metoprolol has been researched along with Ache in 13 studies
Metoprolol: A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
metoprolol : A propanolamine that is 1-(propan-2-ylamino)propan-2-ol substituted by a 4-(2-methoxyethyl)phenoxy group at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pain is often experienced when propofol is injected, and intravenous lidocaine is often effective in preventing such pain." | 9.10 | Pain on injection of propofol: comparison of metoprolol with lidocaine. ( Aşik, I; Gülay, I; Tulunay, M; Yörükoğlu, D, 2003) |
| "A total of 1395 patients aged 40 to 74 years were included in a double blind trial with the beta 1 selective blocker metoprolol in suspected acute myocardial infarction." | 9.05 | Effect of metoprolol on chest pain in acute myocardial infarction. ( Herlitz, J; Hjalmarson, A; Holmberg, S; Pennert, K; Swedberg, K; Vedin, A; Waagstein, F; Waldenström, A; Wedel, H; Wilhelmsen, L, 1984) |
| "The effect of metoprolol on chest pain was compared with that of placebo in all randomized patients." | 9.05 | Göteborg Metoprolol Trial: effects on chest pain. ( Herlitz, J; Hjalmarson, A; Holmberg, S; Richterova, A; Swedberg, K; Vedin, A; Waagstein, F; Waldenström, A; Wennerblom, B; Wilhelmsson, C, 1984) |
| "The Glycemic Effect in Diabetes Mellitus: Carvedilol-Metoprolol Comparison in Hypertensives (GEMINI) trial compared the metabolic effects of two beta-blockers in people with type 2 diabetes and hypertension treated with renin-angiotensin system (RAS) blockade and found differences in metabolic outcomes." | 5.12 | beta-blocker use and diabetes symptom score: results from the GEMINI study. ( Anderson, KM; Bakris, GL; Bell, DS; Dalal, MR; Fonseca, V; Iyengar, M; Katholi, RE; Lukas, MA; McGill, JB; Messerli, FH; Phillips, RA; Raskin, P; Wright, JT, 2007) |
| "Pain is often experienced when propofol is injected, and intravenous lidocaine is often effective in preventing such pain." | 5.10 | Pain on injection of propofol: comparison of metoprolol with lidocaine. ( Aşik, I; Gülay, I; Tulunay, M; Yörükoğlu, D, 2003) |
| "A total of 1395 patients aged 40 to 74 years were included in a double blind trial with the beta 1 selective blocker metoprolol in suspected acute myocardial infarction." | 5.05 | Effect of metoprolol on chest pain in acute myocardial infarction. ( Herlitz, J; Hjalmarson, A; Holmberg, S; Pennert, K; Swedberg, K; Vedin, A; Waagstein, F; Waldenström, A; Wedel, H; Wilhelmsen, L, 1984) |
| "The Göteborg Metoprolol Trial was a double-blind, placebo-controlled, stratified trial aimed at evaluating the effect of the beta 1-selective blocker, metoprolol, in suspected acute myocardial infarction and during 2 years of follow-up." | 5.05 | Göteborg Metoprolol Trial: design, patient characteristics and conduct. ( Herlitz, J; Holmberg, S; Pennert, K; Swedberg, K; Vedin, A; Waagstein, F; Waldenström, A; Waldenström, J; Wedel, H; Wilhelmsen, L, 1984) |
| "The effect of metoprolol on chest pain was compared with that of placebo in all randomized patients." | 5.05 | Göteborg Metoprolol Trial: effects on chest pain. ( Herlitz, J; Hjalmarson, A; Holmberg, S; Richterova, A; Swedberg, K; Vedin, A; Waagstein, F; Waldenström, A; Wennerblom, B; Wilhelmsson, C, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (46.15) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Chou, AK | 3 |
| Chen, YW | 3 |
| Cadirci, E | 1 |
| Suleyman, H | 1 |
| Hacimuftuoglu, A | 1 |
| Halici, Z | 1 |
| Akcay, F | 1 |
| Aşik, I | 1 |
| Yörükoğlu, D | 1 |
| Gülay, I | 1 |
| Tulunay, M | 1 |
| Mahajan, R | 1 |
| McGill, JB | 1 |
| Bakris, GL | 1 |
| Fonseca, V | 1 |
| Raskin, P | 1 |
