Page last updated: 2024-10-31

metoclopramide and Pain, Postoperative

metoclopramide has been researched along with Pain, Postoperative in 36 studies

Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.
metoclopramide : A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.

Pain, Postoperative: Pain during the period after surgery.

Research Excerpts

ExcerptRelevanceReference
"Ondansetron has a well documented antiemetic prophylactic effect, whereas in most studies of postoperative nausea and vomiting (PONV), metoclopramide is less efficacious."9.10Incidence and severity of postoperative nausea and vomiting are similar after metoclopramide 20 mg and ondansetron 8 mg given by the end of laparoscopic cholecystectomies. ( Quaynor, H; Raeder, JC, 2002)
" Intravenous ondansetron and tropisetron prevent postoperative nausea and vomiting (PONV) at least as efficiently as traditional antiemetics, droperidol and metoclopramide."9.10Oral ondansetron, tropisetron or metoclopramide to prevent postoperative nausea and vomiting: a comparison in high-risk patients undergoing thyroid or parathyroid surgery. ( Alahuhta, S; Jokela, R; Kangas-Saarela, T; Koivuranta, M; Purhonen, S, 2002)
") doses of ondansetron 8 mg, ondansetron 16 mg and metoclopramide 10 mg in the treatment of opioid-induced emesis."9.09Ondansetron is more effective than metoclopramide for the treatment of opioid-induced emesis in post-surgical adult patients. Ondansetron OIE Post-Surgical Study Group. ( Alahuta, S; Chung, F; Curtis, P; Duvaldestin, P; Jacka, M; Lane, R; Luttropp, HH; McQuade, B; Rocherieux, S; Roy, M; Spraggs, C, 1999)
"Dolasetron reduced the postoperative nausea and vomiting score significantly (P < 0."9.09Placebo-controlled comparison of dolasetron and metoclopramide in preventing postoperative nausea and vomiting in patients undergoing hysterectomy. ( Boldt, J; Fent, MT; Hüttner, I; Maleck, WH; Piper, SN; Triem, JG, 2001)
"The efficacy of ondansetron 4 mg was compared with metoclopramide 10 mg for the prevention of post-operative nausea and vomiting in patients after major gynaecological abdominal surgery."9.08Comparison of ondansetron and metoclopramide for the prevention of post-operative nausea and vomiting after major gynaecological surgery. ( Chen, PP; Chui, PT; Gin, T, 1996)
" Incidences of postoperative nausea and vomiting, number of patients requiring antiemetic rescue, and overall consumption of metoclopramide were lower in groups B and C than in group A (all P < ."5.27Multiple Doses of Perioperative Dexamethasone Further Improve Clinical Outcomes After Total Knee Arthroplasty: A Prospective, Randomized, Controlled Study. ( Cao, G; Lei, Y; Pei, F; Xie, J; Xu, H; Zhang, S, 2018)
"the objective of this study was to assess whether antiemetic drugs metoclopramide and diphenhydramine, administered together as opposed to alone, can have better efficacy in preventing postoperative nausea and vomiting when added to patient-controlled morphine analgesia."5.14Antiemetic efficacy of metoclopramide and diphenhydramine added to patient-controlled morphine analgesia: a randomised controlled trial. ( Jean, WH; Lin, TY; Lu, CW; Shieh, JS; Wu, CC, 2010)
" In addition postoperative morphine requirement, anxiety, and vomiting were not affected by the music during general anesthesia."5.12The impact of music on postoperative pain and anxiety following cesarean section. ( Abul-Qasim, A; Ali, SM; Reza, N; Reza, TH; Saeed, K, 2007)
"To assess the efficacy of metoclopramide (Met) for prevention of prolonged post-operative ileus in advanced gastric cancer patients undergoing D2 gastrectomy and intra-peritoneal chemotherapy (IPC)."5.11Preventing prolonged post-operative ileus in gastric cancer patients undergoing gastrectomy and intra-peritoneal chemotherapy. ( Chan, DC; Chang, TM; Chen, CJ; Chen, FC; Chen, TW; Chu, HC; Hsieh, HF; Liu, YC; Shen, KL; Yu, JC, 2005)
"Ondansetron has a well documented antiemetic prophylactic effect, whereas in most studies of postoperative nausea and vomiting (PONV), metoclopramide is less efficacious."5.10Incidence and severity of postoperative nausea and vomiting are similar after metoclopramide 20 mg and ondansetron 8 mg given by the end of laparoscopic cholecystectomies. ( Quaynor, H; Raeder, JC, 2002)
" Intravenous ondansetron and tropisetron prevent postoperative nausea and vomiting (PONV) at least as efficiently as traditional antiemetics, droperidol and metoclopramide."5.10Oral ondansetron, tropisetron or metoclopramide to prevent postoperative nausea and vomiting: a comparison in high-risk patients undergoing thyroid or parathyroid surgery. ( Alahuhta, S; Jokela, R; Kangas-Saarela, T; Koivuranta, M; Purhonen, S, 2002)
") doses of ondansetron 8 mg, ondansetron 16 mg and metoclopramide 10 mg in the treatment of opioid-induced emesis."5.09Ondansetron is more effective than metoclopramide for the treatment of opioid-induced emesis in post-surgical adult patients. Ondansetron OIE Post-Surgical Study Group. ( Alahuta, S; Chung, F; Curtis, P; Duvaldestin, P; Jacka, M; Lane, R; Luttropp, HH; McQuade, B; Rocherieux, S; Roy, M; Spraggs, C, 1999)
