Compounds > metoclopramide
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metoclopramide and Parkinson Disease, Secondary

metoclopramide has been researched along with Parkinson Disease, Secondary in 44 studies

Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.
metoclopramide : A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.

Parkinson Disease, Secondary: Conditions which feature clinical manifestations resembling primary Parkinson disease that are caused by a known or suspected condition. Examples include parkinsonism caused by vascular injury, drugs, trauma, toxin exposure, neoplasms, infections and degenerative or hereditary conditions. Clinical features may include bradykinesia, rigidity, parkinsonian gait, and masked facies. In general, tremor is less prominent in secondary parkinsonism than in the primary form. (From Joynt, Clinical Neurology, 1998, Ch38, pp39-42)

Research Excerpts

ExcerptRelevanceReference
"A case of prolonged encephalopathy and worsened parkinsonism in a Parkinson disease patient exposed to a short course of metoclopramide is described."7.76Metoclopramide-induced encephalopathy in Parkinson disease. ( Anderson, KE; Robottom, BJ; Shulman, LM; Weiner, WJ, 2010)
"A 46-year-old female patient with metoclopramide-induced parkinsonism and depression was reported in view of the rarity of the concurrent development of these side effects."7.68Metoclopramide-induced parkinsonism and depression. ( Jibiki, I; Maeda, T; Yamaguchi, N, 1992)
" Although known to interfere with central dopamine mechanisms, it is frequently used in Parkinson's disease to prevent levodopa-induced nausea and vomiting."5.04Metoclopramide and pimozide in Parkinson's disease and levodopa-induced dyskinesias. ( Marsden, CD; Parkes, JD; Tarsy, D, 1975)
"A case of prolonged encephalopathy and worsened parkinsonism in a Parkinson disease patient exposed to a short course of metoclopramide is described."3.76Metoclopramide-induced encephalopathy in Parkinson disease. ( Anderson, KE; Robottom, BJ; Shulman, LM; Weiner, WJ, 2010)
" Metoclopramide-treated patients had significantly greater severity of tardive dyskinesia, drug-induced parkinsonism, and subjective akathisia than controls."3.68The prevalence of metoclopramide-induced tardive dyskinesia and acute extrapyramidal movement disorders. ( Casey, DE; Ganzini, L; Hoffman, WF; McCall, AL, 1993)
"A 46-year-old female patient with metoclopramide-induced parkinsonism and depression was reported in view of the rarity of the concurrent development of these side effects."3.68Metoclopramide-induced parkinsonism and depression. ( Jibiki, I; Maeda, T; Yamaguchi, N, 1992)
" To prevent persistent and disabling movement disorders, long-term use of metoclopramide should be avoided, and patients should be carefully observed for potential neurologic reactions."2.38Metoclopramide-induced movement disorders. Clinical findings with a review of the literature. ( Jankovic, J; Miller, LG, 1989)
"The nausea was treated with metoclopramide."1.31[Severe parkinsonism due to metoclopramide in a patient with polypharmacy]. ( Frijns, CJ; Heeringa, M; Hofmeijer, J; Hoogendam, A; Jansen, PA; Schouten-Tjin a Tsoi, SL, 2002)
"Metoclopramide users were three times more likely to begin use of a levodopa-containing medication compared with nonusers (OR = 3."1.29Increased incidence of levodopa therapy following metoclopramide use. ( Avorn, J; Bohn, RL; Gurwitz, JH; Mogun, H; Monane, M; Walker, A, 1995)
"Metoclopramide hydrochloride is an antiemetic and gastric motility stimulant with a wide variety of extrapyramidal side effects, including parkinsonism."1.27Metoclopramide-induced parkinsonism in hemodialysis patients. Report of two cases. ( Diamond, BF; Kimmel, PL; Sirota, RA; Stein, HD; Trichtinger, MD; Yudis, M, 1986)
"The overall reporting rate for dystonia and dyskinesia was 28."1.27Extrapyramidal reactions with metoclopramide. ( Bateman, DN; Rawlins, MD; Simpson, JM, 1985)
"Metoclopramide is known to produce three froms of extrapyramidal and motor side effects, namely: 1."1.26[Extrapyramidal syndromes as side-effects of metoclopramide (Cerucal) medication]. ( Decke, D; Felber, W; Kunath, B; Papperitz, V, 1976)

