metolazone has been researched along with Nephrotic Syndrome in 8 studies
Metolazone: A quinazoline-sulfonamide derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS.
metolazone : A quinazoline that consists of 1,2,3,4-tetrahydroquinazolin-4-one bearing additional methyl, 2-tolyl, sulfamyl and chloro substituents at positions 2, 3, 6 and 7 respectively. A quinazoline diuretic, with properties similar to thiazide diuretics.
Nephrotic Syndrome: A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in the urine results in complications such as HYPOPROTEINEMIA; generalized EDEMA; HYPERTENSION; and HYPERLIPIDEMIAS. Diseases associated with nephrotic syndrome generally cause chronic kidney dysfunction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Eighteen patients with hepatic cirrhosis or nephrotic syndrome and having edema and/or ascites were treated during successive periods with metolazone 5 to 40 mg/day, spironolactone 100 mg/day, and with both diuretics concurrently." | 9.04 | Metolazone and spironolactone in cirrhosis and the nephrotic syndrome. ( Arruda, JA; Dhupelia, VB; Kane, RE; Lang, GR; Nascimento, L; Westenfelder, C, 1977) |
| "The effects of the new diuretic metolazone were studied in ten patients with chronic renal insufficiency and ten with nephrotic syndrome." | 7.65 | Long-term diuretic therapy with metolazone of renal failure and the nephrotic syndrome. ( Kane, RE; Paton, RR, 1977) |
| "The metolazone-furosemide combination of diuretics was compared with the thiazide-furosemide combination in nephrotic patients with edema." | 5.06 | A comparison of combinations of diuretics in nephrotic edema. ( Garin, EH, 1987) |
| "Eighteen patients with hepatic cirrhosis or nephrotic syndrome and having edema and/or ascites were treated during successive periods with metolazone 5 to 40 mg/day, spironolactone 100 mg/day, and with both diuretics concurrently." | 5.04 | Metolazone and spironolactone in cirrhosis and the nephrotic syndrome. ( Arruda, JA; Dhupelia, VB; Kane, RE; Lang, GR; Nascimento, L; Westenfelder, C, 1977) |
| "The effects of the new diuretic metolazone were studied in ten patients with chronic renal insufficiency and ten with nephrotic syndrome." | 3.65 | Long-term diuretic therapy with metolazone of renal failure and the nephrotic syndrome. ( Kane, RE; Paton, RR, 1977) |
| "Renal recovery is much better when acute renal failure is caused by nephrotic syndrome." | 1.30 | [Severe nephrotic syndrome with reversible acute kidney failure in lupus-associated membranous nephropathy]. ( Kuhlmann, U; Mettang, T; Pauli-Magnus, C, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (62.50) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hoyer, RJ | 1 |
| Leung, N | 1 |
| Witzig, TE | 1 |
| Lacy, MQ | 1 |
| Barzilay, Z | 1 |
| Paret, G | 1 |
| Pauli-Magnus, C | 1 |
| Mettang, T | 1 |
| Kuhlmann, U | 1 |
| Lang, GR | 1 |
| Westenfelder, C | 1 |
| Nascimento, L | 1 |
| Dhupelia, VB | 1 |
| Arruda, JA | 1 |
| Kane, RE | 2 |
| Kshirsagar, NA | 2 |
| Shah, BP | 2 |
| Paul, T | 2 |
| Acharya, VN | 2 |
| Sattur, PB | 1 |
| Sheth, UK | 2 |
| Gupta, KC | 1 |
| Vora, KK | 1 |
| Sanghvi, B | 1 |
| Mehta, JM | 1 |
| Paton, RR | 1 |
| Garin, EH | 1 |
2 trials available for metolazone and Nephrotic Syndrome
| Article | Year |
|---|---|
Metolazone and spironolactone in cirrhosis and the nephrotic syndrome.
Topics: Adult; Aged; Blood Cell Count; Blood Glucose; Blood Pressure; Body Weight; Chlorides; Clinical Trial | 1977 |
A comparison of combinations of diuretics in nephrotic edema.
Topics: Administration, Oral; Adolescent; Benzothiadiazines; Child; Child, Preschool; Clinical Trials as Top | 1987 |
6 other studies available for metolazone and Nephrotic Syndrome
| Article | Year |
|---|---|
Treatment of diuretic refractory pleural effusions with bevacizumab in four patients with primary systemic amyloidosis.
Topics: Amyloidosis; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bevacizumab; Captopril; Ches | 2007 |
The nephrotic syndrome.
Topics: Child; Diuretics; Drug Therapy, Combination; Furosemide; Humans; Infant; Metolazone; Nephrotic Syndr | 1998 |
[Severe nephrotic syndrome with reversible acute kidney failure in lupus-associated membranous nephropathy].
Topics: Acute Kidney Injury; Adult; Antibodies, Anticardiolipin; Antibodies, Antinuclear; Anticoagulants; An | 1999 |
Effect of nonsteroidal anti-inflammatory agents and diuretics in nephrotic syndrome patients.
Topics: Anti-Inflammatory Agents; Diuretics; Drug Interactions; Drug Therapy, Combination; Furosemide; Glome | 1979 |
Effect of metolazone addition on furosemide resistant cases of edema.
Topics: Adolescent; Adult; Diuretics; Drug Resistance; Drug Therapy, Combination; Edema; Female; Furosemide; | 1978 |
Long-term diuretic therapy with metolazone of renal failure and the nephrotic syndrome.
Topics: Adult; Aged; Antihypertensive Agents; Blood Glucose; Blood Pressure; Body Weight; Creatinine; Diuret | 1977 |