metolazone has been researched along with Hypertension in 35 studies
Metolazone: A quinazoline-sulfonamide derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS.
metolazone : A quinazoline that consists of 1,2,3,4-tetrahydroquinazolin-4-one bearing additional methyl, 2-tolyl, sulfamyl and chloro substituents at positions 2, 3, 6 and 7 respectively. A quinazoline diuretic, with properties similar to thiazide diuretics.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study compared the incidence of cough with the angiotensin-converting enzyme (ACE) inhibitor lisinopril and the diuretic metolazone with angiotensin II receptor antagonist losartan in elderly hypertensive patients with previous histories of ACE inhibitor-induced cough." | 9.08 | Double-blind comparison of losartan, lisinopril, and metolazone in elderly hypertensive patients with previous angiotensin-converting enzyme inhibitor-induced cough. ( Chan, P; Huang, TY; Ko, JT; Lee, YS; Lin, TS; Tomlinson, B, 1997) |
| "Two multicenter, double-blind, randomized studies were performed to determine the antihypertensive efficacy and effects on laboratory values of a new, shorter-acting formulation of metolazone in patients with mild to moderate hypertension." | 9.06 | Clinical studies of a new, low-dose formulation of metolazone for the treatment of hypertension. ( Curry, CL; Harris, R; Janda, SM; MacKay, JH; Nugent, CA; Ryan, J; Schnaper, H; Schoenberger, J, 1986) |
| " A cross-over study was done in twenty patients with hypertension to compare the effects of chlorothiazide (0-5 g twice daily) and metolazone (5 mg daily) in combination with other anti-hypertensive agents." | 9.04 | A comparison of the effects of chlorothiazide and of metolazone in the treatment of hypertension. ( Hua, AS; Kincaid-Smith, P, 1976) |
| "Metolazone-induced acute pancreatitis and hypercalcemia are described in a 58-year-old woman with severe congestive cardiac failure." | 7.68 | Case report: metolazone-associated hypercalcemia and acute pancreatitis. ( Anderson, PE; Austin, SM; Ellis, GG, 1991) |
| "To evaluate the role of the renin-angiotensin system and sodium depletion in the hypotensive response to 1-sarcosine-8-alanine-angiotensin II (saralasin), 15 male patients with essential hypertension were studied on a diet containing 120 mEq of sodium and 100 mEq of potassium per day." | 7.66 | Angiotensin II, plasma renin and sodium depletion as determinants of blood pressure response to saralasin in essential hypertension. ( Barrett, JD; Eggena, P; Golub, MS; Sambhi, MP; Thananopavarn, C, 1980) |
| "This study compared the incidence of cough with the angiotensin-converting enzyme (ACE) inhibitor lisinopril and the diuretic metolazone with angiotensin II receptor antagonist losartan in elderly hypertensive patients with previous histories of ACE inhibitor-induced cough." | 5.08 | Double-blind comparison of losartan, lisinopril, and metolazone in elderly hypertensive patients with previous angiotensin-converting enzyme inhibitor-induced cough. ( Chan, P; Huang, TY; Ko, JT; Lee, YS; Lin, TS; Tomlinson, B, 1997) |
| "Two multicenter, double-blind, randomized studies were performed to determine the antihypertensive efficacy and effects on laboratory values of a new, shorter-acting formulation of metolazone in patients with mild to moderate hypertension." | 5.06 | Clinical studies of a new, low-dose formulation of metolazone for the treatment of hypertension. ( Curry, CL; Harris, R; Janda, SM; MacKay, JH; Nugent, CA; Ryan, J; Schnaper, H; Schoenberger, J, 1986) |
| " A cross-over study was done in twenty patients with hypertension to compare the effects of chlorothiazide (0-5 g twice daily) and metolazone (5 mg daily) in combination with other anti-hypertensive agents." | 5.04 | A comparison of the effects of chlorothiazide and of metolazone in the treatment of hypertension. ( Hua, AS; Kincaid-Smith, P, 1976) |
