metoprolol and Arrhythmia studies

Metoprolol: A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
metoprolol : A propanolamine that is 1-(propan-2-ylamino)propan-2-ol substituted by a 4-(2-methoxyethyl)phenoxy group at position 1.

Research Excerpts

Excerpt	Relevance	Reference
"To investigate the effects of carvedilol and metoprolol on the expression of autoantibodies against cardiac β(1), β(2) and α(1) adrenergic receptors in aged patients with chronic heart failure (CHF) and ventricular arrhythmia (VA)."	9.14	[Effects of carvedilol and metoprolol on expression of autoantibodies against cardiac adrenergic receptors in aged patients with chronic heart failure and ventricular arrhythmia]. ( Li, XD; Wang, JC; Ye, L; Zhao, Y; Zhou, NN; Zhu, X, 2010)
"We assessed the influence of metoprolol on heart rate variability in survivors of remote myocardial infarction."	9.08	Influence of metoprolol on heart rate variability in survivors of remote myocardial infarction. ( Hillis, LD; Keeley, EC; Landau, C; Lange, RA; Page, RL; Willard, JE, 1996)
"Fifty three of the 5778 patients included in the MIAMI (Metoprolol in Acute Myocardial Infarction) trial were investigated with long-term ECG recordings in order to evaluate the effect of acute beta-blockade on premature ventricular complexes in and after acute myocardial infarction."	9.06	Metoprolol in acute myocardial infarction reduces ventricular arrhythmias both in the early stage and after the acute event. ( Ekman, AM; Erhardt, L; Olsson, G; Rehnqvist, N, 1987)
"One-hundred and ninety-seven consecutive patients admitted for suspected acute myocardial infarction were randomized to double-blind treatment with intravenous followed by oral metoprolol or matching placebo within 24 hours (mean 6."	9.06	Effect of metoprolol on early exercise-induced ST-segment changes and ventricular arrhythmias in patients with suspected acute myocardial infarction. ( Abrahamsen, AM; Gundersen, T; Knutsen, H; Rønnevik, PK; Woie, L, 1989)
"The effects of metoprolol, administered in the early stages of acute myocardial infarction was studied in 126 patients."	9.06	The effects of metoprolol given early in acute myocardial infarction on ventricular arrhythmias. ( Littler, WA; Murray, DP; Murray, RG, 1986)
"The effects of metoprolol treatment in patients surviving acute myocardial infarction have been investigated in a double-blind randomized study."	9.05	Long-term treatment with metoprolol after myocardial infarction: effect on 3 year mortality and morbidity. ( Erhardt, L; Lundman, T; Olsson, G; Rehnqvist, N; Sjögren, A, 1985)
"This study documents the extent of suppression of premature ventricular beats which can be achieved with metoprolol, a semiselective beta-adrenergic blocking agent, at doses of 100 to 200 mg daily, utilizing a single-blind placebo-controlled 10-day protocol with continuous ambulatory electrocardiographic recording of 20 patients with cardiac disease and complex ventricular arrhythmias."	9.05	Evaluation of metoprolol in suppressing complex ventricular arrhythmias. ( Bloom, MG; Pratt, CM; Quinones, MA; Taylor, AA; Yepsen, SC; Young, JB, 1983)
"During the intervening years since metoprolol was first reviewed in the Journal (1977), it has become widely used in the treatment of mild to moderate hypertension and angina pectoris."	8.77	Metoprolol. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in hypertension, ischaemic heart disease and related cardiovascular disorders. ( Benfield, P; Brogden, RN; Clissold, SP, 1986)
"We identified that carvedilol, a β-blocker not commonly used in HCM, suppresses contractile function and arrhythmia by inhibiting RyR2 (ryanodine receptor type 2)."	8.31	Improved Cardiac Performance and Decreased Arrhythmia in Hypertrophic Cardiomyopathy With Non-β-Blocking R-Enantiomer Carvedilol. ( Ashley, EA; Bernstein, D; Huang, Y; Kawana, M; Kirillova, A; Lane, KV; Parikh, VN; Perez, MV; Pruitt, BL; Seo, K; Wang, Q; Wheeler, MT; Wu, JC; Yadav, S; Yamamoto, Y, 2023)
"To explore the effect of metoprolol tartrate tablets and recombinant human natriuretic peptide B (NPPB) on sudden cardiac death and malignant arrhythmias in patients with acute myocardial infarction and patients with heart failure (AMI-HF)."	8.02	Effect of metoprolol tartrate tablets and recombinant human B-type natriuretic peptide on the sudden cardiac death and malignant arrhythmias in patients with acute myocardial infarction and heart failure. ( Lin, Y; Liu, C; Yao, L; Zhang, L, 2021)
" This study aimed to investigate the effect of 24-h sleep deprivation on heart rate variability (HRV) in young healthy people and the protective effect of metoprolol on arrhythmia."	7.79	Protective effect of metoprolol on arrhythmia and heart rate variability in healthy people with 24 hours of sleep deprivation. ( Chen, WR; Gao, LG; Shi, XM; Yang, TS; Zhao, LC, 2013)
"Metoprolol reduces post-MI ventricular arrhythmias, partly by altering the neural remodeling process."	7.74	Effects of prolonged metoprolol treatment on neural remodeling and inducible ventricular arrhythmias after myocardial infarction in rabbits. ( Cheng, WJ; Hu, HS; Shi, CW; Wang, Q; Wang, XL; Xing, QC; Xue, M; Yan, SH, 2007)
" The aim of this study was to investigate the effects of metoprolol on sympathetic remodeling and electrical remodeling at the infarcted border zone (IBZ) after myocardial infarction (MI)."	7.74	Effects of metoprolol on sympathetic remodeling and electrical remodeling at infarcted border zone after myocardial infarction in rabbits. ( Huang, C; Jian, X; Jiang, H; Lu, Z; Yang, B; Yu, Y; Zhao, D, 2007)
"Metoprolol succinate was given to 60 patients with class I-III heart failure and ejection fraction <45% after myocardial infarction."	7.72	[Effect of metoprolol CR/XL on remodeling of the heart and cardiac rhythm disturbances after myocardial infarction in patients with chronic heart failure]. ( Churganova, LIu; Gavril'eva, SA; Ivanov, GG; Poltavskaia, MG; Sheianov, MV; Shumilova, KM; Syrkin, AL, 2003)
"In the isolated rat heart, reperfusion-induced arrhythmias were exacerbated by isoproterenol (0."	7.68	Isoproterenol and the genesis of reperfusion-induced arrhythmias in isolated rat heart: adrenoceptor or free radical-mediated mechanisms? ( Hearse, DJ; Tosaki, A; Woodward, B; Yamamoto, F, 1990)
" We compared the effect of selective beta 1 and beta 2 adrenoceptor antagonists on the genesis of halothane-epinephrine arrhythmias in dogs."	7.68	Selective beta 1 and beta 2 adrenoceptor blockade on epinephrine-induced arrhythmias in halothane anaesthetized dogs. ( Hayashi, Y; Kamibayashi, T; Kuro, M; Mammoto, T; Sumikawa, K; Yamatodani, A; Yoshiya, I, 1992)
"During the initial hospitalization, ventricular fibrillation (VF) developed in 6 metoprolol-treated patients (0."	7.67	Göteborg Metoprolol Trial: effects on arrhythmias. ( Edvardsson, N; Herlitz, J; Hjalmarson, A; Holmberg, S; Rydén, L; Swedberg, K; Waagstein, F; Waldenström, A, 1984)
"2 X 10(-4) mol/l, in comparison to that of metoprolol (10(-5) mol/l) and diltiazem (10(-7) mol/l), two widely used antiarrhythmic agents, on ischemia- and reperfusion-induced arrhythmias and heart functions, such as heart rate (HR), coronary flow (CF), aortic flow (AF), left ventricular developed pressure (LVDP), its first derivative (LVdp/dtmax), and left ventricular end-diastolic pressure (LVEDP) in isolated working rat hearts was examined."	7.67	Ginkgolide B protects isolated hearts against arrhythmias induced by ischemia but not reperfusion. ( Braquet, P; Hosford, D; Koltai, M; Tosaki, A, 1989)
"The antiarrhythmic effects of dl'propranolol, d-propranolol, metoprolol and lidocaine against ouabain-induced cardiac arrhythmias were studied."	7.66	Effects of adrenergic beta-blockers and a membrane stabilizing agent on ouabain-induced cardiac arrhythmias in anaesthetized guinea pigs. ( Aberg, G; Adler, G; Duker, G; Ek, B; Telemo, E, 1979)
"Amiodarone has pharmacokinetic interactions with a number of therapeutic drugs, including warfarin, phenytoin, flecainide, and cyclosporine."	6.72	Effect of amiodarone on the serum concentration/dose ratio of metoprolol in patients with cardiac arrhythmia. ( Fukumoto, K; Kamakura, S; Kato, R; Kitakaze, M; Kobayashi, T; Komamura, K; Tachibana, K; Tanaka, K; Ueno, K, 2006)
"In metoprolol treated patients in whom the arrhythmia frequency was reduced by greater than 75% after three days of treatment, mortality was lower as compared to those metoprolol treated patients who did not show this treatment response (3% vs 28%, P = 0."	6.66	Evaluation of antiarrhythmic effect of metoprolol treatment after acute myocardial infarction: relationship between treatment responses and survival during a 3-year follow-up. ( Olsson, G; Rehnqvist, N, 1986)
"In the last year, two large randomized controlled trials of metoprolol (MIAMI, almost 6,000 patients) and atenolol (ISIS 1, over 16,000 patients) given intravenously within 12 hours of the onset of acute myocardial infarction reduced mortality by about 15% in low-risk subjects."	6.15	Use of beta adrenoceptor blockade during and after acute myocardial infarction. ( Sleight, P, 1986)
"Metoprolol was given 20 mg/kg/day for 5 weeks after MI surgery."	5.48	Comparison between renal denervation and metoprolol on the susceptibility of ventricular arrhythmias in rats with myocardial infarction. ( Chen, C; Geng, J; Huo, J; Jiang, W; Jiang, Z; Lu, D; Shan, Q; Xu, H, 2018)
"A distinct phase of ventricular arrhythmias was evident about 10 to 30 min after ligation."	5.27	Prevention of ventricular fibrillation by metoprolol in a pig model of acute myocardial ischaemia: absence of a major arrhythmogenic role for cyclic AMP. ( Gihwala, D; Hamm, CW; Muller, CA; Opie, LH; Peisach, M, 1986)
"The arrhythmias were prevented by higher doses of the calcium antagonist verapamil which, however, decreased the survival times."	5.26	Comparative investigation of the effects of metoprolol, propranolol, practolol, and verapamil in the acute phase of experimental myocardial infarction. ( Bernauer, W, 1982)
