metolazone has been researched along with Blood Pressure, High in 35 studies
Metolazone: A quinazoline-sulfonamide derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS.
metolazone : A quinazoline that consists of 1,2,3,4-tetrahydroquinazolin-4-one bearing additional methyl, 2-tolyl, sulfamyl and chloro substituents at positions 2, 3, 6 and 7 respectively. A quinazoline diuretic, with properties similar to thiazide diuretics.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study compared the incidence of cough with the angiotensin-converting enzyme (ACE) inhibitor lisinopril and the diuretic metolazone with angiotensin II receptor antagonist losartan in elderly hypertensive patients with previous histories of ACE inhibitor-induced cough." | 9.08 | Double-blind comparison of losartan, lisinopril, and metolazone in elderly hypertensive patients with previous angiotensin-converting enzyme inhibitor-induced cough. ( Chan, P; Huang, TY; Ko, JT; Lee, YS; Lin, TS; Tomlinson, B, 1997) |
| "Two multicenter, double-blind, randomized studies were performed to determine the antihypertensive efficacy and effects on laboratory values of a new, shorter-acting formulation of metolazone in patients with mild to moderate hypertension." | 9.06 | Clinical studies of a new, low-dose formulation of metolazone for the treatment of hypertension. ( Curry, CL; Harris, R; Janda, SM; MacKay, JH; Nugent, CA; Ryan, J; Schnaper, H; Schoenberger, J, 1986) |
| " A cross-over study was done in twenty patients with hypertension to compare the effects of chlorothiazide (0-5 g twice daily) and metolazone (5 mg daily) in combination with other anti-hypertensive agents." | 9.04 | A comparison of the effects of chlorothiazide and of metolazone in the treatment of hypertension. ( Hua, AS; Kincaid-Smith, P, 1976) |
| "Metolazone-induced acute pancreatitis and hypercalcemia are described in a 58-year-old woman with severe congestive cardiac failure." | 7.68 | Case report: metolazone-associated hypercalcemia and acute pancreatitis. ( Anderson, PE; Austin, SM; Ellis, GG, 1991) |
| "To evaluate the role of the renin-angiotensin system and sodium depletion in the hypotensive response to 1-sarcosine-8-alanine-angiotensin II (saralasin), 15 male patients with essential hypertension were studied on a diet containing 120 mEq of sodium and 100 mEq of potassium per day." | 7.66 | Angiotensin II, plasma renin and sodium depletion as determinants of blood pressure response to saralasin in essential hypertension. ( Barrett, JD; Eggena, P; Golub, MS; Sambhi, MP; Thananopavarn, C, 1980) |
| "This study compared the incidence of cough with the angiotensin-converting enzyme (ACE) inhibitor lisinopril and the diuretic metolazone with angiotensin II receptor antagonist losartan in elderly hypertensive patients with previous histories of ACE inhibitor-induced cough." | 5.08 | Double-blind comparison of losartan, lisinopril, and metolazone in elderly hypertensive patients with previous angiotensin-converting enzyme inhibitor-induced cough. ( Chan, P; Huang, TY; Ko, JT; Lee, YS; Lin, TS; Tomlinson, B, 1997) |
| "Two multicenter, double-blind, randomized studies were performed to determine the antihypertensive efficacy and effects on laboratory values of a new, shorter-acting formulation of metolazone in patients with mild to moderate hypertension." | 5.06 | Clinical studies of a new, low-dose formulation of metolazone for the treatment of hypertension. ( Curry, CL; Harris, R; Janda, SM; MacKay, JH; Nugent, CA; Ryan, J; Schnaper, H; Schoenberger, J, 1986) |
| " A cross-over study was done in twenty patients with hypertension to compare the effects of chlorothiazide (0-5 g twice daily) and metolazone (5 mg daily) in combination with other anti-hypertensive agents." | 5.04 | A comparison of the effects of chlorothiazide and of metolazone in the treatment of hypertension. ( Hua, AS; Kincaid-Smith, P, 1976) |
