Page last updated: 2024-10-31

metoprolol and Aging

metoprolol has been researched along with Aging in 36 studies

Metoprolol: A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
metoprolol : A propanolamine that is 1-(propan-2-ylamino)propan-2-ol substituted by a 4-(2-methoxyethyl)phenoxy group at position 1.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Metoprolol is a β-adrenergic receptor antagonist that is ineffective in younger patients, but may benefit older (≥40 years) VVS patients."6.82Rationale for the Assessment of Metoprolol in the Prevention of Vasovagal Syncope in Aging Subjects Trial (POST5). ( Benditt, DG; Faris, PD; Krahn, AD; Manns, B; Morillo, CA; Raj, SR; Semeniuk, L; Sheldon, RS, 2016)
" The mean hepatic clearances determined by in silico fitting for individual pharmacokinetic models of warfarin and midazolam in the aged group were, respectively, 23% and 56% smaller than those for the young group."5.48Effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome P450 probes caffeine, warfarin, omeprazole, metoprolol and midazolam in common marmosets genotyped for cytochrome P450 2C19. ( Inoue, T; Kusama, T; Mogi, M; Sasaki, E; Shimizu, M; Toda, A; Uehara, S; Uno, Y; Utoh, M; Yamazaki, H, 2018)
" administration of racemic metoprolol in the rat, the plasma concentrations of (R)- and (S)-metoprolol were comparable, and no differences in pharmacokinetic parameters between the two enantiomers were found."5.29Aging and the pharmacokinetics and metabolism of metoprolol enantiomers in the rat. ( Belpaire, FM; Bogaert, MG; De Smet, F; Vercruysse, I; Vermeulen, AM, 1993)
" administration of the beta blockers, no significant increase in area under the plasma drug concentration-time curve was observed for propranolol and metoprolol as a function of age, but for atenolol, a significant increase in area under the plasma drug concentration-time curve was seen in the 24-month-old rats, due to a decrease in renal function, as bioavailability of atenolol did not change in function of age."5.28Effect of aging on the pharmcokinetics of atenolol, metoprolol and propranolol in the rat. ( Belpaire, FM; Bogaert, MG; Chauvelot-Moachon, L; de Smet, F; Rosseel, MT; Vermeulen, AM; Vynckier, LJ, 1990)
" The effects of aging on the responsiveness of the isolated pacemaker of the rat to the chronotropic effect of norepinephrine, isoproterenol and soterenol were studied."3.68Subsensitivity to beta-adrenoceptor agonists in pacemakers isolated from senescent rats. ( de Moraes, S; Spadari, RC, 1991)
"Metoprolol is a β-adrenergic receptor antagonist that is ineffective in younger patients, but may benefit older (≥40 years) VVS patients."2.82Rationale for the Assessment of Metoprolol in the Prevention of Vasovagal Syncope in Aging Subjects Trial (POST5). ( Benditt, DG; Faris, PD; Krahn, AD; Manns, B; Morillo, CA; Raj, SR; Semeniuk, L; Sheldon, RS, 2016)
" They were submitted to clinical exam, stress testing and plasma lipids dosage before and after four weeks of treatment."2.66[Effect of beta blockers with intrinsic sympathomimetic activity on blood pressure and blood lipids in patients with essential hypertension]. ( Bellotti, G; Braga, A; Pileggi, F; Santomauro, A; Serro-Azul, JB; Serro-Azul, LG; Wajngarten, M; Yazbek Júnior, P, 1989)
"Heart failure is associated with increased sympathetic nervous stimulation that results in down-regulation of myocardial beta-1 receptors."2.42Myocardial beta-1 adrenoceptor down-regulation in aging and heart failure: implications for beta-blocker use in older adults with heart failure. ( Ahmed, A, 2003)
" The mean hepatic clearances determined by in silico fitting for individual pharmacokinetic models of warfarin and midazolam in the aged group were, respectively, 23% and 56% smaller than those for the young group."1.48Effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome P450 probes caffeine, warfarin, omeprazole, metoprolol and midazolam in common marmosets genotyped for cytochrome P450 2C19. ( Inoue, T; Kusama, T; Mogi, M; Sasaki, E; Shimizu, M; Toda, A; Uehara, S; Uno, Y; Utoh, M; Yamazaki, H, 2018)
"Treatment with metoprolol decreased systolic blood pressure at 21 months only but improved survival, decreased ventricular weight, prevented chamber dilation, reduced inflammation, decreased fibrosis, attenuated action potential prolongation, improved systolic and diastolic function, decreased stiffness and improved endothelium-independent vascular responses."1.37Chronic β-adrenoceptor antagonist treatment controls cardiovascular remodeling in heart failure in the aging spontaneously hypertensive rat. ( Brown, L; Chan, V; Fenning, A; Hoey, A, 2011)
"A new, once-daily combination tablet containing felodipine and metoprolol has been developed, using extended-release techniques to obtain even plasma concentrations throughout the dosing interval."1.29Design and pharmacokinetics of Logimax, a new extended-release combination tablet of felodipine and metoprolol. ( Abrahamsson, B; Edgar, B; Lidman, K; Wingstrand, K, 1993)
" administration of the beta blockers, no significant increase in area under the plasma drug concentration-time curve was observed for propranolol and metoprolol as a function of age, but for atenolol, a significant increase in area under the plasma drug concentration-time curve was seen in the 24-month-old rats, due to a decrease in renal function, as bioavailability of atenolol did not change in function of age."1.28Effect of aging on the pharmcokinetics of atenolol, metoprolol and propranolol in the rat. ( Belpaire, FM; Bogaert, MG; Chauvelot-Moachon, L; de Smet, F; Rosseel, MT; Vermeulen, AM; Vynckier, LJ, 1990)
" 3 Areas under the plasma concentration curve for metoprolol after repeated administration are greater than would be predicted from single dose data, and possible explanations for this are discussed."1.26The effect of age on the pharmacokinetics of metoprolol and its metabolites. ( Jack, DB; Kendall, MJ; Quarterman, CP, 1981)
"Propranolol did not cause this pressor effect in prehypertensive (seven week old) SHRs."1.26Beta-adrenergic receptor blocking drugs in spontaneous hypertension. ( Levy, JV, 1976)

