metoprolol has been researched along with Arteriosclerosis in 19 studies
Metoprolol: A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
metoprolol : A propanolamine that is 1-(propan-2-ylamino)propan-2-ol substituted by a 4-(2-methoxyethyl)phenoxy group at position 1.
Arteriosclerosis: Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the review the basic studies devoted to researching of effectiveness of metoprolol in treatment of essential hypertension and also influence of this drug in the prognosis in this group of patients, are summarized." | 8.82 | [Metoprolol in the treatment of essential hypertension]. ( Minushkina, LO; Sidorenko, BA, 2003) |
| "In the Angina Prognosis Study in Stockholm (APSIS), 809 patients with stable angina pectoris were studied prospectively during double-blind treatment with verapamil or metoprolol." | 5.09 | Prognostic implications of intima-media thickness and plaques in the carotid and femoral arteries in patients with stable angina pectoris. ( Björkander, I; Eriksson, SV; Forslund, L; Held, C; Hjemdahl, P; Rehnqvist, N, 2001) |
| "In a randomized primary prevention trial including 3,234 men with mild to moderate uncomplicated hypertension, the effect of the beta-blocker metoprolol or a thiazide diuretic as an initial antihypertensive therapy was compared regarding the risk of sudden cardiovascular death during a follow-up ranging from 2." | 5.07 | Primary prevention of sudden cardiovascular death in hypertensive patients. Mortality results from the MAPHY Study. ( Barber, H; Berglund, G; Eliasson, K; Elmfeldt, D; Jastrup, B; Karatzas, N; Leer, J; Olsson, G; Tuomilehto, J; Warnold, I, 1991) |
| "The question whether initial antihypertensive treatment with a beta-blocker prevents hypertensive complications better than initial treatment with a non-betablocker, mainly diuretic based treatment, has been studied in recent large-scale studies like the Medical Research Council (MRC) trial, the International Prospective Primary Prevention Study in Hypertension (IPPPSH), the Heart Attack Primary Prevention in Hypertension (HAPPHY) study and the Metoprolol Atherosclerosis Prevention in Hypertensives (MAPHY) study." | 5.06 | Beta-blockers and diuretics. The HAPPHY and MAPHY studies. ( Berglund, G, 1989) |
| "The outcome of postinfarction patients with a history of hypertension who participated in a randomized, double-blind, secondary prevention study with metoprolol or placebo treatment for 3 years has been evaluated." | 5.06 | Thromboatherosclerotic complications in hypertensives: results of the Stockholm Metoprolol (secondary prevention) Trial. ( Olsson, G, 1988) |
| "In the review the basic studies devoted to researching of effectiveness of metoprolol in treatment of essential hypertension and also influence of this drug in the prognosis in this group of patients, are summarized." | 4.82 | [Metoprolol in the treatment of essential hypertension]. ( Minushkina, LO; Sidorenko, BA, 2003) |
| " Chloralose anesthesia was used to induce sympathetic activation and the presence of intracellular IgG as a criterion of endothelial cell injury." | 3.68 | Experimental sympathetic activation causes endothelial injury in the rabbit thoracic aorta via beta 1-adrenoceptor activation. ( Bejne, B; Björk, H; Bondjers, G; Pettersson, K; Strawn, WB, 1990) |
