metoclopramide has been researched along with Pain in 54 studies
Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.
metoclopramide : A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The incidence of pain upon injection of propofol-lipuro is low in comparison with incidence rates reported in the literature for the traditional formula, but administration of the fat emulsion formula through a vein on the dorsal side of the hand or through a venous catheter smaller than 18 G should be avoided." | 10.21 | [Incidence of pain upon injection of a new formula of propofol in a fat emulsion of medium- and long-chain triglycerides]. ( Ayuso, MA; Fernández, J; Gomar, C; Luis, M; Sala, X, 2004) |
| "Propofol injection is known to cause distressing pain, and various methods have been used to decrease this pain." | 9.17 | A prospective, randomized, double-blind study to compare the efficacy of lidocaine + metoclopramide and lidocaine + ketamine combinations in preventing pain on propofol injection. ( Chaudhary, K; Gogia, AR; Gupta, P, 2013) |
| "Lidocaine and metoclopramide were equally and the most effective treatments in attenuating pain during intravenous injection of propofol compared to pretreatment with remifentanil and ketamine." | 9.16 | The effects of remifentanil, lidocaine, metoclopramide, or ketamine pretreatment on propofol injection pain. ( Aktay, M; Ozlü, O; Polat, R, 2012) |
| "The aim of this study was to compare the efficacy of lidocaine, metoclopramide, and flurbiprofen axetil for reducing pain on injection of propofol in Japanese adult surgical patients." | 9.13 | Comparison of lidocaine, metoclopramide, and flurbiprofen axetil for reducing pain on injection of propofol in Japanese adult surgical patients: a prospective, randomized, double-blind, parallel-group, placebo-controlled study. ( Fujii, Y; Itakura, M, 2008) |
| "Among these 240 Japanese patients undergoing elective surgery, N administration of LID/MET 40/5 or 40/10 was associated with lower incidence, but not lower mean pain intensity scores, of pain on injection of propofol than LID/MET 40/2." | 9.12 | Prevention of pain due to injection of propofol with IV administration of lidocaine 40 mg + metoclopramide 2.5, 5, or 10 mg or saline: a randomized, double-blind study in Japanese adult surgical patients. ( Fujii, Y; Nakayama, M, 2007) |
| "Pain on injection is still a major problem with propofol; metoclopramide effectively decreases this pain." | 9.12 | Age-related differences in metoclopramide requirement for pain on injection of propofol. ( Fujii, Y; Shiga, Y, 2006) |
| "A randomised controlled trial was carried out on patients requiring morphine for acute pain in the emergency department (ED) setting." | 9.12 | Use of a prophylactic antiemetic with morphine in acute pain: randomised controlled trial. ( Bradshaw, M; Sen, A, 2006) |
| "5 mg, 5 mg, 10 mg) for reducing pain on injection of propofol in 100 patients scheduled for elective surgery." | 9.11 | Effect of metoclopramide on pain on injection of propofol. ( Fujii, Y; Uemura, A, 2004) |
| "25 patients (83%) complained of pain in the placebo group, compared with 12 (40%) in the lidocaine group (P < 0." | 9.11 | A lidocaine/metoclopramide combination decreases pain on injection of propofol. ( Fujii, Y; Nakayama, M, 2005) |
| "Aim of this study was to demonstrate that intravenous metoclopramide can reduce pain, nausea and discomfort during nasogastric tube (NGT) insertion in ED." | 9.11 | Effectiveness of pre-emptive metoclopramide infusion in alleviating pain, discomfort and nausea associated with nasogastric tube insertion: a randomised, double-blind, placebo-controlled trial. ( Karaca, MA; Ozucelik, DN; Sivri, B, 2005) |
| "Metoclopramide, rather than lidocaine pretreatment, may be a reasonable analgesic alternative to decrease pain from a diazepam injection, especially when there is a medical condition in which lidocaine should be used very cautiously." | 9.10 | A comparison of metoclopramide and lidocaine for preventing pain on injection of diazepam. ( Hassannasab, B; Khan, ZH; Majedi, H; Rabiee, M, 2002) |
| " retention of metoclopramide with tourniquet is as good as lidocaine and may be a useful alternative for reducing pain on propofol injection." | 9.09 | Pain on injection of propofol: the mitigating influence of metoclopramide using different techniques. ( Chang, DP; Hwang, MH; Liaw, WJ; Pang, WW, 1999) |
