metoclopramide has been researched along with Pain, Postoperative in 36 studies
Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.
metoclopramide : A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.
Pain, Postoperative: Pain during the period after surgery.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ondansetron has a well documented antiemetic prophylactic effect, whereas in most studies of postoperative nausea and vomiting (PONV), metoclopramide is less efficacious." | 9.10 | Incidence and severity of postoperative nausea and vomiting are similar after metoclopramide 20 mg and ondansetron 8 mg given by the end of laparoscopic cholecystectomies. ( Quaynor, H; Raeder, JC, 2002) |
| " Intravenous ondansetron and tropisetron prevent postoperative nausea and vomiting (PONV) at least as efficiently as traditional antiemetics, droperidol and metoclopramide." | 9.10 | Oral ondansetron, tropisetron or metoclopramide to prevent postoperative nausea and vomiting: a comparison in high-risk patients undergoing thyroid or parathyroid surgery. ( Alahuhta, S; Jokela, R; Kangas-Saarela, T; Koivuranta, M; Purhonen, S, 2002) |
| ") doses of ondansetron 8 mg, ondansetron 16 mg and metoclopramide 10 mg in the treatment of opioid-induced emesis." | 9.09 | Ondansetron is more effective than metoclopramide for the treatment of opioid-induced emesis in post-surgical adult patients. Ondansetron OIE Post-Surgical Study Group. ( Alahuta, S; Chung, F; Curtis, P; Duvaldestin, P; Jacka, M; Lane, R; Luttropp, HH; McQuade, B; Rocherieux, S; Roy, M; Spraggs, C, 1999) |
| "Dolasetron reduced the postoperative nausea and vomiting score significantly (P < 0." | 9.09 | Placebo-controlled comparison of dolasetron and metoclopramide in preventing postoperative nausea and vomiting in patients undergoing hysterectomy. ( Boldt, J; Fent, MT; Hüttner, I; Maleck, WH; Piper, SN; Triem, JG, 2001) |
| "The efficacy of ondansetron 4 mg was compared with metoclopramide 10 mg for the prevention of post-operative nausea and vomiting in patients after major gynaecological abdominal surgery." | 9.08 | Comparison of ondansetron and metoclopramide for the prevention of post-operative nausea and vomiting after major gynaecological surgery. ( Chen, PP; Chui, PT; Gin, T, 1996) |
| " Incidences of postoperative nausea and vomiting, number of patients requiring antiemetic rescue, and overall consumption of metoclopramide were lower in groups B and C than in group A (all P < ." | 5.27 | Multiple Doses of Perioperative Dexamethasone Further Improve Clinical Outcomes After Total Knee Arthroplasty: A Prospective, Randomized, Controlled Study. ( Cao, G; Lei, Y; Pei, F; Xie, J; Xu, H; Zhang, S, 2018) |
| "the objective of this study was to assess whether antiemetic drugs metoclopramide and diphenhydramine, administered together as opposed to alone, can have better efficacy in preventing postoperative nausea and vomiting when added to patient-controlled morphine analgesia." | 5.14 | Antiemetic efficacy of metoclopramide and diphenhydramine added to patient-controlled morphine analgesia: a randomised controlled trial. ( Jean, WH; Lin, TY; Lu, CW; Shieh, JS; Wu, CC, 2010) |
| " In addition postoperative morphine requirement, anxiety, and vomiting were not affected by the music during general anesthesia." | 5.12 | The impact of music on postoperative pain and anxiety following cesarean section. ( Abul-Qasim, A; Ali, SM; Reza, N; Reza, TH; Saeed, K, 2007) |
| "To assess the efficacy of metoclopramide (Met) for prevention of prolonged post-operative ileus in advanced gastric cancer patients undergoing D2 gastrectomy and intra-peritoneal chemotherapy (IPC)." | 5.11 | Preventing prolonged post-operative ileus in gastric cancer patients undergoing gastrectomy and intra-peritoneal chemotherapy. ( Chan, DC; Chang, TM; Chen, CJ; Chen, FC; Chen, TW; Chu, HC; Hsieh, HF; Liu, YC; Shen, KL; Yu, JC, 2005) |
| "Ondansetron has a well documented antiemetic prophylactic effect, whereas in most studies of postoperative nausea and vomiting (PONV), metoclopramide is less efficacious." | 5.10 | Incidence and severity of postoperative nausea and vomiting are similar after metoclopramide 20 mg and ondansetron 8 mg given by the end of laparoscopic cholecystectomies. ( Quaynor, H; Raeder, JC, 2002) |
| " Intravenous ondansetron and tropisetron prevent postoperative nausea and vomiting (PONV) at least as efficiently as traditional antiemetics, droperidol and metoclopramide." | 5.10 | Oral ondansetron, tropisetron or metoclopramide to prevent postoperative nausea and vomiting: a comparison in high-risk patients undergoing thyroid or parathyroid surgery. ( Alahuhta, S; Jokela, R; Kangas-Saarela, T; Koivuranta, M; Purhonen, S, 2002) |
