metolazone has been researched along with Body Weight in 12 studies
Metolazone: A quinazoline-sulfonamide derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS.
metolazone : A quinazoline that consists of 1,2,3,4-tetrahydroquinazolin-4-one bearing additional methyl, 2-tolyl, sulfamyl and chloro substituents at positions 2, 3, 6 and 7 respectively. A quinazoline diuretic, with properties similar to thiazide diuretics.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare efficacy and safety of indapamide-furosemide combination against metolazone-furosemide combination in refractory heart failure patients." | 9.30 | Comparing the sodium excreting efficacy of furosemide and indapamide combination against furosemide and metolazone combination in congestive heart failure patients: A randomized control trial. ( Altaf, A; Jan, MU; Salahudin, M; Shah, H, 2019) |
| "17 patients with New York Heart Association (NYHA) class IV congestive cardiac failure, refractory to conventional treatment, were additionally treated with oral metolazone (1." | 9.06 | Metolazone in treatment of severe refractory congestive cardiac failure. ( Arter, WJ; Field, MJ; Kiyingi, A; Lawrence, JR; Pawsey, CC; Yiannikas, J, 1990) |
| "Eighteen patients with hepatic cirrhosis or nephrotic syndrome and having edema and/or ascites were treated during successive periods with metolazone 5 to 40 mg/day, spironolactone 100 mg/day, and with both diuretics concurrently." | 9.04 | Metolazone and spironolactone in cirrhosis and the nephrotic syndrome. ( Arruda, JA; Dhupelia, VB; Kane, RE; Lang, GR; Nascimento, L; Westenfelder, C, 1977) |
| "The effects of the new diuretic metolazone were studied in ten patients with chronic renal insufficiency and ten with nephrotic syndrome." | 7.65 | Long-term diuretic therapy with metolazone of renal failure and the nephrotic syndrome. ( Kane, RE; Paton, RR, 1977) |
| "Metolazone is a potent thiazide-like diuretic." | 6.71 | Combination therapy with metolazone and loop diuretics in outpatients with refractory heart failure: an observational study and review of the literature. ( Galatius, S; Gustafsson, F; Hildebrandt, PR; Rosenberg, J, 2005) |
| "To compare efficacy and safety of indapamide-furosemide combination against metolazone-furosemide combination in refractory heart failure patients." | 5.30 | Comparing the sodium excreting efficacy of furosemide and indapamide combination against furosemide and metolazone combination in congestive heart failure patients: A randomized control trial. ( Altaf, A; Jan, MU; Salahudin, M; Shah, H, 2019) |
| "Ten patients with severe congestive heart failure (6 women and 4 men, aged 67 +/- 4." | 5.27 | Combination of furosemide and metolazone in the treatment of severe congestive heart failure. ( Grosskopf, I; Rabinovitz, M; Rosenfeld, JB, 1986) |
| "Bendrofluazide and metolazone were equally effective in establishing a diuresis in patients with severe congestive cardiac failure resistant to loop diuretics." | 5.07 | Combination diuretic treatment in severe heart failure: a randomised controlled trial. ( Channer, KS; Lawson-Matthew, P; McLean, KA; Richardson, M, 1994) |
| "17 patients with New York Heart Association (NYHA) class IV congestive cardiac failure, refractory to conventional treatment, were additionally treated with oral metolazone (1." | 5.06 | Metolazone in treatment of severe refractory congestive cardiac failure. ( Arter, WJ; Field, MJ; Kiyingi, A; Lawrence, JR; Pawsey, CC; Yiannikas, J, 1990) |
| "Eighteen patients with hepatic cirrhosis or nephrotic syndrome and having edema and/or ascites were treated during successive periods with metolazone 5 to 40 mg/day, spironolactone 100 mg/day, and with both diuretics concurrently." | 5.04 | Metolazone and spironolactone in cirrhosis and the nephrotic syndrome. ( Arruda, JA; Dhupelia, VB; Kane, RE; Lang, GR; Nascimento, L; Westenfelder, C, 1977) |