| "To determine whether postoperative pain and nausea after laparoscopic sterilization can be reduced with a combination of bupivacaine, metoclopramide, scopolamine, ketorolac, and gastric suctioning." | 9.08 | Reduction of pain and nausea after laparoscopic sterilization with bupivacaine, metoclopramide, scopolamine, ketorolac, and gastric suctioning. ( Bradford, TH; Meeks, GR; Norman, PF; Robertson, K, 1995) |
| "Lignocaine has been shown to reduce the incidence of pain on injection of propofol." | 9.07 | Propofol injection pain: comparing the addition of lignocaine or metoclopramide. ( Mecklem, DW, 1994) |
| "We have conducted a randomized, double-blind study in 255 ASA I and II patients to compare the efficacy of lignocaine and metoclopramide in minimizing the pain of injection of i." | 9.07 | Pain on injection of propofol: comparison of lignocaine with metoclopramide. ( Fee, JP; Ganta, R, 1992) |
| "After discussing the aetiological role of the reflux from the duodenum in causing and maintenance of chronic gastritis, the author studied the effect of bromopride, a drug regulating gastrointestinal motility, on the subjective complaints of individuals suffering from the disease." | 9.05 | [Treatment of upper-abdominal pain in chronic gastritis. Results of therapy with the motility regulating drug Bromopride]. ( Cartsburg, R; Fischer, M, 1980) |
| "Although pain is one of the most common side effects encountered with medical abortion, little is known about optimal pain management for this process." | 6.82 | Two prophylactic medication approaches in addition to a pain control regimen for early medical abortion < 63 days' gestation with mifepristone and misoprostol: study protocol for a randomized, controlled trial. ( Dragoman, MV; Dung, DL; Grossman, D; Habib, N; Huong, NM; Kapp, N; Tamang, A, 2016) |
| "Nausea and emesis are common side effects of opioid drugs administered for pain relief in cancer patients." | 6.70 | A double-blind, randomised, parallel group, multinational, multicentre study comparing a single dose of ondansetron 24 mg p.o. with placebo and metoclopramide 10 mg t.d.s. p.o. in the treatment of opioid-induced nausea and emesis in cancer patients. ( Albertsson, M; Chimontsi-Kypriou, V; Curtis, P; Daly, S; Hardy, J; McQuade, B; Stathopoulos, P, 2002) |
| "The incidence of pain upon injection of propofol-lipuro is low in comparison with incidence rates reported in the literature for the traditional formula, but administration of the fat emulsion formula through a vein on the dorsal side of the hand or through a venous catheter smaller than 18 G should be avoided." | 6.21 | [Incidence of pain upon injection of a new formula of propofol in a fat emulsion of medium- and long-chain triglycerides]. ( Ayuso, MA; Fernández, J; Gomar, C; Luis, M; Sala, X, 2004) |
| "Metoclopramide has in previous studies been found to be synergic with acupuncture analgesia both in the laboratory and in the clinics." | 5.27 | No synergism between metoclopramide and acupuncture in chronic pain. ( Junnila, SY, 1986) |
| "Ketorolac may have similar efficacy to phenothiazines and metoclopramide in treating acute migraine headache." | 5.22 | Efficacy of ketorolac in the treatment of acute migraine attack: A systematic review and meta-analysis. ( Abu Bakar, MA; Baharuddin, KA; Norhayati, MN; Nurathirah, MN; Yazid, MB, 2022) |
| "Propofol injection is known to cause distressing pain, and various methods have been used to decrease this pain." | 5.17 | A prospective, randomized, double-blind study to compare the efficacy of lidocaine + metoclopramide and lidocaine + ketamine combinations in preventing pain on propofol injection. ( Chaudhary, K; Gogia, AR; Gupta, P, 2013) |
| "Analysis by time yielded no statistically significant difference in VAS scores between the groups at any point except 16-20 hours after induction of labor, when pain was lower in the tramadol group (11." | 5.16 | Tramadol-metoclopramide or remifentanil for patient-controlled analgesia during second trimester abortion: a double-blinded, randomized controlled trial. ( Chinchuck, A; Eidelman, LA; Nichinson, E; Nitke, S; Orbach-Zinger, S; Paul-Keslin, L, 2012) |
| "Lidocaine and metoclopramide were equally and the most effective treatments in attenuating pain during intravenous injection of propofol compared to pretreatment with remifentanil and ketamine." | 5.16 | The effects of remifentanil, lidocaine, metoclopramide, or ketamine pretreatment on propofol injection pain. ( Aktay, M; Ozlü, O; Polat, R, 2012) |