| ") doses of ondansetron 8 mg, ondansetron 16 mg and metoclopramide 10 mg in the treatment of opioid-induced emesis." | 5.09 | Ondansetron is more effective than metoclopramide for the treatment of opioid-induced emesis in post-surgical adult patients. Ondansetron OIE Post-Surgical Study Group. ( Alahuta, S; Chung, F; Curtis, P; Duvaldestin, P; Jacka, M; Lane, R; Luttropp, HH; McQuade, B; Rocherieux, S; Roy, M; Spraggs, C, 1999) |
| "Dolasetron reduced the postoperative nausea and vomiting score significantly (P < 0." | 5.09 | Placebo-controlled comparison of dolasetron and metoclopramide in preventing postoperative nausea and vomiting in patients undergoing hysterectomy. ( Boldt, J; Fent, MT; Hüttner, I; Maleck, WH; Piper, SN; Triem, JG, 2001) |
| "The efficacy of ondansetron 4 mg was compared with metoclopramide 10 mg for the prevention of post-operative nausea and vomiting in patients after major gynaecological abdominal surgery." | 5.08 | Comparison of ondansetron and metoclopramide for the prevention of post-operative nausea and vomiting after major gynaecological surgery. ( Chen, PP; Chui, PT; Gin, T, 1996) |
| "Postoperative nausea and vomiting (PONV) with morphine therapy develops in more than 60% of patients after surgery, markedly reducing patient QOL." | 4.81 | Evaluation of the effective drugs for the prevention of nausea and vomiting induced by morphine used for postoperative pain: a quantitative systematic review. ( Hirayama, T; Ishii, F; Ogata, H; Yago, K, 2001) |
| "In total knee and hip arthroplasty, methylprednisolone is effective in preventing postoperative nausea; however, higher doses of methylprednisolone may be needed to prevent vomiting." | 3.76 | Methylprednisolone reduces postoperative nausea in total knee and hip arthroplasty. ( Ejiri, M; Ishiguro, N; Kuzuya, T; Miyagawa, Y; Osada, T; Yamada, K, 2010) |
| "As metoclopramide is an antiemetic and an analgesic, it was hypothesized that when added to reduce PONV, metoclopromide may enhance the multimodal feature of tramadol by the analgesic property of metoclopramide." | 2.78 | Metoclopramide improves the quality of tramadol PCA indistinguishable to morphine PCA: a prospective, randomized, double blind clinical comparison. ( Chen, TX; Chois, JM; Liao, CC; Liu, YC; Maboudou, E; Pang, W; Wu, RS, 2013) |
| "The overall incidence and severity of postoperative nausea and the level of antiemetic consumption were significantly lower in group R compared with group D, and these parameters were significantly lower in groups R and D than in group C." | 2.78 | Effects of ramosetron and dexamethasone on postoperative nausea, vomiting, pain, and shivering in female patients undergoing thyroid surgery. ( Lee, C; Song, YK, 2013) |
| "Data of intraoperative variables, postoperative pain relief, rescue analgesic consumption, side effects, and patient satisfaction were followed in both groups." | 2.74 | Effects of intraperitoneal levobupivacaine on pain after laparoscopic cholecystectomy: a prospective, randomized, double-blinded study. ( Alper, I; Balcioğlu, T; Ertuğrul, V; Makay, O; Ulukaya, S; Uyar, M, 2009) |
| "Thus, with combined analgesic treatment, postoperative pain relieve can be achieved safely and without additional costs." | 2.70 | [Postoperative pain therapy in urology. A prospective study]. ( Benninghoff, A; Gronau, E; Pannek, J; Seibold, W; Senge, T, 2002) |
| "Metoclopramide traditionally has been used as a prokinetic and antiemetic, but recently it also has been investigated as an agent to enhance analgesic efficacy." | 2.70 | The morphine-sparing effect of metoclopramide on postoperative laparoscopic tubal ligation patients. ( Gibbs, RD; Movinsky, BA; Pellegrini, J; Vacchiano, CA, 2002) |
| "An intermittent intake of low-dose droperidol with morphine given via a PCA delivery system in two treatment groups gave evidence for a dose-response relation between the amount of droperidol added and the proportion of patients needing a rescue antiemetic." | 2.68 | Antiemetic efficacy of a droperidol-morphine combination in patient-controlled analgesia. ( Bach, T; Jackson, D; McKenzie, R; Riley, T; Tantisira, B, 1995) |
| "Metoclopramide may enhance opioid analgesia, but it is not known if the drug is analgesic itself." | 2.67 | Evaluation of the analgesic effect of metoclopramide after opioid-free analgesia. ( Lisander, B, 1993) |
| "Metoclopramide-treated patients did not demonstrate a lower incidence of nausea or emesis but did tolerate oral liquids earlier after surgery than the placebo group (P less than 0." | 2.67 | Outpatient cholecystectomy simulated in an inpatient population. ( Downes, TW; Hayes, DH; McKinnon, WM; Treen, DC, 1991) |
