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metolazone and Chronic Kidney Failure

metolazone has been researched along with Chronic Kidney Failure in 10 studies

Metolazone: A quinazoline-sulfonamide derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS.
metolazone : A quinazoline that consists of 1,2,3,4-tetrahydroquinazolin-4-one bearing additional methyl, 2-tolyl, sulfamyl and chloro substituents at positions 2, 3, 6 and 7 respectively. A quinazoline diuretic, with properties similar to thiazide diuretics.

Research Excerpts

ExcerptRelevanceReference
"4 mg/kg/d) and furosemide (2 to 4 mg/kg/d) in achieving a natriuresis and diuresis was measured in 14 children during 22 episodes of edema resistant to furosemide alone."7.67Efficacy of metolazone and furosemide in children with furosemide-resistant edema. ( Arnold, WC, 1984)
"The effects of the new diuretic metolazone were studied in ten patients with chronic renal insufficiency and ten with nephrotic syndrome."7.65Long-term diuretic therapy with metolazone of renal failure and the nephrotic syndrome. ( Kane, RE; Paton, RR, 1977)
"4 mg/kg/d) and furosemide (2 to 4 mg/kg/d) in achieving a natriuresis and diuresis was measured in 14 children during 22 episodes of edema resistant to furosemide alone."3.67Efficacy of metolazone and furosemide in children with furosemide-resistant edema. ( Arnold, WC, 1984)
"The effects of the new diuretic metolazone were studied in ten patients with chronic renal insufficiency and ten with nephrotic syndrome."3.65Long-term diuretic therapy with metolazone of renal failure and the nephrotic syndrome. ( Kane, RE; Paton, RR, 1977)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19907 (70.00)18.7374
1990's1 (10.00)18.2507
2000's0 (0.00)29.6817
2010's1 (10.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
Au, HY2
Chan, KY2
Yap, DYH1
Yip, T2
Wong, CY1
Cheng, HW1
Sham, MK1
Li, CW1
Groth, H2
Vetter, H2
Kuhlmann, U2
Burger, R1
Siegenthaler, W2
Vetter, W2
Arnold, WC1
Farthing, D1
Sica, DA1
Fakhry, I1
Gehr, TW1
Bennett, WM1
McDonald, WJ1
Kuehnel, E1
Hartnett, MN1
Porter, GA1
Kshirsagar, NA1
Gupta, KC1
Paul, T1
Shah, BP1
Vora, KK1
Sanghvi, B1
Acharya, VN1
Mehta, JM1
Sheth, UK1
Paton, RR1
Kane, RE1
Achermann, R1

Trials

3 trials available for metolazone and Chronic Kidney Failure

ArticleYear
[Antihypertensive therapy in chronic kidney failure. Comparison of pharmacologic effect of metolazone and furosemide].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1983, Nov-08, Volume: 72, Issue:45

    Topics: Adult; Aged; Clinical Trials as Topic; Diuretics; Double-Blind Method; Female; Furosemide; Humans; H

1983
Do diuretics have antihypertensive properties independent of natriuresis?
    Clinical pharmacology and therapeutics, 1977, Volume: 22, Issue:5 Pt 1

    Topics: Adult; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Diuretics; Double-Blind Me

1977
[Diuretics and antihypertensive agents in chronic kidney insufficiency: comparison of the effects of metolazone and furosemide].
    Schweizerische medizinische Wochenschrift, 1985, Jan-12, Volume: 115, Issue:2

    Topics: Adult; Aged; Diuretics; Drug Therapy, Combination; Female; Furosemide; Humans; Hydralazine; Hyperten

1985

Other Studies

7 other studies available for metolazone and Chronic Kidney Failure

ArticleYear
    Journal of palliative medicine, 2023, Volume: 26, Issue:2

    Topics: Conservative Treatment; Furosemide; Heart Failure; Humans; Kidney Failure, Chronic; Metolazone

2023
Combination therapy with low-dose metolazone and furosemide: a "needleless" approach in managing refractory fluid overload in elderly renal failure patients under palliative care.
    International urology and nephrology, 2014, Volume: 46, Issue:9

    Topics: Aged; Aged, 80 and over; Diuretics; Drug Therapy, Combination; Edema; Furosemide; Humans; Kidney Fai

2014
Efficacy of metolazone and furosemide in children with furosemide-resistant edema.
    Pediatrics, 1984, Volume: 74, Issue:5

    Topics: Adolescent; Child; Child, Preschool; Diuresis; Diuretics; Drug Evaluation; Drug Resistance; Drug Syn

1984
Novel high-performance liquid chromatographic method using solid-phase on-line elution for determination of metolazone in plasma and whole blood.
    Journal of chromatography. B, Biomedical applications, 1994, Mar-04, Volume: 653, Issue:2

    Topics: Chromatography, High Pressure Liquid; Humans; Kidney Failure, Chronic; Male; Metolazone; Reproducibi

1994
Diulo.
    The Medical letter on drugs and therapeutics, 1979, May-04, Volume: 21, Issue:9

    Topics: Costs and Cost Analysis; Diuretics; Humans; Hypertension; Kidney Failure, Chronic; Metolazone

1979
Effect of metolazone addition on furosemide resistant cases of edema.
    The Journal of the Association of Physicians of India, 1978, Volume: 26, Issue:10

    Topics: Adolescent; Adult; Diuretics; Drug Resistance; Drug Therapy, Combination; Edema; Female; Furosemide;

1978
Long-term diuretic therapy with metolazone of renal failure and the nephrotic syndrome.
    Journal of clinical pharmacology, 1977, Volume: 17, Issue:4

    Topics: Adult; Aged; Antihypertensive Agents; Blood Glucose; Blood Pressure; Body Weight; Creatinine; Diuret

1977