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metoclopramide and Pernicious Vomiting of Pregnancy

metoclopramide has been researched along with Pernicious Vomiting of Pregnancy in 25 studies

Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.
metoclopramide : A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.

Research Excerpts

ExcerptRelevanceReference
"To compare ondansetron with metoclopramide in the treatment of hyperemesis gravidarum."9.19Ondansetron compared with metoclopramide for hyperemesis gravidarum: a randomized controlled trial. ( Abas, MN; Azmi, N; Omar, SZ; Tan, PC, 2014)
"To evaluate oral pyridoxine in conjunction with standard therapy in women hospitalized for hyperemesis gravidarum (HG)."9.14A placebo-controlled trial of oral pyridoxine in hyperemesis gravidarum. ( Omar, SZ; Tan, PC; Yow, CM, 2009)
"To compare the effects of promethazine with those of metoclopramide for hyperemesis gravidarum."9.14Promethazine compared with metoclopramide for hyperemesis gravidarum: a randomized controlled trial. ( Khine, PP; Omar, SZ; Tan, PC; Vallikkannu, N, 2010)
" The EMA-warning on metoclopramide in 2013 temporarily limited pre-hospital antiemetic provision associated with hospitalization at lower gestational length and indication of an increase in termination of pregnancy."8.12Antiemetic treatment of hyperemesis gravidarum in 1,064 Norwegian women and the impact of European warning on metoclopramide: a retrospective cohort study 2002-2019. ( Erdal, H; Heitmann, K; Holst, L; Trovik, J, 2022)
"The new protocol consisting of the combination of metoclopramide and diphenhydramine appears to be a good option in the management of hyperemesis gravidarum."7.75Metoclopramide and diphenhydramine in the treatment of hyperemesis gravidarum: effectiveness and predictors of rehospitalisation. ( Bérard, A; Ferreira, E; Lacasse, A; Lagoutte, A, 2009)
") metoclopramide in the outpatient treatment of hyperemesis gravidarum."7.70Home subcutaneous metoclopramide therapy for hyperemesis gravidarum. ( Bergauer, NK; Buttino, L; Coleman, SK; Gambon, C; Stanziano, GJ, 2000)
"To compare ondansetron with metoclopramide in the treatment of hyperemesis gravidarum."5.19Ondansetron compared with metoclopramide for hyperemesis gravidarum: a randomized controlled trial. ( Abas, MN; Azmi, N; Omar, SZ; Tan, PC, 2014)
"To evaluate oral pyridoxine in conjunction with standard therapy in women hospitalized for hyperemesis gravidarum (HG)."5.14A placebo-controlled trial of oral pyridoxine in hyperemesis gravidarum. ( Omar, SZ; Tan, PC; Yow, CM, 2009)
"To compare the effects of promethazine with those of metoclopramide for hyperemesis gravidarum."5.14Promethazine compared with metoclopramide for hyperemesis gravidarum: a randomized controlled trial. ( Khine, PP; Omar, SZ; Tan, PC; Vallikkannu, N, 2010)
"This study compares pyridoxine-metoclopramide combination therapy to prochlorperazine and promethazine monotherapies in the outpatient treatment of nausea and vomiting in pregnancy."5.10Comparison of three outpatient regimens in the management of nausea and vomiting in pregnancy. ( Bsat, FA; Hoffman, DE; Seubert, DE, 2003)
" The EMA-warning on metoclopramide in 2013 temporarily limited pre-hospital antiemetic provision associated with hospitalization at lower gestational length and indication of an increase in termination of pregnancy."4.12Antiemetic treatment of hyperemesis gravidarum in 1,064 Norwegian women and the impact of European warning on metoclopramide: a retrospective cohort study 2002-2019. ( Erdal, H; Heitmann, K; Holst, L; Trovik, J, 2022)
" For morning sickness, 89% of those replying give dietary advice frequently or always, and 70% prescribe metoclopramide frequently or always, whereas 59% advise pyridoxine and 10% prescribe doxylamine."3.79A survey of prescribing for the management of nausea and vomiting in pregnancy in Australasia. ( Raymond, SH, 2013)
"The new protocol consisting of the combination of metoclopramide and diphenhydramine appears to be a good option in the management of hyperemesis gravidarum."3.75Metoclopramide and diphenhydramine in the treatment of hyperemesis gravidarum: effectiveness and predictors of rehospitalisation. ( Bérard, A; Ferreira, E; Lacasse, A; Lagoutte, A, 2009)
") metoclopramide in the outpatient treatment of hyperemesis gravidarum."3.70Home subcutaneous metoclopramide therapy for hyperemesis gravidarum. ( Bergauer, NK; Buttino, L; Coleman, SK; Gambon, C; Stanziano, GJ, 2000)
"A 27-year-old, previously healthy normotensive woman was admitted for hyperemesis gravidarum and treated with intravenous fluids and metoclopramide."3.67Acute intermittent porphyria in pregnancy. ( Arlazoroff, A; Caspi, E; Klein, C; Milo, R; Neuman, M, 1989)
"Hyperemesis gravidarum is a severe form of nausea and vomiting in pregnancy affecting 0."2.53Interventions for treating hyperemesis gravidarum. ( Barton, SJ; Berghella, V; Boelig, RC; Edwards, SJ; Kelly, AJ; Saccone, G, 2016)
"Of note, co-existing gastroesophageal reflux disease (GERD), Helicobacter pylori infection, and psychosocial factors may have a negative impact on the management of NVP."2.50The outpatient management and special considerations of nausea and vomiting in pregnancy. ( Clark, SM; Dutta, E; Hankins, GD, 2014)
"Early pregnancy is characterized by nausea and vomiting which are the most frequent symptoms and the main reason for consulting the physician."2.41[Evaluation and treatment of hyperemesis gravidarum]. ( Accorsi, P; Aguzzoli, L; Carossino, E; Crotti, M; Gargano, G; Masellis, G, 2001)
"Metoclopramide also has an important place in the investigation of the role of dopamine in physiological and pathological processes."2.37Metoclopramide--a review. ( Desmond, PV; Watson, KJ, 1986)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19903 (12.00)18.7374
1990's1 (4.00)18.2507
2000's8 (32.00)29.6817
2010's12 (48.00)24.3611
2020's1 (4.00)2.80