| "The aim of this study was to compare the efficacy of lidocaine, metoclopramide, and flurbiprofen axetil for reducing pain on injection of propofol in Japanese adult surgical patients." | 5.13 | Comparison of lidocaine, metoclopramide, and flurbiprofen axetil for reducing pain on injection of propofol in Japanese adult surgical patients: a prospective, randomized, double-blind, parallel-group, placebo-controlled study. ( Fujii, Y; Itakura, M, 2008) |
| "Whether nitrous oxide (N(2)O) increases the incidence of postoperative nausea and vomiting (PONV) after laparoscopic gynecologic surgery is still controversial, which may be due to the administration of different concentrations of inspired N(2)O." | 5.13 | The dose-response of nitrous oxide in postoperative nausea in patients undergoing gynecologic laparoscopic surgery: a preliminary study. ( Gan, TJ; Mraovic, B; Simurina, T; Skitarelic, N; Sonicki, Z, 2008) |
| "Among these 240 Japanese patients undergoing elective surgery, N administration of LID/MET 40/5 or 40/10 was associated with lower incidence, but not lower mean pain intensity scores, of pain on injection of propofol than LID/MET 40/2." | 5.12 | Prevention of pain due to injection of propofol with IV administration of lidocaine 40 mg + metoclopramide 2.5, 5, or 10 mg or saline: a randomized, double-blind study in Japanese adult surgical patients. ( Fujii, Y; Nakayama, M, 2007) |
| "A randomised controlled trial was carried out on patients requiring morphine for acute pain in the emergency department (ED) setting." | 5.12 | Use of a prophylactic antiemetic with morphine in acute pain: randomised controlled trial. ( Bradshaw, M; Sen, A, 2006) |
| "Pain on injection is still a major problem with propofol; metoclopramide effectively decreases this pain." | 5.12 | Age-related differences in metoclopramide requirement for pain on injection of propofol. ( Fujii, Y; Shiga, Y, 2006) |
| "5 mg, 5 mg, 10 mg) for reducing pain on injection of propofol in 100 patients scheduled for elective surgery." | 5.11 | Effect of metoclopramide on pain on injection of propofol. ( Fujii, Y; Uemura, A, 2004) |
| "Aim of this study was to demonstrate that intravenous metoclopramide can reduce pain, nausea and discomfort during nasogastric tube (NGT) insertion in ED." | 5.11 | Effectiveness of pre-emptive metoclopramide infusion in alleviating pain, discomfort and nausea associated with nasogastric tube insertion: a randomised, double-blind, placebo-controlled trial. ( Karaca, MA; Ozucelik, DN; Sivri, B, 2005) |
| "25 patients (83%) complained of pain in the placebo group, compared with 12 (40%) in the lidocaine group (P < 0." | 5.11 | A lidocaine/metoclopramide combination decreases pain on injection of propofol. ( Fujii, Y; Nakayama, M, 2005) |
| "Metoclopramide, rather than lidocaine pretreatment, may be a reasonable analgesic alternative to decrease pain from a diazepam injection, especially when there is a medical condition in which lidocaine should be used very cautiously." | 5.10 | A comparison of metoclopramide and lidocaine for preventing pain on injection of diazepam. ( Hassannasab, B; Khan, ZH; Majedi, H; Rabiee, M, 2002) |
| " retention of metoclopramide with tourniquet is as good as lidocaine and may be a useful alternative for reducing pain on propofol injection." | 5.09 | Pain on injection of propofol: the mitigating influence of metoclopramide using different techniques. ( Chang, DP; Hwang, MH; Liaw, WJ; Pang, WW, 1999) |
| "To determine whether postoperative pain and nausea after laparoscopic sterilization can be reduced with a combination of bupivacaine, metoclopramide, scopolamine, ketorolac, and gastric suctioning." | 5.08 | Reduction of pain and nausea after laparoscopic sterilization with bupivacaine, metoclopramide, scopolamine, ketorolac, and gastric suctioning. ( Bradford, TH; Meeks, GR; Norman, PF; Robertson, K, 1995) |
| "Two hundred and seventy-eight patients scheduled for all types of surgery and premedicated with diazepam and metoclopramide were randomly allocated to one of four groups to compare the relative pain of an injection of 0." | 5.08 | Rationalizing venepuncture pain: comparison of lignocaine injection, Butterfly (21 gauge and 23 gauge) and Venflon (20 gauge). ( Prabhu, NV; Van den Berg, AA, 1995) |
| " Metoclopramide and droperidol had no significant effect on postoperative vomiting." | 5.07 | Prophylactic antiemetic treatment with ondansetron in children undergoing tonsillectomy. ( Furst, SR; Rodarte, A, 1994) |