| "The analgesic effects of PCIA with sufentanil in combination with flurbiprofen axetil and dexmedetomidine on postoperative analgesia was better than that of traditional pure opioids PCIA, and similar with that of PCEA." | 1.72 | Analgesic effects of sufentanil in combination with flurbiprofen axetil and dexmedetomidine after open gastrointestinal tumor surgery: a retrospective study. ( Chen, YJ; Huang, J; Li, TT; Liu, F; Wang, TH; Xiong, LL; Yin, L, 2022) |
| " Additionally, a 1 ml bolus dosage was administered at a 60-minute lockout interval employing a pump which contained 36 mg of morphine hydrochloride, 30 mg of metoclopramide hydrochloride in 62 ml of physiologic saline." | 1.32 | Utilization of PCIA (patient-controlled intravenous analgesia) for postoperative analgesia of spine fusion. ( Hasegawa, J; Hirasawa, M; Nishiyama, J; Suzuki, T, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (5.56) | 18.7374 |
| 1990's | 11 (30.56) | 18.2507 |
| 2000's | 16 (44.44) | 29.6817 |
| 2010's | 6 (16.67) | 24.3611 |
| 2020's | 1 (2.78) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, F | 1 |
| Li, TT | 1 |
| Yin, L | 1 |
| Huang, J | 1 |
| Chen, YJ | 1 |
| Xiong, LL | 1 |
| Wang, TH | 1 |
| Xu, H | 1 |
| Zhang, S | 1 |
| Xie, J | 1 |
| Lei, Y | 1 |
| Cao, G | 1 |
| Pei, F | 1 |
| Pang, W | 1 |
| Liu, YC | 2 |
| Maboudou, E | 1 |
| Chen, TX | 1 |
| Chois, JM | 1 |
| Liao, CC | 1 |
| Wu, RS | 1 |
| Basaran, B | 1 |
| Basaran, A | 1 |
| Kozanhan, B | 1 |
| Kasdogan, E | 1 |
| Eryilmaz, MA | 1 |
| Ozmen, S | 1 |
| Alper, I | 1 |
| Ulukaya, S | 1 |
| Ertuğrul, V | 1 |
| Makay, O | 1 |
| Uyar, M | 1 |
| Balcioğlu, T | 1 |
| Lu, CW | 1 |
| Jean, WH | 1 |
| Wu, CC | 1 |
| Shieh, JS | 1 |
| Lin, TY | 1 |
| Miyagawa, Y | 1 |
| Ejiri, M | 1 |
| Kuzuya, T | 1 |
| Osada, T | 1 |
| Ishiguro, N | 1 |
| Yamada, K | 1 |
| Song, YK | 1 |
| Lee, C | 1 |
| Gronau, E | 1 |
| Pannek, J | 1 |
| Benninghoff, A | 1 |
| Seibold, W | 1 |
| Senge, T | 1 |
| Hirasawa, M | 1 |
| Hasegawa, J | 1 |
| Nishiyama, J | 1 |
| Suzuki, T | 1 |
| Inan, A | 1 |
| Sen, M | 1 |
| Dener, C | 1 |
| Ceyhan, A | 1 |
| Ustun, H | 1 |
| Altunatmaz, K | 1 |
| Ide, T | 1 |
| Unal, N | 1 |
| Chan, DC | 1 |
| Chen, CJ | 1 |
| Yu, JC | 1 |
| Chu, HC | 1 |
| Chen, FC | 1 |
| Chen, TW | 1 |
| Hsieh, HF | 1 |
| Chang, TM | 1 |
| Shen, KL | 1 |
| Antonetti, M | 1 |
| Kirton, O | 1 |
| Bui, P | 1 |
| Ademi, A | 1 |
| Staff, I | 1 |
| Hudson-Civetta, JA | 1 |
| Lilly, R | 1 |
| Reza, N | 1 |
| Ali, SM | 1 |
| Saeed, K | 1 |
| Abul-Qasim, A | 1 |
| Reza, TH | 1 |
| Mori, T | 1 |
| McKenzie, R | 1 |
| Tantisira, B | 1 |
| Jackson, D | 1 |
| Bach, T | 1 |
| Riley, T | 1 |
| Sims, C | 1 |
| Johnson, CM | 1 |
| Bergesio, R | 1 |
| Delfos, SJ | 1 |
| Avraamides, EA | 1 |
| Lisander, B | 2 |
| Kandler, D | 1 |
| MacCumber, MW | 1 |
| Jaffe, GJ | 1 |
| McCuen, BW | 1 |
| Chen, PP | 1 |
| Chui, PT | 1 |
| Gin, T | 1 |
| Pitkänen, MT | 1 |
| Numminen, MK | 1 |
| Tuominen, MK | 1 |
| Rosenberg, PH | 1 |
| Chung, F | 1 |
| Lane, R | 1 |
| Spraggs, C | 1 |
| McQuade, B | 1 |
| Jacka, M | 1 |
| Luttropp, HH | 1 |
| Alahuta, S | 1 |
| Rocherieux, S | 1 |
| Roy, M | 1 |
| Duvaldestin, P | 1 |
| Curtis, P | 1 |
| Krenn, H | 1 |
| Jellinek, H | 1 |
| Haumer, H | 1 |
| Oczenski, W | 1 |
| Fitzgerald, R | 1 |
| Sasaki, S | 1 |
| Okuyama, A | 1 |
| Ideuchi, N | 1 |
| Morimoto, Y | 1 |
| Kemmotsu, O | 1 |
| Hirayama, T | 1 |
| Ishii, F | 1 |
| Yago, K | 1 |
| Ogata, H | 1 |
| Piper, SN | 1 |
| Triem, JG | 1 |
| Maleck, WH | 1 |
| Fent, MT | 1 |
| Hüttner, I | 1 |
| Boldt, J | 1 |
| Tzeng, JI | 1 |
| Hsing, CH | 1 |
| Chu, CC | 1 |
| Chen, YH | 1 |
| Wang, JJ | 1 |
| Gibbs, RD | 1 |
| Movinsky, BA | 1 |
| Pellegrini, J | 1 |
| Vacchiano, CA | 1 |
| Quaynor, H | 1 |
| Raeder, JC | 1 |
| Jokela, R | 1 |
| Koivuranta, M | 1 |
| Kangas-Saarela, T | 1 |
| Purhonen, S | 1 |
| Alahuhta, S | 1 |
| Roberts, RH | 1 |
| Tan, ST | 1 |
| Sinclair, SW | 1 |
| Treen, DC | 1 |
| Downes, TW | 1 |
| Hayes, DH | 1 |
| McKinnon, WM | 1 |
| McGlew, IC | 1 |
| Angliss, DB | 1 |
| Gee, GJ | 1 |
| Rutherford, A | 1 |
| Wood, AT | 1 |
| Manara, AR | 1 |
| Shelly, MP | 1 |
| Quinn, K | 1 |
| Park, GR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Repeat Dose Steroid to Prevent Pain Relapse After Total Knee Arthroplasty in Patients With High Pain Response - A Randomized Double-blind Placebo-controlled Trial[NCT05563155] | Phase 4 | 110 participants (Anticipated) | Interventional | 2021-11-01 | Recruiting | ||
