension." | 5.12 | beta1-Adrenergic receptor polymorphisms influence the response to metoprolol monotherapy in patients with essential hypertension. ( Li, Q; Liu, J; Liu, YZ; Liu, ZQ; Mo, W; Xu, FH; Yu, BN; Zhou, G; Zhou, HH, 2006) |
| "To evaluate the efficacy, tolerability, and blood pressure (BP) lowering effect of extended release metoprolol succinate (ER metoprolol) in children 6 to 16 years of age with established hypertension." | 5.12 | Efficacy and safety of extended release metoprolol succinate in hypertensive children 6 to 16 years of age: a clinical trial experience. ( Batisky, DL; Falkner, B; Hainer, JW; Klibaner, M; Llewellyn, M; Portman, RJ; Sorof, JM; Sugg, J, 2007) |
| "The Glycemic Effect in Diabetes Mellitus: Carvedilol-Metoprolol Comparison in Hypertensives (GEMINI) trial compared the metabolic effects of two beta-blockers in people with type 2 diabetes and hypertension treated with renin-angiotensin system (RAS) blockade and found differences in metabolic outcomes." | 5.12 | beta-blocker use and diabetes symptom score: results from the GEMINI study. ( Anderson, KM; Bakris, GL; Bell, DS; Dalal, MR; Fonseca, V; Iyengar, M; Katholi, RE; Lukas, MA; McGill, JB; Messerli, FH; Phillips, RA; Raskin, P; Wright, JT, 2007) |
| "In patients with diabetes and hypertension not taking insulin sensitizers, the use of metoprolol tartrate resulted in a worsening of insulin resistance, an effect not seen with carvedilol." | 5.12 | Differential effect of beta-blocker therapy on insulin resistance as a function of insulin sensitizer use: results from GEMINI. ( Anderson, KM; Bakris, GL; Bell, DS; Fonseca, V; Katholi, RE; Lukas, MA; McGill, JB; Messerli, FH; Phillips, RA; Raskin, P; Waterhouse, B; Wright, JT, 2007) |
| "In routine clinical practice in the management of angina (with or without coexisting hypertension), S-metoprolol administered at half the dose of the racemate, shows similar efficacy, safety and a trend towards a higher response rate." | 5.12 | Comparative clinical study of the efficacy and safety of a S-metoprolol ER tablet versus a racemate metoprolol ER tablet in patients with chronic stable angina. ( Aneja, P; Biswas, AD; Srinivas, A, 2007) |
| "Thirty-four patients with type 2 diabetes mellitus (T2DM) and hypertension were randomized to receive either carvedilol (n = 16) or metoprolol (n = 18) in addition to their current antihypertensive medications for 5 months." | 5.12 | Effects of carvedilol versus metoprolol on endothelial function and oxidative stress in patients with type 2 diabetes mellitus. ( Bank, AJ; Gonzalez-Campoy, JM; Kaiser, DR; Kelly, AS; Thelen, AM, 2007) |
| " The current analysis of the Glycemic Effect in Diabetes Mellitus: Carvedilol-Metoprolol Comparison in Hypertensives (GEMINI) trial evaluates the effects of carvedilol and metoprolol tartrate on weight gain in patients with type 2 diabetes and hypertension." | 5.12 | Body weight changes with beta-blocker use: results from GEMINI. ( Anderson, KM; Bakris, GL; Bangalore, S; Bell, DS; Fonseca, V; Holdbrook, FK; Katholi, RE; Lukas, MA; McGill, JB; Messerli, FH; Phillips, RA; Raskin, P; Wright, JT, 2007) |
| "We observed a significant increase in ADMA levels, a marker of endothelial dysfunction, during metoprolol treatment, whereas nebivolol had neutral effects on ADMA levels in patients with type 2 diabetes mellitus and hypertension." | 5.12 | Effect of nebivolol and metoprolol treatments on serum asymmetric dimethylarginine levels in hypertensive patients with type 2 diabetes mellitus. ( Fici, F; Hekim, N; Oğuz, A; Uzunlulu, M; Yalçin, Y; Yorulmaz, E, 2007) |
| "To evaluate the efficacy, safety and tolerance of Felodipine controlled release tablets and Felodipine controlled release tablets associated combination each with Metoprolol, Lisinopril or Hydrochlorothiazide in the 12 weeks treatment of mild to moderate essential hypertension in China." | 5.12 | [Efficacy, safety and tolerance of Felodipine controlled release tablets and Felodipine controlled release tablets associated combination therapy in the treatment of mild to moderate essential hypertension in China]. ( Chen, YY; Liu, HL; Shen, FR; Sun, NL; Tao, J; Wu, HY; Xiang, XP; Yu, ZQ; Zhang, FC; Zhang, L; Zhang, WZ; Zhao, JA, 2007) |
| "Addition of low-dose metoprolol to sibutramine therapy increased patient compliance to the treatment, and decreased the frequency and severity of side effects including hypertension and palpitations, without decreasing the drug efficacy or causing significant deleterious changes in metabolic parameters." | 5.11 | Effect of low-dose metoprolol in combination with sibutramine therapy in normotensive obese patients: a randomized controlled study. ( Baykan, M; Durmus, I; Erem, C; Ersoz, HO; Hacihasanoglu, A; Telatar, M; Ukinc, K, 2004) |
| "Both beta-blockers were well tolerated; use of carvedilol in the presence of RAS blockade did not affect glycemic control and improved some components of the metabolic syndrome relative to metoprolol in participants with DM and hypertension." | 5.11 | Metabolic effects of carvedilol vs metoprolol in patients with type 2 diabetes mellitus and hypertension: a randomized controlled trial. ( Anderson, KM; Bakris, GL; Bell, DS; Fonseca, V; Katholi, RE; Lukas, MA; McGill, JB; Messerli, FH; Oakes, R; Phillips, RA; Raskin, P; Wright, JT, 2004) |
| "The African American Study of Kidney Disease and Hypertension examined the effect on renal function decline of 2 blood pressure (BP) goals (low mean arterial pressure [MAP] < or =92 versus usual MAP 102 to 107 mm Hg) and 3 antihypertensives (ramipril versus amlodipine versus metoprolol)." | 5.11 | Blood pressure control, drug therapy, and kidney disease. ( Agodoa, LY; Cheek, D; Contreras, G; Dowie, D; Greene, T; Junco, G; Lash, J; Lipkowitz, M; Miller, ER; Ojo, A; Sika, M; Toto, RD; Wilkening, B, 2005) |
| "To study effects of fosinopril on a 24-h profile of blood pressure (BP) in hypertensive patients with obesity and hypercholesterolemia." | 5.11 | [Effects of ACE inhibitor fosinopril on a 24-h profile of arterial pressure in hypertensive patients with obesity and hypercholesterolemia]. ( Gapon, LI; Pliusnin, AV; Popova, SN; Veber, EE; Vershinina, AM, 2005) |
| "Recent studies have shown that hyperhomocysteinemia might play a role in the pathogenesis of hypertension." | 5.11 | Beta blocker effects on plasma homocysteine levels in patients with hypertension. ( Atar, I; Atar, IA; Aydinalp, A; Bozbaş, H; Demircan, S; Korkmaz, ME; Müderrisoğlu, H; Ozin, B; Yildirir, A, 2005) |
| "We evaluated insulin sensitivity in two groups of essential hypertensive subjects before and after treatment with either long-acting nifedipine (nifedipine-CR, Adalat CR tablets; Bayer Yakuhin, Osaka, Japan) (n = 10) or metoprolol (n = 9)." | 5.10 | Improvement of insulin sensitivity by a long-acting nifedipine preparation (nifedipine-CR) in patients with essential hypertension. ( Harano, Y; Kodama, K; Koyama, Y; Suzuki, M, 2002) |
| "An open, comparative, cross-over 8-week trial of beta-blockers nebivolol and metoprolol in 30 patients with arterial hypertension (AH) studied the office, ambulatory blood pressure and heart rate levels, endothelium-dependent vasorelaxation, endothelial NOS and NO production." | 5.10 | [Pharmacological modulation of NO synthesis in patients with arterial hypertension and endothelial dysfunction]. ( Buval'tsev, VI; Guseva, OI; Metel'skaia, VA; Nebieridze, DV; Spasskaia, MB, 2003) |
| "To compare efficacy and safety of atenolol, methoprolol and bisoprolol, as the most usable beta-blockers, in patients with isolated systolic arterial hypertension (ISAH) and concomitant diabetes mellitus (DM) and/or chronic obstructive pulmonary disease (COPD)." | 5.10 | [Efficacy and safety of different beta-blockers in patients with isolated systolic hypertension associated with diabetes mellitus and obstructive pulmonary diseases]. ( Abakumov, IuE; Batutina, AM; Kukes, VG; Mamaev, VI; Ostroumova, OD; Zykova, AA, 2003) |
| "The Telmisartan Effectiveness on Left ventricular MAss Reduction (TELMAR) trial will assess the effect of the angiotensin II (Ang II) receptor blocker, telmisartan, on left ventricular hypertrophy (LVH) compared with the b-blocker, metoprolol, at similar antihypertensive doses." | 5.10 | Reduction (TELMAR) as assessed by magnetic resonance imaging in patients with mild-to-moderate hypertension--a prospective, randomised, double-blind comparison of telmisartan with metoprolol over a period of six months rationale and study design. ( Dahlöf, B; Dietz, R; Friedrich, MG; Knecht, M; Sechtem, U; Unger, T, 2003) |
| "To compare efficacy and safety of nifedipin-retard (cordaflex-retard, Egis, Hungary) used in monotherapy and in combination with metoprolol (egilok, Egis, Hungary) in patients with arterial hypertension (AH)." | 5.10 | [Assessment of the efficacy and tolerance of delayed-action nifedipine as the monotherapy or in combination with metoprolol in patients with arterial hypertension]. ( Andreeva, GF; Dmitrieva, NA; Gorbunov, VM; Isaĭkina, OIu; Martsevich, SIu, 2003) |
| "We describe the effect of controlled-release/extended-release (CR/XL) metoprolol succinate once daily on mortality and hospitalizations among patients with a history of hypertension complicated by chronic systolic heart failure." | 5.10 | Effects of metoprolol CR/XL on mortality and hospitalizations in patients with heart failure and history of hypertension. ( Denny, M; Fenster, P; Herlitz, J; Heywood, T; Masszi, G; Rasmussen, S; Thorgeirsson, G; Wachtell, K; Wikstrand, J, 2002) |
| "In this multicentre, double-blind, parallel-group study, 120 out-patients with mild to moderate primary hypertension were randomised, after a 4-week single-blind placebo run-in period, to a combination tablet of felodipine-metoprolol 5/50 mg (Logimax, Mobloc, Astra) once daily or enalapril 10 mg once daily." | 5.09 | Improved efficacy with maintained tolerability in the treatment of primary hypertension. Comparison between the felodipine-metoprolol combination tablet and monotherapy with enalapril. Swedish Multicentre Group. ( Andersson, OK, 1999) |
| "Out of 245 randomized outpatients (90 men, 155 women) with uncomplicated mild-to-moderate primary hypertension and mean sitting diastolic blood pressure (DBP) 95-115 mmHg inclusive, 212 (102 on felodipine-metoprolol, 110 on amlodipine) were eligible for analysis." | 5.09 | Ambulatory 24-h blood pressure assessment of the felodipine-metoprolol combination versus amlodipine in mild to moderate hypertension. Lorraine General Physician Investigators Group. ( Boivin, JM; Zannad, F, 1999) |
| " The study was conducted on 10 patients of both sexes with mild to severe essential hypertension, aged 28 to 76 years, with normal hepatic and renal function and phenotyped as extensive metabolizers of debrisoquine (urine debrisoquine to 4-hydroxydebrisoquine ratios of 0." | 5.09 | Enantioselectivity in the steady-state pharmacokinetics of metoprolol in hypertensive patients. ( Cerqueira, PM; Cesarino, EJ; Lanchote, VL; Mateus, FH; Mere, Y; Santos, SR, 1999) |
| " Patients with uncomplicated essential hypertension (diastolic blood pressure between 95 and 110 mm Hg at the end of a 4-week run-in period) were randomly allocated to a double-blind, 12-week treatment with either a combination tablet of felodipine and metoprolol (Logimax), 5/50 mg daily (n = 321), enalapril, 10 mg daily (n = 321), or placebo (n = 304), with the possibility of doubling the dose after 4 or 8 weeks of treatment if needed (diastolic blood pressure remaining >90 mm Hg)." | 5.09 | Felodipine-metoprolol combination tablet: a valuable option to initiate antihypertensive therapy? ( Dahlöf, B; Detry, JM; Gundersen, T; Hosie, J; Januszewicz, W; Lindström, CJ; Magometschnigg, D; Puig, JG; Safar, M; Tanser, P; Toutouzas, P; Waeber, B, 1999) |
| "Ramipril, compared with amlodipine, retards renal disease progression in patients with hypertensive renal disease and proteinuria and may offer benefit to patients without proteinuria." | 5.09 | Effect of ramipril vs amlodipine on renal outcomes in hypertensive nephrosclerosis: a randomized controlled trial. ( Agodoa, LY; Appel, L; Bakris, GL; Beck, G; Bourgoignie, J; Briggs, JP; Charleston, J; Cheek, D; Cleveland, W; Douglas, JG; Douglas, M; Dowie, D; Faulkner, M; Gabriel, A; Gassman, J; Greene, T; Hall, Y; Hebert, L; Hiremath, L; Jamerson, K; Johnson, CJ; Kopple, J; Kusek, J; Lash, J; Lea, J; Lewis, JB; Lipkowitz, M; Massry, S; Middleton, J; Miller, ER; Norris, K; O'Connor, D; Ojo, A; Phillips, RA; Pogue, V; Rahman, M; Randall, OS; Rostand, S; Schulman, G; Smith, W; Thornley-Brown, D; Tisher, CC; Toto, RD; Wright, JT; Xu, S, 2001) |
| "The effects of celiprolol 200 mg or 400 mg once daily on blood pressure (BP), serum lipids, plasma fibrinogen and airways function was compared with the effects of metoprolol 100 mg or 200 mg once daily in 171 patients with mild to moderate hypertension and coexistent hyperlipidaemia in a double-blind, multicentre study lasting 1 year." | 5.08 | Effect of celiprolol and metoprolol on lipids, fibrinogen and airways function in hyperlipidaemic hypertensives: a randomised double-blind long-term parallel group trial. ( Feely, J; Holden, RD; Johnston, GD; Radley, DR; Vyssoulis, G, 1995) |
| " Twenty five unmedicated patients with primary hypertension were randomised to initial therapy with either the calcium antagonist, felodipine, or a diuretic and doses titrated to achieve similar levels of blood pressure (BP)." | 5.08 | Assessment of effects of two anti-hypertensive regimens on overall cardiovascular risk. ( Jennings, GL; Korner, P; Laufer, E; Reid, C; Sudhir, K, 1995) |
| "The efficacy and tolerability of controlled-release metoprolol (metoprolol CR/ZOK), 100-200 mg, and atenolol, 50-100 mg, once daily was compared in Chinese patients with mild to moderate essential hypertension." | 5.08 | A double-blind comparison of once-daily metoprolol controlled-release and atenolol in the treatment of Chinese patients with mild to moderate hypertension. ( Chen, MF; Chen, WJ; Lee, CM; Lee, YT; Liau, CS; Wu, CC; Yang, CY, 1995) |
| "The effects on blood pressure (BP) and heart rate (HR), at rest and during bicycle exercise, of the vascular selective calcium antagonist felodipine, the cardio-selective beta-blocker metoprolol, and of the two drugs in combination, were assessed in a double-blind, three-way cross-over study comprising 23 patients with essential, mild to moderate hypertension." | 5.08 | Effects of felodipine, metoprolol and their combination on blood pressure at rest and during exercise and on volume regulatory hormones in hypertensive patients. ( Elmfeldt, DB; Gordon, RD; Klemm, SA; Tunny, TJ; Wicks, JR, 1995) |
| " In the hypertensive patients with coronary disease the authors also evaluated sympathetic activation after double-blind, placebo-controlled administration of metoprolol (100 mg/day), followed by amlodipine (10 mg/day), quinapril (20 mg/day), and amlodipine (5 mg/day) plus quinapril (10 mg/day)." | 5.08 | Power spectral analysis of heart rate in elderly hypertensive subjects with or without silent coronary disease. ( Bucca, C; Cacciafesta, M; Di Gioacchino, C; Durante, M; Fimognari, FL; Lo Verde, A; Marigliano, V; Monteforte, G; Munizzi, MR; Piccirillo, G; Santagada, E; Tarantini, S; Viola, E, 1996) |
| "The effects of perindopril and metoprolol on left ventricular hypertrophy (LVH) and function were studied in 47 essential hypertensive patients with LVH." | 5.08 | Effect of perindopril and metoprolol on left ventricular hypertrophy and performance in essential hypertension. ( Chen, X; Dai, Z; Hui, Y; Wang, W, 1995) |
| "To study the relationship between insulin sensitivity and sodium-lithium countertransport (Na(+)-Li+ CT) in mild, essential hypertension, and to investigate the effect of metformin and metoprolol, respectively." | 5.08 | Relationship between sodium-lithium countertransport and insulin sensitivity in mild hypertension. ( Herlitz, H; Landin, K; Widgren, B, 1996) |
| " Therefore, we carried out a randomized, double-blind study to compare the effects of losartan (50 mg QD) and metoprolol (95 mg QD) on insulin sensitivity, insulin secretion, glucose tolerance, and lipids and lipoproteins in 20 hyperinsulinemic subjects with essential hypertension." | 5.08 | Effects of losartan on insulin sensitivity in hypertensive subjects. ( Karjalainen, L; Laakso, M; Lempiäinen-Kuosa, P, 1996) |
| "Metoprolol and carvedilol are widely used in the treatment of hypertension, but no randomized comparison of their hemodynamic activity has been previously reported." | 5.08 | Comparison of the hemodynamic effects of metoprolol and carvedilol in hypertensive patients. ( Bohmeke, T; Taylor, SH; van der Does, R; Weber, K, 1996) |
| "26 patients with hypertension while on hemodialysis or continuous ambulatory peritoneal dialysis for end-stage renal diseases were treated first with enalapril and then changed to metoprolol." | 5.08 | A comparison of the effect of enalapril and metoprolol on renal function, potassium balance, lipid profile, cardiac function, exercise tolerance and quality of life in hypertensive dialysis patients. ( Lai, KN; Lam, WK; Li, KT; Lui, SF; Nicholls, MG; Wong, KC; Woo, KS, 1995) |
| "To evaluate the effect of metoprolol on insulin sensitivity and diurnal plasma hormone levels, seven mildly hypertensive subjects were investigated (four men and three women, age 52 +/- 8, body mass index 25." | 5.08 | The effect of metoprolol treatment on insulin sensitivity and diurnal plasma hormone levels in hypertensive subjects. ( Attvall, S; Bengtsson, BA; Elam, M; Fowelin, J; Gudbjörnsdóttir, S; Lönnroth, P; Mårin, P, 1997) |
| "In 102 cases of severe hypertension (DBP > or = 115 mm Hg), with or without acute complications, efficacy and safety of SL Nifedipine 10 mg (NIF), SL Captopril 25 mg (CAP), IV Metoprolol 15 mg (MET) and SL NIF + IV MET were studied in an inpatient trial." | 5.08 | Nifedipine, captopril, metoprolol and nifedipine with metoprolol in hypertensive crisis in non-intensive care setting. ( Bhatt, AD; Dadkar, VN; Kapadia, NM; Karnik, ND; Khokhani, RC; Trivedi, TH; Vaidya, AB, 1996) |
| "To compare the long-term effects of the angiotensin-converting enzyme (ACE)-inhibitor quinapril and the cardioselective beta-adrenergic blocking agent metoprolol on glycaemic control, with glycosylated haemoglobin (HbA1c) as the principal variable, in non-insulin-dependent diabetes mellitus (NIDDM) patients with hypertension." | 5.08 | Comparison of effects of quinapril and metoprolol on glycaemic control, serum lipids, blood pressure, albuminuria and quality of life in non-insulin-dependent diabetes mellitus patients with hypertension. Swedish Quinapril Group. ( Asplund, K; Bystedt, T; Dahlöf, B; Jern, S; Kjellström, T; Lithell, H; Ostman, J, 1998) |
| "This study compared the antihypertensive efficacy and tolerability of a combination tablet containing the vascular-selective calcium antagonist felodipine and the beta1-selective adrenergic antagonist metoprolol, with a combination tablet of captopril-hydrochlorothiazide in a randomized, double-blind trial involving 109 patients with mild to moderate hypertension." | 5.08 | Combination therapy with felodipine and metoprolol compared with captopril and hydrochlorothiazide. German MC Study Group. ( Klein, G, 1998) |
| "Ninty patients with mild to moderate essential hypertension (EH) were randomly divided into three groups and treated with Enalapril (E), Metoprolol (M) and Nifedipine (N) respectively." | 5.08 | [Effect of antihypertensive agents on plasma endothelin, nitric oxide and so on in essential hypertension]. ( Chen, S; Liu, G; Yang, T, 1997) |
| "This study investigated the effects of an osmotic release oral drug delivery system of metoprolol on the changes induced by cumulative doses of inhaled salbutamol on bronchomotor tone, skeletal muscle, and the circulatory system after single (day 1) and multiple (day 7) dosing in 18 hypertensive asthmatic patients (forced expiratory volume in 1 second > 50% predicted; diastolic blood pressure > 90 mm Hg)." | 5.07 | Osmotic release oral drug delivery system of metoprolol in hypertensive asthmatic patients. Pharmacodynamic effects on beta 2-adrenergic receptors. ( Bauer, K; Kaik, B; Kaik, G, 1994) |
| "Central nervous system (CNS)-related symptoms and quality of life during treatment with controlled-release (CR) metoprolol and a standard formulation of atenolol were compared in a double-blind crossover study in 60 patients with mild to moderate hypertension." | 5.07 | Effects of 100 mg of controlled-release metoprolol and 100 mg of atenolol on blood pressure, central nervous system-related symptoms, and general well being. ( Albrektsen, T; Dimenäs, E; Olofsson, B; Walle, PO; Westergren, G, 1994) |
| "The authors assessed in 20 subjects with mild or medium severe arterial hypertension basal and stimulated values of plasma renin activity (PRA) and aldosterone before onset of treatment and after 6-week therapy with enalapril (ENAP KRKA) or metoprolol (Vasocardin Slovakofarma)." | 5.07 | [The importance of studying the renin-angiotensin-aldosterone system in essential arterial hypertension in clinical practice. Activity of the renin-angiotensin-aldosterone system during treatment of hypertension with ACE-inhibitors and beta blockers]. ( Chamulová, M; Hrnciar, J; Hrnciarová, M; Kreze, A; Lepej, J; Okálová, D, 1994) |
| "To compare the effects of treatment with nicardipine and metoprolol in patients with hypertension during pregnancy." | 5.07 | Nicardipine versus metoprolol in the treatment of hypertension during pregnancy: a randomized comparative trial. ( Carbonne, B; Jannet, D; Milliez, J; Sebban, E, 1994) |
| "In a randomized double-blind crossover study in 42 patients with essential hypertension, the metabolic effects of a beta-adrenergic blocker with a pronounced beta 2-agonistic effect, dilevalol 400 mg x 1, were compared with those of metoprolol succinate 200 mg x 1." | 5.07 | Treatment with a beta-blocker with beta 2-agonism improves glucose and lipid metabolism in essential hypertension. ( Haenni, A; Lithell, H, 1994) |
| "The effects of isradipine (Lomir, CAS 75695-93-1) and metoprolol (CAS 37350-58-6) on geometry and arterial compliance of the arteria brachialis of 14 patients each with essential hypertension were compared acutely and after three months of therapy by means of pulsed Doppler sonography and the determination of pulse wave velocity." | 5.07 | [Vasoselective, substance-specific actions of isradipine on the great arteries of hypertensives in comparison to metoprolol]. ( Bräutigam, M; Burger, KJ; Del Pino, M; Levenson, J; Merli, I; Simon, A; Welzel, D, 1994) |
| "This study compared with placebo the efficacy and tolerability of optimised doses of felodipine 5-20 mg daily, metoprolol 50-200 mg daily and their combination in subjects 60 years or over with isolated systolic hypertension." | 5.07 | Felodipine, metoprolol and their combination compared with placebo in isolated systolic hypertension in the elderly. ( Bune, AJ; Chalmers, JP; Russell, AE; Tonkin, AL; West, MJ; Wing, LM, 1994) |
| " In a randomized double-blind study, the effect of lisinopril and metoprolol on arterial distensibility was studied in 40 patients with essential hypertension." | 5.07 | Effect of lisinopril and metoprolol on arterial distensibility. ( Barenbrock, M; Hoeks, AP; Rahn, KH; Spieker, C; Zidek, W, 1994) |
| "The effects of isradipine and metoprolol were studied on the brachial arteries of two groups of 14 patients with hypertension, 90 minutes after the first dose and after 3 months of treatment." | 5.07 | Intrinsic effect of antihypertensive treatment with isradipine and metoprolol on large artery geometric and elastic properties. ( Brautigam, M; Del Pino, M; Levenson, J; Merli, I; Simon, A; Welzel, D, 1993) |
| "The authors compared the relative safety and efficacy of changing treatment from once-daily atenolol to metoprolol in patients with essential hypertension." | 5.07 | A comparison of once-daily atenolol and metoprolol using office and ambulatory blood pressure monitoring. ( Brady, EM; Feig, PU; Kriegman, AG; May, S; Rutan, GH, 1993) |
| "Fifty patients with mild or moderate hypertension were assessed for the influence on peripheral hemodynamics of 10 months of treatment with lisinopril (25 patients) or metoprolol (25 patients)." | 5.07 | Forearm arterial distensibility in patients with hypertension: comparative effects of long-term ACE inhibition and beta-blocking. ( Andriani, A; Bonfantino, MV; De Cesaris, R; Filitti, V; Ranieri, G, 1993) |
| "Obesity affects the efficacy of metoprolol and isradipine in reducing blood pressure." | 5.07 | Obesity as a determinant for response to antihypertensive treatment. ( Gatzka, C; Rüddel, H; Schächinger, H; Schmieder, RE; Schobel, H, 1993) |
| "The antianginal activities of nicorandil, 10 and 20 mg bid, and metoprolol, 100 mg bid, were compared in patients with stable effort angina pectoris in a randomized, double-blind parallel group study lasting 7 weeks." | 5.07 | A double-blind comparison of nicorandil and metoprolol in stable effort angina pectoris. ( Bokor, D; Carotenuto, A; de Divitiis, M; de Divitiis, O; Di Somma, S; Liguori, V; Petitto, M, 1993) |
| "The plasma drug concentration-effect relationship after an oral dose of 100 mg metoprolol has been studied in 8 women in the third trimester of a pregnancy complicated by hypertension." | 5.07 | Plasma concentration-effect relationship of metoprolol during and after pregnancy. ( Högstedt, S; Rane, A, 1993) |
| "The effects of long-term treatment with captopril and conventional therapy on albuminuria and metabolic parameters were compared in 74 hypertensive type II diabetics with normal serum creatinine." | 5.07 | Captopril or conventional therapy in hypertensive type II diabetics. Three-year analysis. ( Lacourcière, Y; Nadeau, A; Poirier, L; Tancrède, G, 1993) |
| "The effects of the calcium antagonist isradipine and the beta-blocker metoprolol, which are based on different antihypertensive therapeutic principles, were evaluated in 52 men with mild-to-moderate hypertension in a 6-week, double-blind, randomized study." | 5.07 | Pharmacological modulation of stress-induced cardiovascular hyperreactivity in essential hypertension. ( Bräutigam, M; Rüddel, H; Schächinger, H; Schmieder, R; Schulte, W; Welzel, D, 1992) |
| "Twenty patients whose systemic hypertension was not controlled with chronic beta-blocker therapy were studied to evaluate the acute (first dose), short-term (4 weeks) and chronic (6 to 12 months) effects of the calcium antagonist felodipine on blood pressure (BP), left ventricular (LV) anatomy and function and on plasma norepinephrine." | 5.07 | Antihypertensive effect of felodipine associated with persistent sympathetic activation and minimal regression of left ventricular hypertrophy. ( Holliwell, DL; Leenen, FH, 1992) |
| "In a double-blind, randomized trial with 26 male white patients with essential hypertension in World Health Organization Stages I and II, we examined the impact of calcium entry blockade (5 to 10 mg/day isradipine, N = 14) and beta-blockade (100 to 200 mg/day metoprolol, N = 12) on early markers of hypertensive nephropathy before and after 7 weeks' treatment." | 5.07 | Impact of antihypertensive therapy with isradipine and metoprolol on early markers of hypertensive nephropathy. ( Rockstroh, J; Rüddel, H; Schächinger, H; Schlebusch, H; Schmieder, RE; Schulte, W, 1992) |
| "To assess the short-term efficacy and safety of metoprolol in the treatment of hypertension in a large population of older patients." | 5.07 | Safety and efficacy of metoprolol in the treatment of hypertension in the elderly. ( Glasser, S; LaPalio, L; Schork, A; Tifft, C, 1992) |
| "The antihypertensive effect of captopril, metoprolol, and hydrochlorothiazide was compared in 23 non-insulin-dependent (NIDDM) diabetic patients less than or equal to 75 years of age, with borderline to moderate primary hypertension." | 5.07 | Placebo-controlled comparison of captopril, metoprolol, and hydrochlorothiazide therapy in non-insulin-dependent diabetic patients with primary hypertension. ( Beck-Nielsen, H; Faergeman, O; Gall, MA; Gerdes, LU; Hommel, E; Lauritzen, M; Mathiesen, ER; Rossing, P; Skøtt, P; Vølund, A, 1992) |
| "4 years) with mild or moderate essential hypertension (WHO groups I or II) to find out whether an 8-week antihypertensive treatment with daily 10-20 mg enalapril or 100-200 mg metoprolol changed their exercise performance." | 5.07 | [Exercise performance after long-term administration of enalapril or metoprolol. A randomized double-blind study of hypertensive leisure-time sportsmen]. ( Billigmann, PW; Bohner, H; Schumacher, H; Teixeira, A, 1992) |
| "In a double-blind, crossover study, five white men with mild-to-moderate hypertension received placebo and fixed doses of atenolol, metoprolol, chlorthalidone, verapamil, and the combination of atenolol and chlorthalidone in a quasi-random order." | 5.07 | Effectiveness of antihypertensive medications in office and ambulatory settings: a placebo-controlled comparison of atenolol, metoprolol, chlorthalidone, verapamil, and an atenolol-chlorthalidone combination. ( Durel, LA; Hayashi, PJ; Schneiderman, N; Weidler, DJ, 1992) |
| "The authors investigated the effectiveness of treatment of hypertension by monotherapy with beta-blockers--bopindolol (a beta-blocker with a slightly expressed ISA) and metoprolol (cardioselective beta-blocker) in 86 subjects with mild and medium severe hypertension." | 5.07 | [Beta-blockers in the treatment of hypertension in elderly patients]. ( Lefflerová, K; Lupínek, Z; Widimský, J, 1991) |
| "General well-being, adverse effects and anti-hypertensive efficacy have been investigated in a double blind, parallel-group, dose-response multicentre study of diltiazem and metoprolol monotherapy for hypertension." | 5.07 | Effects of diltiazem and metoprolol on blood pressure, adverse symptoms and general well-being. The Swedish Diltiazem-Metoprolol Multi-Centre Study Group. ( Dahlöf, C; Gustafsson, S; Hedner, T; Olsson, SO; Thulin, T, 1991) |
| " 20 of them suffered from essential hypertension (group A) and were treated with metoprolol with a dosage of 50 to 200 mg per day." | 5.07 | [Effect of metoprolol on microcirculation and blood viscoelasticity]. ( Eber, O; Klima, G; Költringer, P; Langsteger, W; Lind, P; Pierer, G; Reisecker, F, 1991) |
| "Sixty-two patients with mild hypertension were randomly assigned to receive no treatment, or 160 mg propranolol, or 200 mg metoprolol daily starting one week before elective surgery under anesthesia." | 5.07 | A pressor effect of noncardioselective beta blockers in mildly hypertensive patients during surgery under anesthesia. ( Asselt, LM; Cleophas, TJ; Oudshoorn, NH; Quadir, SU, 1991) |
| "In a randomized primary prevention trial including 3,234 men with mild to moderate uncomplicated hypertension, the effect of the beta-blocker metoprolol or a thiazide diuretic as an initial antihypertensive therapy was compared regarding the risk of sudden cardiovascular death during a follow-up ranging from 2." | 5.07 | Primary prevention of sudden cardiovascular death in hypertensive patients. Mortality results from the MAPHY Study. ( Barber, H; Berglund, G; Eliasson, K; Elmfeldt, D; Jastrup, B; Karatzas, N; Leer, J; Olsson, G; Tuomilehto, J; Warnold, I, 1991) |
| "In a randomized, double-blind, parallel group study, diltiazem was compared with metoprolol as add-on therapy to diuretic treatment in 115 patients with hypertension." | 5.07 | Diltiazem compared with metoprolol as add-on-therapies to diuretics in hypertension. Swedish Diltiazem-Metoprolol Multicentre Study Group. ( Gustafsson, S; Hedner, T; Olsson, SO; Thulin, T, 1991) |
| "Forty-five patients with mild hypertension were treated for 2 months with either metoprolol or pindolol in a randomized, blind, crossover study." | 5.06 | Effect of metoprolol and pindolol monotherapy on plasma lipid- and lipoprotein-cholesterol levels (including the HDL subclasses) in mild hypertensive males and females. ( Mányai, S; Mészáros, I; Molnár, M; Rischák, K; Szollár, LG; Tornóci, L, 1990) |
| "Carvedilol, a beta-blocking drug with vasodilator activity, has been used in 4 studies in 107 elderly patients with essential hypertension and has reduced blood pressure effectively." | 5.06 | The use of carvedilol in elderly hypertensive patients. ( Adam, W; Anderson, A; Cripps, J; Morgan, TO, 1990) |
| "In two separate but similarly designed placebo-controlled studies, the efficacy of metoprolol CR/ZOK 50 mg once daily was evaluated in 64 patients (mean age 53 years) with mild hypertension (Study I) and in 34 elderly patients (mean age 68 years) with mild to moderate hypertension (Study II)." | 5.06 | The efficacy of low dose metoprolol CR/ZOK in mild hypertension and in elderly patients with mild to moderate hypertension. ( Baandrup, S; Houtzagers, J; Jäättelä, A; Westergren, G, 1990) |
| "In a double-blind study with parallel groups, the clinical bioequivalence of the antihypertensive effect of metoprolol CR/ZOK (controlled release formulation) 50 mg and atenolol 50 mg in ordinary tablets given once daily for uncomplicated hypertension was investigated." | 5.06 | A double-blind comparison of metoprolol CR/ZOK 50 mg and atenolol 50 mg once daily for uncomplicated hypertension. ( Berger, J; Klein, G; Menzel, T; Olsson, G, 1990) |
| "We studied the effect of phenylpropanolamine on blood pressures in seven patients whose hypertension was controlled with beta blockers." | 5.06 | The effect of single-dose phenylpropanolamine on blood pressure in patients with hypertension controlled by beta blockers. ( Gross, CR; O'Connell, MB, 1990) |
| "We assessed the efficacy of long-acting nifedipine as monotherapy in 52 patients with mild to moderate essential hypertension in a randomized, controlled crossover study." | 5.06 | Long-acting nifedipine versus metoprolol as monotherapy for essential hypertension. A randomized, controlled crossover study. ( Pun, CO; Woo, KS, 1990) |
| "A double-blind controlled, randomized, parallel, multicenter 12-week study was conducted to compare the antihypertensive efficacy of lisinopril with that of metoprolol in treatment of moderate to severe hypertension." | 5.06 | Evaluation of antihypertensive efficacy of lisinopril compared to metoprolol in moderate to severe hypertension. ( Bonnet, G; Chrysant, SG; DeBacker, G; Goldstein, R; Herrera, J; Lindner, A; Materson, BJ; Maxwell, MH; McMahon, FG; Zachariah, PK, 1987) |
| "Carvedilol and metoprolol were given for 4 weeks in a double-blind study to patients with essential hypertension." | 5.06 | Effect of carvedilol and metoprolol on blood pressure, blood flow, and vascular resistance. ( Butcher, L; Morgan, T; Snowden, R, 1987) |
| "60 Patients with primary hypertension (diastolic blood pressure when resting supine 95-119 mm Hg on at least two occasions during four to six weeks of treatment with placebo) randomised to receive either metoprolol (n = 30) or atenolol (n = 30) during the first treatment period." | 5.06 | Sensitivity to insulin during treatment with atenolol and metoprolol: a randomised, double blind study of effects on carbohydrate and lipoprotein metabolism in hypertensive patients. ( Berne, C; Lithell, H; Pollare, T; Selinus, I, 1989) |
| "The question whether initial antihypertensive treatment with a beta-blocker prevents hypertensive complications better than initial treatment with a non-betablocker, mainly diuretic based treatment, has been studied in recent large-scale studies like the Medical Research Council (MRC) trial, the International Prospective Primary Prevention Study in Hypertension (IPPPSH), the Heart Attack Primary Prevention in Hypertension (HAPPHY) study and the Metoprolol Atherosclerosis Prevention in Hypertensives (MAPHY) study." | 5.06 | Beta-blockers and diuretics. The HAPPHY and MAPHY studies. ( Berglund, G, 1989) |
| "The article presents the experience gained with a new betablocker- bopindolol-in the treatment of hypertension." | 5.06 | Bopindolol in the treatment of hypertension: a double blind study comparing bopindolol and metoprolol. ( Lefflerová, K; Lupínek, Z; Lupínková, Z; Miklis, P; Uhlír, O; Widimský, J; Zeman, K; Zicha, J, 1989) |
| "A material of 76 patients from general practice treated with diuretics for mild to moderate hypertension were randomized to supplementary treatment with captopril (39 patients) and metoprolol (37 patients), respectively, on account of diastolic blood pressure greater than or equal to 95 mmHg." | 5.06 | [The effects of captopril and metoprolol on blood pressure and side effects in patients with mild to moderate hypertension]. ( Kornerup, HJ; Korsager, S, 1989) |
| " Aim of this work was to evaluate the influence of obesity on the kinetics and the antihypertensive effect of two Beta-blockers with different solubility such as: the water-soluble, atenolol and the liposoluble, metoprolol." | 5.06 | Obesity and beta-blockers: influence of body fat on their kinetics and cardiovascular effects. ( Fasano, ML; Ferrara, LA; Galletti, F; Groppi, A; Mancini, M; Montagna, M, 1989) |
| "The safety and efficacy of step-one therapy with enalapril, a new angiotensin-converting enzyme inhibitor, and metoprolol were compared in a double-blind, multicenter study involving 150 patients who had mild to moderate essential hypertension." | 5.06 | A comparison of enalapril and metoprolol as initial therapy for mild to moderate hypertension. ( Miola, SR; Nugent, LW; Walker, JF, 1987) |
| "Single and combined therapy with terbutaline (10 mg/day) and metoprolol (200 mg/day) and single therapy with orciprenaline (30 mg/day) were assessed over 8 weeks in a total of 45 patients with essential hypertension." | 5.06 | Combined beta 1-adrenoceptor blockade and/or beta 2- or beta 1/2 adrenoceptor stimulation as treatment of essential hypertension. ( Gotzen, R; Meyer-Sabellek, W; Röcker, L; Schulte, KL; Thiede, HM, 1988) |
| "The blood pressure of patients with hypertension who were aged between 60 and 75 years responded equally well to treatment with metoprolol (100 mg a day) or hydrochlorothiazide (25 mg a day) in a double-blind study which employed random allocation to two parallel groups." | 5.06 | Metoprolol or hydrochlorothiazide in patients with hypertension aged 60-75 years. With special reference to assessment of compliance. Hunter Hypertension Research Group. ( , 1986) |
| "The effects of long-term (6 months) antihypertensive treatment with three different types of beta-blockers (propranolol, nonselective without ISA; pindolol, nonselective with ISA; metoprolol, beta 1-selective without ISA) on submaximal exercise capacity and metabolic variables during submaximal endurance exercise were studied in seven subjects with essential hypertension." | 5.06 | Long-term antihypertensive therapy with beta-blockers: submaximal exercise capacity and metabolic effects during exercise. ( Arends, BG; Böhm, RO; Rahn, KH; van Baak, MA; van Hooff, ME, 1987) |
| "We compared the effects of weight reduction, metoprolol, and placebo on M-mode echocardiographic measurements of the thickness and mass of the left ventricular wall in a 21-week, randomized controlled trial that enrolled 41 young, overweight patients with hypertension." | 5.06 | The effect of weight reduction on left ventricular mass. A randomized controlled trial in young, overweight hypertensive patients. ( Macdonald, GJ; MacMahon, SW; Wilcken, DE, 1986) |
| "The long-term safety and efficacy of ketanserin in the treatment of essential hypertension was assessed in monotherapy or in combination with the beta-blocker, metoprolol." | 5.06 | Long-term safety and efficacy of ketanserin in essential hypertension: ketanserin versus or in combination with metoprolol. ( Mauersberger, H, 1986) |
| "Ketanserin (K), a selective and specific S2-receptor antagonist, has been compared with metoprolol (M), a cardioselective beta-blocker, in a double-blind study in order to assess its efficacy and safety in the treatment of essential hypertension." | 5.06 | Clinical experience with ketanserin in the treatment of hypertension. ( Assogna, G; Costantini, C; del Rosso, G; Libretti, A; Mara, G; Palermo, A; Pizza, N, 1986) |
| "Doxazosin is a long-acting selective alpha 1-adrenoceptor antagonist which has been shown to be effective and well tolerated in the treatment of hypertension given in once-daily doses as monotherapy for up to 1 year or as an adjunct to thiazide or beta-adrenoceptor blockers." | 5.06 | The antihypertensive effects of doxazosin: a clinical overview. ( Cox, DA; Leader, JP; Milson, JA; Singleton, W, 1986) |
| "Weight reduction was compared with metoprolol (200 mg daily) in a randomized placebo-controlled trial of first-line treatment of mild hypertension (diastolic blood pressure 90-109 mm Hg) in 56 overweight patients aged under 55 years." | 5.06 | Treatment of high blood pressure in overweight patients. ( Macdonald, G; MacMahon, S, 1987) |
| "In a 4-week randomized, double-blind study, 87 patients with essential hypertension received either 10 mg bisoprolol (B) or 100 mg metoprolol (M) once daily (o." | 5.06 | Exercise blood pressure and heart rate reduction 24 and 3 hours after drug intake in hypertensive patients following 4 weeks of treatment with bisoprolol and metoprolol: a randomized multicentre double-blind study (BISOMET). ( Bethge, H; Haasis, R, 1987) |
| "Ten patients with uncomplicated moderate essential hypertension were recruited to evaluate the effect of the non-selective beta-blocker propranolol and the beta 1-selective beta-blocker metoprolol on platelet aggregation and cAMP formation." | 5.06 | Effect of metoprolol and propranolol on platelet aggregation and cAMP level in hypertensive patients. ( Gormsen, J; Jensen, J; Knudsen, JB; Winther, K, 1986) |
| "To compare responses of blood pressure to the calcium antagonist verapamil and the beta blocker metoprolol in black compared with white diabetics with hypertension and to monitor urinary albumin excretion in relation to fall in blood pressure." | 5.06 | Treating hypertension in black compared with white non-insulin dependent diabetics: a double blind trial of verapamil and metoprolol. ( Anderson, NM; Cruickshank, JK; Jepson, E; Wadsworth, J; Young, SM, 1988) |
| "Atenolol and metoprolol are the two most widely used beta 1-adrenoceptor antagonists in the treatment of essential hypertension." | 5.06 | No difference in general well-being during antihypertensive treatment with atenolol or metoprolol CR. ( Almkvist, G; Dahlöf, C; Dimenäs, E; Jern, S; Johansson, B; Larsson, C; Lorentzon, S; Nilsson, D; Nygaard-Pedersen, L, 1988) |
| "A randomized controlled, single-blind trial was conducted to compare the effectiveness of a high-dose diuretic with a combination of a diuretic and metoprolol in black adults with hypertension." | 5.06 | Diuretics and hypertension in black adults. ( Dieckmann, MR; Hawkins, DW; Horner, RD, 1988) |
| "The outcome of postinfarction patients with a history of hypertension who participated in a randomized, double-blind, secondary prevention study with metoprolol or placebo treatment for 3 years has been evaluated." | 5.06 | Thromboatherosclerotic complications in hypertensives: results of the Stockholm Metoprolol (secondary prevention) Trial. ( Olsson, G, 1988) |
| " The present double-blind placebo-controlled randomized long-term study reports the therapeutic results of the oral administration of a new beta-adrenergic blocking agent, carvedilol, with direct vasodilator activity in patients with primary hypertension." | 5.06 | Follow-up of a method of twenty-four-hour indirect blood pressure monitoring: evaluation of carvedilol, a new antihypertensive agent. ( Distler, A; Gotzen, R; Meyer-Sabellek, W; Schulte, KL, 1987) |
| "Single and combined therapy with terbutaline (10 mg/day) and metoprolol (200 mg/day) was assessed over 8 weeks in a double-blind parallel study in a total of 36 patients with essential hypertension grade I-II according to WHO criteria at rest and during exercise." | 5.06 | Beta-adrenoceptor stimulating and blocking agents in essential hypertension: single and combined therapy with terbutaline and metoprolol. ( Gotzen, R; Meyer-Sabellek, W; Röcker, L; Schulte, KL; Thiede, HM, 1987) |
| "In a double-blind study with parallel groups a new controlled-release (CR) formulation of metoprolol, 100 mg once daily, was compared with conventional metoprolol tablets, 100 mg once daily, in 27 patients with primary hypertension." | 5.06 | Effect of controlled-release metoprolol on blood pressure and exercise heart rate in hypertension: a comparison with conventional tablets. ( Kristensson, BE; Rydén, L; Westergren, G, 1988) |
| "The effects of acebutolol (with intrinsic sympathomimetic activity (ISA] and metoprolol (without ISA) on arm blood pressure, ankle systolic blood pressure, claudication distances (CD) and maximal walking distances (MWD) were compared in patients with essential hypertension and intermittent claudication." | 5.06 | The effects of acebutolol and metoprolol on walking distances and distal blood pressure in hypertensive patients with intermittent claudication. ( Jelnes, R; Svendsen, TL; Tønnesen, KH, 1986) |
| "The Stockholm Metoprolol Trial is a prospective double-blind placebo-controlled postmyocardial infarction study of 301 patients treated with metoprolol, 100 mg b." | 5.06 | Reduction of nonfatal reinfarctions in patients with a history of hypertension by chronic postinfarction treatment with metoprolol. ( Olsson, G; Rehnqvist, N, 1986) |
| "The hypertensive effect of urapidil, a new antihypertensive agent that acts via central and peripheral alpha-adrenoceptors, has been compared with that of metoprolol in 40 patients with mild essential hypertension." | 5.06 | Comparison of the antihypertensive effect of urapidil and metoprolol in hypertension. ( Boni, S; Guffanti, E; Leonetti, G; Mazzola, C; Meani, A; Zanchetti, A, 1986) |
| "Monotherapy with Ketanserin, a serotonin receptor antagonist, reduces blood pressure in a sizeable number of patients with essential hypertension." | 5.06 | Ketanserin in the treatment of essential hypertension. A double-blind study against metoprolol and a further long-term open treatment. ( Bernardiner, E; Lemus, J; Milei, J, 1986) |
| "Ketanserin, a serotonin receptor antagonist (S2), lowered blood pressure in patients with essential hypertension; at three months 72% (13/18) had a successful reduction in pressure." | 5.06 | Comparison of ketanserin and metoprolol in the treatment of essential hypertension. ( Agerter, DC; Araas, FJ; Collins, JB; Fisher, LD; Schirger, A; Sheps, SG; Spiekerman, RE; Zachariah, PK, 1987) |
| "Thirty-two patients with mild to moderate essential hypertension completed this double-blind cross-over clinical trial of propranolol and metoprolol." | 5.06 | Double-blind, randomized, cross-over clinical trial of metoprolol and propranolol in mild to moderate essential hypertension. ( Pandhi, P; Sahai, J; Sharma, BK; Sharma, PL; Wahi, PL, 1987) |
| "The effect of 2 weeks treatment with propranolol or metoprolol on skin blood flow (SBF) at rest was examined in 12 diabetic patients with essential hypertension in whom gross large vessel disease had been excluded." | 5.06 | The effects of propranolol and metoprolol on skin blood flow in diabetic patients. ( Barham, J; Hyer, SL; Shaw, J; Taylor, D; Vince, FP; Wilson, J, 1987) |
| "In a double-blind, comparative study metoprolol (100 to 300 mg/day) or pindolol (5 to 15 mg/day) was given in randomized order to 39 patients with uncomplicated essential hypertension." | 5.06 | Hemodynamics of metoprolol and pindolol in systemic hypertension with particular reference to reversal of structural vascular changes. ( Hansson, L, 1986) |
