metoclopramide has been researched along with Parkinson Disease in 22 studies
Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.
metoclopramide : A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A case of prolonged encephalopathy and worsened parkinsonism in a Parkinson disease patient exposed to a short course of metoclopramide is described." | 7.76 | Metoclopramide-induced encephalopathy in Parkinson disease. ( Anderson, KE; Robottom, BJ; Shulman, LM; Weiner, WJ, 2010) |
| " Although known to interfere with central dopamine mechanisms, it is frequently used in Parkinson's disease to prevent levodopa-induced nausea and vomiting." | 5.04 | Metoclopramide and pimozide in Parkinson's disease and levodopa-induced dyskinesias. ( Marsden, CD; Parkes, JD; Tarsy, D, 1975) |
| "A case of prolonged encephalopathy and worsened parkinsonism in a Parkinson disease patient exposed to a short course of metoclopramide is described." | 3.76 | Metoclopramide-induced encephalopathy in Parkinson disease. ( Anderson, KE; Robottom, BJ; Shulman, LM; Weiner, WJ, 2010) |
| "5." | 2.64 | Plasma bromocriptine levels, clinical and growth hormone responses in Parkinsonism. ( Debono, A; Marsden, CD; Parkes, JD; Price, P; Rosenthaler, J, 1978) |
| "The case of a patient with Parkinson's disease (PD) who experienced profound encephalopathy after short-term exposure to metoclopramide is described." | 1.38 | Encephalopathy associated with metoclopramide use in a patient with Parkinson's disease. ( Johnson, BR; Khan, MA; Messerschmidt, KA, 2012) |
| "Metoclopramide 60 mg oral was given 30 minutes before bromocriptine or levodopa to establish whether this caused dopamine-receptor blockade." | 1.26 | Bromocriptine in Parkinsonism: long-term treatment, dose response, and comparison with levodopa. ( Debono, AG; Marsden, CD; Parkes, JD, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (81.82) | 18.7374 |
| 1990's | 2 (9.09) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Robottom, BJ | 1 |
| Shulman, LM | 1 |
| Anderson, KE | 1 |
| Weiner, WJ | 1 |
| Messerschmidt, KA | 1 |
| Johnson, BR | 1 |
| Khan, MA | 1 |
| Campbell, DJ | 1 |
| Mendelsohn, FA | 1 |
| Adam, WR | 1 |
| Funder, JW | 1 |
| Schachter, M | 1 |
| Bédard, P | 1 |
| Debono, AG | 2 |
| Jenner, P | 3 |
| Marsden, CD | 7 |
| Price, P | 2 |
| Parkes, JD | 5 |
| Keenan, J | 1 |
| Smith, B | 1 |
| Rosenthaler, J | 2 |
| Horowski, R | 1 |
| Dorow, R | 1 |
| Mateos, V | 1 |
| Caminal, L | 1 |
| Colosía, VP | 1 |
| Campos, DM | 1 |
| Negoro, K | 1 |
| Morimatsu, M | 1 |
| Nogaki, H | 1 |
| Tarsy, D | 3 |
| Peringer, E | 1 |
| Bateman, DN | 1 |
| Kahn, C | 1 |
| Legg, NJ | 1 |
| Reid, JL | 1 |
| Debono, A | 1 |
| Rampton, DS | 1 |
| Dolphin, A | 1 |
| Pycock, C | 1 |
| Holmsen, R | 1 |
| Corsini, GU | 1 |
| Zompo, MD | 1 |
| Cianchetti, C | 1 |
| Mangoni, A | 1 |
| Laihinen, A | 1 |
| Rinne, UK | 1 |
| Shaughnessy, AF | 1 |
| Carter, AB | 1 |
| Mearrick, PT | 1 |
| Wade, DN | 1 |
| Birkett, DJ | 1 |
| Morris, J | 1 |
2 reviews available for metoclopramide and Parkinson Disease
| Article | Year |
|---|---|
Is aldosterone secretion under dopaminergic control?
Topics: Aldosterone; Bromocriptine; Chlorpromazine; Dopamine; Dopamine Antagonists; Edema; Humans; Levodopa; | 1981 |
Potential uses for metoclopramide.
Topics: Anorexia Nervosa; Bezoars; Dyskinesia, Drug-Induced; Failure to Thrive; Hiccup; Humans; Metocloprami | 1985 |
4 trials available for metoclopramide and Parkinson Disease
| Article | Year |
|---|---|
Letter: Metoclopramide in parkinsonism.