Authors

AuthorsStudies
Erdal, H1
Holst, L2
Heitmann, K2
Trovik, J1
Tan, A1
Lowe, S1
Henry, A1
Havnen, GC1
Truong, MB1
Do, MH1
Nordeng, H1
Kashifard, M2
Basirat, Z1
Golsorkhtabar-Amiri, M1
Moghaddamnia, A1
Hastoy, A1
Lien Tran, P1
Lakestani, O1
Barau, G1
Gérardin, P1
Boukerrou, M1
Abas, MN1
Tan, PC3
Azmi, N1
Omar, SZ3
Clark, SM1
Dutta, E1
Hankins, GD1
Jarraya, A1
Elleuch, S1
Zouari, J1
Trigui, K1
Sofiene, A1
Smaoui, M1
Kolsi, K1
Festin, M1
Boelig, RC1
Barton, SJ1
Saccone, G1
Kelly, AJ1
Edwards, SJ1
Berghella, V1
Yow, CM1
Lacasse, A1
Lagoutte, A1
Ferreira, E1
Bérard, A1
Michel, ME1
Alanio, E1
Bois, E1
Gavillon, N1
Graesslin, O1
Khine, PP1
Vallikkannu, N1
Raymond, SH1
Bsat, FA1
Hoffman, DE1
Seubert, DE1
Neri, I1
Allais, G1
Schiapparelli, P1
Blasi, I1
Benedetto, C1
Facchinetti, F1
Buscaglia, J1
Faris, J1
Bondok, RS1
El Sharnouby, NM1
Eid, HE1
Abd Elmaksoud, AM1
Shenhav, S1
Gemer, O1
Sassoon, E1
Segal, S1
Buttino, L1
Coleman, SK1
Bergauer, NK1
Gambon, C1
Stanziano, GJ1
Crotti, M1
Aguzzoli, L1
Carossino, E1
Accorsi, P1
Gargano, G1
Masellis, G1
Askenasy, JJ1
Streifler, M1
Felner, S1
Milo, R1
Neuman, M1
Klein, C1
Caspi, E1
Arlazoroff, A1
Desmond, PV1
Watson, KJ1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Pilot, Randomized, Double-blind, Placebo-controlled Trial of Promethazine for Treatment of Diabetic Gastroparesis.[NCT02130622]Phase 23 participants (Actual)Interventional2014-07-31Terminated (stopped due to Lack of recruitment)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for metoclopramide and Pernicious Vomiting of Pregnancy