| "Lignocaine has been shown to reduce the incidence of pain on injection of propofol." | 5.07 | Propofol injection pain: comparing the addition of lignocaine or metoclopramide. ( Mecklem, DW, 1994) |
| "We have conducted a randomized, double-blind study in 255 ASA I and II patients to compare the efficacy of lignocaine and metoclopramide in minimizing the pain of injection of i." | 5.07 | Pain on injection of propofol: comparison of lignocaine with metoclopramide. ( Fee, JP; Ganta, R, 1992) |
| "This randomized, double-blind trial evaluated the effect of metoclopramide on the pain and analgesic requirements associated with prostaglandin-induced labor for second-trimester termination of pregnancy." | 5.07 | Metoclopramide: an analgesic adjunct to patient-controlled analgesia. ( Cioffi, AM; Rosenblatt, WH; Saberski, LR; Silverman, DG; Sinatra, R, 1991) |
| "After discussing the aetiological role of the reflux from the duodenum in causing and maintenance of chronic gastritis, the author studied the effect of bromopride, a drug regulating gastrointestinal motility, on the subjective complaints of individuals suffering from the disease." | 5.05 | [Treatment of upper-abdominal pain in chronic gastritis. Results of therapy with the motility regulating drug Bromopride]. ( Cartsburg, R; Fischer, M, 1980) |
| "ESL interacted in a beneficial manner with several analgesics that are used for trigeminal pain treatment, producing synergistic interactions with naproxen/metoclopramide and additive interactions with paracetamol/propyphenazone/zolmitriptan." | 3.96 | Eslicarbazepine acetate interacts in a beneficial manner with standard and alternative analgesics to reduce trigeminal nociception. ( Micov, A; Pecikoza, U; Stepanović-Petrović, R; Tomić, M; Vuković, M, 2020) |
| "Morphine is co-administered with adjuvant drugs to treat pain, nausea, vomiting, dyspnoea and delirium in cancer patients." | 3.80 | Analgesic effects of morphine in combination with adjuvant drugs in rats. ( Kaminska, E; Leppert, W; Mikolajczak, P; Okulicz-Kozaryn, I; Szulc, M, 2014) |
| "Although pain is one of the most common side effects encountered with medical abortion, little is known about optimal pain management for this process." | 2.82 | Two prophylactic medication approaches in addition to a pain control regimen for early medical abortion < 63 days' gestation with mifepristone and misoprostol: study protocol for a randomized, controlled trial. ( Dragoman, MV; Dung, DL; Grossman, D; Habib, N; Huong, NM; Kapp, N; Tamang, A, 2016) |
| "Nausea and emesis are common side effects of opioid drugs administered for pain relief in cancer patients." | 2.70 | A double-blind, randomised, parallel group, multinational, multicentre study comparing a single dose of ondansetron 24 mg p.o. with placebo and metoclopramide 10 mg t.d.s. p.o. in the treatment of opioid-induced nausea and emesis in cancer patients. ( Albertsson, M; Chimontsi-Kypriou, V; Curtis, P; Daly, S; Hardy, J; McQuade, B; Stathopoulos, P, 2002) |
| "None of these differences reached statistical significance." | 2.69 | Prophylactic metoclopramide is unnecessary with intravenous analgesia in the ED. ( Paoloni, R; Talbot-Stern, J, 2000) |
| " Patients were allocated at random to receive 2 tablets 3-times daily of either treatment for 6 weeks and were then crossed over to the alternative treatment at the same dosage for a further 6 weeks." | 2.65 | Paracetamol plus metoclopramide ('Paramax') as an adjunct analgesic in the treatment of arthritis. ( Boston, PF; Matts, SG, 1983) |
| "For a modern approach to the treatment of pain, a new form of communication that puts emphasis on the need for empathy with the patient is indispensable." | 2.42 | [Current pain therapy in the doctor's office]. ( Sohn, W, 2003) |
| "PONV was experienced by 74." | 1.91 | Prevalence, Risk Factors, and Management of Postoperative Nausea and Vomiting After Laparoscopic Sleeve Gastrectomy (a Retrospective Multicentric Study). ( Abuyousif, YA; Aldossary, HM; Attia, M; El Hefnawy, E; El Nakeeb, A; Elmorshedi, M; Mohammed, MN; Rashad, AE; Salem, A; Zaid, A, 2023) |
| "Metoclopramide has in previous studies been found to be synergic with acupuncture analgesia both in the laboratory and in the clinics." | 1.27 | No synergism between metoclopramide and acupuncture in chronic pain. ( Junnila, SY, 1986) |
| "Magnesium deficiency was present in seven patients and its correction resulted in amelioration of the symptom complex." | 1.26 | Chronic intestinal pseudo-obstruction. ( Brandenburg, D; Brooks, WS; Hersh, T; Hirsh, EH, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (22.22) | 18.7374 |
