metolazone and Edema
metolazone has been researched along with Edema in 18 studies
Metolazone: A quinazoline-sulfonamide derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS.
metolazone : A quinazoline that consists of 1,2,3,4-tetrahydroquinazolin-4-one bearing additional methyl, 2-tolyl, sulfamyl and chloro substituents at positions 2, 3, 6 and 7 respectively. A quinazoline diuretic, with properties similar to thiazide diuretics.
Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "2 mg/kg/day) and furosemide (4 mg/kg/day) was used in the treatment of a 2-week-old neonate who developed severe edema after cardiac surgery." | 7.68 | Combination of metolazone and furosemide in the treatment of edema in the first month of life. ( Cachero, SD; Feld, LG; Lofland, G; Springate, JE, 1990) |
| "4 mg/kg/d) and furosemide (2 to 4 mg/kg/d) in achieving a natriuresis and diuresis was measured in 14 children during 22 episodes of edema resistant to furosemide alone." | 7.67 | Efficacy of metolazone and furosemide in children with furosemide-resistant edema. ( Arnold, WC, 1984) |
| "The metolazone-furosemide combination of diuretics was compared with the thiazide-furosemide combination in nephrotic patients with edema." | 5.06 | A comparison of combinations of diuretics in nephrotic edema. ( Garin, EH, 1987) |
| "2 mg/kg/day) and furosemide (4 mg/kg/day) was used in the treatment of a 2-week-old neonate who developed severe edema after cardiac surgery." | 3.68 | Combination of metolazone and furosemide in the treatment of edema in the first month of life. ( Cachero, SD; Feld, LG; Lofland, G; Springate, JE, 1990) |
| "4 mg/kg/d) and furosemide (2 to 4 mg/kg/d) in achieving a natriuresis and diuresis was measured in 14 children during 22 episodes of edema resistant to furosemide alone." | 3.67 | Efficacy of metolazone and furosemide in children with furosemide-resistant edema. ( Arnold, WC, 1984) |
| "Renal recovery is much better when acute renal failure is caused by nephrotic syndrome." | 1.30 | [Severe nephrotic syndrome with reversible acute kidney failure in lupus-associated membranous nephropathy]. ( Kuhlmann, U; Mettang, T; Pauli-Magnus, C, 1999) |
Research
Studies (18)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (66.67) | 18.7374 |
| 1990's | 3 (16.67) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 2 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Thajudeen, B | 1 |
| Rubin, MF | 1 |
| Cheng, HW | 1 |
| Sham, MK | 1 |
| Chan, KY | 1 |
| Li, CW | 1 |
| Au, HY | 1 |
| Yip, T | 1 |
| Hoyer, RJ | 1 |
| Leung, N | 1 |
| Witzig, TE | 1 |
| Lacy, MQ | 1 |
| Arosio, E | 1 |
| Pancera, P | 1 |
| Apolloni, E | 1 |
| Covi, G | 1 |
| Lechi, A | 1 |
| Arnold, WC | 1 |
| Ghose, RR | 1 |
| Gupta, SK | 1 |
| Bamford, JM | 1 |
| Pauli-Magnus, C | 1 |
| Mettang, T | 1 |
| Kuhlmann, U | 1 |
| Truniger, B | 1 |
| Hoyt, JL | 1 |
| Sheth, UK | 2 |
| Mehta, JM | 2 |
| Paul, T | 2 |
| Nair, S | 1 |
| Sanghvi, B | 2 |
| Kshirsagar, NA | 1 |
| Gupta, KC | 1 |
| Shah, BP | 1 |
| Vora, KK | 1 |
| Acharya, VN | 1 |
| Stern, A | 1 |
| Cachero, SD | 1 |
| Lofland, G | 1 |
| Springate, JE | 1 |
| Feld, LG | 1 |
| Garin, EH | 2 |
| Jacobson, S | 1 |
| Berglund, J | 1 |
| Lins, LE | 1 |
| Richard, GA | 1 |
Trials
2 trials available for metolazone and Edema
| Article | Year |
|---|---|
A comparison of combinations of diuretics in nephrotic edema.