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-199010 (27.78)18.7374
1990's11 (30.56)18.2507
2000's6 (16.67)29.6817
2010's8 (22.22)24.3611
2020's1 (2.78)2.80

Authors

AuthorsStudies
Tran, T1
Mach, J1
Gemikonakli, G1
Wu, H1
Allore, H1
Howlett, SE1
Little, CB1
Hilmer, SN1
Toda, A1
Uehara, S1
Inoue, T1
Utoh, M1
Kusama, T1
Shimizu, M1
Uno, Y1
Mogi, M1
Sasaki, E1
Yamazaki, H1
Chatzidou, S1
Georgiopoulos, G1
Kontogiannis, C1
Bratt, EL1
Östman-Smith, I1
Sun, Y1
Wang, Y1
Zhang, L1
Xu, C1
Liu, Y1
Kang, S1
Yan, C1
Li, D1
Sun, H1
Raj, SR1
Faris, PD1
Semeniuk, L1
Manns, B1
Krahn, AD1
Morillo, CA1
Benditt, DG1
Sheldon, RS1
Chudzik, M1
Maciążek-Jurczyk, M1
Pawełczak, B1
Sułkowska, A1
Chan, V1
Fenning, A1
Hoey, A1
Brown, L1
Fedorets, VN1
Dorne, JL1
Walton, K1
Slob, W1
Renwick, AG1
Ahmed, A1
Schutzer, WE1
Xue, H1
Reed, JF1
Mader, SL1
Leosco, D1
Rengo, G1
Iaccarino, G1
Filippelli, A1
Lymperopoulos, A1
Zincarelli, C1
Fortunato, F1
Golino, L1
Marchese, M1
Esposito, G1
Rapacciuolo, A1
Rinaldi, B1
Ferrara, N1
Koch, WJ1
Rengo, F1
Funovic, P1
Korda, M1
Kubant, R1
Barlag, RE1
Jacob, RF1
Mason, RP1
Malinski, T1
Clark, DW1
Morgan, AK1
Waal-Manning, H1
Quarterman, CP1
Kendall, MJ2
Jack, DB1
de Champlain, J1
Cousineau, D1
Lapointe, L1
Suh, YH1
Lee, IS1
Kim, SS1
Choi, W1
Park, CW1
Chung, MH1
Lim, JK1
Abrahamsson, B1
Edgar, B1
Lidman, K1
Wingstrand, K1
Ljungman, S1
Wikstrand, J3
Hartford, M1
Aurell, M1
Lindstedt, G1
Berglund, G1
Vermeulen, AM2
Belpaire, FM2
De Smet, F2
Vercruysse, I1
Bogaert, MG2
Lane, CD1
Wan, J1
Xie, YH1
Xia, H1
Lu, YQ1
Lindahl, A1
Krondahl, E1
Grudén, AC1
Ungell, AL1
Lennernäs, H1
Fujii, K1
Onaka, U1
Goto, K1
Abe, I1
Fujishima, M1
Shi, X1
Wray, DW1
Formes, KJ1
Wang, HW1
Hayes, PM1
O-Yurvati, AH1
Weiss, MS1
Reese, IP1
Levy, JV1
Watson, RD1
Stallard, TJ1
Littler, WA1
Brown, D1
Yates, RA1
Spadari, RC1
de Moraes, S1
Vanscheeuwijck, P1
Van de Velde, E1
Fraeyman, N1
Vynckier, LJ1
Rosseel, MT1
Chauvelot-Moachon, L1
Elfellah, MS1
Dalling, R1
Kantola, IM1
Reid, JL1
Serro-Azul, JB1
Wajngarten, M1
Santomauro, A1
Braga, A1
Yazbek Júnior, P1
Bellotti, G1
Serro-Azul, LG1
Pileggi, F1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Assessment of Metoprolol in the Prevention of Vasovagal Syncope in Aging Subjects[NCT02123056]Phase 452 participants (Actual)Interventional2014-10-31Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for metoprolol and Aging