"Dolasetron reduced the postoperative nausea and vomiting score significantly (P < 0."5.09Placebo-controlled comparison of dolasetron and metoclopramide in preventing postoperative nausea and vomiting in patients undergoing hysterectomy. ( Boldt, J; Fent, MT; Hüttner, I; Maleck, WH; Piper, SN; Triem, JG, 2001)
"The efficacy of ondansetron 4 mg was compared with metoclopramide 10 mg for the prevention of post-operative nausea and vomiting in patients after major gynaecological abdominal surgery."5.08Comparison of ondansetron and metoclopramide for the prevention of post-operative nausea and vomiting after major gynaecological surgery. ( Chen, PP; Chui, PT; Gin, T, 1996)
"Postoperative nausea and vomiting (PONV) with morphine therapy develops in more than 60% of patients after surgery, markedly reducing patient QOL."4.81Evaluation of the effective drugs for the prevention of nausea and vomiting induced by morphine used for postoperative pain: a quantitative systematic review. ( Hirayama, T; Ishii, F; Ogata, H; Yago, K, 2001)
"In total knee and hip arthroplasty, methylprednisolone is effective in preventing postoperative nausea; however, higher doses of methylprednisolone may be needed to prevent vomiting."3.76Methylprednisolone reduces postoperative nausea in total knee and hip arthroplasty. ( Ejiri, M; Ishiguro, N; Kuzuya, T; Miyagawa, Y; Osada, T; Yamada, K, 2010)
"As metoclopramide is an antiemetic and an analgesic, it was hypothesized that when added to reduce PONV, metoclopromide may enhance the multimodal feature of tramadol by the analgesic property of metoclopramide."2.78Metoclopramide improves the quality of tramadol PCA indistinguishable to morphine PCA: a prospective, randomized, double blind clinical comparison. ( Chen, TX; Chois, JM; Liao, CC; Liu, YC; Maboudou, E; Pang, W; Wu, RS, 2013)
"The overall incidence and severity of postoperative nausea and the level of antiemetic consumption were significantly lower in group R compared with group D, and these parameters were significantly lower in groups R and D than in group C."2.78Effects of ramosetron and dexamethasone on postoperative nausea, vomiting, pain, and shivering in female patients undergoing thyroid surgery. ( Lee, C; Song, YK, 2013)
"Data of intraoperative variables, postoperative pain relief, rescue analgesic consumption, side effects, and patient satisfaction were followed in both groups."2.74Effects of intraperitoneal levobupivacaine on pain after laparoscopic cholecystectomy: a prospective, randomized, double-blinded study. ( Alper, I; Balcioğlu, T; Ertuğrul, V; Makay, O; Ulukaya, S; Uyar, M, 2009)
"Thus, with combined analgesic treatment, postoperative pain relieve can be achieved safely and without additional costs."2.70[Postoperative pain therapy in urology. A prospective study]. ( Benninghoff, A; Gronau, E; Pannek, J; Seibold, W; Senge, T, 2002)
"Metoclopramide traditionally has been used as a prokinetic and antiemetic, but recently it also has been investigated as an agent to enhance analgesic efficacy."2.70The morphine-sparing effect of metoclopramide on postoperative laparoscopic tubal ligation patients. ( Gibbs, RD; Movinsky, BA; Pellegrini, J; Vacchiano, CA, 2002)
"An intermittent intake of low-dose droperidol with morphine given via a PCA delivery system in two treatment groups gave evidence for a dose-response relation between the amount of droperidol added and the proportion of patients needing a rescue antiemetic."2.68Antiemetic efficacy of a droperidol-morphine combination in patient-controlled analgesia. ( Bach, T; Jackson, D; McKenzie, R; Riley, T; Tantisira, B, 1995)
"Metoclopramide may enhance opioid analgesia, but it is not known if the drug is analgesic itself."2.67Evaluation of the analgesic effect of metoclopramide after opioid-free analgesia. ( Lisander, B, 1993)
"Metoclopramide-treated patients did not demonstrate a lower incidence of nausea or emesis but did tolerate oral liquids earlier after surgery than the placebo group (P less than 0."2.67Outpatient cholecystectomy simulated in an inpatient population. ( Downes, TW; Hayes, DH; McKinnon, WM; Treen, DC, 1991)
"The analgesic effects of PCIA with sufentanil in combination with flurbiprofen axetil and dexmedetomidine on postoperative analgesia was better than that of traditional pure opioids PCIA, and similar with that of PCEA."1.72Analgesic effects of sufentanil in combination with flurbiprofen axetil and dexmedetomidine after open gastrointestinal tumor surgery: a retrospective study. ( Chen, YJ; Huang, J; Li, TT; Liu, F; Wang, TH; Xiong, LL; Yin, L, 2022)
" Additionally, a 1 ml bolus dosage was administered at a 60-minute lockout interval employing a pump which contained 36 mg of morphine hydrochloride, 30 mg of metoclopramide hydrochloride in 62 ml of physiologic saline."1.32Utilization of PCIA (patient-controlled intravenous analgesia) for postoperative analgesia of spine fusion. ( Hasegawa, J; Hirasawa, M; Nishiyama, J; Suzuki, T, 2003)