| "Metolazone-induced acute pancreatitis and hypercalcemia are described in a 58-year-old woman with severe congestive cardiac failure." | 3.68 | Case report: metolazone-associated hypercalcemia and acute pancreatitis. ( Anderson, PE; Austin, SM; Ellis, GG, 1991) |
| "To evaluate the role of the renin-angiotensin system and sodium depletion in the hypotensive response to 1-sarcosine-8-alanine-angiotensin II (saralasin), 15 male patients with essential hypertension were studied on a diet containing 120 mEq of sodium and 100 mEq of potassium per day." | 3.66 | Angiotensin II, plasma renin and sodium depletion as determinants of blood pressure response to saralasin in essential hypertension. ( Barrett, JD; Eggena, P; Golub, MS; Sambhi, MP; Thananopavarn, C, 1980) |
| "In two patients with severe hypertension and moderately severe renal insufficiency, metolazone and furosemide were used in combination with propranolol, methyldopa, and hydralazine to augment control of blood pressure." | 3.66 | Severe electrolyte disturbances associated with metolazone and furosemide. ( Black, WD; Roman, J; Shiner, PT, 1978) |
| ") were followed monthly in patients with essential hypertension on metolazone, 5 mg daily for three months and with added propranolol, 40 to 160 mg, for the subsequent three months." | 3.65 | Antihypertensive and renin angiotensin effects of metolazone with and without propranolol. ( Barrett, JD; Eggena, P; Sambhi, MP; Thananopavarn, C; Tuck, M; Wiedman, C, 1977) |
| " The side-effect score for edema was lower with ISR plus diuretics than with other combinations, whereas the ACE inhibitor was associated with a higher score for cough." | 2.67 | Efficacy and safety of various combination therapies based on a calcium antagonist in essential hypertension: results of a placebo-controlled randomized trial. ( Lüscher, TF; Waeber, B, 1993) |
| "5 mg/day of metolazone or 25 mg/day of chlorthalidone are effective antihypertensive agents but that blood pressure lowering may be inconsistent at these dosage levels." | 2.66 | Low-dose diuretic therapy for hypertension. ( Moser, M, 1986) |
| " Plasma renin concentration and the aortic renin content of the spontaneously hypertensive rat showed divergent changes in response to a blood pressure fall associated with acute diuretic therapy, chronic administration of hydrallazine and in some animals in response to chronic administration of propranolol." | 1.26 | Partial characterization of aortic renin in the spontaneously hypertensive rat and its interrelationship with plasma renin, blood pressure and sodium balance. ( Barrett, JD; Eggena, P; Sambhi, MP, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (85.71) | 18.7374 |
| 1990's | 4 (11.43) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (2.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kasai, T | 1 |
| Bradley, TD | 1 |
| Friedman, O | 1 |
| Logan, AG | 1 |
| Groth, H | 1 |
| Vetter, H | 1 |
| Kuhlmann, U | 1 |
| Burger, R | 1 |
| Siegenthaler, W | 1 |
| Vetter, W | 1 |
| Thananopavarn, C | 2 |
| Golub, MS | 1 |
| Eggena, P | 3 |
| Barrett, JD | 3 |
| Sambhi, MP | 3 |
| Hickey, N | 1 |
| O'Donoghue, S | 1 |
| Guiry, U | 1 |
| Graham, I | 1 |
| Mulcahy, R | 1 |
| Belton, P | 1 |
| Carmody, M | 1 |
| Sheridan, J | 1 |
| Quigley, P | 1 |
| Jackson, M | 1 |
| Winchester, JF | 1 |
| Kellett, RJ | 1 |
| Boddy, K | 1 |
| Boyle, P | 1 |
| Dargie, HJ | 1 |
| Mahaffey, ME | 1 |
| Ward, DM | 1 |
| Kennedy, AC | 1 |
| Lüscher, TF | 1 |
| Waeber, B | 1 |
| Chan, P | 1 |
| Tomlinson, B | 1 |
| Huang, TY | 1 |
| Ko, JT | 1 |
| Lin, TS | 1 |
| Lee, YS | 1 |
| Ward, W | 1 |
| Abetel, G | 1 |
| Allenbach, C | 1 |
| Chapuis, P | 1 |
| Christeler, P | 1 |
| Delacrétaz, B | 1 |
| Karly, M | 1 |
| Magnenat, G | 1 |
| Morandi, D | 1 |
| Muhlbauer, MA | 1 |
| de Senarciens, B | 1 |
| Terrier, P | 1 |
| Troillet, F | 1 |
| Suh, K | 1 |
| Sood, R | 1 |
| Hoyt, JL | 1 |
| Rhomberg, F | 1 |
| Bächtold, H | 1 |
| Danczkay, I | 1 |
| Dubi, A | 1 |
| Fetscherin, R | 1 |
| Kälin, R | 1 |
| Knuchel, HR | 1 |
| Lauper, N | 1 |
| Mannhart, M | 1 |
| Müller, T | 1 |