ArticleYear
Myocardial beta-1 adrenoceptor down-regulation in aging and heart failure: implications for beta-blocker use in older adults with heart failure.
    European journal of heart failure, 2003, Volume: 5, Issue:6

    Topics: Adrenergic beta-Antagonists; Aging; Carbazoles; Carvedilol; Down-Regulation; Heart Failure; Hemodyna

2003
New concepts in the treatment of elderly hypertensive patients.
    American heart journal, 1988, Volume: 116, Issue:1 Pt 2

    Topics: Aged; Aging; Antihypertensive Agents; Clinical Trials as Topic; Heart Failure; Heart Ventricles; Hum

1988

Trials

3 trials available for metoprolol and Aging

ArticleYear
Rationale for the Assessment of Metoprolol in the Prevention of Vasovagal Syncope in Aging Subjects Trial (POST5).
    American heart journal, 2016, Volume: 174

    Topics: Administration, Oral; Adrenergic beta-Antagonists; Adult; Aged; Aging; Dose-Response Relationship, D

2016
[Effect of beta blockers with intrinsic sympathomimetic activity on blood pressure and blood lipids in patients with essential hypertension].
    Arquivos brasileiros de cardiologia, 1989, Volume: 53, Issue:6

    Topics: Aging; Blood Pressure; Clinical Trials as Topic; Exercise Test; Female; Heart Rate; Humans; Hyperten

1989
New concepts in the treatment of elderly hypertensive patients.
    American heart journal, 1988, Volume: 116, Issue:1 Pt 2

    Topics: Aged; Aging; Antihypertensive Agents; Clinical Trials as Topic; Heart Failure; Heart Ventricles; Hum

1988

Other Studies

32 other studies available for metoprolol and Aging

ArticleYear
Diurnal effects of polypharmacy with high drug burden index on physical activities over 23 h differ with age and sex.
    Scientific reports, 2022, 02-09, Volume: 12, Issue:1

    Topics: Age Factors; Aging; Animals; Behavior, Animal; Cholinergic Antagonists; Circadian Rhythm; Explorator

2022
Effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome P450 probes caffeine, warfarin, omeprazole, metoprolol and midazolam in common marmosets genotyped for cytochrome P450 2C19.
    Xenobiotica; the fate of foreign compounds in biological systems, 2018, Volume: 48, Issue:7

    Topics: Administration, Intravenous; Aging; Animals; Caffeine; Callithrix; Cytochrome P-450 CYP2C19; Genotyp

2018
Implications of aging in the treatment of complex arrhythmias.
    Aging, 2018, 10-27, Volume: 10, Issue:11

    Topics: Aging; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Humans; Metoprolol; Propranolol

