metolazone has been researched along with Chronic Kidney Failure in 10 studies
Metolazone: A quinazoline-sulfonamide derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS.
metolazone : A quinazoline that consists of 1,2,3,4-tetrahydroquinazolin-4-one bearing additional methyl, 2-tolyl, sulfamyl and chloro substituents at positions 2, 3, 6 and 7 respectively. A quinazoline diuretic, with properties similar to thiazide diuretics.
| Excerpt | Relevance | Reference |
|---|---|---|
| "4 mg/kg/d) and furosemide (2 to 4 mg/kg/d) in achieving a natriuresis and diuresis was measured in 14 children during 22 episodes of edema resistant to furosemide alone." | 7.67 | Efficacy of metolazone and furosemide in children with furosemide-resistant edema. ( Arnold, WC, 1984) |
| "The effects of the new diuretic metolazone were studied in ten patients with chronic renal insufficiency and ten with nephrotic syndrome." | 7.65 | Long-term diuretic therapy with metolazone of renal failure and the nephrotic syndrome. ( Kane, RE; Paton, RR, 1977) |
| "4 mg/kg/d) and furosemide (2 to 4 mg/kg/d) in achieving a natriuresis and diuresis was measured in 14 children during 22 episodes of edema resistant to furosemide alone." | 3.67 | Efficacy of metolazone and furosemide in children with furosemide-resistant edema. ( Arnold, WC, 1984) |
| "The effects of the new diuretic metolazone were studied in ten patients with chronic renal insufficiency and ten with nephrotic syndrome." | 3.65 | Long-term diuretic therapy with metolazone of renal failure and the nephrotic syndrome. ( Kane, RE; Paton, RR, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (70.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Au, HY | 2 |
| Chan, KY | 2 |
| Yap, DYH | 1 |
| Yip, T | 2 |
| Wong, CY | 1 |
| Cheng, HW | 1 |
| Sham, MK | 1 |
| Li, CW | 1 |
| Groth, H | 2 |
| Vetter, H | 2 |
| Kuhlmann, U | 2 |
| Burger, R | 1 |
| Siegenthaler, W | 2 |
| Vetter, W | 2 |
| Arnold, WC | 1 |
| Farthing, D | 1 |
| Sica, DA | 1 |
| Fakhry, I | 1 |
| Gehr, TW | 1 |
| Bennett, WM | 1 |
| McDonald, WJ | 1 |
| Kuehnel, E | 1 |
| Hartnett, MN | 1 |
| Porter, GA | 1 |
| Kshirsagar, NA | 1 |
| Gupta, KC | 1 |
| Paul, T | 1 |
| Shah, BP | 1 |
| Vora, KK | 1 |
| Sanghvi, B | 1 |
| Acharya, VN | 1 |
| Mehta, JM | 1 |
| Sheth, UK | 1 |
| Paton, RR | 1 |
| Kane, RE | 1 |
| Achermann, R | 1 |
3 trials available for metolazone and Chronic Kidney Failure
| Article | Year |
|---|---|
[Antihypertensive therapy in chronic kidney failure. Comparison of pharmacologic effect of metolazone and furosemide].
Topics: Adult; Aged; Clinical Trials as Topic; Diuretics; Double-Blind Method; Female; Furosemide; Humans; H | 1983 |
Do diuretics have antihypertensive properties independent of natriuresis?
Topics: Adult; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Diuretics; Double-Blind Me | 1977 |
[Diuretics and antihypertensive agents in chronic kidney insufficiency: comparison of the effects of metolazone and furosemide].
Topics: Adult; Aged; Diuretics; Drug Therapy, Combination; Female; Furosemide; Humans; Hydralazine; Hyperten | 1985 |
7 other studies available for metolazone and Chronic Kidney Failure
| Article | Year |
|---|---|
Topics: Conservative Treatment; Furosemide; Heart Failure; Humans; Kidney Failure, Chronic; Metolazone | 2023 |
Combination therapy with low-dose metolazone and furosemide: a "needleless" approach in managing refractory fluid overload in elderly renal failure patients under palliative care.
Topics: Aged; Aged, 80 and over; Diuretics; Drug Therapy, Combination; Edema; Furosemide; Humans; Kidney Fai | 2014 |
Efficacy of metolazone and furosemide in children with furosemide-resistant edema.
Topics: Adolescent; Child; Child, Preschool; Diuresis; Diuretics; Drug Evaluation; Drug Resistance; Drug Syn | 1984 |
Novel high-performance liquid chromatographic method using solid-phase on-line elution for determination of metolazone in plasma and whole blood.
Topics: Chromatography, High Pressure Liquid; Humans; Kidney Failure, Chronic; Male; Metolazone; Reproducibi | 1994 |
Diulo.
Topics: Costs and Cost Analysis; Diuretics; Humans; Hypertension; Kidney Failure, Chronic; Metolazone | 1979 |
Effect of metolazone addition on furosemide resistant cases of edema.
Topics: Adolescent; Adult; Diuretics; Drug Resistance; Drug Therapy, Combination; Edema; Female; Furosemide; | 1978 |
Long-term diuretic therapy with metolazone of renal failure and the nephrotic syndrome.
Topics: Adult; Aged; Antihypertensive Agents; Blood Glucose; Blood Pressure; Body Weight; Creatinine; Diuret | 1977 |