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-19902 (5.56)18.7374
1990's11 (30.56)18.2507
2000's16 (44.44)29.6817
2010's6 (16.67)24.3611
2020's1 (2.78)2.80

Authors

AuthorsStudies
Liu, F1
Li, TT1
Yin, L1
Huang, J1
Chen, YJ1
Xiong, LL1
Wang, TH1
Xu, H1
Zhang, S1
Xie, J1
Lei, Y1
Cao, G1
Pei, F1
Pang, W1
Liu, YC2
Maboudou, E1
Chen, TX1
Chois, JM1
Liao, CC1
Wu, RS1
Basaran, B1
Basaran, A1
Kozanhan, B1
Kasdogan, E1
Eryilmaz, MA1
Ozmen, S1
Alper, I1
Ulukaya, S1
Ertuğrul, V1
Makay, O1
Uyar, M1
Balcioğlu, T1
Lu, CW1
Jean, WH1
Wu, CC1
Shieh, JS1
Lin, TY1
Miyagawa, Y1
Ejiri, M1
Kuzuya, T1
Osada, T1
Ishiguro, N1
Yamada, K1
Song, YK1
Lee, C1
Gronau, E1
Pannek, J1
Benninghoff, A1
Seibold, W1
Senge, T1
Hirasawa, M1
Hasegawa, J1
Nishiyama, J1
Suzuki, T1
Inan, A1
Sen, M1
Dener, C1
Ceyhan, A1
Ustun, H1
Altunatmaz, K1
Ide, T1
Unal, N1
Chan, DC1
Chen, CJ1
Yu, JC1
Chu, HC1
Chen, FC1
Chen, TW1
Hsieh, HF1
Chang, TM1
Shen, KL1
Antonetti, M1
Kirton, O1
Bui, P1
Ademi, A1
Staff, I1
Hudson-Civetta, JA1
Lilly, R1
Reza, N1
Ali, SM1
Saeed, K1
Abul-Qasim, A1
Reza, TH1
Mori, T1
McKenzie, R1
Tantisira, B1
Jackson, D1
Bach, T1
Riley, T1
Sims, C1
Johnson, CM1
Bergesio, R1
Delfos, SJ1
Avraamides, EA1
Lisander, B2
Kandler, D1
MacCumber, MW1
Jaffe, GJ1
McCuen, BW1
Chen, PP1
Chui, PT1
Gin, T1
Pitkänen, MT1
Numminen, MK1
Tuominen, MK1
Rosenberg, PH1
Chung, F1
Lane, R1
Spraggs, C1
McQuade, B1
Jacka, M1
Luttropp, HH1
Alahuta, S1
Rocherieux, S1
Roy, M1
Duvaldestin, P1
Curtis, P1
Krenn, H1
Jellinek, H1
Haumer, H1
Oczenski, W1
Fitzgerald, R1
Sasaki, S1
Okuyama, A1
Ideuchi, N1
Morimoto, Y1
Kemmotsu, O1
Hirayama, T1
Ishii, F1
Yago, K1
Ogata, H1
Piper, SN1
Triem, JG1
Maleck, WH1
Fent, MT1
Hüttner, I1
Boldt, J1
Tzeng, JI1
Hsing, CH1
Chu, CC1
Chen, YH1
Wang, JJ1
Gibbs, RD1
Movinsky, BA1
Pellegrini, J1
Vacchiano, CA1
Quaynor, H1
Raeder, JC1
Jokela, R1
Koivuranta, M1
Kangas-Saarela, T1
Purhonen, S1
Alahuhta, S1
Roberts, RH1
Tan, ST1
Sinclair, SW1
Treen, DC1
Downes, TW1
Hayes, DH1
McKinnon, WM1
McGlew, IC1
Angliss, DB1
Gee, GJ1
Rutherford, A1
Wood, AT1
Manara, AR1
Shelly, MP1
Quinn, K1
Park, GR1

Clinical Trials (10)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Repeat Dose Steroid to Prevent Pain Relapse After Total Knee Arthroplasty in Patients With High Pain Response - A Randomized Double-blind Placebo-controlled Trial[NCT05563155]Phase 4110 participants (Anticipated)Interventional2021-11-01Recruiting