" There were no significant differences in the secondary endpoints of recurrent angina, readmission, and tachyarrhythmias except for more first- and second-degree AV blocks with metoprolol (12."	5.24	Ivabradine vs metoprolol in patients with acute inferior wall myocardial infarction-"Expanding arena for ivabradine". ( Bisht, DS; Gokhroo, RK; Gupta, S; Kishore, K; Priti, K; Ranwa, BL, 2017)
"To investigate the effects of carvedilol and metoprolol on the expression of autoantibodies against cardiac β(1), β(2) and α(1) adrenergic receptors in aged patients with chronic heart failure (CHF) and ventricular arrhythmia (VA)."	5.14	[Effects of carvedilol and metoprolol on expression of autoantibodies against cardiac adrenergic receptors in aged patients with chronic heart failure and ventricular arrhythmia]. ( Li, XD; Wang, JC; Ye, L; Zhao, Y; Zhou, NN; Zhu, X, 2010)
"Addition of low-dose metoprolol to sibutramine therapy increased patient compliance to the treatment, and decreased the frequency and severity of side effects including hypertension and palpitations, without decreasing the drug efficacy or causing significant deleterious changes in metabolic parameters."	5.11	Effect of low-dose metoprolol in combination with sibutramine therapy in normotensive obese patients: a randomized controlled study. ( Baykan, M; Durmus, I; Erem, C; Ersoz, HO; Hacihasanoglu, A; Telatar, M; Ukinc, K, 2004)
"We assessed the influence of metoprolol on heart rate variability in survivors of remote myocardial infarction."	5.08	Influence of metoprolol on heart rate variability in survivors of remote myocardial infarction. ( Hillis, LD; Keeley, EC; Landau, C; Lange, RA; Page, RL; Willard, JE, 1996)
"A randomized study was performed on 70 patients undergoing elective coronary bypass grafting to examine whether the combined infusion of the calcium channel blocker nifedipine (10 micrograms/kg per hour) and the beta 1-blocker metopropol (12 micrograms/kg per hour, n = 34) reduces the prevalence of perioperative myocardial ischemia and arrhythmias."	5.08	Comparison of perioperative myocardial protection with nifedipine versus nifedipine and metoprolol in patients undergoing elective coronary artery bypass grafting. ( Binder, TM; Podesser, BK; Schwarzacher, S; Seitelberger, R; Wolner, E; Zwoelfer, W, 1995)
"The efficacy of sotalol in the treatment of sustained ventricular arrhythmias has been proved; however, whether its antiarrhythmic effect is due to a beta-blocking activity, a class III antiarrhythmic activity, or a combination of both is not known."	5.08	Metoprolol versus sotalol in the treatment of sustained ventricular tachycardia. ( Antz, M; Cappato, R; Kuck, KH, 1995)
"A randomized study was performed on 70 patients undergoing elective coronary bypass surgery to examine whether the combined, perioperative, 24-hour infusion of the calcium-channel blocker nifedipine (10 micrograms/kg/h) and the beta 1-blocker metoprolol (12 micrograms/kg/h) reduces the incidence of perioperative myocardial ischemia and arrhythmias (group NM, n = 34)."	5.07	Combined perioperative infusion of nifedipine and metoprolol provides antiischemic and antiarrhythmic protection in patients undergoing elective aortocoronary bypass surgery. ( Binder, TM; Huber, S; Peschl, F; Podesser, B; Schwarzacher, S; Seitelberger, R; Spatt, J; Zwölfer, W, 1993)
"A randomised study was performed on 70 patients undergoing elective coronary by-pass procedure to examine whether the combined, perioperative, 24-hour infusion of nifedipine and metoprolol reduces the incidence of perioperative myocardial ischemia and arrhythmias."	5.07	Perioperative infusion of nifedipine and metoprolol provides antiischemic and antiarrhythmic protection in patients undergoing elective aortocoronary by-pass surgery. ( Binder, T; Huber, S; Peschl, F; Podesser, B; Schwarzacher, S; Seitelberger, R; Spatt, J; Wolner, E; Zwölfer, W, 1994)
" Patients whose arrhythmia was inducible by programmed electrical stimulation were assigned to treatment with electrophysiologically guided drug therapy based on serial testing (61 patients) or with metoprolol (54 patients)."	5.07	A comparison of electrophysiologically guided antiarrhythmic drug therapy with beta-blocker therapy in patients with symptomatic, sustained ventricular tachyarrhythmias. ( Andresen, D; Bach, P; Haberl, R; Hoffmann, E; Oeff, M; Steinbeck, G; von Leitner, ER, 1992)
"The effects of metoprolol, administered in the early stages of acute myocardial infarction was studied in 126 patients."	5.06	The effects of metoprolol given early in acute myocardial infarction on ventricular arrhythmias. ( Littler, WA; Murray, DP; Murray, RG, 1986)
"One-hundred and ninety-seven consecutive patients admitted for suspected acute myocardial infarction were randomized to double-blind treatment with intravenous followed by oral metoprolol or matching placebo within 24 hours (mean 6."	5.06	Effect of metoprolol on early exercise-induced ST-segment changes and ventricular arrhythmias in patients with suspected acute myocardial infarction. ( Abrahamsen, AM; Gundersen, T; Knutsen, H; Rønnevik, PK; Woie, L, 1989)
"Fifty three of the 5778 patients included in the MIAMI (Metoprolol in Acute Myocardial Infarction) trial were investigated with long-term ECG recordings in order to evaluate the effect of acute beta-blockade on premature ventricular complexes in and after acute myocardial infarction."	5.06	Metoprolol in acute myocardial infarction reduces ventricular arrhythmias both in the early stage and after the acute event. ( Ekman, AM; Erhardt, L; Olsson, G; Rehnqvist, N, 1987)
"The Göteborg Metoprolol Trial was a double-blind, placebo-controlled, stratified trial aimed at evaluating the effect of the beta 1-selective blocker, metoprolol, in suspected acute myocardial infarction and during 2 years of follow-up."	5.05	Göteborg Metoprolol Trial: design, patient characteristics and conduct. ( Herlitz, J; Holmberg, S; Pennert, K; Swedberg, K; Vedin, A; Waagstein, F; Waldenström, A; Waldenström, J; Wedel, H; Wilhelmsen, L, 1984)
"This study documents the extent of suppression of premature ventricular beats which can be achieved with metoprolol, a semiselective beta-adrenergic blocking agent, at doses of 100 to 200 mg daily, utilizing a single-blind placebo-controlled 10-day protocol with continuous ambulatory electrocardiographic recording of 20 patients with cardiac disease and complex ventricular arrhythmias."	5.05	Evaluation of metoprolol in suppressing complex ventricular arrhythmias. ( Bloom, MG; Pratt, CM; Quinones, MA; Taylor, AA; Yepsen, SC; Young, JB, 1983)
"The effects of metoprolol treatment in patients surviving acute myocardial infarction have been investigated in a double-blind randomized study."	5.05	Long-term treatment with metoprolol after myocardial infarction: effect on 3 year mortality and morbidity. ( Erhardt, L; Lundman, T; Olsson, G; Rehnqvist, N; Sjögren, A, 1985)
" Our case report describes a patient with an arrhythmia who suffered reversible dysosmia and hypogeusia after taking metoprolol and amiodarone, respectively."	4.98	Antiarrhythmic drug-induced smell and taste disturbances: A case report and literature review. ( Che, X; Fang, Y; Li, Y; Reis, C; Wang, H, 2018)
"During the intervening years since metoprolol was first reviewed in the Journal (1977), it has become widely used in the treatment of mild to moderate hypertension and angina pectoris."	4.77	Metoprolol. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in hypertension, ischaemic heart disease and related cardiovascular disorders. ( Benfield, P; Brogden, RN; Clissold, SP, 1986)
"We identified that carvedilol, a β-blocker not commonly used in HCM, suppresses contractile function and arrhythmia by inhibiting RyR2 (ryanodine receptor type 2)."	4.31	Improved Cardiac Performance and Decreased Arrhythmia in Hypertrophic Cardiomyopathy With Non-β-Blocking R-Enantiomer Carvedilol. ( Ashley, EA; Bernstein, D; Huang, Y; Kawana, M; Kirillova, A; Lane, KV; Parikh, VN; Perez, MV; Pruitt, BL; Seo, K; Wang, Q; Wheeler, MT; Wu, JC; Yadav, S; Yamamoto, Y, 2023)
"To explore the effect of metoprolol tartrate tablets and recombinant human natriuretic peptide B (NPPB) on sudden cardiac death and malignant arrhythmias in patients with acute myocardial infarction and patients with heart failure (AMI-HF)."	4.02	Effect of metoprolol tartrate tablets and recombinant human B-type natriuretic peptide on the sudden cardiac death and malignant arrhythmias in patients with acute myocardial infarction and heart failure. ( Lin, Y; Liu, C; Yao, L; Zhang, L, 2021)
" This study aimed to investigate the effect of 24-h sleep deprivation on heart rate variability (HRV) in young healthy people and the protective effect of metoprolol on arrhythmia."	3.79	Protective effect of metoprolol on arrhythmia and heart rate variability in healthy people with 24 hours of sleep deprivation. ( Chen, WR; Gao, LG; Shi, XM; Yang, TS; Zhao, LC, 2013)
"Carvedilol is one of the most effective beta blockers for preventing ventricular tachyarrhythmias in heart failure, but the mechanisms underlying its favorable antiarrhythmic benefits remain unclear."	3.77	Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release. ( Back, TG; Chen, H; Chen, J; Chen, SR; Chen, W; Cheng, H; Duff, HJ; Feldman, AM; Fill, M; Gillis, AM; Guo, A; Jiang, D; Jones, PP; Li, X; Smith, CD; Song, LS; Tian, X; Vembaiyan, K; Wang, A; Wang, R; Xiao, J; Xie, C; Yang, D; Zhang, J; Zhang, L; Zhong, X; Zhou, Q; Zhu, W, 2011)
"Metoprolol reduces post-MI ventricular arrhythmias, partly by altering the neural remodeling process."	3.74	Effects of prolonged metoprolol treatment on neural remodeling and inducible ventricular arrhythmias after myocardial infarction in rabbits. ( Cheng, WJ; Hu, HS; Shi, CW; Wang, Q; Wang, XL; Xing, QC; Xue, M; Yan, SH, 2007)
