metoprolol has been researched along with Autoimmune Diabetes in 17 studies
Metoprolol: A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
metoprolol : A propanolamine that is 1-(propan-2-ylamino)propan-2-ol substituted by a 4-(2-methoxyethyl)phenoxy group at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of metoprolol on the counter-regulation of prolonged hypoglycemia was studied in eight insulin-dependent diabetics." | 9.06 | Effects of metoprolol on the counter-regulation and recognition of prolonged hypoglycemia in insulin-dependent diabetics. ( Adamson, U; Clausen-Sjöbom, N; Curstedt, T; Hamberger, B; Lins, PE, 1987) |
| "Metoprolol treatment improved in vagal tone assessed by short-term spectral analysis." | 6.70 | Effects on heart rate variability of metoprolol supplementary to ongoing ACE-inhibitor treatment in Type I diabetic patients with abnormal albuminuria. ( Ebbehøj, E; Hansen, KW; Knudsen, ST; Mogensen, CE; Mølgaard, H; Poulsen, PL, 2002) |
| "8 years) with microalbuminuria 31 (19-160) microg/min were randomised to treatment with enalapril (group 1, n = 7) or metoprolol (group 2, n = 6)." | 5.09 | Effect of angiotensin converting enzyme inhibitor or beta blocker on glomerular structural changes in young microalbuminuric patients with Type I (insulin-dependent) diabetes mellitus. ( Bangstad, HJ; Dahlquist, G; Osterby, R; Persson, B; Rudberg, S, 1999) |
| "The effect of metoprolol on the counter-regulation of prolonged hypoglycemia was studied in eight insulin-dependent diabetics." | 5.06 | Effects of metoprolol on the counter-regulation and recognition of prolonged hypoglycemia in insulin-dependent diabetics. ( Adamson, U; Clausen-Sjöbom, N; Curstedt, T; Hamberger, B; Lins, PE, 1987) |
| "Metoprolol treatment improved in vagal tone assessed by short-term spectral analysis." | 2.70 | Effects on heart rate variability of metoprolol supplementary to ongoing ACE-inhibitor treatment in Type I diabetic patients with abnormal albuminuria. ( Ebbehøj, E; Hansen, KW; Knudsen, ST; Mogensen, CE; Mølgaard, H; Poulsen, PL, 2002) |
| " The dose-response curve of isoprenaline/HR was significantly shifted to the right after hypoglycemia." | 2.68 | Reduced beta-adrenergic sensitivity in healthy volunteers induced by hypoglycemia. ( Jaeger, R; Jorde, R; Sager, G; Trovik, TS, 1995) |
| "Metoprolol was given together with the dose of isoprenaline which increased heart rate by 25 beats min-1." | 2.67 | Reduced sensitivity to beta-adrenoceptor stimulation and blockade in insulin dependent diabetic patients with hypoglycaemia unawareness. ( Jaeger, R; Jorde, R; Sager, G; Trovik, TS, 1994) |
| "However, in IDDM with blunted plasma glucagon responses, postnadir plasma glucose recovery was further decreased by propranolol (14 +/- 0." | 1.27 | The adrenergic contribution to glucose counterregulation in type I diabetes mellitus. Dependency on A-cell function and mediation through beta 2-adrenergic receptors. ( Angeletti, G; Bolli, G; Brunetti, P; Compagnucci, P; De Cosmo, S; De Feo, P; Gerich, JE; Motolese, M; Perriello, G; Santeusanio, F, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (29.41) | 18.7374 |
| 1990's | 8 (47.06) | 18.2507 |
| 2000's | 4 (23.53) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ebbehøj, E | 2 |
| Poulsen, PL | 2 |
| Hansen, KW | 3 |
| Knudsen, ST | 1 |
| Mølgaard, H | 2 |
| Mogensen, CE | 3 |
| Arildsen, H | 1 |
| Lager, I | 1 |
| Ostman, J | 1 |
| De Feo, P | 1 |
| Bolli, G | 1 |
| Perriello, G | 1 |
| De Cosmo, S | 1 |
| Compagnucci, P | 1 |
| Angeletti, G | 1 |
| Santeusanio, F | 1 |
| Gerich, JE | 1 |
| Motolese, M | 1 |
| Brunetti, P | 1 |
| Trovik, TS | 2 |
| Jaeger, R | 2 |
| Jorde, R | 3 |
| Sager, G | 3 |
| Rudberg, S | 4 |
| Sätterström, G | 1 |
| Dahlqvist, R | 1 |
| Dahlquist, G | 2 |
| Olbrich, A | 1 |
| Salameh, A | 1 |
| Roesen, P | 1 |
| Dhein, S | 1 |
| Osterby, R | 3 |
| Bangstad, HJ | 3 |
| Persson, B | 1 |
| Nyberg, G | 1 |
| Gulmann, C | 1 |
| Vea, H | 1 |
| Vaaler, S | 1 |
| Sundsfjord, J | 1 |
| Teschner, M | 1 |
| Schaefer, RM | 1 |
| Bahner, U | 1 |
| Heidland, A | 1 |
| Pedersen, MM | 1 |
| Christensen, CK | 1 |
| Christiansen, JS | 1 |
| Friedman, PJ | 1 |
| Dunn, PJ | 1 |
| Jury, DR | 1 |
| Clausen-Sjöbom, N | 1 |
| Lins, PE | 1 |
| Adamson, U | 1 |
| Curstedt, T | 1 |
| Hamberger, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Propranolol as a Treatment for Impaired Awareness of Hypoglycemia in Type 1 Diabetes[NCT03161964] | Phase 2 | 2 participants (Actual) | Interventional | 2017-10-19 | Terminated (stopped due to Statistical power could not be achieved due to low enrollment.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for metoprolol and Autoimmune Diabetes
| Article | Year |
|---|---|
beta-adrenergic blockade and diabetes mellitus. A review.
