metoclopramide has been researched along with Schizophrenia in 20 studies
Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.
metoclopramide : A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.
Schizophrenia: A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.
| Excerpt | Relevance | Reference |
|---|---|---|
| "It is reported in this article that a good curative effect was obtained when 25 schizophrenia patients were treated with 572 +/- 174(mg/day) metoclopramide." | 7.68 | [Curative effect observation and plasma level determination in treating schizophrenia with the higher dose metoclopramide]. ( Gu, SF, 1990) |
| " Dosage of these two drugs were 450 = 133 mg and 32 +/- 9." | 6.67 | [A double-blind study of metoclopramide in the treatment of schizophrenia and determination of prolactin]. ( Gu, SF, 1992) |
| "It is reported in this article that a good curative effect was obtained when 25 schizophrenia patients were treated with 572 +/- 174(mg/day) metoclopramide." | 3.68 | [Curative effect observation and plasma level determination in treating schizophrenia with the higher dose metoclopramide]. ( Gu, SF, 1990) |
| " Furthermore, to evaluate whether high circulating PRL levels influence the activity of the opioid system after the menopause, a group of seven postmenopausal subjects was tested before and 1 week after the administration of metoclopramide (10 mg, three times a day), a dopamine receptor antagonist." | 3.67 | Differences in the opioid control of luteinizing hormone secretion between pathological and iatrogenic hyperprolactinemic states. ( Brambilla, F; De Leo, V; Facchinetti, F; Genazzani, AR; Montemagno, U; Nappi, C; Petraglia, F, 1987) |
| "Metoclopramide was found to be safe and effective for the treatment of HAC." | 2.82 | Double-Blind, Randomized, Placebo-Controlled Trial of Metoclopramide for Hypersalivation Associated With Clozapine. ( Bergman, J; Bersudsky, Y; Gaiduk, Y; Kreinin, A; Lerner, PP; Lerner, V; Miodownik, C; Mirkin, V; Yankovsky, Y, 2016) |
| " Dosage of these two drugs were 450 = 133 mg and 32 +/- 9." | 2.67 | [A double-blind study of metoclopramide in the treatment of schizophrenia and determination of prolactin]. ( Gu, SF, 1992) |
| "Metoclopramide is a substituted benzamide derivative, structurally similar to procainamide and sulpiride." | 1.26 | Metoclopramide: antipsychotic efficacy of a drug lacking potency in receptor models. ( Gershon, S; Kleinberg, D; Lautin, A; Rotrosen, J; Stanley, M, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (55.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 1 (5.00) | 29.6817 |
| 2010's | 5 (25.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Livermore, C | 1 |
| White, H | 1 |
| Bailey, L | 1 |
| Osborne, I | 1 |
| Oloyede, E | 1 |
| Dzahini, O | 1 |
| Whiskey, E | 1 |
| Merrill, RM | 1 |
| Lyon, JL | 1 |
| Matiaco, PM | 1 |
| Kreinin, A | 1 |
| Miodownik, C | 1 |
| Mirkin, V | 1 |
| Gaiduk, Y | 1 |
| Yankovsky, Y | 1 |
| Bersudsky, Y | 1 |
| Lerner, PP | 1 |
| Bergman, J | 1 |
| Lerner, V | 1 |
| de Jong, S | 1 |
| Vidler, LR | 1 |
| Mokrab, Y | 1 |
| Collier, DA | 1 |
| Breen, G | 1 |
| Hallahan, B | 1 |
| Levin, R | 1 |
| Calzavara, MB | 1 |
| Santos, CM | 1 |
| Medrano, WA | 1 |
| Niigaki, ST | 1 |
| Abílio, VC | 1 |
| Stanley, M | 4 |
| Lautin, A | 3 |
| Rotrosen, J | 3 |
| Gershon, S | 4 |
| Kleinberg, D | 1 |
| Pi, EH | 1 |
| Simpson, GM | 1 |
| Wazer, D | 3 |
| Cross, AJ | 1 |
| Ferrier, IN | 1 |
| Bloxham, CA | 1 |
| Kropp, S | 1 |
| Hauser, U | 1 |
| Emrich, HM | 1 |
| Grohmann, R | 1 |
| Wilson, JD | 1 |
| King, DJ | 1 |
| Sheridan, B | 1 |
| Angrist, B | 1 |
| Thompson, H | 1 |
| Shopsin, B | 1 |
| Gu, SF | 2 |
| Doongaji, DR | 1 |
| Desai, AB | 1 |
| Satoskar, RS | 1 |
| Petraglia, F | 1 |
| De Leo, V | 1 |
| Nappi, C | 1 |
| Facchinetti, F | 1 |
| Montemagno, U | 1 |
| Brambilla, F | 1 |
| Genazzani, AR | 1 |
| Hietala, J | 1 |
| Koulu, M | 1 |
| Scheinin, M | 1 |
| Syvälahti, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Metoclopramide as Treatment of Clozapine-induced Hypersalivation[NCT02222220] | Phase 3 | 61 participants (Actual) | Interventional | 2012-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metoclopramide and Schizophrenia
| Article | Year |
|---|---|
Atypical neuroleptics: clozapine and the benzamides in the prevention and treatment of tardive dyskinesia.