2018
Effects of lifestyle changes and high-dose β-blocker therapy on exercise capacity in children, adolescents, and young adults with hypertrophic cardiomyopathy.
    Cardiology in the young, 2015, Volume: 25, Issue:3

    Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aging; Blood Pressure; Cardiomyopathy, Hypertrophic,

2015
Prevention of cardiac events caused by surgical stress in aged rats: simultaneously activating β2-adrenoceptor and inhibiting β1-adrenoceptor.
    Stress (Amsterdam, Netherlands), 2014, Volume: 17, Issue:4

    Topics: Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Antagonists; Aging; Animals; Cardiac Surgical P

2014
Spectroscopic Studies on the Molecular Ageing of Serum Albumin.
    Molecules (Basel, Switzerland), 2016, Dec-27, Volume: 22, Issue:1

    Topics: Aging; Animals; Binding Sites; Cattle; Circular Dichroism; Computer Simulation; Humans; Metoprolol;

2016
Chronic β-adrenoceptor antagonist treatment controls cardiovascular remodeling in heart failure in the aging spontaneously hypertensive rat.
    Journal of cardiovascular pharmacology, 2011, Volume: 58, Issue:4

    Topics: Adrenergic beta-1 Receptor Antagonists; Aging; Animals; Blood Pressure; Disease Models, Animal; Dose

2011
[Ischemic heart disease in elderly patients of behavioral type A (psychosocial and clinic functional changes, possibilities for correction)].
    Advances in gerontology = Uspekhi gerontologii, 2011, Volume: 24, Issue:1

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Aging; Anti-Anxiety Agents; Behavioral Symptoms; Benzodiaz

2011
Human variability in polymorphic CYP2D6 metabolism: is the kinetic default uncertainty factor adequate?
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2002, Volume: 40, Issue:11

    Topics: Adult; Aged; Aging; Benzhydryl Compounds; Cresols; Cyclohexanols; Cytochrome P-450 CYP2D6; Debrisoqu

2002
Effect of age on vascular beta2-adrenergic receptor desensitization is not mediated by the receptor coupling to Galphai proteins.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2006, Volume: 61, Issue:9

    Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aging; Animals; Aorta; GTP

2006
Exercise training and beta-blocker treatment ameliorate age-dependent impairment of beta-adrenergic receptor signaling and enhance cardiac responsiveness to adrenergic stimulation.
    American journal of physiology. Heart and circulatory physiology, 2007, Volume: 293, Issue:3

    Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aging; Animals; Blood Pres

2007
Effect of beta-blockers on endothelial function during biological aging: a nanotechnological approach.
    Journal of cardiovascular pharmacology, 2008, Volume: 51, Issue:2

    Topics: Adrenergic beta-Antagonists; Aging; Animals; Aorta, Thoracic; Arginine; Atenolol; Cellular Senescenc

2008
Adverse effects from metoprolol are not generally associated with oxidation status.
    British journal of clinical pharmacology, 1984, Volume: 18, Issue:6

    Topics: Aging; Antibodies, Antinuclear; Female; Humans; Male; Metoprolol; Oxidation-Reduction; Sex Factors;

1984
The effect of age on the pharmacokinetics of metoprolol and its metabolites.
    British journal of clinical pharmacology, 1981, Volume: 11, Issue:3

    Topics: Adolescent; Adult; Aged; Aging; Chemical Phenomena; Chemistry; Female; Humans; Kinetics; Metoprolol;

1981
Evidences supporting an increased sympathetic tone and reactivity in a subgroup of patients with essential hypertension.
    Clinical and experimental hypertension, 1980, Volume: 2, Issue:3-4

    Topics: Adult; Aging; Blood Pressure; Catecholamines; Diagnosis, Differential; Epinephrine; Female; Heart Ra

1980
Ligand binding characteristics of [3H] dihydroalprenolol in cerebral cortical membranes of young and old senescence-accelerated mouse.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1993, Volume: 104, Issue:3

    Topics: Aging; Animals; Cerebral Cortex; Dihydroalprenolol; Male; Metoprolol; Mice; Radioligand Assay; Recep

1993
Design and pharmacokinetics of Logimax, a new extended-release combination tablet of felodipine and metoprolol.
    Blood pressure. Supplement, 1993, Volume: 1

    Topics: Adult; Aged; Aging; Biological Availability; Delayed-Action Preparations; Drug Combinations; Felodip