| 1990's | 11 (20.37) | 18.2507 |
| 2000's | 20 (37.04) | 29.6817 |
| 2010's | 8 (14.81) | 24.3611 |
| 2020's | 3 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Nurathirah, MN | 1 |
| Yazid, MB | 1 |
| Norhayati, MN | 1 |
| Baharuddin, KA | 1 |
| Abu Bakar, MA | 1 |
| Rashad, AE | 1 |
| El Hefnawy, E | 1 |
| Elmorshedi, M | 1 |
| Abuyousif, YA | 1 |
| Salem, A | 1 |
| Attia, M | 1 |
| El Nakeeb, A | 1 |
| Zaid, A | 1 |
| Aldossary, HM | 1 |
| Mohammed, MN | 1 |
| Pecikoza, U | 1 |
| Tomić, M | 1 |
| Micov, A | 1 |
| Vuković, M | 1 |
| Stepanović-Petrović, R | 1 |
| Seki, H | 1 |
| Furumoto, K | 1 |
| Sato, M | 1 |
| Kagoya, A | 1 |
| Hashimoto, H | 1 |
| Sekiguchi, Y | 1 |
| Nakatsuka, I | 1 |
| Frez, C | 1 |
| Awad, Y | 1 |
| Sánchez, N | 1 |
| Silva, A | 1 |
| Mercado, B | 1 |
| Marcotti, C | 1 |
| Arévalo, P | 1 |
| Apablaza, K | 1 |
| Fernández, P | 1 |
| Pérez, D | 1 |
| Leppert, W | 1 |
| Okulicz-Kozaryn, I | 1 |
| Kaminska, E | 1 |
| Szulc, M | 1 |
| Mikolajczak, P | 1 |
| Tsukuura, H | 1 |
| Ando, Y | 1 |
| Gyawali, B | 1 |
| Matsumoto, M | 1 |
| Sugishita, M | 1 |
| Honda, K | 1 |
| Urakawa, H | 1 |
| Maeda, O | 1 |
| Hasegawa, Y | 1 |
| Dragoman, MV | 1 |
| Grossman, D | 1 |
| Kapp, N | 1 |
| Huong, NM | 1 |
| Habib, N | 1 |
| Dung, DL | 1 |
| Tamang, A | 1 |
| Mraovic, B | 1 |
| Simurina, T | 1 |
| Sonicki, Z | 1 |
| Skitarelic, N | 1 |
| Gan, TJ | 1 |
| Yeoh, BS | 1 |
| Taylor, DM | 1 |
| Taylor, SE | 1 |
| Orbach-Zinger, S | 1 |
| Paul-Keslin, L | 1 |
| Nichinson, E | 1 |
| Chinchuck, A | 1 |
| Nitke, S | 1 |
| Eidelman, LA | 1 |
| Chaudhary, K | 1 |
| Gupta, P | 1 |
| Gogia, AR | 1 |
| Polat, R | 1 |
| Aktay, M | 1 |
| Ozlü, O | 1 |
| Woodall, HE | 1 |
| Majedi, H | 1 |
| Rabiee, M | 1 |
| Khan, ZH | 2 |
| Hassannasab, B | 1 |
| Sohn, W | 1 |
| Fujii, Y | 5 |
| Uemura, A | 1 |
| Ayuso, MA | 1 |
| Luis, M | 1 |
| Sala, X | 1 |
| Fernández, J | 1 |
| Gomar, C | 1 |
| Movafegh, A | 1 |
| Gharehdaghi, FA | 1 |
| Shoeibi, G | 1 |
| Nakayama, M | 2 |
| Wood, C | 1 |
| Ozucelik, DN | 1 |
| Karaca, MA | 1 |
| Sivri, B | 1 |
| Bradshaw, M | 1 |
| Sen, A | 1 |
| Gupta, VK | 1 |
| Rösch, W | 1 |
| Liebregts, T | 1 |
| Gundermann, KJ | 1 |
| Vinson, B | 1 |
| Holtmann, G | 1 |
| Shiga, Y | 1 |
| Koh, YH | 1 |
| Wu, HY | 1 |
| Lim, WP | 1 |
| Itakura, M | 1 |
| Farthmann, EH | 1 |
| Fritsch, WP | 1 |
| Cameron, PF | 1 |
| Feldman, M | 1 |
| Schiller, LR | 1 |
| Matts, SG | 1 |
| Boston, PF | 1 |
| Hirsh, EH | 1 |
| Brandenburg, D | 1 |
| Hersh, T | 1 |
| Brooks, WS | 1 |
| Bright-Asare, P | 1 |
| El-Bassoussi, M | 1 |
| Cartsburg, R | 1 |
| Fischer, M | 1 |
| Bradford, TH | 1 |
| Robertson, K | 1 |
| Norman, PF | 1 |
| Meeks, GR | 1 |
| Van den Berg, AA | 1 |
| Prabhu, NV | 1 |
| Mecklem, DW | 1 |
| Furst, SR | 1 |
| Rodarte, A | 1 |
| Kandler, D | 1 |
| Lisander, B | 1 |
| Wilkinson, DJ | 1 |
| Liaw, WJ | 1 |
| Pang, WW | 1 |
| Chang, DP | 1 |
| Hwang, MH | 1 |
| Talbot-Stern, J | 1 |
| Paoloni, R | 1 |
| Hardy, J | 1 |
| Daly, S | 1 |
| McQuade, B | 1 |
| Albertsson, M | 1 |
| Chimontsi-Kypriou, V | 1 |
| Stathopoulos, P | 1 |
| Curtis, P | 1 |
| Ganta, R | 1 |
| Fee, JP | 1 |
| Smith, M | 1 |
| Skewes, A | 1 |
| Darnell, JD | 1 |
| Sufka, KJ | 1 |
| Giordano, J | 1 |
| Rosenblatt, WH | 1 |
| Cioffi, AM | 1 |
| Sinatra, R | 1 |
| Saberski, LR | 1 |
| Silverman, DG | 1 |
| Junnila, SY | 1 |
| Geller, LI | 1 |
| Petrenko, VF | 1 |
| Venning, M | 1 |
| Rogers, J | 1 |
| Garewal, HS | 1 |
| Dalton, WS | 1 |
| Vella, L | 1 |
| Francis, D | 1 |
| Houlton, P | 1 |
| Reynolds, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Evaluation of the Combination of Magnesium and Lidocaine for the Pretreatment of Pain That is Caused by the Injection of Propofol.[NCT01342510] | Phase 4 | 200 participants (Actual) | Interventional | 2011-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Ten seconds following injection of propofol, subjects were asked Are you having pain at your IV site? Any behavioral signs were noted. Injection pain was assessed using the following four point scale: 0 = no pain; 1 = mild pain (pain reported only in response to questioning and without behavioral signs); 2 = moderate pain (pain reported in response to questioning and accompanied by a behavioral sign, or pain reported spontaneously without questioning); and 3 = severe pain (strong vocal response or response accompanied by facial grimacing, arm withdrawal, or tears)." (NCT01342510)
Timeframe: < 1 minute.