| "Metolazone-induced acute pancreatitis and hypercalcemia are described in a 58-year-old woman with severe congestive cardiac failure." | 3.68 | Case report: metolazone-associated hypercalcemia and acute pancreatitis. ( Anderson, PE; Austin, SM; Ellis, GG, 1991) |
| "To evaluate the role of the renin-angiotensin system and sodium depletion in the hypotensive response to 1-sarcosine-8-alanine-angiotensin II (saralasin), 15 male patients with essential hypertension were studied on a diet containing 120 mEq of sodium and 100 mEq of potassium per day." | 3.66 | Angiotensin II, plasma renin and sodium depletion as determinants of blood pressure response to saralasin in essential hypertension. ( Barrett, JD; Eggena, P; Golub, MS; Sambhi, MP; Thananopavarn, C, 1980) |
| "In two patients with severe hypertension and moderately severe renal insufficiency, metolazone and furosemide were used in combination with propranolol, methyldopa, and hydralazine to augment control of blood pressure." | 3.66 | Severe electrolyte disturbances associated with metolazone and furosemide. ( Black, WD; Roman, J; Shiner, PT, 1978) |
| ") were followed monthly in patients with essential hypertension on metolazone, 5 mg daily for three months and with added propranolol, 40 to 160 mg, for the subsequent three months." | 3.65 | Antihypertensive and renin angiotensin effects of metolazone with and without propranolol. ( Barrett, JD; Eggena, P; Sambhi, MP; Thananopavarn, C; Tuck, M; Wiedman, C, 1977) |
| " The side-effect score for edema was lower with ISR plus diuretics than with other combinations, whereas the ACE inhibitor was associated with a higher score for cough." | 2.67 | Efficacy and safety of various combination therapies based on a calcium antagonist in essential hypertension: results of a placebo-controlled randomized trial. ( Lüscher, TF; Waeber, B, 1993) |
| "5 mg/day of metolazone or 25 mg/day of chlorthalidone are effective antihypertensive agents but that blood pressure lowering may be inconsistent at these dosage levels." | 2.66 | Low-dose diuretic therapy for hypertension. ( Moser, M, 1986) |
| " Plasma renin concentration and the aortic renin content of the spontaneously hypertensive rat showed divergent changes in response to a blood pressure fall associated with acute diuretic therapy, chronic administration of hydrallazine and in some animals in response to chronic administration of propranolol." | 1.26 | Partial characterization of aortic renin in the spontaneously hypertensive rat and its interrelationship with plasma renin, blood pressure and sodium balance. ( Barrett, JD; Eggena, P; Sambhi, MP, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (85.71) | 18.7374 |
| 1990's | 4 (11.43) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (2.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kasai, T | 1 |
| Bradley, TD | 1 |
| Friedman, O | 1 |
| Logan, AG | 1 |
| Groth, H | 1 |
| Vetter, H | 1 |
| Kuhlmann, U | 1 |
| Burger, R | 1 |
| Siegenthaler, W | 1 |
| Vetter, W | 1 |
| Thananopavarn, C | 2 |
| Golub, MS | 1 |
| Eggena, P | 3 |
| Barrett, JD | 3 |
| Sambhi, MP | 3 |
| Hickey, N | 1 |
| O'Donoghue, S | 1 |
| Guiry, U | 1 |
| Graham, I | 1 |
| Mulcahy, R | 1 |
| Belton, P | 1 |
| Carmody, M | 1 |
| Sheridan, J | 1 |
| Quigley, P | 1 |
| Jackson, M | 1 |
| Winchester, JF | 1 |
| Kellett, RJ | 1 |
| Boddy, K | 1 |
| Boyle, P | 1 |
| Dargie, HJ | 1 |
| Mahaffey, ME | 1 |
| Ward, DM | 1 |
| Kennedy, AC | 1 |
| Lüscher, TF | 1 |
| Waeber, B | 1 |
| Chan, P | 1 |
| Tomlinson, B | 1 |
| Huang, TY | 1 |
| Ko, JT | 1 |
| Lin, TS | 1 |
| Lee, YS | 1 |
| Ward, W | 1 |
| Abetel, G | 1 |
| Allenbach, C | 1 |
| Chapuis, P | 1 |
| Christeler, P | 1 |
| Delacrétaz, B | 1 |
| Karly, M | 1 |
| Magnenat, G | 1 |
| Morandi, D | 1 |
| Muhlbauer, MA | 1 |
| de Senarciens, B | 1 |
| Terrier, P | 1 |
| Troillet, F | 1 |
| Suh, K | 1 |
| Sood, R | 1 |
| Hoyt, JL | 1 |
| Rhomberg, F | 1 |
| Bächtold, H | 1 |
| Danczkay, I | 1 |
| Dubi, A | 1 |
| Fetscherin, R | 1 |
| Kälin, R | 1 |
| Knuchel, HR | 1 |
| Lauper, N | 1 |
| Mannhart, M | 1 |
| Müller, T | 1 |