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-199029 (65.91)18.7374
1990's8 (18.18)18.2507
2000's4 (9.09)29.6817
2010's3 (6.82)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
de Ronde, MW1
Kingma, HJ1
Munts, AG1
Robottom, BJ1
Shulman, LM1
Anderson, KE1
Weiner, WJ1
Levin, OS1
Shindriaeva, NN1
Anikina, MA1
Habets, P1
Johnson, CD2
Shynett, B1
Maldonado, BJ1
Bitton, V1
Melamed, E1
Prusiński, A1
Ahmad, S1
Grimes, JD3
Magner, PO1
Sandyk, R1
Buchholz, D1
Kariya, S1
Hassan, MN1
Preston, DN1
Indo, T1
Ando, K1
Leupold, H1
Avorn, J1
Gurwitz, JH1
Bohn, RL1
Mogun, H1
Monane, M1
Walker, A1
Ganzini, L1
Casey, DE1
Hoffman, WF1
McCall, AL1
Hoogendam, A1
Hofmeijer, J1
Frijns, CJ1
Heeringa, M1
Schouten-Tjin a Tsoi, SL1
Jansen, PA1
Kataria, M1
Traub, M1
Marsden, CD2
Granérus, AK1
Felber, W1
Kunath, B1
Papperitz, V1
Decke, D1
Tarsy, D1
Parkes, JD1
Jibiki, I1
Maeda, T1
Yamaguchi, N1
Lauterbach, EC1
Rodgers, C1
Sethi, KD2
Zamrini, EY1
Jenkins, M1
Metzer, WS1
Yamamoto, M2
Ujike, H1
Ogawa, N2
Bateman, DN2
Darling, WM1
Boys, R1
Rawlins, MD2
Patel, B1
Meador, KJ1
Maricle, RA1
Leung, P1
Miller, LG1
Jankovic, J1
Sun, B1
Cao, QL1
Ou, XR1
Patel, M1
Louis, S1
Uchiyama, F1
Kamei, T1
Fukuyama, J1
Akashi, T1
Ohta, H1
Sirota, RA1
Kimmel, PL1
Trichtinger, MD1
Diamond, BF1
Stein, HD1
Yudis, M1
Takayama, H1
Kuroda, H1
Ota, Z1
Simpson, JM1
Chouza, C1
Caamano, JL1
Romero, S1
Lorenzo, J1
Feres, S1
Markman, M1
Newman, DR1
Hawkins, RS1

Reviews

1 review available for metoclopramide and Parkinson Disease, Secondary

ArticleYear
Metoclopramide-induced movement disorders. Clinical findings with a review of the literature.
    Archives of internal medicine, 1989, Volume: 149, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Basal Ganglia Diseases; Dyskinesia, Drug-Induced; Female; Humans; Ma

1989

Trials

2 trials available for metoclopramide and Parkinson Disease, Secondary

ArticleYear
Metoclopramide and pimozide in Parkinson's disease and levodopa-induced dyskinesias.
    Journal of neurology, neurosurgery, and psychiatry, 1975, Volume: 38, Issue:4

    Topics: Aged; Carbidopa; Clinical Trials as Topic; Drug Evaluation; Drug Interactions; Drug Therapy, Combina

1975
Metoclopramide (Reglan) for gastroesophageal reflux.
    The Medical letter on drugs and therapeutics, 1985, Mar-01, Volume: 27, Issue:682

    Topics: Adult; Clinical Trials as Topic; Dyskinesia, Drug-Induced; Gastroesophageal Reflux; Humans; Metoclop