| Methylprednisolone Taper to Treat Delayed Post-Operative Recovery After Total Knee Arthroplasty: a Double-Blind Randomized Controlled Trial[NCT05113901] | Phase 4 | 4 participants (Actual) | Interventional | 2022-03-03 | Terminated (stopped due to Extremely low participation, decided to focus on similar study instead) | ||
| Steroid Administration for Articular Fractures of the Elbow (SAFE Trial): A Randomized, Controlled Trial of Perioperative Glucocorticoids During Treatment of Intraarticular Elbow Fractures[NCT04738318] | Phase 4 | 3 participants (Actual) | Interventional | 2022-06-16 | Terminated (stopped due to Switched to observational study type.) | ||
| The Effect of Ultrasound-Guided Erector Spinae Block on Respiratory Function After Laparoscopic Cholecystectomy[NCT03815799] | 68 participants (Actual) | Interventional | 2019-03-03 | Completed | |||
| Postoperative Efficacy of Subcostal TAP Block in Laparoscopic Sleeve Gastrectomy Surgery: a Randomized Controlled Trial[NCT06156657] | 100 participants (Anticipated) | Interventional | 2023-01-30 | Recruiting | |||
| Evaluation of Postoperative Analgesic Effect of Ultrasound Guided Erector Spinae Plane Block and Subcostal Transverse Abdominis Plane Block in Laparoscopic Cholecystectomy, Randomised Controlled Study[NCT04116008] | 70 participants (Actual) | Interventional | 2019-11-10 | Completed | |||
| Evaluation of Postoperative Analgesic Effect of Ultrasound Guided Erector Spinae Plane Block and Oblique Subcostal Transverse Abdominis Plane Block in Laparoscopic Cholecystectomy, Randomised Controlled Study[NCT03508531] | 60 participants (Actual) | Interventional | 2018-03-23 | Completed | |||
| A Prospective Evaluation of an Anesthesia Protocol to Reduce Post-operative and Post-discharge Nausea and Vomiting in a High Risk Orthognathic Surgery Population[NCT01592708] | 233 participants (Actual) | Interventional | 2012-06-30 | Completed | |||
| Do Peri-operative High Doses of Intravenous Glucocorticoids Improve Short-term Functional Outcome After Direct Anterior Total Hip Arthroplasty? A Randomized, Single Surgeon, Placebo Controlled, Double Blind Study[NCT04317872] | 70 participants (Anticipated) | Interventional | 2020-07-01 | Recruiting | |||
| The Effect of Turkish Classical Music on Postpartum Pain and Anxiety in Women Who Delivered Via Cesarean Section[NCT04111575] | 126 participants (Actual) | Interventional | 2018-02-05 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Adverse outcomes including infection, avascular necrosis, and 90-day readmission rates (NCT05113901)
Timeframe: within 90 days after initial total knee arthroplasty
| Intervention | Participants (Count of Participants) |
|---|---|
| Methylprednisolone Taper | 0 |
| Placebo Taper | 0 |
Manipulations under anesthesia (MUAs) following total knee arthroplasty surgery and treatment (NCT05113901)
Timeframe: within 90 days after initial total knee arthroplasty
| Intervention | Participants (Count of Participants) |
|---|---|
| Methylprednisolone Taper | 0 |
| Placebo Taper | 0 |
Single Assessment Numeric Evaluation (SANE), a single-question patient rating of 0-100, scoring their function to the area being treated. Zero represents a poor functional knee and 100 is the best functioning. (NCT05113901)
Timeframe: 6 weeks after treatment
| Intervention | score on a scale (Mean) |
|---|---|
| Methylprednisolone Taper | 89.5 |
UCLA activity score, on a scale of 1 to 10 where 10 is the most active patient with examples of activities (NCT05113901)
Timeframe: 6 weeks after treatment
| Intervention | score on a scale (Mean) |
|---|---|
| Methylprednisolone Taper | 5.25 |
VR-12: Assesses physical functioning, physical/ mental limitations. Scored as summary of mental and physical, measure in standard deviations. The scale range is 0 to 100, where a score of 100 represents the best physical and mental health and zero is the worst outcome. (NCT05113901)
Timeframe: 6 weeks after treatment
| Intervention | score on a scale (Mean) |
|---|---|
| Methylprednisolone Taper | 50.28 |
Forgotten Joint Score (FJS) is a survey scored ranging from 0 to 100, where a high score indicates a high degree of a forgetting they have an artificial joint, which is an ideal outcome. (NCT05113901)
Timeframe: 6 weeks after treatment
| Intervention | score on a scale (Mean) |
|---|---|
| Methylprednisolone Taper | 57.82 |
Knee Injury and Osteoarthritis Outcome Score for Joint Replacement (KOOS JR), a survey given to patients standard of care containing 7 questions. The score ranges from 0 to 100 where zero represents total disability and 100 represents a perfect knee health. (NCT05113901)
Timeframe: 6 weeks after treatment
| Intervention | score on a scale (Mean) |
|---|---|
| Methylprednisolone Taper | 72.12 |