| Pugatsch, I | 1 |
| Renggli, I | 1 |
| Schäublin, A | 1 |
| Spillmann, B | 1 |
| Veraguth, F | 1 |
| Walther, P | 1 |
| Black, WD | 1 |
| Shiner, PT | 1 |
| Roman, J | 1 |
| Dornfeld, L | 1 |
| Kane, RE | 1 |
| Van Hoose, MC | 1 |
| Cutler, RE | 1 |
| Weingarten, C | 1 |
| Cangiano, JL | 1 |
| Benedetto, ER | 1 |
| Tuck, M | 1 |
| Wiedman, C | 1 |
| Thompson, DM | 1 |
| Nichols, TO | 1 |
| Kessler, FO | 1 |
| Hua, AS | 1 |
| Kincaid-Smith, P | 1 |
| Anderson, PE | 1 |
| Ellis, GG | 1 |
| Austin, SM | 1 |
| Beaumont, K | 1 |
| Vaughn, DA | 1 |
| Casto, R | 1 |
| Printz, MP | 1 |
| Fanestil, DD | 1 |
| Reams, GP | 1 |
| Bauer, JH | 1 |
| Basso, B | 1 |
| Gac, JC | 1 |
| Rebolledo, H | 1 |
| Román, O | 1 |
| Valenzuela, MA | 1 |
| Cespedes, E | 1 |
| Curry, CL | 1 |
| Janda, SM | 1 |
| Harris, R | 1 |
| MacKay, JH | 1 |
| Nugent, CA | 1 |
| Ryan, J | 1 |
| Schnaper, H | 1 |
| Schoenberger, J | 1 |
| Moser, M | 1 |
| Miller, SA | 1 |
| Cobb, SD | 1 |
| Petrulis, AS | 1 |
| Vertes, V | 1 |
| Rowe, PA | 1 |
| Mather, HG | 1 |
14 trials available for metolazone and Hypertension
| Article | Year |
|---|---|
[Antihypertensive therapy in chronic kidney failure. Comparison of pharmacologic effect of metolazone and furosemide].
Topics: Adult; Aged; Clinical Trials as Topic; Diuretics; Double-Blind Method; Female; Furosemide; Humans; H | 1983 |
Metolazone and pindolol in the treatment of hypertension: a double blind multicentre trial.
Topics: Aged; Clinical Trials as Topic; Diuretics; Double-Blind Method; Female; Humans; Hypertension; Male; | 1982 |
Metolazone and bendroflumethiazide in hypertension: physiologic and metabolic observations.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Bendroflumethiazide; Blood Pressure; Diuretics; Fe | 1980 |
Efficacy and safety of various combination therapies based on a calcium antagonist in essential hypertension: results of a placebo-controlled randomized trial.
Topics: Adrenergic beta-Antagonists; Aged; Calcium Channel Blockers; Double-Blind Method; Drug Therapy, Comb | 1993 |
Double-blind comparison of losartan, lisinopril, and metolazone in elderly hypertensive patients with previous angiotensin-converting enzyme inhibitor-induced cough.
Topics: Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzothi | 1997 |
[Metolazone in arterial hypertension. Multi-centric study with 2.5 mg of Zaroxolyne (metolazone) taken in a single daily dose].
Topics: Adult; Aged; Antihypertensive Agents; Clinical Trials as Topic; Diuretics; Drug Evaluation; Drug Tol | 1978 |
[Treatment of hypertension with metolazone in general practice - a joint study (author's transl)].
Topics: Adult; Aged; Diuretics; Drug Evaluation; Female; Humans; Hypertension; Male; Metolazone; Middle Aged | 1979 |
Metolazone in essential hypertension: the long-term clinical efficacy of a new diuretic.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Diuretics; Female; Heart Rate; Humans; Hypert | 1975 |
Antihypertensive efficacy of metolazone (Zaroxolyn) alone and combined with reserpine in treatment of essential hypertension.
Topics: Adult; Aged; Blood Glucose; Blood Pressure; Body Weight; Clinical Trials as Topic; Diuretics; Drug T | 1976 |
A comparison of the effects of chlorothiazide and of metolazone in the treatment of hypertension.
Topics: Adult; Aged; Chlorothiazide; Diuretics; Female; Humans; Hypertension; Male; Metolazone; Middle Aged; | 1976 |
[Metolazone, a new diuretic in essential arterial hypertension].
Topics: Adult; Aged; Blood Glucose; Blood Pressure; Clinical Trials as Topic; Diuretics; Female; Heart Rate; | 1986 |
Clinical studies of a new, low-dose formulation of metolazone for the treatment of hypertension.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Diuretics; Double-Blind Method; Female; Human | 1986 |
Low-dose diuretic therapy for hypertension.
Topics: Chlorthalidone; Diuretics; Dose-Response Relationship, Drug; Double-Blind Method; Electrolytes; Fema | 1986 |
Step 1 1/2 therapy for the treatment of hypertension.