| Messerli, FH | 1 |
| Phillips, RA | 1 |
| Katholi, RE | 1 |
| Wright, JT | 1 |
| Iyengar, M | 1 |
| Anderson, KM | 1 |
| Lukas, MA | 1 |
| Dalal, MR | 1 |
| Bell, DS | 1 |
| Xiao, C | 1 |
| Zhou, C | 1 |
| Atlas, G | 1 |
| Delphin, E | 1 |
| Ye, JH | 1 |
| Herlitz, J | 6 |
| Hjalmarson, A | 4 |
| Holmberg, S | 5 |
| Pennert, K | 2 |
| Swedberg, K | 6 |
| Vedin, A | 3 |
| Waagstein, F | 5 |
| Waldenström, A | 5 |
| Wedel, H | 2 |
| Wilhelmsen, L | 2 |
| Waldenström, J | 2 |
| Richterova, A | 1 |
| Wennerblom, B | 1 |
| Wilhelmsson, C | 1 |
| Risenfors, M | 1 |
| Berg, CH | 1 |
| Dellborg, M | 1 |
| Gustavsson, G | 1 |
| Gottfridsson, C | 1 |
| Lomsky, M | 1 |
| Hjalmarsson, A | 1 |
| Rydén, L | 1 |
| Mattioli, G | 1 |
| Cioni, G | 1 |
| Andreoli, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Evaluation of the Combination of Magnesium and Lidocaine for the Pretreatment of Pain That is Caused by the Injection of Propofol.[NCT01342510] | Phase 4 | 200 participants (Actual) | Interventional | 2011-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Ten seconds following injection of propofol, subjects were asked Are you having pain at your IV site? Any behavioral signs were noted. Injection pain was assessed using the following four point scale: 0 = no pain; 1 = mild pain (pain reported only in response to questioning and without behavioral signs); 2 = moderate pain (pain reported in response to questioning and accompanied by a behavioral sign, or pain reported spontaneously without questioning); and 3 = severe pain (strong vocal response or response accompanied by facial grimacing, arm withdrawal, or tears)." (NCT01342510)
Timeframe: < 1 minute.
| Intervention | participants reporting pain (Number) |
|---|---|
| Lidocaine | 11 |
| Magnesium | 25 |
| Lidocaine/Magnesium | 15 |
| Control | 18 |
Following injection of the study drug, 50 mg of propofol will be injected. Ten seconds after propofol, subjects will be asked a standard question about pain. Behavioral signs will be noted. Pain will be assessed using a four point scale: 0=no pain, 1=mild pain (pain reported only in response to questioning and without behavioral signs), 2=moderate pain (pain reported in response to questioning and a behavioral sign, or pain reported without questioning), 3=severe pain (strong vocal response or behavioral response). (NCT01342510)
Timeframe: Approximately 10 seconds following administration of propofol.
| Intervention | percentage of patients reporting pain (Number) |
|---|---|
| Lidocaine | 29 |
| Magnesium | 57 |
| Lidocaine/Magnesium | 41 |
| Control | 46 |
9 trials available for metoprolol and Ache
| Article | Year |
|---|---|
Pain on injection of propofol: comparison of metoprolol with lidocaine.
Topics: Adrenergic beta-Antagonists; Analysis of Variance; Anesthetics, Intravenous; Anesthetics, Local; Hum | 2003 |
beta-blocker use and diabetes symptom score: results from the GEMINI study.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Carbazoles; Carvedilol; Cognition; Diab | 2007 |
Effect of metoprolol on chest pain in acute myocardial infarction.
Topics: Adult; Aged; Analgesics; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Heart Rate; | 1984 |
Enzymatically and electrocardiographically estimated infarct size in relation to pain in acute myocardial infarction.
Topics: Adult; Aged; Analgesics; Clinical Trials as Topic; Electrocardiography; Humans; L-Lactate Dehydrogen | 1984 |
Göteborg Metoprolol Trial: design, patient characteristics and conduct.
Topics: Aged; Arrhythmias, Cardiac; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Electroca | 1984 |
Göteborg Metoprolol Trial: effects on chest pain.