Methylprednisolone Taper to Treat Delayed Post-Operative Recovery After Total Knee Arthroplasty: a Double-Blind Randomized Controlled Trial[NCT05113901]Phase 44 participants (Actual)Interventional2022-03-03Terminated (stopped due to Extremely low participation, decided to focus on similar study instead)
Steroid Administration for Articular Fractures of the Elbow (SAFE Trial): A Randomized, Controlled Trial of Perioperative Glucocorticoids During Treatment of Intraarticular Elbow Fractures[NCT04738318]Phase 43 participants (Actual)Interventional2022-06-16Terminated (stopped due to Switched to observational study type.)
The Effect of Ultrasound-Guided Erector Spinae Block on Respiratory Function After Laparoscopic Cholecystectomy[NCT03815799]68 participants (Actual)Interventional2019-03-03Completed
Postoperative Efficacy of Subcostal TAP Block in Laparoscopic Sleeve Gastrectomy Surgery: a Randomized Controlled Trial[NCT06156657]100 participants (Anticipated)Interventional2023-01-30Recruiting
Evaluation of Postoperative Analgesic Effect of Ultrasound Guided Erector Spinae Plane Block and Subcostal Transverse Abdominis Plane Block in Laparoscopic Cholecystectomy, Randomised Controlled Study[NCT04116008]70 participants (Actual)Interventional2019-11-10Completed
Evaluation of Postoperative Analgesic Effect of Ultrasound Guided Erector Spinae Plane Block and Oblique Subcostal Transverse Abdominis Plane Block in Laparoscopic Cholecystectomy, Randomised Controlled Study[NCT03508531]60 participants (Actual)Interventional2018-03-23Completed
A Prospective Evaluation of an Anesthesia Protocol to Reduce Post-operative and Post-discharge Nausea and Vomiting in a High Risk Orthognathic Surgery Population[NCT01592708]233 participants (Actual)Interventional2012-06-30Completed
Do Peri-operative High Doses of Intravenous Glucocorticoids Improve Short-term Functional Outcome After Direct Anterior Total Hip Arthroplasty? A Randomized, Single Surgeon, Placebo Controlled, Double Blind Study[NCT04317872]70 participants (Anticipated)Interventional2020-07-01Recruiting
The Effect of Turkish Classical Music on Postpartum Pain and Anxiety in Women Who Delivered Via Cesarean Section[NCT04111575]126 participants (Actual)Interventional2018-02-05Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Adverse Events or Outcomes Outside of Manipulations Under Anesthesia