1993
Effects of long-term antihypertensive treatment and aging on renal function and albumin excretion in primary hypertension.
    American journal of hypertension, 1993, Volume: 6, Issue:7 Pt 1

    Topics: Aging; Albuminuria; Case-Control Studies; Drug Therapy, Combination; Follow-Up Studies; Glomerular F

1993
Aging and the pharmacokinetics and metabolism of metoprolol enantiomers in the rat.
    Journal of gerontology, 1993, Volume: 48, Issue:3

    Topics: Administration, Oral; Aging; Animals; Cytochrome P-450 Enzyme System; Half-Life; In Vitro Techniques

1993
Sudden unexpected death in young adult due to right ventricular dysplasia.
    Journal of forensic sciences, 1997, Volume: 42, Issue:1

    Topics: Adult; Aging; Connective Tissue; Death, Sudden; Endocardium; Female; Forensic Medicine; Humans; Inci

1997
Age might influence the frequency distribution of metoprolol hydroxylation polymorphism in a Chinese population.
    Pharmacology & toxicology, 1997, Volume: 80, Issue:4

    Topics: Adolescent; Adult; Aged; Aging; China; Female; Gene Frequency; Humans; Hydroxylation; Male; Metoprol

1997
Is the jejunal permeability in rats age-dependent?
    Pharmaceutical research, 1997, Volume: 14, Issue:9

    Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Atenolol; Glucose; Jejunum; Mal

1997
Impaired isoproterenol-induced hyperpolarization in isolated mesenteric arteries of aged rats.
    Hypertension (Dallas, Tex. : 1979), 1999, Volume: 34, Issue:2

    Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Age Factors; Aging; Animal

1999
Orthostatic hypotension in aging humans.
    American journal of physiology. Heart and circulatory physiology, 2000, Volume: 279, Issue:4

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Aging; Atropine; Blood Pressure; Female; Glycopyrrolate; H

2000
Beta-adrenergic receptor blocking drugs in spontaneous hypertension.
    The American journal of medicine, 1976, Volume: 61, Issue:5

    Topics: Adrenergic beta-Antagonists; Aging; Alprenolol; Animals; Blood Pressure; Hypertension; Male; Metopro

1976
Effects of beta-adrenoreceptor antagonists on sino-aortic baroreflex sensitivity and blood pressure in hypertensive man.
    Clinical science (London, England : 1979), 1979, Volume: 57, Issue:3

    Topics: Acebutolol; Adolescent; Adrenergic beta-Agonists; Adult; Aging; Blood Pressure; Female; Heart Rate;

1979
Plasma metoprolol concentrations in young, old and hypertensive subjects.
    British journal of clinical pharmacology, 1977, Volume: 4, Issue:4

    Topics: Adult; Aged; Aging; Blood Urea Nitrogen; Creatinine; Female; Humans; Hypertension; Male; Metoprolol;

1977
Subsensitivity to beta-adrenoceptor agonists in pacemakers isolated from senescent rats.
    General pharmacology, 1991, Volume: 22, Issue:5

    Topics: Adrenergic beta-Agonists; Aging; Animals; Cocaine; Ethanolamines; Heart; Heart Rate; In Vitro Techni

1991
The beta-adrenergic transduction system in kidneys from young and senescent rats.
    European journal of pharmacology, 1990, Mar-13, Volume: 188, Issue:2-3

    Topics: Adenylyl Cyclase Inhibitors; Aging; Animals; Cyclic AMP; Guanylyl Imidodiphosphate; In Vitro Techniq

1990
Effect of aging on the pharmcokinetics of atenolol, metoprolol and propranolol in the rat.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 254, Issue:1

    Topics: Aging; Animals; Antipyrine; Atenolol; Male; Metabolic Clearance Rate; Metoprolol; Orosomucoid; Propr

1990
Antihypertensive treatment in elderly hypertensives: implications of the MEHP study.
    Journal of cardiovascular pharmacology, 1987, Volume: 10 Suppl 2

    Topics: Aged; Aging; Antihypertensive Agents; Blood Pressure; Humans; Hypertension; Metoprolol; Middle Aged;

1987
Beta-adrenoceptors and human skeletal muscle characterisation of receptor subtype and effect of age.
    British journal of clinical pharmacology, 1989, Volume: 27, Issue:1

    Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Aging; Binding, Competitive; Female; Humans; M

1989