Topics: Antipsychotic Agents; Benzamides; Clinical Trials as Topic; Clozapine; Dibenzazepines; Dose-Response | 1983 |
3 trials available for metoclopramide and Schizophrenia
| Article | Year |
|---|---|
Double-Blind, Randomized, Placebo-Controlled Trial of Metoclopramide for Hypersalivation Associated With Clozapine.
Topics: Adult; Antipsychotic Agents; Clozapine; Dopamine D2 Receptor Antagonists; Double-Blind Method; Human | 2016 |
Atypical neuroleptics: clozapine and the benzamides in the prevention and treatment of tardive dyskinesia.
Topics: Antipsychotic Agents; Benzamides; Clinical Trials as Topic; Clozapine; Dibenzazepines; Dose-Response | 1983 |
[A double-blind study of metoclopramide in the treatment of schizophrenia and determination of prolactin].
Topics: Adolescent; Adult; Basal Ganglia Diseases; Double-Blind Method; Female; Haloperidol; Humans; Male; M | 1992 |
17 other studies available for metoclopramide and Schizophrenia
| Article | Year |
|---|---|
A retrospective case notes review of the effectiveness and tolerability of metoclopramide in the treatment of clozapine-induced hypersalivation (CIH).
Topics: Antipsychotic Agents; Clozapine; Humans; Metoclopramide; Retrospective Studies; Schizophrenia; Sialo | 2022 |
Tardive and spontaneous dyskinesia incidence in the general population.
Topics: Adult; Antipsychotic Agents; Dyskinesia, Drug-Induced; Dyskinesias; Female; Humans; Incidence; Male; | 2013 |
Gene-set analysis based on the pharmacological profiles of drugs to identify repurposing opportunities in schizophrenia.
Topics: Antipsychotic Agents; Drug Design; Drug Repositioning; Genetic Predisposition to Disease; Genome-Wid | 2016 |
Metoclopramide may be effective for clozapine-induced hypersalivation.
Topics: Antipsychotic Agents; Clozapine; Humans; Metoclopramide; Schizophrenia; Sialorrhea | 2016 |
Spontaneously Hypertensive Rats (SHR) present deficits in prepulse inhibition of startle specifically reverted by clozapine.
Topics: Acoustic Stimulation; Amphetamine; Animals; Antimanic Agents; Antipsychotic Agents; Carbamazepine; C | 2011 |
Metoclopramide: antipsychotic efficacy of a drug lacking potency in receptor models.
Topics: Antipsychotic Agents; Humans; Metoclopramide; Models, Biological; Prolactin; Receptors, Dopamine; Sc | 1980 |
Discrimination of functionally heterogeneous receptor subpopulations: antipsychotic and antidopaminergic properties of metoclopramide [proceedings].
Topics: Animals; Apomorphine; Binding Sites; Humans; Metoclopramide; Rats; Receptors, Dopamine; Receptors, N | 1981 |
High plasma concentrations of metoclopramide are not detected by radioreceptor assay.
Topics: Animals; Corpus Striatum; Dose-Response Relationship, Drug; Humans; Male; Metoclopramide; Prolactin; | 1983 |
Dopamine D1 receptors in human parathyroid gland: in vitro and in vivo studies.
Topics: Adult; Apomorphine; Flupenthixol; Humans; Male; Metoclopramide; Parathyroid Glands; Parathyroid Horm | 1983 |
Metoclopramide-related pisa syndrome in clozapine treatment.
Topics: Clozapine; Dopamine Antagonists; Dyskinesia, Drug-Induced; Female; Humans; Metoclopramide; Middle Ag | 2001 |
Tardive dyskinesia and metoclopramide.
Topics: Animals; Dyskinesia, Drug-Induced; Humans; Metoclopramide; Rats; Schizophrenia | 1979 |
Plasma prolactin levels before and during propranolol treatment in chronic schizophrenia.
Topics: Chronic Disease; Humans; Male; Metoclopramide; Prolactin; Propranolol; Psychiatric Status Rating Sca | 1979 |
Clinical studies with dopamine-receptor stimulants.
Topics: Adult; Apomorphine; Blood Pressure; Dopamine; Female; Hallucinations; Humans; Male; Metoclopramide; | 1975 |
[Curative effect observation and plasma level determination in treating schizophrenia with the higher dose metoclopramide].
Topics: Adolescent; Adult; Female; Humans; Metoclopramide; Middle Aged; Schizophrenia | 1990 |
Metoclopramide in schizophrenia (an open study).
Topics: Adolescent; Adult; Brief Psychiatric Rating Scale; Female; Humans; Male; Metoclopramide; Middle Aged | 1986 |
Differences in the opioid control of luteinizing hormone secretion between pathological and iatrogenic hyperprolactinemic states.
Topics: Adenoma; Adult; Amenorrhea; Antipsychotic Agents; Dopamine Antagonists; Endorphins; Female; Humans; | 1987 |
Neuroendocrine aspects in monitoring of dopaminergic drugs in man.
Topics: Apomorphine; Bromocriptine; Growth Hormone; Homovanillic Acid; Humans; Levodopa; Male; Metoclopramid | 1985 |