Knee Injury and Osteoarthritis Outcome Score for Joint Replacement (KOOS JR), a survey given to patients standard of care containing 7 questions. The score ranges from 0 to 100 where zero represents total disability and 100 represents a perfect knee health. (NCT05113901)
Timeframe: pre treatment
| Intervention | score on a scale (Mean) |
|---|---|
| Methylprednisolone Taper | 50.04 |
Single Assessment Numeric Evaluation (SANE), a single-question patient rating of 0-100, scoring their function to the area being treated. Zero represents a poor functional knee and 100 is the best functioning. (NCT05113901)
Timeframe: pre treatment
| Intervention | score on a scale (Mean) |
|---|---|
| Methylprednisolone Taper | 29.5 |
Veterans Rand 12-Item Health Survey (VR-12), a survey of 12 questions to measure health relating to patient's quality of life. Scored as summary of mental and physical, measure in standard deviations. The scale range is 0 to 100, where a score of 100 represents the best physical and mental health and zero is the worst outcome. (NCT05113901)
Timeframe: pre treatment
| Intervention | score on a scale (Mean) |
|---|---|
| Methylprednisolone Taper | 38.73 |
Forgotten Joint Score (FJS) is a survey scored ranging from 0 to 100, where a high score indicates a high degree of a forgetting they have an artificial joint, which is an ideal outcome. (NCT05113901)
Timeframe: pre treatment
| Intervention | score on a scale (Mean) |
|---|---|
| Methylprednisolone Taper | 91.67 |
UCLA activity score, on a scale of 1 to 10 where 10 is the most active patient with examples of activities (NCT05113901)
Timeframe: pre treatment
| Intervention | score on a scale (Mean) |
|---|---|
| Methylprednisolone Taper | 4.25 |
"Knee society score (KSS); done standard of care on a scale of 0-100, where 100 means a more functional knee.~**Please note, the study was terminated early, only 4 subjects were enrolled and none were randomized to the placebo group. At 3 weeks post treatment, only 3 of the 4 subjects enrolled were still part of the study." (NCT05113901)
Timeframe: 3 weeks post treatment
| Intervention | score on a scale (Mean) |
|---|---|
| Methylprednisolone Taper | 68.33 |
"Knee society score (KSS); done standard of care on a scale of 0-100, where 100 means a more functional knee.~**Please note, the study was terminated early, only 4 subjects were enrolled and none were randomized to the placebo group. This is a standard of care survey available on all subjects." (NCT05113901)
Timeframe: 6 weeks post treatment
| Intervention | score on a scale (Mean) |
|---|---|
| Methylprednisolone Taper | 78.75 |
"Using daily defense and veterans pain rating scale (DVPRS) on a scale of 1 to 10, 10 being the worst.~Please note, only one patient made it to the 6 week post treatment mark of the 4 enrolled. The study was terminated and none of the patients were randomized to the placebo group. All other patients followed up but were not interested in continuing. No range could be provided given only one subject answered and completed this visit" (NCT05113901)
Timeframe: 6 weeks post treatment
| Intervention | score on a scale (Mean) |
|---|---|
| Methylprednisolone Taper | 1.93 |
"Knee society score (KSS); done standard of care on a scale of 0-100, where 100 means a more functional knee~**Please note, the study was terminated early, only 4 subjects were enrolled and none were randomized to the placebo group." (NCT05113901)
Timeframe: pre treatment
| Intervention | score on a scale (Mean) |
|---|---|
| Methylprednisolone Taper | 66.25 |
"Using Daily Visual Analogue Scale (VAS) pain score, which measures intensity of pain on a scale of 0 (no pain) to 10 (worst pain possible).~**Please note, this study was terminated early, only enrolling 4 patients, none were randomized to the placebo group." (NCT05113901)
Timeframe: Days 1 through 6 following treatment
| Intervention | score on a scale (Mean) | |||||
|---|---|---|---|---|---|---|
| Day 1 | Day 2 | Day 3 | Day 4 | Day 5 | Day 6 | |
| Methylprednisolone Taper | 2.33 | 3 | 1.33 | 1.33 | 1.67 | 2.3 |
"Range of motion (ROM) from pre-treatment to six weeks following treatment. Patients started treatment after total knee replacement surgery and presented to clinic with at least one inclusion criteria to be enrolled. Range of motion in degrees is taken at each visit by a clinician (standard of care), starting at zero degrees (straight leg) to about 135 degrees. The ROM was documented as part of consenting and enrollment into study. Subjects returned to the office at 6 weeks post treatment where ROM was performed in a clinic setting once again and documented. ROM is done using a goniometer by a clinician in each clinic.~This study was terminated early, therefore of the 4 enrolled, zero were randomized to the placebo group. Only 1 of the four subjects completed the 6 weeks, however, ROM was captured on all as standard of care." (NCT05113901)
