metoclopramide has been researched along with Recrudescence in 25 studies
Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.
metoclopramide : A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We compare metoclopramide 20 mg intravenously, combined with diphenhydramine 25 mg intravenously, with ketorolac 30 mg intravenously in adults with tension-type headache and all nonmigraine, noncluster recurrent headaches." | 9.17 | A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches. ( Adewunmi, V; Bijur, PE; Campbell, C; Esses, D; Friedman, BW; Gallagher, EJ; Solorzano, C, 2013) |
| "The effect of metoclopramide as an adjunct to the conventional treatment of gastric bezoars was studied." | 9.05 | Metoclopramide in the treatment of gastric bezoars. ( Saleh, J; Winkler, WP, 1983) |
| "We compare metoclopramide 20 mg intravenously, combined with diphenhydramine 25 mg intravenously, with ketorolac 30 mg intravenously in adults with tension-type headache and all nonmigraine, noncluster recurrent headaches." | 5.17 | A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches. ( Adewunmi, V; Bijur, PE; Campbell, C; Esses, D; Friedman, BW; Gallagher, EJ; Solorzano, C, 2013) |
| "The effect of metoclopramide as an adjunct to the conventional treatment of gastric bezoars was studied." | 5.05 | Metoclopramide in the treatment of gastric bezoars. ( Saleh, J; Winkler, WP, 1983) |
| " There were 28 patients in group I whose major presenting sign was recurrent pneumonia due to GER, and 22 patients in group II, with apnea caused by GER." | 3.67 | Gastroesophageal reflux. pH probe-directed therapy. ( Curreri, PW; Powell, RW; Ramenofsky, ML, 1986) |
| " Antiemetic effect of prochlorperazine (PCZ) is diminished by its low bioavailability owing to a significant gastric and hepatic first pass effect." | 2.69 | Evaluation of prochlorperazine buccal tablets (Bukatel) and metoclopramide oral tablets in the treatment of acute emesis. ( Chaudhary, A; Sharma, DR; Singh, S, 1999) |
| "The majority of children with migraines are successfully discharged from the ED and only 1 in 18 required a revisit within 3 days." | 1.42 | A comparison of acute treatment regimens for migraine in the emergency department. ( Bachur, RG; Monuteaux, MC; Neuman, MI, 2015) |
| "Chest pain is an alarming symptom; it justifies many visits to the emergency department (ED)." | 1.40 | Chest pain a manifestation of migraine. ( Roldan, CJ, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (56.00) | 18.7374 |
| 1990's | 8 (32.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (12.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Friedman, BW | 1 |
| Adewunmi, V | 1 |
| Campbell, C | 1 |
| Solorzano, C | 1 |
| Esses, D | 1 |
| Bijur, PE | 1 |
| Gallagher, EJ | 1 |
| Roldan, CJ | 1 |
| Bachur, RG | 1 |
| Monuteaux, MC | 1 |
| Neuman, MI | 1 |
| Delpre, G | 1 |
| Kadish, U | 1 |
| Glanz, I | 1 |
| Winkler, WP | 1 |
| Saleh, J | 1 |
| Berndt, H | 1 |
| Otto, R | 1 |
| Reuss, D | 1 |
| Ungureanu, D | 1 |
| Brătucu, E | 1 |
| Ulmeanu, D | 1 |
| Bota, D | 1 |
| Dragoncea, C | 1 |
| Anaya Ordóñez, S | 1 |
| Matas Hoces, A | 1 |
| Graf, WD | 1 |
| Riback, PS | 1 |
| Harrington, ML | 1 |
| Moore, MP | 1 |
| Talcott, PA | 1 |
| Bagley, RS | 1 |
| Sandmeier, P | 1 |
| Mukhopadhyay, K | 1 |
| Narang, A | 1 |
| Kumar, P | 1 |
| Chakraborty, S | 1 |
| Mittal, BR | 1 |
| Singh, S | 1 |
| Sharma, DR | 1 |
| Chaudhary, A | 1 |
| Langman, MJ | 1 |
| Leonhardt, L | 1 |
| Morgan, AG | 1 |
| McAdam, WA | 1 |
| Pyrah, RD | 1 |
| Tinsley, EG | 1 |
| Salim, AS | 1 |
| Tsimmerman, IaS | 1 |
| Ivanova, VS | 1 |
| Modestova, EV | 1 |
| Rotenberg, GB | 1 |
| Sato, T | 1 |
| Igarashi, N | 1 |
| Minami, S | 1 |
| Okabe, T | 1 |
| Hashimoto, H | 1 |
| Hasui, M | 1 |
| Kato, E | 1 |
| Lieberman, DA | 1 |
| Sørensen, TT | 1 |
| Sørensen, PS | 1 |
| Ramenofsky, ML | 1 |
| Powell, RW | 1 |
| Curreri, PW | 1 |
| Gordon, D | 1 |
| Richards, A | 1 |
| Bulloch, R | 1 |
| Cohen, HN | 1 |
| Semple, CG | 1 |
| Beastall, GH | 1 |
| Thomson, JA | 1 |
| Teasdale, G | 1 |
| Masterton, G | 1 |
| Schofield, CB | 1 |
| Tait, IB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An RCT of Metoclopramide/Diphenhydramine vs. Ketorolac Alone for Tension-type Headache[NCT01011673] | Phase 4 | 123 participants (Actual) | Interventional | 2009-11-30 | Completed | ||