| Intervention | participants reporting pain (Number) |
|---|---|
| Lidocaine | 11 |
| Magnesium | 25 |
| Lidocaine/Magnesium | 15 |
| Control | 18 |
Following injection of the study drug, 50 mg of propofol will be injected. Ten seconds after propofol, subjects will be asked a standard question about pain. Behavioral signs will be noted. Pain will be assessed using a four point scale: 0=no pain, 1=mild pain (pain reported only in response to questioning and without behavioral signs), 2=moderate pain (pain reported in response to questioning and a behavioral sign, or pain reported without questioning), 3=severe pain (strong vocal response or behavioral response). (NCT01342510)
Timeframe: Approximately 10 seconds following administration of propofol.
| Intervention | percentage of patients reporting pain (Number) |
|---|---|
| Lidocaine | 29 |
| Magnesium | 57 |
| Lidocaine/Magnesium | 41 |
| Control | 46 |
5 reviews available for metoclopramide and Pain
| Article | Year |
|---|---|
Efficacy of ketorolac in the treatment of acute migraine attack: A systematic review and meta-analysis.
Topics: Caffeine; Dexamethasone; Diclofenac; Humans; Ketorolac; Metoclopramide; Migraine Disorders; Pain; Ph | 2022 |
[Current pain therapy in the doctor's office].
Topics: Administration, Oral; Adult; Aged; Analgesics; Analgesics, Opioid; Back Pain; Dopamine Antagonists; | 2003 |
[Incidence of pain upon injection of a new formula of propofol in a fat emulsion of medium- and long-chain triglycerides].
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Emulsions; Female; Humans; Incidence; Lidocaine; Male; | 2004 |
Phytotherapy for functional dyspepsia: a review of the clinical evidence for the herbal preparation STW 5.
Topics: Antiemetics; Cisapride; Cohort Studies; Double-Blind Method; Dyspepsia; Gastrointestinal Agents; Hum | 2006 |
Disorders of gastrointestinal motility associated with diabetes mellitus.
Topics: Autonomic Nervous System Diseases; Bethanechol Compounds; Constipation; Diabetes Complications; Diab | 1983 |
30 trials available for metoclopramide and Pain
| Article | Year |
|---|---|
Effects of epidural anesthesia on postoperative nausea and vomiting in laparoscopic gynecological surgery: a randomized controlled trial.
Topics: Adult; Analgesics, Opioid; Anesthesia, Epidural; Anesthesia, General; Antiemetics; Female; Fentanyl; | 2018 |
Two prophylactic medication approaches in addition to a pain control regimen for early medical abortion < 63 days' gestation with mifepristone and misoprostol: study protocol for a randomized, controlled trial.
Topics: Abortifacient Agents, Nonsteroidal; Abortifacient Agents, Steroidal; Abortion, Induced; Adolescent; | 2016 |
The dose-response of nitrous oxide in postoperative nausea in patients undergoing gynecologic laparoscopic surgery: a preliminary study.
Topics: Adult; Aged; Anesthesia; Dose-Response Relationship, Drug; Female; Gynecologic Surgical Procedures; | 2008 |
Tramadol-metoclopramide or remifentanil for patient-controlled analgesia during second trimester abortion: a double-blinded, randomized controlled trial.
Topics: Abortion, Induced; Academic Medical Centers; Adult; Analgesia, Patient-Controlled; Analgesics, Opioi | 2012 |
A prospective, randomized, double-blind study to compare the efficacy of lidocaine + metoclopramide and lidocaine + ketamine combinations in preventing pain on propofol injection.
Topics: Adult; Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, Intravenous; Anesthetics, Loca | 2013 |
The effects of remifentanil, lidocaine, metoclopramide, or ketamine pretreatment on propofol injection pain.
Topics: Adult; Aged; Analgesics; Double-Blind Method; Female; Humans; Injections, Intravenous; Ketamine; Lid | 2012 |
A comparison of metoclopramide and lidocaine for preventing pain on injection of diazepam.