ArticleYear
The outpatient management and special considerations of nausea and vomiting in pregnancy.
    Seminars in perinatology, 2014, Volume: 38, Issue:8

    Topics: Ambulatory Care; Antiemetics; Diet Therapy; Doxylamine; Female; Fluid Therapy; Gastroesophageal Refl

2014
Interventions for treating hyperemesis gravidarum.
    The Cochrane database of systematic reviews, 2016, May-11, Issue:5

    Topics: Acupuncture Therapy; Adrenal Cortex Hormones; Antiemetics; Female; Humans; Hydrocortisone; Hyperemes

2016
[Evaluation and treatment of hyperemesis gravidarum].
    Minerva ginecologica, 2001, Volume: 53, Issue:6

    Topics: Administration, Oral; Adult; Antiemetics; Birth Weight; Chlorpromazine; Diagnosis, Differential; Fem

2001
Metoclopramide--a review.
    The Medical journal of Australia, 1986, Mar-31, Volume: 144, Issue:7

    Topics: Anxiety; Digestive System; Dopamine Antagonists; Drug Interactions; Female; Gastric Emptying; Gastro

1986

Trials

7 trials available for metoclopramide and Pernicious Vomiting of Pregnancy

ArticleYear
Ondansetrone or metoclopromide? Which is more effective in severe nausea and vomiting of pregnancy? A randomized trial double-blind study.
    Clinical and experimental obstetrics & gynecology, 2013, Volume: 40, Issue:1

    Topics: Adult; Antiemetics; Double-Blind Method; Female; Humans; Hyperemesis Gravidarum; Metoclopramide; Ond

2013
Ondansetron compared with metoclopramide for hyperemesis gravidarum: a randomized controlled trial.
    Obstetrics and gynecology, 2014, Volume: 123, Issue:6

    Topics: Adult; Antiemetics; Female; Humans; Hyperemesis Gravidarum; Metoclopramide; Ondansetron; Pregnancy;

2014
A placebo-controlled trial of oral pyridoxine in hyperemesis gravidarum.
    Gynecologic and obstetric investigation, 2009, Volume: 67, Issue:3

    Topics: Adult; Antiemetics; Drug Therapy, Combination; Female; Humans; Hyperemesis Gravidarum; Metoclopramid

2009
Promethazine compared with metoclopramide for hyperemesis gravidarum: a randomized controlled trial.
    Obstetrics and gynecology, 2010, Volume: 115, Issue:5

    Topics: Adult; Antiemetics; Double-Blind Method; Female; Humans; Hyperemesis Gravidarum; Metoclopramide; Pre

2010
Comparison of three outpatient regimens in the management of nausea and vomiting in pregnancy.
    Journal of perinatology : official journal of the California Perinatal Association, 2003, Volume: 23, Issue:7

    Topics: Adult; Antiemetics; Drug Therapy, Combination; Female; Humans; Hyperemesis Gravidarum; Metoclopramid

2003
Acupuncture versus pharmacological approach to reduce Hyperemesis gravidarum discomfort.
    Minerva ginecologica, 2005, Volume: 57, Issue:4

    Topics: Acupressure; Administration, Oral; Adult; Antiemetics; Chi-Square Distribution; Drug Therapy, Combin

2005
Pulsed steroid therapy is an effective treatment for intractable hyperemesis gravidarum.
    Critical care medicine, 2006, Volume: 34, Issue:11

    Topics: Adult; Anti-Inflammatory Agents; Antiemetics; Double-Blind Method; Female; Humans; Hydrocortisone; H

2006

Other Studies

14 other studies available for metoclopramide and Pernicious Vomiting of Pregnancy

ArticleYear
Antiemetic treatment of hyperemesis gravidarum in 1,064 Norwegian women and the impact of European warning on metoclopramide: a retrospective cohort study 2002-2019.
    BMC pregnancy and childbirth, 2022, Jun-02, Volume: 22, Issue:1