Adverse outcomes including infection, avascular necrosis, and 90-day readmission rates (NCT05113901)
Timeframe: within 90 days after initial total knee arthroplasty

InterventionParticipants (Count of Participants)
Methylprednisolone Taper0
Placebo Taper0

Number of Participants With Complications Following Treatment

Manipulations under anesthesia (MUAs) following total knee arthroplasty surgery and treatment (NCT05113901)
Timeframe: within 90 days after initial total knee arthroplasty

InterventionParticipants (Count of Participants)
Methylprednisolone Taper0
Placebo Taper0

Patient Reported Outcome Measures: Overall Assessment of Knee 6 Weeks After Treatment

Single Assessment Numeric Evaluation (SANE), a single-question patient rating of 0-100, scoring their function to the area being treated. Zero represents a poor functional knee and 100 is the best functioning. (NCT05113901)
Timeframe: 6 weeks after treatment

Interventionscore on a scale (Mean)
Methylprednisolone Taper89.5

Patient Reported Outcome Measures: Overall Assessment of Knee 6 Weeks After Treatment

UCLA activity score, on a scale of 1 to 10 where 10 is the most active patient with examples of activities (NCT05113901)
Timeframe: 6 weeks after treatment

Interventionscore on a scale (Mean)
Methylprednisolone Taper5.25

Patient Reported Outcome Measures: Overall Assessment of Knee 6 Weeks After Treatment

VR-12: Assesses physical functioning, physical/ mental limitations. Scored as summary of mental and physical, measure in standard deviations. The scale range is 0 to 100, where a score of 100 represents the best physical and mental health and zero is the worst outcome. (NCT05113901)
Timeframe: 6 weeks after treatment

Interventionscore on a scale (Mean)
Methylprednisolone Taper50.28

Patient Reported Outcome Measures: Overall Assessment of Knee 6 Wks After Treatment

Forgotten Joint Score (FJS) is a survey scored ranging from 0 to 100, where a high score indicates a high degree of a forgetting they have an artificial joint, which is an ideal outcome. (NCT05113901)
Timeframe: 6 weeks after treatment

Interventionscore on a scale (Mean)
Methylprednisolone Taper57.82

Patient Reported Outcome Measures: Overall Assessment of Knee After Surgery and Treatment

Knee Injury and Osteoarthritis Outcome Score for Joint Replacement (KOOS JR), a survey given to patients standard of care containing 7 questions. The score ranges from 0 to 100 where zero represents total disability and 100 represents a perfect knee health. (NCT05113901)
Timeframe: 6 weeks after treatment

Interventionscore on a scale (Mean)
Methylprednisolone Taper72.12

Patient Reported Outcome Measures: Overall Assessment of Knee After Surgery and Treatment

Knee Injury and Osteoarthritis Outcome Score for Joint Replacement (KOOS JR), a survey given to patients standard of care containing 7 questions. The score ranges from 0 to 100 where zero represents total disability and 100 represents a perfect knee health. (NCT05113901)
Timeframe: pre treatment

Interventionscore on a scale (Mean)
Methylprednisolone Taper50.04

Patient Reported Outcome Measures: Overall Assessment of Knee Before Treatment

Single Assessment Numeric Evaluation (SANE), a single-question patient rating of 0-100, scoring their function to the area being treated. Zero represents a poor functional knee and 100 is the best functioning. (NCT05113901)
Timeframe: pre treatment