| The Check Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine. A Multi-Center, Randomized Double-Blind, Clinical Control Trial.[NCT02657031] | Phase 4 | 54 participants (Actual) | Interventional | 2016-03-17 | Completed | ||
| A Randomized Double-blind Comparative Efficacy Trial of IV Acetaminophen Versus IV Ketorolac for Emergency Department Treatment of Generalized Headache[NCT03472872] | Phase 4 | 500 participants (Actual) | Interventional | 2017-09-05 | Terminated (stopped due to no longer recruiting or studying) | ||
| Intravenous Fluids in Benign Headaches Trail: A Randomized Single Blind Clinical Trial[NCT03185130] | Phase 4 | 58 participants (Actual) | Interventional | 2017-05-16 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
At baseline at at 60 minutes, all patients were asked to describe their pain on a scale from 0 to 10, with 0 representing no pain and 10 the worst imaginable. The primary outcome is the 60 minute score subtracted from the baseline score (NCT01011673)
Timeframe: Baseline, 60 minutes
| Intervention | units on a scale (Mean) |
|---|---|
| Ketorolac | 3.8 |
| Metoclopramide | 5.1 |
"24 hours after the emergency department visit, patients were asked, The next time you come to the Er with this type of headache, do you want to receive the same medication? Affirmative answers are tabulated here." (NCT01011673)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Ketorolac | 45 |
| Metoclopramide | 53 |
Reduction in 100 mm Visual Analog Scale (VAS) Score. The maximum possible change in VAS score is 100 mm, representing the complete relief of maximum anxiety. A change of 0 mm corresponds to no change in anxiety level, and a negative value indicates worsening of the anxiety after the medication. (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | mm (Mean) |
|---|---|
| Control Arm | 33.7 |
| Study Arm | 21.2 |
Reduction in 100 mm Visual Analog Scale (VAS) Score. Positive values represent a reduction in headache severity. The maximum possible change in VAS score is 100 mm, representing the complete relief of a maximally severe headache. A change of 0 mm corresponds to no change in headache severity, and a negative value indicates worsening of the headache after the medication. (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | mm (Mean) |
|---|---|
| Control Arm | 63.5 |
| Study Arm | 43.5 |
Reduction in 100 mm Visual Analog Scale (VAS) Score. The maximum possible change in VAS score is 100 mm, representing the complete relief of maximum nausea. A change of 0 mm corresponds to no change in nausea level, and a negative value indicates worsening of the nausea after the medication. (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | mm (Mean) |
|---|---|
| Control Arm | 38.9 |
| Study Arm | 22.9 |
Yes/No (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | participants (Number) |
|---|---|
| Control Arm | 2 |
| Study Arm | 3 |
Yes/No (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | participants (Number) |
|---|---|
| Control Arm | 3 |
| Study Arm | 3 |
2 reviews available for metoclopramide and Recrudescence
| Article | Year |
|---|---|
Pharmacologic treatment of recurrent pediatric headache.
Topics: Acetaminophen; Adolescent; Adrenal Cortex Hormones; Analgesics; Aspirin; Child; Child, Preschool; Er | 1995 |
Drugs in the treatment of gastric and duodenal ulcer.
Topics: Amylopectin; Antacids; Bismuth; Carbenoxolone; Cholestyramine Resin; Duodenal Ulcer; Estrogens; Fatt | 1977 |
8 trials available for metoclopramide and Recrudescence
| Article | Year |
|---|---|
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diphenhydramine; Dopamine Antagonists; Double-Blind | 2013 |
Metoclopramide in the treatment of gastric bezoars.
Topics: Bezoars; Gastroscopy; Humans; Metoclopramide; Recurrence; Stomach | 1983 |
[Sumatriptan in the treatment of acute migraine: its role in primary health care].
Topics: Acute Disease; Administration, Oral; Algorithms; Aspirin; Caffeine; Double-Blind Method; Drug Therap | 1994 |
Evaluation of prochlorperazine buccal tablets (Bukatel) and metoclopramide oral tablets in the treatment of acute emesis.