| "The effects of the new diuretic metolazone were studied in ten patients with chronic renal insufficiency and ten with nephrotic syndrome." | 3.65 | Long-term diuretic therapy with metolazone of renal failure and the nephrotic syndrome. ( Kane, RE; Paton, RR, 1977) |
| "Metolazone is a potent thiazide-like diuretic." | 2.71 | Combination therapy with metolazone and loop diuretics in outpatients with refractory heart failure: an observational study and review of the literature. ( Galatius, S; Gustafsson, F; Hildebrandt, PR; Rosenberg, J, 2005) |
| "Ten patients with severe congestive heart failure (6 women and 4 men, aged 67 +/- 4." | 1.27 | Combination of furosemide and metolazone in the treatment of severe congestive heart failure. ( Grosskopf, I; Rabinovitz, M; Rosenfeld, JB, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (58.33) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Salahudin, M | 1 |
| Shah, H | 1 |
| Jan, MU | 1 |
| Altaf, A | 1 |
| Rosenberg, J | 1 |
| Gustafsson, F | 1 |
| Galatius, S | 1 |
| Hildebrandt, PR | 1 |
| Furrer, J | 1 |
| Hess, OM | 1 |
| Kuhlmann, U | 1 |
| Satz, N | 1 |
| Siegenthaler, W | 1 |
| Chen, Z | 1 |
| Vaughn, DA | 1 |
| Blakely, P | 1 |
| Fanestil, DD | 1 |
| Channer, KS | 1 |
| McLean, KA | 1 |
| Lawson-Matthew, P | 1 |
| Richardson, M | 1 |
| Lang, GR | 1 |
| Westenfelder, C | 1 |
| Nascimento, L | 1 |
| Dhupelia, VB | 1 |
| Arruda, JA | 1 |
| Kane, RE | 3 |
| Werch, A | 1 |
| Van Hoose, MC | 1 |
| Cutler, RE | 1 |
| Paton, RR | 1 |
| Kiyingi, A | 1 |
| Field, MJ | 1 |
| Pawsey, CC | 1 |
| Yiannikas, J | 1 |
| Lawrence, JR | 1 |
| Arter, WJ | 1 |
| Reams, GP | 1 |
| Bauer, JH | 1 |
| Grosskopf, I | 1 |
| Rabinovitz, M | 1 |
| Rosenfeld, JB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy and Tolerability of Combination Intravenous Diuretic Therapy Versus Intravenous Loop Diuretic Therapy Alone for the Treatment of Acute Decompensated Heart Failure[NCT05840536] | Phase 4 | 0 participants (Actual) | Interventional | 2014-05-31 | Withdrawn | ||
| Diuretic Effect of Metolazone Pre-dosing Versus Concurrent Dosing With Furosemide: a Pilot Study[NCT03746002] | Phase 4 | 3 participants (Actual) | Interventional | 2019-01-01 | Terminated (stopped due to Insufficient rate of patient enrollment/accrual.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Total measured urine output in milliliters produced after metolazone dose is given (NCT03746002)
Timeframe: 24 hours
| Intervention | mL (Mean) |
|---|---|
| Metolazone Concurrent Dosing | 2030 |
| Metolazone Pre-dosing | 5650 |
Portion of patients with increase in serum creatinine by ≥ 0.3 mg/dL or ≥ 50% from baseline (NCT03746002)
Timeframe: Baseline and at 12 to 23 hours after metolazone dose
| Intervention | Participants (Count of Participants) |
|---|---|
| Metolazone Concurrent Dosing | 1 |
| Metolazone Pre-dosing | 1 |
Change in serum creatinine from baseline value collected prior to metolazone dose to value collected after metolazone dose (NCT03746002)
Timeframe: Baseline and at 12 to 23 hours after metolazone dose
| Intervention | mg/dL (Mean) |
|---|---|
| Metolazone Concurrent Dosing | 0.45 |
| Metolazone Pre-dosing | 0.38 |
Change in total body weight from baseline value measured prior to metolazone dose to value collected after metolazone dose (NCT03746002)
Timeframe: Baseline and at 12 to 23 hours after metolazone dose
| Intervention | kg (Mean) |
|---|---|
| Metolazone Concurrent Dosing | -.6 |
| Metolazone Pre-dosing | -8.5 |