" The aim of this study was to investigate the effects of metoprolol on sympathetic remodeling and electrical remodeling at the infarcted border zone (IBZ) after myocardial infarction (MI)."	3.74	Effects of metoprolol on sympathetic remodeling and electrical remodeling at infarcted border zone after myocardial infarction in rabbits. ( Huang, C; Jian, X; Jiang, H; Lu, Z; Yang, B; Yu, Y; Zhao, D, 2007)
"Baroreflex sensitivity was assessed in 287 patients with history of myocardial infarction and left ventricular ejection fraction < or =40% by phenylephrine test and was found to be depressed (4."	3.72	[Correction of baroreflex sensitivity impairment and efficacy of prevention of sudden arrhythmic death in patients with postinfarction left ventricular dysfunction]. ( Bozhko, AA; Kanopskiĭ, SG; Staritskiĭ, AG, 2004)
"Metoprolol succinate was given to 60 patients with class I-III heart failure and ejection fraction <45% after myocardial infarction."	3.72	[Effect of metoprolol CR/XL on remodeling of the heart and cardiac rhythm disturbances after myocardial infarction in patients with chronic heart failure]. ( Churganova, LIu; Gavril'eva, SA; Ivanov, GG; Poltavskaia, MG; Sheianov, MV; Shumilova, KM; Syrkin, AL, 2003)
"The effect of long-term treatment with propafenone, metoprolol and amiodarone was studied on the activity of Na,K-adenosine triphosphatase in lymphocytes and the plasma level of cAMP in patients with ventricular arrhythmias."	3.69	[The effect of treatment with propafenone, metoprolol and amiodarone on lymphocyte sodium efflux and level of cAMP in serum]. ( Kosmala, W, 1995)
"Disopyramide as an antiarrhythmic can be prescribed to patients with atrial fibrillation and, owing to its negative inotropic effect, to patients with hypertrophic obstructive cardiomyopathy."	3.69	Heart conduction disturbances and cardiovascular collapse after disopyramide and low-dose metoprolol in a patient with hypertrophic obstructive cardiomyopathy. ( Horvat, M; Pernat, A; Pohar, B, 1997)
" We compared the effect of selective beta 1 and beta 2 adrenoceptor antagonists on the genesis of halothane-epinephrine arrhythmias in dogs."	3.68	Selective beta 1 and beta 2 adrenoceptor blockade on epinephrine-induced arrhythmias in halothane anaesthetized dogs. ( Hayashi, Y; Kamibayashi, T; Kuro, M; Mammoto, T; Sumikawa, K; Yamatodani, A; Yoshiya, I, 1992)
"In the isolated rat heart, reperfusion-induced arrhythmias were exacerbated by isoproterenol (0."	3.68	Isoproterenol and the genesis of reperfusion-induced arrhythmias in isolated rat heart: adrenoceptor or free radical-mediated mechanisms? ( Hearse, DJ; Tosaki, A; Woodward, B; Yamamoto, F, 1990)
"During the initial hospitalization, ventricular fibrillation (VF) developed in 6 metoprolol-treated patients (0."	3.67	Göteborg Metoprolol Trial: effects on arrhythmias. ( Edvardsson, N; Herlitz, J; Hjalmarson, A; Holmberg, S; Rydén, L; Swedberg, K; Waagstein, F; Waldenström, A, 1984)
"35%) anesthesia, the arrhythmogenic dose of epinephrine (ADE) was repeatedly determined before and after prazosin (alpha 1 antagonist; 0."	3.67	Alterations in the arrhythmogenic dose of epinephrine after adrenergic receptor blockade with prazosin, metoprolol, or yohimbine in halothane-xylazine-anesthetized dogs. ( Benson, GJ; Thurmon, JC; Tranquilli, WJ, 1986)
"2 X 10(-4) mol/l, in comparison to that of metoprolol (10(-5) mol/l) and diltiazem (10(-7) mol/l), two widely used antiarrhythmic agents, on ischemia- and reperfusion-induced arrhythmias and heart functions, such as heart rate (HR), coronary flow (CF), aortic flow (AF), left ventricular developed pressure (LVDP), its first derivative (LVdp/dtmax), and left ventricular end-diastolic pressure (LVEDP) in isolated working rat hearts was examined."	3.67	Ginkgolide B protects isolated hearts against arrhythmias induced by ischemia but not reperfusion. ( Braquet, P; Hosford, D; Koltai, M; Tosaki, A, 1989)
"The antiarrhythmic effects of dl'propranolol, d-propranolol, metoprolol and lidocaine against ouabain-induced cardiac arrhythmias were studied."	3.66	Effects of adrenergic beta-blockers and a membrane stabilizing agent on ouabain-induced cardiac arrhythmias in anaesthetized guinea pigs. ( Aberg, G; Adler, G; Duker, G; Ek, B; Telemo, E, 1979)
"Sixty patients with arrhythmia after hepatectomy for primary liver cancer were selected as the research objects."	3.01	Dynamic Electrocardiogram under P Wave Detection Algorithm Combined with Low-Dose Betaloc in Diagnosis and Treatment of Patients with Arrhythmia after Hepatocarcinoma Resection. ( Chu, Z; Han, B; Jiang, F; Liu, X; Shi, X; Xu, B; Xu, H, 2021)
"In a nonrestricted STEMI population, early intravenous metoprolol before PPCI was not associated with a reduction in infarct size."	2.82	Early Intravenous Beta-Blockers in Patients With ST-Segment Elevation Myocardial Infarction Before Primary Percutaneous Coronary Intervention. ( Albarran, A; Alfonso, F; Alonso, J; Botas, J; Dambrink, JE; de Smet, B; Escalera, N; Fernández-Avilés, F; Fernández-Ortiz, A; Fuster, V; García-Lledó, A; Goicolea, J; Gosselink, M; Hernandez-Jaras, V; Ibáñez, B; Kedhi, E; Kolkman, E; Lipsic, E; Mateos, A; Navarro, F; Nijveldt, R; Ottervanger, JP; Piek, JJ; Pizarro, G; Postma, S; Rasoul, S; Remkes, W; Roolvink, V; van 't Hof, AWJ; van Leeuwen, M; van Royen, N; Zamorano, JL, 2016)
"Amiodarone has pharmacokinetic interactions with a number of therapeutic drugs, including warfarin, phenytoin, flecainide, and cyclosporine."	2.72	Effect of amiodarone on the serum concentration/dose ratio of metoprolol in patients with cardiac arrhythmia. ( Fukumoto, K; Kamakura, S; Kato, R; Kitakaze, M; Kobayashi, T; Komamura, K; Tachibana, K; Tanaka, K; Ueno, K, 2006)
"Treatment with metoprolol 2 h before the endoscopy has been shown to decrease the incidence of myocardial ischaemia during ERCP."	2.69	Vagal withdrawal during endoscopic retrograde cholangiopancreatography. ( Christensen, M; Rasmussen, V; Rosenberg, J; Schulze, S, 2000)
" A dosing algorithm was used to achieve clinically significant beta-adrenergic blockade."	2.68	Beta blockade to prevent atrial dysrhythmias following coronary bypass surgery. ( Anderson, RP; Guyton, SW; Harvey, E; Holmes, JR; Paull, DL; Tidwell, SL; Woolf, RA, 1997)
"The incidence of arrhythmias was less after metoprolol."	2.67	Effect of pre-operative metoprolol on cardiovascular and catecholamine response and bleeding during hysterectomy. ( Blom, L; Jakobsen, CJ, 1992)
"Metoprolol was therefore found to be useful for treatment of DCM."	2.67	Effects of long-term beta-blockade (metoprolol) therapy in patients with dilated cardiomyopathy. ( Fukuzaki, H; Kawai, H; Kurozumi, H; Nomura, H; Takarada, A; Takeuchi, Y; Tsumura, Y; Yokota, Y, 1991)
"In metoprolol treated patients in whom the arrhythmia frequency was reduced by greater than 75% after three days of treatment, mortality was lower as compared to those metoprolol treated patients who did not show this treatment response (3% vs 28%, P = 0."	2.66	Evaluation of antiarrhythmic effect of metoprolol treatment after acute myocardial infarction: relationship between treatment responses and survival during a 3-year follow-up. ( Olsson, G; Rehnqvist, N, 1986)
"The patients with complex arrhythmias were older (p less than 0."	2.66	Ventricular dysrhythmias in middle-aged hypertensive men treated either with a diuretic agent or a beta-blocker. ( Hardarson, T; Ragnarsson, J; Snorrason, SP, 1987)
"Following withdrawal, ventricular arrhythmias during stress increased in 4 patients in the metoprolol group."	2.66	Cardiovascular reactivity to mental stress during gradual withdrawal of chronic postinfarction treatment with metoprolol. ( Hjemdahl, P; Olsson, G; Rehnqvist, N, 1986)
"Pretreatment with dihydralazine alone attenuated the pressor response to microlaryngoscopy, but was associated with consistently high HR and an incidence of arrhythmias as well as ST60-T changes similar to that found after saline."	2.66	Methohexitone anaesthesia for microlaryngoscopy: circulatory modulation with metoprolol and dihydralazine. ( Magnusson, H; Pontén, J; Sonander, HG, 1986)
"The incidences of congestive heart failure, hypotension, AV blocks and ventricular arrhythmias were not significantly more common in the control group (8 vs."	2.65	Established beta-adrenergic receptor blocking therapy and acute myocardial infarction. A clinical study of risks and benefits. ( Berglund, U; Dahlström, U; Karlsson, E, 1980)
"The incidence of cardiac arrhythmias is estimated et 1."	2.49	[Electrical cardioversion in the treatment of cardiac arrhythmias during pregnancy--case report and review of literature]. ( Gałczyński, K; Kimber-Trojnar, Z; Kudlicki, J; Leszczyńska-Gorzelak, B; Marciniak, B; Oleszczukz, J, 2013)
"Metoprolol is a selective beta(1)-adrenergic antagonist extensively used in major fields of cardiology since 1975."	2.42	[Metoprolol CR/XL: advanced formulation of a classical beta-blocker]. ( Gudkov, KM; Kobalava, ZhD, 2003)
"A novel familial arrhythmia syndrome, cardiac ryanodine receptor (RyR2) calcium release deficiency syndrome (CRDS), has recently been described."	1.72	Provocation Testing and Therapeutic Response in a Newly Described Channelopathy: RyR2 Calcium Release Deficiency Syndrome. ( Chen, SRW; Dreau, HMP; Ginks, MR; Guo, W; Li, Y; McGuire, K; Ormerod, JOM; Ormondroyd, E; Rajappan, K; Sarton, CNS; Taylor, J; Taylor, JC; Wang, R; Watkins, H; Wei, J, 2022)
"Within the COPD GOLD II stage group, there appears to be no statistically significant difference in the number of exacerbations between the patients taking verapamil and digoxin (n = 24) and the patients taking BBs alone (n = 15), although, in patients taking BBs alone, there appears to be a trend towards a decrease in the exacerbations compared to the number of exacerbations in patients taking verapamil and digoxin (p = 0."	1.51	Beta-blocker Use in Moderate and Severe Chronic Obstructive Pulmonary Disease. ( Bedak, O; Begic, E; Bradaric, H; Custovic, F; Durak-Nalbantic, A; Hodzic, E; Mujakovic, A; Prnjavorac, B; Zvizdic, F, 2019)
"Metoprolol was given 20 mg/kg/day for 5 weeks after MI surgery."	1.48	Comparison between renal denervation and metoprolol on the susceptibility of ventricular arrhythmias in rats with myocardial infarction. ( Chen, C; Geng, J; Huo, J; Jiang, W; Jiang, Z; Lu, D; Shan, Q; Xu, H, 2018)