Interventionscore on a scale (Mean)
Methylprednisolone Taper29.5

Patient Reported Outcome Measures: Overall Assessment of Knee Before Treatment

Veterans Rand 12-Item Health Survey (VR-12), a survey of 12 questions to measure health relating to patient's quality of life. Scored as summary of mental and physical, measure in standard deviations. The scale range is 0 to 100, where a score of 100 represents the best physical and mental health and zero is the worst outcome. (NCT05113901)
Timeframe: pre treatment

Interventionscore on a scale (Mean)
Methylprednisolone Taper38.73

Patient Reported Outcome Measures: Overall Assessment of Knee Prior to Treatment

Forgotten Joint Score (FJS) is a survey scored ranging from 0 to 100, where a high score indicates a high degree of a forgetting they have an artificial joint, which is an ideal outcome. (NCT05113901)
Timeframe: pre treatment

Interventionscore on a scale (Mean)
Methylprednisolone Taper91.67

Patient Reported Outcome Measures: Overall Assessment of Knee Prior to Treatment

UCLA activity score, on a scale of 1 to 10 where 10 is the most active patient with examples of activities (NCT05113901)
Timeframe: pre treatment

Interventionscore on a scale (Mean)
Methylprednisolone Taper4.25

Patient Reported Outcome Measures: Post Treatment Pain Scores

"Knee society score (KSS); done standard of care on a scale of 0-100, where 100 means a more functional knee.~**Please note, the study was terminated early, only 4 subjects were enrolled and none were randomized to the placebo group. At 3 weeks post treatment, only 3 of the 4 subjects enrolled were still part of the study." (NCT05113901)
Timeframe: 3 weeks post treatment

Interventionscore on a scale (Mean)
Methylprednisolone Taper68.33

Patient Reported Outcome Measures: Post Treatment Pain Scores

"Knee society score (KSS); done standard of care on a scale of 0-100, where 100 means a more functional knee.~**Please note, the study was terminated early, only 4 subjects were enrolled and none were randomized to the placebo group. This is a standard of care survey available on all subjects." (NCT05113901)
Timeframe: 6 weeks post treatment

Interventionscore on a scale (Mean)
Methylprednisolone Taper78.75

Patient Reported Outcome Measures: Post Treatment Pain Scores (6 Weeks)

"Using daily defense and veterans pain rating scale (DVPRS) on a scale of 1 to 10, 10 being the worst.~Please note, only one patient made it to the 6 week post treatment mark of the 4 enrolled. The study was terminated and none of the patients were randomized to the placebo group. All other patients followed up but were not interested in continuing. No range could be provided given only one subject answered and completed this visit" (NCT05113901)
Timeframe: 6 weeks post treatment

Interventionscore on a scale (Mean)
Methylprednisolone Taper1.93

Patient Reported Outcome Measures: Pre Treatment Pain Scores Using Knee Society Scores

"Knee society score (KSS); done standard of care on a scale of 0-100, where 100 means a more functional knee~**Please note, the study was terminated early, only 4 subjects were enrolled and none were randomized to the placebo group." (NCT05113901)
Timeframe: pre treatment

Interventionscore on a scale (Mean)
Methylprednisolone Taper66.25

Patient Reported Outcome Measures:(Immediate) Post Treatment Pain Scores

"Using Daily Visual Analogue Scale (VAS) pain score, which measures intensity of pain on a scale of 0 (no pain) to 10 (worst pain possible).~**Please note, this study was terminated early, only enrolling 4 patients, none were randomized to the placebo group." (NCT05113901)
Timeframe: Days 1 through 6 following treatment

Interventionscore on a scale (Mean)
Day 1Day 2Day 3Day 4Day 5Day 6
Methylprednisolone Taper2.3331.331.331.672.3