Topics: Adjuvants, Anesthesia; Adult; Aged; Anesthetics, Local; Diazepam; Double-Blind Method; Female; Human | 2002 |
Effect of metoclopramide on pain on injection of propofol.
Topics: Adult; Aged; Analysis of Variance; Anesthesia, General; Chi-Square Distribution; Dose-Response Relat | 2004 |
[Incidence of pain upon injection of a new formula of propofol in a fat emulsion of medium- and long-chain triglycerides].
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Emulsions; Female; Humans; Incidence; Lidocaine; Male; | 2004 |
Dexamethasone dose attenuates pain on injection following diazepam hydrochloride.
Topics: Adult; Dexamethasone; Diazepam; Double-Blind Method; Humans; Injections; Male; Metoclopramide; Middl | 2005 |
A lidocaine/metoclopramide combination decreases pain on injection of propofol.
Topics: Adult; Anesthetics, Intravenous; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Inj | 2005 |
Effectiveness of pre-emptive metoclopramide infusion in alleviating pain, discomfort and nausea associated with nasogastric tube insertion: a randomised, double-blind, placebo-controlled trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antiemetics; Double-Blind Method; Female; Gagging; Human | 2005 |
Use of a prophylactic antiemetic with morphine in acute pain: randomised controlled trial.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Antiemetics; Female; | 2006 |
Age-related differences in metoclopramide requirement for pain on injection of propofol.
Topics: Adult; Aged; Aging; Double-Blind Method; Female; Humans; Injections; Male; Metoclopramide; Middle Ag | 2006 |
Prevention of pain due to injection of propofol with IV administration of lidocaine 40 mg + metoclopramide 2.5, 5, or 10 mg or saline: a randomized, double-blind study in Japanese adult surgical patients.
Topics: Adult; Aged; Anesthetics, Intravenous; Anesthetics, Local; Antiemetics; Dose-Response Relationship, | 2007 |
Comparison of lidocaine, metoclopramide, and flurbiprofen axetil for reducing pain on injection of propofol in Japanese adult surgical patients: a prospective, randomized, double-blind, parallel-group, placebo-controlled study.
Topics: Adult; Aged; Analgesics; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; Female; | 2008 |
Paracetamol plus metoclopramide ('Paramax') as an adjunct analgesic in the treatment of arthritis.
Topics: Acetaminophen; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Drug Combinations; Humans; Metoclopr | 1983 |
Cimetidine, metoclopramide, or placebo in the treatment of symptomatic gastroesophageal reflux.
Topics: Adult; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Female; Gastroesophageal Reflux; G | 1980 |
[Treatment of upper-abdominal pain in chronic gastritis. Results of therapy with the motility regulating drug Bromopride].
Topics: Abdomen; Drug Evaluation; Female; Gastritis; Gastrointestinal Motility; Humans; Male; Metoclopramide | 1980 |
Reduction of pain and nausea after laparoscopic sterilization with bupivacaine, metoclopramide, scopolamine, ketorolac, and gastric suctioning.
Topics: Analgesics, Non-Narcotic; Bupivacaine; Combined Modality Therapy; Female; Humans; Ketorolac; Laparos | 1995 |
Rationalizing venepuncture pain: comparison of lignocaine injection, Butterfly (21 gauge and 23 gauge) and Venflon (20 gauge).
Topics: Adolescent; Adult; Bloodletting; Catheterization, Peripheral; Diazepam; Equipment Design; Female; Hu | 1995 |
Propofol injection pain: comparing the addition of lignocaine or metoclopramide.
Topics: Adult; Anesthesia Recovery Period; Anesthesia, Intravenous; Blood Pressure; Extrapyramidal Tracts; F | 1994 |
Prophylactic antiemetic treatment with ondansetron in children undergoing tonsillectomy.
Topics: Acetaminophen; Antiemetics; Child; Child, Preschool; Double-Blind Method; Droperidol; Female; Humans | 1994 |
Analgesic action of metoclopramide in prosthetic hip surgery.
Topics: Aged; Anesthesia, Spinal; Bupivacaine; Double-Blind Method; Female; Hip Prosthesis; Humans; Infusion | 1993 |
Pain on injection of propofol: the mitigating influence of metoclopramide using different techniques.
Topics: Adult; Analgesics; Analysis of Variance; Anesthetics, Intravenous; Anesthetics, Local; Chi-Square Di | 1999 |
Prophylactic metoclopramide is unnecessary with intravenous analgesia in the ED.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesia; Analgesics, Opioid; Antiemetics; Double-Blind | 2000 |
A double-blind, randomised, parallel group, multinational, multicentre study comparing a single dose of ondansetron 24 mg p.o. with placebo and metoclopramide 10 mg t.d.s. p.o. in the treatment of opioid-induced nausea and emesis in cancer patients.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Antiemetics; Double-Blind Method; Female; Humans | 2002 |
Pain on injection of propofol: comparison of lignocaine with metoclopramide.