"Colchicine has anti-inflammatory and anti-fibrotic properties."	1.39	An unusual form of Naxos disease and its improvement by adjuvant low-dose colchicine therapy. ( Gultekin, N; Kucukates, E, 2013)
"Idiopathic ventricular tachycardia mostly arises from the right ventricular outflow tract."	1.36	[Idiopathic ventricular tachycardia, an arrhythmia with good prognosis]. ( Bos, HS; Camaro, C; Smeets, JL, 2010)
" Beta-blocker dosages were titrated, and three patients achieved the target beta-blocker dosage established for stage A-C heart failure."	1.34	Tolerability of beta-blockers in outpatients with refractory heart failure who were receiving continuous milrinone. ( Earl, GL; Fitzpatrick, JM; Narula, J; Verbos-Kazanas, MA, 2007)
"Many of the arrhythmias other than ventricular fibrillation had little hemodynamic consequence and did not require treatment."	1.28	Associated reactions during and immediately after rtPA infusion. ( Linnik, W; Ramos, R; Tintinalli, JE, 1989)
"Baseline arrhythmia assessment revealed recurrent ventricular tachycardia in all patients."	1.27	Beta-blocker therapy in patients with ventricular tachyarrhythmias in the setting of left ventricular dysfunction. ( Allen, BJ; Bessen, M; Brodsky, MA; Henry, WL; Luckett, CR; Siddiqi, R, 1988)
"A distinct phase of ventricular arrhythmias was evident about 10 to 30 min after ligation."	1.27	Prevention of ventricular fibrillation by metoprolol in a pig model of acute myocardial ischaemia: absence of a major arrhythmogenic role for cyclic AMP. ( Gihwala, D; Hamm, CW; Muller, CA; Opie, LH; Peisach, M, 1986)
"Ventricular arrhythmias other than VF are common in acute infarction and, for emotional rather than scientific reasons, often are aggressively treated."	1.27	Treatment and prophylaxis of ventricular arrhythmias in acute myocardial infarction. ( Campbell, RW, 1983)
"Metoprolol is a beta 1-adrenoreceptor antagonist which was previously shown to block the teratogenic effects of epinephrine and other catecholamines with beta 1-adrenoreceptor agonist properties."	1.27	Ventricular blood pressure and cardiac output changes in epinephrine- and metoprolol-treated chick embryos. ( Kolesari, GL; Kuhlmann, RS; Rajala, GM; Schnitzler, HJ, 1988)
"Correspondingly, ventricular arrhythmias and fibrillation were almost completely prevented by metoprolol, d-sotalol or verapamil, but increased by lidocaine."	1.27	Comparative investigations on the antiarrhythmic and electrophysiologic effects of class I-IV antiarrhythmic agents following acute coronary artery occlusion. ( Gülker, H; Haverkamp, W; Hindricks, G; Thale, J, 1987)
"The incidence of arrhythmias in the three groups during Caesarean section did not differ significantly."	1.27	[Effect of subpartal tocolysis on maternal cardiovascular parameters with subsequent cesarean section in general anesthesia]. ( Becker, J; Hartung, HJ; Pohl, R; Wiest, W, 1986)
"Mean time to arrhythmia and death was 4."	1.27	The effect of beta blockers on cardiac neural discharge associated with coronary occlusion in the cat. ( Lathers, CM; Spivey, WH, 1987)
"Metoprolol was administered at different times after the onset of ischemia to determine any relationship between antiarrhythmic effects and the time of administration."	1.27	The effect of beta-adrenoceptor blockade and of thromboxane synthetase inhibition, alone and in combination, on arrhythmias resulting from myocardial ischemia. ( Parratt, JR; Wainwright, CL, 1985)
" There were no side-effects related to this cardioselective beta-blocker in the dosage used."	1.26	Intravenous metoprolol and cardiac dysrhythmias. An evaluation in the management of dysrhythmias in outpatient dental anaesthesia. ( Rollason, WN; Russell, JG, 1980)
"The arrhythmias were prevented by higher doses of the calcium antagonist verapamil which, however, decreased the survival times."	1.26	Comparative investigation of the effects of metoprolol, propranolol, practolol, and verapamil in the acute phase of experimental myocardial infarction. ( Bernauer, W, 1982)

Timeframe	Studies, this research(%)	All Research%
pre-1990	63 (48.09)	18.7374
1990's	15 (11.45)	18.2507
2000's	21 (16.03)	29.6817
2010's	26 (19.85)	24.3611
2020's	6 (4.58)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
Cardioprotective Effect of Dexmedetomidine in Patients With ST-segment Elevation Myocardial Infarction: a Double-Blind, Multicenter, Randomized, Placebo-Controlled Clinical Trial[NCT04912518]		250 participants (Anticipated)	Interventional	2021-05-27	Recruiting
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives[NCT04832126]		100 participants (Anticipated)	Observational	2018-01-01	Recruiting
Protective Effect of Statin on Arrhythmia and Heart Rate Variability in Healthy People With 48 Hours of Sleep Deprivation[NCT02496962]		72 participants (Anticipated)	Interventional	2015-07-31	Recruiting
A Single Centre, Retrospective Cohort Study on Post Analysis on the Link Between the Clinical Heart Rate and Outcomes During PCI[NCT02351674]		15,000 participants (Anticipated)	Observational	2015-01-31	Not yet recruiting
Heart Rate Lowering Efficacy and Respiratory Safety of Ivabradine in Patients With Obstructive Airway Disease[NCT01365286]	Phase 4	40 participants (Actual)	Interventional	2009-05-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Practical recommendations for the use of beta-blockers in chronic obstructive pulmonary disease. Expert review of respiratory medicine, 2020, Volume: 14, Issue:7 Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Heart Failure; Humans; Metoprolol; Myocardial Isc	2020
Antiarrhythmic drug-induced smell and taste disturbances: A case report and literature review. Medicine, 2018, Volume: 97, Issue:29 Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dysgeusia; Female; Humans; Metoprolo	2018
[Electrical cardioversion in the treatment of cardiac arrhythmias during pregnancy--case report and review of literature]. Ginekologia polska, 2013, Volume: 84, Issue:10 Topics: Adult; Anti-Arrhythmia Agents; Anticoagulants; Arrhythmias, Cardiac; Digoxin; Electric Countershock;	2013
[Metoprolol CR/XL: advanced formulation of a classical beta-blocker]. Kardiologiia, 2003, Volume: 43, Issue:9 Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Contraindications; Heart Failure; Humans; Hyperte	2003
Beta blockers as anti-arrhythmic agents. Heart failure reviews, 2004, Volume: 9, Issue:2 Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Carbazoles; Carvedilol; H	2004
Resting heart rate in cardiovascular disease. Journal of the American College of Cardiology, 2007, Aug-28, Volume: 50, Issue:9 Topics: Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Calcium Channel Blockers; Carbazoles; Ca	2007
Resting heart rate in cardiovascular disease. Journal of the American College of Cardiology, 2007, Aug-28, Volume: 50, Issue:9 Topics: Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Calcium Channel Blockers; Carbazoles; Ca	2007
Resting heart rate in cardiovascular disease. Journal of the American College of Cardiology, 2007, Aug-28, Volume: 50, Issue:9 Topics: Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Calcium Channel Blockers; Carbazoles; Ca	2007
Resting heart rate in cardiovascular disease. Journal of the American College of Cardiology, 2007, Aug-28, Volume: 50, Issue:9 Topics: Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Calcium Channel Blockers; Carbazoles; Ca	2007
Beta-adrenergic antagonists in the treatment of patients with heart disease. Disease-a-month : DM, 1981, Volume: 27, Issue:9 Topics: Acebutolol; Adrenergic beta-Agonists; Alprenolol; Animals; Arrhythmias, Cardiac; Bronchial Spasm; Ca	1981
Comparative review of beta-blocking agents. Connecticut medicine, 1984, Volume: 48, Issue:4 Topics: Adrenergic beta-Antagonists; Angina Pectoris; Arrhythmias, Cardiac; Atenolol; Humans; Hypertension;	1984
The role of beta-adrenergic receptor antagonists in the prevention of sudden cardiac death. Comprehensive therapy, 1984, Volume: 10, Issue:9 Topics: Action Potentials; Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Calcium; Calcium Channel Block	1984
Drug therapy: metoprolol. The New England journal of medicine, 1979, Sep-27, Volume: 301, Issue:13 Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Disease; Hemodynamics; Humans; Hypertension;	1979
Use of beta adrenoceptor blockade during and after acute myocardial infarction. Annual review of medicine, 1986, Volume: 37 Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Atenolol; Cardiotonic Agents; Clinical Trials as	1986
Metoprolol. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in hypertension, ischaemic heart disease and related cardiovascular disorders. Drugs, 1986, Volume: 31, Issue:5 Topics: Adult; Age Factors; Aged; Arrhythmias, Cardiac; Cardiomegaly; Coronary Disease; Drug Interactions; D	1986

Article	Year
Dynamic Electrocardiogram under P Wave Detection Algorithm Combined with Low-Dose Betaloc in Diagnosis and Treatment of Patients with Arrhythmia after Hepatocarcinoma Resection. Journal of healthcare engineering, 2021, Volume: 2021 Topics: Algorithms; Arrhythmias, Cardiac; Databases, Factual; Electrocardiography; Humans; Metoprolol	2021
Ivabradine vs metoprolol in patients with acute inferior wall myocardial infarction-"Expanding arena for ivabradine". Cardiovascular therapeutics, 2017, Volume: 35, Issue:4 Topics: Adrenergic beta-Antagonists; Adult; Aged; Arrhythmias, Cardiac; Atrioventricular Block; Benzazepines	2017
Early Intravenous Beta-Blockers in Patients With ST-Segment Elevation Myocardial Infarction Before Primary Percutaneous Coronary Intervention. Journal of the American College of Cardiology, 2016, Jun-14, Volume: 67, Issue:23 Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Creatine Kinase; Double-Blind Method; Emergency M	2016