1985

Other Studies

41 other studies available for metoclopramide and Parkinson Disease, Secondary

ArticleYear
[Severe parkinsonism due to metoclopramide: the importance of early recognition].
    Nederlands tijdschrift voor geneeskunde, 2013, Volume: 157, Issue:26

    Topics: Aged; Aged, 80 and over; Antiemetics; Female; Humans; Metoclopramide; Parkinson Disease, Secondary

2013
Metoclopramide-induced encephalopathy in Parkinson disease.
    Southern medical journal, 2010, Volume: 103, Issue:2

    Topics: Aged; Antiemetics; Constipation; Humans; Male; Metoclopramide; Neurotoxicity Syndromes; Parkinson Di

2010
[Drug-induced parkinsonism].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2012, Volume: 112, Issue:8

    Topics: Anticonvulsants; Antipsychotic Agents; Calcium Channel Blockers; Cinnarizine; Diagnosis, Differentia

2012
[Severe parkinsonism due to metoclopramide in a patient with polypharmacy].
    Nederlands tijdschrift voor geneeskunde, 2002, Jul-27, Volume: 146, Issue:30

    Topics: Child; Dopamine Antagonists; Humans; Infant; Metoclopramide; Parkinson Disease, Secondary; Polypharm

2002
Extrapyramidal reactions to SSRI antidepressant + neuroleptic combinations.
    Prescrire international, 2004, Volume: 13, Issue:70

    Topics: Antidepressive Agents; Antipsychotic Agents; Basal Ganglia Diseases; Drug Interactions; Drug Therapy

2004
Rapid onset of Parkinsonian-like symptoms in a geriatric dental patient: a case report.
    Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), 2006, Volume: 27, Issue:11

    Topics: Aged, 80 and over; Bupropion; Dopamine Antagonists; Dopamine Uptake Inhibitors; Health Status; Human

2006
Not Parkinson's disease.
    Lancet (London, England), 1982, Jul-03, Volume: 2, Issue:8288

    Topics: Adult; Aged; Antipsychotic Agents; Diagnosis, Differential; Humans; Metoclopramide; Middle Aged; Par

1982
Coexistence of severe parkinsonism and tardive dyskinesia as side effects of neuroleptic therapy.
    The Journal of clinical psychiatry, 1984, Volume: 45, Issue:1

    Topics: Aged; Antipsychotic Agents; Carbidopa; Corpus Striatum; Depressive Disorder; Drug Combinations; Dysk

1984
[Oculogyric crises as a side effect of metoclopramide].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 1984, Mar-01, Volume: 37, Issue:5

    Topics: Eye Movements; Female; Humans; Metoclopramide; Middle Aged; Parkinson Disease, Secondary; Peptic Ulc

1984
Metoclopramide-induced parkinsonism and severe edema.
    Southern medical journal, 1984, Volume: 77, Issue:10

    Topics: Acute Disease; Edema; Humans; Male; Metoclopramide; Middle Aged; Parkinson Disease, Secondary

1984
Safety of domperidone in metoclopramide-induced parkinsonism.
    Archives of neurology, 1984, Volume: 41, Issue:4

    Topics: Domperidone; Female; Humans; Metoclopramide; Middle Aged; Parkinson Disease, Secondary

1984
Metoclopramide-induced parkinsonism.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1983, May-28, Volume: 63, Issue:22

    Topics: Humans; Male; Metoclopramide; Middle Aged; Parkinson Disease, Secondary

1983
Metoclopramide-induced Parkinsonism.
    Archives of neurology, 1983, Volume: 40, Issue:8

    Topics: Adult; Female; Humans; Metoclopramide; Parkinson Disease, Secondary

1983
Adverse neurologic effects of metoclopramide.
    Canadian Medical Association journal, 1982, Jan-01, Volume: 126, Issue:1