Timeframe: Baseline, Week 6 Following Treatment
| Intervention | Range of Motion in Degrees (Mean) | |
|---|---|---|
| Pre treatment | Post treatment | |
| Methylprednisolone Taper | 82.5 | 112 |
Anesthesia start time determined from anesthesia portion of the medical record. Time at which discharge order was placed will serve as time of discharge. (NCT01592708)
Timeframe: Anesthesia start time to placement of hospital discharge order - average 26 - 28 hours
| Intervention | hours (Median) |
|---|---|
| Intervention Cohort | 26.4 |
| Comparison Cohort | 28.2 |
To be assessed based on patient diary completed daily for 1 week following discharge to home from the hospital (NCT01592708)
Timeframe: 1 week from discharge from hospital
| Intervention | percentage of subjects with PDN (Number) |
|---|---|
| Intervention Cohort | 72 |
| Comparison Cohort | 60 |
(NCT01592708)
Timeframe: 1 week post discharge
| Intervention | percentage of subjects with PDV (Number) |
|---|---|
| Intervention Cohort | 22 |
| Comparison Cohort | 29 |
End of surgery time determined by anesthesia portion of the medical record. PONV to be assessed by review of surgeons' and nurses' notes in the medical record as well as through review of patient diaries. Vomiting constitutes a safety issue and, as such, associated adverse events will be noted. (NCT01592708)
Timeframe: End of surgery to discharge from hospital
| Intervention | percentage of subjects with PON (Number) |
|---|---|
| Intervention Cohort | 24 |
| Comparison Cohort | 70 |
(NCT01592708)
Timeframe: End of surgery to discharge from hospital
| Intervention | percentage of subjects with POV (Number) |
|---|---|
| Intervention Cohort | 11 |
| Comparison Cohort | 28 |
1 review available for metoclopramide and Pain, Postoperative
| Article | Year |
|---|---|
Evaluation of the effective drugs for the prevention of nausea and vomiting induced by morphine used for postoperative pain: a quantitative systematic review.
Topics: Antiemetics; Dexamethasone; Droperidol; Humans; Metoclopramide; Morphine; Ondansetron; Pain, Postope | 2001 |
26 trials available for metoclopramide and Pain, Postoperative
| Article | Year |
|---|---|
Multiple Doses of Perioperative Dexamethasone Further Improve Clinical Outcomes After Total Knee Arthroplasty: A Prospective, Randomized, Controlled Study.
Topics: Aged; Analgesics; Antiemetics; Arthroplasty, Replacement, Knee; Blood Glucose; C-Reactive Protein; D | 2018 |
Multiple Doses of Perioperative Dexamethasone Further Improve Clinical Outcomes After Total Knee Arthroplasty: A Prospective, Randomized, Controlled Study.
Topics: Aged; Analgesics; Antiemetics; Arthroplasty, Replacement, Knee; Blood Glucose; C-Reactive Protein; D | 2018 |
Multiple Doses of Perioperative Dexamethasone Further Improve Clinical Outcomes After Total Knee Arthroplasty: A Prospective, Randomized, Controlled Study.
Topics: Aged; Analgesics; Antiemetics; Arthroplasty, Replacement, Knee; Blood Glucose; C-Reactive Protein; D | 2018 |
Multiple Doses of Perioperative Dexamethasone Further Improve Clinical Outcomes After Total Knee Arthroplasty: A Prospective, Randomized, Controlled Study.
Topics: Aged; Analgesics; Antiemetics; Arthroplasty, Replacement, Knee; Blood Glucose; C-Reactive Protein; D | 2018 |
Multiple Doses of Perioperative Dexamethasone Further Improve Clinical Outcomes After Total Knee Arthroplasty: A Prospective, Randomized, Controlled Study.
Topics: Aged; Analgesics; Antiemetics; Arthroplasty, Replacement, Knee; Blood Glucose; C-Reactive Protein; D | 2018 |
Multiple Doses of Perioperative Dexamethasone Further Improve Clinical Outcomes After Total Knee Arthroplasty: A Prospective, Randomized, Controlled Study.
Topics: Aged; Analgesics; Antiemetics; Arthroplasty, Replacement, Knee; Blood Glucose; C-Reactive Protein; D | 2018 |
Multiple Doses of Perioperative Dexamethasone Further Improve Clinical Outcomes After Total Knee Arthroplasty: A Prospective, Randomized, Controlled Study.
Topics: Aged; Analgesics; Antiemetics; Arthroplasty, Replacement, Knee; Blood Glucose; C-Reactive Protein; D | 2018 |
Multiple Doses of Perioperative Dexamethasone Further Improve Clinical Outcomes After Total Knee Arthroplasty: A Prospective, Randomized, Controlled Study.
Topics: Aged; Analgesics; Antiemetics; Arthroplasty, Replacement, Knee; Blood Glucose; C-Reactive Protein; D | 2018 |
Multiple Doses of Perioperative Dexamethasone Further Improve Clinical Outcomes After Total Knee Arthroplasty: A Prospective, Randomized, Controlled Study.