    Topics: Antiemetics; Female; Humans; Hyperemesis Gravidarum; Metoclopramide; Pregnancy; Quality of Life; Ret

2022
Nausea and vomiting of pregnancy: Effects on quality of life and day-to-day function.
    The Australian & New Zealand journal of obstetrics & gynaecology, 2018, Volume: 58, Issue:3

    Topics: Activities of Daily Living; Antiemetics; Cohort Studies; Female; Humans; Hyperemesis Gravidarum; Met

2018
Women's perspectives on the management and consequences of hyperemesis gravidarum - a descriptive interview study.
    Scandinavian journal of primary health care, 2019, Volume: 37, Issue:1

    Topics: Abortion, Induced; Activities of Daily Living; Adult; Antiemetics; Attitude; Cross-Sectional Studies

2019
[Hyperemesis gravidarum and pregnancy outcomes].
    Journal de gynecologie, obstetrique et biologie de la reproduction, 2015, Volume: 44, Issue:2

    Topics: Adult; Antiemetics; Female; Hospitalization; Humans; Hyperemesis Gravidarum; Infant, Newborn; Metocl

2015
[Hyperemesis gravidarum with severe electrolyte disorders: report of a case].
    The Pan African medical journal, 2015, Volume: 20

    Topics: Acute Kidney Injury; Antiemetics; Female; Fluid Therapy; Hepatomegaly; Humans; Hyperemesis Gravidaru

2015
Nausea and Vomiting in Early Pregnancy.
    American family physician, 2015, Sep-15, Volume: 92, Issue:6

    Topics: Acupuncture; Antiemetics; Female; Humans; Hydrocortisone; Hyperemesis Gravidarum; Metoclopramide; Mo

2015
Metoclopramide and diphenhydramine in the treatment of hyperemesis gravidarum: effectiveness and predictors of rehospitalisation.
    European journal of obstetrics, gynecology, and reproductive biology, 2009, Volume: 143, Issue:1

    Topics: Adolescent; Adult; Antiemetics; Cohort Studies; Diphenhydramine; Drug Therapy, Combination; Female;

2009
Wernicke encephalopathy complicating hyperemesis gravidarum: a case report.
    European journal of obstetrics, gynecology, and reproductive biology, 2010, Volume: 149, Issue:1

    Topics: Adult; Drug Therapy, Combination; Female; Humans; Hyperemesis Gravidarum; Metoclopramide; Niacinamid

2010
A survey of prescribing for the management of nausea and vomiting in pregnancy in Australasia.
    The Australian & New Zealand journal of obstetrics & gynaecology, 2013, Volume: 53, Issue:4

    Topics: Antiemetics; Australia; Dopamine Antagonists; Female; Histamine Antagonists; Humans; Hyperemesis Gra

2013
Unsteady, unfocused, and unable to hear.
    The American journal of medicine, 2005, Volume: 118, Issue:11

    Topics: Adolescent; Cognition Disorders; Combined Modality Therapy; Female; Fluid Therapy; Gait Disorders, N

2005
Acute intermittent porphyria precipitated by hyperemesis and metoclopramide treatment in pregnancy.
    Acta obstetricia et gynecologica Scandinavica, 1997, Volume: 76, Issue:5

    Topics: Adult; Antiemetics; Female; Glucose Solution, Hypertonic; Hemin; Humans; Hyperemesis Gravidarum; Met

1997
Home subcutaneous metoclopramide therapy for hyperemesis gravidarum.
    Journal of perinatology : official journal of the California Perinatal Association, 2000, Volume: 20, Issue:6

    Topics: Adult; Antiemetics; Female; Home Care Services; Humans; Hyperemesis Gravidarum; Infusion Pumps; Inje

2000
The synaptic significance of metoclopramide induced dyskinetic-dystonic head and neck movements in pregnancy.
    Journal of neural transmission, 1978, Volume: 42, Issue:1

    Topics: Adolescent; Adult; Dyskinesia, Drug-Induced; Female; Head; Humans; Hyperemesis Gravidarum; Metoclopr

1978
Acute intermittent porphyria in pregnancy.
    Obstetrics and gynecology, 1989, Volume: 73, Issue:3 Pt 2

    Topics: Acute Disease; Adult; Diagnosis, Differential; Female; Fluid Therapy; Genes, Dominant; Humans; Hyper

1989