| "Women with previously untreated arterial hypertension have been followed up during ten years of beta-blocker treatment, first for three years with alprenolol and then for seven years with the selective beta1-blocker metoprolol." | 5.05 | Seven years on a selective beta-blocker - metoprolol. A long-term study of women with arterial hypertension. ( Bengtsson, C, 1981) |
| "Twenty-five patients with moderate essential hypertension (standing diastolic blood pressure 100-125 mmHg, phase 5) completed a single-blind placebo-controlled cross-over study comparing four week periods of treatment with atenolol 100 mg, metoprolol 100 mg, metoprolol durules 200 mg, slow-release oxprenolol 160 mg, and slow-release oxprenolol 320 mg respectively." | 5.05 | Comparative study of atenolol, metoprolol, metoprolol durules, and slow-release oxprenolol in essential hypertension. ( Hampton, JR; Wilcox, RG, 1981) |
| "Two beta-blocking agents, non-selective propranolol and beta1-selective metoprolol, were investigated with respect to their effects on glucose metabolism in 10 hypertensive patients with non-insulin dependent diabetes mellitus (NIDDM)." | 5.05 | Influence of beta-blocking drugs on glucose metabolism in patients with non-insulin dependent diabetes mellitus. ( Gordin, A; Groop, L; Harno, K; Tötterman, KJ, 1982) |
| "The mechanisms of the changes in plasma lipids concentrations observed after beta-blockade were examined in 53 patients with hypertension receiving treatment with atenolol, metoprolol, propranolol, and oxprenolol in a randomised cross-over trial." | 5.05 | Adrenergic mechanisms in control of plasma lipid concentrations. ( Day, JL; Metcalfe, J; Simpson, CN, 1982) |
| "1 This study was designed to compare in a randomized cross-over trial pindolol, a beta-adrenoceptor blocking agent with intrinsic sympathomimetic activity and metoprolol, a cardioselective beta-adrenoceptor blocker lacking sympathomimetic activity in hypertensives with incipient heart failure." | 5.05 | The influence of beta-adrenoceptor blockade on left ventricular function. ( Hahn, B; Strauer, BE, 1982) |
| "The effect of a four-week treatment with propranolol and metoprolol on blood pressure and regional haemodynamics of the lower extremity at rest, after exercise and during reactive hyperaemia was studied in 34 patients with essential hypertension, but without peripheral arterial disease, in a randomized placebo-controlled trial." | 5.05 | Effect of long-term beta-adrenergic-blockade on calf blood flow in hypertensive patients. ( Lepäntalo, M; Tötterman, KJ, 1983) |
| " We have studied both active renin and prorenin before and during treatment of hypertension with either nadolol or metoprolol in 44 patients." | 5.05 | Prorenin and beta-blockade in hypertension. ( Davison, AM; McKenna, F, 1983) |
| "9 years) with mild to moderate essential hypertension a comparison between equipotent beta-blocking doses of propranolol, metoprolol and labetalol was carried out." | 5.05 | Propranolol vs metoprolol vs labetalol: a comparative study in essential hypertension. ( Coote, JH; Kubik, MM, 1984) |
| "Atenolol 100 mg once daily and metoprolol SA 200 mg once daily were compared in 20 patients with mild to moderate hypertension, in a randomised, double-blind cross-over trial." | 5.05 | A comparison of once daily atenolol and metoprolol SA in mild to moderate hypertension. ( Cavalcanti, C; Morley, CA; Perrins, EJ; Sutton, R, 1983) |
| "The antihypertensive effects of oral labetalol, a new alpha- and beta-adrenergic blocking agent, and metoprolol, a relatively beta1 selective adrenergic blocker, were evaluated in 91 patients with mild to moderate hypertension (standing diastolic blood pressure of 90 to 115 mm Hg) in a double-blind parallel group multicenter clinical trial." | 5.05 | Multiclinic comparison of labetalol to metoprolol in treatment of mild to moderate systemic hypertension. ( Frishman, WH; Johnson, BF; Michelson, EL; Poland, MP, 1983) |
| "In a cross-over study of 52 middle-aged patients with mild to moderate essential hypertension, we have compared the effect and tolerability of 100 mg atenolol and 100 mg metoprolol given once daily." | 5.05 | Influence of time and physical activity on blood pressure and heart rate during treatment with beta-blocking agents once daily. ( Danielson, M; Kjellberg, J; Kuylenstierna, J; Lundkvist, L; Svensson, O, 1983) |
| "An open, randomized crossover trial was carried out in 10 patients with hypertension to compare the degree and duration of antihypertensive effect of metoprolol given as 100 mg ordinary tablets twice daily and as single daily doses of a 200 mg sustained-release tablet." | 5.05 | A comparative trial of ordinary metoprolol tablets and metoprolol sustained-release tablets in hypertensive patients at rest and on exercise. ( Kolsky, H; Moisson, P; Witchitz, S, 1984) |
| "In a placebo-controlled double-blind study 14 hypertensive patients with intermittent claudication were treated with metoprolol (100-200 mg daily) and methyldopa (500-1000 mg daily) for 3 weeks and their effects on heart rate, blood pressure as well as on resting and hyperaemic calf blood flow and vascular resistance were compared." | 5.05 | Chronic effects of metoprolol and methyldopa on calf blood flow in intermittent claudication. ( Lepäntalo, M, 1984) |
| "In a placebo-controlled double-blind crossover trial, the effect of a 3-week course of treatment with metoprolol (100-200 mg daily) and methyldopa (500-1000 mg daily) on walking capacity on a treadmill with increasing work load was studied in 14 hypertensive patients with intermittent claudication." | 5.05 | Walking capacity of patients with intermittent claudication during chronic antihypertensive treatment with metoprolol and methyldopa. ( Lepäntalo, M; von Knorring, J, 1984) |
| "The effects of once daily dosage of the two cardioselective beta-adrenoceptor blocking agents, atenolol and metoprolol, were studied in 26 patients with primary hypertension." | 5.05 | A comparison of 100 mg atenolol and 100 mg metoprolol once a day at rest and during exercise in hypertensives. ( Atterhög, JH; Castenfors, J; Jorfelt, L; Karlberg, BE; Nilsson, OR; Ohman, KP; Thulin, T; Tolagen, K; Wettre, S, 1984) |
| "The biochemical disturbance produced by thiazide diuretics and by amiloride during treatment of moderate hypertension were compared." | 5.05 | Comparison of thiazides and amiloride in treatment of moderate hypertension. ( Thomas, JP; Thomson, WH, 1983) |
| "Thirty patients with essential hypertension participated in a double blind crossover trial in which they were randomly allocated to treatment with either once daily slow release metoprolol (200 mg) with placebo or once daily slow release metoprolol (200 mg) with chlorthalidone (25 mg)." | 5.05 | Effect on intra-arterial blood pressure of slow release metoprolol combined with placebo or chlorthalidone. ( Altman, DG; Gould, BA; Hornung, RS; Kieso, HA; Mann, S; Raftery, EB, 1983) |
| "A randomized double-blind crossover trial was conducted in 20 patients with moderate to severe hypertension to compare the efficacy of labetalol, which combines alpha- and beta-adrenoceptor blocking properties, with that of metoprolol alone or in combination with prazosin." | 5.05 | On the combination of alpha- and beta-adrenoceptor blockade in hypertension. ( Gellatly, R; Hill, A; Mennie, BA; Stokes, GS, 1983) |
| "The Göteborg Metoprolol Trial was a double-blind, placebo-controlled, stratified trial aimed at evaluating the effect of the beta 1-selective blocker, metoprolol, in suspected acute myocardial infarction and during 2 years of follow-up." | 5.05 | Göteborg Metoprolol Trial: design, patient characteristics and conduct. ( Herlitz, J; Holmberg, S; Pennert, K; Swedberg, K; Vedin, A; Waagstein, F; Waldenström, A; Waldenström, J; Wedel, H; Wilhelmsen, L, 1984) |
| " This possibility has been investigated in 12 patients with hypertension by infusing increasing intravenous doses of phenylephrine after 2 wk on propranolol, metoprolol, or placebo within a randomized, double-blind, crossover study design." | 5.05 | Beta adrenoceptor antagonism and pressor response to phenylephrine. ( Myers, MG, 1984) |
| "The results of an uncontrolled and open study of a once-a-day dosage of metoprolol (Betaloc) in the management of mild to moderate hypertension are described." | 5.05 | Metoprolol for hypertension. Open trial in general practice. ( Fredman, RM, 1982) |
| "A double-blind crossover trial was undertaken to compare the efficacy of sustained-release clonidine and long-acting propranolol in the treatment of 20 patients (8 males and 12 females) with sustained hypertension." | 5.05 | Comparison of sustained-release clonidine and long-acting propranolol in the treatment of hypertension. ( Lawson, AA; Rodrigues, E, 1982) |
| "The clinical efficacy of propranolol and metoprolol slow-release tablets (Durules) was compared in 20 patients with typical angina pectoris and concomitant hypertension." | 5.05 | Metoprolol in angina pectoris complicated by essential hypertension. A clinical comparison of the antianginal efficacy of metoprolol slow-release tablets (Durules) given once daily and propranolol tablets given twice daily. ( BLoem, TJ; Lindner, PC, 1981) |
| "The effect of once-daily dosage of the two most widely prescribed cardioselective beta-adrenoceptor antagonists used to treat hypertension--namely, atenolol and metoprolol--was studied in nine carefully selected hypertensive outpatients." | 5.05 | Atenolol and metoprolol once daily in hypertension. ( Hawksworth, GM; Lovell, HG; Petrie, JC; Rigby, JW; Scott, AK; Webster, J, 1982) |
| "Intra-arterial ambulatory blood pressure was measured over 24 hours, in 34 patients with newly diagnosed hypertension, both before and after double-blind randomisation to treatment with atenolol (n=9), metoprolol (n=9), pindolol (n=9), or propranolol in its slow-release form (n=7)." | 5.05 | Ambulatory blood pressure during once-daily randomised double-blind administration of atenolol, metoprolol, pindolol, and slow-release propranolol. ( Floras, JS; Hassan, MO; Jones, JV; Sleight, P, 1982) |
| "Eighteen patients with idiopathic hypertension were studied to assess the anti-hypertensive control, both at rest and during exercise of increasing doses of hydrochlorothiazide, metoprolol and a combination of hydrochlorothiazide and metoprolol." | 5.05 | An evaluation of the effect on resting and exercise blood pressure of some first line treatments in hypertension. ( Barbour, MB; Lawrie, TD; Lorimer, AR, 1983) |
| "Five patients with moderate hypertension were given placebo and at least 3 single oral doses (25, 50, 75, 100, or 150 mg) of metoprolol as well as multiple doses at at least 2 dose levels (25, 50, or 100 mg thrice daily)." | 5.05 | Plasma levels and effects of metoprolol after single and multiple oral doses. ( Collste, P; Haglund, K; von Bahr, C, 1980) |
| "One hundred nineteen patients with essential hypertension (96 completing six months and 92 a one year study period) were randomized into four parallel groups and treated with one of four programs: 200 mg of metoprolol plus placebo; 200 mg of metoprolol plus 25 mg of hydrochlorothiazide; 200 mg of metoprolol plus 50 mg hydrochlorothiazide, or; 200 mg metoprolol plus 50 mg of hydralazine." | 5.05 | Clinical evaluation of the antihypertensive effect of metoprolol in combination with hydrochlorothiazide and hydralazine in an unselected hypertensive population. ( Honkavaara, M; Nissinen, A; Tuomilehto, J, 1980) |
| "Thirty patients with essential hypertension (WHO Stage I or II) completed a double blind crossover trial in which they received metoprolol as monotherapy as either a slow release formulation of 200 mg once daily or a conventional formulation of 100 mg bd." | 5.05 | Sustained release metoprolol: a comparison with conventional formulation in the treatment of hypertension. ( Flacks, LM; Goldstraw, PW; Kiddle, GB; Logan, RL; Watt, M, 1981) |
| "After a two-week run-in period on placebo, fifty-two patients with benign essential hypertension (WHO classes I or II) were treated with individually titrated doses of metoprolol or propranolol for 36 weeks." | 5.05 | Metoprolol and propranolol in the treatment of essential hypertension - a long-term comparative study. ( Sjöberg, KH, 1981) |
| "The effect of metoprolol, a beta1-selective receptor blocking agent without intrinsic stimulating activity, on blood pressure, pulse and plasma concentration 2 and 24 h after dose intake and on working capacity and perceived exertion 2 h after dose intake was investigated when given as 100 mg and 200 mg conventional tablets or 200 mg slow-release tablets (Durules) once daily, long-term, to 20 patients with primary (essential) hypertension." | 5.05 | Metoprolol administered once daily in the treatment of hypertension. A double-blind crossover comparison between conventional tablets and metoprolol Durules. ( Asplund, J; Ohman, P, 1981) |
| "In a double-blind study comprising 31 patients with essential hypertension not satisfactorily controlled on hydrochlorothiazide 25 mg o." | 5.05 | Comparative study of hydrochlorothiazide and a fixed combination of metoprolol and hydrochlorothiazide essential hypertension. ( Dafgärd, T; Forsén, B; Lindahl, T, 1981) |
| " 55 patients with essential hypertension grade WHO I and II were randomly allocated to a fixed combination of metoprolol 100 mg and hydrochlorothiazide 12." | 5.05 | Antihypertensive effect and tolerability of two fixed combination of metoprolol and hydrochlorothiazide followed by a long-term tolerance study with one combination. ( Liedholm, H; Ursing, D, 1981) |
| "Seventy-one patients with mild-to-moderate essential hypertension completed 14 weeks' treatment with a single daily dose of fixed combination of metoprolol tartrate 100 mg and chlorthalidone 25 mg (Logroton; Geigy)." | 5.05 | A fixed combination of metoprolol and chlorthalidone in hypertension. A clinical trial in general practice. ( Govind, U; Munro, BF; Robertson, LI, 1981) |
| "The antihypertensive effect of slow-release metoprolol was studied in 50 patients suffering from mild to moderate essential hypertension." | 5.05 | A double-blind crossover comparative study of the efficacy of single daily doses of conventional and slow-release metoprolol. ( Harvard, CW; Nievel, JG, 1981) |
| "The antihypertensive effects of hydrochlorothiazide and spironolactone when added to treatment with metoprolol were compared in a double-blind trial comprising 55 previously untreated patients with essential hypertension." | 5.05 | A double-blind comparison of spironolactone and hydrochlorothiazide in hypertensive patients treated with metoprolol. ( Hansson, L; Lavenius, B, 1982) |
| "The effects of metropolol (beta 1-selective), propranolol (nonselective) and clonidine (central alpha-stimulant) on plasma norepinephrine, blood pressure and heart rate were assessed at rest, during isometric work and dynamic exercise in 15 patients with moderate hypertension." | 5.05 | Response of blood pressure and plasma norepinephrine to propranolol, metoprolol and clonidine during isometric and dynamic exercise in hypertensive patients. ( Frick, MH; Jänne, J; Virtanen, K, 1982) |
| "The clinical effects, the exercise test answer, the left ventricular function by polygraphyc test after administration at middle term of Metoprolol and Labetalol have been evaluated in 20 patients with moderate and non complicated essential hypertension." | 5.05 | [Clinical, ergometric and polygraphic evaluation of the effects of metoprolol and labetalol administration in essential arterial hypertension. Comparative study]. ( Attisano, N; Grenci, G; Martelli, G; Sarica, G; Schirripa, V, 1982) |
| "In a double-blind trial 26 patients with essential hypertension were treated with nifedipine or placebo for 8 weeks, following a 4-week run-in-placebo period in all patients." | 5.05 | Effects of treatment with nifedipine and metoprolol in essential hypertension. ( Eggertsen, R; Hansson, L, 1982) |
| "1 In a double-blind study, 36 patients with essential hypertension were randomly allocated to treatment with either metoprolol, 100--300 mg/day, or pindolol, 5--15 mg/day for 6 months." | 5.05 | Haemodynamic effects of metoprolol and pindolol: a comparison in hypertensive patients. ( Gudbrandsson, T; Hansson, L; Sivertsson, R; Svensson, A, 1982) |
| " Thirty-six patients with essential hypertension, were randomly allocated to double-blind treatment with either metoprolol (100--200 mg/day) or pindolol (5--10 mg/day)." | 5.05 | Metoprolol and pindolol in hypertension: different effects on peripheral haemodynamics. ( Gudbrandsson, T; Hansson, L; Sivertsson, R; Svensson, A, 1981) |
| "1 In an open, randomized cross-over investigation of thirteen patients (nine and four women, aged 37-67 years) with mild or moderate essential hypertension a comparison between atenolol and metoprolol was carried out in order to study the effects of 50, 100 and 200 mg given once daily on blood pressure and heart rate at rest and during exercise." | 5.05 | A comparative study of atenolol and metoprolol in the treatment of hypertension. ( Arnung, K; Eskildsen, PC; Nielsen, PE; Rasmussen, S, 1981) |
| "28 patients, aged 35-62 years, with uncomplicated hypertension, entered a double-blind, crossover study, in which the effects of single daily doses of sotalol and metoprolol were compared." | 5.05 | Sotalol and metoprolol comparison of their anti-hypertensive effect. ( Andersson, O; Berglund, G; Descamps, R; Thomis, J, 1981) |
| "The efficacy of metoprolol as an antihypertensive agent was assessed in 20 previously untreated Asian patients with mild to moderate hypertension." | 5.05 | A comparison between once-daily and twice-daily administration of metoprolol in the management of hypertension. ( Chia, BL, 1980) |
| "In 10 patients with primary arterial hypertension of mild or moderate degree, ketanserin, a competitive antagonist of serotonin receptors, was given for a period of 4 weeks, 40 mg twice daily." | 5.05 | Study with the competitive 5-HT2-serotonergic antagonist ketanserin. ( Fasano, ML; Ferrara, LA; Mancini, M; Marotta, G; Rubba, P; Soro, S, 1985) |
| "Weight reduction was compared with metoprolol (200 mg daily) in a randomised placebo-controlled trial of first-line treatment of mild hypertension (diastolic blood pressure 90-109 mm Hg) in 56 overweight patients aged under 55 years." | 5.05 | Comparison of weight reduction with metoprolol in treatment of hypertension in young overweight patients. ( Andrews, G; Bernstein, L; Blacket, RB; Macdonald, GJ; MacMahon, SW, 1985) |
| "Ketanserin, an investigational, antiserotonergic agent, at a dose of 40 mg bid was given to 18 patients with mild to moderate primary hypertension in a randomized, double-blind, crossover study, with 100-mg metoprolol bid for four weeks each." | 5.05 | Cardiovascular effects of ketanserin, a new antiserotonergic agent in the treatment of arterial hypertension. ( Fasano, ML; Ferrara, LA; Iannuzzi, A; Rubba, P; Soro, S, 1985) |
| "Thirty-one patients aged 65 y or over suffering from moderate hypertension were studied for 16 weeks using a cross-over design in which metoprolol 100 mg daily and metoprolol 200 mg daily were compared." | 5.05 | Metoprolol in the aged hypertensive: a comparison of two dosage schedules. ( Browning, RC; Martin, A, 1985) |
| "In an open, controlled trial, treatment with a combination of metoprolol and hydralazine was compared with non-pharmacological management of mild and moderate hypertension in pregnancy." | 5.05 | A prospective controlled trial of metoprolol-hydralazine treatment in hypertension during pregnancy. ( Axelsson, O; Högstedt, S; Lindberg, BS; Lindeberg, S; Lindmark, G; Rane, A; Sandström, B, 1985) |
| "Effects of long-term treatment with pindolol (10 mg twice daily) and metoprolol (100 mg twice daily) on lung function and blood pressure were investigated in eight patients with chronic obstructive lung disease and hypertension." | 5.05 | Ventilatory effects of long-term treatment with pindolol and metoprolol in hypertensive patients with chronic obstructive lung disease. ( Folgering, HT; Lammers, JW; van Herwaarden, CL, 1985) |
| " placebo was carried out in a series of twenty-three patients with mild or moderate essential hypertension who were receiving chlorthalidone (25 mg daily) as their basic treatment." | 5.04 | A controlled study on the antihypertensive effect of a new beta-adrenergic receptor blocking drug, metoprolol, in combination with chlorthalidone. ( Jäättelä, A; Pyörälä, K, 1976) |
| "The effect of metoprolol, a new beta1-adrenoceptor blocking agent, was compared to practolol in the treatment of hypertension in seventeen asthmatics during concurrent optimum bronchodilator therapy with a selective beta2-adrenoceptor-stimulant." | 5.04 | The effect of metoprolol and practolol on lung function and blood pressure in hypertensive asthmatics. ( Formgren, H, 1976) |
| "The antihypertensive effects on metoprolol and pindolol were compared in 50 patients with essential hypertension belonging to WHO stage 1 or 2." | 5.04 | A comparison between metoprolol and pindolol in the treatment of essential hypertension. ( Pohjola, M; Tuomilehto, J, 1978) |
| " and an oral glucose load, respectively, in nine males with moderate hypertension before treatment, after one month on placebo and after three months on the cardioselective beta-receptor blocking agent metoprolol." | 5.04 | Glucose tolerance and insulin release in hypertensive patients treated with the cardioselective beta-receptor blocking agent metoprolol. ( Ekberg, G; Hansson, BG, 1977) |
| "Ninety-nine patients took part in a multicentre, long-term study of metoprolol in the treatment of hypertension." | 5.04 | Results from a multicentre trial of metoprolol and a study of hypertensive patients with chronic obstructive lung disease. ( Assaykeen, TA; Hua, AS; Kincaid-Smith, PS; Nyberg, G, 1978) |
| " The antihypertensive effects of alpha-methyldopa and metoprolol have been compared in 110 patients (fifty-one males and fifty-nine females) with previously untreated essential hypertension (sixty-eight WHO stage 1 and forty-two WHO stage 2)." | 5.04 | Antihypertensive activity of alpha-methyldopa on a twice daily regimen in comparison to metoprolol. A multi-centre controlled clinical trial. ( Agabiti-Rosei, E; Alicandri, C; Motolese, M; Muiesan, G, 1978) |
| "After a control period on a placebo, 45 patients with mild to moderate hypertension were treated with metoprolol, 100 mg twice daily alone and in free combination with chlorthalidone 50 mg daily using a double-blind crossover technique." | 5.04 | Metoprolol with and without chlorthalidone in hypertension. ( Ebbutt, A; John, V; Kendall, M; Kubik, M, 1979) |
| "The antihypertensive effect of the selective beta-1-adrenoceptor blocker, metoprolol, administered once daily was evaluated in 32 patients with primary hypertension." | 5.04 | Once-daily metoprolol in primary hypertension. ( Karlberg, BE; Nilsson, O; Nitelius, E; Tolagen, K; Waern, U, 1979) |
| " The adequacy of the control of essential hypertension during exercise was studied in patients whose resting blood pressure had been controlled for 1 year with either metoprolol or methyldopa." | 5.04 | Effect of exercise in hypertension controlled with metoprolol or methyldopa. ( Barbour, MP; Hillis, WS; Lawrie, TD; Linden, RJ; Lorimer, AR; Sreeharan, N; Stoker, JB, 1979) |
| " The effect of a single dose of propranolol and metoprolol were compared with placebo in two groups of patients with untreated essential hypertension." | 5.04 | Objective measurement of performance during acute stress in patients with essential hypertension: assessment of the effects of propranolol and metoprolol. ( Dunn, FG; Lawrie, TD; Lorimer, AR, 1979) |
| "The effects of single doses of propranolol and metoprolol on skin temperature and skin and muscle blood flow were compared in 10 normal subjects and four patients with essential hypertension." | 5.04 | Effects of propranolol and metoprolol on the peripheral circulation. ( McSorley, PD; Warren, DJ, 1978) |
| "In 19 patients with arterial hypertension the hemodynamics were determined with a Swan-Ganz-thermodilution catheter at rest and during supine ergometer exercise before and after 5 mg intravenous Propranolol (P) (10 pats." | 5.04 | [Hemodynamic changes in patients with arterial hypertension after beta-receptor blockade with propranolol and metoprolol (author's transl)]. ( Greding, H; Isbary, J; König, E; Nechwatal, W, 1978) |
| "A crossover comparison of metoprolol and hydrochlorothiazide has been performed in 20 patients with mild hypertension." | 5.04 | Comparison of metoprolol as hydrochlorothiazide and antihypertensive agents. ( Pedersen, OL, 1976) |
| "The hypotensive actions of metoprolol and alpha-methyldopa have been compared in 37 men with previously untreated essential hypertension; 36 belonged to stage 1 and 1 to stage 2 of the WHO classification." | 5.04 | Comparative study of metoprolol and alpha-methyldopa in untreated essential hypertension. ( Berglund, G; Bergstrand, RH; Vedin, JA; Wilhelmsson, CE, 1976) |
| " A double-blind cross-over evaluation of the anti-hypertensive effect of metoprolol vs placebo was carried out in a series of twenty-three patients with mild or moderate essential hypertension who were receiving 25 mg of chlorthalidone daily as their basic treatment." | 5.04 | A controlled study on the anti-hypertensive effect of a new beta-adrenoreceptor-blocking drug, metoprolol, in combination with chlorthalidone. ( Jäättelä, A; Pyörälä, K, 1976) |
| "A MEDLINE literature search (1966-May 2013) was performed using the following key terms: hypertension, β-blockers, atenolol, carvedilol, metoprolol tartrate, metoprolol succinate, nebivolol, pharmacology, pharmacodynamics, pharmacokinetics, blood pressure, metabolic, lipid, central aortic pressure, diabetes, and insulin resistance." | 4.90 | β-blockers: a review of their pharmacological and physiological diversity in hypertension. ( Ripley, TL; Saseen, JJ, 2014) |
| "A clinically significant interaction between epinephrine or levonordefrin with nonselective beta-adrenergic blocking agents, although apparently rare in the dental setting, is potentially serious and can lead to significant hypertension with a concomitant reflex bradycardia." | 4.86 | Beta-adrenergic blocking agents and dental vasoconstrictors. ( Giannakopoulos, H; Hersh, EV, 2010) |
| "Review oral modified release drug forms of beta-adrenoblocker metoprolol which is used in arterial hypertension and ischemic heart disease is presented." | 4.86 | [Evolution of oral drug forms of metoprolol: advantages of long acting modified release forms with modified release]. ( Belousov, IuB; Leonova, MV; Maneshina, OA, 2010) |
| "In the review the basic studies devoted to researching of effectiveness of metoprolol in treatment of essential hypertension and also influence of this drug in the prognosis in this group of patients, are summarized." | 4.82 | [Metoprolol in the treatment of essential hypertension]. ( Minushkina, LO; Sidorenko, BA, 2003) |
| "Conventional formulations of metoprolol have become well established in cardiovascular medicine and are particularly useful in the management of hypertension and ischaemic heart disease." | 4.78 | Controlled release metoprolol formulations. A review of their pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension and ischaemic heart disease. ( Clissold, SP; Plosker, GL, 1992) |
| "Metoprolol is a relatively beta 1-selective beta-blocker used extensively to treat hypertension and angina and as a prophylaxis after myocardial infarction." | 4.78 | Controlled release metoprolol. Clinical pharmacokinetic and therapeutic implications. ( Kendall, MJ; Maxwell, SR; Sandberg, A; Westergren, G, 1991) |
| "Multiclinic controlled studies have shown that enalapril alone 10 to 40 mg/day orally is effective in lowering blood pressure in patients with essential hypertension." | 4.77 | Enalapril in hypertension and congestive heart failure. Overall review of efficacy and safety. ( Davies, RO; Moncloa, F; Sromovsky, JA; Walker, JF, 1985) |
| "During the intervening years since metoprolol was first reviewed in the Journal (1977), it has become widely used in the treatment of mild to moderate hypertension and angina pectoris." | 4.77 | Metoprolol. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in hypertension, ischaemic heart disease and related cardiovascular disorders. ( Benfield, P; Brogden, RN; Clissold, SP, 1986) |
| "To observe the effect of amlodipine besylate combined with metoprolol in treating hypertension and heart failure." | 4.31 | Improvement in hemodynamics of amlodipine besylate combined with metoprolol in patients with hypertension complicated by heart failure. ( Chen, C; Jiao, D; Shen, J; Zhang, W; Zhang, X; Zhu, G, 2023) |
| "We collected clinical data on attributes related to hypertension and its therapy of inpatients from West China Hospital who received metoprolol therapy and constructed the sensitive spectrum using data-visualisation tools." | 4.02 | Identifying drug-related attributes to personalise antihypertensive agents: the outcome report of patients receiving metoprolol therapy. ( Liu, C; Liu, R; Su, L; Wang, M; Xu, J; Yan, H; Zhang, Q; Zhuo, Y, 2021) |
| "001), a sub-analysis on those with hypertension diagnosis confirmed that only the hypertensive population taking atenolol had a significantly larger population of obese individuals (BMI ≥25) compared with those who took metoprolol (58." | 3.96 | Association between beta-blocker use and obesity in Hong Kong Chinese elders: a post-hoc analysis. ( Bajorek, B; Fong, W; Freedman, B; Lee, VWY; Leung, KL, 2020) |
| "Metoprolol succinate is a long-acting beta-blocker prescribed for the management of hypertension (HTN) and other cardiovascular diseases." | 3.96 | Metabolomic profiling of metoprolol hypertension treatment reveals altered gut microbiota-derived urinary metabolites. ( Brocker, CN; Flaten, HK; Gonzalez, FJ; Krausz, KW; McDaniel, K; McWilliams, G; Monte, AA; Saben, J; Shelton, SK; Velenosi, T, 2020) |
| "Methyldopa and amlodipine are associated with the least side effects in pregnant women treated for chronic hypertension." | 3.96 | The comparison of side effects of methyldopa, amlodipine, and metoprolol in pregnant women with chronic hypertension. ( Ghafarzadeh, M; Namdari, P; Shakarami, A; Yari, F, 2020) |
| "The β1‑adrenergic receptor (AR) is the primary β‑AR subtype in the heart and is the target of metoprolol (Met), which is commonly used to treat angina and hypertension." | 3.85 | Downregulation of the β1 adrenergic receptor in the myocardium results in insensitivity to metoprolol and reduces blood pressure in spontaneously hypertensive rats. ( Huang, LH; Huang, Y; Li, Y; Liu, X; Liu, XL; Lu, Y; Miao, RJ; Wen, J; Xing, XW; Yuan, H, 2017) |
| "Our findings suggest that neonates born to mothers exposed to β blockers in late pregnancy, including labetalol, are at elevated risk for neonatal hypoglycemia and bradycardia." | 3.83 | Late Pregnancy β Blocker Exposure and Risks of Neonatal Hypoglycemia and Bradycardia. ( Bateman, BT; Desai, RJ; Fischer, MA; Hernandez-Diaz, S; Huybrechts, KF; Maeda, A; Mogun, H; Patorno, E; Seely, EW, 2016) |
| "Chinese patients with essential hypertension were treated with the β-blocker metoprolol and followed up for 12 weeks." | 3.81 | Associations between ADRB1 and CYP2D6 gene polymorphisms and the response to β-blocker therapy in hypertension. ( Deng, M; Guo, X; Huang, X; Li, G; Song, W; Wu, D; Wu, S; Wu, Z; Xu, J, 2015) |
| " The curative effect of metoprolol tartrate and valsartan in reversing left ventricular hypertrophy in the group positive for autoantibodies was much better than in the negative group." | 3.80 | Autoantibodies against β1 receptor and AT1 receptor in type 2 diabetes patients with left ventricular dilatation. ( Xu, C; Xu, J; Zhao, L, 2014) |
| " The diabetic and control non-diabetic rats were assigned randomly to receive no anti-hypertension treatment, or to be treated with the angiotensin II receptor blocker (ARB), valsartan (40 mg/kg/d) or the beta-blocker, metoprolol (50 mg/kg/day)." | 3.78 | Aquaporin changes during diabetic retinopathy in rats are accelerated by systemic hypertension and are linked to the renin-angiotensin system. ( Fan, J; Hoffman, MR; Qin, Y; Ren, H; Xu, G; Zhang, M, 2012) |
| " We have learned that she was prescribed metoprolol at another medical center to treat new onset hypertension." | 3.78 | Palmar psoriasis, a rare side effect of beta-blocker theraphy: a case report. ( Demirkan, B; Güray, U; Güray, Y; Refiker Ege, M, 2012) |
| " Two days before hospitalization, he developed cough and sputum and he visited an outpatient clinic, where dextromethorphan was prescribed." | 3.77 | Myoclonus after dextromethorphan administration in peritoneal dialysis. ( Fujita, Y; Ito, Y; Maeda, K; Nagamatsu, T; Nagura, F; Nomura, A; Shimizu, H; Tanaka, A; Tomino, T; Watanabe, T; Yamaguchi, M, 2011) |
| " In this study, we characterised left ventricular thrombospondin-1 and -4 expression in rats treated with a beta-blocker metoprolol during the remodelling process in response to pressure overload and acute myocardial infarction." | 3.76 | Metoprolol treatment lowers thrombospondin-4 expression in rats with myocardial infarction and left ventricular hypertrophy. ( Aro, J; Leskinen, H; Luodonpää, M; Mustonen, E; Ruskoaho, H; Rysä, J; Vuolteenaho, O, 2010) |
| "Obvious elevation of PP is associated with a better response to metoprolol succinate sustained-release tablets in elderly hypertensive patients with chronic heart failure, and 3 months of treatment with the tablets can significantly improve the cardiac function and lower the levels of VEGF, hs-CRP and BNP in these patients." | 3.76 | [Response to metoprolol succinate sustained-release tablets in correlation to pulse pressure, serum vascular endothelial growth factor and C-reactive protein in elderly hypertensive patients with chronic heart failure]. ( Lin, ZP; Zhang, ZW, 2010) |
| "The aim of this work was to study effects of metoprolol on structural and functional characteristics of left ventricle (LV), cerebral circulation (CC), microcirculation (MC), lipid spectrum, rheologic and viscous properties of blood in patients with grade II-III hypertensive disease (HD) and metabolic syndrome." | 3.76 | [Hypertensive disease and metabolic syndrome: application of metoprolol]. ( Koren'kov, VV; Markova, EV; Markova, LI; Radzevich, AE; Samoĭlenko, TN; Sokolova, NV, 2010) |
| " The aim of the present study was to investigate the prevalence of hypertension in patients with dilated cardiomyopathy (DCM) and to determine the tolerance and efficacy of a high dose of the β1-adrenoceptor antagonist metoprolol in the long-term treatment of DCM patients." | 3.75 | Dilated cardiomyopathy with hypertension: prevalence and response to high-dose β1-adrenoceptor antagonist therapy. ( Chen, S; Chen, Y; Wang, J; Yang, T; Zheng, X, 2009) |
| " We describe a case of cardiogenic shock following the administration of metoprolol to treat hypertension, (likely) induced by systemic absorption of topical epinephrine used during a routine nasal septoplasty." | 3.74 | Cardiogenic shock following nasal septoplasty: a case report and review of the literature. ( Hamstra, J; Mulji, A; Schwalm, JD; Velianou, JL, 2008) |
| "The objective of this study was to compare cardiovascular and renal events in patients with hypertension receiving the angiotensin II-receptor blocker valsartan versus those receiving the angiotensin-converting-enzyme lisinopril or the beta-blocker metoprolol succinate in an extended-release formulation." | 3.74 | Valsartan versus lisinopril or extended-release metoprolol in preventing cardiovascular and renal events in patients with hypertension. ( Delea, TE; Frech-Tamas, F; Moynahan, A; Oster, G; Taneja, C; Thomas, SK, 2007) |
| "To assess efficacy and safety of selective beta-adrenoblockers (BAB) metoprolol succinate and nebivolol in patients with arterial hypertension (AH) and/or IHD associated with bronchoobstructive syndrome (BOS)." | 3.74 | [Administration of cardioselective beta-adrenoblockers in patients with arterial hypertension and/or ischemic heart disease associated with bronchoobstructive syndrome]. ( Litvinova, IV; Mikolkin, VI; Ovcharenko, SI, 2007) |
| " Nondiabetics with hypertension (N=30) were started on (or changed to) hydrochlorothiazide (HCTZ) 12." | 3.73 | Metoprolol succinate, a selective beta-adrenergic blocker, has no effect on insulin sensitivity. ( Falkner, B; Francos, G; Kushner, H, 2006) |
| "Chronic treatment with cyclosporine A (CsA), a potent immunosuppressive agent, is associated with the development of arterial hypertension." | 3.72 | Role of metoprolol, B1-adrenoceptor antagonist, thromboxane A2 and nitric oxide in CsA-induced hypertension. ( Oriji, GK, 2003) |
| " We tested the hypothesis that 2 common polymorphisms in the gene for beta(1)-adrenergic receptor are associated with antihypertensive response to metoprolol in patients with uncomplicated hypertension." | 3.72 | Beta 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol. ( Johnson, JA; McGorray, SP; Pauly, DF; Puckett, BJ; Yarandi, HN; Zineh, I, 2003) |
| "To compare efficacy and safety of cardioselective beta-adrenoblockers nebivolol and metoprolol in patients with hypertension and ischemic heart disease (IHD) combined with type 2 diabetes." | 3.72 | [Clinical and metabolic effects of cardioselective beta-adrenoblockers nebivolol and metoprolol in patients with hypertension and ischemic heart disease associated with type 2 diabetes]. ( Akhmedova, OO; Buval'tsev, VI; Gavrilov, IuV; Makolkin, VI; Petriĭ, VV, 2003) |
| "Centrally acting (moxonidine) and peripherally acting (metoprolol) sympatholytic agents might have different actions upon penile circulation in hypertensive men with erectile dysfunction." | 3.72 | Effects of moxonidine and metoprolol in penile circulation in hypertensive men with erectile dysfunction: results of a pilot study. ( Kaaja, R; Piha, J, 2003) |
| "The Metoprolol CR/XL Randomized Intervention Trial in Chronic Heart Failure (MERIT-HF), the Cardiac Insufficiency Bisoprolol Study II (CIBIS-II), and the Carvedilol Prospective Randomized Cumulative Survival Study (COPERNICUS) have all demonstrated highly significant positive effects on total mortality as well as total mortality plus all-cause hospitalization in patients with heart failure." | 3.72 | How should subgroup analyses affect clinical practice? Insights from the Metoprolol Succinate Controlled-Release/Extended-Release Randomized Intervention Trial in Heart Failure (MERIT-HF). ( Deedwania, P; Fagerberg, B; Ghali, J; Goldstein, S; Gottlieb, S; Hjalmarson, A; Kjekshus, J; Waagstein, F; Wedel, H; Wikstrand, J, 2003) |
| "Bupropion is an increasingly prescribed agent to aid in smoking cessation." | 3.72 | Severe sinus bradycardia after initiation of bupropion therapy: a probable drug-drug interaction with metoprolol. ( Greene, JL; McCollum, DL; McGuire, DK, 2004) |
| " Postoperatively, the patient had persistent sinus tachycardia that was initially unsuccessfully treated with metoprolol." | 3.70 | Treatment of milrinone-associated tachycardia with beta-blockers. ( Alhashemi, JA; Hooper, J, 1998) |
| "An increase in blood pressure, accompanied by atrial fibrillation, agitation, incomprehensible shouts and loss of consciousness, was observed in an elderly, ASA classification group II, cardiovascularly medicated male, 12 min after performance of axillary block with mepivacaine 850 mg containing adrenaline 0." | 3.70 | An unusual toxic reaction to axillary block by mepivacaine with adrenaline. ( Koscielniak-Nielsen, ZJ, 1998) |
| "We present results from a Swedish retrospective cost-effectiveness analysis of felodipine-metoprolol (Logimax) and enalapril in hypertension." | 3.70 | Cost-effectiveness of felodipine-metoprolol (Logimax) and enalapril in the treatment of hypertension. ( Andersson, F; Andersson, OK; Kartman, B, 1998) |
| " The patient was treated with the cardioselective beta-blocking agent, metoprolol, initially for elevated blood pressure and tachycardia at 25 mg twice daily for approximately 2 months." | 3.69 | Metoprolol for action tremor following intracerebral hemorrhage. ( Dove, CA; Escobar, N; Vezzetti, D, 1994) |
| "In 759 patients with acute myocardial infarction in whom serum activity of heat stable lactate dehydrogenase had been determined every 12 hours for 108 hours after randomisation in an early intervention trial with metoprolol." | 3.69 | Ten year mortality in relation to original size of myocardial infarct: results from the Gothenburg metoprolol study. ( Herlitz, J; Hjalmarson, A; Karlson, BW, 1994) |
| "Eighteen previously untreated primary hypertension patients were selected for therapy either with 50-250 mg/day metoprolol (n = 11) or with 3-20 mg/day prazosin (n = 8)." | 3.69 | Differences between the effects of metoprolol and prazosin on the forearm vasculature in primary hypertension. ( Gretzer, I; Hjemdahl, P, 1997) |
| " This article describes the case of a patient affected by pheochromocytoma in whom multiple organ failure developed after contemporary administration of ergotamine, caffeine, and nimesulide." | 3.69 | Pheochromocytoma crisis caused by contemporary ergotamine, caffeine, and nimesulide administration. ( Bartoli, P; Bonechi, F; Brandinelli, A; Del Rosso, A; Fradella, G; Ieri, A; Maioli, M; Mannelli, M; Mazza, F; Russo, L; Sansoni, M; Zipoli, A, 1997) |
| "The aim of the present analysis was to calculate the cost-effectiveness of metoprolol versus thiazide diuretics in middle-aged men with mild to moderate uncomplicated hypertension." | 3.68 | Cost-effectiveness of antihypertensive treatment: metoprolol versus thiazide diuretics. ( Berglund, G; Johannesson, M; Jönsson, B; Tuomilehto, J; Wikstrand, J, 1993) |
| "We compared the antihypertensive effects of acebutolol and metoprolol during 2-4 weeks of treatment in patients with mild to moderate essential hypertension." | 3.68 | [The effect of acebutolol and metoprolol on noninvasive ambulatory blood pressure monitoring system in essential hypertension]. ( Hayashi, T; Ichinohe, T; Ikeda, S; Ikeda, Y; Kawaguchi, K; Kotake, C; Koya, Y; Onaka, H; Seo, T; Suyama, K, 1992) |
| " Despite concern about the use of a beta-blocker in a patient with asthma, pre-operative tachycardia was successfully treated with the beta-1-selective adrenoreceptor antagonist, metoprolol." | 3.68 | Use of beta-blockade in a patient with phaeochromocytoma and asthma. ( Bevan, EG; McInnes, GT, 1992) |
| "Various aspects of carbohydrate and lipid metabolism have been studied in two groups of patients with mild hypertension before and after six months of treatment with either nicardipine (n = 10) or metoprolol (n = 10)." | 3.68 | Comparison of the effects of nicardipine and metoprolol on lipid and glycidic metabolism in hypertensive subjects. ( Andriani, A; Bonfantino, MV; De Cesaris, R; Dentamaro, M; Filitti, V; Ranieri, G, 1991) |
| "Using ultrasound techniques, parameters of left ventricular systolic and diastolic function were assessed in 23 patients with degree I-II essential hypertension treated with metoprolol." | 3.68 | The effect of metoprolol on left ventricular systolic and diastolic function in essential hypertension. ( Hradec, J; Král, J; Petrásek, J, 1991) |
| "The cardiovascular responses of 24 healthy young adult males with a parental history of hypertension and 24 males without a parental history of hypertension to an extended active-coping psychological stressor were compared under three drug conditions: placebo, the beta 1-blocking agent metoprolol, and the alpha 1-blocking agent prazosin." | 3.68 | Exaggerated sympathetic nervous system response to extended psychological stress in offspring of hypertensives. ( Ditto, B; Miller, SB, 1991) |
| "In 30 hypertensives with angina pectoris the acute action of beta-blockers Celiprolol and Metoprolol on the global and coronary haemodynamics was tested within cardiac catheter diagnostics." | 3.68 | [Acute changes of coronary and global hemodynamics in patients with angina pectoris and arterial hypertension caused by celiprolol and metoprolol]. ( Bruch, L; Franz, N; Gola, G; Heublein, B; Linss, G; Modersohn, D; Walde, T, 1990) |
| "We compared the effects of the angiotensin-converting enzyme inhibitor enalapril and a conventional antihypertensive regimen (hydralazine and metoprolol) on kidney function, albuminuria, and glomerular ultrastructure in hypertensive diabetic and nondiabetic rats." | 3.68 | Nephropathy in model combining genetic hypertension with experimental diabetes. Enalapril versus hydralazine and metoprolol therapy. ( Allen, TJ; Clarke, BE; Cooper, ME; Doyle, AE; Jerums, G; O'Brien, RC; Papazoglou, D, 1990) |
| "One hundred twenty-six patients with mild to moderate hypertension responsive to beta-adrenergic blocking agents--alone or in combination with other antihypertensive drugs--entered this open-label, multicenter study designed to evaluate the safety and tolerability of metoprolol OROS (metoprolol fumarate)." | 3.68 | Safety and tolerability of metoprolol OROS in hypertension treatment. ( Feliciano, N; Goldstein, RJ; Grau, KE; Hogan, LB; Kasarjian, PH; Kessler, C; McMillen, JI; Montoro, R; Mroczek, WJ; Stevelman, HB, 1990) |
| "The authors tested in an open, uncontrolled trial in a group of 23 patients with essential hypertension grade I-II (WHO classification) the effect of Metoprolol OROS." | 3.68 | [The effect of OROS metoprolol in mild and moderately severe essential hypertension]. ( Hradec, J; Král, J; Petrásek, J, 1990) |
| " We assessed both the renal and the systemic haemodynamic responses to antihypertensive monotherapy (five to seven weeks) with the angiotensin converting enzyme (ACE) inhibitor enalapril (n = 12), in contrast to the cardioselective beta-adrenergic blocker metoprolol (n = 11) in subjects with essential hypertension." | 3.67 | Contrasting renal haemodynamic responses to the angiotensin converting enzyme inhibitor enalapril and the beta-adrenergic antagonist metoprolol in essential hypertension. ( Bernstein, KN; Cervenka, J; Mosley, CA; O'Connor, DT, 1984) |
| "A new experimental model is presented for determining the optimum dose of 3 different doses (13 mg, 25 mg, 37 mg per day) of hydrochlorothiazide employed to enhance hypotensive effect of 200 mg/day of metoprolol in human hypertension." | 3.67 | Assessment of optimal dose of diuretic associated with fixed dose of beta-blocking: a new experimental model based on multiple sampling of blood pressure performed by self-measurements. ( Bigioli, F; Corti, C; Croppi, E; Imperiale, P; Livi, R; Romano, S; Scarpelli, L; Scarpelli, PT; Stinchetti, A, 1984) |
| "Treatment of fifteen patients with essential hypertension over four weeks using the beta 1-adrenoceptor blocking agent, metoprolol, resulted in a decrease in 24 h urinary excretion of kallikrein and aldosterone along with a decrease in plasma renin activity." | 3.67 | Effect of metoprolol on 24-hour urinary excretion of adrenal steroids and kallikrein in patients with essential hypertension. ( Fritschka, E; Gotzen, R; Kittler, R; Schöneshöfer, M, 1984) |
| "Thirty patients with essential hypertension, whose blood pressure was controlled by metoprolol, were divided according to age in two groups." | 3.67 | [Effects of delayed-action metoprolol evaluated in hypertensive patients responsive to therapy subdivided in 2 different age groups]. ( Carpentiere, G; Castello, A; Castello, F; Cellura, M; Marino, S, 1984) |
| "Paradoxical glucose-induced serum potassium elevation was found exclusively in the upright position in 9 patients with essential hypertension treated with metoprolol." | 3.67 | Glucose induced paradoxical serum potassium elevation exclusively in the upright posture in metoprolol treated hypertensives. ( Radó, JP, 1984) |