Topics: Aged; Analgesics; Antiemetics; Arthroplasty, Replacement, Knee; Blood Glucose; C-Reactive Protein; D | 2018 |
Metoclopramide improves the quality of tramadol PCA indistinguishable to morphine PCA: a prospective, randomized, double blind clinical comparison.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics; Antiemetics; Arthroplasty, Replacement, Knee; Doubl | 2013 |
Analgesia and respiratory function after laparoscopic cholecystectomy in patients receiving ultrasound-guided bilateral oblique subcostal transversus abdominis plane block: a randomized double-blind study.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; C | 2015 |
Analgesia and respiratory function after laparoscopic cholecystectomy in patients receiving ultrasound-guided bilateral oblique subcostal transversus abdominis plane block: a randomized double-blind study.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; C | 2015 |
Analgesia and respiratory function after laparoscopic cholecystectomy in patients receiving ultrasound-guided bilateral oblique subcostal transversus abdominis plane block: a randomized double-blind study.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; C | 2015 |
Analgesia and respiratory function after laparoscopic cholecystectomy in patients receiving ultrasound-guided bilateral oblique subcostal transversus abdominis plane block: a randomized double-blind study.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; C | 2015 |
Analgesia and respiratory function after laparoscopic cholecystectomy in patients receiving ultrasound-guided bilateral oblique subcostal transversus abdominis plane block: a randomized double-blind study.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; C | 2015 |
Analgesia and respiratory function after laparoscopic cholecystectomy in patients receiving ultrasound-guided bilateral oblique subcostal transversus abdominis plane block: a randomized double-blind study.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; C | 2015 |
Analgesia and respiratory function after laparoscopic cholecystectomy in patients receiving ultrasound-guided bilateral oblique subcostal transversus abdominis plane block: a randomized double-blind study.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; C | 2015 |
Analgesia and respiratory function after laparoscopic cholecystectomy in patients receiving ultrasound-guided bilateral oblique subcostal transversus abdominis plane block: a randomized double-blind study.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; C | 2015 |
Analgesia and respiratory function after laparoscopic cholecystectomy in patients receiving ultrasound-guided bilateral oblique subcostal transversus abdominis plane block: a randomized double-blind study.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; C | 2015 |
Analgesia and respiratory function after laparoscopic cholecystectomy in patients receiving ultrasound-guided bilateral oblique subcostal transversus abdominis plane block: a randomized double-blind study.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; C | 2015 |
Analgesia and respiratory function after laparoscopic cholecystectomy in patients receiving ultrasound-guided bilateral oblique subcostal transversus abdominis plane block: a randomized double-blind study.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; C | 2015 |
Analgesia and respiratory function after laparoscopic cholecystectomy in patients receiving ultrasound-guided bilateral oblique subcostal transversus abdominis plane block: a randomized double-blind study.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; C | 2015 |
Analgesia and respiratory function after laparoscopic cholecystectomy in patients receiving ultrasound-guided bilateral oblique subcostal transversus abdominis plane block: a randomized double-blind study.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; C | 2015 |
Analgesia and respiratory function after laparoscopic cholecystectomy in patients receiving ultrasound-guided bilateral oblique subcostal transversus abdominis plane block: a randomized double-blind study.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; C | 2015 |
Analgesia and respiratory function after laparoscopic cholecystectomy in patients receiving ultrasound-guided bilateral oblique subcostal transversus abdominis plane block: a randomized double-blind study.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; C | 2015 |
Analgesia and respiratory function after laparoscopic cholecystectomy in patients receiving ultrasound-guided bilateral oblique subcostal transversus abdominis plane block: a randomized double-blind study.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; C | 2015 |
Effects of intraperitoneal levobupivacaine on pain after laparoscopic cholecystectomy: a prospective, randomized, double-blinded study.
Topics: Adult; Anesthetics, Local; Bupivacaine; Cholecystectomy; Double-Blind Method; Female; Humans; Laparo | 2009 |
Antiemetic efficacy of metoclopramide and diphenhydramine added to patient-controlled morphine analgesia: a randomised controlled trial.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Antiemetics; Dexamethasone; Diphenhydramin | 2010 |
Effects of ramosetron and dexamethasone on postoperative nausea, vomiting, pain, and shivering in female patients undergoing thyroid surgery.
Topics: Adult; Aged; Anesthesia, General; Antiemetics; Benzimidazoles; Dexamethasone; Female; Humans; Metocl | 2013 |
[Postoperative pain therapy in urology. A prospective study].
Topics: Analgesia, Patient-Controlled; Dipyrone; Dose-Response Relationship, Drug; Drug Administration Sched | 2002 |
Preventing prolonged post-operative ileus in gastric cancer patients undergoing gastrectomy and intra-peritoneal chemotherapy.
Topics: Adult; Aged; Dopamine Antagonists; Electrolytes; Female; Gastrectomy; Humans; Ileus; Male; Metoclopr | 2005 |
The effects of preoperative rofecoxib, metoclopramide, dexamethasone, and ondansetron on postoperative pain and nausea in patients undergoing elective laparoscopic cholecystectomy.
Topics: Antiemetics; Cholecystectomy, Laparoscopic; Cyclooxygenase 2 Inhibitors; Dexamethasone; Double-Blind | 2007 |
The impact of music on postoperative pain and anxiety following cesarean section.
Topics: Adult; Analgesics, Opioid; Anesthesia, General; Anti-Anxiety Agents; Antiemetics; Anxiety; Cesarean | 2007 |
Antiemetic efficacy of a droperidol-morphine combination in patient-controlled analgesia.
Topics: Adolescent; Adult; Analgesia, Patient-Controlled; Dose-Response Relationship, Drug; Double-Blind Met | 1995 |
Rectal indomethacin for analgesia after appendicectomy in children.
Topics: Administration, Rectal; Analgesia; Analgesia, Patient-Controlled; Appendectomy; Child; Double-Blind | 1994 |
Evaluation of the analgesic effect of metoclopramide after opioid-free analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Anesthesia, General; Arthroscopy; Double-Blind Met | 1993 |
Analgesic action of metoclopramide in prosthetic hip surgery.