[Effects of carvedilol and metoprolol on expression of autoantibodies against cardiac adrenergic receptors in aged patients with chronic heart failure and ventricular arrhythmia]. Zhonghua xin xue guan bing za zhi, 2010, Volume: 38, Issue:7 Topics: Aged; Aged, 80 and over; Arrhythmias, Cardiac; Autoantibodies; Carbazoles; Carvedilol; Female; Heart	2010
Effects of long-term beta-blocker (metoprolol or carvedilol) therapy on QT variability in subjects with chronic heart failure secondary to ischemic cardiomyopathy. The American journal of cardiology, 2002, Nov-15, Volume: 90, Issue:10 Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Carbazoles; Carvedilol; Female; Heart Failure; Hu	2002
Effect of low-dose metoprolol in combination with sibutramine therapy in normotensive obese patients: a randomized controlled study. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 2004, Volume: 28, Issue:3 Topics: Adrenergic beta-Antagonists; Adult; Anthropometry; Appetite Depressants; Arrhythmias, Cardiac; Cyclo	2004
Effect of amiodarone on the serum concentration/dose ratio of metoprolol in patients with cardiac arrhythmia. Drug metabolism and pharmacokinetics, 2006, Volume: 21, Issue:6 Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cytochrome P-450 CYP2D6; Cyto	2006
Established beta-adrenergic receptor blocking therapy and acute myocardial infarction. A clinical study of risks and benefits. Acta medica Scandinavica, 1980, Volume: 207, Issue:3 Topics: Adrenergic beta-Antagonists; Aged; Alprenolol; Arrhythmias, Cardiac; Clinical Trials as Topic; Femal	1980
beta-Blockers and myocardial infarction. Archives of internal medicine, 1982, Volume: 142, Issue:9 Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Clinical Trials as Topic; Death, Sudden; Diuretic	1982
Ventricular arrhythmias during the first year after acute myocardial infarction: influence of long-term treatment with metoprolol. Circulation, 1984, Volume: 69, Issue:6 Topics: Aged; Arrhythmias, Cardiac; Clinical Trials as Topic; Double-Blind Method; Electrocardiography; Fema	1984
Cardiac dysrhythmia associated with general anaesthesia for oral surgery. Its prevention by the prophylactic use of an oral beta-adrenergic blocker. Anaesthesia, 1983, Volume: 38, Issue:12 Topics: Adult; Anesthesia, Dental; Anesthesia, General; Arrhythmias, Cardiac; Female; Humans; Intraoperative	1983
Göteborg Metoprolol Trial: design, patient characteristics and conduct. The American journal of cardiology, 1984, Jun-25, Volume: 53, Issue:13 Topics: Aged; Arrhythmias, Cardiac; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Electroca	1984
Evaluation of metoprolol in suppressing complex ventricular arrhythmias. The American journal of cardiology, 1983, Volume: 52, Issue:1 Topics: Aged; Arrhythmias, Cardiac; Drug Evaluation; Electrocardiography; Female; Heart Ventricles; Humans;	1983
[The antiarrhythmic effect of metoprolol (author's transl)]. Giornale italiano di cardiologia, 1980, Volume: 10, Issue:3 Topics: Arrhythmias, Cardiac; Clinical Trials as Topic; Humans; Metoprolol; Middle Aged; Placebos; Propanola	1980
Cardiovascular responses to anaesthesia. Influence of beta-adrenoreceptor blockade with metoprolol. Anaesthesia, 1980, Volume: 35, Issue:10 Topics: Adult; Arrhythmias, Cardiac; Blood Pressure; Clinical Trials as Topic; Female; Heart Rate; Hemodynam	1980
Metoprolol in anaesthesia for oral surgery. The effect of pretreatment on the incidence of cardiac dysrhythmias. Anaesthesia, 1980, Volume: 35, Issue:8 Topics: Adolescent; Adult; Anesthesia, Dental; Anesthesia, General; Arrhythmias, Cardiac; Clinical Trials as	1980
Metoprolol treatment after acute myocardial infarction. Effects on ventricular arrhythmias and exercise tests during 6 months. Acta medica Scandinavica, 1981, Volume: 210, Issue:1-2 Topics: Adult; Aged; Arrhythmias, Cardiac; Clinical Trials as Topic; Double-Blind Method; Electrocardiograph	1981
Clinical experience with intravenous metoprolol in supraventricular tachyarrhythmias. A multicentre study. Annals of clinical research, 1981, Volume: 13 Suppl 30 Topics: Adolescent; Adult; Aged; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Clinical Trials	1981
Comparison of perioperative myocardial protection with nifedipine versus nifedipine and metoprolol in patients undergoing elective coronary artery bypass grafting. The Journal of thoracic and cardiovascular surgery, 1995, Volume: 110, Issue:5 Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Calcium Channel Blockers; Coronary Artery Bypass;	1995
Perioperative infusion of nifedipine and metoprolol provides antiischemic and antiarrhythmic protection in patients undergoing elective aortocoronary by-pass surgery. The Journal of cardiovascular surgery, 1994, Volume: 35, Issue:6 Suppl 1 Topics: Arrhythmias, Cardiac; Coronary Artery Bypass; Creatine Kinase; Electrocardiography, Ambulatory; Enda	1994
Combined perioperative infusion of nifedipine and metoprolol provides antiischemic and antiarrhythmic protection in patients undergoing elective aortocoronary bypass surgery. The Thoracic and cardiovascular surgeon, 1993, Volume: 41, Issue:3 Topics: Aged; Arrhythmias, Cardiac; Coronary Artery Bypass; Drug Therapy, Combination; Electrocardiography,	1993
Metoprolol versus sotalol in the treatment of sustained ventricular tachycardia. Journal of cardiovascular pharmacology, 1995, Volume: 26, Issue:4 Topics: Administration, Oral; Adrenergic beta-Antagonists; Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias,	1995
Influence of metoprolol on heart rate variability in survivors of remote myocardial infarction. The American journal of cardiology, 1996, Mar-15, Volume: 77, Issue:8 Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Female; Heart Rate; Humans; Male; Metopro	1996
Beta blockade to prevent atrial dysrhythmias following coronary bypass surgery. American journal of surgery, 1997, Volume: 173, Issue:5 Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Arrhythmias, Ca	1997
Vagal withdrawal during endoscopic retrograde cholangiopancreatography. Scandinavian journal of gastroenterology, 2000, Volume: 35, Issue:1 Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cholangiopancreatography,	2000
Electrophysiological properties of intravenous metoprolol in man. British heart journal, 1978, Volume: 40, Issue:6 Topics: Adult; Arrhythmias, Cardiac; Clinical Trials as Topic; Electrocardiography; Female; Heart Conduction	1978
A comparison of electrophysiologically guided antiarrhythmic drug therapy with beta-blocker therapy in patients with symptomatic, sustained ventricular tachyarrhythmias. The New England journal of medicine, 1992, Oct-01, Volume: 327, Issue:14 Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Death, Sudden, Cardiac; E	1992
Effect of pre-operative metoprolol on cardiovascular and catecholamine response and bleeding during hysterectomy. European journal of anaesthesiology, 1992, Volume: 9, Issue:3 Topics: Administration, Oral; Adult; Anesthesia Recovery Period; Anesthesia, General; Arrhythmias, Cardiac;	1992
Effects of long-term beta-blockade (metoprolol) therapy in patients with dilated cardiomyopathy. Japanese circulation journal, 1991, Volume: 55, Issue:4 Topics: Arrhythmias, Cardiac; Blood Pressure; Cardiomyopathy, Dilated; Echocardiography; Female; Follow-Up S	1991
The effects of metoprolol given early in acute myocardial infarction on ventricular arrhythmias. European heart journal, 1986, Volume: 7, Issue:3 Topics: Administration, Oral; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Clinical Trials as Topic;	1986
Evaluation of antiarrhythmic effect of metoprolol treatment after acute myocardial infarction: relationship between treatment responses and survival during a 3-year follow-up. European heart journal, 1986, Volume: 7, Issue:4 Topics: Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Clinical Trials as	1986
Effect of metoprolol on early exercise-induced ST-segment changes and ventricular arrhythmias in patients with suspected acute myocardial infarction. International journal of cardiology, 1989, Volume: 22, Issue:1 Topics: Arrhythmias, Cardiac; Clinical Trials as Topic; Double-Blind Method; Electrocardiography; Exercise T	1989
Use of beta adrenoceptor blockade during and after acute myocardial infarction. Annual review of medicine, 1986, Volume: 37 Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Atenolol; Cardiotonic Agents; Clinical Trials as	1986
Effect of long term treatment with metoprolol and sotalol on ventricular repolarisation measured by use of transoesophageal atrial pacing. British heart journal, 1986, Volume: 55, Issue:2 Topics: Aged; Arrhythmias, Cardiac; Cardiac Pacing, Artificial; Clinical Trials as Topic; Computers; Double-	1986
Ventricular dysrhythmias in middle-aged hypertensive men treated either with a diuretic agent or a beta-blocker. Acta medica Scandinavica, 1987, Volume: 221, Issue:2 Topics: Aged; Amiloride; Arrhythmias, Cardiac; Bendroflumethiazide; Clinical Trials as Topic; Drug Combinati	1987
Metoprolol in acute myocardial infarction reduces ventricular arrhythmias both in the early stage and after the acute event. International journal of cardiology, 1987, Volume: 15, Issue:3 Topics: Arrhythmias, Cardiac; Clinical Trials as Topic; Double-Blind Method; Female; Heart Ventricles; Human	1987
Cardiovascular reactivity to mental stress during gradual withdrawal of chronic postinfarction treatment with metoprolol. European heart journal, 1986, Volume: 7, Issue:9 Topics: Adult; Aged; Arrhythmias, Cardiac; Blood Pressure; Cardiovascular System; Clinical Trials as Topic;	1986
Methohexitone anaesthesia for microlaryngoscopy: circulatory modulation with metoprolol and dihydralazine. British journal of anaesthesia, 1986, Volume: 58, Issue:9 Topics: Aged; Anesthesia, Intravenous; Arrhythmias, Cardiac; Blood Pressure; Dihydralazine; Female; Heart Ra	1986
Long-term treatment with metoprolol after myocardial infarction: effect on 3 year mortality and morbidity. Journal of the American College of Cardiology, 1985, Volume: 5, Issue:6 Topics: Aged; Angina Pectoris; Arrhythmias, Cardiac; Cerebrovascular Disorders; Clinical Trials as Topic; Co	1985