Proportion of patients with potassium level less than 4.0 mEq/L measured after metolazone dose is given (NCT03746002)
Timeframe: Baseline and at 12 to 23 hours after metolazone dose
| Intervention | Participants (Count of Participants) |
|---|---|
| Metolazone Concurrent Dosing | 0 |
| Metolazone Pre-dosing | 1 |
Proportion of patients with magnesium level less than 2.0 mg/dL measured after metolazone dose is given (NCT03746002)
Timeframe: Baseline and at 12 to 23 hours after metolazone dose
| Intervention | Participants (Count of Participants) |
|---|---|
| Metolazone Concurrent Dosing | 0 |
| Metolazone Pre-dosing | 1 |
Proportion of patients with serum sodium level less than 135 mg/dL measured after metolazone dose is given (NCT03746002)
Timeframe: Baseline and at 12 to 23 hours after metolazone dose
| Intervention | Participants (Count of Participants) |
|---|---|
| Metolazone Concurrent Dosing | 0 |
| Metolazone Pre-dosing | 0 |
7 trials available for metolazone and Body Weight
| Article | Year |
|---|---|
Comparing the sodium excreting efficacy of furosemide and indapamide combination against furosemide and metolazone combination in congestive heart failure patients: A randomized control trial.
Topics: Administration, Intravenous; Administration, Oral; Aged; Body Weight; Diuretics; Drug Therapy, Combi | 2019 |
Combination therapy with metolazone and loop diuretics in outpatients with refractory heart failure: an observational study and review of the literature.
Topics: Aged; Aged, 80 and over; Blood Pressure; Body Weight; Bumetanide; Diuretics; Drug Therapy, Combinati | 2005 |
Combination diuretic treatment in severe heart failure: a randomised controlled trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Bendroflumethiazide; Body Weight; Creatinine; Diuretics; | 1994 |
Metolazone and spironolactone in cirrhosis and the nephrotic syndrome.
Topics: Adult; Aged; Blood Cell Count; Blood Glucose; Blood Pressure; Body Weight; Chlorides; Clinical Trial | 1977 |
Treatment of premenstrual tension with metolazone: a double-blind evaluation of a new diuretic.
Topics: Adolescent; Adult; Body Water; Body Weight; Clinical Trials as Topic; Diuretics; Dose-Response Relat | 1976 |
Antihypertensive efficacy of metolazone (Zaroxolyn) alone and combined with reserpine in treatment of essential hypertension.
Topics: Adult; Aged; Blood Glucose; Blood Pressure; Body Weight; Clinical Trials as Topic; Diuretics; Drug T | 1976 |
Metolazone in treatment of severe refractory congestive cardiac failure.
Topics: Aged; Aged, 80 and over; Body Weight; Clinical Trials as Topic; Diuresis; Diuretics; Dobutamine; Dru | 1990 |
5 other studies available for metolazone and Body Weight
| Article | Year |
|---|---|
[Furosemide and metolazone: a highly effective diuretic combination].
Topics: Ascites; Body Weight; Diuresis; Diuretics; Drug Combinations; Edema, Cardiac; Female; Furosemide; He | 1980 |
Adrenocortical steroids increase renal thiazide diuretic receptor density and response.
Topics: Adrenalectomy; Aldosterone; Androstanols; Animals; Bendroflumethiazide; Body Weight; Carrier Protein | 1994 |
Long-term diuretic therapy with metolazone of renal failure and the nephrotic syndrome.
Topics: Adult; Aged; Antihypertensive Agents; Blood Glucose; Blood Pressure; Body Weight; Creatinine; Diuret | 1977 |
The effect of triple drug therapy on renal function in patients with essential hypertension.
Topics: Adrenergic beta-Antagonists; Aged; Aldosterone; Antihypertensive Agents; Atenolol; Betaxolol; Blood | 1989 |
Combination of furosemide and metolazone in the treatment of severe congestive heart failure.
Topics: Aged; Body Weight; Diuretics; Drug Therapy, Combination; Female; Furosemide; Heart Failure; Humans; | 1986 |