Topics: Aged; Anesthesia, Spinal; Bupivacaine; Double-Blind Method; Female; Hip Prosthesis; Humans; Infusion | 1993 |
Comparison of ondansetron and metoclopramide for the prevention of post-operative nausea and vomiting after major gynaecological surgery.
Topics: Adolescent; Adult; Analgesics, Opioid; Antiemetics; Double-Blind Method; Female; Humans; Hysterectom | 1996 |
Comparison of metoclopramide and ondansetron for the prevention of nausea and vomiting after intrathecal morphine.
Topics: Aged; Analgesics, Opioid; Antiemetics; Blood Pressure; Double-Blind Method; Female; Hip; Humans; Inj | 1997 |
Ondansetron is more effective than metoclopramide for the treatment of opioid-induced emesis in post-surgical adult patients. Ondansetron OIE Post-Surgical Study Group.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Antiemetics; Double-Blind Method; Fe | 1999 |
Placebo-controlled comparison of dolasetron and metoclopramide in preventing postoperative nausea and vomiting in patients undergoing hysterectomy.
Topics: Antiemetics; Blood Loss, Surgical; Droperidol; Female; Humans; Hysterectomy; Indoles; Metoclopramide | 2001 |
Low-dose dexamethasone reduces nausea and vomiting after epidural morphine: a comparison of metoclopramide with saline.
Topics: Adult; Analgesia, Epidural; Analgesics, Opioid; Antiemetics; Dexamethasone; Double-Blind Method; Fem | 2002 |
The morphine-sparing effect of metoclopramide on postoperative laparoscopic tubal ligation patients.
Topics: Adult; Analgesics, Opioid; Dopamine Antagonists; Double-Blind Method; Female; Humans; Laparoscopy; M | 2002 |
Incidence and severity of postoperative nausea and vomiting are similar after metoclopramide 20 mg and ondansetron 8 mg given by the end of laparoscopic cholecystectomies.
Topics: Anesthesia, General; Antiemetics; Cholecystectomy, Laparoscopic; Double-Blind Method; Female; Humans | 2002 |
Oral ondansetron, tropisetron or metoclopramide to prevent postoperative nausea and vomiting: a comparison in high-risk patients undergoing thyroid or parathyroid surgery.
Topics: Adult; Analgesics, Opioid; Antiemetics; Double-Blind Method; Female; Humans; Indoles; Male; Metoclop | 2002 |
Lignocaine vs bupivacaine in prominent ear correction: a controlled trial.
Topics: Acetaminophen; Adolescent; Adult; Anesthesia, General; Anesthesia, Local; Bupivacaine; Child; Child, | 1992 |
Outpatient cholecystectomy simulated in an inpatient population.
Topics: Abdomen; Adult; Age Factors; Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Analgesics; An | 1991 |
A comparison of rectal indomethacin with placebo for pain relief following spinal surgery.
Topics: Administration, Rectal; Bleeding Time; Blood Loss, Surgical; Diazepam; Double-Blind Method; Drinking | 1991 |
The effect of metoclopramide on the absorption of oral controlled release morphine.
Topics: Administration, Oral; Aged; Delayed-Action Preparations; Double-Blind Method; Drug Interactions; Fem | 1988 |
9 other studies available for metoclopramide and Pain, Postoperative
| Article | Year |
|---|---|
Analgesic effects of sufentanil in combination with flurbiprofen axetil and dexmedetomidine after open gastrointestinal tumor surgery: a retrospective study.
Topics: Analgesics; Analgesics, Opioid; Dexmedetomidine; Flurbiprofen; Gastrointestinal Neoplasms; Humans; M | 2022 |
Methylprednisolone reduces postoperative nausea in total knee and hip arthroplasty.
Topics: Adult; Aged; Aged, 80 and over; Antiemetics; Arthroplasty, Replacement, Hip; Arthroplasty, Replaceme | 2010 |
Utilization of PCIA (patient-controlled intravenous analgesia) for postoperative analgesia of spine fusion.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Antiemetics; Female; Humans; Injections, In | 2003 |
Local anesthesia use for laparoscopic cholecystectomy.
Topics: Adult; Aged; Analgesics; Anesthesia, Local; Antiemetics; Bupivacaine; Cholecystectomy, Laparoscopic; | 2004 |
Is metoclopramide an alternative to tramadol in management of post-operative pain? An experimental study.
Topics: Analgesics, Opioid; Animals; Dopamine Antagonists; Male; Metoclopramide; Pain Measurement; Pain, Pos | 2005 |
[Studies on changes of the plasma prolactin, growth hormone and ACTH levels following surgical stress and epidural micro-injections of morphine hydrochloride as a postoperative analgesic method].
Topics: Adrenocorticotropic Hormone; Adult; Analgesia; Epidural Space; Growth Hormone; Humans; Metoclopramid | 1982 |
Treatment of migraine headache after ocular surgery with intravenous metoclopramide hydrochloride.
Topics: Adult; Cataract Extraction; Dopamine Antagonists; Female; Humans; Injections, Intravenous; Lenses, I | 1996 |
Naloxone-resistant respiratory depression and neurological eye symptoms after intrathecal morphine.
Topics: Aged; Analgesics, Opioid; Antiemetics; Depression, Chemical; Drug Interactions; Drug Resistance; Eye | 2000 |
[Propofol anesthesia for ambulatory surgery in adults].
Topics: Adult; Ambulatory Surgical Procedures; Anesthesia, General; Anesthesia, Local; Fentanyl; Flurbiprofe | 2000 |