| "Pretreatment with metoprolol in a dose resulting in "therapeutic" plasma levels significantly reduced platelet accumulation by 48% in unbranched aorta, 65% at intercostal, and 53% at coronary artery bifurcations." | 1.28 | Inhibition of platelet accumulation by beta 1-adrenoceptor blockade in the thoracic aorta of rabbits subjected to experimental sympathetic activation. ( Björk, H; Pettersson, K, 1992) |
| "Metoprolol treatment caused an 8% decrease in heart rate and a 13% decrease in blood pressure and led to a rise in plasma triglycerides, 24%, 17% and 34% after 1, 3 and 6 months of metoprolol treatment, respectively." | 1.28 | Effect of metoprolol on plasma lipids and arterial intimal lipid deposition in spontaneously hypertensive rats. ( Eklund, A; Jönsson, L; Ostlund-Lindqvist, AM; Sjöblom, L, 1989) |
| "The metoprolol-treated animals in groups 1 and 2 had a reduction of atherosclerosis compared with their respective controls." | 1.27 | Atherosclerosis in rabbits identified as high and low responders to an atherogenic diet and the effect of treatment with a beta 1-blocker. ( Bondjers, G; Bräutigam, J; Lindqvist, P; Nordborg, C; Olsson, G; Ostlund-Lindqvist, AM, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (52.63) | 18.7374 |
| 1990's | 5 (26.32) | 18.2507 |
| 2000's | 4 (21.05) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Korkmaz, ME | 1 |
| Atar, I | 1 |
| Tayfun, E | 1 |
| Yildirir, A | 1 |
| Ulucam, M | 1 |
| Ozin, B | 1 |
| Muderrisoglu, H | 1 |
| Turan, M | 1 |
| Minushkina, LO | 1 |
| Sidorenko, BA | 1 |
| Vidt, DG | 1 |
| Blumlein, SL | 1 |
| Sievers, R | 1 |
| Kidd, P | 1 |
| Parmley, WW | 2 |
| Sun, YP | 1 |
| Zhu, BQ | 1 |
| Sievers, RE | 1 |
| Glantz, SA | 1 |
| Held, C | 1 |
| Hjemdahl, P | 1 |
| Eriksson, SV | 1 |
| Björkander, I | 1 |
| Forslund, L | 1 |
| Rehnqvist, N | 1 |
| Hedblad, B | 1 |
| Wikstrand, J | 1 |
| Janzon, L | 1 |
| Wedel, H | 1 |
| Berglund, G | 3 |
| Pettersson, K | 2 |
| Björk, H | 2 |
| Strawn, WB | 2 |
| Bondjers, G | 3 |
| Kaplan, JR | 1 |
| Manuck, SB | 1 |
| Schwenke, DC | 1 |
| Hansson, GK | 1 |
| Shively, CA | 1 |
| Clarkson, TB | 1 |
| Olsson, G | 3 |
| Tuomilehto, J | 1 |
| Elmfeldt, D | 1 |
| Warnold, I | 1 |
| Barber, H | 1 |
| Eliasson, K | 1 |
| Jastrup, B | 1 |
| Karatzas, N | 1 |
| Leer, J | 1 |
| Bejne, B | 1 |
| Moser, M | 1 |
| Sheps, S | 1 |
| Holme, I | 1 |
| Ostlund-Lindqvist, AM | 2 |
| Eklund, A | 1 |
| Sjöblom, L | 1 |
| Jönsson, L | 1 |
| Spence, JD | 1 |
| Lindqvist, P | 1 |
| Nordborg, C | 1 |
| Bräutigam, J | 1 |
| Chobanian, AV | 1 |
| Brecher, P | 1 |
| Chan, C | 1 |
2 reviews available for metoprolol and Arteriosclerosis
| Article | Year |
|---|---|
[Metoprolol in the treatment of essential hypertension].
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Arteriosclerosis; Humans; Hypertension; Metopr | 2003 |
Advances in the medical management of renovascular hypertension.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Arteriosclerosis; Atenolol | 1984 |
7 trials available for metoprolol and Arteriosclerosis
| Article | Year |
|---|---|
Prognostic implications of intima-media thickness and plaques in the carotid and femoral arteries in patients with stable angina pectoris.
Topics: Aged; Angina Pectoris; Arteriosclerosis; Carotid Arteries; Carotid Artery Diseases; Coronary Artery | 2001 |
Low-dose metoprolol CR/XL and fluvastatin slow progression of carotid intima-media thickness: Main results from the Beta-Blocker Cholesterol-Lowering Asymptomatic Plaque Study (BCAPS).