Metoprolol in acute myocardial infarction. Arrhythmias. The MIAMI Trial Research Group. The American journal of cardiology, 1985, Nov-22, Volume: 56, Issue:14 Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bradycardia; Clinical Trials as Topic; Humans; Metopro	1985
[Metoprolol in acute myocardial infarction--clinical effect and tolerance]. Kardiologia polska, 1985, Volume: 28, Issue:11 Topics: Adult; Aged; Arrhythmias, Cardiac; Clinical Trials as Topic; Female; Humans; Male; Metoprolol; Middl	1985

Article	Year
Provocation Testing and Therapeutic Response in a Newly Described Channelopathy: RyR2 Calcium Release Deficiency Syndrome. Circulation. Genomic and precision medicine, 2022, Volume: 15, Issue:1 Topics: Animals; Arrhythmias, Cardiac; Calcium; Channelopathies; Death, Sudden, Cardiac; Flecainide; Humans;	2022
Effect of metoprolol tartrate tablets and recombinant human B-type natriuretic peptide on the sudden cardiac death and malignant arrhythmias in patients with acute myocardial infarction and heart failure. Pakistan journal of pharmaceutical sciences, 2021, Volume: 34, Issue:6(Special) Topics: Adrenergic beta-1 Receptor Antagonists; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Biomarke	2021
Improved Cardiac Performance and Decreased Arrhythmia in Hypertrophic Cardiomyopathy With Non-β-Blocking R-Enantiomer Carvedilol. Circulation, 2023, Nov-21, Volume: 148, Issue:21 Topics: Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Cardiomyopathy, Hypertrophic; Carvedilol	2023
Beta-blocker Use in Moderate and Severe Chronic Obstructive Pulmonary Disease. Medical archives (Sarajevo, Bosnia and Herzegovina), 2019, Volume: 73, Issue:2 Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bisoprolol; Case-Control	2019
Comparison of carvedilol versus metoprolol in patients with acute myocardial infarction: A protocol for systematic review and meta-analysis. Medicine, 2021, May-21, Volume: 100, Issue:20 Topics: Arrhythmias, Cardiac; Carvedilol; Death, Sudden, Cardiac; Humans; Meta-Analysis as Topic; Metoprolol	2021
Wide Complex Ventricular Rhythm in a Patient After Collapse. JAMA internal medicine, 2017, 06-01, Volume: 177, Issue:6 Topics: Aged, 80 and over; Antihypertensive Agents; Arrhythmias, Cardiac; Bradycardia; Electrocardiography;	2017
β-Blocker Exposure in Pregnancy and Risk of Fetal Cardiac Anomalies. JAMA internal medicine, 2017, 06-01, Volume: 177, Issue:6 Topics: Adrenergic beta-Antagonists; Age Factors; Arrhythmias, Cardiac; Atenolol; Body Mass Index; Californi	2017
Genetic background dominates the susceptibility to ventricular arrhythmias in a murine model of β-adrenergic stimulation. Scientific reports, 2018, 02-02, Volume: 8, Issue:1 Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-Agonists; Animals; Arrhythmias, Cardiac; Gen	2018
Reply. Journal of critical care, 2018, Volume: 45 Topics: Amiodarone; Arrhythmias, Cardiac; Humans; Metoprolol; Propafenone; Shock, Septic	2018
Propafenone for supraventricular arrhythmias in septic shock-Comparison to amiodarone and metoprolol. Journal of critical care, 2018, Volume: 45 Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Humans; Metoprolol; Propafenone; Shock, Se	2018
Comparison of Therapeutic Triiodothyronine Versus Metoprolol in the Treatment of Myocardial Infarction in Rats. Thyroid : official journal of the American Thyroid Association, 2018, Volume: 28, Issue:6 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Echocardiography; Ele	2018
Comparison between renal denervation and metoprolol on the susceptibility of ventricular arrhythmias in rats with myocardial infarction. Scientific reports, 2018, 07-05, Volume: 8, Issue:1 Topics: Animals; Arrhythmias, Cardiac; Connexin 43; Denervation; Disease Models, Animal; Drug Administration	2018
Implications of aging in the treatment of complex arrhythmias. Aging, 2018, 10-27, Volume: 10, Issue:11 Topics: Aging; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Humans; Metoprolol; Propranolol	2018
Differential effects of the β-adrenoceptor blockers carvedilol and metoprolol on SQT1- and SQT2-mutant channels. Journal of cardiovascular electrophysiology, 2013, Volume: 24, Issue:10 Topics: Action Potentials; Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Carbazoles; Carvedilo	2013
β-blockers in congenital short-QT syndrome as ion channel blockers. Journal of cardiovascular electrophysiology, 2013, Volume: 24, Issue:10 Topics: Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Carbazoles; Ether-A-Go-Go Potassium Chan	2013
An unusual form of Naxos disease and its improvement by adjuvant low-dose colchicine therapy. Acta cardiologica, 2013, Volume: 68, Issue:4 Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Arrhythmogenic Right Ventricular Dysplasia; Colchicine	2013
Critical conversations after coronary artery bypass grafting: balancing the evidence and dealing with uncertainty. Circulation. Cardiovascular quality and outcomes, 2014, Volume: 7, Issue:5 Topics: Antihypertensive Agents; Arrhythmias, Cardiac; Coronary Artery Bypass; Evidence-Based Medicine; Huma	2014
Safety of an i.v. β-adrenergic blockade protocol for heart rate optimization before coronary CT angiography. AJR. American journal of roentgenology, 2014, Volume: 203, Issue:4 Topics: Adolescent; Adrenergic beta-1 Receptor Antagonists; Adult; Aged; Aged, 80 and over; Arrhythmias, Car	2014
The effects of diltiazem and metoprolol in QTc prolongation due to amitriptyline intoxication. Human & experimental toxicology, 2016, Volume: 35, Issue:1 Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Cardiovascular Agent	2016
Active cascade screening in primary inherited arrhythmia syndromes: does it lead to prophylactic treatment? Journal of the American College of Cardiology, 2010, Jun-08, Volume: 55, Issue:23 Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cause of Death; Chi-Square Distribution;	2010
Does remodeling of gap junctions and connexin expression contribute to arrhythmogenesis? Study in an immobilization rat model. Circulation journal : official journal of the Japanese Circulation Society, 2010, Volume: 74, Issue:12 Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic beta-1 Receptor Antagonists; Animals; Arrhythmia	2010
[Idiopathic ventricular tachycardia, an arrhythmia with good prognosis]. Nederlands tijdschrift voor geneeskunde, 2010, Volume: 154, Issue:45 Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Arrhythmias, Cardiac; Catheter Ablation; Diagnosis, D	2010
[Inhibitory action of metoprolol and gamma--aminobutyric acid on heart rhythm disorder induced by administration of endothelin-1 into rostral ventrolateral medulla in cats]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2002, Volume: 18, Issue:4 Topics: Animals; Arrhythmias, Cardiac; Cats; Endothelin-1; gamma-Aminobutyric Acid; Medulla Oblongata; Metop	2002
Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release. Nature medicine, 2011, Jul-10, Volume: 17, Issue:8 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bisoprolol; Calcium; Calci	2011
Functional evidence for an active role of B-type natriuretic peptide in cardiac remodelling and pro-arrhythmogenicity. Cardiovascular research, 2012, Jul-01, Volume: 95, Issue:1 Topics: Animals; Arrhythmias, Cardiac; Calcium; Electrocardiography; Heart Failure; Male; Metoprolol; Mice;	2012
Protective effect of metoprolol on arrhythmia and heart rate variability in healthy people with 24 hours of sleep deprivation. Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2013, Volume: 36, Issue:3 Topics: Adolescent; Adult; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiotonic Agents; Female; Heart R	2013
[Effect of metoprolol CR/XL on remodeling of the heart and cardiac rhythm disturbances after myocardial infarction in patients with chronic heart failure]. Kardiologiia, 2003, Volume: 43, Issue:6 Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Drug Therapy, Combination; Female; Heart	2003
[Interrelationship between electrophysiological markers of arrhythmogenicity and psychoemotional status of patients with myocardial infarction]. Kardiologiia, 2003, Volume: 43, Issue:2 Topics: Adrenergic beta-Antagonists; Adult; Aged; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmi	2003
COMET: a proposed mechanism of action to explain the results and concerns about dose. Lancet (London, England), 2003, Sep-27, Volume: 362, Issue:9389 Topics: Adenosine Triphosphatases; Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Carbazoles; Carvedilol	2003
AVID and COMET. Preventive cardiology, 2003,Fall, Volume: 6, Issue:4 Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Carbazoles; Carvedilol; Heart Conduction System;	2003
Effects of autoantibodies against beta(1)-adrenoceptor in hepatitis virus myocarditis on action potential and L-type Ca(2+) currents. World journal of gastroenterology, 2004, Apr-15, Volume: 10, Issue:8 Topics: Action Potentials; Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Autoantibodies; Calci	2004
[Correction of baroreflex sensitivity impairment and efficacy of prevention of sudden arrhythmic death in patients with postinfarction left ventricular dysfunction]. Kardiologiia, 2004, Volume: 44, Issue:10 Topics: Adrenergic beta-Antagonists; Adult; Aged; Amiodarone; Angiotensin-Converting Enzyme Inhibitors; Anti	2004
Chronotropic incompetence as a predictor of death among patients with normal electrograms taking beta blockers (metoprolol or atenolol). The American journal of cardiology, 2005, Nov-01, Volume: 96, Issue:9 Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Atenolol; Cause of Death; Electrocardiography; Ex	2005
Effects of prolonged metoprolol treatment on neural remodeling and inducible ventricular arrhythmias after myocardial infarction in rabbits. International journal of cardiology, 2007, May-02, Volume: 117, Issue:3 Topics: Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Heart Ventricles; Metoprolol; Myocardial	2007