| "The effects of chlorthalidone and metoprolol on fasting plasma lipids and lipoprotein levels were compared in two similar nonrandomized groups of patients with mild hypertension." | 3.67 | Different effects of metoprolol and chlorthalidone on serum lipoprotein levels in mild hypertension. Possible implications for coronary heart disease risk status. ( Goldbourt, U; Holtzman, E; Rosenthal, T; Segal, P, 1984) |
| "The transfer of atenolol and metoprolol to human breast milk was studied in 7 lactating women with hypertension." | 3.67 | Atenolol and metoprolol. A comparison of their excretion into human breast milk. ( Kulas, J; Lunell, NO; Rane, A; Rosing, U; Stéen, B, 1984) |
| " The effects of chlorthalidone and metoprolol on fasting plasma lipids and lipoprotein levels were compared in two similar nonrandomized groups of patients with mild hypertension." | 3.67 | Do beta-blockers alter lipids and what are the consequences? ( Goldbourt, U; Holtzman, E; Rosenthal, T; Segal, P, 1987) |
| "An identical antihypertensive regimen with Metoprolol, a beta-blocking agent, was compared in two groups of patients with mild to moderate hypertension regarding effectiveness and side effects." | 3.67 | [The treatment of essential hypertension in the hospital and in the office: is there a difference?]. ( Baettig, B; Steiner, A; Vetter, W, 1989) |
| "A study has been performed in thirteen patients with essential hypertension, WHO Class I-II, and a diastolic blood pressure greater than or equal to 95 mmHg, on beta-blocker (metoprolol or atenolol) monotherapy, who were also given felodipine 10 mg b." | 3.67 | Haemodynamic effects and pharmacokinetics of felodipine at rest and during exercise in hypertensive patients treated with metoprolol or atenolol. ( Bengtsson-Hasselgren, B; Elmfeldt, D; Moberg, L; Rönn, O, 1989) |
| "The effects of two-week treatment periods with indenolol (I) and metoprolol (M) were examined by 24-hour mean blood pressure (BP) monitoring in control conditions and during exercise stress test in 7 patients with essential hypertension, using the Oxford method." | 3.67 | Efficacy of a new antihypertensive agent (indenolol) assessed by ambulatory blood pressure monitoring. ( Bonaduce, D; Breglio, R; Canonico, V; Condorelli, M; Cuocolo, A; Groothold, G; Ricciardelli, B; Trimarco, B, 1985) |
| "Six elderly patients with established hypertension and six young healthy subjects were studied after 8 days of treatment with atenolol 50 mg day-1, metoprolol 50 mg day-1, oxprenolol 80 mg day-1 and propranolol 80 mg day-1." | 3.67 | A comparison of the pharmacokinetics of atenolol, metoprolol, oxprenolol and propranolol in elderly hypertensive and young healthy subjects. ( Hawksworth, GM; Petrie, JC; Rigby, JW; Scott, AK, 1985) |
| "The antihypertensive activity of a new arterial dilator, cadralazine, was evaluated in 40 patients with mild-to-moderate arterial hypertension." | 3.67 | Antihypertensive activity of a new vasodilator, cadralazine, administered alone or in combination with a beta-blocker. ( Buoninconti, R; Motolese, M, 1985) |
| "7 years), with previously untreated essential hypertension and echocardiographically proven left-ventricular hypertrophy, received metoprolol 200 mg daily over a period of 12." | 3.67 | [Regression of myocardial hypertrophy in hypertensives on chronic beta-receptor block]. ( Behr, M; Franz, IW; Ketelhut, R; Wiewel, D, 1986) |
| "The influence of beta-adrenergic blockade with metoprolol, a beta 1-selective agent, on the adrenergic regulation of lipid mobilization was explored in subcutaneous adipocytes removed from 13 patients with essential hypertension." | 3.67 | Long-term beta 1-selective adrenergic blockade and adrenergic receptors in human subcutaneous adipocytes. ( Arner, P; Engfeldt, P; Haglund, K; Ostman, J; Rössner, S; Wahrenberg, H, 1985) |
| "The acute haemodynamic effect of metoprolol was investigated in 14 patients with essential hypertension (7 of the WHO stage I, 7 of stage II)." | 3.67 | Acute haemodynamic effect of metoprolol in essential hypertension. ( Mikulecký, M; Pechán, J; Srbecký, M, 1988) |
| "A dose titration study was performed using felodipine, a new calcium antagonist, in Chinese patients with essential hypertension inadequately controlled by metoprolol alone (DBP greater than 95 mmHg)." | 3.67 | The effects of combining felodipine and metoprolol in moderate to severe hypertension--a one year study. ( Chow, J, 1988) |
| "Oral administration of felodipine to 10 patients with mild essential hypertension acutely reduced the brachial artery pressure by 15/13mm Hg." | 3.67 | Effects of felodipine and metoprolol on blood pressure, plasma renin, angiotensin II, aldosterone and catecholamines in hypertensive patients. ( Amery, A; De Schaepdryver, A; Fagard, R; Lijnen, P; Moerman, E; Staessen, J, 1987) |
| "Seven women were treated with metoprolol 50-100 mg twice daily for hypertension in pregnancy." | 3.67 | Disposition of the adrenergic blocker metoprolol and its metabolite OH-metoprolol in maternal plasma, amniotic fluid and capillary blood of the neonate. ( Lindeberg, S; Lundborg, P; Regårdh, CG; Sandström, B, 1987) |
| "Oral administration of felodipine to 10 patients with mild essential hypertension acutely reduced systemic vascular resistance (SVR) by 40% after 30 min." | 3.67 | Acute haemodynamic and humoral responses to felodipine and metoprolol in mild hypertension. ( Amery, A; Fagard, R; Lijnen, P; Moerman, E; Staessen, J, 1987) |
| "The antihypertensive and vasodilator effects of felodipine, a new calcium antagonist of the dihydropyridine group, were examined in 15 patients with moderate to severe hypertension." | 3.67 | Effect of felodipine and metoprolol on muscle and skin arteries in hypertensive patients. ( Clement, DL; De Pue, NY, 1985) |
| "Five women who developed hypertension during pregnancy received metoprolol, 10 mg iv; 3 days later they received metoprolol, 100 mg by mouth." | 3.67 | Pregnancy-induced increase in metoprolol metabolism. ( Högstedt, S; Lindberg, B; Peng, DR; Rane, A; Regårdh, CG, 1985) |
| " Propranolol, acebutolol and practolol, at a daily dose of 50 mg/kg, prevented the occurrence of hypertension, not only during the 4 weeks of treatment, but also during 6,9 and 11 weeks respectively after cessation of treatment." | 3.66 | Variability in the preventive action of the B-blockers on genetic hypertension in the rat. ( Brotelle, R; Colot, M; de Clavière, M; Heyndrickx, JP, 1980) |
| "Twenty-nine patients with severe hypertension (n = 14) or hypertensive crisis (n = 15) were treated with diazoxide infusion and intravenous injection of a beta blocker." | 3.66 | Combined intravenous administration of diazoxide and beta-blocking agent in acute treatment of severe hypertension or hypertensive crisis. ( Huysmans, FT; Koene, RA; Thien, TA, 1982) |
| "The acute effects of Metoprolol on blood pressure and heart rate were studied with reference to the plasma level of the betablocker in 10 patients (6 male and 4 female) with permanent moderate uncomplicated hypertension." | 3.66 | [Acute effects of metoprolol on blood pressure and heart rate. Value of the nitroglycerin test]. ( Aubert, P; Chaignon, M; Guédon, J; Lucsko, M, 1982) |
| "The effects of penbutolol 20-30 mg twice daily and of metoprolol 50-150 mg three times daily were studied in five and nine patients, respectively, with moderate hypertension." | 3.66 | Effects of penbutolol and metoprolol on blood pressure, plasma catecholamines and renin activity in hypertensive patients. ( Dymling, JF; Hansson, BG; Hökfelt, B; Manhem, P, 1983) |
| "The effects of metoprolol, propranolol and hydrochlorothiazide on lipoprotein metabolism were studied in three different but comparable groups of middle-aged men with previously untreated hypertension (n=10, n=10, and n=11, respectively)." | 3.66 | Effects of anti-hypertensive therapy on serum lipoproteins. Treatment with metoprolol, propranolol and hydrochlorothiazide. ( Berglund, G; Bondjers, G; Elmfeldt, D; Fager, G; Lager, I; Olofsson, SO; Smith, U; Wiklund, O, 1983) |
| "The efficacy of metoprolol, a new cardioselective beta-blocking drug, was compared with that of methyldopa in patients with mild to moderate essential hypertension in a long-term study." | 3.66 | A comparative study of metoprolol and methyldopa in the treatment of hypertension. ( Karachalios, GN, 1983) |
| " The effects of 3 wk of treatment with two selective beta 1 blockers, metoprolol and atenolol, were observed in 54 patients with mild or moderate essential hypertension." | 3.66 | Predictability of antihypertensive efficacy of selective beta 1 blockers. ( Condorelli, M; Cuocolo, A; De Luca, N; Ricciardelli, B; Trimarco, B; Veniero, AM; Volpe, M, 1983) |
| "26 patients with moderate hypertension and no signs of heart failure were treated with metoprolol, labetalol or prazosin." | 3.66 | The use of systolic time intervals in the evaluation of antihypertensive treatment with metoprolol, labetalol and prazosin. ( Buch, J; Rasmussen, S, 1983) |
| "A fixed combination of metoprolol slow-release 200 mg and chlorthalidone 25 mg was given once daily over a 3 months period in forty out-patients with mild-to-moderate arterial hypertension stage I or II WHO." | 3.66 | A fixed combination of metoprolol slow-release and chlorthalidone, given once daily, in the long-term treatment of arterial hypertension. ( Bichisao, E; Floris, B; Franchetta, G; Palestini, N; Sonaglioni, G; Verdecchia, P, 1982) |
| "Eleven patients were treated for essential hypertension with metoprolol (Selokén) for more than three months." | 3.66 | Time course of blood pressure, pulse rate, plasma renin and metoprolol during treatment of hypertensive patients. ( Collste, P; Haglund, K, 1980) |
| "10 patients with systemic essential arterial hypertension have been treated with 200 mg/die of Metoprolol." | 3.66 | [The effects of metoprolol on systolic times in patients with systemic arterial hypertension. Polygraphic study]. ( Attisano, N; Grenci, G; Martelli, G; Sarica, G; Schirripa, V, 1982) |
| "The cardioselective betablocking agent metoprolol was used to treat 21 outpatients with essential arterial hypertension graded 1 and 2 of the OMS scale." | 3.66 | [Metoprolol in the treatment of essential hypertension (author's transl)]. ( Beiras García, E; Pérez Pombo, S; Salgueiro Rodríguez, M, 1981) |
| "5 mg hydrochlorothiazide in the treatment of mild to moderate hypertension, with particular reference to elderly patients." | 3.66 | The treatment of high blood pressure in the elderly: a multi-centre evaluation of a fixed combination of metoprolol and hydrochlorothiazide ("Co-Betaloc") in general practice. ( Goodfellow, RM; Westberg, B, 1981) |
| "The antihypertensive effect and the tolerability of metoprolol Durules have been studied in fifty-five patients with mild to moderate hypertension." | 3.66 | Experiences with metoprolol Durules, a slow-release formulation in hypertension. ( Nissinen, A; Tuomilehto, J, 1980) |
| "The effect of the cardioselective beta-adrenoreceptor blocking compound, metoprolol, was compared with methyldopa in the long-term management of hypertension." | 3.66 | Long-term comparison of metoprolol and methyldopa in the treatment of hypertension. ( Barbour, M; Hillis, WS; Lawrie, TD; Leanage, RU; Linden, RJ; Lorimer, AR; Sreeharan, N; Stoker, JB, 1980) |
| " Sixteen patients (11 male, five female), median age 41 years, with essential hypertension insufficiently controlled by hydrochlorothiazide (75 mg/day; diastolic blood pressure greater than or equal to 100 mmHg), were studied." | 3.66 | Angiotensin II blockade during combined thiazide-beta-adrenoreceptor-blocker treatment. ( Giese, J; Ibsen, H; Leth, A; McNair, A, 1979) |
| " Propranolol and metoprolol were given in the diet of spontaneously hypertensive (SH) rats during the development of hypertension." | 3.66 | Protein synthesis and composition of cardiac and vascular tissue in spontaneously hypertensive rats and the effects of beta-adrenergic antagonist treatment. ( Boström, SL; Fryklund, J, 1979) |
| "1 Twelve men with untreated essential hypertension in WHO stage I were studied on an outpatient basis to evaluate the haemodynamic long-term effect of a new beta-adrenoceptor blocker, metoprolol." | 3.65 | Haemodynamic long-term effects of metoprolol at rest and during exercise in essential hypertension. ( Lund-Johansen, P; Ohm, OJ, 1977) |
| "Metoprolol, a cardioselective beta-blocking agent, has been given orally to 12 geriatric patients with moderate hypertension." | 3.65 | Plasma levels and effect on heart rate and blood pressure of metoprolol after acute oral administration in 12 geriatric patients. ( Lundborg, P; Steen, B, 1976) |
| "These studies indicate that the cardioselective beta-adrenergic blocking drug metoprolol might be expected to be at least as effective for the treatment of arterial hypertension as propranolol." | 3.65 | Studies with a new cardioselective beta-blocker, metoprolol. ( Aurell, M; Johnsson, G; Sannerstedt, R; Svedmyr, N; Werkö, L, 1976) |
| " Oral and intravenous administration of metoprolol to adult spontaneously hypertensive rats (SHR) with established hypertension lowered arterial blood pressure within 4 days of treatment." | 3.65 | Anti-hypertensive effect of metoprolol in spontaneously hypertensive rats. ( Ablad, B; Drews, L; Fellenius, E; Kjellstedt, A; Ljung, B; Wallborg, M, 1976) |
| "Atenolol was used in PEAR and INVEST, and metoprolol was used in PEAR-2." | 2.90 | β ( Beitelshees, AL; Boerwinkle, E; Chapman, A; Conrado, DJ; Cooper-DeHoff, RM; Gong, Y; Gonzalez, D; Gums, JG; Johnson, JA; Lobmeyer, MT; Pepine, CJ; Rouby, NE; Shahin, MH; Turner, ST, 2019) |
| "Although orthostatic hypotension (OH) is often considered a contraindication to blood pressure (BP) treatment, evidence is lacking." | 2.87 | Hypertension Treatment Effects on Orthostatic Hypotension and Its Relationship With Cardiovascular Disease. ( Appel, LJ; Juraschek, SP; Lipsitz, LA; Miller, ER; Mukamal, KJ, 2018) |
| " Well-controlled GDM prolonged tmax for both enantiomers of metoprolol (1." | 2.80 | Influence of gestational diabetes on the stereoselective pharmacokinetics and placental distribution of metoprolol and its metabolites in parturients. ( Antunes, Nde J; Cavalli, RC; Lanchote, VL; Marques, MP; Moisés, EC, 2015) |
| "To investigate the effects of ivabradine in combination with perindopril on cerebral blood flow and endothelial functional activity." | 2.77 | [Cerebral blood flow and endothelial functional activity in patients with coronary heart disease and arterial hypertension during therapy with ivabradine in combination with perindopril]. ( Gapon, LI; Kolesnikova, SN; Musikhina, NA; Petelina, TI; Utesheva, AB, 2012) |
| "Arterial hypertension is characterised by increased oxidative stress and inflammation, which are associated with further cardiovascular risk." | 2.77 | Nebivolol and metoprolol: long-term effects on inflammation and oxidative stress in essential hypertension. ( Eha, J; Kals, J; Kampus, P; Kullisaar, T; Serg, M; Zagura, M; Zilmer, K; Zilmer, M, 2012) |
| " Dosage of felodipine were doubled after 4 weeks if the blood pressure were > or = 140/ 90 mm Hg (1 mm Hg = 0." | 2.76 | [Effect of different combined antihypertensive regimen on the erectile function in male hypertensive patients]. ( Bai, F; Chang, P; Guo, XY; Hu, H; Li, XL; Liu, PJ; Ma, RX; Yang, LQ; Yu, J; Zhao, F, 2011) |
| "With carvedilol treatment, LVMI was lower (p<0." | 2.75 | Effect of carvedilol on coronary flow reserve in patients with hypertensive left-ventricular hypertrophy. ( Mei, Z; Xiaozhen, H; Yu, S; Yun, Z, 2010) |
| "In this study, 1235 participants with type 2 diabetes and hypertension who were receiving renin-angiotensin system blockers were randomized either to carvedilol, receiving 6." | 2.74 | Comparison of carvedilol and metoprolol on serum lipid concentration in diabetic hypertensive patients. ( Bakris, GL; Bell, DS; McGill, JB, 2009) |
| "High blood pressure is one of the most important risk factors, directly responsible for increasing the cardiovascular morbidity and mortality." | 2.74 | Antihypertensive efficacy of metoprolol XL/low dose chlorthalidone (6.25 mg) combination: a randomized, comparative study in indian patients with mild-to-moderate essential hypertension. ( Chandurkar, NB; Karnik, ND; Pareek, A; Salagre, SB; Zawar, SD, 2009) |
| "Carvedilol effects were favorable to adjustment of age as a covariate." | 2.73 | Demographic analyses of the effects of carvedilol vs metoprolol on glycemic control and insulin sensitivity in patients with type 2 diabetes and hypertension in the Glycemic Effects in Diabetes Mellitus: Carvedilol-Metoprolol Comparison in Hypertensives ( ( Anderson, KM; Bakris, GL; Bell, DS; Fonseca, V; Iyengar, M; Katholi, RE; Lukas, MA; McGill, JB; Messerli, FH; Phillips, RA; Raskin, P; Wright, JT, 2008) |
| "Insulin resistance was measured by homeostasis assessment index (HOMA)." | 2.73 | Effect of antihypertensive agents on plasma adiponectin levels in hypertensive patients with metabolic syndrome. ( Acikel, C; Caglar, K; Celik, T; Eyileten, T; Oguz, Y; Sonmez, A; Vural, A; Yavuz, I; Yenicesu, M; Yilmaz, MI, 2007) |
| "Sibutramine treatment resulted in a significantly greater decrease in body weight, body mass index, and waist circumference and a significant increase in diastolic blood pressure during 24-hour blood pressure monitoring compared with placebo treatment." | 2.73 | Optimal treatment of obesity-related hypertension: the Hypertension-Obesity-Sibutramine (HOS) study. ( Grimm, E; Herrmann, D; Kintscher, U; Scholze, J; Unger, T, 2007) |
| "Atenolol and metoprolol succinate, dosed once daily, have different pharmacokinetic profiles." | 2.73 | Comparative efficacy of two different beta-blockers on 24-hour blood pressure control. ( Bakris, GL; Basta, E; Bogojevic, Z; Kirstner, E; Sarafidis, P, 2008) |
| " All patients received metoprolol at a dosage titrated to achieve a diastolic blood pressure below 90 mm Hg." | 2.72 | Discordant beta-blocker effects on clinic, ambulatory, resting, and exercise hemodynamics in patients with hypertension. ( Beitelshees, AL; Johnson, JA; Pauly, DF; Yarandi, HN; Zineh, I, 2006) |
| "Subjects with type 2 diabetes experience an increased cardiovascular morbidity and mortality, related to a high prevalence of hypertension, dyslipidemia, and obesity." | 2.71 | Effects of moxonidine vs. metoprolol on blood pressure and metabolic control in hypertensive subjects with type 2 diabetes. ( Gödicke, J; Häring, HU; Helsberg, K; Jacob, S; Klimm, HJ; Rett, K, 2004) |
| "This study was performed to estimate the mean pharmacokinetic parameters of routinely administered metoprolol in middle-aged and elderly Japanese patients." | 2.71 | Nonlinear mixed effects model analysis of the pharmacokinetics of metoprolol in routinely treated Japanese patients. ( Hashimoto, Y; Inoue, H; Mizumaki, K; Nozawa, T; Taguchi, M; Tahara, K; Takesono, C, 2004) |
| "The magnitude of proteinuria is associated with a graded increase in the risk of progression to end-stage renal disease and cardiovascular events." | 2.71 | The relationship between magnitude of proteinuria reduction and risk of end-stage renal disease: results of the African American study of kidney disease and hypertension. ( Bakris, GL; Greene, T; Hebert, L; Lea, J; Lipkowitz, M; Massry, S; Middleton, J; Miller, E; Rostand, SG; Smith, W, 2005) |
| " The adverse effects studied comprised effects related to the central nervous system, cardiovascular effects, and sexual dysfunction." | 2.71 | Impact of CYP2D6 genotype on adverse effects during treatment with metoprolol: a prospective clinical study. ( Delabar, U; Eichelbaum, M; Fux, R; Gleiter, CH; Kivistö, KT; Lorenz, G; Mörike, K; Pröhmer, AM; Schaeffeler, E; Schwab, M, 2005) |
| "The influence of chronic renal failure on the stereoselective metabolism of rac-metoprolol was investigated in 15 hypertensive patients, 7 of them with chronic renal failure and 8 with normal renal function." | 2.71 | Influence of chronic renal failure on stereoselective metoprolol metabolism in hypertensive patients. ( Cerqueira, PM; Coelho, EB; Geleilete, TJ; Goldman, GH; Lanchote, VL, 2005) |
| "Hypertension is a leading cause of end-stage renal disease (ESRD) in the United States, with no known treatment to prevent progressive declines leading to ESRD." | 2.70 | Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: results from the AASK trial. ( Agodoa, LY; Appel, LJ; Bakris, G; Charleston, J; Cheek, D; Douglas-Baltimore, JG; Gassman, J; Glassock, R; Greene, T; Hebert, L; Jamerson, K; Lewis, J; Middleton, JP; Phillips, RA; Rostand, SG; Toto, RD; Wright, JT, 2002) |
| "Obesity is a significant risk factor for hypertension and the cardiovascular sequelae of hypertension." | 2.69 | The effect of weight loss intervention on antihypertensive medication requirements in the hypertension Optimal Treatment (HOT) study. ( Adair, CT; Anderson, DC; Cameron, ME; Jones, DW; King, NS; Miller, ME; Willoughby, DL; Wofford, MR, 1999) |
| " A secondary aim was to relate the efficacy of the free and fixed combinations with pharmacokinetic profiles." | 2.69 | The pharmacodynamic and pharmacokinetic profiles of controlled-release formulations of felodipine and metoprolol in free and fixed combinations in elderly hypertensive patients. ( Elliott, HL; Hosie, J; MacDonald, TM; McLay, JS, 2000) |
| "Chronic left ventricular hypertrophy (LVH) is associated with depressed contractile performance, abnormal compliance of the chamber, and ultimately, the development of a left ventricular failure." | 2.68 | [The effect of hypotensive drugs on left ventricular mass and diastolic function]. ( Haczyński, J; Jołda-Mydłowska, B; Spring, A; Witkowska, M, 1995) |
| "Hypertension is a constituent of the metabolic syndrome, although the rise of the blood sugar does not directly correlate with manifestation of type 2 diabetes, it is a warning that insulin resistance can influence the effectiveness of provisions of the therapeutic regimen, and last not least, also the development of type 2 diabetes." | 2.68 | [Glycemia increases during treatment of hypertension. 13 years' experience in the treatment of middle-aged men, randomized for treatment with beta blockers and diuretics]. ( Storková, H; Válek, J; Válková, L, 1996) |
| "Twenty patients with previously untreated hypertension who consecutively attended our outpatient hypertension clinic were included in this prospective, open, cross-over study." | 2.68 | Decreased blood viscosity and serum levels of erythropoietin after anti-hypertensive treatment with amlodipine or metoprolol: results of a cross-over study. ( Danielson, BG; Hägg, A; Linde, T; Mörlin, C; Sandhagen, B, 1996) |
| "Antihypertensive drug combinations have two major advantages: First, dosage of the single components can be reduced, and second, putative side effects can be minimized." | 2.68 | [Combination antihypertensive therapy in patients with an increased risk profile]. ( Bartens, W; Nauck, M; Wanner, C, 1996) |
| "Hypertension is a significant cause of end-stage renal failure and effective treatment of hypertensive will reduce the progression rate of chronic renal failure in various kidney disorders." | 2.68 | Enalapril versus metoprolol in primary hypertension--effects on the glomerular filtration rate. ( Aurell, M; Bengtsson, C; Björck, S, 1997) |
| "Tertatolol is a noncardioselective beta-blocker without intrinsic sympathomimetic activity." | 2.67 | The effects of tertatolol on lipid profile. ( Amendt, K; Diehm, C; Jacobsen, O, 1993) |
| " After 12 weeks of active treatment, reductions in supine systolic/diastolic blood pressure 24 h after dosing were 20/14, 13/10 and 11/8 mmHg with felodipine-metoprolol, felodipine and metoprolol, respectively." | 2.67 | Antihypertensive efficacy and tolerability of a new once-daily felodipine-metoprolol combination compared with each component alone. The Swedish/UK Study Group. ( Dahlöf, B; Hosie, J, 1993) |
| "Carvedilol is a novel non-selective beta-blocker without intrinsic sympathomimetic activity possessing vasodilatory properties primarily due to an alpha 1-antagonism in the same dose range." | 2.67 | Comparison of the antihypertensive effects of carvedilol and metoprolol on resting and exercise blood pressure. ( Agrawal, B; Franz, IW; Ketelhut, R; Wiewel, D, 1992) |
| " Significantly fewer adverse events were experienced on lisinopril and metoprolol than on diuretic treatment." | 2.67 | Quality of life, side effects and efficacy of lisinopril compared with metoprolol in patients with mild to moderate essential hypertension. ( Bech, P; Frimodt-Moeller, J; Kornerup, HJ; Poulsen, DL, 1991) |
| "Bopindolol is a nonselective beta blocker with mild intrinsic sympathomimetic activity." | 2.67 | Bopindolol: Czechoslovak experience with a new beta blocker in the treatment of hypertension. ( Dvorák, I; Fedelesová, V; Lefflerová, K; Lupínek, Z; Mayer, O; Pinterová, E; Widimský, J, 1991) |
| "Celiprolol is a 'third generation' beta-blocking agent which is claimed to avoid problems associated with simpler beta-blockers, such as vasoconstriction, bronchoconstriction and myocardial depression." | 2.67 | Acute haemodynamic profile of celiprolol in patients with coronary heart disease and hypertension: a double-blind comparison with metoprolol. ( Franz, N; Heublein, B; Modersohn, D; Panzner, B, 1991) |
| " Altogether, 251 hypertensive patients with a diastolic blood pressure greater than 95 mm Hg after 4 weeks of treatment with placebo in combination with metoprolol CR 100 mg were randomized to four parallel groups." | 2.67 | Optimal felodipine dose when combined with metoprolol in arterial hypertension: a Swedish multicenter study within primary health care. Swedish General Practitioner Felodipine Study Group. ( Bengtsson, C; Brun, J; Fröberg, L; Kronmann, P; Olsson, LB; Scherstén, B; Skoog, P; Tibblin, G; Tygesen, G, 1990) |
| "In a randomized double-blind multicenter study in 100 hypertensive patients, the effect of once daily (od) dosing with a new controlled release (CR/ZOK) formulation of metoprolol was compared with that of twice daily (bid) dosing with metoprolol conventional tablets." | 2.67 | A comparison of a controlled release (CR/ZOK) formulation of metoprolol, once daily, with conventional metoprolol tablets, twice daily, in mild to moderate hypertension. ( Carruthers, G; Moore, M; Shearer, R; Taylor, W, 1990) |
| "Metoprolol was also the most effective drug in decreasing the frequency of systolic pressure peaks greater than 180 mm Hg." | 2.67 | Comparison of the antihypertensive efficiency of nitrendipine, metoprolol, mepindolol and enalapril using ambulatory 24-hour blood pressure monitoring. ( Armstrong, VW; Buhr-Schinner, H; Kandt, M; Scheler, F; Schoel, G; Schrader, J; Warneke, G, 1990) |
| "When bendroflumethiazide was added the favourable effect of captopril on the blood lipids disappeared while the undesirable effect of metoprolol became more pronounced." | 2.67 | The effect of captopril and metoprolol as monotherapy or combined with bendroflumethiazide on blood lipids. ( Foss, OP; Jensen, EK, 1990) |
| "Carvedilol (BM 14190) is a new potent and well-tolerated beta-adrenoceptor antagonist with vasodilating properties." | 2.66 | Circadian antihypertensive profile of carvedilol (BM 14190). ( Distler, A; Gotzen, R; Meyer-Sabellek, W; Schulte, KL, 1987) |
| "More metoprolol-treated patients withdrew because of depression (6 vs less than 1%; p = 0." | 2.66 | Influence of beta 2 agonism and beta 1 and beta 2 antagonism on adverse effects and plasma lipoproteins: results of a multicenter comparison of dilevalol and metoprolol. ( Ahmad, S; Glasser, SP; Lucas, C; Lutz, LJ; Materson, BJ; Morledge, JH; Ramanathan, KB; Saunders, E; Schnaper, HW; Vlachakis, ND, 1989) |
| " They were submitted to clinical exam, stress testing and plasma lipids dosage before and after four weeks of treatment." | 2.66 | [Effect of beta blockers with intrinsic sympathomimetic activity on blood pressure and blood lipids in patients with essential hypertension]. ( Bellotti, G; Braga, A; Pileggi, F; Santomauro, A; Serro-Azul, JB; Serro-Azul, LG; Wajngarten, M; Yazbek Júnior, P, 1989) |
| "Treatment with labetalol, on the other hand, led to an improvement in respiratory function." | 2.66 | Respiratory effects of four adrenergic blocking agents combined with a diuretic in treating hypertension with concurrent chronic obstructive lung disease. ( Dal Negro, RW; Pomari, C; Trevisan, F; Turco, P; Zoccatelli, O, 1986) |
| "Celiprolol is a new generation beta blocker with a novel profile of activity that includes a high degree of cardioselectivity, partial beta 2-agonist activity, and possibly a degree of direct peripheral vasodilation." | 2.66 | Antihypertensive therapy with celiprolol: a new cardioselective beta blocker. ( Norris, RJ, 1988) |
| "Atenolol treatment generally resulted in performance levels that did not differ from those observed with placebo." | 2.66 | Impact of beta-blockade on complex cognitive functioning. ( DePadova, A; McGlynn, T; Piasecki, M; Pogash, R; Streufert, S, 1988) |
| "Ketanserin appears to be a new alternative approach in the treatment of mild and moderate essential hypertension." | 2.66 | Ketanserin versus metoprolol in the treatment of essential hypertension. ( Bernardiner, E; Lemus, J; Milei, J, 1986) |
| "The patients with complex arrhythmias were older (p less than 0." | 2.66 | Ventricular dysrhythmias in middle-aged hypertensive men treated either with a diuretic agent or a beta-blocker. ( Hardarson, T; Ragnarsson, J; Snorrason, SP, 1987) |
| " Blood pressure and heart rate were measured 22 hours after the last tablet of a 2-week dosing period." | 2.66 | Comparison of the duration of antihypertensive action of atenolol and metoprolol over a 24-hour period. ( Crowe, PF; Ferguson, RJ, 1985) |
| " Twenty-four hours after dosing only atenolol treatment was consistently associated with a reduction in both exercise heart rate (P less than 0." | 2.66 | Comparison of two slow-release formulations of metoprolol with conventional metoprolol and atenolol in hypertensive patients. ( Freestone, S; Lennard, MS; Ramsay, LE; Silas, JH, 1985) |
| "Propranolol was the only drug that significantly increased airways obstruction (FEV1, specific airways resistance)." | 2.65 | Labetalol, beta blockers, and acute deterioration of chronic airway obstruction. ( Adam, WR; Barter, CE; Meagher, EJ, 1982) |
| " Simplification of the dosage regimen to once-daily therapy appears to improve the patient's willingness to comply with the physician's instructions." | 2.65 | A study of efficacy, tolerance and compliance of once-daily versus twice-daily metoprolol (Betaloc) in hypertension. Betaloc Compliance Canadian Cooperative Study Group. ( Baird, MG; Bentley-Taylor, MM; Carruthers, SG; Dawson, KG; Laplante, LE; Larochelle, P; MacCannell, KL; Marquez-Julio, A; Silverberg, LR; Talbot, P, 1984) |
| "Propranolol L." | 2.65 | Long acting beta-blockers in the twenty fourth hour. ( Hackett, GI; Harrison, P; Kershaw, S, 1983) |
| " Patients who responded (diastolic BP less than 95 mmHg) continued on the initial dosage regimen." | 2.65 | Metoprolol and atenolol administered once daily in primary hypertension. A clinical comparison of the efficacy of two selective beta-adrenoceptor blocking agents. ( Lyngstam, O; Rydén, L, 1981) |
| "Thus, beta-blocker withdrawal symptoms are reproducible and are indicative of a transient sympathetic hyperresponse." | 2.65 | Abrupt withdrawal of beta-blocking agents in patients with arterial hypertension. Effect on blood pressure, heart rate and plasma catecholamines and prolactin. ( Christensen, NJ; Lanng Nielsen, J; Lederballe Pedersen, O; Mikkelsen, E, 1979) |
| "105 patients with previously untreated hypertension entered the trial and 72 completed it." | 2.65 | Double-blind comparison of metoprolol, alprenolol, and oxprenolol in hypertension. ( Nissinen, A; Tuomilehto, J, 1979) |
| " Dose-response curves of isoprenaline were constructed in nine hypertensive patients before and after either propranolol or metoprolol." | 2.64 | Effect of selective and non-selective beta-adrenoreceptor blockade on calf blood flow in hypertensive patients. ( Clement, DL, 1978) |
| "Metoprolol 120 mg/d was significantly superior to propranolol 240 mg/d in holding the diastolic supine blood pressure at less than or equal to 90 mmHg." | 2.64 | South African multicentre study of metoprolol and propranolol in essential hypertension. ( Bosman, AR; Goldberg, B; McKechnie, JK; Offermeier, J; Oosthuizen, OJ, 1977) |
| "Metoprolol was employed to investigate the preventive effect of beta-adrenergic blockade on the response to stress." | 2.64 | Beta-adrenergic blockade in stress protection. Limited effect of metoprolol in psychological stress reaction. ( Heidbreder, E; Heidland, A; Pagel, G; Röckel, A, 1978) |
| "Metoprolol is a widely used cardioselective beta-blocker." | 2.44 | S-metoprolol: the 2008 clinical review. ( Dasbiswas, A; Dasbiswas, D; Shinde, S, 2008) |
| "Hydrochlorothiazide (HCT) is a well-established diuretic and antihypertensive agent, which promotes natruresis by acting on the distal renal tubule." | 2.44 | Metoprolol succinate extended release/hydrochlorothiazide combination tablets. ( Hainer, JW; Sugg, J, 2007) |
| "Hypertension is the second leading attributable cause of end-stage renal disease in the United States today." | 2.43 | Lessons from the African-American Study of Kidney Disease and Hypertension: an update. ( Toto, RD, 2006) |
| "Metoprolol is a selective beta(1)-adrenergic antagonist extensively used in major fields of cardiology since 1975." | 2.42 | [Metoprolol CR/XL: advanced formulation of a classical beta-blocker]. ( Gudkov, KM; Kobalava, ZhD, 2003) |
| "The incidence of congestive heart failure is higher in diabetic patients, although the reasons for this increased rate are debated (higher incidence and severity of coronary heart disease and arterial hypertension, or a true diabetic cardiomyopathy)." | 2.41 | [Prevention and treatment of congestive heart failure in diabetic patients]. ( Anguita Sánchez, M, 2002) |
| "Type 2 diabetes is becoming very common and is closely linked to physical inactivity and obesity." | 2.41 | Beta-blockers and diabetes: the bad guys come good. ( Cruickshank, JM, 2002) |
| " In one study that titrated dosages to effect, fewer felodipine/metoprolol than felodipine or metoprolol monotherapy recipients required dosage increases to achieve BP control (45 vs 60 and 67%, respectively)." | 2.41 | Felodipine/metoprolol: a review of the fixed dose controlled release formulation in the management of essential hypertension. ( Haria, M; Markham, A; Plosker, GL, 2000) |
| "Metoprolol is a beta 1-selective adrenoceptor antagonist that is widely used in several indications." | 2.39 | Metoprolol: a pharmacoeconomic and quality-of-life evaluation of its use in hypertension, post-myocardial infarction and dilated cardiomyopathy. ( Benfield, P; Peters, DH, 1994) |
| " If standard doses of beta-blockers are used in PM subjects, they may be susceptible to concentration-related adverse reactions and they may also require lower and less frequent dosing for control of angina pectoris." | 2.37 | Oxidation phenotype and the metabolism and action of beta-blockers. ( Lennard, MS, 1985) |
| "The chronic use of propranolol is characterized by 10%-20% decrements of renal plasma flow (RPF) and glomerular filtration rate (GFR)." | 2.37 | Beta blockers and renal function: a reappraisal. ( Epstein, M; Oster, JR, 1985) |
| "Amiodarone is an extremely potent drug which is effective for both supraventricular as well as ventricular arrhythmias." | 2.36 | New antiarrhythmic drugs. ( Hess, DS; Scheinman, MM, 1983) |
| "Although drug treatment of hypertension is associated with improved survival and decreased vascular complications, drug compliance is a major problem in the control of hypertension." | 2.36 | Antihypertensive pharmacology. ( Freed, CR; Gerber, JG; Nies, AS, 1980) |
| "Metoprolol is a beta1-selective adrenoceptor blocking drug." | 2.36 | Metoprolol: a review of its pharmacological properties and therapeutic efficacy in hypertension and angina pectoris. ( Avery, GS; Brogden, RN; Heel, RC; Speight, TM, 1977) |
| "Hypertension is the most common chronic non-infectious disease and a severe problem for public health in China." | 1.91 | Estimating the prevalence of hypertension in 164 cities in China by wastewater-based epidemiology. ( Chen, M; Di, B; Hou, C; Hu, C; Liu, M; Su, M; Wang, Y; Xu, P; Yan, F; Zhang, L; Zhong, Y, 2023) |
| "Metoprolol is a cardioprotective anti-hypertensive agent." | 1.48 | Modulation of cardiac stem cell characteristics by metoprolol in hypertensive heart disease. ( Nair, RR; Potnuri, AG; Saheera, S, 2018) |
| " In a subset, the dose-response curves to bradykinin and sodium nitroprusside were repeated with a coinfusion of the antioxidant vitamin C." | 1.46 | Nebivolol, But Not Metoprolol, Treatment Improves Endothelial Fibrinolytic Capacity in Adults With Elevated Blood Pressure. ( Bammert, TD; DeSouza, CA; Diehl, KJ; Dow, CA; Greiner, JJ; Stauffer, BL, 2017) |
| "Our data show a potential pharmacokinetic interaction, most likely via CYP3A4 between amlodipine and RIS, reflected in significantly different C/Ds for RIS, 9-OH-RIS and AM." | 1.43 | Pharmacokinetic considerations in the treatment of hypertension in risperidone-medicated patients - thinking of clinically relevant CYP2D6 interactions. ( Gründer, G; Haen, E; Lammertz, SE; Paulzen, M; Schoretsanitis, G; Schruers, KR; Stegmann, B; Walther, S, 2016) |
| "Metoprolol is a selective β-1 adrenergic receptor blocker that undergoes extensive metabolism by the polymorphic enzyme cytochrome P450 2D6 (CYP2D6)." | 1.40 | Impact of CYP2D6 polymorphisms on clinical efficacy and tolerability of metoprolol tartrate. ( Burkley, BM; Chapman, AB; Cooper-DeHoff, RM; Dwivedi, R; Garcia, S; Gong, Y; Gums, JG; Hamadeh, IS; Johnson, JA; Langaee, TY; Skaar, TC; Turner, ST, 2014) |
| "Metoprolol and atenolol were generally well tolerated except at higher doses such as metoprolol >100 mg daily." | 1.38 | Cardioselective beta-blocker treatment of hypertension in patients with asthma: when do benefits outweigh risks? ( Self, TH; Soberman, JE; Wallace, JL, 2012) |
| "Treatment with metoprolol decreased systolic blood pressure at 21 months only but improved survival, decreased ventricular weight, prevented chamber dilation, reduced inflammation, decreased fibrosis, attenuated action potential prolongation, improved systolic and diastolic function, decreased stiffness and improved endothelium-independent vascular responses." | 1.37 | Chronic β-adrenoceptor antagonist treatment controls cardiovascular remodeling in heart failure in the aging spontaneously hypertensive rat. ( Brown, L; Chan, V; Fenning, A; Hoey, A, 2011) |
| "Metoprolol (MP) was given intravenously to reduce blood pressure during surgery." | 1.35 | Noradrenergic modulation of subthalamic nucleus activity in human: metoprolol reduces spiking activity in microelectrode recordings during deep brain stimulation surgery for Parkinson's disease. ( Abdel Rahman, A; Castro-Prado, F; Coenen, VA; Gielen, FL; Honey, CR, 2008) |
| "ER metoprolol was then added to their ongoing therapy." | 1.35 | Treatment with metoprolol succinate, a selective beta adrenergic blocker, lowers blood pressure without altering insulin sensitivity in diabetic patients. ( Falkner, B; Kushner, H, 2008) |
| "This study of metoprolol pharmacokinetic and pharmacodynamic properties investigates cardiac beta1-adrenoceptors activity and its involvement in the hypertensive stage in 6-week-old fructose-fed male Sprague-Dawley rats." | 1.35 | In vitro and in vivo pharmacodynamic properties of metoprolol in fructose-fed hypertensive rats. ( Di Verniero, CA; Höcht, C; Mayer, MA; Opezzo, JA; Silberman, EA; Taira, CA, 2008) |
| " As comparisons to metoprolol succinate as well as to optimally dosed metoprolol tartrate are missing, a definite superiority of carvedilol cannot be assumed." | 1.34 | [Beta-adrenoceptor antagonists and ACE-inhibitors. Carvedilol compared with metoprolol as combination partner in cases of diabetes and hypertension]. ( Frese, T; Sandholzer, H, 2007) |
| "Metoprolol treatment of hypertensive patients with hepatic cirrhosis resulted in development of bradycardia." | 1.34 | [Pharmacokinetics of enalapril and metoprolol in hypertensive patients with hepatic pathology]. ( Drozdov, VN; Lazebnik, LB; Mikheeva, OM; Petrakov, AV; Sil'vestrova, SIu, 2007) |
| "The present work addressed possible alterations in the pharmacokinetics and the in vivo pharmacodynamic of metoprolol (MET) in spontaneously hypertensive (SH) rats and Wistar Kyoto (WKY) animals by means of the microdialysis technique." | 1.33 | Pharmacokinetic-pharmacodynamic (PK-PD) modeling of cardiovascular effects of metoprolol in spontaneously hypertensive rats: a microdialysis study. ( Bramuglia, GF; Di Verniero, C; Höcht, C; Opezzo, JA; Taira, CA, 2006) |
| "Beta-Blocker use can be associated with adverse effects that may have an impact on adherence or harm patients." | 1.32 | Pharmacokinetics and CYP2D6 genotypes do not predict metoprolol adverse events or efficacy in hypertension. ( Beitelshees, AL; Eberst, K; Gaedigk, A; Gelfand, CA; Johnson, JA; Leeder, JS; Pauly, DF; Phillips, MS; Walker, JR; Zineh, I, 2004) |
| "Pheochromocytomas are functionally active, catecholamine-secreting tumours of chromaffin tissue." | 1.30 | [Intraoperative diagnosis of a multilocal pheochromocytoma]. ( Egelhof, J; Engelhardt, D; Fürst, H; Welte, M, 1997) |
| "Indications for treatment were hypertension (75%), coronary artery disease with (12%) or without (3%) hypertension, or unknown (10%)." | 1.30 | Beta adrenergic blockers lower renin in patients treated with ACE inhibitors and diuretics. ( Danser, AH; Hense, HW; Holmer, SR; Mayer, B; Riegger, GA; Schunkert, H, 1998) |
| " The pharmacokinetic parameters and the PK-PD model parameters were calculated." | 1.30 | Pharmacokinetic-pharmacodynamic modeling of metoprolol stereoisomers in spontaneously hypertensive rat. ( Ding, Y; Huang, DK; Huang, XP; Luo, JP; Shen, JP; Yin, XX; Zhang, YD, 1997) |
| "Metoprolol was without significant effect on any of these variables following chronic administration." | 1.30 | The beta2-adrenergic modulator celiprolol reduces insulin resistance in obese Zucker rats. ( Dietze, GJ; Fogt, DL; Henriksen, EJ; Jacob, S, 1999) |
| "Acute myocardial infarction is characterized by a more pronounced rise in plasma ANP concentration in hypertensive patients than in those without a history of hypertension." | 1.29 | Elevated plasma atrial natriuretic peptide concentrations in hypertensive patients with acute myocardial infarction. ( Górecki, A; Ignatowska-Switalska, H; Januszewicz, A; Kochanowski, J; Lapiński, M; Opolski, G; Stolarz, P; Słomka, K; Wocial, B, 1995) |
| "Felodipine was equally effective at both time points." | 1.29 | Time-dependent efficacy of antihypertensive agents in spontaneously hypertensive rats. ( Janssen, BJ; Oosting, J; Struyker-Boudier, HA; Tyssen, CM, 1993) |
| " In contrast, chronic administration of dihydralazine had no influence on GABA synthesis rate." | 1.29 | Enhancement of GABAergic system activity by metoprolol in spontaneously hypertensive rats. ( Czyzewska-Szafran, H; Jastrzebski, Z; Remiszewska, M; Wutkiewicz, M, 1993) |
| "Diagnosis of type I-aortic dissection according to DeBakey was achieved by transthoracal echocardiography and computed tomography." | 1.29 | Aortic dissection due to discontinuation of beta-blocker therapy. ( Anelli-Monti, M; Delgado, P; Eber, B; Kaufmann, P; Kullnig, P; Lueger, A; Tscheliessnigg, KH, 1993) |
| "To discover whether in hypertensives with left ventricular hypertrophy (LVH) the increased muscle mass will completely regress under antihypertensive treatment and drug dosage can in consequence be reduced." | 1.29 | [Decreasing the antihypertensive dosage during longterm treatment and complete regression of left ventricular hypertrophy]. ( Behr, U; Franz, IW; Ketelhut, R; Tönnesmann, U, 1996) |
| " Selection of the dosage was individual under the control of circulation parameters." | 1.28 | [The action of the new beta-adrenoblocker Lopressor on the hemodynamics of hypertension patients]. ( Maev, IV; V'iuchnova, ES, 1992) |
| "Treatment with clonidine reduced both circadian variability of BP and HR and the awakening increase." | 1.28 | Modification of circadian blood pressure and heart rate variability by five different antihypertensive agents in spontaneously hypertensive rats. ( Janssen, BJ; Struyker-Boudier, HA; Tyssen, CM, 1991) |
| " The terminal plasma half-life (t1/2) on day 29 was 22 hours and systemic clearance was 490 mL/min on day 1 and 434 mL/min on day 29 (NS)." | 1.28 | Acute and steady-state pharmacokinetics and antihypertensive effects of felodipine in patients with normal and impaired renal function. ( Aberg, J; Gelin, A; Karlberg, BE; Larsson, R; Regårdh, CG, 1990) |
| "Metoprolol was given in doses of 100 to 400 mg/day (average dose, 167 mg/day in two divided doses) and significantly reduced both casual, office blood pressure (150/101 to 130/86 mm Hg, p less than 0." | 1.28 | Regression of left ventricular mass is accompanied by improvement in rapid left ventricular filling following antihypertensive therapy with metoprolol. ( Karimeddini, MK; Schulman, P; Smith, VE; White, WB, 1989) |
| "Patients with sleep apnea and essential hypertension need special attention paid to their antihypertensive therapy because the following side effects of drugs have to be avoided: increases of cardiac insufficiency, hyperviscosity of the blood, intensification of the hypersomnia by central sedation, intensification of a pre-existing tendency towards arrhythmias, and deprivation of deep and rapid eye movement sleep." | 1.28 | Effects of cilazapril on hypertension, sleep, and apnea. ( Gassel, W; Herrer-Mayer, B; Mayer, J; Penzel, T; Peter, JH; Schneider, H; von Wichert, P; Weber, K; Weichler, U, 1989) |
| "Metoprolol treatment caused an 8% decrease in heart rate and a 13% decrease in blood pressure and led to a rise in plasma triglycerides, 24%, 17% and 34% after 1, 3 and 6 months of metoprolol treatment, respectively." | 1.28 | Effect of metoprolol on plasma lipids and arterial intimal lipid deposition in spontaneously hypertensive rats. ( Eklund, A; Jönsson, L; Ostlund-Lindqvist, AM; Sjöblom, L, 1989) |
| "02) and practically unchanged after metoprolol, at a time and at a drug dosage when only minor changes in blood pressure and serum lipids were detectable." | 1.28 | Adrenergic blocking agents and lipoprotein lipase activity. ( De Simone, B; Ferrara, LA; Leccia, G; Marotta, T; Rubba, P; Soro, S, 1989) |
| "Three months after colectomy for severe ulcerative colitis, an 18-year-old male presented with a multisystem illness characterized by fever, arthralgias, hypertension, and declining renal function." | 1.27 | Polyarteritis nodosa associated with ulcerative colitis. ( Silverman, MH, 1984) |
| "More metoprolol-treated than placebo-treated patients withdrew because of cardiovascular adverse experience mainly during the very early phase." | 1.27 | Göteborg Metoprolol Trial: tolerance. ( Herlitz, J; Hjalmarson, A; Pennert, K; Vedin, A; Wedel, H; Wilhelmsen, L; Wilhelmsson, C, 1984) |
| " PRA activity was significantly and markedly reduced by both bunolol and metoprolol shortly after dosing at a time when HR was significantly reduced but MBP was not." | 1.27 | Antihypertensive effects of 12 beta adrenoceptor antagonists in conscious spontaneously hypertensive rats: relationship to changes in plasma renin activity, heart rate and sympathetic nerve function. ( Antonaccio, MJ; DeForrest, JM; High, J; Sybertz, E, 1986) |