Topics: Administration, Oral; Adolescent; Benzothiadiazines; Child; Child, Preschool; Clinical Trials as Top | 1987 |
New diuretics - bumetanide and metolazone.
Topics: Bumetanide; Clinical Trials as Topic; Diuretics; Edema; Humans; Metolazone | 1974 |
Other Studies
16 other studies available for metolazone and Edema
| Article | Year |
|---|---|
Hemodynamic acute kidney injury in immunoglobulin A nephropathy: nephrosarca theory revisited.
Topics: Acute Kidney Injury; Diuretics; Drug Therapy, Combination; Edema; Furosemide; Glomerulonephritis, IG | 2013 |
Combination therapy with low-dose metolazone and furosemide: a "needleless" approach in managing refractory fluid overload in elderly renal failure patients under palliative care.
Topics: Aged; Aged, 80 and over; Diuretics; Drug Therapy, Combination; Edema; Furosemide; Humans; Kidney Fai | 2014 |
Treatment of diuretic refractory pleural effusions with bevacizumab in four patients with primary systemic amyloidosis.
Topics: Amyloidosis; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bevacizumab; Captopril; Ches | 2007 |
[Clinical evaluation of metolazone in edematogenic syndromes].
Topics: Adult; Aged; Coronary Disease; Diuretics; Edema; Female; Heart Failure; Heart Valve Diseases; Humans | 1984 |
Efficacy of metolazone and furosemide in children with furosemide-resistant edema.
Topics: Adolescent; Child; Child, Preschool; Diuresis; Diuretics; Drug Evaluation; Drug Resistance; Drug Syn | 1984 |
Synergistic action of metolazone with "loop" diuretics.
Topics: Aged; Diuretics; Drug Synergism; Edema; Humans; Male; Metolazone; Middle Aged; Potassium; Sodium | 1981 |
Synergistic action of metolazone with "loop" diuretics.
Topics: Diuretics; Edema; Humans; Male; Metolazone; Middle Aged | 1981 |
[Severe nephrotic syndrome with reversible acute kidney failure in lupus-associated membranous nephropathy].
Topics: Acute Kidney Injury; Adult; Antibodies, Anticardiolipin; Antibodies, Antinuclear; Anticoagulants; An | 1999 |
[Therapy edema: secondary effect without effect!].
Topics: Adult; Anuria; Diuretics; Edema; Female; Furosemide; Humans; Lymphedema; Metolazone; Obesity | 1999 |
Metolazone for effective blood pressure reduction and diuresis.
Topics: Adult; Aged; Diuretics; Edema; Female; Humans; Hypertension; Male; Metolazone; Middle Aged | 1979 |
Clinical experience with metolazone--a new diuretic--in cases of edema and ascites due to hepatic cirrhosis, C.C.F., and malnutrition.
Topics: Adult; Diuretics; Edema; Heart Failure; Humans; Liver Cirrhosis; Male; Metolazone; Nutrition Disorde | 1977 |
Effect of metolazone addition on furosemide resistant cases of edema.
Topics: Adolescent; Adult; Diuretics; Drug Resistance; Drug Therapy, Combination; Edema; Female; Furosemide; | 1978 |
Metolazone, a diuretic agent.
Topics: Ascites; Diuresis; Diuretics; Edema; Humans; Metolazone; Natriuresis; Potassium; Protein Binding | 1976 |
Combination of metolazone and furosemide in the treatment of edema in the first month of life.
Topics: Drug Therapy, Combination; Edema; Female; Furosemide; Heart Defects, Congenital; Humans; Infant, New | 1990 |
[Synergistic effect of furosemide and metolazone in edema cases difficult to handle].
Topics: Adult; Diuretics; Drug Synergism; Edema; Furosemide; Humans; Male; Metolazone | 1987 |
Metolazone and furosemide therapy for edema.
Topics: Child; Diuretics; Edema; Furosemide; Humans; Metolazone | 1986 |