metolazone has been researched along with Kidney Failure, Chronic in 10 studies
Metolazone: A quinazoline-sulfonamide derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS.
metolazone : A quinazoline that consists of 1,2,3,4-tetrahydroquinazolin-4-one bearing additional methyl, 2-tolyl, sulfamyl and chloro substituents at positions 2, 3, 6 and 7 respectively. A quinazoline diuretic, with properties similar to thiazide diuretics.
Kidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "4 mg/kg/d) and furosemide (2 to 4 mg/kg/d) in achieving a natriuresis and diuresis was measured in 14 children during 22 episodes of edema resistant to furosemide alone." | 7.67 | Efficacy of metolazone and furosemide in children with furosemide-resistant edema. ( Arnold, WC, 1984) |
| "The effects of the new diuretic metolazone were studied in ten patients with chronic renal insufficiency and ten with nephrotic syndrome." | 7.65 | Long-term diuretic therapy with metolazone of renal failure and the nephrotic syndrome. ( Kane, RE; Paton, RR, 1977) |
| "4 mg/kg/d) and furosemide (2 to 4 mg/kg/d) in achieving a natriuresis and diuresis was measured in 14 children during 22 episodes of edema resistant to furosemide alone." | 3.67 | Efficacy of metolazone and furosemide in children with furosemide-resistant edema. ( Arnold, WC, 1984) |
| "The effects of the new diuretic metolazone were studied in ten patients with chronic renal insufficiency and ten with nephrotic syndrome." | 3.65 | Long-term diuretic therapy with metolazone of renal failure and the nephrotic syndrome. ( Kane, RE; Paton, RR, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (70.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Au, HY | 2 |
| Chan, KY | 2 |
| Yap, DYH | 1 |
| Yip, T | 2 |
| Wong, CY | 1 |
| Cheng, HW | 1 |
| Sham, MK | 1 |
| Li, CW | 1 |
| Groth, H | 2 |
| Vetter, H | 2 |
| Kuhlmann, U | 2 |
| Burger, R | 1 |
| Siegenthaler, W | 2 |
| Vetter, W | 2 |
| Arnold, WC | 1 |
| Farthing, D | 1 |
| Sica, DA | 1 |
| Fakhry, I | 1 |
| Gehr, TW | 1 |
| Bennett, WM | 1 |
| McDonald, WJ | 1 |
| Kuehnel, E | 1 |
| Hartnett, MN | 1 |
| Porter, GA | 1 |
| Kshirsagar, NA | 1 |
| Gupta, KC | 1 |
| Paul, T | 1 |
| Shah, BP | 1 |
| Vora, KK | 1 |
| Sanghvi, B | 1 |
| Acharya, VN | 1 |
| Mehta, JM | 1 |
| Sheth, UK | 1 |
| Paton, RR | 1 |
| Kane, RE | 1 |
| Achermann, R | 1 |
3 trials available for metolazone and Kidney Failure, Chronic
| Article | Year |
|---|---|
[Antihypertensive therapy in chronic kidney failure. Comparison of pharmacologic effect of metolazone and furosemide].
Topics: Adult; Aged; Clinical Trials as Topic; Diuretics; Double-Blind Method; Female; Furosemide; Humans; H | 1983 |
Do diuretics have antihypertensive properties independent of natriuresis?
Topics: Adult; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Diuretics; Double-Blind Me | 1977 |
[Diuretics and antihypertensive agents in chronic kidney insufficiency: comparison of the effects of metolazone and furosemide].
Topics: Adult; Aged; Diuretics; Drug Therapy, Combination; Female; Furosemide; Humans; Hydralazine; Hyperten | 1985 |
7 other studies available for metolazone and Kidney Failure, Chronic
| Article | Year |
|---|---|
Topics: Conservative Treatment; Furosemide; Heart Failure; Humans; Kidney Failure, Chronic; Metolazone | 2023 |
Combination therapy with low-dose metolazone and furosemide: a "needleless" approach in managing refractory fluid overload in elderly renal failure patients under palliative care.
Topics: Aged; Aged, 80 and over; Diuretics; Drug Therapy, Combination; Edema; Furosemide; Humans; Kidney Fai | 2014 |
Efficacy of metolazone and furosemide in children with furosemide-resistant edema.
Topics: Adolescent; Child; Child, Preschool; Diuresis; Diuretics; Drug Evaluation; Drug Resistance; Drug Syn | 1984 |
Novel high-performance liquid chromatographic method using solid-phase on-line elution for determination of metolazone in plasma and whole blood.
Topics: Chromatography, High Pressure Liquid; Humans; Kidney Failure, Chronic; Male; Metolazone; Reproducibi | 1994 |
Diulo.
Topics: Costs and Cost Analysis; Diuretics; Humans; Hypertension; Kidney Failure, Chronic; Metolazone | 1979 |
Effect of metolazone addition on furosemide resistant cases of edema.
Topics: Adolescent; Adult; Diuretics; Drug Resistance; Drug Therapy, Combination; Edema; Female; Furosemide; | 1978 |
Long-term diuretic therapy with metolazone of renal failure and the nephrotic syndrome.
Topics: Adult; Aged; Antihypertensive Agents; Blood Glucose; Blood Pressure; Body Weight; Creatinine; Diuret | 1977 |