metolazone has been researched along with Hypokalemia in 4 studies
Metolazone: A quinazoline-sulfonamide derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS.
metolazone : A quinazoline that consists of 1,2,3,4-tetrahydroquinazolin-4-one bearing additional methyl, 2-tolyl, sulfamyl and chloro substituents at positions 2, 3, 6 and 7 respectively. A quinazoline diuretic, with properties similar to thiazide diuretics.
Hypokalemia: Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. It may be manifested clinically by neuromuscular disorders ranging from weakness to paralysis, by electrocardiographic abnormalities (depression of the T wave and elevation of the U wave), by renal disease, and by gastrointestinal disorders. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gitelman's syndrome is an autosomal recessive renal tubular disorder characterized by hypokalemic metabolic alkalosis, hypomagnesemia, and hypocalciuria." | 1.31 | Functional expression of mutations in the human NaCl cotransporter: evidence for impaired routing mechanisms in Gitelman's syndrome. ( Bindels, RJ; De Jong, JC; Knoers, NV; Van Den Heuvel, LP; Van Der Vliet, WA; Willems, PH, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sabath, E | 1 |
| Meade, P | 1 |
| Berkman, J | 1 |
| de los Heros, P | 1 |
| Moreno, E | 1 |
| Bobadilla, NA | 1 |
| Vázquez, N | 1 |
| Ellison, DH | 1 |
| Gamba, G | 1 |
| De Jong, JC | 1 |
| Van Der Vliet, WA | 1 |
| Van Den Heuvel, LP | 1 |
| Willems, PH | 1 |
| Knoers, NV | 1 |
| Bindels, RJ | 1 |
| Greenberg, A | 1 |
4 other studies available for metolazone and Hypokalemia
| Article | Year |
|---|---|
Pathophysiology of functional mutations of the thiazide-sensitive Na-Cl cotransporter in Gitelman disease.
Topics: Alkalosis; Animals; Carrier Proteins; Diuretics; Dose-Response Relationship, Drug; Female; Humans; H | 2004 |
Functional expression of mutations in the human NaCl cotransporter: evidence for impaired routing mechanisms in Gitelman's syndrome.
Topics: Alkalosis; Animals; Calcium; Carrier Proteins; Female; Glycosylation; Humans; Hypokalemia; Immunohis | 2002 |
Microx.
Topics: Diuretics; Humans; Hypertension; Hypokalemia; Metolazone | 1988 |
What's new in diuretic therapy.
Topics: Acetazolamide; Acid-Base Imbalance; Biological Transport; Diuretics; Drug Resistance; Ethacrynic Aci | 1986 |