    Topics: Aged; Dyskinesia, Drug-Induced; Dystonia; Female; Humans; Male; Metoclopramide; Middle Aged; Parkins

1982
Metoclopramide-induced Parkinsonism. Clinical characteristics of ten cases.
    Archives of neurology, 1982, Volume: 39, Issue:8

    Topics: Aged; Female; Gastrointestinal Diseases; Humans; Metoclopramide; Parkinson Disease, Secondary; Tremo

1982
Parkinsonism and tardive dyskinesia associated with long-term metoclopramide therapy.
    The New England journal of medicine, 1981, Dec-03, Volume: 305, Issue:23

    Topics: Aged; Dyskinesia, Drug-Induced; Humans; Metoclopramide; Parkinson Disease, Secondary; Time Factors

1981
[Cerebral side effects in metoclopramide (Cerucal) administration].
    Zeitschrift fur arztliche Fortbildung, 1981, Nov-01, Volume: 75, Issue:21

    Topics: Adolescent; Antiparkinson Agents; Dyskinesia, Drug-Induced; Female; Humans; Metoclopramide; Parkinso

1981
Increased incidence of levodopa therapy following metoclopramide use.
    JAMA, 1995, Dec-13, Volume: 274, Issue:22

    Topics: Aged; Case-Control Studies; Female; Humans; Levodopa; Male; Metoclopramide; Parkinson Disease, Secon

1995
The prevalence of metoclopramide-induced tardive dyskinesia and acute extrapyramidal movement disorders.
    Archives of internal medicine, 1993, Jun-28, Volume: 153, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Akathisia, Drug-Induced; Basal Ganglia Diseases; Diabetes Complicati

1993
Parkinsonism: an under-recognised complication of metoclopramide use.
    The Ceylon medical journal, 1996, Volume: 41, Issue:3

    Topics: Age Factors; Aged; Dopamine Antagonists; Humans; Metoclopramide; Parkinson Disease, Secondary

1996
[Severe parkinsonism due to metoclopramide in a patient with polypharmacy].
    Nederlands tijdschrift voor geneeskunde, 2002, Jan-26, Volume: 146, Issue:4

    Topics: Aged; Antiemetics; Antitubercular Agents; Dopamine Antagonists; Dose-Response Relationship, Drug; Fe

2002
Extrapyramidal side-effects of metoclopramide.
    Lancet (London, England), 1978, Dec-09, Volume: 2, Issue:8102

    Topics: Aged; Dyskinesia, Drug-Induced; Female; Humans; Metoclopramide; Parkinson Disease, Secondary; Time F

1978
Factors influencing the occurrence of "on-off" symptoms during long-term treatment with L-dopa.
    Acta medica Scandinavica, 1978, Volume: 203, Issue:1-2

    Topics: Adult; Aged; Drug Evaluation; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Follow-Up Studies

1978
[Extrapyramidal syndromes as side-effects of metoclopramide (Cerucal) medication].
    Psychiatrie, Neurologie, und medizinische Psychologie, 1976, Volume: 28, Issue:12

    Topics: Adult; Aged; Basal Ganglia Diseases; Dyskinesia, Drug-Induced; Female; Humans; Hyperkinesis; Male; M

1976
Metoclopramide-induced parkinsonism and depression.
    Acta neurologica, 1992, Volume: 14, Issue:2

    Topics: Depression; Female; Humans; Metoclopramide; Middle Aged; Parkinson Disease, Secondary

1992
Haloperidol-induced dystonia and parkinsonism on discontinuing metoclopramide: implications for differential thalamocortical activity.
    Journal of clinical psychopharmacology, 1992, Volume: 12, Issue:6

    Topics: Adult; Brain; Drug Therapy, Combination; Dystonia; Female; Haloperidol; Humans; Metoclopramide; Park

1992
Extrapyramidal side effects of antiemetics presenting as psychiatric illness.
    General hospital psychiatry, 1992, Volume: 14, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Akathisia, Drug-Induced; Antiemetics; Anxiety Disor