| " If standard doses of some beta-blockers are used in poor metabolizers, these patients may be susceptible to concentration-related adverse reactions and they may also require lower and less frequent dosing for control of angina pectoris." | 1.27 | Debrisoquine polymorphism and the metabolism and action of metoprolol, timolol, propranolol and atenolol. ( Lennard, MS; Silas, JH; Tucker, GT; Woods, HF, 1986) |
| "The felodipine-induced increase of heart rate (HR) persisted for 90 min, but the increase of stroke volume was only transient." | 1.27 | The use of Doppler echocardiography to assess the acute haemodynamic response to felodipine and metoprolol in hypertensive patients. ( Amery, A; Fagard, R; Staessen, J, 1987) |
| "The ultimate goal in the treatment of hypertension is, of course, reduction of cardiovascular morbidity and mortality, but normalization of structural cardiovascular changes is clearly the second most important therapeutic goal." | 1.27 | The role of antihypertensive pharmacologic treatment in countering adverse pathophysiological profiles: influence on small arteries. ( Dahlöf, B, 1987) |
| " What remains to be solved is the dosage level." | 1.26 | Clinical experiences with prenalterol as an antidote to Beta-adrenoceptor blockade. ( Kulling, P, 1982) |
| " We can look forward to newer agents that are efficacious as monotherapy and on a daily or twice daily dosage regimen for the treatment of the vast majority of hypertensive patients." | 1.26 | Newer antihypertensive agents. ( Thind, GS, 1980) |
| "Labetalol, which is a combined alpha- and beta-blocking agent, reduces mean blood pressure levels at all times." | 1.26 | Effects of treatment on circadian rhythms of blood pressure. ( Balasubramanian, V; Mann, S; Millar-Craig, MW; Raftery, EB, 1981) |
| "Peyronie's disease has been observed in relation to treatment with other adrenergic blocking agents, including practolol, and the S." | 1.26 | Peyronie's disease and systemic lupus erythematosus syndrome associated with metoprolol administration: a case report. ( Paladini, G, 1981) |
| "The kinetics and dose-response characteristics of metoprolol were examined in a series of hypertensive patients." | 1.26 | Metoprolol kinetics and dose response in hypertensive patients. ( Myers, MG; Thiessen, JJ, 1980) |
| "Propranolol did not cause this pressor effect in prehypertensive (seven week old) SHRs." | 1.26 | Beta-adrenergic receptor blocking drugs in spontaneous hypertension. ( Levy, JV, 1976) |
| " The results indicate that metoprolol in a dosage of 150-450 mg daily is an effective and well tolerated therapy both in patients previously untreated and in patients unsatisfactorily treated with other antihypertensive agents." | 1.26 | Antihypertensive effect and tolerability of metoprolol during long-term treatment: a multicentre study. ( Rosengard, S, 1977) |
| " During long-term use alpha-methyldopa frequently reduces the total peripheral resistance and the reduction in cardiac output is usually modest, at rest as well as during exercise." | 1.26 | alpha-Methyldopa and beta-blockers in hypertension--a comparison of their haemodynamic effects. ( Lund-Johansen, P, 1978) |
| "3." | 1.26 | Prevention and reversal of isolation-induced systolic arterial hypertension in rats by treatment with beta-adrenoceptor antagonists. ( Bennett, T; Gardiner, SM, 1979) |
| " Follow-up a year later produced no evidence of unusual side effects but there was a reduction in the mean daily dosage without loss of efficacy." | 1.26 | The first year of metroprolol (Lopresor): an analysis of a newly released drug in general practice. ( Duncan, T; Stephens, EJ, 1979) |
| "Minoxidil seems to be a safe and potent antihypertensive drug for long-term use in severe arterial hypertension, but it cannot be recommended for routine treatment." | 1.26 | Long-term experiences with minoxidil in combination treatment of severe arterial hypertension. ( Lederballe Pedersen, O, 1977) |
| "Metoprolol was well tolerated and the relatively rare side-effects decreased in the course of the 6 weeks' therapy." | 1.26 | [Studies on the antihypertensive effect of metoprolol in practice. Results of a cooperative study by 1296 general practitioners (author's transl)]. ( Klinnert, U, 1978) |
| " The mean resting blood pressures were 168/108 mmHg, 151/98 mmHg and 150/96 mmHg at pre-trial, after the twice-daily dosage period and after the once-daily dosage period, respectively." | 1.26 | A fixed combination of metoprolol and hydrochlorothiazide for hypertension: a multi-centre study. ( Goodfellow, RM, 1979) |
| "Treatment with metoprolol, 50--150 mg three times daily for 4--17 weeks, had no effect on the plasma level of glycerol, free fatty acids, triglycerides or glucose under basal conditions, neither in the supine nor in the upright position." | 1.26 | Effect of metoprolol on blood glycerol, free fatty acids, triglycerides and glucose in relation to plasma catecholamines in hypertensive patients at rest and following submaximal work. ( Hansson, BG; Hökfelt, B; Nilsson, A, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 527 (53.72) | 18.7374 |
| 1990's | 189 (19.27) | 18.2507 |
| 2000's | 141 (14.37) | 29.6817 |
| 2010's | 107 (10.91) | 24.3611 |
| 2020's | 17 (1.73) | 2.80 |
| Authors | Studies |
|---|---|
| Sarkar, G | 1 |
| Gaikwad, VB | 1 |
| Sharma, A | 1 |
| Halder, SK | 1 |
| Kumar, DA | 1 |
| Anand, J | 1 |
| Agrawal, S | 1 |
| Kumbhar, A | 1 |
| Kinholkar, B | 1 |
| Mathur, R | 1 |
| Doshi, M | 1 |
| Bachani, D | 1 |
| Mehta, S | 1 |
| Liu, C | 1 |
| Xu, J | 3 |
| Liu, R | 1 |
| Wang, M | 1 |
| Zhuo, Y | 1 |
| Su, L | 1 |
| Yan, H | 1 |
| Zhang, Q | 1 |
| Vouri, SM | 1 |
| Morris, EJ | 1 |
| Jiang, X | 2 |
| Hofer, AK | 1 |
| Schmidt, S | 1 |
| Pepine, C | 1 |
| Winterstein, AG | 1 |
| Smith, SM | 1 |
| Huck, DM | 1 |
| Rosenberg, MA | 1 |
| Stauffer, BL | 2 |
| Ghazi, L | 1 |
| Li, F | 1 |
| Chen, X | 4 |
| Simonov, M | 1 |
| Yamamoto, Y | 2 |
| Biswas, A | 1 |
| Hanna, J | 1 |
| Shah, T | 1 |
| Peixoto, AJ | 1 |
| Wilson, FP | 1 |
| Gungor, G | 1 |
| Perk, H | 1 |
| Soyupek, S | 1 |
| Baykal, B | 1 |
| Demir, M | 1 |
| Sezer, MT | 1 |
| Lee, CM | 2 |
| Kang, P | 1 |
| Cho, CK | 1 |
| Park, HJ | 1 |
| Lee, YJ | 1 |
| Bae, JW | 1 |
| Choi, CI | 1 |
| Kim, HS | 1 |
| Jang, CG | 1 |
| Lee, SY | 1 |
| Esler, M | 1 |
| Kjeldsen, SE | 1 |
| Pathak, A | 1 |
| Grassi, G | 2 |
| Kreutz, R | 1 |
| Mancia, G | 2 |
| Hou, C | 1 |
| Zhong, Y | 1 |
| Zhang, L | 3 |
| Liu, M | 1 |
| Yan, F | 1 |
| Chen, M | 1 |
| Wang, Y | 1 |
| Xu, P | 1 |
| Su, M | 1 |
| Hu, C | 1 |
| Di, B | 1 |
| Chen, C | 2 |
| Zhang, W | 2 |
| Jiao, D | 1 |
| Shen, J | 1 |
| Zhu, G | 1 |
| Zhang, X | 1 |
| Singh, S | 2 |
| Warren, HR | 1 |
| Hiltunen, TP | 1 |
| McDonough, CW | 2 |
| El Rouby, N | 1 |
| Salvi, E | 1 |
| Wang, Z | 4 |
| Garofalidou, T | 1 |
| Fyhrquist, F | 1 |
| Kontula, KK | 1 |
| Glorioso, V | 1 |
| Zaninello, R | 1 |
| Glorioso, N | 2 |
| Pepine, CJ | 2 |
| Munroe, PB | 1 |
| Turner, ST | 5 |
| Chapman, AB | 4 |
| Boerwinkle, E | 3 |
| Johnson, JA | 9 |
| Gong, Y | 5 |
| Cooper-DeHoff, RM | 5 |
| Wei, J | 1 |
| Ma, W | 1 |
| Yao, G | 1 |
| Jia, Q | 1 |
| Cheng, X | 1 |
| Ouyang, H | 1 |
| Chang, Y | 1 |
| He, J | 1 |
| Kayser, A | 1 |
| Beck, E | 1 |
| Hoeltzenbein, M | 1 |
| Zinke, S | 1 |
| Meister, R | 1 |
| Weber-Schoendorfer, C | 1 |
| Schaefer, C | 1 |
| Leung, KL | 1 |
| Fong, W | 1 |
| Freedman, B | 1 |
| Bajorek, B | 1 |
| Lee, VWY | 1 |
| Brocker, CN | 1 |
| Velenosi, T | 1 |
| Flaten, HK | 1 |
| McWilliams, G | 1 |
| McDaniel, K | 1 |
| Shelton, SK | 1 |
| Saben, J | 1 |
| Krausz, KW | 1 |
| Gonzalez, FJ | 1 |
| Monte, AA | 1 |
| Ghafarzadeh, M | 1 |
| Shakarami, A | 1 |
| Yari, F | 1 |
| Namdari, P | 1 |
| Pearson, JT | 1 |
| Thambyah, HP | 1 |
| Waddingham, MT | 1 |
| Inagaki, T | 1 |
| Sukumaran, V | 1 |
| Ngo, JP | 1 |
| Ow, CPC | 1 |
| Sonobe, T | 1 |
| Chen, YC | 1 |
| Edgley, AJ | 1 |
| Fujii, Y | 1 |
| Du, CK | 1 |
| Zhan, DY | 1 |
| Umetani, K | 1 |
| Kelly, DJ | 1 |
| Tsuchimochi, H | 1 |
| Shirai, M | 1 |
| Wagmann, L | 1 |
| Vollmer, AC | 1 |
| Lauder, L | 1 |
| Mahfoud, F | 1 |
| Meyer, MR | 1 |
| Bin Jardan, YA | 1 |
| Ahad, A | 1 |
| Raish, M | 1 |
| Alam, MA | 1 |
| Al-Mohizea, AM | 1 |
| Al-Jenoobi, FI | 1 |
| Muniyappa, A | 1 |
| Goldschlager, N | 1 |
| Duan, L | 1 |
| Ng, A | 1 |
| Chen, W | 1 |
| Spencer, HT | 1 |
| Nguyen, J | 1 |
| Shen, AY | 1 |
| Lee, MS | 1 |
| Skrzypecki, J | 1 |
| Gawlak, M | 1 |
| Huc, T | 1 |
| Szulczyk, P | 1 |
| Ufnal, M | 1 |
| Zhang, Y | 2 |
| Sun, N | 1 |
| Xi, Y | 1 |
| Juraschek, SP | 2 |
| Appel, LJ | 4 |
| Miller, ER | 4 |
| Mehanna, M | 1 |
| Beitelshees, AL | 5 |
| Gums, JG | 4 |
| Schwartz, GL | 1 |
| Dow, CA | 1 |
| Diehl, KJ | 1 |
| Bammert, TD | 1 |
| Greiner, JJ | 1 |
| DeSouza, CA | 1 |
| Zoltowska, DM | 1 |
| Agrawal, Y | 1 |
| Kalavakunta, JK | 1 |
| Saheera, S | 2 |
| Potnuri, AG | 2 |
| Nair, RR | 2 |
| Velibey, Y | 1 |
| Yaylak, B | 1 |
| Guvenc, TS | 1 |
| Cinier, G | 1 |
| Kalenderoglu, K | 1 |
| Guzelburc, O | 1 |
| Yildirimturk, O | 1 |
| Eibel, B | 1 |
| Kristochek, M | 1 |
| Peres, TR | 1 |
| Dias, LD | 1 |
| Dartora, DR | 1 |
| Casali, KR | 1 |
| Kalil, RAK | 1 |
| Lehnen, AM | 1 |
| Irigoyen, MC | 1 |
| Markoski, MM | 1 |
| Ayyagari, R | 1 |
| Xie, J | 2 |
| Cheng, D | 1 |
| Wu, EQ | 2 |
| Huang, XY | 1 |
| Chen, S | 5 |
| Shi, J | 1 |
| Yuan, Y | 1 |
| Deng, X | 1 |
| Pan, Y | 1 |
| He, M | 1 |
| Liu, G | 2 |
| Sun, D | 1 |
| Wang, J | 3 |
| Wang, W | 2 |
| Li, Y | 5 |
| Egan, B | 1 |
| Flack, J | 1 |
| Patel, M | 1 |
| Lombera, S | 1 |
| Allakonda, L | 1 |
| Appavoo, A | 1 |
| Mukamal, KJ | 1 |
| Lipsitz, LA | 1 |
| Johannsen, JO | 1 |
| Reuter, H | 1 |
| Hoffmann, F | 1 |
| Blaich, C | 1 |
| Wiesen, MHJ | 1 |
| Streichert, T | 1 |
| Müller, C | 1 |
| Youmans, QR | 1 |
| Unger, ED | 1 |
| Benzuly, KH | 1 |
| Solayman, MH | 1 |
| Langaee, TY | 2 |
| Shahin, MH | 2 |
| El-Hamamsy, M | 1 |
| El-Wakeel, L | 1 |
| Badary, OA | 1 |
| Rouby, NE | 1 |
| Conrado, DJ | 1 |
| Gonzalez, D | 1 |
| Lobmeyer, MT | 1 |
| Chapman, A | 1 |
| Xiang, D | 1 |
| He, S | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Use of Determination of Drug Levels to Optimize Pharmacotherapy of Heart Failure[NCT06035978] | Phase 4 | 100 participants (Anticipated) | Interventional | 2023-11-30 | Not yet recruiting | ||
| Pharmacogenetic Prediction of Metoprolol Effectiveness[NCT02293096] | 462 participants (Actual) | Interventional | 2014-09-30 | Terminated (stopped due to Study was terminated due to the change in funding.) | |||
| African American Study of Kidney Disease and Hypertension ABPM Pilot Study[NCT00582777] | Phase 2/Phase 3 | 180 participants (Anticipated) | Interventional | 2007-11-30 | Completed | ||
| Nebivolol and Endothelial Regulation of Fibrinolysis[NCT01595516] | Phase 4 | 44 participants (Actual) | Interventional | 2012-02-29 | Completed | ||
| Effects of Nebivolol Versus Metoprolol on Blood Flow Responses to Exercise and Angiotensin II in Hypertensive Patients[NCT01502787] | Phase 4 | 46 participants (Actual) | Interventional | 2009-04-30 | Completed | ||
| Pharmacogenomic Evaluation of Antihypertensive Responses 2[NCT01203852] | Phase 4 | 839 participants (Actual) | Interventional | 2010-08-31 | Completed | ||
| An Observational Study to Identify BEnefits After 24 Weeks of NEBILET®(Nebivolol) Administration For Essential hypertensIon Patients With Various Co-morbidities and Treatment Environments in KOREA.[NCT03847350] | 3,250 participants (Actual) | Observational | 2015-07-01 | Completed | |||
| Effect of Nebivolol on Oxidative Stress and Endothelial Progenitor Cells in Subjects With Hypertension[NCT01041287] | Phase 4 | 96 participants (Actual) | Interventional | 2009-12-31 | Completed | ||
| The Effect of Nebivolol on Endothelial Dysfunction in African Americans With Hypertension[NCT01049009] | Phase 4 | 91 participants (Actual) | Interventional | 2009-12-31 | Completed | ||
| Effects of Nebivolol on Microvascular Perfusion in the Skeletal Muscles During Exercise in Hypertensive Patients[NCT01501929] | Phase 4 | 32 participants (Actual) | Interventional | 2010-08-31 | Completed | ||
| 2%-Mepivacaine With Two Different Vasoconstrictors; 1:20.000 Levonordefrin or 1:100.000 Epinephrin for Local Anesthesia in Third Molar Surgery: A Comparative Randomized Clinical Trial[NCT02603198] | 30 participants (Anticipated) | Interventional | 2014-08-31 | Active, not recruiting | |||
| Safety of Local Dental Anesthesia in Patients With Cardiac Channelopathies[NCT03182777] | 31 participants (Actual) | Interventional | 2015-05-31 | Completed | |||
| Comparison the Effects of Nebivolol Versus Metoprolol Succinate on Endothelial Function and Large Artery Stiffness[NCT01248338] | Phase 4 | 80 participants (Actual) | Interventional | 2006-03-31 | Completed | ||
| Effect of Combined Antihypertensive Therapy on Blood Pressure and Sexual Function in Patients With Essential Hypertension[NCT01238705] | Phase 4 | 280 participants (Anticipated) | Interventional | 2008-04-30 | Recruiting | ||
| African American Study of Kidney Disease and Hypertension[NCT04364139] | Phase 3 | 1,094 participants (Actual) | Interventional | 1995-02-01 | Completed | ||
| Effect of Renin-angiotensin-system (RAS) Blocker Drugs on Chronic Kidney Disease (CKD) Progression in Elderly Patients With Non Proteinuric Nephropathies (PROERCAN01)[NCT03195023] | Phase 4 | 106 participants (Anticipated) | Interventional | 2015-06-30 | Recruiting | ||
| Genetically Determined Response to Atenolol in Patients With Persistent Atrial Fibrillation[NCT01719367] | 38 participants (Actual) | Interventional | 2013-01-31 | Completed | |||
| Multicentre Prospective Open Label Clinical Study to Evaluate the Effect of Personalized Therapy on Patients With Immunoglobulin A Nephropathy.[NCT04662723] | Phase 4 | 878 participants (Anticipated) | Interventional | 2023-05-01 | Recruiting | ||
| Alternative in Beta Blocker Intolerance; the ABBI Trial[NCT00893984] | Phase 4 | 6 participants (Actual) | Interventional | 2009-05-31 | Terminated (stopped due to Lack of patient recruitment) | ||
| A Safety, Tolerability and Pharmacokinetics Study of TOPROL-XL® (Metoprolol Succinate) Extended-release Tablets (Metoprolol CR/XL) in Hypertensive Pediatric Subjects: A Multicenter, Open-Label Extension of Protocol 307A[NCT00255502] | Phase 3 | 100 participants | Interventional | 2002-07-31 | Completed | ||
| Dose Ranging, Safety and Tolerability of TOPROL-XL® (Metoprolol Succinate) Extended-Release Tablets (Metoprolol CR/XL) in Hypertensive Pediatric Subjects: A Multicenter, Double-Blind, Placebo-Controlled, Randomized, Parallel-Group Study[NCT00255528] | Phase 3 | 144 participants | Interventional | 2002-07-31 | Completed | ||
| Valsartan Versus Amlodipine Effect on Left Ventricular Multidirectional Deformation and Adipocytokines Level in Hypertensive Patients: Speckle Tracking Echocardiography[NCT03990480] | Phase 4 | 230 participants (Actual) | Interventional | 2018-12-01 | Completed | ||
| Effects of Carvedilol and Metoprolol on Endothelial Function in Hypertensive Patients With Type 2 Diabetes Mellitus[NCT00123604] | Phase 4 | 36 participants (Actual) | Interventional | 2004-06-30 | Completed | ||
| Heart Rate Lowering Efficacy and Respiratory Safety of Ivabradine in Patients With Obstructive Airway Disease[NCT01365286] | Phase 4 | 40 participants (Actual) | Interventional | 2009-05-31 | Completed | ||
| A Multicenter Randomized Controlled Trial of Exercise in Aortic Dissection Survivors[NCT05610462] | 126 participants (Anticipated) | Interventional | 2023-01-01 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Participants with at least a 10% decrease in SBP (NCT02293096)
Timeframe: 4-6 weeks status post initiation
| Intervention | Participants (Count of Participants) |
|---|---|
| Metoprolol Succinate, Genotyping, Clinical Factors, and Phenotyping | 85 |
10 % decline from pre-initiation heart rate will considered a HR decline success. Number of of participants with at least 10% decline is reported. (NCT02293096)
Timeframe: 4-6 weeks
| Intervention | Participants (Count of Participants) |
|---|---|
| Metoprolol Succinate, Genotyping, Clinical Factors, and Phenotyping | 67 |
Occurrence of adverse drug events will be captured and stratified by ADRB1 genotype (strong responder, good responder, non-responder). (NCT02293096)
Timeframe: 6 weeks
| Intervention | participants with events (Number) | ||
|---|---|---|---|
| ADRB1 genotype: Strong Responder | ADRB1 genotype: Good Responder | ADRB1 genotype: Non-responder | |
| Metoprolol Succinate, Genotyping, Clinical Factors, and Phenotyping | 1 | 2 | 0 |
Occurrence of adverse drug events will be captured and stratified by CYP2D6 metabolizer status (Poor Metabolizer (PM), Extensive Metabolizer (EM), Intermediate Metabolizer (IM), and Ultra rapid Metabolizer). (NCT02293096)
Timeframe: 6 weeks
| Intervention | participants with events (Number) | |
|---|---|---|
| CYP2D6 metabolizer status: EM | Other Metabolizer Statuses | |
| Metoprolol Succinate, Genotyping, Clinical Factors, and Phenotyping | 3 | 0 |
(NCT01595516)
Timeframe: Diastolic blood pressure was measured before the 12 week drug or placebo intervention and after the 12 week drug or placebo intervention.
| Intervention | mmHg (Mean) | |
|---|---|---|
| Before Intervention | After Intervention | |
| Metoprolol | 87 | 79 |
| Nebivolol | 85 | 78 |
| Placebo | 85 | 81 |
Net endothelial release of t-PA antigen in response to BDK and BDK+C was calculated using the following equation: Net Release of t-PA Antigen=(Cv-Ca) x (FBF x [101-hematocrit/100]) where Cv and Ca represent the concentration of t-PA in the vein and artery respectively. A positive difference indicates a net release and a negative difference net uptake. Arterial and venous blood samples are collected simultaneously at baseline and each dose of the drug (BDK) and BDK+Vit C. t-PA concentration were determined by enzyme immunoassay. Hematocrit was measured in triplicate using the standard microhematocrit technique and corrected for trapped plasma volume within the trapped red blood cells. (NCT01595516)
Timeframe: t-PA release was measured before the 12 week drug intervention and after the 12 week drug intervention.
| Intervention | ng/100 mL tissue/min (Mean) | |||
|---|---|---|---|---|
| Amount of t-PA release to Saline | Amount of t-PA release to BDK 12.5 | Amount of t-PA release to BDK 25.0 | Amount of t-PA release to BDK 50.0 | |
| After Metoprolol: Saline | -1.3 | 16.4 | 31.3 | 49.9 |
| After Metoprolol: Vitamin C | -2.7 | 30.0 | 46.4 | 73.8 |
| Before Metoprolol: Saline | -2.7 | 10.1 | 24.5 | 45.0 |
| Before Metoprolol: Vitamin C | -2.5 | 31.1 | 47.1 | 82.4 |
Net endothelial release of t-PA antigen in response to bradykinin (BDK) and bradykinin+vitamin C (BDK+C) was calculated using the following equation: Net Release of t-PA Antigen=(Cv-Ca) x (FBF x [101-hematocrit/100]) where Cv and Ca represent the concentration of t-PA in the vein and artery respectively. A positive difference indicates a net release and a negative difference net uptake. Arterial and venous blood samples are collected simultaneously at baseline and each dose of the drug (BDK) and BDK+Vit C. t-PA concentration were determined by enzyme immunoassay. Hematocrit was measured in triplicate using the standard microhematocrit technique and corrected for trapped plasma volume within the trapped red blood cells. (NCT01595516)
Timeframe: t-PA release was measured before the 12 week drug intervention and after the 12 week drug intervention.
| Intervention | ng/100 mL tissue/min (Mean) | |||
|---|---|---|---|---|
| Amount of t-PA release to saline | Amount of t-PA release to BDK 12.5 | Amount of t-PA release to BDK 25.0 | Amount of t-PA release to BDK 50.0 | |
| After Nebivolol: Saline | -1.5 | 28.2 | 49.1 | 67.5 |
| After Nebivolol: Vitamin C | -3.8 | 38.1 | 54.2 | 79.9 |
| Before Nebivolol: Saline | -2.4 | 14.3 | 27.6 | 47.2 |
| Before Nebivolol: Vitamin C | -1.4 | 31.3 | 52.7 | 80.5 |
Net endothelial release of t-PA antigen in response to bradykinin (BDK) was calculated using the following equation: Net Release of t-PA Antigen=(Cv-Ca) x (FBF x [101-hematocrit/100]) where Cv and Ca represent the concentration of t-PA in the vein and artery respectively. A positive difference indicates a net release and a negative difference net uptake. Arterial and venous blood samples are collected simultaneously at baseline and each dose of the drug (BDK). t-PA concentration were determined by enzyme immunoassay. Hematocrit was measured in triplicate using the standard microhematocrit technique and corrected for trapped plasma volume within the trapped red blood cells. (NCT01595516)
Timeframe: t-PA release was measured before the 12 week drug or placebo intervention and after the 12 week drug or placebo intervention.
| Intervention | ng/100 mL tissue/min (Mean) | |||
|---|---|---|---|---|
| Amount of t-PA release to Saline | Amount of t-PA release to BDK 12.5 | Amount of t-PA release to BDK 25.0 | Amount of t-PA release to BDK 50.0 | |
| After Metoprolol | -1.9 | 16.6 | 31.2 | 52.7 |
| After Nebivolol | -1.8 | 25.2 | 46.4 | 72.8 |
| After Placebo | -0.9 | 17.6 | 32.7 | 52.9 |
| Before Metoprolol | -1.2 | 14.4 | 27.5 | 48.2 |
| Before Nebivolol | -1.2 | 15.7 | 29.1 | 47.2 |
| Before Placebo | -0.2 | 18.1 | 28.3 | 51.1 |
Resting heart rate in the seated position (NCT01595516)
Timeframe: Heart rate was measured before the 12 week drug or placebo intervention and after the 12 week drug or placebo intervention.
| Intervention | bpm (Mean) | |
|---|---|---|
| Before Intervention | After Intervention | |
| Metoprolol | 71 | 64 |
| Nebivolol | 64 | 58 |
| Placebo | 69 | 72 |
(NCT01595516)
Timeframe: Systolic blood pressure was measured before the 12 week drug or placebo intervention and after the 12 week drug or placebo intervention.
| Intervention | mmHg (Mean) | |
|---|---|---|
| Before Intervention | After Intervention | |
| Metoprolol | 138 | 125 |
| Nebivolol | 140 | 125 |
| Placebo | 138 | 135 |
(NCT01502787)
Timeframe: 12 weeks after initiation of metoprolol
| Intervention | mmHg (Mean) |
|---|---|
| Metoprolol | 114 |
| Nebivolol | 113 |
(NCT01502787)
Timeframe: 12 weeks
| Intervention | mmHg (Mean) |
|---|---|
| Initial Treatment With Metoprolol | 101 |
| Initial Treatment With Nebivolol | 103 |
(NCT01502787)
Timeframe: 12 weeks after each specified medication
| Intervention | ml/min (Mean) |
|---|---|
| First Intervention Metoprolol: 12 Weeks | 96 |
| Second Intervention Nebivolol: 24 Weeks | 105 |
Change in glucose after treatment with study medication (NCT01203852)
Timeframe: after 6-8 weeks treatment
| Intervention | mg/dL (Mean) | |
|---|---|---|
| glucose response to metoprolol (n=365) | glucose response to chlorthalidone (n=318) | |
| Adverse Metabolic Effects | 1.02 | 5.12 |
Response to blood pressure medication will be assessed by measuring blood pressure before and after treatment (NCT01203852)
Timeframe: after 6-8 weeks of treatment
| Intervention | mmHg (Mean) | |
|---|---|---|
| diastolic blood pressure response | systolic blood pressure response | |
| Chlorthalidone Only | -7.68 | -13.65 |
| Metoprolol + Chlorthalidone | -7.56 | -11.70 |
| Metorprolol Only | -7.97 | -7.45 |
The pulse wave velocity (PWV) system measured the velocity of the blood pressure waveform between the carotid and femoral arteries using a single-lead electrocardiogram and tonometer to measure the pressure pulse waveform sequentially at the two peripheral artery sites. PWV is calculated as PWV=distance (d)/time (t) and the unit of measure is reported as meters per second (m/s). (NCT01041287)
Timeframe: 3 months
| Intervention | meters per second (m/s) (Mean) |
|---|---|
| Nebivolol/ Metoprolol | 8.4 |
| Metoprolol/Nebivolol | 10.1 |
The pulse wave velocity (PWV) system measured the velocity of the blood pressure waveform between the carotid and femoral arteries using a single-lead electrocardiogram and tonometer to measure the pressure pulse waveform sequentially at the two peripheral artery sites. PWV is calculated as PWV=distance (d)/time (t) and the unit of measure is reported as meters per second (m/s). (NCT01041287)
Timeframe: 6 months
| Intervention | meters per second (m/s) (Mean) |
|---|---|
| Nebivolol/ Metoprolol | 9.1 |
| Metoprolol/Nebivolol | 9.8 |
The pulse wave velocity (PWV) system measured the velocity of the blood pressure waveform between the carotid and femoral arteries using a single-lead electrocardiogram and tonometer to measure the pressure pulse waveform sequentially at the two peripheral artery sites. PWV is calculated as PWV=distance (d)/time (t) and the unit of measure is reported as meters per second (m/s). (NCT01041287)
Timeframe: Baseline
| Intervention | meters per second (m/s) (Mean) |
|---|---|
| Nebivolol/ Metoprolol | 9.4 |
| Metoprolol/Nebivolol | 8.9 |
Forearm blood flow measured by venous occlusion plethysmography at rest, after administration of N(G)-monomethyl-L-arginine (L-NMMA) and tetraethylammonium chloride (TEA), after administration of L-NMMA, TEA, and acetylcholine, and after administration of L-NMMA, TEA, and exercise. Unit of Measure refers to volume of blood (mL) per 100 mL of forearm tissue per minute. (NCT01049009)
Timeframe: 12 weeks
| Intervention | mL/100 mL/min (Mean) | |||
|---|---|---|---|---|
| At rest | L-NMMA+TEA | L-NMMA+TEA+ACh | L-NMMA+TEA+exercise | |
| Metoprolol XL/Nebivolol | 2.679 | 2.221 | 7.562 | 11.574 |
| Nebivolol/Metoprolol XL | 2.739 | 1.963 | 5.376 | 7.377 |
Forearm blood flow measured by venous occlusion plethysmography at rest, after administration of N(G)-monomethyl-L-arginine (L-NMMA) and tetraethylammonium chloride (TEA), after administration of L-NMMA, TEA, and acetylcholine, and after administration of L-NMMA, TEA, and exercise. Unit of Measure refers to volume of blood (mL) per 100 mL of forearm tissue per minute. (NCT01049009)
Timeframe: 24 weeks
| Intervention | mL/100 mL/min (Mean) | |||
|---|---|---|---|---|
| At rest | L-NMMA+TEA | L-NMMA+TEA+ACh | L-NMMA+TEA+exercise | |
| Metoprolol XL/Nebivolol | 2.968 | 2.287 | 7.534 | 10.395 |
| Nebivolol/Metoprolol XL | 3.066 | 2.457 | 7.158 | 9.589 |
Endothelial cell (EC) was collected after a 20-guage angiocatheter was inserted into the contralateral forearm vein under sterile conditions. Three J-shaped vascular guidewires (St. Jude, St. Paul, MN) were advanced sequentially into the vein up to 10 cm. Endothelial cells were collected by gentle abrasion and placed into a dissociation buffer (0.5% bovine serum albumin, 2mM EDTA, and 100 ug/ml heparin in PBS). Endothelial cells were recovered from the tips of guide wires by repeated washing into collection tubes and subsequent centrifugation. EC were incubated with monoclonal antibodies against the polyclonal antibodies against NADPH oxidase p47 subunit. The intensity of staining was measured using fluorescence microscopy. (NCT01501929)
Timeframe: 12 weeks
| Intervention | Ratio human to HUVEC p47Phox expression (Mean) |
|---|---|
| Metoprolol | 0.47 |
| Nebivolol | 0.44 |
Microvascular perfusion of skeletal muscle were measured during handgrip at 20 cycle per minute after 12 weeks of metoprolol, and after 12 weeks of nebivolol (NCT01501929)
Timeframe: 12 weeks
| Intervention | video intensity units/ second (Median) |
|---|---|
| Metoprolol | 43.938 |
| Nebivolol | 74.584 |
After baseline vital signs and ECG are recorded, patients will be asked to perform a baseline standardized (modified Bruce) exercise protocol. Heart rate will be recorded during each stage of the exercise protocol. Patients will be asked to exercise to sub-maximal exertion. After the baseline exercise protocol, patients will be given a single dose of oral atenolol. After a two hour waiting period to allow for peak effect of atenolol, patients will repeat the exercise protocol. The primary study outcome measure will be the difference in pre- and post-atenolol ventricular rate response to exercise. The primary outcome measure will be compared in patients with various polymorphisms in genes that might play a role in the inter-individual response to atenolol. (NCT01719367)
Timeframe: after 5minutes of exercise
| Intervention | beats per minute (Mean) |
|---|---|
| Atenolol: Ancestral Alleles | -10 |
| Atenolol: Variant Carriers | -13 |
After baseline vital signs and ECG are recorded, patients will be asked to perform a baseline standardized (modified Bruce) exercise protocol. Heart rate will be recorded during each stage of the exercise protocol. Patients will be asked to exercise to sub-maximal exertion. After the baseline exercise protocol, patients will be given a single dose of oral atenolol. After a two hour waiting period to allow for peak effect of atenolol, patients will repeat the exercise protocol. The primary study outcome measure will be the difference in pre- and post-atenolol ventricular rate response to exercise. The primary outcome measure will be compared in patients with various polymorphisms in genes that might play a role in the inter-individual response to atenolol. (NCT01719367)
Timeframe: after 10 amd 15 minutes of exercise
| Intervention | beats per minute (Mean) | |
|---|---|---|
| After 10 minutes | After 15 minutes | |
| Atenolol: Ancestral Alleles | -11 | -25.5 |
| Atenolol: Variant Carriers | -19.7 | -35.2 |
(NCT00893984)
Timeframe: 30 Days
| Intervention | Participants (Count of Participants) |
|---|---|
| Nebivolol | 0 |
(NCT00893984)
Timeframe: 30 Days
| Intervention | Participants (Count of Participants) |
|---|---|
| Nebivolol | 0 |
Mild symptoms include weight gain, edema, and headaches (NCT00893984)
Timeframe: 30 Days
| Intervention | participants (Number) |
|---|---|
| Nebivolol | 1 |
(NCT00893984)
Timeframe: 30 Days
| Intervention | Participants (Count of Participants) |
|---|---|
| Nebivolol | 0 |
Flow mediated dilation is a measure of endothelial function. It is measured by the percent change in artery diameter (i.e. dilation), pre and post manual artery occlusion. (NCT00123604)
Timeframe: change from baseline to 5 months
| Intervention | percentage of change in dilation (Mean) |
|---|---|
| Carvedilol | 6.2 |
| Metoprolol | 4.1 |
52 reviews available for metoprolol and Blood Pressure, High
| Article | Year |
|---|---|
Diverse pharmacological properties, trial results, comorbidity prescribing and neural pathophysiology suggest European hypertension guideline downgrading of beta-blockers is not justified.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Atenolol; Cardiovascular Diseases; Comorbidity | 2022 |
Genome-Wide Meta-Analysis of Blood Pressure Response to β
Topics: ADP-ribosyl Cyclase; Adrenergic beta-1 Receptor Antagonists; Antigens, CD; Atenolol; Bisoprolol; Bla | 2019 |
Comparative efficacy of β-blockers on mortality and cardiovascular outcomes in patients with hypertension: a systematic review and network meta-analysis.
Topics: Adrenergic beta-Antagonists; Age Factors; Antihypertensive Agents; Atenolol; Coronary Disease; Human | 2017 |
Beers list: what's NOT on "tap" for the older adult.
Topics: Aged, 80 and over; Antiemetics; Antihypertensive Agents; Arthritis; Chlorpropamide; Confusion; Diabe | 2013 |
β-blockers: a review of their pharmacological and physiological diversity in hypertension.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Atenolol; Benzopyrans; Blood Pressure; Carbazo | 2014 |
[The benefits of carvedilol therapy in the treatment of patients with high cardiovascular risk].
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Antihypertensive Agents; Bisoprolol; Carbazoles; Cardi | 2016 |
S-metoprolol: the 2008 clinical review.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Humans; Hypertension; Metoprolol | 2008 |
[The POISE study].
Topics: Adrenergic beta-Antagonists; Bradycardia; Delayed-Action Preparations; Heart Arrest; Humans; Hyperte | 2008 |
Beta-adrenergic blocking agents and dental vasoconstrictors.
Topics: Adrenergic beta-Antagonists; Anesthesia, Dental; Anesthetics, Local; Bradycardia; Drug Interactions; | 2010 |
Beta-adrenergic blocking agents and dental vasoconstrictors.
Topics: Adrenergic beta-Antagonists; Anesthesia, Dental; Anesthetics, Local; Bradycardia; Drug Interactions; | 2010 |
Beta-adrenergic blocking agents and dental vasoconstrictors.
Topics: Adrenergic beta-Antagonists; Anesthesia, Dental; Anesthetics, Local; Bradycardia; Drug Interactions; | 2010 |
Beta-adrenergic blocking agents and dental vasoconstrictors.
Topics: Adrenergic beta-Antagonists; Anesthesia, Dental; Anesthetics, Local; Bradycardia; Drug Interactions; | 2010 |
[Evolution of oral drug forms of metoprolol: advantages of long acting modified release forms with modified release].
Topics: Administration, Oral; Adrenergic beta-1 Receptor Antagonists; Delayed-Action Preparations; Drug Desi | 2010 |
Carvedilol: a third-generation β-blocker should be a first-choice β-blocker.
Topics: Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Atenolol; Biomarkers; Carbazoles; Car | 2012 |
[Prevention and treatment of congestive heart failure in diabetic patients].
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Aged; Angiotensin II; Angiotensin | 2002 |
Beta-blockers and diabetes: the bad guys come good.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Atenolol; Bisoprolol; Coronary Disease; Diabet | 2002 |
[Metoprolol CR/XL: advanced formulation of a classical beta-blocker].
Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Contraindications; Heart Failure; Humans; Hyperte | 2003 |
[Metoprolol in the treatment of essential hypertension].
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Arteriosclerosis; Humans; Hypertension; Metopr | 2003 |
Early initiation of beta blockade in heart failure: issues and evidence.
Topics: Adrenergic beta-Antagonists; Carbazoles; Carvedilol; Heart Failure; Humans; Hypertension; Metoprolol | 2005 |
The role of the new beta-blockers in treating cardiovascular disease.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Atenolol; Benzopyrans | 2005 |
Lessons from the African-American Study of Kidney Disease and Hypertension: an update.
Topics: Adrenergic beta-Antagonists; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive | 2006 |
Methamphetamine abuse.
Topics: Adrenergic beta-Antagonists; Adult; Amphetamine-Related Disorders; Emergency Nursing; Emergency Trea | 2006 |
Metoprolol succinate extended release/hydrochlorothiazide combination tablets.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Delayed-Action Preparations; Drug Combinations | 2007 |
beta-Adrenoceptor antagonists: new drugs and new indications.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Atenolol; Glaucoma; Humans; Hypertension; Kinetics; Me | 1981 |
Beta-adrenergic antagonists in the treatment of patients with heart disease.
Topics: Acebutolol; Adrenergic beta-Agonists; Alprenolol; Animals; Arrhythmias, Cardiac; Bronchial Spasm; Ca | 1981 |
[Hemodynamic changes caused by beta-blocking agents with and without intrinsic sympathicomimetic activity and with and without cardioselective activity. Comparison of hypertensives at fixed and variable frequencies].
Topics: Adrenergic beta-Antagonists; Atenolol; Female; Hemodynamics; Humans; Hypertension; Male; Metoprolol; | 1982 |
beta-adrenergic blockade and diabetes mellitus. A review.
Topics: Adrenergic beta-Antagonists; Alprenolol; Blood Glucose; Catecholamines; Diabetes Mellitus, Type 1; D | 1983 |
Comparative review of beta-blocking agents.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Arrhythmias, Cardiac; Atenolol; Humans; Hypertension; | 1984 |
The use of beta-adrenergic blocking drugs in patients with myocardial infarction.
Topics: Adrenergic beta-Antagonists; Alprenolol; Angina Pectoris; Atenolol; Clinical Trials as Topic; Humans | 1984 |
New antiarrhythmic drugs.
Topics: Amiodarone; Angina Pectoris; Anti-Arrhythmia Agents; Blood Circulation; Bradycardia; Diltiazem; Half | 1983 |
[Exertion hypertension in coronary disease and its importance in prevention and rehabilitation].
Topics: Adult; Coronary Disease; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle | 1982 |
Antihypertensive pharmacology.
Topics: Adolescent; Adult; Antihypertensive Agents; Clonidine; Diazoxide; Diuretics; Guanethidine; Humans; H | 1980 |
[Comparison of metroprolol and labetalol. Antihypertensive activity at rest and during exertion and effect on some noninvasive parameters of cardiovascular function].
Topics: Adult; Clinical Trials as Topic; Ethanolamines; Female; Hemodynamics; Humans; Hypertension; Labetalo | 1981 |
Refractory cardiogenic shock and complete heart block after verapamil SR and metoprolol treatment. A case report.
Topics: Aged; Delayed-Action Preparations; Drug Therapy, Combination; Emergencies; Female; Heart Block; Huma | 1995 |
Approaches to meeting the criteria for fixed dose antihypertensive combinations. Focus on metoprolol.
Topics: Dose-Response Relationship, Drug; Drug Combinations; Felodipine; Humans; Hypertension; Metoprolol | 1995 |
Treatment with beta-blockers--the value of an even plasma concentration over 24 h.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Antihypertensive Agents; Atenolol; Blood Pressure | 1997 |
Metoprolol: a pharmacoeconomic and quality-of-life evaluation of its use in hypertension, post-myocardial infarction and dilated cardiomyopathy.
Topics: Cardiomyopathy, Dilated; Cost of Illness; Cost-Benefit Analysis; Economics, Pharmaceutical; Follow-U | 1994 |
Felodipine/metoprolol: a review of the fixed dose controlled release formulation in the management of essential hypertension.
Topics: Drug Therapy, Combination; Felodipine; Hemodynamics; Humans; Hypertension; Kidney; Metoprolol; Quali | 2000 |
[Use of metoprolol CR/ZOK in the cardiological practice].
Topics: Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; Cardiovascular Diseases; Clinical Trials | 2000 |
Primary prevention with beta-blockade in patients with hypertension: review of results and clinical implications.
Topics: Adrenergic beta-Antagonists; Atenolol; Benzothiadiazines; Clinical Trials as Topic; Data Interpretat | 1990 |
[Long-term utilization of beta-blockers in arterial hypertension].
Topics: Acebutolol; Adrenergic beta-Antagonists; Alprenolol; Blood Pressure; Coronary Disease; Drug Toleranc | 1978 |
Metoprolol: a review of its pharmacological properties and therapeutic efficacy in hypertension and angina pectoris.
Topics: Angina Pectoris; Animals; Blood Glucose; Dogs; Drug Interactions; Female; Hemodynamics; Humans; Hype | 1977 |
Drug therapy: metoprolol.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Disease; Hemodynamics; Humans; Hypertension; | 1979 |
Controlled release metoprolol formulations. A review of their pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension and ischaemic heart disease.
Topics: Biological Availability; Coronary Disease; Delayed-Action Preparations; Dose-Response Relationship, | 1992 |
Effects of coronary artery occlusion in animals with hypertension and left ventricular hypertrophy.
Topics: Animals; Arterial Occlusive Diseases; Cardiomegaly; Coronary Vessels; Dogs; Enalapril; Hemodynamics; | 1991 |
Controlled release metoprolol. Clinical pharmacokinetic and therapeutic implications.
Topics: Biological Availability; Delayed-Action Preparations; Hemodynamics; Humans; Hypertension; Metoprolol | 1991 |
Effect of antihypertensive drugs on insulin, glucose, and lipid metabolism.
Topics: Antihypertensive Agents; Atenolol; Blood Pressure; Captopril; Double-Blind Method; Glucose; Humans; | 1991 |
Tolerability and well-being with metoprolol in a controlled release (CR/ZOK) formulation: a review article.
Topics: Central Nervous System Diseases; Delayed-Action Preparations; Drug Tolerance; Humans; Hypertension; | 1990 |
Hypertension and beta-blockers. Are they all the same?
Topics: Adrenergic beta-Antagonists; Atenolol; Blood Pressure; Circadian Rhythm; Humans; Hypertension; Labet | 1985 |
Oxidation phenotype and the metabolism and action of beta-blockers.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Animals; Drug Interactions; Ethanolamines; Humans; Hyp | 1985 |
Enalapril in hypertension and congestive heart failure. Overall review of efficacy and safety.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Enalapril; Female | 1985 |
[Beta-blockaders in the treatment of hypertension in pregnancy].
Topics: Adrenergic beta-Antagonists; Atenolol; Drug Evaluation; Female; Humans; Hypertension; Metoprolol; Ox | 1985 |
Beta blockers and renal function: a reappraisal.
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Blood Urea Nitrogen; Cardiac Output; Creatinine; Dog | 1985 |
Metoprolol. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in hypertension, ischaemic heart disease and related cardiovascular disorders.
Topics: Adult; Age Factors; Aged; Arrhythmias, Cardiac; Cardiomegaly; Coronary Disease; Drug Interactions; D | 1986 |
New concepts in the treatment of elderly hypertensive patients.
Topics: Aged; Aging; Antihypertensive Agents; Clinical Trials as Topic; Heart Failure; Heart Ventricles; Hum | 1988 |
518 trials available for metoprolol and Blood Pressure, High
| Article | Year |
|---|---|
Fixed-dose Combination of Metoprolol, Telmisartan, and Chlorthalidone for Essential Hypertension in Adults with Stable Coronary Artery Disease: Phase III Study.
Topics: Adult; Amlodipine; Antihypertensive Agents; Blood Pressure; Chlorthalidone; Coronary Artery Disease; | 2022 |
Nebivolol protects erectile functions compared to Metoprolol in hypertensive men with atherogenic, venogenic, psychogenic erectile dysfunction: A prospective, randomized, cross-over, clinical trial.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Erectile Dysfunction; Ethanolamines; Humans; H | 2022 |
Metoprolol Increases Uric Acid and Risk of Gout in African Americans With Chronic Kidney Disease Attributed to Hypertension.
Topics: Adrenergic beta-1 Receptor Antagonists; Aged; Antihypertensive Agents; Biomarkers; Black or African | 2017 |
Metoprolol has a similar therapeutic effect as amlodipine on BP lowering in hypertensive patients with obstructive sleep apnea.
Topics: Administration, Oral; Adult; Aged; Amlodipine; Blood Pressure; Blood Pressure Monitoring, Ambulatory | 2019 |
Hypertension Treatment Effects on Orthostatic Hypotension and Its Relationship With Cardiovascular Disease.
Topics: Amlodipine; Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Cardiovascular Di | 2018 |
Effect of plasma MicroRNA on antihypertensive response to beta blockers in the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) studies.
Topics: Adrenergic beta-Antagonists; Adult; Antihypertensive Agents; Atenolol; Female; Humans; Hypertension; | 2019 |
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Topics: Adrenergic beta-Antagonists; Alleles; Atenolol; Black People; Female; Genotype; Heart Rate; Heterotr | 2019 |
[Cerebral blood flow and endothelial functional activity in patients with coronary heart disease and arterial hypertension during therapy with ivabradine in combination with perindopril].
Topics: Benzazepines; Blood Flow Velocity; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Cardiovasc | 2012 |
Differential effects of nebivolol versus metoprolol on functional sympatholysis in hypertensive humans.
Topics: Adrenergic beta-1 Receptor Antagonists; Benzopyrans; Blood Pressure; Cross-Over Studies; Double-Blin | 2013 |
Antihypertensive treatment improves microvascular rarefaction and reactivity in low-risk hypertensive individuals.
Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Angiotensin II Type 1 Receptor Blockers; Capillaries; | 2013 |
Effects of nebivolol on aortic compliance in patients with diabetes and maximal renin angiotensin system blockade: the EFFORT study.
Topics: Adrenergic beta-1 Receptor Antagonists; Aged; Angiotensin Receptor Antagonists; Angiotensin-Converti | 2013 |
The effect of combined antihypertensive treatment (felodipine with either irbesartan or metoprolol) on erectile function: a randomized controlled trial.
Topics: Adult; Antihypertensive Agents; Biphenyl Compounds; Drug Therapy, Combination; Erectile Dysfunction; | 2013 |
Comparative effects of nebivolol and metoprolol on red cell distribution width and neutrophil/lymphocyte ratio in patients with newly diagnosed essential hypertension.
Topics: Adult; Antihypertensive Agents; Benzopyrans; Blood Pressure; Double-Blind Method; Erythrocyte Indice | 2013 |
The effect of low-dose carvedilol, nebivolol, and metoprolol on central arterial pressure and its determinants: a randomized clinical trial.
Topics: Adolescent; Adrenergic beta-1 Receptor Antagonists; Adult; Aged; Arterial Pressure; Benzopyrans; Car | 2013 |
Effects of metoprolol and nebivolol on exercise blood pressure in patients with mild hypertension.
Topics: Antihypertensive Agents; Benzopyrans; Blood Pressure; Ethanolamines; Exercise Test; Female; Humans; | 2013 |
Effects of nebivolol versus metoprolol on sodium sensitivity and renal sodium handling in hypertensive Hispanic postmenopausal women.
Topics: Aged; Antihypertensive Agents; Benzopyrans; Blood Pressure; Cross-Over Studies; Ethanolamines; Femal | 2014 |
[Efficacy and safety of bisoprololal in hypertensive patients with cardiovascular disease and chronic obstructive pulmonary disease].
Topics: Adrenergic beta-1 Receptor Antagonists; Aged; Antihypertensive Agents; Bisoprolol; Cardiovascular Di | 2014 |
Nebivolol, but not metoprolol, lowers blood pressure in nitric oxide-sensitive human hypertension.
Topics: Adrenergic beta-1 Receptor Antagonists; Aged; Benzopyrans; Blood Pressure; Cross-Over Studies; Dose- | 2014 |
Effects of different antihypertensive drugs on blood pressure variability in patients with ischemic stroke.
Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Amlodipine; Antihypertensive Agents; Blood Pre | 2014 |
Influence of gestational diabetes on the stereoselective pharmacokinetics and placental distribution of metoprolol and its metabolites in parturients.
Topics: Adult; Antihypertensive Agents; Diabetes, Gestational; Female; Fetal Blood; Humans; Hypertension; In | 2015 |
Differential effects of nebivolol and metoprolol on arterial stiffness, circulating progenitor cells, and oxidative stress.
Topics: Antihypertensive Agents; Blood Pressure; Cross-Over Studies; Double-Blind Method; Drug Monitoring; F | 2015 |
Association of the ADRB2 (rs2053044) polymorphism and angiotensin-converting enzyme-inhibitor blood pressure response in the African American Study of Kidney Disease and Hypertension.
Topics: 5' Untranslated Regions; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Black or African Amer | 2015 |
Nitric Oxide Contributes to Vasomotor Tone in Hypertensive African Americans Treated With Nebivolol and Metoprolol.
Topics: Black or African American; Cross-Over Studies; Double-Blind Method; Forearm; Humans; Hypertension; M | 2016 |
Nebivolol Effects on Nitric Oxide Levels, Blood Pressure, and Renal Function in Kidney Transplant Patients.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Female; Glomerular Filtration Rate; Humans; Hy | 2016 |
Differential effects of nebivolol vs. metoprolol on microvascular function in hypertensive humans.
Topics: Adrenergic beta-1 Receptor Antagonists; Antihypertensive Agents; Cross-Over Studies; Endothelial Cel | 2016 |
Comparison of bisoprolol to a metoprolol CR/ZOK tablet for control of heart rate and blood pressure in mild-to-moderate hypertensive patients: the CREATIVE study.
Topics: Adult; Antihypertensive Agents; Bisoprolol; Blood Pressure; Blood Pressure Monitoring, Ambulatory; D | 2017 |
Cost-effectiveness of nitrendipine and hydrochlorothiazide or metoprolol to treat hypertension in rural community health centers in China.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Beijing; Blood Pressure; Community Health Centers; | 2017 |
Comparison of carvedilol and metoprolol on serum lipid concentration in diabetic hypertensive patients.