| Pugatsch, I | 1 |
| Renggli, I | 1 |
| Schäublin, A | 1 |
| Spillmann, B | 1 |
| Veraguth, F | 1 |
| Walther, P | 1 |
| Black, WD | 1 |
| Shiner, PT | 1 |
| Roman, J | 1 |
| Dornfeld, L | 1 |
| Kane, RE | 1 |
| Van Hoose, MC | 1 |
| Cutler, RE | 1 |
| Weingarten, C | 1 |
| Cangiano, JL | 1 |
| Benedetto, ER | 1 |
| Tuck, M | 1 |
| Wiedman, C | 1 |
| Thompson, DM | 1 |
| Nichols, TO | 1 |
| Kessler, FO | 1 |
| Hua, AS | 1 |
| Kincaid-Smith, P | 1 |
| Anderson, PE | 1 |
| Ellis, GG | 1 |
| Austin, SM | 1 |
| Beaumont, K | 1 |
| Vaughn, DA | 1 |
| Casto, R | 1 |
| Printz, MP | 1 |
| Fanestil, DD | 1 |
| Reams, GP | 1 |
| Bauer, JH | 1 |
| Basso, B | 1 |
| Gac, JC | 1 |
| Rebolledo, H | 1 |
| Román, O | 1 |
| Valenzuela, MA | 1 |
| Cespedes, E | 1 |
| Curry, CL | 1 |
| Janda, SM | 1 |
| Harris, R | 1 |
| MacKay, JH | 1 |
| Nugent, CA | 1 |
| Ryan, J | 1 |
| Schnaper, H | 1 |
| Schoenberger, J | 1 |
| Moser, M | 1 |
| Miller, SA | 1 |
| Cobb, SD | 1 |
| Petrulis, AS | 1 |
| Vertes, V | 1 |
| Rowe, PA | 1 |
| Mather, HG | 1 |
14 trials available for metolazone and Blood Pressure, High
| Article | Year |
|---|---|
[Antihypertensive therapy in chronic kidney failure. Comparison of pharmacologic effect of metolazone and furosemide].
Topics: Adult; Aged; Clinical Trials as Topic; Diuretics; Double-Blind Method; Female; Furosemide; Humans; H | 1983 |
Metolazone and pindolol in the treatment of hypertension: a double blind multicentre trial.
Topics: Aged; Clinical Trials as Topic; Diuretics; Double-Blind Method; Female; Humans; Hypertension; Male; | 1982 |
Metolazone and bendroflumethiazide in hypertension: physiologic and metabolic observations.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Bendroflumethiazide; Blood Pressure; Diuretics; Fe | 1980 |
Efficacy and safety of various combination therapies based on a calcium antagonist in essential hypertension: results of a placebo-controlled randomized trial.
Topics: Adrenergic beta-Antagonists; Aged; Calcium Channel Blockers; Double-Blind Method; Drug Therapy, Comb | 1993 |
Double-blind comparison of losartan, lisinopril, and metolazone in elderly hypertensive patients with previous angiotensin-converting enzyme inhibitor-induced cough.
Topics: Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzothi | 1997 |
[Metolazone in arterial hypertension. Multi-centric study with 2.5 mg of Zaroxolyne (metolazone) taken in a single daily dose].
Topics: Adult; Aged; Antihypertensive Agents; Clinical Trials as Topic; Diuretics; Drug Evaluation; Drug Tol | 1978 |
[Treatment of hypertension with metolazone in general practice - a joint study (author's transl)].
Topics: Adult; Aged; Diuretics; Drug Evaluation; Female; Humans; Hypertension; Male; Metolazone; Middle Aged | 1979 |
Metolazone in essential hypertension: the long-term clinical efficacy of a new diuretic.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Diuretics; Female; Heart Rate; Humans; Hypert | 1975 |
Antihypertensive efficacy of metolazone (Zaroxolyn) alone and combined with reserpine in treatment of essential hypertension.
Topics: Adult; Aged; Blood Glucose; Blood Pressure; Body Weight; Clinical Trials as Topic; Diuretics; Drug T | 1976 |
A comparison of the effects of chlorothiazide and of metolazone in the treatment of hypertension.
Topics: Adult; Aged; Chlorothiazide; Diuretics; Female; Humans; Hypertension; Male; Metolazone; Middle Aged; | 1976 |
[Metolazone, a new diuretic in essential arterial hypertension].
Topics: Adult; Aged; Blood Glucose; Blood Pressure; Clinical Trials as Topic; Diuretics; Female; Heart Rate; | 1986 |
Clinical studies of a new, low-dose formulation of metolazone for the treatment of hypertension.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Diuretics; Double-Blind Method; Female; Human | 1986 |
Low-dose diuretic therapy for hypertension.
Topics: Chlorthalidone; Diuretics; Dose-Response Relationship, Drug; Double-Blind Method; Electrolytes; Fema | 1986 |
Step 1 1/2 therapy for the treatment of hypertension.