1992
Asymmetry in clinical features of drug-induced parkinsonism.
    The Journal of neuropsychiatry and clinical neurosciences, 1990,Winter, Volume: 2, Issue:1

    Topics: Adult; Aged; Antipsychotic Agents; Basal Ganglia Diseases; Dominance, Cerebral; Female; Humans; Male

1990
Avoidance of metoclopramide for the treatment of clozapine-induced nausea.
    The Journal of clinical psychiatry, 1990, Volume: 51, Issue:5

    Topics: Clozapine; Dibenzazepines; Dyskinesia, Drug-Induced; Humans; Metoclopramide; Nausea; Parkinson Disea

1990
Metoclopramide-induced parkinsonism.
    Clinical neuropharmacology, 1987, Volume: 10, Issue:3

    Topics: Aged; Aged, 80 and over; Anorexia; Gastritis; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; M

1987
Extrapyramidal reactions to metoclopramide and prochlorperazine.
    The Quarterly journal of medicine, 1989, Volume: 71, Issue:264

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Akathisia, Drug-Induced; Basal Ganglia Diseases; Child;

1989
Metoclopramide-induced parkinsonism.
    Southern medical journal, 1989, Volume: 82, Issue:12

    Topics: Adult; Aged; Female; Follow-Up Studies; Humans; Kidney Failure, Chronic; Male; Metoclopramide; Middl

1989
Metoclopramide-associated parkinsonism mimicking functional psychiatric illness.
    The American journal of gastroenterology, 1989, Volume: 84, Issue:12

    Topics: Aged; Diagnosis, Differential; Female; Humans; Metoclopramide; Parkinson Disease, Secondary; Substan

1989
[Adverse neurologic effects of metoclopramide. Report of 60 cases].
    Zhonghua nei ke za zhi, 1988, Volume: 27, Issue:6

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Dyskinesia, Drug-Induced; Dystonia; Female; Humans

1988
Long-term neurologic complications of metoclopramide.
    New York state journal of medicine, 1986, Volume: 86, Issue:4

    Topics: Aged; Dyskinesia, Drug-Induced; Female; Humans; Metoclopramide; Parkinson Disease, Secondary; Substa

1986
[Four cases of metoclopramide-induced parkinsonism].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1986, Volume: 75, Issue:4

    Topics: Age Factors; Aged; Female; Humans; Metoclopramide; Middle Aged; Parkinson Disease, Secondary; Progno

1986
Metoclopramide-induced parkinsonism in hemodialysis patients. Report of two cases.
    Archives of internal medicine, 1986, Volume: 146, Issue:10

    Topics: Adult; Aged; Diabetic Nephropathies; Female; Humans; Kidney Failure, Chronic; Male; Metoclopramide;

1986
[Incidence of parkinsonism after treatment with metoclopramide].
    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 1986, Volume: 23, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Male; Metoclopramide; Middle Aged; Parkinson Disease

1986
Extrapyramidal reactions with metoclopramide.
    British medical journal (Clinical research ed.), 1985, Oct-05, Volume: 291, Issue:6500

    Topics: Adolescent; Adult; Age Factors; Aged; Child; Child, Preschool; Dystonia; Female; Humans; Infant; Inf

1985
Extrapyramidal effects of benzamides.
    Advances in biochemical psychopharmacology, 1985, Volume: 40

    Topics: Basal Ganglia Diseases; Benzamides; Dyskinesia, Drug-Induced; Humans; Metoclopramide; Movement Disor

1985
Parkinsonism following i.v. administration of high-dose metoclopramide used as an antiemetic agent during cancer chemotherapy.
    Cancer treatment reports, 1985, Volume: 69, Issue:3

    Topics: Abdominal Neoplasms; Adenocarcinoma; Aged; Cisplatin; Female; Humans; Metoclopramide; Nausea; Ovaria

1985