Topics: Adrenergic beta-Antagonists; Carbazoles; Carvedilol; Diabetes Mellitus, Type 2; Diabetic Angiopathie | 2009 |
Erectile dysfunction after therapy with metoprolol: the Hawthorne effect.
Topics: Adrenergic beta-Antagonists; Carbolines; Cross-Over Studies; Drug Interactions; Effect Modifier, Epi | 2009 |
Impact of beta-blockers on sleep in patients with mild hypertension: a randomized trial between nebivolol and metoprolol.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Benzopyrans; Blood Pressure; Delayed-Ac | 2008 |
Demographic analyses of the effects of carvedilol vs metoprolol on glycemic control and insulin sensitivity in patients with type 2 diabetes and hypertension in the Glycemic Effects in Diabetes Mellitus: Carvedilol-Metoprolol Comparison in Hypertensives (
Topics: Adrenergic beta-Antagonists; Adult; Age Factors; Aged; Aged, 80 and over; Blood Glucose; Blood Press | 2008 |
[Atenolol and metoprolol differentiated therapy of patients with arterial hypertension complicated by pathology of the digestive tract organs].
Topics: Antihypertensive Agents; Atenolol; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Bradycardi | 2008 |
[Efficacy and tolerability of metoprolol retard in the treatment of patients with arterial hypertension and ischemic heart disease combined with type 2 diabetes mellitus].
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Diabetes Mellitus, Type 2; Female; Humans; Hyp | 2009 |
Sleep quality in patients with hypertension: additional negative effect of drug therapy.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Benzopyrans; Delayed-Action Preparations; Etha | 2009 |
Antihypertensive efficacy of metoprolol XL/low dose chlorthalidone (6.25 mg) combination: a randomized, comparative study in indian patients with mild-to-moderate essential hypertension.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Chlorthalidone; Drug Therapy, Combination; Female; H | 2009 |
Effect of carvedilol on coronary flow reserve in patients with hypertensive left-ventricular hypertrophy.
Topics: Administration, Sublingual; Adrenergic beta-Antagonists; Aged; Blood Flow Velocity; Blood Pressure; | 2010 |
Comparison of Candesartan versus Metoprolol for treatment of systemic hypertension after repaired aortic coarctation.
Topics: Adrenergic beta-Antagonists; Adult; Angiotensin II Type 1 Receptor Blockers; Aortic Coarctation; Ben | 2010 |
Angiotensin-converting enzyme gene I/D genotype affected metoprolol-induced reduction in 24-hour average heart rate.
Topics: Adult; Aged; Antihypertensive Agents; Female; Genotype; Heart Rate; Humans; Hypertension; Male; Meto | 2010 |
[Effect between felodipine plus irbesartan and felodipine plus metoprolol regimen on the sexual function in young and middle-aged women with hypertension].
Topics: Adolescent; Adult; Antihypertensive Agents; Biphenyl Compounds; Felodipine; Female; Humans; Hyperten | 2010 |
Effect of atenolol vs metoprolol succinate on vascular function in patients with hypertension.
Topics: Adrenergic beta-1 Receptor Antagonists; Antihypertensive Agents; Atenolol; Blood Pressure; Boston; C | 2011 |
β(1)-adrenergic receptor polymorphisms and response to β-blockade in the African-American study of kidney disease and hypertension (AASK).
Topics: Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; Female; Genotype; Humans; Hypertension; Ma | 2011 |
The effect of metoprolol alone and combined metoprolol-felodipin on the digital microcirculation of patients with primary Raynaud's syndrome.
Topics: Adult; Drug Therapy, Combination; Felodipine; Female; Fingers; Humans; Hyperemia; Hypertension; Lase | 2011 |
Differential effects of nebivolol and metoprolol on central aortic pressure and left ventricular wall thickness.
Topics: Adult; Aged; Antihypertensive Agents; Aorta; Benzopyrans; Blood Pressure; Carotid Arteries; Double-B | 2011 |
Limitations of analyses based on achieved blood pressure: lessons from the African American study of kidney disease and hypertension trial.
Topics: Adult; Aged; Amlodipine; Antihypertensive Agents; Black or African American; Blood Pressure; Female; | 2011 |
β-Blockers in patients with intermittent claudication and arterial hypertension: results from the nebivolol or metoprolol in arterial occlusive disease trial.
Topics: Adrenergic beta-Antagonists; Ankle Brachial Index; Antihypertensive Agents; Arterial Occlusive Disea | 2011 |
[Effect of different combined antihypertensive regimen on the erectile function in male hypertensive patients].
Topics: Adult; Antihypertensive Agents; Biphenyl Compounds; Drug Therapy, Combination; Erectile Dysfunction; | 2011 |
Effect of felodipine with irbesartan or metoprolol on sexual function and oxidative stress in women with essential hypertension.
Topics: Adolescent; Adult; Antihypertensive Agents; Biphenyl Compounds; Felodipine; Female; Humans; Hyperten | 2012 |
A controlled study on the antihypertensive effect of a new beta-adrenergic receptor blocking drug, metoprolol, in combination with chlorthalidone.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Chlorthalidone; Cross-Over Studie | 1976 |
The effect of metoprolol and practolol on lung function and blood pressure in hypertensive asthmatics.
Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Aged; Blood Pressure; Cross-Over Studies; Double-Blin | 1976 |
Effect of fixed dose combinations of metoprolol and amlodipine in essential hypertension: MARS--a randomized controlled trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amlodipine; Blood Pressure; Dose-Response Relationship, | 2011 |
The impact of carvedilol and metoprolol on serum lipid concentrations and symptoms in patients with hyperthyroidism.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; Carbazoles; Carvedilol; Heart | 2012 |
Nebivolol and metoprolol: long-term effects on inflammation and oxidative stress in essential hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Benzopyrans; Blood Glucose; Cholesterol; Double-Blind Method; | 2012 |
[Advantages of quinapril therapy in patients with arterial hypertension and functional class III chronic heart failure with preserved left ventricular ejection fraction].
Topics: Antihypertensive Agents; Biological Availability; Blood Pressure; Drug Monitoring; Female; Heart Fai | 2012 |
Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: results from the AASK trial.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Anti | 2002 |
Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: results from the AASK trial.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Anti | 2002 |
Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: results from the AASK trial.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Anti | 2002 |
Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: results from the AASK trial.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Anti | 2002 |
Improvement of insulin sensitivity by a long-acting nifedipine preparation (nifedipine-CR) in patients with essential hypertension.
Topics: Adrenergic beta-Antagonists; Aged; Area Under Curve; Blood Glucose; Calcium Channel Blockers; Delaye | 2002 |
[Pharmacological modulation of NO synthesis in patients with arterial hypertension and endothelial dysfunction].
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Benzopyrans; Endothelium, Vascular; Ethanolami | 2003 |
[Efficacy and safety of different beta-blockers in patients with isolated systolic hypertension associated with diabetes mellitus and obstructive pulmonary diseases].
Topics: Adrenergic beta-Antagonists; Atenolol; Bisoprolol; Blood Pressure; Blood Pressure Monitoring, Ambula | 2003 |
Reduction (TELMAR) as assessed by magnetic resonance imaging in patients with mild-to-moderate hypertension--a prospective, randomised, double-blind comparison of telmisartan with metoprolol over a period of six months rationale and study design.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers | 2003 |
Effect of low-dose metoprolol in combination with sibutramine therapy in normotensive obese patients: a randomized controlled study.
Topics: Adrenergic beta-Antagonists; Adult; Anthropometry; Appetite Depressants; Arrhythmias, Cardiac; Cyclo | 2004 |
[Assessment of the efficacy and tolerance of delayed-action nifedipine as the monotherapy or in combination with metoprolol in patients with arterial hypertension].
Topics: Blood Pressure; Blood Pressure Monitoring, Ambulatory; Cross-Over Studies; Delayed-Action Preparatio | 2003 |
Effects of moxonidine vs. metoprolol on blood pressure and metabolic control in hypertensive subjects with type 2 diabetes.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Diabetes Mellitus, Type 2; Diabetic Angiopathi | 2004 |
Nonlinear mixed effects model analysis of the pharmacokinetics of metoprolol in routinely treated Japanese patients.
Topics: Age Factors; Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; Asian People; Cytochrome P-450 | 2004 |
Metabolic effects of carvedilol vs metoprolol in patients with type 2 diabetes mellitus and hypertension: a randomized controlled trial.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitor | 2004 |
Current concepts of pharmacotherapy in hypertension. Carvedilol: new considerations for its use in the diabetic patient with hypertension.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Antihypertensive Agents; Blood Glucose; C | 2005 |
Regression of carotid atherosclerosis by control of morning blood pressure peak in newly diagnosed hypertensive patients.
Topics: Adult; Antihypertensive Agents; Blood Pressure Monitoring, Ambulatory; Carbazoles; Carotid Artery Di | 2005 |
The relationship between magnitude of proteinuria reduction and risk of end-stage renal disease: results of the African American study of kidney disease and hypertension.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Blac | 2005 |
Blood pressure control, drug therapy, and kidney disease.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Anti | 2005 |
[Effects of ACE inhibitor fosinopril on a 24-h profile of arterial pressure in hypertensive patients with obesity and hypercholesterolemia].
Topics: Adrenergic beta-Antagonists; Adult; Angiotensin-Converting Enzyme Inhibitors; Drug Administration Sc | 2005 |
Favourable long term prognosis in stable angina pectoris: an extended follow up of the angina prognosis study in Stockholm (APSIS).
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Calcium Channel Blockers; Death, Sudden, Cardiac; Diab | 2006 |
Beta blocker effects on plasma homocysteine levels in patients with hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; Female; Homocysteine; Humans; Hyperhomocys | 2005 |
Impact of CYP2D6 genotype on adverse effects during treatment with metoprolol: a prospective clinical study.
Topics: Adrenergic beta-1 Receptor Antagonists; Cytochrome P-450 CYP2D6; Dose-Response Relationship, Drug; F | 2005 |
Felodipine-metoprolol combination tablet: maintained health-related quality of life in the presence of substantial blood pressure reduction.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Calcium Channel B | 2005 |
Early initiation of beta blockade in heart failure: issues and evidence.
Topics: Adrenergic beta-Antagonists; Carbazoles; Carvedilol; Heart Failure; Humans; Hypertension; Metoprolol | 2005 |
Influence of chronic renal failure on stereoselective metoprolol metabolism in hypertensive patients.
Topics: Adrenergic beta-Antagonists; Adult; Antihypertensive Agents; Cytochrome P-450 CYP2D6; Debrisoquin; F | 2005 |
[Antihypertensive activity and effect on parameters of heart rate variability of beta-blockers carvedilol and metoprolol].
Topics: Adrenergic beta-Antagonists; Carbazoles; Carvedilol; Female; Heart Rate; Humans; Hypertension; Male; | 2005 |
Comparative effects of nebivolol and metoprolol on oxidative stress, insulin resistance, plasma adiponectin and soluble P-selectin levels in hypertensive patients.
Topics: Adiponectin; Adult; Antihypertensive Agents; Benzopyrans; Ethanolamines; Female; Humans; Hypertensio | 2006 |
A factorial study of combination hypertension treatment with metoprolol succinate extended release and felodipine extended release results of the Metoprolol Succinate-Felodipine Antihypertension Combination Trial (M-FACT).
Topics: Administration, Oral; Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Antih | 2006 |
The effect of extended-release metoprolol succinate on C-reactive protein levels in persons with hypertension.
Topics: Adrenergic beta-Antagonists; Adult; C-Reactive Protein; Delayed-Action Preparations; Female; Humans; | 2006 |
Quality of life in the African American Study of Kidney Disease and Hypertension: effects of blood pressure management.
Topics: Adolescent; Adult; Aged; Amlodipine; Antihypertensive Agents; Black or African American; Blood Press | 2006 |
beta1-Adrenergic receptor polymorphisms influence the response to metoprolol monotherapy in patients with essential hypertension.
Topics: Adrenergic beta-Antagonists; Blood Pressure; China; Female; Humans; Hypertension; Male; Metoprolol; | 2006 |
Effects of nebivolol on platelet activation in hypertensive patients: a comparative study with metoprolol.
Topics: Antihypertensive Agents; Benzopyrans; Blood Platelets; Double-Blind Method; Ethanolamines; Female; H | 2007 |
Discordant beta-blocker effects on clinic, ambulatory, resting, and exercise hemodynamics in patients with hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Ambulatory Care Facilities; Antihypertensive Agents; Blood | 2006 |
A comparison of the trough-to-peak ratio of cardio-selective beta-blockers in patients with newly diagnosed hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Betaxolol; Blood Pressure; Blood Pressure Monitoring, Ambulatory | 2006 |
Factorial antihypertensive study of an extended-release metoprolol and hydrochlorothiazide combination.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Bl | 2006 |
Efficacy and safety of extended release metoprolol succinate in hypertensive children 6 to 16 years of age: a clinical trial experience.
Topics: Administration, Oral; Adolescent; Adrenergic beta-Antagonists; Analysis of Variance; Blood Pressure | 2007 |
Efficacy and safety of extended release metoprolol succinate in hypertensive children 6 to 16 years of age: a clinical trial experience.
Topics: Administration, Oral; Adolescent; Adrenergic beta-Antagonists; Analysis of Variance; Blood Pressure | 2007 |
Efficacy and safety of extended release metoprolol succinate in hypertensive children 6 to 16 years of age: a clinical trial experience.
Topics: Administration, Oral; Adolescent; Adrenergic beta-Antagonists; Analysis of Variance; Blood Pressure | 2007 |
Efficacy and safety of extended release metoprolol succinate in hypertensive children 6 to 16 years of age: a clinical trial experience.
Topics: Administration, Oral; Adolescent; Adrenergic beta-Antagonists; Analysis of Variance; Blood Pressure | 2007 |
Nitric oxide, erectile dysfunction and beta-blocker treatment (MR NOED study): benefit of nebivolol versus metoprolol in hypertensive men.
Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Antihypertensive Agents; Benzopyrans; Blood Pressure; | 2007 |
Effect of antihypertensive agents on plasma adiponectin levels in hypertensive patients with metabolic syndrome.
Topics: Adiponectin; Adrenergic beta-Antagonists; Adult; Amlodipine; Angiotensin II Type 1 Receptor Blockers | 2007 |
beta-blocker use and diabetes symptom score: results from the GEMINI study.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Carbazoles; Carvedilol; Cognition; Diab | 2007 |
Optimal treatment of obesity-related hypertension: the Hypertension-Obesity-Sibutramine (HOS) study.
Topics: Adult; Aged; Antihypertensive Agents; Appetite Depressants; Blood Pressure; Body Weight; Cyclobutane | 2007 |
Differential effect of beta-blocker therapy on insulin resistance as a function of insulin sensitizer use: results from GEMINI.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Blood Glucose; Carbazoles; Carvedilol; Diabete | 2007 |
Comparative clinical study of the efficacy and safety of a S-metoprolol ER tablet versus a racemate metoprolol ER tablet in patients with chronic stable angina.
Topics: Adrenergic beta-Antagonists; Aged; Analysis of Variance; Angina Pectoris; Blood Pressure; Chronic Di | 2007 |
Effects of carvedilol versus metoprolol on endothelial function and oxidative stress in patients with type 2 diabetes mellitus.
Topics: Aged; Antihypertensive Agents; Carbazoles; Carvedilol; Diabetes Mellitus, Type 2; Double-Blind Metho | 2007 |
Body weight changes with beta-blocker use: results from GEMINI.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Body Weight; C | 2007 |
Lowering blood pressure with beta-blockers in combination with other renin-angiotensin system blockers in patients with hypertension and type 2 diabetes: results from the GEMINI Trial.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitor | 2007 |
Renal and cardiac effects of antihypertensive treatment with ramipril vs metoprolol in autosomal dominant polycystic kidney disease.
Topics: Adrenergic beta-Antagonists; Adult; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agent | 2008 |
Effect of nebivolol and metoprolol treatments on serum asymmetric dimethylarginine levels in hypertensive patients with type 2 diabetes mellitus.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Adult; Aged; Arginine; Benzopyrans; Biomarkers; B | 2007 |
[Efficacy, safety and tolerance of Felodipine controlled release tablets and Felodipine controlled release tablets associated combination therapy in the treatment of mild to moderate essential hypertension in China].
Topics: Adult; Aged; Antihypertensive Agents; China; Delayed-Action Preparations; Drug Therapy, Combination; | 2007 |
A randomized, double-blind study of valsartan versus metoprolol on arterial distensibility and endothelial function in essential hypertension.
Topics: Adult; Antihypertensive Agents; Blood Flow Velocity; Blood Pressure; Brachial Artery; Carotid Arteri | 2008 |
Comparative efficacy of two different beta-blockers on 24-hour blood pressure control.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Blood Pressure; Blood Pressure Monitoring, Ambul | 2008 |
[Effect of antihypertensive agents from various pharmacological groups on blood pressure reaction during stress-testing. Part I. Comparative characteristics of medications, exerting effect of sympathoadrenal block].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Carbazoles; Carve | 2008 |
Comparison of rate and rhythm control in hypertension patients with atrial fibrillation.
Topics: Adrenergic beta-Antagonists; Aged; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting E | 2008 |
The comparative effects of metoprolol and perindopril on aortic elasticity in young patients with prehypertension.
Topics: Adult; Antihypertensive Agents; Aorta; Elasticity; Female; Humans; Hypertension; Male; Metoprolol; M | 2008 |
[The effects of furosemide on beta-blocker-induced hemodynamic changes in patients with hypertension (author's transl)].
Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Cardiac Output; Furosemide; Hemodynamics; Humans | 1980 |
Seven years on a selective beta-blocker - metoprolol. A long-term study of women with arterial hypertension.
Topics: Adrenergic beta-Antagonists; Alprenolol; Clinical Trials as Topic; Drug Therapy, Combination; Female | 1981 |
[Control of hypertension and blood lactate during exercise. Comparison of central antihypertensive agents with the cardio-selective beta blockers metoprolol and atenolol].
Topics: Adrenergic beta-Antagonists; Adult; Atenolol; Female; Humans; Hypertension; Lactates; Male; Metoprol | 1981 |
Comparative study of atenolol, metoprolol, metoprolol durules, and slow-release oxprenolol in essential hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Atenolol; Blood Pressure; Clinical Trials as Topic; Delayed-Acti | 1981 |
Influence of beta-blocking drugs on glucose metabolism in patients with non-insulin dependent diabetes mellitus.
Topics: Adrenergic beta-Antagonists; Aged; Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus; Doubl | 1982 |
Adrenergic mechanisms in control of plasma lipid concentrations.
Topics: Adrenergic beta-Antagonists; Atenolol; Cholesterol; Cholesterol, HDL; Clinical Trials as Topic; Fatt | 1982 |
The influence of beta-adrenoceptor blockade on left ventricular function.
Topics: Adrenergic beta-Antagonists; Cardiac Output; Heart; Heart Failure; Humans; Hypertension; Metoprolol; | 1982 |
beta-Blockers and myocardial infarction.
Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Clinical Trials as Topic; Death, Sudden; Diuretic | 1982 |
Labetalol, beta blockers, and acute deterioration of chronic airway obstruction.
Topics: Adrenergic beta-Antagonists; Aged; Atenolol; Ethanolamines; Humans; Hypertension; Labetalol; Lung Di | 1982 |
Effect of long-term beta-adrenergic-blockade on calf blood flow in hypertensive patients.
Topics: Adrenergic beta-Antagonists; Aged; Ankle; Arm; Blood Pressure; Female; Hemodynamics; Humans; Hyperte | 1983 |
A comparison of two cardioselective beta-blockers with different ancillary properties in the treatment of hypertension.
Topics: Acebutolol; Adrenergic beta-Antagonists; Adult; Clinical Trials as Topic; Double-Blind Method; Femal | 1982 |
beta-adrenoceptor blockade and physical activity: cardiovascular and metabolic aspects.
Topics: Acebutolol; Adrenergic beta-Antagonists; Adult; Blood Glucose; Catecholamines; Hemodynamics; Humans; | 1983 |
Prorenin and beta-blockade in hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Clinical Trials as Topic; Enzyme Precursors; Humans; Hyper | 1983 |
Propranolol vs metoprolol vs labetalol: a comparative study in essential hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Double-Blind Method; Female; Humans; Hypertensio | 1984 |
Neonatal effects of beta-blocking drugs in pregnancy.
Topics: Adrenergic beta-Antagonists; Apgar Score; Birth Weight; Carbon Dioxide; Cephalometry; Clinical Trial | 1984 |
The use of beta-adrenergic blocking drugs in patients with myocardial infarction.
Topics: Adrenergic beta-Antagonists; Alprenolol; Angina Pectoris; Atenolol; Clinical Trials as Topic; Humans | 1984 |
Single-agent and combination therapy of essential hypertension.
Topics: Acebutolol; Adrenergic beta-Antagonists; Adult; Aldosterone; Blood Pressure; Diuretics; Drug Therapy | 1984 |
Physical performance and muscle metabolism during beta-adrenergic blockade in man.
Topics: Adrenergic beta-Antagonists; Adult; Atenolol; Blood Pressure; Clinical Trials as Topic; Energy Metab | 1984 |
Haemodynamic effects of noise exposure before and after beta 1-selective and non-selective beta-adrenoceptor blockade in patients with essential hypertension.
Topics: Adult; Hemodynamics; Humans; Hypertension; Male; Metoprolol; Middle Aged; Noise; Propanolamines; Pro | 1981 |
Influence of beta-blocking drugs on glucose metabolism in hypertensive, non-diabetic patients.
Topics: Adult; Aged; Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus; Double-Blind Method; Fatty | 1983 |
A comparison of once daily atenolol and metoprolol SA in mild to moderate hypertension.
Topics: Adult; Aged; Atenolol; Blood Pressure; Clinical Trials as Topic; Delayed-Action Preparations; Double | 1983 |
Multiclinic comparison of labetalol to metoprolol in treatment of mild to moderate systemic hypertension.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Ethanolamines; Female; H | 1983 |
Influence of time and physical activity on blood pressure and heart rate during treatment with beta-blocking agents once daily.
Topics: Adult; Atenolol; Blood Pressure; Clinical Trials as Topic; Female; Heart Rate; Humans; Hypertension; | 1983 |
Comparison of the antihypertensive effect of a double dose of metoprolol versus the addition of hydrochlorothiazide to metoprolol.
Topics: Adult; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Female; Hea | 1983 |
A comparative trial of ordinary metoprolol tablets and metoprolol sustained-release tablets in hypertensive patients at rest and on exercise.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Delayed-Action Preparations; Female; Humans; | 1984 |
Atenolol 50 mg or metoprolol 200 mg - a comparison of antihypertensive efficacy, side effects and lipoprotein changes.
Topics: Adult; Atenolol; Blood Pressure; Clinical Trials as Topic; Fatigue; Female; Heart Rate; Humans; Hype | 1983 |
The effects of acute or chronic ingestion of propranolol or metoprolol on the metabolic and hormonal responses to prolonged, submaximal exercise in hypertensive men.
Topics: Blood Glucose; Catecholamines; Fatty Acids, Nonesterified; Glycerol; Growth Hormone; Humans; Hydroco | 1984 |
Chronic effects of metoprolol and methyldopa on calf blood flow in intermittent claudication.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Female; Heart Rate; Huma | 1984 |
A study of efficacy, tolerance and compliance of once-daily versus twice-daily metoprolol (Betaloc) in hypertension. Betaloc Compliance Canadian Cooperative Study Group.
Topics: Clinical Trials as Topic; Delayed-Action Preparations; Female; Humans; Hypertension; Male; Metoprolo | 1984 |
Walking capacity of patients with intermittent claudication during chronic antihypertensive treatment with metoprolol and methyldopa.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Exercise Test; Female; H | 1984 |
A placebo controlled trial of metoprolol in the treatment of hypertension in pregnancy.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Embryonic and Fetal Development; Female; Human | 1984 |
A comparison of 100 mg atenolol and 100 mg metoprolol once a day at rest and during exercise in hypertensives.
Topics: Adult; Atenolol; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Exercise Test; Heart | 1984 |
[Effectiveness of metoprolol (Betaloc-Astra) in the ambulatory treatment of hypertension].
Topics: Ambulatory Care; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Female; Humans; | 1984 |
New drugs: beta blockers and sympathomimetics.
Topics: Atenolol; Clinical Trials as Topic; Humans; Hypertension; Metoprolol; Propanolamines; Sleep | 1983 |
Comparison of thiazides and amiloride in treatment of moderate hypertension.
Topics: Adult; Aged; Amiloride; Drug Combinations; Drug Therapy, Combination; Humans; Hydrochlorothiazide; H | 1983 |
Effect on intra-arterial blood pressure of slow release metoprolol combined with placebo or chlorthalidone.
Topics: Adult; Aged; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Delayed-Action Preparations; | 1983 |
Beta blockade, diuretics, and salt restriction for the management of mild hypertension: a randomised double blind trial.
Topics: Adult; Aged; Chlorthalidone; Clinical Trials as Topic; Diet, Sodium-Restricted; Double-Blind Method; | 1984 |
On the combination of alpha- and beta-adrenoceptor blockade in hypertension.
Topics: Adult; Double-Blind Method; Drug Evaluation; Drug Therapy, Combination; Ethanolamines; Female; Human | 1983 |
A comparison between atenolol and metoprolol in respect of central nervous system side effects.
Topics: Atenolol; Central Nervous System Diseases; Double-Blind Method; Humans; Hypertension; Metoprolol | 1983 |
Heart rate and QT interval in subjects adapted to beta-blockade: bradycardia and hypotension as uncorrelated adaptations.
Topics: Adaptation, Physiological; Adult; Aged; Blood Pressure; Electrocardiography; Heart Rate; Humans; Hyp | 1983 |
Long acting beta-blockers in the twenty fourth hour.
Topics: Blood Glucose; Blood Pressure; Delayed-Action Preparations; Drug Evaluation; Electrocardiography; Ex | 1983 |
The effects of acute or chronic ingestion of propranolol or metoprolol on the physiological responses to prolonged, submaximal exercise in hypertensive men.
Topics: Adult; Aged; Blood Pressure; Emotions; Heart Rate; Humans; Hypertension; Male; Metoprolol; Middle Ag | 1984 |
Göteborg Metoprolol Trial: design, patient characteristics and conduct.
Topics: Aged; Arrhythmias, Cardiac; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Electroca | 1984 |
Beta adrenoceptor antagonism and pressor response to phenylephrine.
Topics: Adult; Aged; Blood Pressure; Double-Blind Method; Drug Interactions; Female; Heart Rate; Humans; Hyp | 1984 |
Antihypertensive effects at rest and during exercise of a calcium blocker, nifedipine, alone and in combination with metoprolol.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Drug Synergism; Drug Therapy, Combination; He | 1982 |
[Comparative study of the combination of chlorthalidone with verapamil and metoprolol in arterial hypertension: evaluation by cycloergometrics].
Topics: Adult; Chlorthalidone; Clinical Trials as Topic; Drug Therapy, Combination; Exercise Test; Hemodynam | 1981 |
Metoprolol for hypertension. Open trial in general practice.
Topics: Age Factors; Aged; Clinical Trials as Topic; Drug Administration Schedule; Family Practice; Female; | 1982 |
A two year clinical evaluation of atenolol and metoprolol in the treatment of hypertension.
Topics: Adult; Atenolol; Clinical Trials as Topic; Heart Rate; Humans; Hypertension; Metoprolol; Middle Aged | 1982 |
Antihypertensive activity of once daily metoprolol alone and with chlorthalidone and comparison with a twice daily regimen.
Topics: Administration, Oral; Adolescent; Adult; Aged; Blood Pressure; Chlorthalidone; Clinical Trials as To | 1982 |
[Hypotensive effect of metoprolol].
Topics: Adult; Blood Pressure; Clinical Trials as Topic; Female; Humans; Hypertension; Male; Metoprolol; Mid | 1982 |
Comparison of sustained-release clonidine and long-acting propranolol in the treatment of hypertension.
Topics: Adult; Aged; Clinical Trials as Topic; Clonidine; Delayed-Action Preparations; Double-Blind Method; | 1982 |
Mode of action of beta-adrenoceptor blocking agents in hypertension. A comparison between metoprolol and pindolol with special reference to peripheral vascular effects.
Topics: Adult; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Extremities; Female; Heart Rat | 1982 |
[Atenolol and metoprolol in the treatment of slight to moderate hypertension. A comparative study].
Topics: Adult; Aged; Atenolol; Clinical Trials as Topic; Female; Humans; Hypertension; Male; Metoprolol; Mid | 1982 |
No effect of propranolol and metoprolol on tolbutamide-stimulated insulin-secretion in hypertensive diabetic and non-diabetic patients.
Topics: Clinical Trials as Topic; Diabetes Complications; Diabetes Mellitus; Double-Blind Method; Female; Hu | 1982 |
[Controlled study of the anti-hypertensive effects of indapamide, metoprolol and their combination in patients with essential arterial hypertension].
Topics: Adult; Aged; Aldosterone; Clinical Trials as Topic; Diuretics; Drug Therapy, Combination; Exercise T | 1982 |
[Protection of the hypertensive patient: comparative study of atenolol and metoprolol].
Topics: Adult; Atenolol; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Exercise Test; Femal | 1982 |
[Controlled study of antihypertensive effects of indapamide and metoprolol and their combination in patients with essential arterial hypertension].
Topics: Adult; Aged; Aldosterone; Clinical Trials as Topic; Diuretics; Drug Therapy, Combination; Female; He | 1982 |
Metoprolol in angina pectoris complicated by essential hypertension. A clinical comparison of the antianginal efficacy of metoprolol slow-release tablets (Durules) given once daily and propranolol tablets given twice daily.
Topics: Adult; Angina Pectoris; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; | 1981 |
Effects of short-term and long-term treatment with cardio-selective and non-selective beta-receptor blockade on carbohydrate and lipid metabolism and on plasma catecholamines at rest and during exercise.
Topics: Acebutolol; Adult; Blood Glucose; Dopamine; Epinephrine; Humans; Hypertension; Lipids; Long-Term Car | 1981 |
Atenolol and metoprolol once daily in hypertension.
Topics: Adult; Atenolol; Blood Pressure; Dose-Response Relationship, Drug; Drug Administration Schedule; Fem | 1982 |
Ambulatory blood pressure during once-daily randomised double-blind administration of atenolol, metoprolol, pindolol, and slow-release propranolol.
Topics: Adolescent; Adult; Aged; Atenolol; Blood Pressure; Clinical Trials as Topic; Delayed-Action Preparat | 1982 |
An evaluation of the effect on resting and exercise blood pressure of some first line treatments in hypertension.
Topics: Adult; Blood Pressure Determination; Drug Combinations; Exercise Test; Female; Humans; Hydrochloroth | 1983 |
Hemodynamic effects of isometric exercise and mental arithmetic in hypertension treated with selective and nonselective beta-blockade.
Topics: Adolescent; Adult; Blood Pressure; Epinephrine; Female; Forearm; Heart Rate; Humans; Hypertension; I | 1983 |
Plasma levels and effects of metoprolol after single and multiple oral doses.
Topics: Administration, Oral; Adult; Blood Pressure; Dose-Response Relationship, Drug; Female; Humans; Hyper | 1980 |
A new approach to drug trials in general practice. Comparison of the antihypertensive efficacy of metoprolol and atenolol.
Topics: Atenolol; Blood Pressure; Clinical Trials as Topic; Family Practice; Female; Heart Rate; Humans; Hyp | 1980 |
Clinical evaluation of the antihypertensive effect of metoprolol in combination with hydrochlorothiazide and hydralazine in an unselected hypertensive population.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Cholesterol; Clinical Trials as Topic; Drug Therapy, | 1980 |
Metoprolol and atenolol administered once daily in primary hypertension. A clinical comparison of the efficacy of two selective beta-adrenoceptor blocking agents.
Topics: Adult; Aged; Atenolol; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Meth | 1981 |
Circulatory effects of stress in essential hypertension.
Topics: Adult; Blood Pressure; Catecholamines; Clinical Trials as Topic; Cold Temperature; Double-Blind Meth | 1981 |
Sustained release metoprolol: a comparison with conventional formulation in the treatment of hypertension.
Topics: Blood Pressure; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Female; | 1981 |
Antihypertensive medication regimens and their revision. A General Practitioner Clinical Research Group study.
Topics: Aged; Clinical Trials as Topic; Double-Blind Method; Drug Administration Schedule; Female; Humans; H | 1981 |
["Slow-release" metoprolol in the therapy of hypertension: comparison with divided doses].
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Met | 1981 |
Long-acting beta-blockers in the twenty-fourth hour. A comparison in hypertension.
Topics: Adult; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Exercise Test; Fe | 1981 |
Metoprolol in high renin hypertension. A comparison with propranolol.
Topics: Adult; Clinical Trials as Topic; Female; Glomerular Filtration Rate; Humans; Hypertension; Hypertens | 1981 |
Metoprolol and propranolol in the treatment of essential hypertension - a long-term comparative study.
Topics: Adult; Aged; Clinical Trials as Topic; Female; Humans; Hypertension; Male; Metoprolol; Middle Aged; | 1981 |
Metoprolol administered once daily in the treatment of hypertension. A double-blind crossover comparison between conventional tablets and metoprolol Durules.
Topics: Adult; Blood Pressure; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; F | 1981 |
Comparative study of hydrochlorothiazide and a fixed combination of metoprolol and hydrochlorothiazide essential hypertension.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up S | 1981 |
Antihypertensive effect and tolerability of two fixed combination of metoprolol and hydrochlorothiazide followed by a long-term tolerance study with one combination.
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Drug Combinations; Female; Follow-Up Studies; Hum | 1981 |
A fixed combination of metoprolol and chlorthalidone in hypertension. A clinical trial in general practice.
Topics: Adult; Blood Pressure; Body Weight; Chlorthalidone; Clinical Trials as Topic; Drug Combinations; Fun | 1981 |
A double-blind crossover comparative study of the efficacy of single daily doses of conventional and slow-release metoprolol.
Topics: Adult; Aged; Blood Pressure; Body Weight; Clinical Trials as Topic; Delayed-Action Preparations; Dou | 1981 |
[Double-blind comparative study of the hypotensive effect of combination therapy with chlorthalidone and metoprolol or alpha-methyldopa].
Topics: Chlorthalidone; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Hu | 1981 |
[Verapamil-hydrochlorothiazide vs. metoprolol-hydrochlorothiazide. Trial in hypertensive patients].
Topics: Adult; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertensio | 1981 |
[Comparison of metroprolol and labetalol. Antihypertensive activity at rest and during exertion and effect on some noninvasive parameters of cardiovascular function].
Topics: Adult; Clinical Trials as Topic; Ethanolamines; Female; Hemodynamics; Humans; Hypertension; Labetalo | 1981 |
Once-daily metoprolol for hypertension.
Topics: Antihypertensive Agents; Clinical Trials as Topic; Double-Blind Method; Drug Administration Schedule | 1981 |
Metoprolol in hypertension: an open evaluation.
Topics: Adult; Aged; Blood Pressure; Bronchial Spasm; Clinical Trials as Topic; Depression; Diuretics; Drug | 1982 |
A trial of metoprolol in hypertensive insulin-dependent diabetic patients.
Topics: Adult; Aged; Benzothiadiazines; Clinical Trials as Topic; Diabetes Complications; Diabetes Mellitus; | 1982 |
Treatment of hypertension. Comparative trial of metoprolol Durules (once daily) and metoprolol tablets (twice daily).
Topics: Adult; Aged; Blood Pressure; Bronchial Spasm; Clinical Trials as Topic; Delayed-Action Preparations; | 1982 |
A double-blind comparison of spironolactone and hydrochlorothiazide in hypertensive patients treated with metoprolol.
Topics: Adult; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Fem | 1982 |
Antihypertensive effects of metoprolol and reserpine-hydrochlorothiazide.
Topics: Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Female; Humans; Hy | 1982 |
Pilot study of antihypertensive treatment in the elderly.
Topics: Aged; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Female; Humans; Hydrochlorot | 1982 |
Effect of metoprolol and alprenolol on the metabolic, hormonal, and haemodynamic response to insulin-induced hypoglycaemia in hypertensive, insulin-dependent diabetics.
Topics: Adult; Alprenolol; Diabetes Complications; Diabetes Mellitus; Female; Hemodynamics; Humans; Hyperten | 1982 |
Response of blood pressure and plasma norepinephrine to propranolol, metoprolol and clonidine during isometric and dynamic exercise in hypertensive patients.
Topics: Adult; Aged; Blood Pressure; Clonidine; Exercise Test; Female; Heart Rate; Humans; Hypertension; Iso | 1982 |
Once-daily penbutolol or atenolol can replace combination therapy in essential hypertension.
Topics: Atenolol; Blood Pressure; Chlorthalidone; Dose-Response Relationship, Drug; Drug Therapy, Combinatio | 1982 |
[Clinical, ergometric and polygraphic evaluation of the effects of metoprolol and labetalol administration in essential arterial hypertension. Comparative study].
Topics: Adult; Electrocardiography; Ethanolamines; Female; Humans; Hypertension; Labetalol; Male; Metoprolol | 1982 |
Selective and nonselective beta-adrenoceptor blockade in hypertension: responses to changes in posture, cold and exercise.
Topics: Blood Pressure; Cold Temperature; Dose-Response Relationship, Drug; Heart Rate; Humans; Hypertension | 1982 |
Effects of treatment with nifedipine and metoprolol in essential hypertension.
Topics: Adult; Double-Blind Method; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Hypertension | 1982 |
Comparison of withdrawal phenomena after propranolol, metoprolol, and pindolol.
Topics: Adult; Aged; Blood Pressure; Heart Rate; Humans; Hypertension; Isoproterenol; Metoprolol; Middle Age | 1982 |
Haemodynamic effects of metoprolol and pindolol: a comparison in hypertensive patients.
Topics: Adult; Blood Pressure; Double-Blind Method; Female; Hemodynamics; Humans; Hypertension; Male; Metopr | 1982 |
Effects of pindolol and metoprolol on plasma lipids and lipoproteins.
Topics: Adult; Aged; Blood Pressure; Female; Heart Rate; Hemodynamics; Humans; Hypertension; Lipids; Lipopro | 1982 |
A comparison of the effects of the slow release formulations of metoprolol and oxprenolol in hypertension.
Topics: Adult; Delayed-Action Preparations; Female; Heart Rate; Humans; Hypertension; Male; Metoprolol; Midd | 1982 |
[A comparative evaluation of metoprolol and methyldopa in hypertension therapy (author's transl)].
Topics: Adult; Aged; Blood Pressure; Female; Heart Rate; Humans; Hypertension; Male; Methyldopa; Metoprolol; | 1980 |
Metoprolol and pindolol in hypertension: different effects on peripheral haemodynamics.
Topics: Double-Blind Method; Female; Hemodynamics; Humans; Hypertension; Male; Metoprolol; Middle Aged; Pind | 1981 |
[Effects of metoprolol and a combination of metoprolol and hydrochlorothiazide on arterial tension values in hypertensive patients at rest and following exertion. Crossed double-blind study].
Topics: Adult; Aged; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; | 1981 |
A comparative study of atenolol and metoprolol in the treatment of hypertension.
Topics: Adult; Aged; Atenolol; Blood Pressure; Creatinine; Female; Heart Rate; Humans; Hypertension; Male; M | 1981 |
Sotalol and metoprolol comparison of their anti-hypertensive effect.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Female; Heart Rate; Humans; Hypertension; Male; Meto | 1981 |
A comparison between once-daily and twice-daily administration of metoprolol in the management of hypertension.
Topics: Adult; Blood Pressure; Drug Administration Schedule; Female; Humans; Hypertension; Male; Metoprolol; | 1980 |
Effects of diltiazem, metoprolol, enalapril and hydrochlorothiazide on frequency of ventricular premature complexes.
Topics: Analysis of Variance; Antihypertensive Agents; Cardiac Complexes, Premature; Diltiazem; Echocardiogr | 1994 |
Left ventricular and aortic root structure and function changes with beta blocker antihypertensive therapy. A one-year double blind study of celiprolol and metoprolol.
Topics: Aorta; Celiprolol; Double-Blind Method; Echocardiography, Doppler, Pulsed; Female; Hemodynamics; Hum | 1995 |
Effect of celiprolol and metoprolol on lipids, fibrinogen and airways function in hyperlipidaemic hypertensives: a randomised double-blind long-term parallel group trial.
Topics: Adult; Aged; Blood Pressure; Celiprolol; Double-Blind Method; Female; Fibrinogen; Heart Rate; Humans | 1995 |
Assessment of effects of two anti-hypertensive regimens on overall cardiovascular risk.
Topics: Adolescent; Adult; Aged; Blood Pressure; Cardiovascular Diseases; Cholesterol; Diuretics; Drug Thera | 1995 |
Effect of beta-blockade on exercise capacity in hypertensive subjects: a one-year double-blind study of celiprolol and metoprolol.
Topics: Adult; Aged; Blood Pressure; Body Mass Index; Celiprolol; Double-Blind Method; Echocardiography; Ele | 1995 |
Metoprolol minimizes nighttime blood pressure dip in hypertensive black males.
Topics: Adult; Black People; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Circadian Rhythm; Humans | 1995 |
The effects of tertatolol on lipid profile.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Dihydralazine; Double-Blind Method; Drug Admin | 1993 |
Acute influence of beta-adrenergic antagonists on left ventricular diastolic function: contrasting results after administration of celiprolol and metoprolol.
Topics: Adrenergic beta-Antagonists; Adult; Celiprolol; Coronary Disease; Double-Blind Method; Heart; Humans | 1994 |
Extent of beta 1- and beta 2-receptor occupancy in plasma assesses the antagonist activity of metoprolol, pindolol, and propranolol in the elderly.
Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Animals; Double-Blind Method; Female; Humans; | 1993 |
Beneficial effects of beta-adrenergic blockade in coronary artery surgery: clinical research.
Topics: Acebutolol; Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; Cardiotonic Agents; Coronary A | 1993 |
Osmotic release oral drug delivery system of metoprolol in hypertensive asthmatic patients. Pharmacodynamic effects on beta 2-adrenergic receptors.
Topics: Administration, Inhalation; Adrenergic beta-Antagonists; Adult; Albuterol; Asthma; Atenolol; Double- | 1994 |
Effects of 100 mg of controlled-release metoprolol and 100 mg of atenolol on blood pressure, central nervous system-related symptoms, and general well being.
Topics: Adult; Atenolol; Blood Pressure; Central Nervous System; Delayed-Action Preparations; Double-Blind M | 1994 |
[The importance of studying the renin-angiotensin-aldosterone system in essential arterial hypertension in clinical practice. Activity of the renin-angiotensin-aldosterone system during treatment of hypertension with ACE-inhibitors and beta blockers].
Topics: Adult; Aldosterone; Cross-Over Studies; Enalapril; Female; Humans; Hypertension; Male; Metoprolol; M | 1994 |
Direct and indirect blood pressure in normotensive and hypertensive subjects.
Topics: Adult; Aged; Analysis of Variance; Blood Pressure; Blood Pressure Determination; Delayed-Action Prep | 1994 |
Nicardipine versus metoprolol in the treatment of hypertension during pregnancy: a randomized comparative trial.
Topics: Adult; Birth Weight; Blood Pressure; Cesarean Section; Drug Administration Schedule; Female; Humans; | 1994 |
Thermal biofeedback as an effective substitute for sympatholytic medication in moderate hypertension: a failure to replicate.
Topics: Biofeedback, Psychology; Blood Pressure; Diuretics; Female; Follow-Up Studies; Humans; Hypertension; | 1993 |
Metformin and metoprolol CR treatment in non-obese men.
Topics: Analysis of Variance; Anthropometry; Blood Pressure; Body Weight; Delayed-Action Preparations; Doubl | 1994 |
Treatment with a beta-blocker with beta 2-agonism improves glucose and lipid metabolism in essential hypertension.
Topics: Adult; Aged; Blood Glucose; Double-Blind Method; Female; Humans; Hypertension; Insulin; Labetalol; L | 1994 |
Antihypertensive efficacy and tolerability of a new once-daily felodipine-metoprolol combination compared with each component alone. The Swedish/UK Study Group.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Body Weight; Delayed-Action Preparations; Doub | 1993 |
Comparison of a felodipine-metoprolol combination tablet vs each component alone as antihypertensive therapy. The German Multicentre Study Group.
Topics: Adult; Aged; Blood Pressure; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Fe | 1993 |
Improved antihypertensive efficacy of the felodipine-metoprolol extended-release tablet compared with each drug alone.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Body Weight; Delayed-Action Preparations; Doub | 1993 |
[Vasoselective, substance-specific actions of isradipine on the great arteries of hypertensives in comparison to metoprolol].
Topics: Adult; Aged; Arteries; Blood Pressure; Double-Blind Method; Female; Heart Rate; Humans; Hypertension | 1994 |
Felodipine, metoprolol and their combination compared with placebo in isolated systolic hypertension in the elderly.
Topics: Aged; Aged, 80 and over; Blood Pressure; Double-Blind Method; Drug Combinations; Felodipine; Female; | 1994 |
Effect of lisinopril and metoprolol on arterial distensibility.
Topics: Adult; Blood Pressure; Carotid Artery, Common; Diastole; Double-Blind Method; Female; Humans; Hypert | 1994 |
Intrinsic effect of antihypertensive treatment with isradipine and metoprolol on large artery geometric and elastic properties.
Topics: Adult; Aged; Blood Pressure; Brachial Artery; Compliance; Double-Blind Method; Female; Heart Rate; H | 1993 |
A comparison of once-daily atenolol and metoprolol using office and ambulatory blood pressure monitoring.
Topics: Adolescent; Aged; Ambulatory Care; Atenolol; Blood Pressure; Blood Pressure Determination; Blood Pre | 1993 |
Forearm arterial distensibility in patients with hypertension: comparative effects of long-term ACE inhibition and beta-blocking.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Arteries; Compliance; Dipe | 1993 |
[Quality of life, adverse effects and effect on blood pressure of lisinopril and metoprolol in mild or moderate hypertension].
Topics: Adolescent; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Dipeptides; Double-Blind Method; | 1993 |
Obesity as a determinant for response to antihypertensive treatment.
Topics: Blood Pressure; Body Mass Index; Double-Blind Method; Humans; Hypertension; Isradipine; Male; Metopr | 1993 |
[The effect of captopril, metoprolol and hydrochlorothiazide therapy in patients with non-insulin-dependent diabetes (NIDDM) and primary hypertension. A double-blind, randomized cross-over study].
Topics: Aged; Captopril; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Evaluation; Female; Humans; Hy | 1993 |
A double-blind comparison of nicorandil and metoprolol in stable effort angina pectoris.
Topics: Adult; Angina Pectoris; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Method; Exerc | 1993 |
Plasma concentration-effect relationship of metoprolol during and after pregnancy.
Topics: Adult; Blood Pressure; Double-Blind Method; Female; Heart Rate; Humans; Hypertension; Metoprolol; Ph | 1993 |
Captopril or conventional therapy in hypertensive type II diabetics. Three-year analysis.
Topics: Aged; Albuminuria; Blood Pressure; Captopril; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Doub | 1993 |
[First dose response to cilazapril after discontinuation of metoprolol in hypertensive patients].
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Cilazapril; Dose-Response Relations | 1993 |
[The effect of hypotensive drugs on left ventricular mass and diastolic function].
Topics: Adult; Aged; Antihypertensive Agents; Calcium Channel Blockers; Diastole; Drug Therapy, Combination; | 1995 |
A double-blind comparison of once-daily metoprolol controlled-release and atenolol in the treatment of Chinese patients with mild to moderate hypertension.
Topics: Administration, Oral; Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; | 1995 |
Addition of urapidil or metoprolol to the treatment of hypertensive non-responders to nifedipine monotherapy: efficacy and metabolic effects. Italian Urapidil Study Group.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Cholesterol, HDL; Cholesterol, LDL; Drug Therapy, Co | 1995 |
Effects of felodipine, metoprolol and their combination on blood pressure at rest and during exercise and on volume regulatory hormones in hypertensive patients.
Topics: Adult; Aged; Aldosterone; Atrial Natriuretic Factor; Blood Pressure; Double-Blind Method; Drug Thera | 1995 |
Power spectral analysis of heart rate in elderly hypertensive subjects with or without silent coronary disease.
Topics: Aged; Algorithms; Amlodipine; Antihypertensive Agents; Case-Control Studies; Coronary Disease; Doubl | 1996 |
Effect of perindopril and metoprolol on left ventricular hypertrophy and performance in essential hypertension.
Topics: Adult; Antihypertensive Agents; Female; Hemodynamics; Humans; Hypertension; Hypertrophy, Left Ventri | 1995 |
Prostacyclin biosynthesis in essential hypertension before and during treatment.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aged; Amlodipine; Antihypertensive Agents; Bendroflumethiazide; | 1996 |
[Glycemia increases during treatment of hypertension. 13 years' experience in the treatment of middle-aged men, randomized for treatment with beta blockers and diuretics].
Topics: Adrenergic beta-Antagonists; Blood Glucose; Blood Pressure; Diuretics; Humans; Hydrochlorothiazide; | 1996 |
Decreased blood viscosity and serum levels of erythropoietin after anti-hypertensive treatment with amlodipine or metoprolol: results of a cross-over study.
Topics: Adult; Aged; Amlodipine; Blood Cell Count; Blood Chemical Analysis; Blood Viscosity; Cross-Over Stud | 1996 |
Relationship between sodium-lithium countertransport and insulin sensitivity in mild hypertension.
Topics: Antihypertensive Agents; Antiporters; Blood Glucose; Blood Pressure; Body Mass Index; Cross-Over Stu | 1996 |
Effects of losartan on insulin sensitivity in hypertensive subjects.
Topics: Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Double-Blind Method; Fatty Acids, Nones | 1996 |
Treatment of hypertension associated with stable angina pectoris: favourable interaction between new metoprolol formulation (OROS) and nifedipine.