Topics: Adrenergic beta-Antagonists; Alprenolol; Blood Glucose; Catecholamines; Diabetes Mellitus, Type 1; D | 1983 |
[Nephropathy in type 1 diabetes mellitus. Current experimental and clinical aspects].
Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Diabetes Mellitus, Experimental; Dia | 1992 |
8 trials available for metoprolol and Autoimmune Diabetes
| Article | Year |
|---|---|
Effects on heart rate variability of metoprolol supplementary to ongoing ACE-inhibitor treatment in Type I diabetic patients with abnormal albuminuria.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Albuminuria; Angiotensin-Converting Enzyme Inhibitor | 2002 |
Effects of metoprolol on QT interval and QT dispersion in Type 1 diabetic patients with abnormal albuminuria.
Topics: Administration, Oral; Adult; Albuminuria; Chronic Disease; Cross-Over Studies; Denmark; Diabetes Mel | 2004 |
Reduced beta-adrenergic sensitivity in healthy volunteers induced by hypoglycemia.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 1; Dose-Response Relationship, Drug; Humans; Hypoglyce | 1995 |
Reduced sensitivity to beta-adrenoceptor stimulation and blockade in insulin dependent diabetic patients with hypoglycaemia unawareness.
Topics: Adult; Analysis of Variance; Awareness; Blood Glucose; Blood Pressure; Chromatography, High Pressure | 1994 |
Indomethacin but not metoprolol reduces exercise-induced albumin excretion rate in type 1 diabetic patients with microalbuminuria.
Topics: Adult; Albuminuria; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 1; Diabetic Nephropathies | 1993 |
Effect of angiotensin converting enzyme inhibitor or beta blocker on glomerular structural changes in young microalbuminuric patients with Type I (insulin-dependent) diabetes mellitus.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Albuminuria; Angiotensin-Converting Enzyme Inhibitor | 1999 |
The effect of selective beta 1-blockade on glucose thresholds for release of counterregulatory hormones and symptoms in insulin-dependent diabetes mellitus.
Topics: Adrenergic beta-Antagonists; Adult; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 1; Differ | 1992 |
Effects of metoprolol on the counter-regulation and recognition of prolonged hypoglycemia in insulin-dependent diabetics.
Topics: Adult; Blood Pressure; Diabetes Mellitus, Type 1; Female; Heart Rate; Hormones; Humans; Hypoglycemia | 1987 |
7 other studies available for metoprolol and Autoimmune Diabetes
| Article | Year |
|---|---|
Adrenergic blockade and hypoglycaemia.
Topics: Adrenergic beta-Antagonists; Blood Glucose; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Glucag | 1983 |
The adrenergic contribution to glucose counterregulation in type I diabetes mellitus. Dependency on A-cell function and mediation through beta 2-adrenergic receptors.
Topics: Adolescent; Adult; Blood Glucose; Diabetes Mellitus, Type 1; Hemodynamics; Humans; Insulin; Metoprol | 1983 |
Different effects of the beta-adrenoceptor antagonists celiprolol and metoprolol on vascular structure and function in long-term type I diabetic rats.
Topics: Adrenergic beta-Antagonists; Animals; Blood Chemical Analysis; Blood Vessels; Celiprolol; Cells, Cul | 1999 |
On glomerular structural alterations in type-1 diabetes. Companions of early diabetic glomerulopathy.
Topics: Adult; Albuminuria; Capillaries; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Enalapril; Extra | 2001 |
The juxtaglomerular apparatus in young type-1 diabetic patients with microalbuminuria. Effect of antihypertensive treatment.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Albuminuria; Angiotensin-Converting Enzyme Inhibitor | 2001 |
ACE-inhibition and renoprotection in early diabetic nephropathy. Response to enalapril acutely and in long-term combination with conventional antihypertensive treatment.
Topics: Adult; Albuminuria; Blood Pressure; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Drug Therapy, | 1991 |
Metoprolol and albumin excretion in diabetes.
Topics: Adult; Albuminuria; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Humans; Male; Metoprolol; Mid | 1986 |