Topics: Adolescent; Adult; Aged; Double-Blind Method; Female; Humans; Injections, Intravenous; Lidocaine; Ma | 1992 |
Metoclopramide: an analgesic adjunct to patient-controlled analgesia.
Topics: Abortion, Induced; Adult; Analgesia, Patient-Controlled; Double-Blind Method; Female; Humans; Labor, | 1991 |
Comparison of the antiemetics metoclopramide and promethazine in labour.
Topics: Clinical Trials as Topic; Consciousness; Double-Blind Method; Female; Humans; Meperidine; Metoclopra | 1985 |
20 other studies available for metoclopramide and Pain
| Article | Year |
|---|---|
Prevalence, Risk Factors, and Management of Postoperative Nausea and Vomiting After Laparoscopic Sleeve Gastrectomy (a Retrospective Multicentric Study).
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Dexamethasone; Female; Gastrectomy; Gastroesophageal Re | 2023 |
Eslicarbazepine acetate interacts in a beneficial manner with standard and alternative analgesics to reduce trigeminal nociception.
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Dibenz | 2020 |
[Extrapyramidal adverse reactions to metoclopramide. A pharmacovigilance survey].
Topics: Chile; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Dopamine D2 Receptor Antagonists; Female; | 2018 |
Analgesic effects of morphine in combination with adjuvant drugs in rats.
Topics: Adjuvants, Pharmaceutic; Analgesics, Opioid; Animals; Butylscopolammonium Bromide; Drug Interactions | 2014 |
Prophylactic Use of Antiemetics for Prevention of Opioid-Induced Nausea and Vomiting: A Questionnaire Survey among Japanese Physicians.
Topics: Analgesics, Opioid; Antiemetics; Benzodiazepines; Chemoprevention; Domperidone; Health Care Surveys; | 2015 |
Education initiative improves the evidence-based use of metoclopramide following morphine administration in the emergency department.
Topics: Acute Disease; Analgesics, Opioid; Antiemetics; Chi-Square Distribution; Emergency Medicine; Emergen | 2009 |
Alternatives to rehydration during hypodermoclysis.
Topics: Analgesics, Opioid; Fluid Therapy; Humans; Infusions, Parenteral; Metoclopramide; Nausea; Pain; Pall | 2002 |
New strategy to ease the discomfort of insertion of nasogastric tubes.
Topics: Adult; Antiemetics; Gagging; Humans; Infusions, Intravenous; Intubation, Gastrointestinal; Metoclopr | 2005 |
Metoclopramide is not an analgesic: reflection on a premature scientific conclusion.
Topics: Analgesics; Humans; Intubation, Gastrointestinal; Metoclopramide; Pain | 2006 |
Pain and nausea in malignant pheochromocytoma: a pharmacological minefield.
Topics: Adrenal Gland Neoplasms; Analgesics, Opioid; Antiemetics; Fatal Outcome; Female; Humans; Lymphatic M | 2008 |
[Conditions after total gastrectomy].
Topics: Adenocarcinoma; Anemia, Hypochromic; Antacids; Cholestyramine Resin; Dumping Syndrome; Esophagitis, | 1982 |
Strained abdominal muscles as a cause of acute abdominal pain in children and young adults and its treatment with Paramax.
Topics: Abdomen; Abdominal Muscles; Acetaminophen; Adolescent; Adult; Child; Drug Combinations; Female; Huma | 1983 |
Chronic intestinal pseudo-obstruction.
Topics: Adult; Aged; Celiac Disease; Chronic Disease; Female; Humans; Intestinal Obstruction; Intestinal Pse | 1981 |
Pain on i.v. injection of metoclopramide.
Topics: Humans; Injections, Intravenous; Metoclopramide; Pain | 1993 |
In pursuit of nursing excellence.
Topics: Adult; Aged; Aged, 80 and over; Analgesia, Patient-Controlled; Arthritis; Basal Ganglia Diseases; Co | 1992 |
Analgesic effects of S and R isomers of the novel 5-HT3 receptor antagonists ADR-851 and ADR-882 in rats.
Topics: Analgesics; Animals; Behavior, Animal; Benzofurans; Bridged Bicyclo Compounds; Bridged Bicyclo Compo | 1991 |
No synergism between metoclopramide and acupuncture in chronic pain.
Topics: Acupuncture Therapy; Adult; Chronic Disease; Combined Modality Therapy; Double-Blind Method; Female; | 1986 |
[Disorders of esophageal motility as a cause of retrosternal pain].
Topics: Adult; Diagnosis, Differential; Esophageal Diseases; Esophagitis, Peptic; Female; Gastrointestinal M | 1986 |
Continuous subcutaneous infusion: flexible option in symptom control.
Topics: Anxiety; Female; Haloperidol; Humans; Infusion Pumps; Infusions, Parenteral; Metoclopramide; Middle | 1988 |
Metoclopramide in vincristine-induced ileus.
Topics: Aged; Constipation; Gastrointestinal Motility; Humans; Intestinal Obstruction; Leukemia, Lymphoid; L | 1985 |