Topics: Angina Pectoris; Antihypertensive Agents; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blo | 1996 |
Comparison of the hemodynamic effects of metoprolol and carvedilol in hypertensive patients.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Blood | 1996 |
Treatment and post-treatment effects of alpha- versus beta-receptor blockers on left ventricular structure and function in essential hypertension.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Double-Blind Method; Female; Heart | 1996 |
A comparison of the effect of enalapril and metoprolol on renal function, potassium balance, lipid profile, cardiac function, exercise tolerance and quality of life in hypertensive dialysis patients.
Topics: Adult; Anemia; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Cell Count; | 1995 |
[Combination antihypertensive therapy in patients with an increased risk profile].
Topics: Adult; Aged; Antihypertensive Agents; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide | 1996 |
The effect of metoprolol treatment on insulin sensitivity and diurnal plasma hormone levels in hypertensive subjects.
Topics: Adult; Blood Glucose; Blood Pressure; Circadian Rhythm; Cross-Over Studies; Double-Blind Method; Fem | 1997 |
Antihypertensive treatment with moexipril plus HCTZ vs metoprolol plus HCTZ in patients with mild-to-moderate hypertension.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; D | 1997 |
Nifedipine, captopril, metoprolol and nifedipine with metoprolol in hypertensive crisis in non-intensive care setting.
Topics: Acute Disease; Adolescent; Adult; Aged; Antihypertensive Agents; Blood Pressure; Captopril; Cost-Ben | 1996 |
Enalapril versus metoprolol in primary hypertension--effects on the glomerular filtration rate.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; | 1997 |
Hemodynamic differences between metoprolol and carvedilol in hypertensive patients.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Blood Pressure; Carbazoles; Cardiac Output; Ca | 1998 |
Vagal cardiac activity in essential hypertension: the effects of metoprolol and ramipril.
Topics: Adult; Antihypertensive Agents; Autonomic Nervous System; Baroreflex; Blood Pressure; Heart; Heart R | 1998 |
Blood pressure and aortic elastic properties--verapamil SR/trandolapril compared to a metoprolol/hydrochlorothiazide combination therapy.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive | 1998 |
Improved efficacy with maintained tolerability in the treatment of primary hypertension. Comparison between the felodipine-metoprolol combination tablet and monotherapy with enalapril. Swedish Multicentre Group.
Topics: Adrenergic beta-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Calcium | 1999 |
Response of serum total renin to ramipril and metoprolol in hypertensive patients.
Topics: Adrenergic beta-Antagonists; Adult; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Cross- | 1998 |
Comparison of effects of quinapril and metoprolol on glycaemic control, serum lipids, blood pressure, albuminuria and quality of life in non-insulin-dependent diabetes mellitus patients with hypertension. Swedish Quinapril Group.
Topics: Adrenergic beta-Antagonists; Aged; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Antihypert | 1998 |
Effects of combination antihypertensive therapy on baroreflex sensitivity and heart rate variability in systemic hypertension.
Topics: Aged; Antihypertensive Agents; Baroreflex; Blood Pressure; Double-Blind Method; Drug Therapy, Combin | 1999 |
Baroreflex sensitivity and the blood pressure response to beta-blockade.
Topics: Adolescent; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Barorefle | 1999 |
Combination therapy with felodipine and metoprolol compared with captopril and hydrochlorothiazide. German MC Study Group.
Topics: Antihypertensive Agents; Calcium Channel Blockers; Captopril; Double-Blind Method; Drug Therapy, Com | 1998 |
Ambulatory 24-h blood pressure assessment of the felodipine-metoprolol combination versus amlodipine in mild to moderate hypertension. Lorraine General Physician Investigators Group.
Topics: Amlodipine; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Drug The | 1999 |
Enantioselectivity in the steady-state pharmacokinetics of metoprolol in hypertensive patients.
Topics: Adult; Aged; Antihypertensive Agents; Area Under Curve; Debrisoquin; Female; Half-Life; Humans; Hype | 1999 |
[Effect of antihypertensive agents on plasma endothelin, nitric oxide and so on in essential hypertension].
Topics: Adrenergic beta-Antagonists; Adult; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agent | 1997 |
Felodipine-metoprolol combination tablet: a valuable option to initiate antihypertensive therapy?
Topics: Administration, Oral; Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Blood P | 1999 |
The effect of weight loss intervention on antihypertensive medication requirements in the hypertension Optimal Treatment (HOT) study.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Bloo | 1999 |
The pharmacodynamic and pharmacokinetic profiles of controlled-release formulations of felodipine and metoprolol in free and fixed combinations in elderly hypertensive patients.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Circadian Rhythm; Cross-Over Studies; Delayed-Action | 2000 |
Hypertension control improved through patient education. Chinese PEP Investigators.
Topics: Aged; Antihypertensive Agents; Female; Follow-Up Studies; Humans; Hypertension; Male; Metoprolol; Mi | 1998 |
Effect of ramipril vs amlodipine on renal outcomes in hypertensive nephrosclerosis: a randomized controlled trial.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Anti | 2001 |
Diabetics with hypertension not controlled with ACE inhibitors: alternate therapies.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitor | 2001 |
Effects of metoprolol CR/XL on mortality and hospitalizations in patients with heart failure and history of hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Double-Blind Method; Female; Heart Fail | 2002 |
[Prospects of use of the combined preparation logimax in patients with essential hypertension].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Calcium Channel Blockers; Delayed | 2002 |
[Effect of beta-blockers on the cardiac rhythm variability in patients with hypertension].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Heart Rate; Humans; Hypertension; | 2002 |
Long term non-selective and cardioselective beta-receptor blockade in hypertensive patients. Effects on circulatory parameters, catecholamines and renin activity under basal conditions and in connection with exercise and hypoglycemia.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aldosterone; Blood Glucose; Blood Pressure; Clinical Trial | 1976 |
Relative activity of atenolol and metoprolol.
Topics: Adrenergic beta-Antagonists; Atenolol; Exercise Test; Humans; Hypertension; Metoprolol; Propanolamin | 1977 |
The effect of mental arithmetic in normotensive and hypertensive subjects, and its modification by beta-adrenergic receptor blockade.
Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind M | 1977 |
A comparison between metoprolol and pindolol in the treatment of essential hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Body Weight; Drug Evaluation; Female; Heart Rate; Humans; Hypert | 1978 |
Metoprolol (Lopressor).
Topics: Adrenergic beta-Antagonists; Clinical Trials as Topic; Humans; Hypertension; Metoprolol; Propanolami | 1978 |
Abrupt withdrawal of beta-blocking agents in patients with arterial hypertension. Effect on blood pressure, heart rate and plasma catecholamines and prolactin.
Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Catecholamines; Clinical Trials as Topic; Female | 1979 |
A double-blind crossover comparison of pindolol, metoprolol, atenolol and labetalol in mild to moderate hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Clinical Trials as Topic; Double-Blind Method; E | 1979 |
Metoprolol or atenolol for mild-to-moderate hypertension.
Topics: Atenolol; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Humans; Hypertension; Metop | 1979 |
[Acute beta receptor blockade during the television transmission of the football world championship games 1978 in patients with a history of hypertension].
Topics: Humans; Hypertension; Metoprolol; Propanolamines; Psychomotor Agitation; Receptors, Adrenergic, beta | 1978 |
Effect of selective and non-selective beta-adrenoreceptor blockade on calf blood flow in hypertensive patients.
Topics: Blood Pressure; Heart Rate; Humans; Hypertension; Isoproterenol; Leg; Metoprolol; Propanolamines; Pr | 1978 |
South African multicentre study of metoprolol and propranolol in essential hypertension.
Topics: Clinical Trials as Topic; Female; Humans; Hypertension; Male; Metoprolol; Middle Aged; Propanolamine | 1977 |
Effects of adrenaline during treatment with propranolol and metoprolol.
Topics: Blood Pressure; Clinical Trials as Topic; Epinephrine; Humans; Hypertension; Metoprolol; Propanolami | 1977 |
Long term treatment of moderate hypertension with the beta1-receptor blocking agent metoprolol. II. Effect of submaximal work and insulin-induced hypoglycaemia on plasma catecholamines and renin activity, blood pressure and pulse rate.
Topics: Adult; Blood Pressure; Catecholamines; Clinical Trials as Topic; Epinephrine; Hemodynamics; Humans; | 1977 |
Long term treatment of moderate hypertension with the beta1-receptor blocking agent metoprolol. I. Effect on maximal working capacity, plasma catecholamines and renin, Urinary aldosterone, blood pressure and pulse rate under basal conditions.
Topics: Adult; Aldosterone; Blood Pressure; Catecholamines; Clinical Trials as Topic; Epinephrine; Hemodynam | 1977 |
[New selective beta 1-receptor antagonist. A comparison of metoprolol (Seloken) and placebo in mild to moderate hypertension].
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Female; Humans; Hyperte | 1977 |
Glucose tolerance and insulin release in hypertensive patients treated with the cardioselective beta-receptor blocking agent metoprolol.
Topics: Administration, Oral; Adult; Blood Glucose; Clinical Trials as Topic; Glucose; Glucose Tolerance Tes | 1977 |
Haemodynamic effects of adrenaline during treatment of hypertensive patients with propranolol and metoprolol.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Drug Interactions; Epinephrine; Hemodynamics; | 1977 |
Effect of insulin induced hypoglycaemia on the blood levels of catecholamines, glucagon, growth hormone, cortisol, C-peptide and proinsulin before and during medication with the cardioselective beta-receptor blocking agent metoprolol in man.
Topics: Adult; C-Peptide; Catecholamines; Clinical Trials as Topic; Glucagon; Growth Hormone; Half-Life; Hum | 1978 |
[Effect and concentration in plasma of metoprolol after administration in the morning and in the evening in essential hypertension].
Topics: Adult; Aged; Clinical Trials as Topic; Female; Humans; Hypertension; Male; Metoprolol; Middle Aged; | 1978 |
Beta-blockers: once or three times a day?
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Drug Administration Schedule; Female; Heart Fu | 1978 |
Results from a multicentre trial of metoprolol and a study of hypertensive patients with chronic obstructive lung disease.
Topics: Adult; Aged; Antihypertensive Agents; Asthma; Chronic Disease; Clinical Trials as Topic; Drug Therap | 1978 |
Antihypertensive activity of alpha-methyldopa on a twice daily regimen in comparison to metoprolol. A multi-centre controlled clinical trial.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Female; Heart Rate; Humans; Hypertension; Mal | 1978 |
Relative activity of atenolol and metoprolol.
Topics: Atenolol; Clinical Trials as Topic; Double-Blind Method; Humans; Hypertension; Metoprolol; Propanola | 1978 |
Atenolol and metoprolol in mild hypertension.
Topics: Atenolol; Clinical Trials as Topic; Double-Blind Method; Humans; Hypertension; Metoprolol; Propanola | 1978 |
Metoprolol with and without chlorthalidone in hypertension.
Topics: Adult; Blood Pressure; Body Weight; Chlorthalidone; Clinical Trials as Topic; Drug Therapy, Combinat | 1979 |
Beta-adrenergic blockade in stress protection. Limited effect of metoprolol in psychological stress reaction.
Topics: Adult; Attention; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Female; Heart Rate; | 1978 |
Effects of beta 1-selective and non-selective beta-blockade on blood pressure, plasma renin activity and plasma aldosterone in hypertensive patients.
Topics: Adult; Aldosterone; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; | 1979 |
Beta-adrenoceptor-blocking drugs and blood sugar control in diabetes mellitus.
Topics: Adult; Aged; Blood Glucose; Clinical Trials as Topic; Diabetes Complications; Diabetes Mellitus; Dou | 1979 |
Effects of propranolol and metoprolol on haemodynamic and respiratory indices and on perceived exertion during exercise in hypertensive patients.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Heart Rate; Hemodynamics; Humans; Hypertension | 1979 |
Once-daily metoprolol in primary hypertension.
Topics: Adult; Aldosterone; Blood Pressure; Clinical Trials as Topic; Drug Administration Schedule; Electrol | 1979 |
A controlled evaluation of metoprolol.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Hyperten | 1978 |
A comparison between metroprolol, alprenolol and oxprenolol in the treatment of hypertension.
Topics: Alprenolol; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Drug Ev | 1979 |
Antihypertensive effect of a non-selective (propranolol) and a cardioselective (metoprolol) beta-adrenoceptor blocking agent at rest and during exercise.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Exerc | 1979 |
Influence of metoprolol, alone and in combination with a thiazide diuretic, on blood pressure, plasma volume, extracellular volume and glomerular filtration rate in essential hypertension.
Topics: Adult; Benzothiadiazines; Blood Pressure; Body Weight; Clinical Trials as Topic; Diuretics; Drug The | 1979 |
Comparison of metoprolol and pindolol in the treatment of mild to moderate hypertension: a double-blind crossover study.
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Hypertension; Male; Meto | 1979 |
Double-blind comparison of metoprolol, alprenolol, and oxprenolol in hypertension.
Topics: Adult; Aged; Alprenolol; Blood Pressure; Clinical Trials as Topic; Dose-Response Relationship, Drug; | 1979 |
One year follow-up of hyperuricaemic hypertensive patients treated with tienilic acid or a diuretic with or without uric acid-lowering drugs.
Topics: Alkaline Phosphatase; Amiloride; Aspartate Aminotransferases; Bilirubin; Blood Pressure; Clinical Tr | 1979 |
[The influence of a long-term cardioselective and noncardioselective beta-receptorblockade on blood pressure, O2-uptake and carbohydrate metabolism. Ergometric investigations in hypertensive patients (author's transl)].
Topics: Blood Glucose; Blood Pressure; Carbohydrate Metabolism; Heart Rate; Humans; Hypertension; Lactates; | 1979 |
The effect of metoprolol on plasma lipids.
Topics: Adult; Aged; Cholesterol; Fatty Acids, Nonesterified; Female; Humans; Hypertension; Lipids; Male; Me | 1979 |
The effects of metoprolol on ambulatory blood pressure.
Topics: Adult; Blood Pressure; Circadian Rhythm; Heart Rate; Humans; Hypertension; Metoprolol; Middle Aged; | 1979 |
Effect of exercise in hypertension controlled with metoprolol or methyldopa.
Topics: Adult; Aged; Blood Pressure; Female; Heart Rate; Humans; Hypertension; Male; Methyldopa; Metoprolol; | 1979 |
Objective measurement of performance during acute stress in patients with essential hypertension: assessment of the effects of propranolol and metoprolol.
Topics: Adult; Automobile Driving; Blood Pressure; Female; Heart Rate; Humans; Hypertension; Male; Metoprolo | 1979 |
Effects of propranolol and metoprolol on the peripheral circulation.
Topics: Blood Flow Velocity; Blood Pressure; Depression, Chemical; Humans; Hypertension; Male; Metoprolol; M | 1978 |
[Hemodynamic changes in patients with arterial hypertension after beta-receptor blockade with propranolol and metoprolol (author's transl)].
Topics: Cardiac Catheterization; Heart Rate; Hemodynamics; Humans; Hypertension; Metoprolol; Propanolamines; | 1978 |
Comparison of metoprolol as hydrochlorothiazide and antihypertensive agents.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Body Weight; Clinical Trials as Topic; Female; Heart | 1976 |
Comparative study of metoprolol and alpha-methyldopa in untreated essential hypertension.
Topics: Blood Pressure; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Heart Rate; | 1976 |
Metoprolol in the long-term treatment of hypertension.
Topics: Adult; Aged; Alprenolol; Clinical Trials as Topic; Dose-Response Relationship, Drug; Female; Humans; | 1976 |
A controlled study on the anti-hypertensive effect of a new beta-adrenoreceptor-blocking drug, metoprolol, in combination with chlorthalidone.
Topics: Chlorthalidone; Clinical Trials as Topic; Drug Therapy, Combination; Heart Rate; Humans; Hypertensio | 1976 |
Effect of beta1-receptor blockade (Metoprolol, Selokenr) on blood pressure, pulse rate, plasma catecholamines, renin activity and urinary aldosterone.
Topics: Aldosterone; Blood Pressure; Catecholamines; Clinical Trials as Topic; Drug Evaluation; Humans; Hype | 1976 |
[Hemodynamic changes under metoprolol compared to propranolol in hypertensive patients].
Topics: Adult; Heart Rate; Humans; Hypertension; Metoprolol; Middle Aged; Propanolamines; Propranolol; Renin | 1976 |
Antihypertensive efficacy and side effects of three beta-blockers and a diuretic in elderly hypertensives: a report from the STOP-Hypertension study.
Topics: Aged; Aged, 80 and over; Amiloride; Atenolol; Double-Blind Method; Drug Therapy, Combination; Female | 1992 |
Comparison of the antihypertensive effects of carvedilol and metoprolol on resting and exercise blood pressure.
Topics: Adrenergic beta-Antagonists; Adult; Antihypertensive Agents; Blood Pressure; Carbazoles; Carvedilol; | 1992 |
The influence of different beta-blocking drugs on the peripheral circulation in Raynaud's phenomenon and in hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Blood Flow Velocity; Blood Pressure; Double-Blind Method; Female | 1992 |
Pharmacological modulation of stress-induced cardiovascular hyperreactivity in essential hypertension.
Topics: Calcium Channel Blockers; Dihydropyridines; Double-Blind Method; Hemodynamics; Humans; Hypertension; | 1992 |
Efficacy and tolerability of isradipine and metoprolol in treatment of hypertension: the Finnish Isradipine Study in Hypertension (FISH).
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Dihydropyridines; Double-Blind Method; Drug Th | 1992 |
Antihypertensive effect of felodipine associated with persistent sympathetic activation and minimal regression of left ventricular hypertrophy.
Topics: Adult; Aged; Analysis of Variance; Cardiomegaly; Double-Blind Method; Drug Therapy, Combination; Fel | 1992 |
Regression of left ventricular hypertrophy during long-term antihypertensive treatment--a comparison between felodipine and the combination of felodipine and metoprolol.
Topics: Adult; Analysis of Variance; Blood Pressure; Cardiomegaly; Double-Blind Method; Drug Therapy, Combin | 1992 |
Impact of antihypertensive therapy with isradipine and metoprolol on early markers of hypertensive nephropathy.
Topics: Antihypertensive Agents; Dihydropyridines; Double-Blind Method; Humans; Hypertension; Isradipine; Ki | 1992 |
Safety and efficacy of metoprolol in the treatment of hypertension in the elderly.
Topics: Age Factors; Aged; Blood Pressure; Clinical Protocols; Diastole; Drug Therapy, Combination; Female; | 1992 |
Placebo-controlled comparison of captopril, metoprolol, and hydrochlorothiazide therapy in non-insulin-dependent diabetic patients with primary hypertension.
Topics: Aged; Captopril; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Glomerular Filtration Rate; | 1992 |
[Exercise performance after long-term administration of enalapril or metoprolol. A randomized double-blind study of hypertensive leisure-time sportsmen].
Topics: Adult; Blood Pressure; Double-Blind Method; Enalapril; Exercise Test; Heart Rate; Humans; Hypertensi | 1992 |
Effectiveness of antihypertensive medications in office and ambulatory settings: a placebo-controlled comparison of atenolol, metoprolol, chlorthalidone, verapamil, and an atenolol-chlorthalidone combination.
Topics: Adult; Ambulatory Care; Antihypertensive Agents; Atenolol; Blood Pressure; Blood Pressure Determinat | 1992 |
Quality of life, side effects and efficacy of lisinopril compared with metoprolol in patients with mild to moderate essential hypertension.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Blood Pressure; Double-Blind Method; Enalapril; Fe | 1991 |
[Beta-blockers in the treatment of hypertension in elderly patients].
Topics: Adrenergic beta-Antagonists; Adult; Age Factors; Aged; Double-Blind Method; Female; Humans; Hyperten | 1991 |
Bopindolol: Czechoslovak experience with a new beta blocker in the treatment of hypertension.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Age Factors; Aged; Blood Glucose; Double-Blind Metho | 1991 |
Acute haemodynamic profile of celiprolol in patients with coronary heart disease and hypertension: a double-blind comparison with metoprolol.
Topics: Adrenergic beta-Antagonists; Adult; Celiprolol; Coronary Circulation; Coronary Disease; Double-Blind | 1991 |
Optimal felodipine dose when combined with metoprolol in arterial hypertension: a Swedish multicenter study within primary health care. Swedish General Practitioner Felodipine Study Group.
Topics: Adult; Aged; Blood Pressure; Body Weight; Delayed-Action Preparations; Double-Blind Method; Drug The | 1990 |
Comparison of felodipine with nifedipine as additions to metoprolol in the treatment of hypertension. U.K. Multicentre Hospital Group.
Topics: Adult; Aged; Blood Pressure; Double-Blind Method; Drug Therapy, Combination; Felodipine; Heart Rate; | 1990 |
Effect of metoprolol and pindolol monotherapy on plasma lipid- and lipoprotein-cholesterol levels (including the HDL subclasses) in mild hypertensive males and females.
Topics: Adult; Aged; Cholesterol; Cholesterol, HDL; Double-Blind Method; Female; Humans; Hypertension; Lipid | 1990 |
Antihypertensive efficacy and tolerability of a fixed combination of metoprolol and felodipine in comparison with the individual substances in monotherapy. The Swedish/United Kingdom Study Group.
Topics: Adult; Aged; Blood Pressure; Body Weight; Double-Blind Method; Drug Therapy, Combination; Electrocar | 1990 |
Influence of metoprolol and cilazapril on blood pressure and on sleep apnea activity.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Cilazapril; Double-Blind Meth | 1990 |
Coronary artery disease can be prevented by antihypertensive therapy: experiences from the MAPHY Study.
Topics: Adult; Antihypertensive Agents; Benzothiadiazines; Cerebrovascular Disorders; Coronary Disease; Deat | 1990 |
Sleep disturbances in hypertension: a double-blind study between isradipine and metoprolol.
Topics: Adult; Calcium Channel Blockers; Dihydropyridines; Double-Blind Method; Humans; Hypertension; Isradi | 1991 |
Regression of structural vascular changes after chronic treatment in hypertensives.
Topics: Acebutolol; Adult; Aged; Blood Pressure; Captopril; Female; Hemodynamics; Humans; Hypertension; Labe | 1991 |
Effect of antihypertensive drugs on insulin, glucose, and lipid metabolism.
Topics: Antihypertensive Agents; Atenolol; Blood Pressure; Captopril; Double-Blind Method; Glucose; Humans; | 1991 |
Influence of antihypertensive drug therapy on sleep pattern and sleep apnea activity.
Topics: Adult; Aged; Antihypertensive Agents; Cilazapril; Double-Blind Method; Electroencephalography; Human | 1991 |
Effects of chlorthalidone and metoprolol alone or in combination (logroton) on blood pressure, lipids, lipoproteins and circulating plasma ANF levels in essential hypertension.
Topics: Atrial Natriuretic Factor; Blood Pressure; Chlorthalidone; Cholesterol, HDL; Cholesterol, LDL; Chole | 1991 |
Effects of diltiazem and metoprolol on blood pressure, adverse symptoms and general well-being. The Swedish Diltiazem-Metoprolol Multi-Centre Study Group.
Topics: Adult; Aged; Blood Pressure; Diltiazem; Dose-Response Relationship, Drug; Female; Heart Rate; Humans | 1991 |
[Effect of metoprolol on microcirculation and blood viscoelasticity].
Topics: Blood Flow Velocity; Blood Viscosity; Humans; Hypertension; Metoprolol; Microcirculation; Middle Age | 1991 |
A pressor effect of noncardioselective beta blockers in mildly hypertensive patients during surgery under anesthesia.
Topics: Aged; Anesthesia, General; Blood Pressure; Female; Humans; Hypertension; Male; Metoprolol; Middle Ag | 1991 |
The use of carvedilol in elderly hypertensive patients.
Topics: Adrenergic beta-Antagonists; Adult; Age Factors; Aged; Aged, 80 and over; Blood Pressure; Carbazoles | 1990 |
[Comparison of the antihypertensive effects of bopindolol and metoprolol in the treatment of arterial hypertension].
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; Double-Blind Method; Female; H | 1990 |
Treatment of hypertension in the elderly: effects on blood pressure, heart rate, and physical fitness.
Topics: Aged; Amiloride; Antihypertensive Agents; Blood Pressure; Captopril; Female; Heart Rate; Hemodynamic | 1991 |
Metoprolol versus thiazide diuretics in hypertension. Morbidity results from the MAPHY Study.
Topics: Adult; Benzothiadiazines; Blood Pressure; Cardiovascular Diseases; Coronary Artery Bypass; Coronary | 1991 |
Primary prevention of sudden cardiovascular death in hypertensive patients. Mortality results from the MAPHY Study.
Topics: Adult; Arteriosclerosis; Bendroflumethiazide; Death, Sudden; Diuretics; Follow-Up Studies; Humans; H | 1991 |
Aspects of quality of life on treatment with felodipine.
Topics: Adult; Aged; Analysis of Variance; Dose-Response Relationship, Drug; Double-Blind Method; Drug Thera | 1991 |
Diltiazem compared with metoprolol as add-on-therapies to diuretics in hypertension. Swedish Diltiazem-Metoprolol Multicentre Study Group.
Topics: Aged; Blood Pressure; Diltiazem; Diuretics; Dose-Response Relationship, Drug; Double-Blind Method; D | 1991 |
A comparison of diltiazem and metoprolol in hypertension. Swedish Diltiazem-Metoprolol Multicentre Study Group.
Topics: Blood Pressure; Diltiazem; Double-Blind Method; Female; Heart Rate; Humans; Hypertension; Lipids; Ma | 1990 |
The interaction of alcohol and beta-blockers in arterial hypertension.
Topics: Adult; Blood Pressure; Double-Blind Method; Ethanol; Heart Rate; Humans; Hypertension; Male; Metopro | 1990 |
Symptoms and well-being during antihypertensive treatment with thiazide diuretics.
Topics: Aged; Blood Pressure; Diuretics; Double-Blind Method; Female; Health Status; Humans; Hydrochlorothia | 1990 |
[Regression of left ventricular hypertrophy in hypertensive patients under long-term therapy with antihypertensive agents].
Topics: Acebutolol; Adult; Antihypertensive Agents; Atenolol; Cardiomegaly; Female; Gallopamil; Humans; Hype | 1990 |
A comparison of a controlled release (CR/ZOK) formulation of metoprolol, once daily, with conventional metoprolol tablets, twice daily, in mild to moderate hypertension.
Topics: Adult; Aged; Blood Pressure; Delayed-Action Preparations; Double-Blind Method; Female; Heart Rate; H | 1990 |
The efficacy of low dose metoprolol CR/ZOK in mild hypertension and in elderly patients with mild to moderate hypertension.
Topics: Adult; Aged; Blood Pressure; Delayed-Action Preparations; Double-Blind Method; Female; Heart Rate; H | 1990 |
A double-blind comparison of metoprolol CR/ZOK 50 mg and atenolol 50 mg once daily for uncomplicated hypertension.
Topics: Adolescent; Adult; Atenolol; Blood Pressure; Delayed-Action Preparations; Double-Blind Method; Exerc | 1990 |
Efficacy and tolerability of a fixed combination of metoprolol CR/ZOK 100 mg and hydrochlorothiazide (HCT) 12.5 mg in comparison with the fixed combination of metoprolol and HCT.
Topics: Adult; Aged; Blood Pressure; Delayed-Action Preparations; Double-Blind Method; Drug Therapy, Combina | 1990 |
Comparison of CNS-related subjective symptoms in hypertensive patients treated with either a new controlled release (CR/ZOK) formulation of metoprolol or atenolol.
Topics: Adolescent; Adult; Aged; Atenolol; Blood Pressure; Delayed-Action Preparations; Double-Blind Method; | 1990 |
Comparison of the antihypertensive efficiency of nitrendipine, metoprolol, mepindolol and enalapril using ambulatory 24-hour blood pressure monitoring.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Circadian Rhythm; Enalapril; Female; Humans; Hyperte | 1990 |
Effects of long-term treatment with metoprolol and hydrochlorothiazide on plasma lipids and lipoproteins.
Topics: Cholesterol; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Met | 1990 |
Antihypertensive drugs and glucose metabolism: comparison between a diuretic, a beta-blocker and felodipine, a new calcium antagonist in subjects with arterial hypertension and diabetes.
Topics: Aged; Blood Glucose; Diabetes Mellitus; Double-Blind Method; Felodipine; Female; Glucose Tolerance T | 1990 |
Cardiac function and cerebral blood flow in elderly hypertensive patients.
Topics: Aged; Cerebrovascular Circulation; Double-Blind Method; Enalapril; Female; Heart; Humans; Hypertensi | 1990 |
The effect of single-dose phenylpropanolamine on blood pressure in patients with hypertension controlled by beta blockers.
Topics: Adult; Atenolol; Blood Pressure; Double-Blind Method; Drug Administration Schedule; Humans; Hyperten | 1990 |
Thermoregulation in mildly hypertensive men during beta-adrenergic blockade.
Topics: Analysis of Variance; Body Temperature Regulation; Hemodynamics; Humans; Hypertension; Male; Metopro | 1990 |
Cardiac and skeletal muscle adaptations to training in systemic hypertension and effect of beta blockade (metoprolol or propranolol).
Topics: Adaptation, Physiological; Adult; Exercise Therapy; Female; Heart; Hemodynamics; Humans; Hypertensio | 1990 |
Comparative effects of diltiazem sustained-release formulation and metoprolol on ambulatory blood pressure and plasma lipoproteins.
Topics: Adult; Aged; Ambulatory Care; Blood Pressure; Delayed-Action Preparations; Diltiazem; Double-Blind M | 1990 |
Metabolic effects of controlled-release metoprolol in hypertensive men with impaired or diabetic glucose tolerance: a comparison with atenolol.
Topics: Aged; Atenolol; Blood Pressure; C-Peptide; Delayed-Action Preparations; Double-Blind Method; Glucose | 1990 |
The effect of captopril and metoprolol as monotherapy or combined with bendroflumethiazide on blood lipids.
Topics: Adult; Aged; Bendroflumethiazide; Body Weight; Captopril; Cholesterol; Cholesterol, HDL; Drug Therap | 1990 |
Long-acting nifedipine versus metoprolol as monotherapy for essential hypertension. A randomized, controlled crossover study.
Topics: Adult; Aged; Delayed-Action Preparations; Humans; Hypertension; Metoprolol; Middle Aged; Nifedipine; | 1990 |
Study with the competitive 5-HT2-serotonergic antagonist ketanserin.
Topics: Adult; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Heart Rate; Humans; Hypertensi | 1985 |
Effects of indoramin and metoprolol on plasma lipids and lipoproteins.
Topics: Adolescent; Adult; Aged; Apolipoprotein A-I; Apolipoproteins A; Apolipoproteins B; Cholesterol; Chol | 1986 |
Evaluation of antihypertensive efficacy of lisinopril compared to metoprolol in moderate to severe hypertension.
Topics: Age Factors; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Clinical Trials as Topic; Dou | 1987 |
Circadian antihypertensive profile of carvedilol (BM 14190).
Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Body Weight; Carbazoles; Carvedilol; Circadian R | 1987 |
Effect of carvedilol and metoprolol on blood pressure, blood flow, and vascular resistance.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Blood Flow Velocity; Blood Pressure; Carbazoles; Carvedilo | 1987 |
Comparative pharmacokinetics and antihypertensive effects of the nifedipine tablet and capsule.
Topics: Aged; Blood Pressure; Capsules; Double-Blind Method; Half-Life; Humans; Hypertension; Male; Metoprol | 1987 |
Treating hypertensive diabetics: a comparison of verapamil and metoprolol in black and white patients.
Topics: Albuminuria; Black People; Blood Glucose; Blood Pressure; Cholesterol; Diabetes Complications; Diabe | 1987 |
Slow-release metoprolol and nifedipine in essential hypertension: 24 hour noninvasive ambulatory blood pressure monitoring.
Topics: Adult; Ambulatory Care; Blood Pressure; Delayed-Action Preparations; Double-Blind Method; Female; Hu | 1987 |
Double-blind study on the interaction of oxaprozin with metoprolol in hypertensives.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Blood Pressure; Double-Blind Method | 1989 |
Sensitivity to insulin during treatment with atenolol and metoprolol: a randomised, double blind study of effects on carbohydrate and lipoprotein metabolism in hypertensive patients.
Topics: Atenolol; Blood Glucose; Cholesterol; Clinical Trials as Topic; Double-Blind Method; Female; Glucose | 1989 |
[24-hour blood pressure behavior in patients with untreated and treated hypertension in comparison with normotensive patients].
Topics: Adult; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitors; Circadian Rhythm; Drug Ther | 1989 |
[Regression of left heart hypertrophy in hypertensive patients as a result of antihypertensive therapy].
Topics: Acebutolol; Adult; Antihypertensive Agents; Atenolol; Cardiac Output; Cardiac Volume; Cardiomegaly; | 1989 |
Noradrenergic activity and silent ischaemia in hypertensive patients with stable angina: effect of metoprolol.
Topics: Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Coronary Disease; Double-Blind Method; El | 1989 |
Effects of dilevalol, metoprolol and atenolol on left ventricular mass and function in nonelderly and elderly hypertensive patients.
Topics: Adrenergic beta-Antagonists; Aged; Atenolol; Double-Blind Method; Echocardiography; Female; Heart; H | 1989 |
Influence of beta 2 agonism and beta 1 and beta 2 antagonism on adverse effects and plasma lipoproteins: results of a multicenter comparison of dilevalol and metoprolol.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aged; Cholesterol; Coronary Disease; Double-B | 1989 |
Responses of glomerular filtration, renal blood flow and salt-water handling to acute cardioselective and non-selective beta-adrenoceptor blockade in essential hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Glomerular Filtration Rate; Heart Rate; Hemodyna | 1989 |
Beta-blockers and diuretics. The HAPPHY and MAPHY studies.
Topics: Adrenergic beta-Antagonists; Arteriosclerosis; Benzothiadiazines; Cerebrovascular Disorders; Coronar | 1989 |
Confusing messages from the newest of the beta-blocker/diuretic hypertension trials. The Metoprolol Atherosclerosis Prevention in Hypertensives trial.
Topics: Adrenergic beta-Antagonists; Arteriosclerosis; Cardiovascular Diseases; Clinical Trials as Topic; Di | 1989 |
Regression of left ventricular hypertrophy in treated hypertensive patients with dilevalol and metoprolol--a double blind randomized study.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Cardiomegaly; Double-Blind Method; Echocardiography; Elect | 1989 |
Bopindolol in the treatment of hypertension: a double blind study comparing bopindolol and metoprolol.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Double-Blind Method; Drug Administration Schedule; Female; | 1989 |
[The effects of captopril and metoprolol on blood pressure and side effects in patients with mild to moderate hypertension].
Topics: Adult; Aged; Captopril; Clinical Trials as Topic; Female; Humans; Hypertension; Male; Metoprolol; Mi | 1989 |
Effects of beta blockade with metoprolol on simple and complex task performance.
Topics: Adult; Affect; Attention; Clinical Trials as Topic; Color Perception; Discrimination Learning; Doubl | 1989 |
Does hormone analysis predict the antihypertensive response of basic medical treatment?
Topics: Adolescent; Adult; Aldosterone; Clinical Trials as Topic; Dinoprost; Dinoprostone; Female; Humans; H | 1989 |
Ketanserin in the treatment of essential hypertension. A double blind trial against metoprolol followed by one-year open treatment.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Femal | 1989 |
Effects of long-term antihypertensive treatment on glucose metabolism.
Topics: Antihypertensive Agents; Atenolol; Blood Pressure; Clinical Trials as Topic; Diabetes Mellitus; Dilt | 1989 |
Antihypertensive efficacy and influence on physical activity of three different treatments in elderly hypertensive patients.
Topics: Aged; Amiloride; Antihypertensive Agents; Captopril; Drug Evaluation; Drug Therapy, Combination; Dru | 1989 |
[Effect of beta blockers with intrinsic sympathomimetic activity on blood pressure and blood lipids in patients with essential hypertension].
Topics: Aging; Blood Pressure; Clinical Trials as Topic; Exercise Test; Female; Heart Rate; Humans; Hyperten | 1989 |
Obesity and beta-blockers: influence of body fat on their kinetics and cardiovascular effects.
Topics: Adipose Tissue; Atenolol; Blood Pressure; Female; Heart Rate; Humans; Hypertension; Kinetics; Male; | 1989 |
Decreased coronary heart disease in hypertensive smokers. Mortality results from the MAPHY study.
Topics: Adult; Benzothiadiazines; Coronary Disease; Diuretics; Follow-Up Studies; Humans; Hypertension; Male | 1989 |
A comparison of enalapril and metoprolol as initial therapy for mild to moderate hypertension.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Enalapril; Humans; Hyper | 1987 |
[Ambulatory continuous 24-hour blood pressure monitoring in the diagnosis and therapy of arterial hypertension and modification by the antihypertensive agents enalapril, metoprolol, mepindolol and nitrendipine].
Topics: Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Circadian Rhythm; Clinical Tr | 1988 |
Combined beta 1-adrenoceptor blockade and/or beta 2- or beta 1/2 adrenoceptor stimulation as treatment of essential hypertension.
Topics: Adult; Blood Pressure; Drug Therapy, Combination; Female; Heart Rate; Humans; Hypertension; Male; Me | 1988 |
Acute hemodynamic effects of pinacidil and hydralazine in essential hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Cardiac Output; Double-Blind Method; Drug Evalua | 1985 |
Comparison of weight reduction with metoprolol in treatment of hypertension in young overweight patients.
Topics: Adult; Blood Pressure; Body Weight; Clinical Trials as Topic; Diet, Reducing; Double-Blind Method; F | 1985 |
Cardioselective and nonselective beta-adrenoceptor blocking drugs in hypertension: a comparison of their effect on blood pressure during mental and physical activity.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Bicycling; Blood Pressure; Female; H | 1985 |
Beta blockade and intermittent claudication.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Clinical Trials as Topic; Coronary Disease; Female; Gait; | 1985 |
Age and responses to isometric exercise in hypertension: possible predictors of the antihypertensive effect of diuretics and beta-blockers.
Topics: Adrenergic beta-Antagonists; Adult; Age Factors; Aged; Antihypertensive Agents; Blood Pressure; Chlo | 1985 |
Acute and long-term antihypertensive effect of bopindolol--a nonselective beta-adrenergic blocker with ISA.
Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Heart Rate; Humans; Hypertension; Male; Metoprol | 1985 |
Effects of alpha-adrenergic and beta-adrenergic receptor blockade on lipid metabolism.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Aged; Apolipoproteins | 1986 |
Renin and beta-blockade: prorenin and aldosterone may explain the controversy.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aldosterone; Blood Pressure; Clinical Trials as Topic; Dou | 1986 |
Blood pressure and catecholamines following exercise during selective beta-blockade in hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Catecholamines; Epinephrine; Female; Heart Rate; | 1986 |
Respiratory effects of four adrenergic blocking agents combined with a diuretic in treating hypertension with concurrent chronic obstructive lung disease.
Topics: Adrenergic beta-Antagonists; Airway Resistance; Atenolol; Chlorthalidone; Drug Therapy, Combination; | 1986 |
[Hemodynamic study, under hot and cold conditions, of the digital artery in arterial hypertension and the effects of cardioselective and non-cardioselective beta blocker treatment].
Topics: Adrenergic beta-Agonists; Adult; Arteries; Cold Temperature; Female; Fingers; Hemodynamics; Hot Temp | 1986 |
Metoprolol or hydrochlorothiazide in patients with hypertension aged 60-75 years. With special reference to assessment of compliance. Hunter Hypertension Research Group.
Topics: Aged; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Hydrochlorothia | 1986 |
Swedish trial in old patients with hypertension. A prospective multicentre study in Swedish primary health care.
Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Amiloride; Atenolol; Clinical Trials as Topic; | 1986 |
Comparative tolerability of labetalol versus propranolol, atenolol, pindolol, metoprolol, and nadolol.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Clinical Trials as Topic; Female; Humans; Hypert | 1986 |
Bopindolol versus metoprolol in hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Double-Blind Method; Humans; Hypertension; Metoprolol; Middle Ag | 1986 |
Responses to mental stress and physical provocations before and during long term treatment of hypertensive patients with beta-adrenoceptor blockers or hydrochlorothiazide.
Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Cyclic AMP; Epinephrine; Female; Glycerol; Heart | 1987 |
Effects of celiprolol on systemic and forearm circulation in hypertensive patients: a double-blind cross-over study versus metoprolol.
Topics: Adrenergic beta-Antagonists; Adult; Celiprolol; Double-Blind Method; Echocardiography; Female; Forea | 1987 |
Long-term antihypertensive therapy with beta-blockers: submaximal exercise capacity and metabolic effects during exercise.
Topics: Adrenergic beta-Antagonists; Adult; Electrocardiography; Energy Metabolism; Exercise Test; Female; H | 1987 |
Antihypertensive therapy with celiprolol: a new cardioselective beta blocker.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Atenolol; Celiprolol; Clinical Trials as Topic | 1988 |
Selective beta 1-adrenoceptor blockade and muscle thermogenesis.
Topics: Adrenergic beta-Antagonists; Body Temperature Regulation; Calorimetry; Catecholamines; Clinical Tria | 1988 |
Impact of beta-blockade on complex cognitive functioning.
Topics: Adrenergic beta-Antagonists; Adult; Affect; Atenolol; Blood Pressure; Clinical Trials as Topic; Cogn | 1988 |
Hypertension, exercise, and beta-adrenergic blockade.
Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Combined Modality Therapy; Double-Blind Method; | 1988 |
Critical comments on recent literature. SCRAAPHY about MAPHY from HAPPHY.
Topics: Adrenergic beta-Antagonists; Adult; Atenolol; Benzothiadiazines; Clinical Protocols; Coronary Diseas | 1988 |
Long-term reduction of peripheral resistance with celiprolol and effects on left ventricular mass.
Topics: Adrenergic beta-Antagonists; Adult; Blood Flow Velocity; Blood Pressure; Celiprolol; Clinical Trials | 1988 |
Effects of acute and chronic beta-adrenoceptor blockade on baroreflex sensitivity in humans.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Blood Pressure; Female; Heart Rate; | 1988 |
A comparative study of ketanserin and metoprolol in essential hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; | 1985 |
The effect of weight reduction on left ventricular mass. A randomized controlled trial in young, overweight hypertensive patients.
Topics: Adult; Blood Pressure; Body Weight; Cardiac Volume; Cardiomegaly; Clinical Trials as Topic; Diet, Re | 1986 |
A comparative study of ketanserin and metoprolol in essential hypertension.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Female; Heart Rate; Huma | 1986 |
Long-term safety and efficacy of ketanserin in essential hypertension: ketanserin versus or in combination with metoprolol.
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Human | 1986 |
Ketanserin versus metoprolol in the treatment of essential hypertension.
Topics: Adult; Aged; Female; Follow-Up Studies; Heart Rate; Humans; Hypertension; Ketanserin; Male; Metoprol | 1986 |
Clinical experience with ketanserin in the treatment of hypertension.
Topics: Double-Blind Method; Heart Rate; Humans; Hypertension; Ketanserin; Metoprolol; Piperidines | 1986 |
The antihypertensive effects of doxazosin: a clinical overview.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Atenolol; Blood Pressure; Cholesterol; Cholesterol | 1986 |
QRS-amplitudes during antihypertensive treatment: a comparison between beta-blocker and thiazide diuretic regimens.
Topics: Adult; Aged; Blood Pressure; Cardiomegaly; Clinical Trials as Topic; Coronary Disease; Electrocardio | 1986 |
[Antihypertensive effectiveness and tolerance of slow-release metoprolol in fixed combination with chlorthalidone. Multicenter study on 93 patients].
Topics: Chlorthalidone; Clinical Trials as Topic; Delayed-Action Preparations; Female; Humans; Hypertension; | 1987 |
Treatment of high blood pressure in overweight patients.
Topics: Adult; Blood Pressure; Body Weight; Cardiac Volume; Cardiomegaly; Clinical Trials as Topic; Diet, Re | 1987 |
Exercise blood pressure and heart rate reduction 24 and 3 hours after drug intake in hypertensive patients following 4 weeks of treatment with bisoprolol and metoprolol: a randomized multicentre double-blind study (BISOMET).
Topics: Adolescent; Adult; Aged; Bisoprolol; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; | 1987 |
[Modification of the autonomic vascular reaction and peripheral circulation in the handgrip and orthostasis test by beta-blockage in patients with and without peripheral arterial occlusive disease].
Topics: Adult; Aged; Arousal; Arterial Occlusive Diseases; Blood Pressure; Celiprolol; Clinical Trials as To | 1988 |
Effect of metoprolol and propranolol on platelet aggregation and cAMP level in hypertensive patients.
Topics: Adenosine Diphosphate; Adult; Aged; Cyclic AMP; Epinephrine; Female; Humans; Hypertension; Male; Met | 1986 |
[Double-blind comparative study of the efficacy of metoprolol and hydrochlorothiazide in the elderly hypertensive. Italian results of an international multicenter study].
Topics: Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Hydrochlorothiazide; Hypertensi | 1988 |
[Evaluation of the hypotensive effect of metoprolol (Betaloc-Astra)].
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Female; Humans; Hype | 1988 |
The combination of a low-Na/high-K salt with metoprolol in the treatment of mild-moderate hypertension. A multicenter study.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Diet; Female; Humans; Hypertension; Male; Met | 1988 |
Effects of a low-sodium high-potassium salt in hypertensive patients treated with metoprolol: a multicentre study.
Topics: Blood Pressure; Combined Modality Therapy; Double-Blind Method; Female; Humans; Hypertension; Male; | 1988 |
[Long-term treatment of hypertension with a selective beta l-blocker without sympathomimetic activity. I. Antihypertensive and hemodynamic effects].
Topics: Adult; Clinical Trials as Topic; Female; Hemodynamics; Humans; Hypertension; Male; Metoprolol; Middl | 1988 |
[Comparative effects of metoprolol and acebutolol in primary arterial hypertension].
Topics: Acebutolol; Adult; Aged; Blood Pressure; Clinical Trials as Topic; Female; Humans; Hypertension; Mal | 1988 |
Comparative evaluation of captopril and metoprolol as first choice anti-hypertensive in Indian patients.
Topics: Adult; Aged; Captopril; Clinical Trials as Topic; Humans; Hypertension; Metoprolol; Middle Aged; Ran | 1988 |
Acute and long-term effect of antihypertensive treatment on exercise induced microalbuminuria in essential hypertension.
Topics: Adult; Albuminuria; Atenolol; beta 2-Microglobulin; Blood Pressure; Clinical Trials as Topic; Double | 1987 |
Treating hypertension in black compared with white non-insulin dependent diabetics: a double blind trial of verapamil and metoprolol.
Topics: Aged; Albuminuria; Black or African American; Clinical Trials as Topic; Diabetes Mellitus, Type 2; D | 1988 |
Cardiovascular effects of ketanserin, a new antiserotonergic agent in the treatment of arterial hypertension.
Topics: Adult; Blood Pressure; Body Weight; Exercise Test; Heart Rate; Hemodynamics; Humans; Hypertension; K | 1985 |
Correcting for the bias caused by drop-outs in hypertension trials.
Topics: Clinical Trials as Topic; Data Interpretation, Statistical; Double-Blind Method; Humans; Hypertensio | 1988 |
No difference in general well-being during antihypertensive treatment with atenolol or metoprolol CR.
Topics: Atenolol; Blood Pressure; Health Status; Heart Rate; Humans; Hypertension; Metoprolol; Quality of Li | 1988 |
The effect of beta-blockers on mental performance on older hypertensive patients.
Topics: Aged; Aged, 80 and over; Atenolol; Attention; Blood Pressure; Clinical Trials as Topic; Double-Blind | 1988 |
Diuretics and hypertension in black adults.
Topics: Adult; Black People; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Hydrochlorothiazid | 1988 |
A double-blind comparison of felodipine and hydrochlorothiazide added to metoprolol to control hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Dizziness; Double-Bl | 1988 |
[A randomized comparison between acebutolol and metoprolol in 215 patients with hypertension. Significance of the self-stimulating effect and awareness of the occurrence of adverse effects].
Topics: Acebutolol; Adolescent; Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; | 1988 |
[Metoprolol in the treatment of hypertension].
Topics: Adult; Blood Pressure; Clinical Trials as Topic; Female; Heart Rate; Humans; Hypertension; Male; Met | 1988 |
Are effects of antihypertensive treatment on lipoproteins merely "side-effects"? A comparison of prazosin and metoprolol.
Topics: Clinical Trials as Topic; Female; Humans; Hypertension; Lipids; Lipoproteins; Male; Metoprolol; Midd | 1988 |
Effects of chronic antihypertensive treatment with ketanserin versus metoprolol on blood pressure and large arteries' compliance in humans: a cross-over double-blind study.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Brachial Artery; Cardiac Output; Compliance; Double- | 1988 |
New concepts in the treatment of elderly hypertensive patients.
Topics: Aged; Aging; Antihypertensive Agents; Clinical Trials as Topic; Heart Failure; Heart Ventricles; Hum | 1988 |
The Safety After Fifty Evaluation trial: evaluation of the safety and efficacy of antihypertensive therapy with metoprolol in patients 50 to 75 years of age: study design.
Topics: Aged; Benzothiadiazines; Blood Pressure; Clinical Trials as Topic; Diuretics; Drug Therapy, Combinat | 1988 |
Thromboatherosclerotic complications in hypertensives: results of the Stockholm Metoprolol (secondary prevention) Trial.
Topics: Arteriosclerosis; Cause of Death; Clinical Trials as Topic; Double-Blind Method; Humans; Hypertensio | 1988 |
Primary prevention in patients with hypertension: comments on the clinical implications of the MAPHY Study. Metoprolol Atherosclerosis Prevention in Hypertensives Study.
Topics: Adult; Cause of Death; Clinical Trials as Topic; Coronary Disease; Diuretics; Drug Therapy, Combinat | 1988 |
Ventricular dysrhythmias in middle-aged hypertensive men treated either with a diuretic agent or a beta-blocker.