Effects of metoprolol on sympathetic remodeling and electrical remodeling at infarcted border zone after myocardial infarction in rabbits. Cardiology, 2007, Volume: 108, Issue:3 Topics: Action Potentials; Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Female; GAP-43 Protei	2007
Tolerability of beta-blockers in outpatients with refractory heart failure who were receiving continuous milrinone. Pharmacotherapy, 2007, Volume: 27, Issue:5 Topics: Adrenergic beta-Antagonists; Aged; Arrhythmias, Cardiac; Blood Pressure; Carbazoles; Cardiac Output,	2007
Hospitalization rates of generic metoprolol compared with the original beta-blocker in an epidemiological database study. Pharmacoepidemiology and drug safety, 2007, Volume: 16, Issue:12 Topics: Adrenergic beta-Antagonists; Aged; Arrhythmias, Cardiac; Arthritis, Rheumatoid; Databases, Factual;	2007
Clinical trials update from the American Heart Association 2007: CORONA, RethinQ, MASCOT, AF-CHF, HART, MASTER, POISE and stem cell therapy. European journal of heart failure, 2008, Volume: 10, Issue:1 Topics: Adrenergic beta-Antagonists; American Heart Association; Arrhythmias, Cardiac; Atrial Fibrillation;	2008
Clinical use of the beta1-selective adrenoceptor blocker metoprolol in hypertension, angina pectoris and arrhythmias. Annals of clinical research, 1981, Volume: 13 Suppl 30 Topics: Adrenergic beta-Antagonists; Angina Pectoris; Arrhythmias, Cardiac; Humans; Hypertension; Metoprolol	1981
Comparative investigation of the effects of metoprolol, propranolol, practolol, and verapamil in the acute phase of experimental myocardial infarction. Klinische Wochenschrift, 1982, Jan-15, Volume: 60, Issue:2 Topics: Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Blood Pressure; Calcium Channel Blockers	1982
Identification of receptor mechanism mediating epinephrine-induced arrhythmias during halothane anesthesia in the dog. Anesthesiology, 1983, Volume: 59, Issue:4 Topics: Adrenergic alpha-Antagonists; Anesthesia; Animals; Arrhythmias, Cardiac; Dogs; Epinephrine; Halothan	1983
Studies with long acting propranolol. Postgraduate medical journal, 1984, Volume: 60 Suppl 2 Topics: Angina Pectoris; Arrhythmias, Cardiac; Delayed-Action Preparations; Half-Life; Heart Rate; Humans; H	1984
Cardiac dysrhythmias during outpatient dental anaesthesia with enflurane. The role of "beta blockade". Acta anaesthesiologica Scandinavica, 1984, Volume: 28, Issue:5 Topics: Adolescent; Adult; Aged; Ambulatory Surgical Procedures; Anesthesia, Dental; Anesthesia, Inhalation;	1984
Relationship between electrocardiographically estimated infarct size and clinical findings in anterior myocardial infarction. Clinical cardiology, 1984, Volume: 7, Issue:4 Topics: Adult; Aged; Arrhythmias, Cardiac; Electrocardiography; Heart Failure; Humans; Hypotension; Length o	1984
Treatment and prophylaxis of ventricular arrhythmias in acute myocardial infarction. The American journal of cardiology, 1983, Sep-22, Volume: 52, Issue:6 Topics: Arrhythmias, Cardiac; Humans; Lidocaine; Metoprolol; Myocardial Infarction; Resuscitation; Time Fact	1983
Suppression of ventricular ectopy with intravenous metoprolol in patients with chronic obstructive pulmonary disease. Critical care medicine, 1984, Volume: 12, Issue:1 Topics: Aged; Arrhythmias, Cardiac; Drug Evaluation; Electrocardiography; Female; Humans; Injections, Intrav	1984
Electrophysiologic effects of intravenous metoprolol. American heart journal, 1984, Volume: 107, Issue:6 Topics: Adult; Arrhythmias, Cardiac; Atrioventricular Node; Electrocardiography; Female; Heart Conduction Sy	1984
Göteborg Metoprolol Trial: effects on arrhythmias. The American journal of cardiology, 1984, Jun-25, Volume: 53, Issue:13 Topics: Adult; Aged; Arrhythmias, Cardiac; Clinical Trials as Topic; Double-Blind Method; Female; Heart Arre	1984
Protective effect of metoprolol on emetine induced T wave changes in animals. International journal of cardiology, 1984, Volume: 6, Issue:1 Topics: Animals; Arrhythmias, Cardiac; Electrocardiography; Emetine; Metoprolol; Rabbits	1984
Metoprolol in the prevention of dysrhythmias during minor dental surgery. American heart journal, 1983, Volume: 105, Issue:4 Topics: Adolescent; Adult; Aged; Arrhythmias, Cardiac; Dentistry, Operative; Double-Blind Method; Epinephrin	1983
[Prajmalium bitartrate in hyperkinetic ventricular arrhythmias in infarct patients during rehabilitation]. Giornale italiano di cardiologia, 1981, Volume: 11, Issue:6 Topics: Adult; Aged; Ajmaline; Ambulatory Care; Amiodarone; Arrhythmias, Cardiac; Drug Therapy, Combination;	1981
Intravenous metoprolol and cardiac dysrhythmias. An evaluation in the management of dysrhythmias in outpatient dental anaesthesia. Anaesthesia, 1980, Volume: 35, Issue:8 Topics: Adolescent; Adult; Aged; Ambulatory Surgical Procedures; Anesthesia, Dental; Anesthesia, General; Ar	1980
[The effect of treatment with propafenone, metoprolol and amiodarone on lymphocyte sodium efflux and level of cAMP in serum]. Polskie Archiwum Medycyny Wewnetrznej, 1995, Volume: 94, Issue:1 Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cyclic AMP; Female; Heart Dis	1995
Heart conduction disturbances and cardiovascular collapse after disopyramide and low-dose metoprolol in a patient with hypertrophic obstructive cardiomyopathy. Journal of electrocardiology, 1997, Volume: 30, Issue:4 Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Cardiomyopathy, Hypertrophic; Dis	1997
Influence of beta-blockers on the frequency of arrhythmia recurrences in patients with implantable cardioverter-defibrillator: an intraindividual comparison. International journal of cardiology, 1998, Sep-01, Volume: 66, Issue:1 Topics: Adrenergic beta-Antagonists; Aged; Amiodarone; Arrhythmias, Cardiac; Atenolol; Defibrillators, Impla	1998
Beta-adrenergic signalling and threshold adrenaline concentration for induction of fibrillation in the perfused heart pretreated with antihypertensive drugs. Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, 1999, Volume: 199, Issue:3 Topics: Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Cyclic AMP; Enalapril; Epinephrine; GTP-Bind	1999
Side effects of beta-blocker treatment for hypertension. Scandinavian journal of primary health care, 2000, Volume: 18, Issue:2 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Arrhythmias, Cardiac; Dizziness; Female; Heada	2000
Effects of adrenergic beta-blockers and a membrane stabilizing agent on ouabain-induced cardiac arrhythmias in anaesthetized guinea pigs. Acta pharmacologica et toxicologica, 1979, Volume: 45, Issue:2 Topics: Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Guinea Pigs; Lidocaine; Male; Metoprolol	1979
Metoprolol--a new cardioselective beta adrenoceptor antagonist in experimental cardiac arrhythmias. The Indian journal of medical research, 1978, Volume: 68 Topics: Animals; Arrhythmias, Cardiac; Cats; Dogs; Female; Guinea Pigs; Male; Metoprolol; Propanolamines; Pr	1978
Selective beta 1 and beta 2 adrenoceptor blockade on epinephrine-induced arrhythmias in halothane anaesthetized dogs. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1992, Volume: 39, Issue:8 Topics: Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Blood Pressure; Cardiac Complexes, Prema	1992
Isoproterenol and the genesis of reperfusion-induced arrhythmias in isolated rat heart: adrenoceptor or free radical-mediated mechanisms? Journal of cardiovascular pharmacology, 1990, Volume: 15, Issue:3 Topics: Animals; Antioxidants; Arrhythmias, Cardiac; Cardiac Pacing, Artificial; Dose-Response Relationship,	1990
Antiarrhythmic effects of selective beta 1- and beta 2- and nonselective beta-adrenoceptor blockade in normokalaemic and dietary-induced hypokalaemic rats. Journal of cardiovascular pharmacology, 1989, Volume: 14, Issue:5 Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure;	1989
Associated reactions during and immediately after rtPA infusion. Annals of emergency medicine, 1989, Volume: 18, Issue:3 Topics: Arrhythmias, Cardiac; Drug Hypersensitivity; Drug Therapy, Combination; Emergencies; Hemorrhage; Hum	1989
[Multicenter clinical trial on the prevention of sudden death after myocardial infarction by the use of anti-arrhythmia agents. Investigator Group of the Spanish Study on Sudden Death]. Revista espanola de cardiologia, 1989, Volume: 42, Issue:2 Topics: Amiodarone; Arrhythmias, Cardiac; Captopril; Death, Sudden; Humans; Metoprolol; Multicenter Studies	1989
Ginkgolide B protects isolated hearts against arrhythmias induced by ischemia but not reperfusion. European journal of pharmacology, 1989, May-19, Volume: 164, Issue:2 Topics: Animals; Arrhythmias, Cardiac; Diltiazem; Diterpenes; Ginkgolides; Heart Function Tests; Lactones; M	1989
The effect of beta blockers on cardiac neural discharge associated with coronary occlusion in the cat. Journal of clinical pharmacology, 1987, Volume: 27, Issue:8 Topics: Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Blood Pressure; Cats; Coronary Disease;	1987
Beta-blocker therapy in patients with ventricular tachyarrhythmias in the setting of left ventricular dysfunction. American heart journal, 1988, Volume: 115, Issue:4 Topics: Adrenergic beta-Antagonists; Adult; Aged; Arrhythmias, Cardiac; Electrocardiography; Female; Heart F	1988
Prevention of ventricular fibrillation by metoprolol in a pig model of acute myocardial ischaemia: absence of a major arrhythmogenic role for cyclic AMP. Journal of molecular and cellular cardiology, 1986, Volume: 18, Issue:4 Topics: Acute Disease; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Blood Pressure; Coronary Circu	1986
Ventricular blood pressure and cardiac output changes in epinephrine- and metoprolol-treated chick embryos. Teratology, 1988, Volume: 38, Issue:3 Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Cardiac Output; Chick Embryo; Epinephrine; Female; Fe	1988
Comparative investigations on the antiarrhythmic and electrophysiologic effects of class I-IV antiarrhythmic agents following acute coronary artery occlusion. European heart journal, 1987, Volume: 8 Suppl G Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Disease; Dogs; Female; Heart Conduct	1987