Topics: Administration, Buccal; Administration, Oral; Adolescent; Adult; Aged; Antiemetics; Cholecystectomy; | 1999 |
[Therapy of gastric and duodenal ulcer with Metoclopramide].
Topics: Aged; Clinical Trials as Topic; Duodenal Ulcer; Female; Humans; Indomethacin; Male; Metoclopramide; | 1976 |
A study to compare oral sumatriptan with oral aspirin plus oral metoclopramide in the acute treatment of migraine. The Oral Sumatriptan and Aspirin plus Metoclopramide Comparative Study Group.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aspirin; Double-Blind Method; Drug Therapy, Combinati | 1992 |
Role of oxygen-derived free radical scavengers in the treatment of recurrent pain produced by chronic pancreatitis. A new approach.
Topics: Abdominal Pain; Adult; Aged; Alcoholism; Allopurinol; Chronic Disease; Dimethyl Sulfoxide; Double-Bl | 1991 |
Medical therapy for chronic reflux esophagitis. Long-term follow-up.
Topics: Barrett Esophagus; Chronic Disease; Cimetidine; Clinical Trials as Topic; Drug Therapy, Combination; | 1987 |
15 other studies available for metoclopramide and Recrudescence
| Article | Year |
|---|---|
Chest pain a manifestation of migraine.
Topics: Adult; Akathisia, Drug-Induced; Analgesics, Opioid; Chest Pain; Dopamine Antagonists; Electrocardiog | 2014 |
A comparison of acute treatment regimens for migraine in the emergency department.
Topics: Adolescent; Analgesics; Analgesics, Opioid; Child; Comparative Effectiveness Research; Diphenhydrami | 2015 |
Metoclopramide in the treatment of gastric bezoars.
Topics: Bezoars; Humans; Metoclopramide; Recurrence; Stomach | 1984 |
[Treatment of stomach ulcer (review)].
Topics: Aluminum; Antacids; Benzodiazepinones; Bismuth; Carbenoxolone; Cimetidine; Feeding Behavior; Gastrec | 1982 |
[Acetonemic vomiting. Treatment and prevention of recurrence].
Topics: Acetone; Child; Humans; Metoclopramide; Recurrence; Vomiting | 1980 |
[Stenosing hypertrophic antromyopathy].
Topics: Adult; Antiemetics; Cholecystectomy; Combined Modality Therapy; Female; Gallbladder Diseases; Humans | 1995 |
Suspected herbicide toxicosis in a dog.
Topics: 2-Methyl-4-chlorophenoxyacetic Acid; Abdominal Pain; Animals; Anorexia; Antidotes; Antiemetics; Atax | 1996 |
Gastroesophageal reflux and pulmonary complication in a neonate.
Topics: Antiemetics; Apnea; Cisapride; Follow-Up Studies; Gastroesophageal Reflux; Gastrointestinal Agents; | 1998 |
Multiple recurring gastric erosions/aphthous ulcers).
Topics: Adult; Antacids; Carbenoxolone; Endoscopy; Female; Humans; Male; Metoclopramide; Middle Aged; Recurr | 1976 |
[Gastric evacuatory function in peptic ulcer studied using radionuclide research data].
Topics: Adolescent; Adult; Atropine; Female; Gastric Emptying; Gastrointestinal Transit; Humans; Iodine Radi | 1989 |
Recurrent attacks of vomiting, hypertension and psychotic depression: a syndrome of periodic catecholamine and prostaglandin discharge.
Topics: Adolescent; Adrenocorticotropic Hormone; Arginine Vasopressin; Child, Preschool; Clonidine; Dinopros | 1988 |
[Repeated acute dystonia following administration of metoclopramide and fluphenazine].
Topics: Acute Disease; Adult; Dystonia; Female; Fluphenazine; Humans; Metoclopramide; Recurrence | 1988 |
Gastroesophageal reflux. pH probe-directed therapy.
Topics: Apnea; Barium Sulfate; Esophagogastric Junction; Esophagus; Female; Gastroesophageal Reflux; Humans; | 1986 |
Prolactin dynamics and tumour size in the prediction of surgical outcome for prolactinoma.
Topics: Female; Humans; Menstruation; Metoclopramide; Pituitary Function Tests; Pituitary Neoplasms; Postope | 1985 |
Triple tetracycline ('Deteclo') as a single dose oral treatment of uncomplicated gonorrhoea in the male.
Topics: Administration, Oral; Adolescent; Adult; Chlortetracycline; Demeclocycline; Diarrhea; Drug Combinati | 1973 |