Topics: Aged; Amiloride; Arrhythmias, Cardiac; Bendroflumethiazide; Clinical Trials as Topic; Drug Combinati | 1987 |
Control of hypertension in elderly patients with felodipine and metoprolol: a double-blind, placebo-controlled clinical trial.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Felodi | 1987 |
Follow-up of a method of twenty-four-hour indirect blood pressure monitoring: evaluation of carvedilol, a new antihypertensive agent.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Carbazoles; Carvedilol | 1987 |
Beta-adrenoceptor stimulating and blocking agents in essential hypertension: single and combined therapy with terbutaline and metoprolol.
Topics: Adult; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Fem | 1987 |
Beta-blockers and cardioprotection--is there any good news from the recent trials?
Topics: Clinical Trials as Topic; Humans; Hypertension; Metoprolol | 1987 |
Hypertension in the elderly. Its diagnosis in general practice and treatment with felodipine and metoprolol.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Double-B | 1987 |
Primary prevention with metoprolol in patients with hypertension. Mortality results from the MAPHY study.
Topics: Adult; Benzothiadiazines; Cardiovascular Diseases; Cerebrovascular Disorders; Coronary Disease; Diur | 1988 |
The systolic hypertension in the elderly pilot program: methodological issues.
Topics: Age Factors; Aged; Aged, 80 and over; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Doub | 1988 |
Renal function effects of dilevalol, a nonselective beta-adrenergic blocking drug with beta-2 agonist activity.
Topics: Administration, Oral; Adult; Aged; Atenolol; Double-Blind Method; Female; Glomerular Filtration Rate | 1988 |
Effect of controlled-release metoprolol on blood pressure and exercise heart rate in hypertension: a comparison with conventional tablets.
Topics: Adult; Blood Pressure; Delayed-Action Preparations; Double-Blind Method; Drug Administration Schedul | 1988 |
Efficacy and tolerability of a new controlled-release formulation of metoprolol: a comparison with conventional metoprolol tablets in mild to moderate hypertension.
Topics: Blood Pressure; Delayed-Action Preparations; Drug Tolerance; Female; Heart Rate; Humans; Hypertensio | 1988 |
Antihypertensive treatment with metoprolol or hydrochlorothiazide in patients aged 60 to 75 years. Report from a double-blind international multicenter study.
Topics: Aged; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Fema | 1986 |
Haemodynamic effects of pretreatment with metoprolol in hypertensive patients undergoing surgery.
Topics: Adult; Aged; Anesthesia, General; Blood Pressure; Cholecystectomy; Clinical Trials as Topic; Electro | 1986 |
The effects of acebutolol and metoprolol on walking distances and distal blood pressure in hypertensive patients with intermittent claudication.
Topics: Acebutolol; Aged; Blood Pressure; Clinical Trials as Topic; Female; Hemodynamics; Humans; Hypertensi | 1986 |
Reduction of nonfatal reinfarctions in patients with a history of hypertension by chronic postinfarction treatment with metoprolol.
Topics: Clinical Trials as Topic; Double-Blind Method; Female; Follow-Up Studies; Humans; Hypertension; Male | 1986 |
Comparison of the antihypertensive effect of urapidil and metoprolol in hypertension.
Topics: Adult; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Female; Heart Rate; Humans; Hy | 1986 |
Effects of beta 1-adrenoceptor blockade in the treatment of hypertension during pregnancy in diabetic women.
Topics: Adult; Atenolol; Blood Glucose; Blood Pressure; Clinical Trials as Topic; Female; Humans; Hypertensi | 1986 |
Ketanserin in the treatment of essential hypertension. A double-blind study against metoprolol and a further long-term open treatment.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Female; Heart Rate; Huma | 1986 |
Comparison of ketanserin and metoprolol in the treatment of essential hypertension.
Topics: Blood Pressure; Clinical Trials as Topic; Female; Heart Rate; Humans; Hypertension; Ketanserin; Male | 1987 |
Double-blind, randomized, cross-over clinical trial of metoprolol and propranolol in mild to moderate essential hypertension.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Hyperten | 1987 |
The effects of propranolol and metoprolol on skin blood flow in diabetic patients.
Topics: Adult; Aged; Diabetes Complications; Diabetes Mellitus; Female; Humans; Hypertension; Male; Metoprol | 1987 |
Plasma catecholamines following exercise in hypertensives treated with pindolol: comparison with placebo and metoprolol.
Topics: Adult; Aged; Catecholamines; Double-Blind Method; Female; Heart Rate; Humans; Hypertension; Male; Me | 1986 |
Effect of beta-blockers on plasma lipids.
Topics: Adult; Atenolol; Blood Pressure; Cholesterol; Female; Heart Rate; Humans; Hypertension; Lipids; Male | 1986 |
Effects of two doses of the fixed-combination chlorthalidone and slow-release metoprolol on blood pressure at rest and during exercise: a multicenter study.
Topics: Adult; Aged; Chlorthalidone; Double-Blind Method; Drug Combinations; Exercise Test; Female; Humans; | 1986 |
Metoprolol in the aged hypertensive: a comparison of two dosage schedules.
Topics: Aged; Clinical Trials as Topic; Double-Blind Method; Drug Administration Schedule; Female; Humans; H | 1985 |
Effects of felodipine on rest and exercise heart rate and blood pressure in hypertensive patients.
Topics: Adult; Antihypertensive Agents; Bendroflumethiazide; Blood Pressure; Clinical Trials as Topic; Doubl | 1985 |
Hypertension in the elderly.
Topics: Aged; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hype | 1985 |
[Pindolol versus metoprolol. An echocardiographic evaluation of left ventricular function in the 2 regimes].
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Echocardiography; Female; Heart Ventricles; Hu | 1985 |
A prospective controlled trial of metoprolol-hydralazine treatment in hypertension during pregnancy.
Topics: Adult; Clinical Trials as Topic; Drug Therapy, Combination; Female; Fetus; Gestational Age; Humans; | 1985 |
[Treatment of arterial hypertension with a combination metoprolol-hydrochlorothiazide].
Topics: Blood Pressure; Clinical Trials as Topic; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hy | 1985 |
[Prolonged treatment with ketanserin in essential hypertension and comparison with metoprolol].
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Female; Humans; Hypertension; Ketanserin; Mal | 1985 |
Hemodynamics of metoprolol and pindolol in systemic hypertension with particular reference to reversal of structural vascular changes.
Topics: Adult; Blood Pressure; Blood Vessels; Female; Heart Rate; Hemodynamics; Humans; Hypertension; Male; | 1986 |
The relative antihypertensive potency of propranolol, oxprenolol, atenolol, and metoprolol given once daily. A double-blind, crossover, placebo-controlled study in ambulatory patients.
Topics: Adult; Aged; Analysis of Variance; Atenolol; Blood Pressure; Body Weight; Delayed-Action Preparation | 1985 |
Comparison of the duration of antihypertensive action of atenolol and metoprolol over a 24-hour period.
Topics: Adult; Aged; Atenolol; Blood Pressure; Double-Blind Method; Female; Heart Rate; Humans; Hypertension | 1985 |
Ventilatory effects of long-term treatment with pindolol and metoprolol in hypertensive patients with chronic obstructive lung disease.
Topics: Adult; Female; Forced Expiratory Volume; Humans; Hypertension; Lung Diseases, Obstructive; Male; Met | 1985 |
Comparison of two slow-release formulations of metoprolol with conventional metoprolol and atenolol in hypertensive patients.
Topics: Adult; Aged; Atenolol; Delayed-Action Preparations; Exercise Test; Female; Humans; Hypertension; Mal | 1985 |
416 other studies available for metoprolol and Blood Pressure, High
| Article | Year |
|---|---|
Identifying drug-related attributes to personalise antihypertensive agents: the outcome report of patients receiving metoprolol therapy.
Topics: Antihypertensive Agents; Blood Pressure; Humans; Hypertension; Metoprolol; Pharmaceutical Preparatio | 2021 |
Evaluation of a Beta-Blocker-Edema-Loop Diuretic Prescribing Cascade: A Prescription Sequence Symmetry Analysis.
Topics: Adrenergic beta-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents | 2022 |
Nebivolol and incident cardiovascular events in hypertensive patients compared with nonvasodilatory beta blockers.
Topics: Adrenergic beta-Antagonists; Adult; Female; Humans; Hypertension; Male; Metoprolol; Nebivolol; Retro | 2022 |
Blood pressure response to commonly administered antihypertensives for severe inpatient hypertension.
Topics: Adult; Amlodipine; Antihypertensive Agents; Blood Pressure; Carvedilol; Cohort Studies; Humans; Hydr | 2022 |
Physiologically based pharmacokinetic modelling to predict the pharmacokinetics of metoprolol in different CYP2D6 genotypes.
Topics: Cytochrome P-450 CYP2D6; Genotype; Humans; Hypertension; Metoprolol; Pharmacogenetics | 2022 |
Estimating the prevalence of hypertension in 164 cities in China by wastewater-based epidemiology.
Topics: Adult; Aged; Biomarkers; China; Chromatography, Liquid; Cities; Humans; Hypertension; Metoprolol; Mi | 2023 |
Improvement in hemodynamics of amlodipine besylate combined with metoprolol in patients with hypertension complicated by heart failure.
Topics: Amlodipine; Heart Failure; Hemodynamics; Humans; Hypertension; Metoprolol | 2023 |
A High Throughput HPLC-MS/MS Method for Antihypertensive Drugs Determination in Plasma and Its Application on Pharmacokinetic Interaction Study with Shuxuetong Injection in Rats.
Topics: Animals; Antihypertensive Agents; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; High- | 2019 |
Neonatal effects of intrauterine metoprolol/bisoprolol exposure during the second and third trimester: a cohort study with two comparison groups.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Birth Weight; Bisoprolol; Cohort Studies; Fema | 2020 |
Association between beta-blocker use and obesity in Hong Kong Chinese elders: a post-hoc analysis.
Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Asian People; Atenolol; Blood Pressure; Body M | 2020 |
Metabolomic profiling of metoprolol hypertension treatment reveals altered gut microbiota-derived urinary metabolites.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Bacteria; Blood Pressure; Female; Gastroint | 2020 |
The comparison of side effects of methyldopa, amlodipine, and metoprolol in pregnant women with chronic hypertension.
Topics: Adult; Amlodipine; Antihypertensive Agents; Blood Pressure; Female; Humans; Hypertension; Incidence; | 2020 |
β-blockade prevents coronary macro- and microvascular dysfunction induced by a high salt diet and insulin resistance in the Goto-Kakizaki rat.
Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Carvedilol; Coronary A | 2021 |
Assessing Adherence to Antihypertensive Medication by Means of Dose-Dependent Reference Plasma Concentration Ranges and Ultra-High Performance Liquid Chromatography-Ion Trap Mass Spectrometry Analysis.
Topics: Amlodipine; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Body Fluids; Chromatography | 2021 |
Effects of garden cress, fenugreek and black seed on the pharmacodynamics of metoprolol: an herb-drug interaction study in rats with hypertension.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cytochrome P-450 CYP2D6; Disease Models, Animal; H | 2021 |
Wide Complex Ventricular Rhythm in a Patient After Collapse.
Topics: Aged, 80 and over; Antihypertensive Agents; Arrhythmias, Cardiac; Bradycardia; Electrocardiography; | 2017 |
β-Blocker Exposure in Pregnancy and Risk of Fetal Cardiac Anomalies.
Topics: Adrenergic beta-Antagonists; Age Factors; Arrhythmias, Cardiac; Atenolol; Body Mass Index; Californi | 2017 |
Renal denervation decreases blood pressure and renal tyrosine hydroxylase but does not augment the effect of hypotensive drugs.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Hypertension; Indapamide; Losartan; Male; Metop | 2017 |
Blood pressure response to metoprolol and chlorthalidone in European and African Americans with hypertension.
Topics: Adult; Age Factors; Aged; Antihypertensive Agents; Black or African American; Blood Pressure; Chlort | 2017 |
Nebivolol, But Not Metoprolol, Treatment Improves Endothelial Fibrinolytic Capacity in Adults With Elevated Blood Pressure.
Topics: Adrenergic beta-1 Receptor Antagonists; Blood Pressure; Dose-Response Relationship, Drug; Double-Bli | 2017 |
Can aldosterone break your heart? Takotsubo cardiomyopathy in a patient with newly diagnosed primary aldosteronism.
Topics: Aldosterone; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agen | 2018 |
Modulation of cardiac stem cell characteristics by metoprolol in hypertensive heart disease.
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Cardiomegaly; Cell Movement; Cell Proliferatio | 2018 |
Inadvertent Left Ventricle Endocardial or Uncomplicated Right Ventricular Pacing: How to Differentiate in the Emergency Department.
Topics: Aged; Anticoagulants; Antihypertensive Agents; Atrial Fibrillation; Cardiac Pacing, Artificial; Diag | 2018 |
β-blockers interfere with cell homing receptors and regulatory proteins in a model of spontaneously hypertensive rats.
Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Antihypertensive Agent | 2018 |
A retrospective study evaluating the tolerability and effectiveness of adjunctive antihypertensive drugs in patients with inadequate response to initial treatment.
Topics: Adult; Aged; Amlodipine; Antihypertensive Agents; Drug-Related Side Effects and Adverse Reactions; F | 2018 |
Insights on β-blockers for the treatment of hypertension: A survey of health care practitioners.
Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Antihypertensive Agents; Atenolol; Black or Af | 2018 |
Association of histamine with hypertension-induced cardiac remodeling and reduction of hypertrophy with the histamine-2-receptor antagonist famotidine compared with the beta-blocker metoprolol.
Topics: Adrenergic beta-1 Receptor Antagonists; Age Factors; Animals; Blood Pressure; Cardiomegaly; Famotidi | 2018 |
Reliable and easy-to-use LC-MS/MS-method for simultaneous determination of the antihypertensives metoprolol, amlodipine, canrenone and hydrochlorothiazide in patients with therapy-refractory arterial hypertension.
Topics: Amlodipine; Antihypertensive Agents; Canrenone; Carbon Isotopes; Chromatography, High Pressure Liqui | 2019 |
A Young Woman With Chest Pain.
Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Aortic Dissection; Aspirin; Chest Pain; Clopidogrel; | 2018 |
Comparing PyroMark Q24 Pyrosequencing and MALDI-TOF MS for Identification of CYP2D6*10.
Topics: Aged; Antihypertensive Agents; Asian People; China; Cost-Benefit Analysis; Cytochrome P-450 CYP2D6; | 2019 |
Cytochrome P450 2D6 phenotype and genotype in hypertensive patients on long-term therapy with metoprolol.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Cytochrome P-450 CYP2D6; Female; Genotype; | 2013 |
Clinically important interaction between metoprolol and propafenone.
Topics: Aged; Anti-Arrhythmia Agents; Antihypertensive Agents; Atrial Fibrillation; Cytochrome P-450 CYP2D6; | 2013 |
Effect of Xinjikang on left ventricular hypertrophy remodeling in hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Drugs, Chinese Herbal; Female; Hypertension; Male; | 2013 |
Metoprolol restores expression and vasodilatation function of AT2R in spontaneously hypertensive rats.
Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Benzoates; | 2014 |
Impact of CYP2D6 polymorphisms on clinical efficacy and tolerability of metoprolol tartrate.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Cytochrome P-450 CYP2D6; Depression; Fatigue; Female | 2014 |
Economic impact of switching from metoprolol to nebivolol for hypertension treatment: a retrospective database analysis.
Topics: Adult; Aged; Aged, 80 and over; Benzopyrans; Ethanolamines; Female; Health Expenditures; Hospitaliza | 2014 |
Critical conversations after coronary artery bypass grafting: balancing the evidence and dealing with uncertainty.
Topics: Antihypertensive Agents; Arrhythmias, Cardiac; Coronary Artery Bypass; Evidence-Based Medicine; Huma | 2014 |
Effects of antihypertensive treatment on cardiovascular autonomic control: a prospective study.
Topics: Antihypertensive Agents; Atenolol; Atrial Fibrillation; Autonomic Nervous System; Cohort Studies; En | 2014 |
Cyclic guanosine monophosphate modulation and blood pressure.
Topics: Benzopyrans; Blood Pressure; Ethanolamines; Female; Humans; Hypertension; Male; Metoprolol; Nebivolo | 2014 |
Autoantibodies against β1 receptor and AT1 receptor in type 2 diabetes patients with left ventricular dilatation.
Topics: Aged; Antihypertensive Agents; Autoantibodies; Biomarkers; Diabetes Mellitus, Type 2; Dilatation, Pa | 2014 |
Combination Treatment With Antihypertensive Agents Enhances the Effect of Qiliqiangxin on Chronic Pressure Overload-induced Cardiac Hypertrophy and Remodeling in Male Mice.
Topics: Adrenergic beta-Antagonists; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme | 2015 |
Associations between ADRB1 and CYP2D6 gene polymorphisms and the response to β-blocker therapy in hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; China; Cytochrome | 2015 |
CYP 2D6*4 polymorphism and interindividual response variation to metoprolol in stage 1 hypertensive patients: no association in a rural Indian population?
Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Blood Pressure; Cytochrome P-450 CYP2D6; Delayed-Acti | 2015 |
TSC-22 up-regulates collagen 3a1 gene expression in the rat heart.
Topics: Animals; Antihypertensive Agents; Cells, Cultured; Collagen Type III; Female; Gene Expression; Gene | 2015 |
Acute renal failure and arterial hypertension due to subcapsular haematoma: is percutaneous drainage a feasible treatment?
Topics: Acute Kidney Injury; Aged; Antihypertensive Agents; Bendroflumethiazide; Blood Pressure; Drainage; F | 2016 |
Ask the doctor. I'm a healthy 58-year-old man recently diagnosed with high blood pressure. My doctor prescribed metoprolol, and my blood pressure is now in the normal range. But I've started having trouble getting an erection. Could the medication be c
Topics: Antihypertensive Agents; Erectile Dysfunction; Humans; Hypertension; Male; Metoprolol; Middle Aged | 2014 |
Heart rate dependent and independent effects of beta-blockers on central hemodynamic parameters: a propensity score analysis.
Topics: Adrenergic beta-1 Receptor Antagonists; Aged; Atenolol; Bisoprolol; Blood Pressure; Cross-Sectional | 2016 |
Pharmacokinetic considerations in the treatment of hypertension in risperidone-medicated patients - thinking of clinically relevant CYP2D6 interactions.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amlodipine; Antihypertensive Agents; Antipsychotic Agent | 2016 |
Late Pregnancy β Blocker Exposure and Risks of Neonatal Hypoglycemia and Bradycardia.
Topics: Adrenergic beta-Antagonists; Atenolol; Bradycardia; Cohort Studies; Female; Humans; Hypertension; Hy | 2016 |
Downregulation of the β1 adrenergic receptor in the myocardium results in insensitivity to metoprolol and reduces blood pressure in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cell Line; Dependovirus; Down-Regulation; Genetic | 2017 |
[Regulatory Adaptive Status in Assessment of Efficacy of Pharmacotherapy and Prognostication of Complications in Functional Class III Chronic Heart Failure].
Topics: Aged; Benzazepines; Cardiovascular Agents; Chronic Disease; Echocardiography; Exercise Test; Female; | 2016 |
Cardiogenic shock following nasal septoplasty: a case report and review of the literature.
Topics: Adrenergic beta-Antagonists; Adult; Epinephrine; Humans; Hypertension; Male; Metoprolol; Nasal Septu | 2008 |
Noradrenergic modulation of subthalamic nucleus activity in human: metoprolol reduces spiking activity in microelectrode recordings during deep brain stimulation surgery for Parkinson's disease.
Topics: Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; Deep Brain Stimulation; Electroencephalo | 2008 |
Genetic variation in the CYP2D6 gene is associated with a lower heart rate and blood pressure in beta-blocker users.
Topics: Adrenergic beta-Antagonists; Aged; Blood Pressure; Cross-Sectional Studies; Cytochrome P-450 CYP2D6; | 2009 |
DNA methylation might be the epigenetic molecular mechanism of different antihypertensive efficacy of metoprolol in beta1-AR gene-directed therapy.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; DNA Methylation; Genetic Predisposition to Dis | 2009 |
Dilated cardiomyopathy with hypertension: prevalence and response to high-dose β1-adrenoceptor antagonist therapy.
Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Analysis of Variance; Antihypertensive Agents; Blood | 2009 |
[67-year-old patient with abdominal pain and pronounced peritonitis].
Topics: Abdominal Pain; Aged; Angioedema; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; | 2009 |
Loss of arterial and renal nitric oxide bioavailability in hypertensive rats with diabetes: effect of beta-blockers.
Topics: Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Arteries; Benzopyrans; Blood Glucose; | 2009 |
Gas chromatography-mass spectrometry method for determination of metoprolol in the patients with hypertension.
Topics: Antihypertensive Agents; Area Under Curve; Calibration; Gas Chromatography-Mass Spectrometry; Humans | 2009 |
[Beta blockers in hypertension treatment Will stepping back come soon?].
Topics: Adrenergic beta-Antagonists; Age Factors; Aged; Antihypertensive Agents; Atenolol; Clinical Trials a | 2007 |
Metoprolol treatment lowers thrombospondin-4 expression in rats with myocardial infarction and left ventricular hypertrophy.
Topics: Animals; Antihypertensive Agents; Hypertension; Hypertrophy, Left Ventricular; Male; Metoprolol; Myo | 2010 |
[Response to metoprolol succinate sustained-release tablets in correlation to pulse pressure, serum vascular endothelial growth factor and C-reactive protein in elderly hypertensive patients with chronic heart failure].
Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Blood Pressure; C-Reactive Protein; Chronic Di | 2010 |
Resistant hypertension responding to change from furosemide to thiazide: understanding calcium channel blocker-related edema.
Topics: Adrenergic beta-1 Receptor Antagonists; Aged; Blood Pressure; Calcium Channel Blockers; Drug Therapy | 2010 |
Myoclonus after dextromethorphan administration in peritoneal dialysis.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Antitussive Agents; Cough; Cytochrome P-450 CY | 2011 |
[Hypertensive disease and metabolic syndrome: application of metoprolol].
Topics: Adrenergic beta-1 Receptor Antagonists; Cerebrovascular Circulation; Dose-Response Relationship, Dru | 2010 |
Hemodynamic instability during resection of pheochromocytoma in MEN versus non-MEN patients.
Topics: Adrenal Gland Neoplasms; Adrenergic alpha-1 Receptor Antagonists; Adrenergic beta-1 Receptor Antagon | 2011 |
Rate-limiting step: can different effects of antihypertensives on central blood pressure be translated into outcomes?
Topics: Antihypertensive Agents; Aorta; Benzopyrans; Blood Pressure; Carotid Arteries; Ethanolamines; Femora | 2011 |
Mixed messages on blood pressure goals.
Topics: Amlodipine; Antihypertensive Agents; Black or African American; Blood Pressure; Glomerular Filtratio | 2011 |
Chronic β-adrenoceptor antagonist treatment controls cardiovascular remodeling in heart failure in the aging spontaneously hypertensive rat.
Topics: Adrenergic beta-1 Receptor Antagonists; Aging; Animals; Blood Pressure; Disease Models, Animal; Dose | 2011 |
Metoprolol ameliorates cyclosporine a-induced hypertension and nephrotoxicity in rats.
Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Antioxidants; Blood Pressure; Carbachol; Cyclospori | 2011 |
Persistence with nebivolol in the treatment of hypertension: a retrospective claims analysis.
Topics: Adult; Aged; Antihypertensive Agents; Atenolol; Benzopyrans; Carbazoles; Carvedilol; Databases, Fact | 2012 |
Disrupted regulation of ghrelin production under antihypertensive treatment in spontaneously hypertensive rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic beta-1 Receptor Antagonists; Angiotensin II Type | 2012 |
Aquaporin changes during diabetic retinopathy in rats are accelerated by systemic hypertension and are linked to the renin-angiotensin system.
Topics: Adrenergic beta-1 Receptor Antagonists; Angiotensin II Type 1 Receptor Blockers; Animals; Aquaporins | 2012 |
Effects of antihypertensive therapy on female sexual dysfunction: clinically meaningful?
Topics: Antihypertensive Agents; Biphenyl Compounds; Felodipine; Female; Humans; Hypertension; Metoprolol; O | 2012 |
Unsuspected pheochromocytoma of the urinary bladder: reminder of an important clinical lesson.
Topics: Adult; Antihypertensive Agents; Cystectomy; Cystoscopy; Headache; Hematuria; Humans; Hypertension; M | 2012 |
Cardioselective beta-blocker treatment of hypertension in patients with asthma: when do benefits outweigh risks?
Topics: Adrenergic beta-1 Receptor Antagonists; Asthma; Atenolol; Dose-Response Relationship, Drug; Humans; | 2012 |
My mother was put on the betablocker metoprolol (Toprol) for high blood pressure. Now she thinks her diabetes is out of control because of it. Can this be possible?
Topics: Adrenergic beta-Antagonists; Aged; Blood Glucose; Blood Pressure; Body Weight; Female; Humans; Hyper | 2011 |
[Diurnal profile of arterial pressure during sleep deprivation in patients with hypertensive disease receiving antihypertensive therapy].
Topics: Adult; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Circadian Rhy | 2012 |
Pharmacogenetics and other reasons why drugs can fail in pregnancy: higher dose or different drug?
Topics: Antihypertensive Agents; Chronic Disease; Cytochrome P-450 CYP2D6; Drug Substitution; Female; Humans | 2012 |
Palmar psoriasis, a rare side effect of beta-blocker theraphy: a case report.
Topics: Adrenergic beta-Antagonists; Humans; Hypertension; Iatrogenic Disease; Metoprolol; Psoriasis | 2012 |
48-year-old man with cough and leg swelling.
Topics: Acute Disease; Antihypertensive Agents; Cerebrovascular Circulation; Cough; Dyspnea; Echocardiograph | 2012 |
Effect of the CYP2D6 genotype on metoprolol metabolism persists during long-term treatment.
Topics: Adrenergic beta-Antagonists; Chromatography, High Pressure Liquid; Cohort Studies; Coronary Artery D | 2002 |
[The use of combination therapy with lacidipine and beta-adrenoblockers in patients with hypertension].
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Atenolol; Blood Pressure; Dihydropyridines; Dr | 2002 |
[Changes of distensibility of the aorta in elderly patients during long-term therapy with various classes of hypotensive drugs (magnetic resonance tomography data)].
Topics: Adrenergic beta-Antagonists; Age Factors; Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors | 2002 |
[Complex assessment of efficacy and tolerance of metoprolol CR/ZOK in treating hypertension].
Topics: Adrenergic beta-Antagonists; Adult; Antihypertensive Agents; Female; Humans; Hypertension; Male; Met | 2002 |
Dosage conversions as a potential cause of adverse drug events.
Topics: Administration, Oral; Antihypertensive Agents; Biological Availability; Dose-Response Relationship, | 2003 |
Overexpression of eNOS in RVLM improves impaired baroreflex control of heart rate in SHRSP. Rostral ventrolateral medulla. Stroke-prone spontaneously hypertensive rats.
Topics: Animals; Atropine; Autonomic Agents; Baroreflex; beta-Galactosidase; Blood Pressure; Gene Expression | 2003 |
Role of metoprolol, B1-adrenoceptor antagonist, thromboxane A2 and nitric oxide in CsA-induced hypertension.
Topics: Adrenergic beta-Antagonists; Animals; Aorta, Thoracic; Cyclosporine; Enzyme Activation; Hypertension | 2003 |
In vivo and in vitro pharmacodynamic properties of metoprolol in aortic coarctated rats.
Topics: Animals; Aortic Coarctation; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Dru | 2003 |
[Clinical significance of adrenoreactivity in patients with some paroxysmal disorders (panic attacks and migraine)].
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Citalopram; Diagnostic and Statistical Manual of Men | 2003 |
[Moxonidine is advantageous for hypertensive type 2 diabetic patients. Therapy of hypertension also lowers HbA1c].
Topics: Antihypertensive Agents; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Glycated Hemoglobin; H | 2003 |
Beta 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol.
Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Aged; Antihypertensive Agents; Female; Gene Frequency | 2003 |
[Clinical and metabolic effects of cardioselective beta-adrenoblockers nebivolol and metoprolol in patients with hypertension and ischemic heart disease associated with type 2 diabetes].
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Antihypertensive Agents; Benzopyrans; Carbohydrate Met | 2003 |
Effects of moxonidine and metoprolol in penile circulation in hypertensive men with erectile dysfunction: results of a pilot study.
Topics: Adult; Antihypertensive Agents; Arteries; Blood Flow Velocity; Cross-Over Studies; Drug Administrati | 2003 |
Effects of a beta blocker and spironolactone on plasma homocysteine levels.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Biomarkers; Blood Pressure; Diure | 2003 |
Anterior hypothalamic beta-adrenergic activity in the maintenance of hypertension in aortic coarctated rats.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Anterior Hypothalamic Nucleus; Aorti | 2004 |
How should subgroup analyses affect clinical practice? Insights from the Metoprolol Succinate Controlled-Release/Extended-Release Randomized Intervention Trial in Heart Failure (MERIT-HF).
Topics: Adrenergic beta-Antagonists; Black People; Diabetic Angiopathies; Heart Failure; Humans; Hypertensio | 2003 |
Which beta-blocker for heart failure?
Topics: Adrenergic beta-Antagonists; Bisoprolol; Carbazoles; Carvedilol; Contraindications; Coronary Disease | 2004 |
Pheochromocytoma and pregnancy: a case report and review of anesthetic management.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; A | 2004 |
[Antihypertensive first-line and add-on treatment with a fixed controlled release combination of metoprololsuccinate/hydrochlorothiazide. Prospective doctor's office observational study in 14,964 patients].
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Delayed-Action Prepar | 2003 |
[Antihypertensive first-line and add-on treatment with a fixed controlled release combination of metoprololsuccinate/hydrochlorothiazide. Prospective doctor's office observational study in 14,964 patients].
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Delayed-Action Preparations; Drug Combinations | 2003 |
Severe sinus bradycardia after initiation of bupropion therapy: a probable drug-drug interaction with metoprolol.
Topics: Adrenergic beta-Antagonists; Arrhythmia, Sinus; Bradycardia; Bupropion; Dopamine Uptake Inhibitors; | 2004 |
Beneficial effect of cibenzoline on left ventricular pressure gradient with sigmoid septum.
Topics: Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Blood Pressure; Cardiomyopathy, Hypertrophic; Dyspn | 2004 |
Effects of cyclooxygenase inhibition on endothelial function in hypertensive patients treated with angiotensin-converting enzyme inhibitors.
Topics: Administration, Sublingual; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Aspir | 2004 |
Pharmacokinetics and CYP2D6 genotypes do not predict metoprolol adverse events or efficacy in hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Area Under Curve; Blood Pressure; Cytochrome P-450 CYP2D6; | 2004 |
Carvedilol, metoprolol, and insulin resistance.
Topics: Antihypertensive Agents; Carbazoles; Carvedilol; Diabetes Mellitus, Type 2; Humans; Hypertension; In | 2005 |
beta-Blockade and increased dyslipidemia in patients bearing Glu27 variant of beta2 adrenergic receptor gene.
Topics: Adrenergic beta-2 Receptor Antagonists; Adrenergic beta-3 Receptor Antagonists; Adrenergic beta-Anta | 2005 |
Slow supraventricular tachycardia in a patient on beta-blocker therapy.
Topics: Adrenergic beta-Antagonists; Aged; Humans; Hypertension; Male; Metoprolol; Tachycardia, Supraventric | 2005 |
[Effect of the polymorphism of the angiotensin-converting enzyme gene on the drug treatment in patients with chronic heart failure].
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Benz | 2004 |
Hypothalamic antihypertensive effect of metoprolol in chronic aortic coarctated rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antihypertensive Agents; Aortic Coarctation; Female; Heart | 2005 |
[Atenolol or metoprolol as beta-blocker in the treatment of hypertension].
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Atenolol; Humans; Hypertension; Metoprolol; Tr | 2005 |
The effect of beta-blocker use on cyclosporine level in cardiac transplant recipients.
Topics: Absorption; Adrenergic beta-Antagonists; ATP Binding Cassette Transporter, Subfamily B, Member 1; Ca | 2005 |
[Antihypertensive therapy with left cardiac insufficiency].
Topics: Acebutolol; Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive | 2005 |
Medication costs as a primary cause of nonadherence in the elderly.
Topics: Aged; Anticholesteremic Agents; Antihypertensive Agents; Atorvastatin; Coronary Disease; Costs and C | 2006 |
Metoprolol succinate, a selective beta-adrenergic blocker, has no effect on insulin sensitivity.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Cholesterol; Cholesterol, LDL; Female; Glucose | 2006 |
Management of type A aortic dissection and a large pheochromocytoma: a surgical dilemma.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthesia, General; Aortic Aneurysm; Aor | 2006 |
Pharmacokinetic-pharmacodynamic (PK-PD) modeling of cardiovascular effects of metoprolol in spontaneously hypertensive rats: a microdialysis study.
Topics: Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Heart Rate; Hypertens | 2006 |
Thoracic epidural analgesia and antihypertensive therapy: a matter of timing?
Topics: Aged; Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Antihypertensive Agents; Bupivaca | 2006 |
Is there a role for beta-adrenergic blockers in treating hypertension in children?
Topics: Adolescent; Adrenergic beta-Antagonists; Age Factors; Child; Dose-Response Relationship, Drug; Doubl | 2007 |
Valsartan versus lisinopril or extended-release metoprolol in preventing cardiovascular and renal events in patients with hypertension.
Topics: Antihypertensive Agents; Cardiovascular Diseases; Delayed-Action Preparations; Female; Humans; Hyper | 2007 |
Delayed onset of malignant hyperthermia without creatine kinase elevation in a geriatric, ryanodine receptor type 1 gene compound heterozygous patient.
Topics: Aged; Anesthesia, General; Anesthetics, Inhalation; Antihypertensive Agents; Blood Pressure; Colosto | 2007 |
Hypothalamic angiotensinergic-noradrenergic systems interaction in fructose induced hypertension.
Topics: Animals; Antihypertensive Agents; Biphenyl Compounds; Fructose; Hypertension; Hypothalamus; Insulin | 2008 |
Effect of beta-adrenergic and renin-angiotensin system blockade on myocyte apoptosis and oxidative stress in diabetic hypertensive rats.
Topics: Adrenergic beta-Antagonists; Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; Diabetes C | 2007 |
[Beta-adrenoceptor antagonists and ACE-inhibitors. Carvedilol compared with metoprolol as combination partner in cases of diabetes and hypertension].
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Carbazoles; Carvedilol; Diabe | 2007 |
Hospitalization rates of generic metoprolol compared with the original beta-blocker in an epidemiological database study.
Topics: Adrenergic beta-Antagonists; Aged; Arrhythmias, Cardiac; Arthritis, Rheumatoid; Databases, Factual; | 2007 |
Too many zeros in metoprolol.
Topics: Adrenergic beta-Antagonists; Child; Drug Prescriptions; Humans; Hypertension; Medication Errors; Met | 2007 |
[Administration of cardioselective beta-adrenoblockers in patients with arterial hypertension and/or ischemic heart disease associated with bronchoobstructive syndrome].
Topics: Adrenergic beta-Antagonists; Asthma; Benzopyrans; Comorbidity; Drug Administration Schedule; Ethanol | 2007 |
[Pharmacokinetics of enalapril and metoprolol in hypertensive patients with hepatic pathology].
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Chromatography, High Pressure | 2007 |
Renal and cardiac effects of antihypertensive treatment with ramipril versus metoprolol in autosomal dominant polycystic kidney disease.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Hear | 2008 |
Treatment with metoprolol succinate, a selective beta adrenergic blocker, lowers blood pressure without altering insulin sensitivity in diabetic patients.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; Diabetes Mellitus, Type 2; Diabetic Angiop | 2008 |
Effect of nebivolol and metoprolol treatments on serum asymmetric dimethlyarginine levels in hypertensive patients with type 2 diabetes mellitus.
Topics: Adrenergic beta-Antagonists; Arginine; Benzopyrans; Confounding Factors, Epidemiologic; Diabetes Mel | 2008 |
Perioperative myocardial infarction after cesarean section in a young woman with hypertrophic obstructive cardiomyopathy.
Topics: Adrenergic beta-Antagonists; Adult; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Local; | 2008 |
A physician with pounding headaches.
Topics: Adrenergic beta-Antagonists; Adult; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Benzoat | 2008 |
Antihypertensive therapy in a patient with type B and de novo type A aortic dissection: case study.
Topics: Antihypertensive Agents; Aortic Aneurysm; Aortic Dissection; Humans; Hypertension; Male; Metoprolol; | 2007 |
In vitro and in vivo pharmacodynamic properties of metoprolol in fructose-fed hypertensive rats.
Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Antihypertensive Agents; Area Under Curve; Disease | 2008 |
[A case from practice (26). Classical acute shoulder syndrome caused by beta blockers (metoprolol, Lopresor)].
Topics: Aged; Humans; Hypertension; Male; Metoprolol; Reflex Sympathetic Dystrophy | 1984 |
Comparison of the hypotensive and metabolic effects of metoprolol therapy with a high fibre, low sodium, low fat diet in hypertensive type 2 diabetic subjects.
Topics: Blood Pressure; Combined Modality Therapy; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diet, S | 1984 |
Contrasting renal haemodynamic responses to the angiotensin converting enzyme inhibitor enalapril and the beta-adrenergic antagonist metoprolol in essential hypertension.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Double-Blind Method; Enalapril; Fem | 1984 |
A study on the effects of some drugs on DOCA induced hypertension in the rat.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Cardiomegaly; Desoxycorticosterone; Diuretics; H | 1980 |
Pre- and postjunctional beta-adrenoceptor mediated effects on transmitter release and effector response in the isolated rat portal vein.
Topics: Animals; Autacoids; Electric Stimulation; Female; Hypertension; Isoproterenol; Male; Metoprolol; Mus | 1980 |
Low-dose diuretic and beta adrenoceptor blocker in essential hypertension.
Topics: Adrenergic beta-Antagonists; Aldosterone; Analysis of Variance; Black People; Blood Pressure; Diuret | 1980 |
[Cardioselective beta-blocking agents and respiratory function].
Topics: Adrenergic beta-Antagonists; Adult; Atenolol; Female; Humans; Hypertension; Lung Diseases, Obstructi | 1980 |
Activation of prejunctional beta-adrenoceptors in rat atria by adrenaline applied exogenously or released as a co-transmitter.
Topics: Animals; Epinephrine; Hypertension; In Vitro Techniques; Metoprolol; Myocardium; Neurotransmitter Ag | 1981 |
Clinical use of the beta1-selective adrenoceptor blocker metoprolol in hypertension, angina pectoris and arrhythmias.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Arrhythmias, Cardiac; Humans; Hypertension; Metoprolol | 1981 |
Variability in the preventive action of the B-blockers on genetic hypertension in the rat.
Topics: Acebutolol; Adrenergic beta-Antagonists; Alprenolol; Animals; Blood Pressure; Dose-Response Relation | 1980 |
Combined intravenous administration of diazoxide and beta-blocking agent in acute treatment of severe hypertension or hypertensive crisis.
Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Diazoxide; Drug Therapy, Combination; Female; He | 1982 |
Effect of low-dose epinephrine infusion on hemodynamics after selective and nonselective beta-blockade in hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Drug Interactions; Epinephrine; Female; Heart Ra | 1982 |
[Immediate effect of beta receptor blockaders on electrolyte metabolism].
Topics: Adrenergic beta-Antagonists; Electrolytes; Humans; Hypertension; Kidney Failure, Chronic; Metoprolol | 1982 |
[Role of renin profile and age in the choice of the therapeutic approach of arterial hypertension (author's transl)].
Topics: Adrenergic beta-Antagonists; Adult; Age Factors; Aged; Atenolol; Chlorthalidone; Diuretics; Drug The | 1981 |
Clinical experiences with prenalterol as an antidote to Beta-adrenoceptor blockade.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Adult; Aged; Anesthesia; Cardiac Catheterizat | 1982 |
[Acute effects of metoprolol on blood pressure and heart rate. Value of the nitroglycerin test].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; Female; Heart Rate; Humans; Hypertension; | 1982 |
Alterations in left ventricular filling with beta-adrenergic blockade.
Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Diastole; Female; Heart Ventricles; Hemodynamics | 1983 |
Possible significance of the pharmacological differentiation of beta-blocking agents in hemodynamic effects in essential hypertension.
Topics: Acebutolol; Adrenergic beta-Antagonists; Atenolol; Carteolol; Hemodynamics; Humans; Hypertension; Me | 1983 |
Sclerosing peritonitis associated with metoprolol.
Topics: Female; Humans; Hypertension; Metoprolol; Middle Aged; Peritonitis; Propanolamines; Sclerosis | 1983 |
Early aggressive antihypertensive treatment reduces rate of decline in kidney function in diabetic nephropathy.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Diabetes Mellitus; Diabetic Nephropathies; Diuretics | 1983 |
Adrenergic beta-receptor blockers in hypertension of pregnancy.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Birth Weight; Blood Pressure; Delivery, Obstetric; F | 1982 |
Disposition of the adrenergic blocker metoprolol in the late pregnant women, the amniotic fluid, the cord blood and the neonate.
Topics: Adrenergic beta-Antagonists; Amniotic Fluid; Female; Fetal Blood; Humans; Hypertension; Infant, Newb | 1983 |
Central haemodynamic effects of beta blockers in hypertension. A comparison between atenolol, metoprolol, timolol, penbutolol, alprenolol pindolol and bunitrolol.
Topics: Adrenergic beta-Antagonists; Alprenolol; Atenolol; Hemodynamics; Humans; Hypertension; Metoprolol; P | 1983 |
[Peripheral vascular effects of metoprolol, pindolol and propranolol in hypertensive patients].
Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Catecholamines; Female; Hemodynamics; Humans; Hy | 1983 |
Adrenergic blockade and hypoglycaemia.
Topics: Adrenergic beta-Antagonists; Blood Glucose; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Glucag | 1983 |
Essential hypertension. The behaviour of the haemorheological determinants and their trends during beta-blocker treatment.
Topics: Adrenergic beta-Antagonists; Aged; Blood Proteins; Blood Viscosity; Female; Fibrinogen; Hematocrit; | 1983 |
Assessment of optimal dose of diuretic associated with fixed dose of beta-blocking: a new experimental model based on multiple sampling of blood pressure performed by self-measurements.
Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Blood Pressure Determination; Diuretics; Drug Th | 1984 |
Some notes on the hormonal and haemodynamic responses to stressful stimuli.
Topics: Adrenergic beta-Antagonists; Adrenocorticotropic Hormone; Anesthesia, Epidural; Anesthesia, General; | 1984 |
Clinical trials of adrenergic antagonists in pregnancy hypertension.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Apgar Score; Birth Weight; Female; Fetal Growt | 1984 |
Polyarteritis nodosa associated with ulcerative colitis.
Topics: Adolescent; Clonidine; Colectomy; Colitis, Ulcerative; Cyclophosphamide; Humans; Hypertension; Ileos | 1984 |
[Effects of long-term treatment with various antihypertensive drugs on the cardiac mass and on the hemodynamics of patients with essential arterial hypertension].
Topics: Adult; Cardiac Output; Cardiomegaly; Clonidine; Echocardiography; Heart; Humans; Hypertension; Methy | 1983 |
Left ventricular hypertrophy regression in hypertensive patients treated with metoprolol.
Topics: Adult; Blood Pressure; Cardiomegaly; Catecholamines; Echocardiography; Hemodynamics; Humans; Hyperte | 1984 |
Regression of structural cardiovascular changes by antihypertensive therapy in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Cardiovascular System; Circadian Rhy | 1984 |
Update on drug therapy: III. Metoprolol.
Topics: Angina Pectoris; Humans; Hypertension; Metoprolol; Propanolamines | 1980 |
Beta 1 - beta 2 blocking activity of propranolol and metoprolol in the unanaesthetized genetically hypertensive and normotensive rat.
Topics: Animals; Blood Pressure; Heart Rate; Hypertension; Isoproterenol; Male; Metoprolol; Pressoreceptors; | 1984 |
Effects of phenoxybenzamine, metoprolol, captopril, and meclofenamate on cardiovascular function in deoxycorticosterone acetate hypertensive Yucatan miniature swine.
Topics: Animals; Blood Pressure; Captopril; Desoxycorticosterone; Female; Heart Rate; Hemodynamics; Hyperten | 1983 |
Effects of penbutolol and metoprolol on blood pressure, plasma catecholamines and renin activity in hypertensive patients.
Topics: Aldosterone; Blood Pressure; Catecholamines; Female; Humans; Hypertension; Male; Metoprolol; Penbuto | 1983 |
[Plasma renin activity and urinary excretion of catecholamines and their metabolites in patients with primary arterial hypertension treated with metoprolol].
Topics: Adult; Catecholamines; Epinephrine; Female; Humans; Hypertension; Male; Metoprolol; Middle Aged; Ren | 1983 |
[New aspects in the therapy of pregnancy-induced hypertension].
Topics: Anesthesia, Epidural; Epoprostenol; Female; Fenoterol; Humans; Hypertension; Labetalol; Metoprolol; | 1983 |
Effect of metoprolol on 24-hour urinary excretion of adrenal steroids and kallikrein in patients with essential hypertension.
Topics: 18-Hydroxycorticosterone; 18-Hydroxydesoxycorticosterone; Adrenal Cortex Hormones; Adult; Aldosteron | 1984 |
Effects of metoprolol and propranolol on glucose tolerance and insulin secretion in diabetes mellitus.
Topics: Adult; Aged; Blood Pressure; Diabetes Complications; Diabetes Mellitus; Double-Blind Method; Female; | 1984 |
Studies with long acting propranolol.
Topics: Angina Pectoris; Arrhythmias, Cardiac; Delayed-Action Preparations; Half-Life; Heart Rate; Humans; H | 1984 |
[Metoprolol in the treatment of hypertension].
Topics: Female; Humans; Hypertension; Male; Metoprolol; Middle Aged | 1984 |
[Effects of delayed-action metoprolol evaluated in hypertensive patients responsive to therapy subdivided in 2 different age groups].
Topics: Adult; Age Factors; Aged; Blood Pressure; Delayed-Action Preparations; Drug Evaluation; Female; Hear | 1984 |
Slow-release metoprolol, hydrochlorothiazide and hydralazine in stepwise treatment of essential hypertension.
Topics: Adolescent; Adult; Aged; Delayed-Action Preparations; Drug Combinations; Drug Evaluation; Female; Fo | 1984 |
Glucose induced paradoxical serum potassium elevation exclusively in the upright posture in metoprolol treated hypertensives.
Topics: Glucose; Humans; Hypertension; Metoprolol; Posture; Potassium | 1984 |
Effect of metoprolol in carotid sinus hypersensitive patients.
Topics: Blood Pressure; Carotid Sinus; Electrocardiography; Female; Humans; Hypertension; Male; Metoprolol; | 1984 |
Different effects of metoprolol and chlorthalidone on serum lipoprotein levels in mild hypertension. Possible implications for coronary heart disease risk status.
Topics: Body Weight; Chlorthalidone; Cholesterol; Coronary Disease; Female; Heart Rate; Humans; Hypertension | 1984 |
Hemodynamic effects of once a day administration of combined chlorthalidone and metoprolol slow-release in essential hypertension.
Topics: Administration, Oral; Blood Pressure; Chlorthalidone; Drug Therapy, Combination; Female; Heart Rate; | 1984 |
Increased cardiac output and lowered peripheral resistance during metoprolol treatment.
Topics: Adult; Blood Pressure; Capillary Resistance; Cardiac Output; Female; Heart Ventricles; Humans; Hyper | 1983 |
Disposition of the adrenergic blocker metoprolol in the late-pregnant woman, the amniotic fluid, the cord blood and the neonate.
Topics: Amniotic Fluid; Drug Therapy, Combination; Female; Fetal Blood; Humans; Hydralazine; Hypertension; I | 1984 |
Atenolol and metoprolol. A comparison of their excretion into human breast milk.
Topics: Atenolol; Female; Fetal Blood; Humans; Hypertension; Metoprolol; Milk, Human; Pregnancy; Pregnancy C | 1984 |
Effects of anti-hypertensive therapy on serum lipoproteins. Treatment with metoprolol, propranolol and hydrochlorothiazide.
Topics: Adipose Tissue; Apolipoproteins; Blood Glucose; Catecholamines; Fatty Acids; Humans; Hydrochlorothia | 1983 |
A comparative study of metoprolol and methyldopa in the treatment of hypertension.
Topics: Adult; Aged; Blood Pressure; Female; Heart Rate; Humans; Hypertension; Male; Methyldopa; Metoprolol; | 1983 |
Predictability of antihypertensive efficacy of selective beta 1 blockers.
Topics: Adult; Aldosterone; Atenolol; Blood Pressure; Cardiac Output; Catecholamines; Echocardiography; Fema | 1983 |
Bronchospasm following intraocular injection of acetylcholine in a patient taking metoprolol.
Topics: Acetylcholine; Aged; Bronchial Spasm; Cataract Extraction; Drug Interactions; Eye; Female; Humans; H | 1983 |
The use of systolic time intervals in the evaluation of antihypertensive treatment with metoprolol, labetalol and prazosin.
Topics: Adult; Aged; Ethanolamines; Female; Humans; Hypertension; Labetalol; Male; Metoprolol; Middle Aged; | 1983 |
[Effect of a metoprolol-chlorthalidone combination on arterial pressure and respiratory function].
Topics: Adult; Aged; Blood Pressure; Chlorthalidone; Drug Therapy, Combination; Female; Heart Rate; Humans; | 1983 |
Renal perfusion is preserved during cardioselective beta-blockade with metoprolol in hypertension.
Topics: Adult; Aged; Glomerular Filtration Rate; Heart Rate; Humans; Hypertension; Inulin; Male; Metoprolol; | 1984 |
Göteborg Metoprolol Trial: tolerance.
Topics: Administration, Oral; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Drug Tolerance; | 1984 |
A fixed combination of metoprolol slow-release and chlorthalidone, given once daily, in the long-term treatment of arterial hypertension.