Topics: Antihypertensive Agents; Clinical Trials as Topic; Diuretics; Drug Combinations; Female; Humans; Hyd | 1985 |
21 other studies available for metolazone and Hypertension
| Article | Year |
|---|---|
Effect of intensified diuretic therapy on overnight rostral fluid shift and obstructive sleep apnoea in patients with uncontrolled hypertension.
Topics: Aged; Blood Pressure; Diuretics; Drug Resistance; Drug Therapy, Combination; Extracellular Fluid; Fe | 2014 |
Angiotensin II, plasma renin and sodium depletion as determinants of blood pressure response to saralasin in essential hypertension.
Topics: Adult; Aged; Angiotensin II; Blood Pressure; Dose-Response Relationship, Drug; Drug Therapy, Combina | 1980 |
Metolazone therapy of patients with mild to moderate hypertension.
Topics: Adult; Aged; Diuretics; Female; Humans; Hypertension; Male; Metolazone; Middle Aged | 1977 |
Hypoplastic anemia associated with metolazone.
Topics: Aged; Anemia, Aplastic; Diuretics; Female; Humans; Hypertension; Metolazone | 1979 |
Diulo.
Topics: Costs and Cost Analysis; Diuretics; Humans; Hypertension; Kidney Failure, Chronic; Metolazone | 1979 |
Metolazone for effective blood pressure reduction and diuresis.
Topics: Adult; Aged; Diuretics; Edema; Female; Humans; Hypertension; Male; Metolazone; Middle Aged | 1979 |
Severe electrolyte disturbances associated with metolazone and furosemide.
Topics: Adult; Aged; Diuretics; Drug Therapy, Combination; Female; Furosemide; Heart Failure; Humans; Hypert | 1978 |
Partial characterization of aortic renin in the spontaneously hypertensive rat and its interrelationship with plasma renin, blood pressure and sodium balance.
Topics: Angiotensin I; Animals; Aorta; Blood Pressure; Female; Hydralazine; Hypertension; Male; Metolazone; | 1978 |
Metolazone for hypertension?
Topics: Diuretics; Humans; Hypertension; Metolazone | 1978 |
Clinical evaluation of metolazone, a long-acting antihypertensive/diuretic.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Diuretics; Drug Evaluation; Drug Therapy, Comb | 1976 |
Effects of prolonged administration of metolazone in the treatment of essential hypertension.
Topics: Administration, Oral; Adult; Antihypertensive Agents; Blood Pressure; Cholesterol; Depression, Chemi | 1976 |
Use of metolazone in the treatment of refractory hypertension.
Topics: Adult; Aged; Diuretics; Female; Humans; Hypertension; Male; Metolazone; Middle Aged | 1977 |
Antihypertensive and renin angiotensin effects of metolazone with and without propranolol.
Topics: Angiotensin II; Antihypertensive Agents; Blood Pressure; Diuretics; Drug Interactions; Drug Therapy, | 1977 |
A new antihypertensive: metolazone treatment of hypertension.
Topics: Aged; Diuretics; Female; Humans; Hypertension; Male; Metolazone; Middle Aged | 1977 |
Initial experience with metolazone. Well tolerated new antihypertensive agent.
Topics: Adult; Aged; Diuretics; Dose-Response Relationship, Drug; Drug Tolerance; Female; Humans; Hypertensi | 1977 |
Effective blood pressure reduction and diuresis with metolazone.
Topics: Adult; Aged; Diuretics; Female; Humans; Hypertension; Male; Metolazone; Middle Aged | 1976 |
Case report: metolazone-associated hypercalcemia and acute pancreatitis.
Topics: Acute Disease; Female; Heart Failure; Humans; Hypercalcemia; Hypertension; Metolazone; Middle Aged; | 1991 |
Thiazide diuretic receptors in spontaneously hypertensive rats and 2-kidney 1-clip hypertensive rats.
Topics: Animals; Carrier Proteins; Female; Hypertension; Hypertension, Renovascular; Kidney; Male; Metolazon | 1990 |
The effect of triple drug therapy on renal function in patients with essential hypertension.
Topics: Adrenergic beta-Antagonists; Aged; Aldosterone; Antihypertensive Agents; Atenolol; Betaxolol; Blood | 1989 |
Microx.
Topics: Diuretics; Humans; Hypertension; Hypokalemia; Metolazone | 1988 |
Hyperosmolar non-ketotic diabetes mellitus associated with metolazone.
Topics: Diabetic Coma; Diuretics; Female; Humans; Hyperglycemic Hyperosmolar Nonketotic Coma; Hypertension; | 1985 |