Topics: Antihypertensive Agents; Clinical Trials as Topic; Diuretics; Drug Combinations; Female; Humans; Hyd | 1985 |
21 other studies available for metolazone and Blood Pressure, High
| Article | Year |
|---|---|
Effect of intensified diuretic therapy on overnight rostral fluid shift and obstructive sleep apnoea in patients with uncontrolled hypertension.
Topics: Aged; Blood Pressure; Diuretics; Drug Resistance; Drug Therapy, Combination; Extracellular Fluid; Fe | 2014 |
Angiotensin II, plasma renin and sodium depletion as determinants of blood pressure response to saralasin in essential hypertension.
Topics: Adult; Aged; Angiotensin II; Blood Pressure; Dose-Response Relationship, Drug; Drug Therapy, Combina | 1980 |
Metolazone therapy of patients with mild to moderate hypertension.
Topics: Adult; Aged; Diuretics; Female; Humans; Hypertension; Male; Metolazone; Middle Aged | 1977 |
Hypoplastic anemia associated with metolazone.
Topics: Aged; Anemia, Aplastic; Diuretics; Female; Humans; Hypertension; Metolazone | 1979 |
Diulo.
Topics: Costs and Cost Analysis; Diuretics; Humans; Hypertension; Kidney Failure, Chronic; Metolazone | 1979 |
Metolazone for effective blood pressure reduction and diuresis.
Topics: Adult; Aged; Diuretics; Edema; Female; Humans; Hypertension; Male; Metolazone; Middle Aged | 1979 |
Severe electrolyte disturbances associated with metolazone and furosemide.
Topics: Adult; Aged; Diuretics; Drug Therapy, Combination; Female; Furosemide; Heart Failure; Humans; Hypert | 1978 |
Partial characterization of aortic renin in the spontaneously hypertensive rat and its interrelationship with plasma renin, blood pressure and sodium balance.
Topics: Angiotensin I; Animals; Aorta; Blood Pressure; Female; Hydralazine; Hypertension; Male; Metolazone; | 1978 |
Metolazone for hypertension?
Topics: Diuretics; Humans; Hypertension; Metolazone | 1978 |
Clinical evaluation of metolazone, a long-acting antihypertensive/diuretic.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Diuretics; Drug Evaluation; Drug Therapy, Comb | 1976 |
Effects of prolonged administration of metolazone in the treatment of essential hypertension.
Topics: Administration, Oral; Adult; Antihypertensive Agents; Blood Pressure; Cholesterol; Depression, Chemi | 1976 |
Use of metolazone in the treatment of refractory hypertension.
Topics: Adult; Aged; Diuretics; Female; Humans; Hypertension; Male; Metolazone; Middle Aged | 1977 |
Antihypertensive and renin angiotensin effects of metolazone with and without propranolol.
Topics: Angiotensin II; Antihypertensive Agents; Blood Pressure; Diuretics; Drug Interactions; Drug Therapy, | 1977 |
A new antihypertensive: metolazone treatment of hypertension.
Topics: Aged; Diuretics; Female; Humans; Hypertension; Male; Metolazone; Middle Aged | 1977 |
Initial experience with metolazone. Well tolerated new antihypertensive agent.
Topics: Adult; Aged; Diuretics; Dose-Response Relationship, Drug; Drug Tolerance; Female; Humans; Hypertensi | 1977 |
Effective blood pressure reduction and diuresis with metolazone.
Topics: Adult; Aged; Diuretics; Female; Humans; Hypertension; Male; Metolazone; Middle Aged | 1976 |
Case report: metolazone-associated hypercalcemia and acute pancreatitis.
Topics: Acute Disease; Female; Heart Failure; Humans; Hypercalcemia; Hypertension; Metolazone; Middle Aged; | 1991 |
Thiazide diuretic receptors in spontaneously hypertensive rats and 2-kidney 1-clip hypertensive rats.
Topics: Animals; Carrier Proteins; Female; Hypertension; Hypertension, Renovascular; Kidney; Male; Metolazon | 1990 |
The effect of triple drug therapy on renal function in patients with essential hypertension.
Topics: Adrenergic beta-Antagonists; Aged; Aldosterone; Antihypertensive Agents; Atenolol; Betaxolol; Blood | 1989 |
Microx.
Topics: Diuretics; Humans; Hypertension; Hypokalemia; Metolazone | 1988 |
Hyperosmolar non-ketotic diabetes mellitus associated with metolazone.
Topics: Diabetic Coma; Diuretics; Female; Humans; Hyperglycemic Hyperosmolar Nonketotic Coma; Hypertension; | 1985 |