Topics: Adult; Aged; Arteries; Chlorthalidone; Drug Therapy, Combination; Humans; Hypertension; Long-Term Ca | 1982 |
[Effects of propranolol and metoprolol on peripheral circulation in intermittent claudication].
Topics: Aged; Humans; Hypertension; Intermittent Claudication; Male; Metoprolol; Middle Aged; Propanolamines | 1983 |
[Antihypertensive effect of metoprolol in essential hypertension].
Topics: Adult; Antihypertensive Agents; Chlorthalidone; Drug Evaluation; Drug Therapy, Combination; Female; | 1983 |
Total body potassium in patients receiving chlorthalidone and metoprolol for hypertension.
Topics: Adult; Chlorthalidone; Female; Humans; Hyperkalemia; Hypertension; Male; Metoprolol; Middle Aged; Po | 1983 |
[Protection of the hypertensive patient: comparative atenolol-metoprolol study].
Topics: Adult; Atenolol; Blood Pressure; Double-Blind Method; Exercise Test; Female; Heart Rate; Humans; Hyp | 1982 |
Antihypertensive treatment inhibiting the progression of diabetic nephropathy.
Topics: Adult; Blood Pressure; Diabetic Nephropathies; Glomerular Filtration Rate; Humans; Hypertension; Mal | 1980 |
Atenolol in hypertension: follow-up of patients crossed over to this agent from propranolol, pindolol or metoprolol.
Topics: Adult; Aged; Atenolol; Drug Evaluation; Drug Therapy, Combination; Female; Follow-Up Studies; Humans | 1980 |
Newer antihypertensive agents.
Topics: Aged; Antihypertensive Agents; Captopril; Diuretics; Humans; Hypertension; Male; Metoprolol; Middle | 1980 |
Time course of blood pressure, pulse rate, plasma renin and metoprolol during treatment of hypertensive patients.
Topics: Adult; Blood Pressure; Female; Heart Rate; Humans; Hypertension; Male; Metoprolol; Middle Aged; Prop | 1980 |
A cardio-selective beta blocker (metoprolol) in hypertensive, insulin-dependent diabetics. A preliminary report.
Topics: Adult; Aged; Blood Glucose; Blood Pressure; Diabetes Mellitus; Female; Humans; Hypertension; Hypogly | 1980 |
Metoprolol in diabetes mellitus: effect on glucose homeostasis.
Topics: Aged; Blood Glucose; Diabetes Complications; Diabetes Mellitus; Female; Glucagon; Homeostasis; Human | 1980 |
[The effects of metoprolol on systolic times in patients with systemic arterial hypertension. Polygraphic study].
Topics: Adult; Female; Heart Rate; Humans; Hypertension; Male; Metoprolol; Middle Aged; Myocardial Contracti | 1982 |
[Antihypertensive treatment with metoprolol: haemodynamic reactions in hypertensives with normal left ventricular function (author's transl)].
Topics: Adult; Blood Pressure; Heart Rate; Humans; Hypertension; Male; Metoprolol; Middle Aged; Physical Exe | 1982 |
The pharmacodynamic effectiveness of metoprolol in adolescent hypertension.
Topics: Adolescent; Aerobiosis; Blood Pressure; Drug Tolerance; Exercise Test; Humans; Hypertension; Metopro | 1982 |
Relation of cardiovascular response to the hypotensive effect of metoprolol.
Topics: Adult; Blood Pressure; Cardiac Output; Drug Therapy, Combination; Female; Furosemide; Heart Rate; He | 1982 |
[Explosive diarrhea during treatment with beta blockers].
Topics: Humans; Hypertension; Male; Metoprolol; Propanolamines; Sweating | 1982 |
Effect of short-term and long-term treatment with metoprolol on renal blood flow and glomerular filtration rate in hypertensive patients with a normal kidney function.
Topics: Adult; Female; Glomerular Filtration Rate; Humans; Hypertension; Male; Metoprolol; Middle Aged; Prop | 1982 |
[Behavior of the hemorrheological pattern in subjects with essential hypertension treated with beta-blocking agents. II. Metoprolol and oxprenolol].
Topics: Adult; Blood Flow Velocity; Blood Viscosity; Female; Humans; Hypertension; Male; Metoprolol; Middle | 1982 |
[Non-invasive evaluation of some hemodynamic effects of metoprolol].
Topics: Adult; Aged; Female; Hemodynamics; Humans; Hypertension; Male; Metoprolol; Middle Aged; Propanolamin | 1981 |
[Metoprolol in the treatment of essential hypertension (author's transl)].
Topics: Adult; Female; Heart Rate; Humans; Hypertension; Male; Metoprolol; Middle Aged; Posture; Propanolami | 1981 |
[Selective beta blockaders (metoprolol) versus non selective (propranolol): comparative effects on the composition of lipoprotein fractions and on blood pressure].
Topics: Blood Pressure; Cholesterol; Double-Blind Method; Female; Humans; Hyperlipidemias; Hypertension; Lip | 1980 |
[Hypertension therapy in the aged. Possibilities and chances of success].
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Child; Drug Therapy, Combination; Female; Humans; | 1981 |
Hypertension in general practice: a comparative study of labetalol and metoprolol (+/- prazosin) in general practice.
Topics: Adult; Benzothiadiazines; Diuretics; Ethanolamines; Humans; Hypertension; Labetalol; Metoprolol; Mid | 1981 |
[Effects of metoprolol and of the combination of metoprolol and hydrochlorothiazide arterial hypertension patients].
Topics: Adult; Aged; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Met | 1980 |
[Use of metoprolol and atenolol, singly or in combination with a diuretic, in the treatment of arterial hypertension].
Topics: Adult; Atenolol; Chlorthalidone; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Meto | 1980 |
[Echocardiographic evaluation of the long-term treatment of arterial hypertension with metoprolol].
Topics: Echocardiography; Female; Hemodynamics; Humans; Hypertension; Male; Metoprolol; Myocardial Contracti | 1980 |
Disposition of metoprolol in the newborn.
Topics: Female; Humans; Hypertension; Infant, Newborn; Maternal-Fetal Exchange; Metoprolol; Pregnancy; Pregn | 1981 |
A pharmacokinetic comparison between different slow-release formulations of metoprolol (Lopresor SR and Betaloc SA)
Topics: Adult; Angina Pectoris; Delayed-Action Preparations; Humans; Hypertension; Kinetics; Metoprolol; Mid | 1981 |
Effects of treatment on circadian rhythms of blood pressure.
Topics: Antihypertensive Agents; Atenolol; Blood Pressure; Circadian Rhythm; Heart Rate; Humans; Hypertensio | 1981 |
The treatment of high blood pressure in the elderly: a multi-centre evaluation of a fixed combination of metoprolol and hydrochlorothiazide ("Co-Betaloc") in general practice.
Topics: Age Factors; Aged; Blood Pressure; Drug Combinations; Female; Heart Rate; Humans; Hydrochlorothiazid | 1981 |
Peyronie's disease.
Topics: Aged; Humans; Hypertension; Male; Metoprolol; Penile Induration; Propanolamines | 1981 |
Comparative antihypertensive effects of propranolol and metoprolol in DOC-treated rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Desoxycorticosterone; Heart Rate; Hypertension; Ma | 1981 |
[Verapamil as a hypotensive agent. Clinical, laboratory, electro- and echocardiographic study].
Topics: Adult; Aged; Chlorthalidone; Echocardiography; Electrocardiography; Female; Humans; Hypertension; Li | 1981 |
Peyronie's disease and systemic lupus erythematosus syndrome associated with metoprolol administration: a case report.
Topics: Humans; Hypertension; Lupus Erythematosus, Systemic; Male; Metoprolol; Middle Aged; Penile Induratio | 1981 |
Hypoglycemic symptoms in insulin-dependent diabetics. A prospective study of the influence of beta-blockade.
Topics: Adult; Diabetes Complications; Double-Blind Method; Female; Humans; Hypertension; Hypoglycemia; Male | 1981 |
[Evaluation of the antihypertensive effectiveness of the combination of metoprolol and chlorthalidone, using the ergometric test].
Topics: Adult; Chlorthalidone; Drug Evaluation; Drug Therapy, Combination; Exercise Test; Humans; Hypertensi | 1981 |
[Clinical and polygraphic evaluation of the effects of metoprolol and labetalol in essential arterial hypertension. Comparative study].
Topics: Adult; Ethanolamines; Female; Humans; Hypertension; Labetalol; Male; Metoprolol; Middle Aged; Propan | 1981 |
Experiences with metoprolol Durules, a slow-release formulation in hypertension.
Topics: Adult; Blood Pressure; Delayed-Action Preparations; Drug Therapy, Combination; Female; Heart Rate; H | 1980 |
[Monotherapy of uncomplicated essential hypertension with metoprolol].
Topics: Adolescent; Adult; Drug Evaluation; Female; Humans; Hypertension; Male; Metoprolol; Middle Aged; Pro | 1980 |
Long-term comparison of metoprolol and methyldopa in the treatment of hypertension.
Topics: Adult; Aged; Female; Humans; Hypertension; Male; Methyldopa; Metoprolol; Middle Aged; Propanolamines | 1980 |
Metoprolol kinetics and dose response in hypertensive patients.
Topics: Adult; Aged; Biological Availability; Blood Pressure; Dose-Response Relationship, Drug; Female; Half | 1980 |
Excessive plasma dopamine increase at rest and during exercise after long-term beta-adrenoreceptor blockade in hypertensive patients.
Topics: Adult; Blood Pressure; Dopamine; Epinephrine; Heart Rate; Humans; Hypertension; Male; Metoprolol; Mi | 1980 |
Evidences supporting an increased sympathetic tone and reactivity in a subgroup of patients with essential hypertension.
Topics: Adult; Aging; Blood Pressure; Catecholamines; Diagnosis, Differential; Epinephrine; Female; Heart Ra | 1980 |
[Effects of metoprolol on myocardial performance in hypertensive patients during exercise (author's transl)].
Topics: Adult; Exercise Test; Female; Humans; Hypertension; Male; Metoprolol; Middle Aged; Myocardium; Propa | 1980 |
Nicardipine may impair glucose metabolism in hypertensive diabetic patients.
Topics: Adult; Aged; Atenolol; Carteolol; Diabetes Mellitus, Type 2; Diltiazem; Enalapril; Female; Glucose; | 1994 |
Elevated plasma atrial natriuretic peptide concentrations in hypertensive patients with acute myocardial infarction.
Topics: Acebutolol; Adult; Aged; Atrial Natriuretic Factor; Blood Pressure; Cardiac Output, Low; Creatine Ki | 1995 |
Metoprolol for action tremor following intracerebral hemorrhage.
Topics: Activities of Daily Living; Adult; Cerebral Hemorrhage; Cerebral Infarction; Drug Monitoring; Humans | 1994 |
Time-dependent efficacy of antihypertensive agents in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Captopril; Circadian Rhythm; Clonidine; Felodipine | 1993 |
Enhancement of GABAergic system activity by metoprolol in spontaneously hypertensive rats.
Topics: Analysis of Variance; Animals; Blood Pressure; Brain; Corpus Striatum; Dihydralazine; gamma-Aminobut | 1993 |
Ten year mortality in relation to original size of myocardial infarct: results from the Gothenburg metoprolol study.
Topics: Adult; Aged; Angina Pectoris; Diabetes Complications; Female; Follow-Up Studies; Humans; Hypertensio | 1994 |
Aortic dissection due to discontinuation of beta-blocker therapy.
Topics: Aortic Aneurysm, Thoracic; Aortic Dissection; Blood Vessel Prosthesis; Hemodynamics; Humans; Hyperte | 1993 |
Effects of long-term antihypertensive treatment and aging on renal function and albumin excretion in primary hypertension.
Topics: Aging; Albuminuria; Case-Control Studies; Drug Therapy, Combination; Follow-Up Studies; Glomerular F | 1993 |
[Decreasing the antihypertensive dosage during longterm treatment and complete regression of left ventricular hypertrophy].
Topics: Adult; Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Echocardiography; Exercis | 1996 |
Effects of antihypertensive therapy on platelet cytosolic calcium responses to low density lipoprotein cholesterol.
Topics: Aged; Aged, 80 and over; Blood Platelets; Calcium; Cholesterol, LDL; Cytosol; Diltiazem; Drug Therap | 1996 |
Xerostomia: prevalence and pharmacotherapy. With special reference to beta-adrenoceptor antagonists.
Topics: Adrenergic beta-Antagonists; Adult; Age Factors; Aged; Aged, 80 and over; Amylases; Antihypertensive | 1996 |
Effects on salivary flow rate and composition of withdrawal of and re-exposure to the beta 1-selective antagonist metoprolol in a hypertensive patient population.
Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-Antagonists; Amylases; Antihypertensive Agen | 1996 |
Daily exercise and gender influence postexercise cardiac autonomic responses in hypertensive rats.
Topics: Animals; Atropine Derivatives; Autonomic Nervous System; Exercise Test; Female; Heart; Heart Rate; H | 1997 |
Cardiovascular and renal effects of the combination of felodipine and metoprolol during a high-salt and a moderate-salt diet in spontaneously hypertensive rats.
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Calcium Channel Blockers; Drug Therapy, Combin | 1997 |
Circadian and ultradian control of cardiac output in spontaneous hypertension in rats.
Topics: Activity Cycles; Animals; Atropine Derivatives; Blood Pressure; Cardiac Output; Circadian Rhythm; He | 1997 |
Differences between the effects of metoprolol and prazosin on the forearm vasculature in primary hypertension.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Catecholamines; Female; Forearm; H | 1997 |
[Intraoperative diagnosis of a multilocal pheochromocytoma].
Topics: Adrenal Gland Neoplasms; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aged; Anesthesia | 1997 |
Pheochromocytoma crisis caused by contemporary ergotamine, caffeine, and nimesulide administration.
Topics: Adrenal Gland Neoplasms; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; A | 1997 |
Treatment of milrinone-associated tachycardia with beta-blockers.
Topics: Adrenergic beta-Antagonists; Aged; Anesthesia, Epidural; Anesthesia, General; Anti-Arrhythmia Agents | 1998 |
Acute exercise and gender alter cardiac autonomic tonus differently in hypertensive and normotensive rats.
Topics: Adrenergic alpha-Antagonists; Animals; Autonomic Nervous System; Blood Pressure; Female; Heart; Hear | 1998 |
An unusual toxic reaction to axillary block by mepivacaine with adrenaline.
Topics: Absorption; Aged; Akathisia, Drug-Induced; Anesthetics, Local; Anti-Arrhythmia Agents; Antihypertens | 1998 |
Concentration-effect relationship of l-propranolol and metoprolol in spontaneous hypertensive rats after exercise-induced tachycardia.
Topics: Adrenergic beta-Antagonists; Animals; Blood Proteins; Dose-Response Relationship, Drug; Heart Rate; | 1998 |
Beta adrenergic blockers lower renin in patients treated with ACE inhibitors and diuretics.
Topics: Adrenergic beta-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Atenolol; Bisoprolol; C | 1998 |
Cost-effectiveness of felodipine-metoprolol (Logimax) and enalapril in the treatment of hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Cost-Benefit Analysis; Drug Combinations; Enalapril; Felodipin | 1998 |
Pharmacokinetic-pharmacodynamic modeling of metoprolol stereoisomers in spontaneously hypertensive rat.
Topics: Adrenergic beta-Antagonists; Animals; Area Under Curve; Blood Pressure; Heart Rate; Hypertension; Ma | 1997 |
Cost-effectiveness of antihypertensive treatment: metoprolol versus thiazide diuretics.
Topics: Benzothiadiazines; Cost-Benefit Analysis; Diuretics; Humans; Hypertension; Life Expectancy; Male; Me | 1993 |
The beta2-adrenergic modulator celiprolol reduces insulin resistance in obese Zucker rats.
Topics: Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Biological Transport, Active; Blood G | 1999 |
One doctor's 25-year experience of beta-blocker treatment to the same group of hypertensive women.
Topics: Adrenergic beta-Antagonists; Adult; Alprenolol; Antihypertensive Agents; Body Weight; Continuity of | 1999 |
Coronary revascularization and aggressive lipid lowering.
Topics: Aspirin; Atorvastatin; Coronary Stenosis; Heptanoic Acids; Humans; Hyperlipidemias; Hypertension; Hy | 1999 |
Disparate effects of carvedilol versus metoprolol treatment of stroke-prone spontaneously hypertensive rats on endothelial function of resistance arteries.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Carbazoles; Carvedilol; Endothelium, | 2000 |
Side effects of beta-blocker treatment for hypertension.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Arrhythmias, Cardiac; Dizziness; Female; Heada | 2000 |
Anti beta1-adrenoceptor autoantibodies analyzed in spontaneously beating neonatal rat heart myocyte cultures-comparison of methods.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Animals, Newborn; Autoantibodies; Bi | 2001 |
Once-daily treatment of hypertension.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Atenolol; Hypertension; Metoprolol; Pindolol; | 1976 |
Plasma renin activity vs. concentration.
Topics: Adrenergic beta-Antagonists; Atenolol; Humans; Hypertension; Metoprolol; Renin | 1976 |
Beta-adrenergic receptor blocking drugs in spontaneous hypertension.
Topics: Adrenergic beta-Antagonists; Aging; Alprenolol; Animals; Blood Pressure; Hypertension; Male; Metopro | 1976 |
Acute hypotensive effect of combined beta1-adrenoceptor blockade and beta2-adrenoceptor stimulation in spontaneously hypertensive rats (SHR).
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Depression, Chemical | 1977 |
Antihypertensive effect and tolerability of metoprolol during long-term treatment: a multicentre study.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Alanine Transaminase; Aspartate Aminotransferases; Blood P | 1977 |
[Effects of kitchen salt and beta sympatholytics on the course of blood pressure in the hereditary, spontaneously hypertensive rat (SH rats, Münster strain)].
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Disease Models, Animal; Hypertension; Metoprol | 1977 |
alpha-Methyldopa and beta-blockers in hypertension--a comparison of their haemodynamic effects.
Topics: Adrenergic beta-Antagonists; Alprenolol; Hemodynamics; Humans; Hypertension; Methyldopa; Metoprolol; | 1978 |
Prevention and reversal of isolation-induced systolic arterial hypertension in rats by treatment with beta-adrenoceptor antagonists.
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Heart Rate; Hypertension; Male; Metoprolol; Proprano | 1979 |
[The effect of so-called cardioselective and non-cardioselective beta-receptor blockers on the metabolism during ergometric exercise in hypertensive patients].
Topics: Adrenergic beta-Antagonists; Adult; Carbohydrate Metabolism; Humans; Hypertension; Lipid Metabolism; | 1978 |
Vasospastic phenomena in patients treated with beta-adrenoceptor blocking agents.
Topics: Adrenergic beta-Antagonists; Alprenolol; Blood Circulation; Cardiac Output; Female; Humans; Hyperten | 1979 |
Negative consequences of blood pressure reduction. The effect of sympathetic inhibition on plasma levels of catecholamines, growth hormone, glucagon and cortisol.
Topics: Adrenergic beta-Antagonists; Blood Glucose; Catecholamines; Glucagon; Growth Hormone; Humans; Hydroc | 1979 |
Effects of beta-adrenoreceptor antagonists on sino-aortic baroreflex sensitivity and blood pressure in hypertensive man.
Topics: Acebutolol; Adolescent; Adrenergic beta-Agonists; Adult; Aging; Blood Pressure; Female; Heart Rate; | 1979 |
Dangerous antihypertensive treatment.
Topics: Adrenergic beta-Antagonists; Diuretics; Drug Combinations; Humans; Hydrochlorothiazide; Hypertension | 1979 |
Beta-blocker withdrawal syndrome.
Topics: Aged; Female; Humans; Hypertension; Hypotension, Orthostatic; Metoprolol; Propanolamines; Substance | 1979 |
Influence of once-daily administration of beta-adrenoceptor antagonists on arterial pressure and its variability.
Topics: Acebutolol; Activities of Daily Living; Adolescent; Adult; Bed Rest; Blood Pressure; Circadian Rhyth | 1979 |
Influence of beta blockade on the renin-angiotensin-aldosterone system [proceedings].
Topics: Aldosterone; Angiotensin II; Humans; Hypertension; Metoprolol; Propanolamines; Propranolol; Renin | 1979 |
Effects of salbutamol and metoprolol on plasma renin activity and plasma potassium of normal subjects and of hypertensive patients.
Topics: Adolescent; Adult; Albuterol; Female; Hemodynamics; Humans; Hyperaldosteronism; Hypertension; Male; | 1978 |
Influence of selective and non-selective beta-adrenoreceptor blockade on the haemodynamic effect of adrenaline during combined antihypertensive drug therapy.
Topics: Adult; Blood Pressure; Epinephrine; Heart Rate; Humans; Hypertension; Metoprolol; Middle Aged; Propa | 1979 |
Drugs in current use: metoprolol.
Topics: Adult; Aged; Angina Pectoris; Child; Female; Humans; Hypertension; Metoprolol; Pregnancy; Propanolam | 1979 |
Pathophysiological mechanisms of the antihypertensive effect of a cardioselective beta-adrenoceptor blocking drug (metoprolol).
Topics: Aldosterone; Cardiac Output; Hemodynamics; Humans; Hypertension; Kidney; Male; Metoprolol; Middle Ag | 1979 |
Effects of metoprolol on adrenergic mechanisms during long- and short-term antihypertensive treatment of spontaneously hypertensive rats.
Topics: Animals; Female; Hemodynamics; Hypertension; Metoprolol; Propanolamines; Rats; Receptors, Adrenergic | 1979 |
The first year of metroprolol (Lopresor): an analysis of a newly released drug in general practice.
Topics: Adult; Aged; Female; Humans; Hypertension; Male; Metoprolol; Middle Aged; Propanolamines | 1979 |
Long-term experiences with minoxidil in combination treatment of severe arterial hypertension.
Topics: Adult; Aged; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Hydroflumethiazide; Hyperte | 1977 |
[Studies on the antihypertensive effect of metoprolol in practice. Results of a cooperative study by 1296 general practitioners (author's transl)].
Topics: Adolescent; Adult; Aged; Blood Pressure; Child; Drug Tolerance; Family Practice; Female; Humans; Hyp | 1978 |
Angiotensin II blockade during combined thiazide-beta-adrenoreceptor-blocker treatment.
Topics: Adult; Angiotensin II; Atenolol; Blood Pressure; Female; Humans; Hydrochlorothiazide; Hypertension; | 1979 |
[Short-term effects of a treatment with methoprolol (a selective beta 1-blocking agent) in essential hypertension. Changes of haemodynamics, renin, aldosterone, sodium and potassium balance (author's transl)].
Topics: Adult; Aldosterone; Drug Evaluation; Female; Hemodynamics; Humans; Hypertension; Male; Metoprolol; M | 1979 |
[Hypertension therapy with metoprolol--comparison between single and double doses].
Topics: Adult; Aged; Dose-Response Relationship, Drug; Drug Evaluation; Female; Humans; Hypertension; Male; | 1979 |
Drug treatment of essential hypertension. Practical guidelines.
Topics: Adult; Aged; Chlorthalidone; Drug Therapy, Combination; Female; Humans; Hydralazine; Hypertension; M | 1979 |
Effects of metoprolol on blood pressure and plasma renin activity in thiazide-resistant hypertensive patients.
Topics: Adult; Blood Pressure; Creatinine; Drug Resistance; Female; Heart Rate; Humans; Hydrochlorothiazide; | 1979 |
The use of metoprolol in the management of hypertension.
Topics: Adolescent; Adult; Blood Pressure; Female; Humans; Hypertension; Male; Metoprolol; Middle Aged; Post | 1979 |
Protein synthesis and composition of cardiac and vascular tissue in spontaneously hypertensive rats and the effects of beta-adrenergic antagonist treatment.
Topics: Animals; Heart; Hypertension; Hypertrophy; Male; Metoprolol; Muscle Proteins; Muscle, Smooth, Vascul | 1979 |
A fixed combination of metoprolol and hydrochlorothiazide for hypertension: a multi-centre study.
Topics: Adult; Blood Pressure; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Male; M | 1979 |
[Experiences from long-term treatment of hypertension with metoprolol].
Topics: Adult; Aged; Drug Evaluation; Female; Humans; Hypertension; Male; Metoprolol; Middle Aged; Propanola | 1978 |
Effect of metoprolol on blood glycerol, free fatty acids, triglycerides and glucose in relation to plasma catecholamines in hypertensive patients at rest and following submaximal work.
Topics: Blood Glucose; Catecholamines; Fatty Acids, Nonesterified; Glycerol; Humans; Hypertension; Male; Met | 1978 |
Relative significance of plasma renin activity and concentration in physiologic and pathophysiologic conditions.
Topics: Adult; Age Factors; Aged; Aldosterone; Angiotensin II; Diet; Diet, Sodium-Restricted; Female; Humans | 1978 |
Comparison of intra-arterial and indirect blood pressures at rest and during isometric exercise in hypertensive patients before and after metoprolol.
Topics: Adult; Blood Pressure; Female; Heart Rate; Humans; Hypertension; Metoprolol; Middle Aged; Physical E | 1978 |
Blood-pressure control round the clock.
Topics: Atenolol; Humans; Hypertension; Metoprolol; Time Factors | 1978 |
Relative activity of atenolol and metoprolol.
Topics: Atenolol; Heart Rate; Humans; Hypertension; Metoprolol; Physical Exertion; Propanolamines; Research | 1978 |
An open study of the antihypertensive efficacy of metoprolol.
Topics: Adult; Aged; Female; Humans; Hypertension; Male; Metoprolol; Middle Aged; Placebos; Propanolamines; | 1978 |
Antihypertensive treatment with the adrenergic beta-receptor blocker metoprolol during pregnancy.
Topics: Apgar Score; Drug Evaluation; Drug Therapy, Combination; Female; Fetal Growth Retardation; Fetus; Hu | 1978 |
Acute haemodynamic effects of metoprolol in hypertensive patients.
Topics: Adult; Blood Pressure; Female; Heart Rate; Hemodynamics; Humans; Hypertension; Male; Metoprolol; Oxy | 1977 |
[Metoprolol in essential arterial hypertension].
Topics: Adult; Aldosterone; Diet; Drug Evaluation; Female; Humans; Hypertension; Male; Metoprolol; Middle Ag | 1977 |
Haemodynamic long-term effects of metoprolol at rest and during exercise in essential hypertension.
Topics: Adult; Blood Pressure; Cardiac Output; Heart Rate; Hemodynamics; Humans; Hypertension; Male; Metopro | 1977 |
Cerebrospinal fluid concentration of metoprolol in a hypertensive patient.
Topics: Chromatography, Gas; Female; Humans; Hypertension; Metoprolol; Middle Aged; Propanolamines | 1977 |
Plasma metoprolol concentrations in young, old and hypertensive subjects.
Topics: Adult; Aged; Aging; Blood Urea Nitrogen; Creatinine; Female; Humans; Hypertension; Male; Metoprolol; | 1977 |
Plasma levels and effect on heart rate and blood pressure of metoprolol after acute oral administration in 12 geriatric patients.
Topics: Administration, Oral; Age Factors; Aged; Blood Pressure; Drug Evaluation; Female; Half-Life; Heart R | 1976 |
Studies with a new cardioselective beta-blocker, metoprolol.
Topics: Adult; Blood Pressure; Blood Vessels; Bronchi; Epinephrine; Hemodynamics; Humans; Hypertension; Meto | 1976 |
Anti-hypertensive effect of metoprolol in spontaneously hypertensive rats.
Topics: Animals; Female; Heart Rate; Hypertension; Metoprolol; Propanolamines; Rats; Time Factors; Vasomotor | 1976 |
Hemodynamic and reflex sympathetic control of transmural activation and rate of ventricular tachycardia in ischemic and hypertrophic ventricular myocardium of the dog.
Topics: Adrenergic beta-Antagonists; Animals; Autonomic Nervous System; Cardiac Pacing, Artificial; Cardiome | 1992 |
[The action of the new beta-adrenoblocker Lopressor on the hemodynamics of hypertension patients].
Topics: Adult; Drug Evaluation; Hemodynamics; Humans; Hypertension; Metoprolol; Middle Aged; Propranolol; Ta | 1992 |
[The effect of acebutolol and metoprolol on noninvasive ambulatory blood pressure monitoring system in essential hypertension].
Topics: Acebutolol; Adult; Aged; Blood Pressure; Blood Pressure Monitors; Circadian Rhythm; Female; Humans; | 1992 |
Betablocking drugs in essential hypertension: transdermal bupranolol compared with oral metoprolol.
Topics: Administration, Cutaneous; Administration, Oral; Adult; Blood Pressure; Bupranolol; Cholesterol; Dru | 1992 |
Use of beta-blockade in a patient with phaeochromocytoma and asthma.
Topics: Adrenal Gland Neoplasms; Adult; Asthma; Female; Humans; Hypertension; Metoprolol; Pheochromocytoma; | 1992 |
Effects of chronic felodipine treatment on renal function and morphology in SHR.
Topics: Animals; Blood Pressure; Creatinine; Drug Synergism; Felodipine; Female; Glomerulosclerosis, Focal S | 1992 |
ACE-inhibition and renoprotection in early diabetic nephropathy. Response to enalapril acutely and in long-term combination with conventional antihypertensive treatment.
Topics: Adult; Albuminuria; Blood Pressure; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Drug Therapy, | 1991 |
Acute effects of combined alpha/beta-adrenoceptor blockade v combined beta-receptor and slow channel calcium blockade in ischemic heart disease complicated by hypertension. Hemodynamic and adrenergic responses.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Calcium Channel Blockers; Cardiac Output; | 1991 |
Modification of circadian blood pressure and heart rate variability by five different antihypertensive agents in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Captopril; Circadian Rhythm; Clonidine; Heart Rate | 1991 |
Comparison of the effects of nicardipine and metoprolol on lipid and glycidic metabolism in hypertensive subjects.
Topics: Aged; Blood Glucose; Female; Glucose; Humans; Hypertension; Insulin; Lipid Metabolism; Male; Metopro | 1991 |
Reducing pulse pressure in hypertension may normalize small artery structure.
Topics: Animals; Antihypertensive Agents; Arteries; Blood Pressure; Captopril; Dihydropyridines; Heart Rate; | 1991 |
The effect of metoprolol on left ventricular systolic and diastolic function in essential hypertension.
Topics: Adult; Aged; Cardiomegaly; Delayed-Action Preparations; Diastole; Echocardiography; Electrocardiogra | 1991 |
Exaggerated sympathetic nervous system response to extended psychological stress in offspring of hypertensives.
Topics: Adult; Blood Pressure; Blood Volume; Forearm; Heart Rate; Humans; Hypertension; Male; Metoprolol; Mi | 1991 |
Metoprolol as antihypertensive drug.
Topics: Humans; Hypertension; Lipid Metabolism; Metoprolol; Monitoring, Physiologic; Nitrendipine | 1991 |
Effects of beta blockade on the relation between heart rate and ventricular diastolic perfusion time during exercise in systemic hypertension.
Topics: Blood Pressure; Diastole; Female; Heart Rate; Humans; Hypertension; Male; Metoprolol; Middle Aged; P | 1991 |
Incidence of sudden cardiac death associated with coronary artery occlusion in dogs with hypertension and left ventricular hypertrophy is reduced by chronic beta-adrenergic blockade.
Topics: Adrenergic beta-Antagonists; Animals; Cardiomegaly; Coronary Circulation; Coronary Disease; Death, S | 1990 |
[Acute changes of coronary and global hemodynamics in patients with angina pectoris and arterial hypertension caused by celiprolol and metoprolol].
Topics: Adrenergic beta-Antagonists; Adult; Angina Pectoris; Celiprolol; Hemodynamics; Humans; Hypertension; | 1990 |
Significance of coronary circulation in hypertensive heart disease for development and prevention of heart failure.
Topics: Adult; Animals; Cardiac Output, Low; Cardiomegaly; Coronary Circulation; Coronary Disease; Coronary | 1990 |
Free radical generation, lipid peroxidation and essential fatty acids in uncontrolled essential hypertension.
Topics: Angiotensin II; Antihypertensive Agents; Endothelium, Vascular; Epoprostenol; Fatty Acids, Essential | 1990 |
Acute and steady-state pharmacokinetics and antihypertensive effects of felodipine in patients with normal and impaired renal function.
Topics: Adult; Aged; Biological Availability; Blood Pressure; Felodipine; Female; Furosemide; Glomerular Fil | 1990 |
Nephropathy in model combining genetic hypertension with experimental diabetes. Enalapril versus hydralazine and metoprolol therapy.
Topics: Administration, Oral; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Diabetes Melli | 1990 |
A pressor effect of noncardioselective beta-blockers in mildly hypertensive patients during acute hospitalization.
Topics: Adult; Aged; Aged, 80 and over; Atenolol; Blood Pressure; Echocardiography; Female; Heart Rate; Hosp | 1990 |
Betaloc therapy in pregnancy-associated mild and moderately severe hypertension.
Topics: Adolescent; Adult; Blood Pressure; Female; Heart Rate; Heart Rate, Fetal; Humans; Hypertension; Infa | 1990 |
Safety and tolerability of metoprolol OROS in hypertension treatment.
Topics: Administration, Oral; Adult; Blood Pressure; Delayed-Action Preparations; Humans; Hypertension; Male | 1990 |
[The effect of OROS metoprolol in mild and moderately severe essential hypertension].
Topics: Adult; Aged; Blood Pressure; Female; Heart Rate; Humans; Hypertension; Male; Metoprolol; Middle Aged | 1990 |
[Non-invasive long-term monitoring of blood pressure and arrhythmias in hypertensive patients treated with metoprolol].
Topics: Adult; Aged; Blood Pressure; Blood Pressure Determination; Cardiac Complexes, Premature; Electrocard | 1988 |
Baroreflex control of heart rate and renin release in SHR following administration of felodipine, an antihypertensive Ca2+ antagonist.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Felodipine; Heart Rate; Hypertension; Metoprolol; | 1987 |
Antihypertensive treatment in elderly hypertensives: implications of the MEHP study.
Topics: Aged; Aging; Antihypertensive Agents; Blood Pressure; Humans; Hypertension; Metoprolol; Middle Aged; | 1987 |
Do beta-blockers alter lipids and what are the consequences?
Topics: Adrenergic beta-Antagonists; Blood Pressure; Chlorthalidone; Diuretics; Female; Humans; Hypertension | 1987 |
Regression of left ventricular mass is accompanied by improvement in rapid left ventricular filling following antihypertensive therapy with metoprolol.
Topics: Adult; Blood Pressure; Cardiomegaly; Echocardiography; Female; Heart; Heart Rate; Humans; Hypertensi | 1989 |
Development of blood pressure in spontaneously hypertensive rats after withdrawal of long-term treatment related to vascular structure.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Captopril; Hydralazine; Hypertension; Indoles; Isr | 1989 |
[Long-term treatment of hypertension with a selective beta-1-blockader without sympathomimetic activity. II. Changes in the structure and function of the left ventricle].
Topics: Cardiomegaly; Diastole; Drug Evaluation; Heart; Heart Ventricles; Humans; Hypertension; Metoprolol; | 1989 |
Effects of cilazapril on hypertension, sleep, and apnea.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Cilazapril; Double-Blind Meth | 1989 |
Enalapril retards glomerular basement membrane thickening and albuminuria in the diabetic rat: are these effects specific for enalapril?
Topics: Albuminuria; Animals; Basement Membrane; Blood Pressure; Diabetes Mellitus, Experimental; Diabetic N | 1989 |
[Metoprolol and metipranolol in the treatment of hypertension-- comparison of the effects of a single dose and administration for 1 month].
Topics: Blood Pressure; Drug Administration Schedule; Drug Therapy, Combination; Humans; Hypertension; Male; | 1989 |
MAPHY and the two arms of HAPPHY.
Topics: Adrenergic beta-Antagonists; Arteriosclerosis; Benzothiadiazines; Coronary Disease; Diuretics; Human | 1989 |
[The treatment of essential hypertension in the hospital and in the office: is there a difference?].
Topics: Drug Therapy, Combination; Family Practice; Heart Rate; Humans; Hypertension; Institutional Practice | 1989 |
Haemodynamic effects and pharmacokinetics of felodipine at rest and during exercise in hypertensive patients treated with metoprolol or atenolol.
Topics: Aged; Atenolol; Blood Pressure; Calcium Channel Blockers; Exercise; Exercise Test; Felodipine; Femal | 1989 |
Effect of metoprolol on plasma lipids and arterial intimal lipid deposition in spontaneously hypertensive rats.
Topics: Animals; Aorta; Arteriosclerosis; Coronary Vessels; Diet, Atherogenic; Hypertension; Lipids; Male; M | 1989 |
Effect of metoprolol on serial measurements of exchangeable sodium, blood pressure, renin and pulse rate in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Creatinine; Eating; Hypertension; Male; Metoprolol; Pulse; Rats; Rats, Inbr | 1989 |
Converting enzyme-inhibition in diabetic nephropathy.
Topics: Albuminuria; Blood Pressure; Captopril; Diabetic Nephropathies; Drug Therapy, Combination; Furosemid | 1989 |
The relationship between casual and ambulatory blood pressure in essential hypertension: the influence of work, duration of hypertension and antihypertensive treatment.
Topics: Adult; Aged; Blood Pressure; Blood Pressure Determination; Circadian Rhythm; Female; Humans; Hyperte | 1989 |
Mechanism of antihypertensive action of dilevalol compared with that of "cardioselective" beta-blocking agents.
Topics: Adult; Aged; Atenolol; Female; Heart; Heart Rate; Humans; Hypertension; Labetalol; Male; Metoprolol; | 1989 |
Adrenergic blocking agents and lipoprotein lipase activity.
Topics: Adult; Blood Pressure; Cholesterol; Cholesterol, HDL; Enzyme Activation; Female; Heart Rate; Humans; | 1989 |
Efficacy of a new antihypertensive agent (indenolol) assessed by ambulatory blood pressure monitoring.
Topics: Adrenergic beta-Antagonists; Ambulatory Care; Blood Pressure Determination; Humans; Hypertension; In | 1985 |
Weight reduction in hypertension.
Topics: Humans; Hypertension; Metoprolol; Obesity | 1985 |
Side-effects of beta-blockers assessed using visual analogue scales.
Topics: Acebutolol; Adrenergic beta-Antagonists; Analysis of Variance; Atenolol; Dreams; Fatigue; Humans; Hy | 1985 |
A comparison of the pharmacokinetics of atenolol, metoprolol, oxprenolol and propranolol in elderly hypertensive and young healthy subjects.
Topics: Adrenergic beta-Antagonists; Adult; Age Factors; Aged; Atenolol; Blood Proteins; Female; Half-Life; | 1985 |
Antihypertensive activity of a new vasodilator, cadralazine, administered alone or in combination with a beta-blocker.
Topics: Adrenergic beta-Antagonists; Adult; Antihypertensive Agents; Blood Pressure; Drug Therapy, Combinati | 1985 |
[Effect of 3-month treatment with propranolol, oxprenolol, metoprolol and pindolol on plasma lipids and lipoproteins in patients with primary arterial hypertension].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Female; Humans; Hypertension; Lipids; Male; Metoprolol; Mi | 1985 |
[Regression of myocardial hypertrophy in hypertensives on chronic beta-receptor block].
Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Carbazoles; Cardiomegaly; Carvedilol; Chronic Di | 1986 |
Antihypertensive effects of 12 beta adrenoceptor antagonists in conscious spontaneously hypertensive rats: relationship to changes in plasma renin activity, heart rate and sympathetic nerve function.
Topics: Acebutolol; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Blood Pressure; Decerebrate St | 1986 |
Debrisoquine polymorphism and the metabolism and action of metoprolol, timolol, propranolol and atenolol.
Topics: Adrenergic beta-Antagonists; Adult; Atenolol; Debrisoquin; Genetic Variation; Humans; Hypertension; | 1986 |
[Cardiovascular response to isometric exercise test during beta blocker and diuretic treatment in essential arterial hypertension].
Topics: Adrenergic beta-Antagonists; Adult; Atenolol; Blood Pressure; Chlorthalidone; Diuretics; Drug Evalua | 1988 |
Bradycardia induced by an interaction between phenelzine and beta blockers.
Topics: Aged; Angina Pectoris; Bradycardia; Depressive Disorder; Drug Interactions; Drug Therapy, Combinatio | 1989 |
[Several cardiovascular manifestations induced by vibrational stimuli].
Topics: Adult; Autonomic Nervous System Diseases; Cardiovascular Diseases; Fingers; Humans; Hypertension; Me | 1985 |
Long-term effect of antihypertensive therapy on left ventricular hypertrophy.
Topics: Adult; Antihypertensive Agents; Atenolol; Cardiomegaly; Drug Therapy, Combination; Echocardiography; | 1987 |
Long-term beta 1-selective adrenergic blockade and adrenergic receptors in human subcutaneous adipocytes.
Topics: Adipose Tissue; Adult; Blood Pressure; Catecholamines; Female; Heart Rate; Humans; Hypertension; Lip | 1985 |
[Hypotensive effect of ketanserin and evaluation of its alpha-blocking activity].
Topics: Adult; Double-Blind Method; Female; Heart Rate; Humans; Hypertension; Ketanserin; Male; Metoprolol; | 1986 |
Atrial natriuretic peptide and the natriuresis due to acute beta-blockade in conscious hypertensive rats.
Topics: Animals; Atrial Natriuretic Factor; Hypertension; Male; Metoprolol; Natriuresis; Rats; Rats, Inbred | 1987 |
A comparison of the effects of combined or separate alpha- and beta-blockade in the treatment of hypertension in the acute stage of myocardial infarction.
Topics: Adult; Aged; Blood Pressure; Carbon Dioxide; Female; Heart Rate; Humans; Hypertension; Infusions, Pa | 1986 |
Acute haemodynamic effect of metoprolol in essential hypertension.
Topics: Adolescent; Adult; Blood Pressure; Cardiac Output; Female; Forearm; Heart Rate; Hemodynamics; Humans | 1988 |
The effect of hydralazine on steady-state plasma concentrations of metoprolol in pregnant hypertensive women.
Topics: Adult; Drug Interactions; Drug Therapy, Combination; Female; Humans; Hydralazine; Hypertension; Meto | 1988 |
[Systolic pressure--left-ventricular telesystolic volume ratio in the treatment of hypertension with a cardioselective beta-blockader without inner sympathomimetic activity].
Topics: Adult; Blood Pressure; Cardiac Volume; Female; Heart Ventricles; Humans; Hypertension; Male; Metopro | 1988 |
The effects of combining felodipine and metoprolol in moderate to severe hypertension--a one year study.
Topics: Adult; Aged; Antihypertensive Agents; Drug Therapy, Combination; Felodipine; Female; Humans; Hyperte | 1988 |
Sympathetic and parasympathetic influence on blood pressure and heart rate variability in Wistar-Kyoto and spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Circadian Rhythm; Heart Rate; Hypertension; Metoprolol; N-Methylscopolamine | 1988 |
Studies on the mechanism of metoprolol in high adrenergic drive conditions after exercise in hypertension.
Topics: Blood Pressure; Echocardiography; Energy Metabolism; Exercise Test; Female; Heart Rate; Humans; Hype | 1988 |
Effects of felodipine and metoprolol on blood pressure, plasma renin, angiotensin II, aldosterone and catecholamines in hypertensive patients.
Topics: Adult; Aldosterone; Angiotensin II; Antihypertensive Agents; Blood Pressure; Catecholamines; Electro | 1987 |
A general-practice study of the efficacy and tolerability of metoprolol in mild essential hypertension.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Pressure; Dose-Response Relationship, Drug; Drug E | 1988 |
Influence of antihypertensive treatment on basal cerebral arteries in spontaneously hypertensive rats. A morphometric study.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cerebral Arteries; Drug Therapy, Combination; Felo | 1988 |
Metoprolol and hydrochlorothiazide in the treatment of elderly hypertensive patients. A Dutch multicentre trial. The Dutch Investigators Group for the Study of Antihypertensive Treatment in the Elderly.
Topics: Aged; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertens | 1988 |
Cardiovascular and renal effects of long-term antihypertensive treatment.
Topics: Drug Therapy, Combination; Echocardiography; Follow-Up Studies; Hemodynamics; Humans; Hypertension; | 1988 |
[Changes in plasma lipid fractions during long-term treatment of arterial hypertension with metoprolol (Betaloc-Astra)].
Topics: Adult; Aged; Antihypertensive Agents; Female; Humans; Hypertension; Lipids; Male; Metoprolol; Middle | 1988 |
Antihypertensive drug treatment and the left ventricle.
Topics: Adult; Aged; Antihypertensive Agents; Diuretics; Echocardiography; Female; Heart; Humans; Hypertensi | 1987 |
Disposition of the adrenergic blocker metoprolol and its metabolite OH-metoprolol in maternal plasma, amniotic fluid and capillary blood of the neonate.
Topics: Amniotic Fluid; Capillaries; Female; Half-Life; Humans; Hypertension; Infant, Newborn; Male; Metopro | 1987 |
Observations with metoprolol in elderly patients.
Topics: Adult; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Female; Humans; Hypertension; Male; Metoprolol | 1987 |
Structural and functional adaptations within the myocardium and coronary vessels after antihypertensive therapy in spontaneously hypertensive rats.
Topics: Animals; Coronary Circulation; Coronary Vessels; Felodipine; Hypertension; Metoprolol; Myocardium; N | 1986 |
Does sympathectomy or antihypertensive treatment affect the morphometry of basal cerebral arteries in spontaneously hypertensive rats?
Topics: Age Factors; Animals; Blood Pressure; Cerebral Arteries; Felodipine; Ganglia, Sympathetic; Hypertens | 1986 |
Reactivity to mental stress and cold provocation during long-term treatment with metoprolol, propranolol or hydrochlorothiazide.
Topics: Adult; Blood Pressure; Catecholamines; Cold Temperature; Humans; Hydrochlorothiazide; Hypertension; | 1986 |
Acute haemodynamic and humoral responses to felodipine and metoprolol in mild hypertension.
Topics: Adult; Aldosterone; Antihypertensive Agents; Calcium Channel Blockers; Catecholamines; Drug Therapy, | 1987 |
[Hypokalemic rhabdomyolysis associated with diuretic and beta blockader therapy].
Topics: Chlorthalidone; Drug Therapy, Combination; Female; Humans; Hypertension; Hypokalemia; Metoprolol; Mi | 1987 |
Role of the sympathetic nervous system in the pathophysiology of cardiovascular disease.
Topics: Drug Evaluation; Humans; Hypertension; Metoprolol; Psychophysiology; Sympathetic Nervous System; Typ | 1987 |
The use of Doppler echocardiography to assess the acute haemodynamic response to felodipine and metoprolol in hypertensive patients.
Topics: Adult; Antihypertensive Agents; Cardiac Output; Echocardiography; Felodipine; Hemodynamics; Humans; | 1987 |
The role of antihypertensive pharmacologic treatment in countering adverse pathophysiological profiles: influence on small arteries.
Topics: Adaptation, Biological; Animals; Antihypertensive Agents; Arteries; Arterioles; Cats; Forearm; Human | 1987 |
Increase of renal sympathetic nerve activity by metoprolol or propranolol in conscious spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Heart Rate; Hypertension; Kidney; Male; Metoprolol; Pressoreceptors; Propra | 1987 |
The influence of antihypertensive treatment on the renal arterial structure in spontaneously hypertensive rats. A morphometric study.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Felodipine; Heart Rate; Hypertension; Male; Metopr | 1987 |
Influence of long-term antihypertensive therapy on cardiac function, coronary flow and myocardial oxygen consumption in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Coronary Circulation; Felodipine; Heart; Heart Rat | 1986 |
[Clinico-therapeutic evaluation of the hypertensive patient by the isometric exertion test].
Topics: Adult; Antihypertensive Agents; Atenolol; Blood Pressure; Chlorthalidone; Clonidine; Female; Humans; | 1986 |
Acute effects of dihydralazine mesylate, furosemide, and metoprolol on maternal hemodynamics in pregnancy-induced hypertension.
Topics: Adult; Blood Pressure; Blood Volume; Cardiac Output; Chorionic Villi; Dihydralazine; Female; Furosem | 1986 |
[Echocardiographic changes in hypertensive patients treated with a fixed combination of metoprolol and chlorthalidone].
Topics: Adult; Chlorthalidone; Delayed-Action Preparations; Drug Combinations; Echocardiography; Female; Hea | 1986 |
Rebound hypertension following abrupt cessation of clonidine and metoprolol. Treatment with labetalol.
Topics: Aged; Clonidine; Humans; Hypertension; Labetalol; Male; Metoprolol; Substance Withdrawal Syndrome | 1987 |
[Can beta-receptor blockers trigger coronary spasm?].
Topics: Cardiac Catheterization; Coronary Vasospasm; Exercise Test; Female; Humans; Hypertension; Male; Meto | 1987 |
Antihypertensive treatment and plasma lipoprotein levels. The associations in data from a population study.
Topics: Adult; Age Factors; Antihypertensive Agents; Australia; Blood Pressure; Cholesterol; Cholesterol, HD | 1986 |
Effect of felodipine and metoprolol on muscle and skin arteries in hypertensive patients.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Felodipine; Female; Heart Rate; Humans; Hypere | 1985 |
Clearance-based oral drug interaction between verapamil and metoprolol and comparison with atenolol.
Topics: Administration, Oral; Angina Pectoris; Atenolol; Drug Interactions; Drug Therapy, Combination; Femal | 1985 |
Ambulatory monitoring of blood pressure and arrhythmias by non-invasive methods in hypertensive patients treated with metoprolol.
Topics: Ambulatory Care; Arrhythmias, Cardiac; Blood Pressure; Blood Pressure Determination; Electrocardiogr | 1985 |
Pregnancy-induced increase in metoprolol metabolism.
Topics: Adult; Blood Proteins; Female; Humans; Hypertension; Kinetics; Metoprolol; Pregnancy; Pregnancy Comp | 1985 |