Topics: Administration, Oral; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Injection | 1984 |
Early treatment with thrombolysis and beta-blockade in suspected acute myocardial infarction: results from the TEAHAT Study.
Topics: Aged; Drug Therapy, Combination; Electrocardiography; Female; Humans; Male; Metoprolol; Middle Aged; | 1991 |
Variability, prediction and prognostic significance of chest pain in acute myocardial infarction.
Topics: Analgesia; Clinical Trials as Topic; Humans; Metoprolol; Morphine; Myocardial Infarction; Pain; Prog | 1986 |
Time sequence of anginal pain.
Topics: Adult; Aged; Angina Pectoris; Circadian Rhythm; Female; Humans; Isosorbide Dinitrate; Male; Metoprol | 1986 |
4 other studies available for metoprolol and Ache
| Article | Year |
|---|---|
Beta-blocker carteolol and oxprenolol produce cutaneous analgesia in response to needle pinpricks in the rat.
Topics: Acebutolol; Analgesia; Anesthetics, Local; Animals; Bupivacaine; Butoxamine; Carteolol; Dose-Respons | 2023 |
Beta-blocker carteolol and oxprenolol produce cutaneous analgesia in response to needle pinpricks in the rat.
Topics: Acebutolol; Analgesia; Anesthetics, Local; Animals; Bupivacaine; Butoxamine; Carteolol; Dose-Respons | 2023 |
Beta-blocker carteolol and oxprenolol produce cutaneous analgesia in response to needle pinpricks in the rat.
Topics: Acebutolol; Analgesia; Anesthetics, Local; Animals; Bupivacaine; Butoxamine; Carteolol; Dose-Respons | 2023 |
Beta-blocker carteolol and oxprenolol produce cutaneous analgesia in response to needle pinpricks in the rat.
Topics: Acebutolol; Analgesia; Anesthetics, Local; Animals; Bupivacaine; Butoxamine; Carteolol; Dose-Respons | 2023 |
Beta-blocker carteolol and oxprenolol produce cutaneous analgesia in response to needle pinpricks in the rat.
Topics: Acebutolol; Analgesia; Anesthetics, Local; Animals; Bupivacaine; Butoxamine; Carteolol; Dose-Respons | 2023 |
Beta-blocker carteolol and oxprenolol produce cutaneous analgesia in response to needle pinpricks in the rat.
Topics: Acebutolol; Analgesia; Anesthetics, Local; Animals; Bupivacaine; Butoxamine; Carteolol; Dose-Respons | 2023 |
Beta-blocker carteolol and oxprenolol produce cutaneous analgesia in response to needle pinpricks in the rat.
Topics: Acebutolol; Analgesia; Anesthetics, Local; Animals; Bupivacaine; Butoxamine; Carteolol; Dose-Respons | 2023 |
Beta-blocker carteolol and oxprenolol produce cutaneous analgesia in response to needle pinpricks in the rat.
Topics: Acebutolol; Analgesia; Anesthetics, Local; Animals; Bupivacaine; Butoxamine; Carteolol; Dose-Respons | 2023 |
Beta-blocker carteolol and oxprenolol produce cutaneous analgesia in response to needle pinpricks in the rat.
Topics: Acebutolol; Analgesia; Anesthetics, Local; Animals; Bupivacaine; Butoxamine; Carteolol; Dose-Respons | 2023 |
Indirect role of beta2-adrenergic receptors in the mechanism of analgesic action of nonsteroidal antiinflammatory drugs.
Topics: Adrenalectomy; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Analgesics; Animals; Anti- | 2010 |
Mechanism of action of metoprolol in reducing propofol-induced pain.
Topics: Anesthetics, Intravenous; Animals; Humans; Metoprolol; Pain; Propofol; Sympatholytics | 2005 |
Labetalol facilitates GABAergic transmission to rat periaqueductal gray neurons via antagonizing beta1-adrenergic receptors--a possible mechanism underlying labetalol-induced analgesia.
Topics: Action Potentials; Adrenergic alpha-Antagonists; Adrenergic beta-1 Receptor Antagonists; Analgesics; | 2008 |