Topics: Aged; Anticholesteremic Agents; Antihypertensive Agents; Arteriosclerosis; Blood Pressure; Cardiovas | 2001 |
Primary prevention of sudden cardiovascular death in hypertensive patients. Mortality results from the MAPHY Study.
Topics: Adult; Arteriosclerosis; Bendroflumethiazide; Death, Sudden; Diuretics; Follow-Up Studies; Humans; H | 1991 |
Beta-blockers and diuretics. The HAPPHY and MAPHY studies.
Topics: Adrenergic beta-Antagonists; Arteriosclerosis; Benzothiadiazines; Cerebrovascular Disorders; Coronar | 1989 |
Confusing messages from the newest of the beta-blocker/diuretic hypertension trials. The Metoprolol Atherosclerosis Prevention in Hypertensives trial.
Topics: Adrenergic beta-Antagonists; Arteriosclerosis; Cardiovascular Diseases; Clinical Trials as Topic; Di | 1989 |
Quantitative spectral analysis of carotid Doppler signal: evaluation as a method for measurement of drug effects.
Topics: Adult; Arteriosclerosis; Carotid Arteries; Carotid Artery Diseases; Double-Blind Method; Heart Rate; | 1989 |
Thromboatherosclerotic complications in hypertensives: results of the Stockholm Metoprolol (secondary prevention) Trial.
Topics: Arteriosclerosis; Cause of Death; Clinical Trials as Topic; Double-Blind Method; Humans; Hypertensio | 1988 |
10 other studies available for metoprolol and Arteriosclerosis
| Article | Year |
|---|---|
Effects of a beta-blocker and spironolactone on plasma homocysteine levels.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Arteriosclerosis; Homocysteine; Humans; Metoprolol; Middle | 2003 |
Mechanism of protection from atherosclerosis by verapamil in the cholesterol-fed rabbit.
Topics: Animals; Aorta; Arteriosclerosis; Blood Pressure; Cholesterol; Cholesterol, Dietary; Heart Rate; Hyd | 1984 |
Metoprolol does not attenuate atherosclerosis in lipid-fed rabbits exposed to environmental tobacco smoke.
Topics: Animals; Aorta; Arteriosclerosis; Cholesterol, Dietary; Male; Metoprolol; Pulmonary Artery; Rabbits; | 1994 |
Inhibition of platelet accumulation by beta 1-adrenoceptor blockade in the thoracic aorta of rabbits subjected to experimental sympathetic activation.
Topics: Analysis of Variance; Animals; Aorta, Thoracic; Arteriosclerosis; Blood Platelets; Chloralose; Hemod | 1992 |
Endothelial dysfunction in response to psychosocial stress in monkeys.
Topics: Animals; Aorta, Abdominal; Arteriosclerosis; Carotid Arteries; Cell Survival; Coronary Vessels; Endo | 1991 |
Experimental sympathetic activation causes endothelial injury in the rabbit thoracic aorta via beta 1-adrenoceptor activation.
Topics: Anesthesia; Animals; Aorta, Thoracic; Arteriosclerosis; Blood Pressure; Cell Survival; Chloralose; E | 1990 |
MAPHY and the two arms of HAPPHY.
Topics: Adrenergic beta-Antagonists; Arteriosclerosis; Benzothiadiazines; Coronary Disease; Diuretics; Human | 1989 |
Effect of metoprolol on plasma lipids and arterial intimal lipid deposition in spontaneously hypertensive rats.
Topics: Animals; Aorta; Arteriosclerosis; Coronary Vessels; Diet, Atherogenic; Hypertension; Lipids; Male; M | 1989 |
Atherosclerosis in rabbits identified as high and low responders to an atherogenic diet and the effect of treatment with a beta 1-blocker.
Topics: Animals; Aorta; Apolipoproteins; Arteriosclerosis; Cholesterol; Coronary Vessels; Diet, Atherogenic; | 1988 |
Effects of propranolol on atherogenesis in the cholesterol-fed rabbit.
Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Cholesterol; Cholesterol Esters; Cholesterol, Dietary; M | 1985 |