Topics: Clinical Trials as Topic; Humans; Levodopa; Metoclopramide; Nausea; Parkinson Disease; Promethazine; | 1975 |
Metoclopramide in Parkinson's disease.
Topics: Aged; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Humans; Metoclopramide; Middle | 1978 |
Plasma bromocriptine levels, clinical and growth hormone responses in Parkinsonism.
Topics: Aged; Blood Pressure; Bromocriptine; Clinical Trials as Topic; Female; Growth Hormone; Humans; Male; | 1978 |
Metoclopramide and pimozide in Parkinson's disease and levodopa-induced dyskinesias.
Topics: Aged; Carbidopa; Clinical Trials as Topic; Drug Evaluation; Drug Interactions; Drug Therapy, Combina | 1975 |
16 other studies available for metoclopramide and Parkinson Disease
| Article | Year |
|---|---|
Metoclopramide-induced encephalopathy in Parkinson disease.
Topics: Aged; Antiemetics; Constipation; Humans; Male; Metoclopramide; Neurotoxicity Syndromes; Parkinson Di | 2010 |
Encephalopathy associated with metoclopramide use in a patient with Parkinson's disease.
Topics: Aged; Brain Diseases, Metabolic; Humans; Male; Metoclopramide; Parkinson Disease | 2012 |
Not Parkinson's disease.
Topics: Adult; Aged; Antipsychotic Agents; Diagnosis, Differential; Humans; Metoclopramide; Middle Aged; Par | 1982 |
The role of D-1 and D-2 receptors.
Topics: Adenylyl Cyclases; Bromocriptine; Growth Hormone; Humans; Levodopa; Lisuride; Metoclopramide; Parkin | 1980 |
[Parkinsonism induced by metoclopramide].
Topics: Female; Humans; Metoclopramide; Middle Aged; Parkinson Disease | 1993 |
Drug-induced dystonia and dysphonia in Parkinson's disease.
Topics: Dopamine Antagonists; Dystonia; Humans; Metoclopramide; Parkinson Disease; Voice Disorders | 1999 |
Effect of metoclopramide on turnover of brain dopamine noradrenaline and 5-hydroxytryptamine.
Topics: Animals; Brain; Brain Chemistry; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Homova | 1975 |
Hypertensive crisis in a patient given sinemet, metoclopramide, and amitriptyline.
Topics: Acute Disease; Amitriptyline; Carbidopa; Drug Combinations; Drug Therapy, Combination; Female; Human | 1977 |
Bromocriptine in Parkinsonism: long-term treatment, dose response, and comparison with levodopa.
Topics: Aged; Bromocriptine; Dose-Response Relationship, Drug; Drug Evaluation; Drug Therapy, Combination; D | 1976 |
Pharmacological evidence for cerebral dopamine receptor blockade by metoclopramide in rodents.
Topics: Animals; Apomorphine; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Humans; Male; Met | 1975 |
[L-dopa-decarboxylase inhibitor combination preparation (Sinemet) in parkinsonism and syndromes imitating parkinsonism. 1 year's experience with 34 patients].
Topics: Aged; Drug Combinations; Female; Humans; Levodopa; Male; Metoclopramide; Middle Aged; Nausea; Parkin | 1976 |
Therapeutical efficacy of a combination of apomorphine with sulpiride or metoclopramide in Parkinsonism.
Topics: Adult; Apomorphine; Drug Therapy, Combination; Haloperidol; Humans; Male; Metoclopramide; Parkinson | 1976 |
Dopamine receptor function in Parkinson's disease--in vivo studies with prolactin responses.
Topics: Bromocriptine; Corpus Striatum; Humans; Metoclopramide; Parkinson Disease; Prolactin; Receptors, Dop | 1987 |
Letter: Pyridoxine contraindicated in parkinsonism.
Topics: Dihydroxyphenylalanine; Drug Antagonism; Humans; Metoclopramide; Nausea; Parkinson Disease; Pyridoxi | 1973 |
Letter: Pyridoxine in parkinsonism.
Topics: Dihydroxyphenylalanine; Drug Antagonism; Drug Interactions; Humans; Metoclopramide; Movement Disorde | 1973 |
Metoclopramide, gastric emptying and L-dopa absorption.
Topics: Biological Transport, Active; Biopharmaceutics; Female; Fluorometry; Gastrointestinal Motility; Huma | 1974 |