Observations with metoprolol in elderly patients. Therapia Hungarica (English edition), 1987, Volume: 35, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Female; Humans; Hypertension; Male; Metoprolol	1987
[Effect of subpartal tocolysis on maternal cardiovascular parameters with subsequent cesarean section in general anesthesia]. Geburtshilfe und Frauenheilkunde, 1986, Volume: 46, Issue:6 Topics: Adult; Anesthesia, General; Anesthesia, Obstetrical; Arrhythmias, Cardiac; Blood Pressure; Cesarean	1986
Halothane-catecholamine arrhythmias in swine (Sus scrofa). American journal of veterinary research, 1986, Volume: 47, Issue:10 Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Blood Pressure; Epinephrine; Female; Halothane; Heart Rat	1986
Alterations in the arrhythmogenic dose of epinephrine after adrenergic receptor blockade with prazosin, metoprolol, or yohimbine in halothane-xylazine-anesthetized dogs. American journal of veterinary research, 1986, Volume: 47, Issue:1 Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Dogs; Dose-Response Relationship, Drug; Epinephrine; Fema	1986
Electrophysiological effects of felodipine in combination with metoprolol. Drugs, 1985, Volume: 29 Suppl 2 Topics: Adult; Aged; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Blood Pressure;	1985
Ambulatory monitoring of blood pressure and arrhythmias by non-invasive methods in hypertensive patients treated with metoprolol. Clinical and experimental hypertension. Part A, Theory and practice, 1985, Volume: 7, Issue:2-3 Topics: Ambulatory Care; Arrhythmias, Cardiac; Blood Pressure; Blood Pressure Determination; Electrocardiogr	1985
The effect of beta-adrenoceptor blockade and of thromboxane synthetase inhibition, alone and in combination, on arrhythmias resulting from myocardial ischemia. Advances in myocardiology, 1985, Volume: 6 Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Coronary Disease; Drug Administration Schedule; Drug	1985
The effects of metoprolol and dazmegrel, alone and in combination, on arrhythmias induced by coronary artery occlusion in conscious rats. British journal of pharmacology, 1985, Volume: 86, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Vessels; Drug Interactions; Heart Ra	1985
Induction of delayed repolarization during chronic beta-receptor blockade. European heart journal, 1985, Volume: 6 Suppl D Topics: Aged; Angina Pectoris; Arrhythmias, Cardiac; Electrocardiography; Heart Conduction System; Heart Rat	1985

metoprolol and Arrhythmia

Research Excerpts

Research

Studies (131)

Authors

Clinical Trials (5)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Jiang, F	1
Xu, H	2
Shi, X	1
Han, B	1
Chu, Z	1
Xu, B	1
Liu, X	1
Ormerod, JOM	1
Ormondroyd, E	1
Li, Y	3
Taylor, J	1
Wei, J	1
Guo, W	1
Wang, R	2
Sarton, CNS	1
McGuire, K	1
Dreau, HMP	1
Taylor, JC	1
Ginks, MR	1
Rajappan, K	1
Chen, SRW	1
Watkins, H	1
Liu, C	1
Yao, L	1
Zhang, L	2
Lin, Y	1
Seo, K	1
Yamamoto, Y	1
Kirillova, A	1
Kawana, M	1
Yadav, S	1
Huang, Y	1
Wang, Q	2
Lane, KV	1
Pruitt, BL	1
Perez, MV	1
Bernstein, D	1
Wu, JC	1
Wheeler, MT	1
Parikh, VN	1
Ashley, EA	1
Zvizdic, F	1
Begic, E	1
Mujakovic, A	1
Hodzic, E	1
Prnjavorac, B	1
Bedak, O	1
Custovic, F	1
Bradaric, H	1
Durak-Nalbantic, A	1
Wade, C	1
Wells, JM	1
Zhang, JG	1
Dai, SP	1
Liu, H	1
Xu, ZS	1
Muniyappa, A	1
Goldschlager, N	1
Duan, L	1
Ng, A	1
Chen, W	2
Spencer, HT	1
Nguyen, J	1
Shen, AY	1
Lee, MS	1
Priti, K	1
Ranwa, BL	1
Gokhroo, RK	1
Kishore, K	1
Bisht, DS	1
Gupta, S	1
Jelinek, M	1
Wallach, C	1
Ehmke, H	1
Schwoerer, AP	1
Balik, M	1
Maly, M	1
Brozek, T	1
Brestovansky, P	1
Khoury, J	1
Azzam, ZS	1
Zhang, K	1
Tang, YD	1
Zhang, Y	1
Ojamaa, K	1
Saini, AS	1
Carrillo-Sepulveda, MA	1
Rajagopalan, V	1
Gerdes, AM	1
Jiang, W	1
Chen, C	1
Huo, J	1
Lu, D	1
Jiang, Z	1
Geng, J	1
Shan, Q	1
Che, X	1
Fang, Y	1
Reis, C	1
Wang, H	1
Chatzidou, S	1
Georgiopoulos, G	1
Kontogiannis, C	1
Bodi, I	1
Franke, G	1
Pantulu, ND	1
Wu, K	1
Perez-Feliz, S	1
Bode, C	1
Zehender, M	1
zur Hausen, A	1
Brunner, M	1
Odening, KE	1
Abriel, H	1
Rougier, JS	1
Gultekin, N	1
Kucukates, E	1
Gałczyński, K	1
Marciniak, B	1
Kudlicki, J	1
Kimber-Trojnar, Z	1
Leszczyńska-Gorzelak, B	1
Oleszczukz, J	1
Kassamali, RH	1
Kim, DH	1
Patel, H	1
Raichura, N	1
Hoey, ET	1
Hodson, J	1
Hussain, S	1
Basol, N	1
Erbas, O	1
Roolvink, V	1
Ibáñez, B	1
Ottervanger, JP	1
Pizarro, G	1
van Royen, N	1
Mateos, A	1
Dambrink, JE	1
Escalera, N	1
Lipsic, E	1
Albarran, A	1
Fernández-Ortiz, A	1
Fernández-Avilés, F	1
Goicolea, J	1
Botas, J	1
Remkes, W	1
Hernandez-Jaras, V	1
Kedhi, E	1
Zamorano, JL	1
Navarro, F	1
Alfonso, F	1
García-Lledó, A	1
Alonso, J	1
van Leeuwen, M	1
Nijveldt, R	1
Postma, S	1
Kolkman, E	1
Gosselink, M	1
de Smet, B	1
Rasoul, S	1
Piek, JJ	1
Fuster, V	1
van 't Hof, AWJ	1
Hofman, N	1
Tan, HL	1
Alders, M	1
van Langen, IM	1
Wilde, AA	1
Li, XD	1
Wang, JC	1
Ye, L	1
Zhao, Y	1
Zhou, NN	1
Zhu, X	1
Hayashi, H	1
Camaro, C	1
Bos, HS	1
Smeets, JL	1
Yang, XL	1
Fu, WJ	1
Xu, SL	1
Zhou, Q	1
Xiao, J	1
Jiang, D	1
Vembaiyan, K	1
Wang, A	1
Smith, CD	1
Xie, C	1
Zhang, J	1
Tian, X	1
Jones, PP	1
Zhong, X	1
Guo, A	1
Chen, H	1
Zhu, W	1
Yang, D	1
Li, X	1
Chen, J	1
Gillis, AM	2
Duff, HJ	1
Cheng, H	1
Feldman, AM	1
Song, LS	1
Fill, M	1
Back, TG	1
Chen, SR	1
Thireau, J	1
Karam, S	1
Fauconnier, J	1
Roberge, S	1
Cassan, C	1
Cazorla, O	1
Aimond, F	1
Lacampagne, A	1
Babuty, D	1
Richard, S	1
Chen, WR	1
Shi, XM	1
Yang, TS	1
Zhao, LC	1
Gao, LG	1
Piccirillo, G	1
Quaglione, R	1
Nocco, M	1
Naso, C	1
Moisè, A	1
Lionetti, M	1
Di Carlo, S	1
Marigliano, V	1
Syrkin, AL	1
Poltavskaia, MG	1
Shumilova, KM	1
Ivanov, GG	1
Churganova, LIu	1
Sheianov, MV	1
Gavril'eva, SA	1
Lebedeva, NB	1
Lebedev, OV	1
Berns, SA	1
Barbarash, LS	1
Barbarash, NA	1
Barbarash, OL	1
Coca, SG	1
Buller, GK	1
Kobalava, ZhD	1
Gudkov, KM	1
Liebson, PR	1
Ersoz, HO	1
Ukinc, K	1
Baykan, M	1
Erem, C	1
Durmus, I	1
Hacihasanoglu, A	1
Telatar, M	1
Liu, K	1
Liao, YH	1
Wang, ZH	1
Li, SL	1
Wang, M	1
Zeng, LL	1
Tang, M	1
Kanopskiĭ, SG	1
Staritskiĭ, AG	1
Bozhko, AA	1
Anh, D	1
Marine, JE	1
Khan, MN	1
Pothier, CE	1
Lauer, MS	1
Yan, SH	1
Hu, HS	1
Wang, XL	1
Xing, QC	1
Shi, CW	1
Cheng, WJ	1
Xue, M	1
Jiang, H	1
Lu, Z	1
Yu, Y	1
Zhao, D	1
Jian, X	1
Yang, B	1
Huang, C	1
Fukumoto, K	1
Kobayashi, T	1
Tachibana, K	1
Kato, R	1
Tanaka, K	1
Komamura, K	1
Kamakura, S	1
Kitakaze, M	1
Ueno, K	1
Earl, GL	1
Verbos-Kazanas, MA	1
Fitzpatrick, JM	1
Narula, J	1
Fox, K	1
Borer, JS	2
Camm, AJ	1
Danchin, N	1
Ferrari, R	1
Lopez Sendon, JL	1
Steg, PG	1
Tardif, JC	1
Tavazzi, L	1
Tendera, M	1
Ahrens, W	1
Hagemeier, C	1
Mühlbauer, B	1
Pigeot, I	1
Püntmann, I	1
Reineke, A	1
Steinbach, M	1
Timm, J	1
Cleland, JG	1
Coletta, AP	1
Abdellah, AT	1
Cullington, D	1
Clark, AL	1
Rigby, AS	1
Dahlström, U	1
Berglund, U	1
Karlsson, E	1
Moses, JW	1
Bernauer, W	1
Moser, M	1
Gorlin, R	1
Maze, M	1
Smith, CM	1
Jackson, EA	1
Sullman, SA	1
Clusin, WT	1
Olsson, G	6
Rehnqvist, N	7
Shanks, RG	1
Rollason, WN	2
Bennetts, FE	1
Clarke, I	1
Herlitz, J	3
Hjalmarson, A	3
Campbell, RW	1
Hanna, MH	1
Heap, DG	1
Kimberley, AP	1
Fenster, PE	1
Quan, SF	1
Hanson, CD	1
Coaker, LA	1
Marchlinski, FE	1
Buxton, AE	1
Waxman, HL	1
Josephson, ME	1
Edvardsson, N	3
Holmberg, S	2
Rydén, L	1
Waagstein, F	2
Waldenström, A	2
Swedberg, K	2
Pennert, K	1
Vedin, A	1
Waldenström, J	1
Wedel, H	1
Wilhelmsen, L	1
Mittal, SR	1
Mathur, AK	1
Sharma, SK	1
Ward-Booth, P	1
Rubin, P	1
Macfarlane, P	1
Hillis, S	1
Pratt, CM	1
Yepsen, SC	1
Bloom, MG	1
Taylor, AA	1
Young, JB	1
Quinones, MA	1
Bolognesi, R	1
Bruno, G	1
Burani, G	1
Codecá, L	1
Effendy, FN	1
Gruppillo, P	1
Coleman, AJ	1
Jordan, C	1
Whitehead, MH	1
Whitmarsh, VB	1
Horton, JN	1
Lundman, T	2
Melcher, A	1
Molinis, G	1
Valente, M	1
Tuniz, D	1
Maisano, G	1
Russell, JG	1
Podesser, BK	1
Schwarzacher, S	3
Zwoelfer, W	1
Binder, TM	2
Wolner, E	2
Seitelberger, R	3
Podesser, B	2
Zwölfer, W	2
Binder, T	1
Spatt, J	2
Peschl, F	2
Huber, S	2
Kosmala, W	1
Antz, M	1
Cappato, R	1
Kuck, KH	1
Keeley, EC	1
Page, RL	1
Lange, RA	1
Willard, JE	1
Landau, C	1
Hillis, LD	1
Paull, DL	1
Tidwell, SL	1
Guyton, SW	1
Harvey, E	1
Woolf, RA	1
Holmes, JR	1
Anderson, RP	1
Pernat, A	1
Pohar, B	1
Horvat, M	1
Fries, R	1
Heisel, A	1
Schieffer, H	1
Gordeladze, JO	1
Sellevold, OF	1
Jynge, P	1
Christensen, M	1
Rasmussen, V	1
Schulze, S	1
Rosenberg, J	1
Kumpusalo, E	1
Pärnänen, H	1
Takala, J	1
Aberg, G	1
Adler, G	1
Duker, G	1
Ek, B	1
Telemo, E	1
Koch-Weser, J	1
Rizzon, P	1
Di Biase, M	1
Chiddo, A	1
Mastrangelo, D	1
Sorgente, L	1
Sivam, SP	1
Seth, SD	1
Hayashi, Y	1
Sumikawa, K	1
Kamibayashi, T	1
Yamatodani, A	1
Mammoto, T	1
Kuro, M	1
Yoshiya, I	1
Steinbeck, G	1
Andresen, D	1
Bach, P	1
Haberl, R	1
Oeff, M	1
Hoffmann, E	1
von Leitner, ER	1
Jakobsen, CJ	1
Blom, L	1
Tosaki, A	2
Woodward, B	1
Yamamoto, F	1
Hearse, DJ	1
Yokota, Y	1
Nomura, H	1
Kawai, H	1
Tsumura, Y	1
Takeuchi, Y	1
Kurozumi, H	1
Takarada, A	1
Fukuzaki, H	1
Murray, DP	1
Murray, RG	1
Littler, WA	1
Winslow, E	1
Walker, G	1
Mason, R	1
Linnik, W	1
Tintinalli, JE	1
Ramos, R	1
Rønnevik, PK	1
Gundersen, T	1
Abrahamsen, AM	1
Knutsen, H	1
Woie, L	1
Koltai, M	1
Hosford, D	1
Braquet, P	1
Sleight, P	1
Lathers, CM	1
Spivey, WH	1
Brodsky, MA	1
Allen, BJ	1
Bessen, M	1
Luckett, CR	1
Siddiqi, R	1
Henry, WL	1
Benfield, P	1
Clissold, SP	1
Brogden, RN	1
Muller, CA	1
Opie, LH	1
Hamm, CW	1
Peisach, M	1
Gihwala, D	1
Blomström-Lundqvist, C	1
Dohnal, M	1
Hirsch, I	1
Lindblad, A	1
Olsson, SB	2
Rajala, GM	1
Kolesari, GL	1
Kuhlmann, RS	1
Schnitzler, HJ	1
Ragnarsson, J	1
Hardarson, T	1
Snorrason, SP	1
Erhardt, L	2
Ekman, AM	1
Thale, J	1
Haverkamp, W	1
Hindricks, G	1
Gülker, H	1
Szabó, R	1
Kohán, M	1
Gyetvai, A	1
Szöllösi, K	1
Hjemdahl, P	1
Pohl, R	1
Wiest, W	1
Hartung, HJ	1
Becker, J	1
Magnusson, H	1
Pontén, J	1
Sonander, HG	1
Tranquilli, WJ	2
Thurmon, JC	2
Benson, GJ	2
Sjögren, A	1
Dłuzniewski, M	1
Jurgiel, R	1
Budaj, A	1
Jones, CR	1
Rae, AP	1
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de Vane, PJ	1
Jamieson, RR	1
Hornung, RS	1
Hillis, WS	1
Palma, JL	1
Codina, J	1
Wainwright, CL	2
Parratt, JR	2
Leprán, I	1
Szekeres, L	1