Range of Motion in Degrees at Pre and Post Treatment

"Range of motion (ROM) from pre-treatment to six weeks following treatment. Patients started treatment after total knee replacement surgery and presented to clinic with at least one inclusion criteria to be enrolled. Range of motion in degrees is taken at each visit by a clinician (standard of care), starting at zero degrees (straight leg) to about 135 degrees. The ROM was documented as part of consenting and enrollment into study. Subjects returned to the office at 6 weeks post treatment where ROM was performed in a clinic setting once again and documented. ROM is done using a goniometer by a clinician in each clinic.~This study was terminated early, therefore of the 4 enrolled, zero were randomized to the placebo group. Only 1 of the four subjects completed the 6 weeks, however, ROM was captured on all as standard of care." (NCT05113901)
Timeframe: Baseline, Week 6 Following Treatment

InterventionRange of Motion in Degrees (Mean)
Pre treatmentPost treatment
Methylprednisolone Taper82.5112

Hospital Length of Stay

Anesthesia start time determined from anesthesia portion of the medical record. Time at which discharge order was placed will serve as time of discharge. (NCT01592708)
Timeframe: Anesthesia start time to placement of hospital discharge order - average 26 - 28 hours

Interventionhours (Median)
Intervention Cohort26.4
Comparison Cohort28.2

Post-discharge Nausea

To be assessed based on patient diary completed daily for 1 week following discharge to home from the hospital (NCT01592708)
Timeframe: 1 week from discharge from hospital

Interventionpercentage of subjects with PDN (Number)
Intervention Cohort72
Comparison Cohort60

Post-discharge Vomiting

(NCT01592708)
Timeframe: 1 week post discharge

Interventionpercentage of subjects with PDV (Number)
Intervention Cohort22
Comparison Cohort29

Post-operative Nausea

End of surgery time determined by anesthesia portion of the medical record. PONV to be assessed by review of surgeons' and nurses' notes in the medical record as well as through review of patient diaries. Vomiting constitutes a safety issue and, as such, associated adverse events will be noted. (NCT01592708)
Timeframe: End of surgery to discharge from hospital

Interventionpercentage of subjects with PON (Number)
Intervention Cohort24
Comparison Cohort70

Post-operative Vomiting

(NCT01592708)
Timeframe: End of surgery to discharge from hospital

Interventionpercentage of subjects with POV (Number)
Intervention Cohort11
Comparison Cohort28

Reviews

1 review available for metoclopramide and Pain, Postoperative

ArticleYear
Evaluation of the effective drugs for the prevention of nausea and vomiting induced by morphine used for postoperative pain: a quantitative systematic review.
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2001, Volume: 121, Issue:2

    Topics: Antiemetics; Dexamethasone; Droperidol; Humans; Metoclopramide; Morphine; Ondansetron; Pain, Postope

2001

Trials

26 trials available for metoclopramide and Pain, Postoperative

ArticleYear
Multiple Doses of Perioperative Dexamethasone Further Improve Clinical Outcomes After Total Knee Arthroplasty: A Prospective, Randomized, Controlled Study.
    The Journal of arthroplasty, 2018, Volume: 33, Issue:11

    Topics: Aged; Analgesics; Antiemetics; Arthroplasty, Replacement, Knee; Blood Glucose; C-Reactive Protein; D

2018
Multiple Doses of Perioperative Dexamethasone Further Improve Clinical Outcomes After Total Knee Arthroplasty: A Prospective, Randomized, Controlled Study.
    The Journal of arthroplasty, 2018, Volume: 33, Issue:11

    Topics: Aged; Analgesics; Antiemetics; Arthroplasty, Replacement, Knee; Blood Glucose; C-Reactive Protein; D

2018
Multiple Doses of Perioperative Dexamethasone Further Improve Clinical Outcomes After Total Knee Arthroplasty: A Prospective, Randomized, Controlled Study.
    The Journal of arthroplasty, 2018, Volume: 33, Issue:11

    Topics: Aged; Analgesics; Antiemetics; Arthroplasty, Replacement, Knee; Blood Glucose; C-Reactive Protein; D

2018
Multiple Doses of Perioperative Dexamethasone Further Improve Clinical Outcomes After Total Knee Arthroplasty: A Prospective, Randomized, Controlled Study.
    The Journal of arthroplasty, 2018, Volume: 33, Issue:11

    Topics: Aged; Analgesics; Antiemetics; Arthroplasty, Replacement, Knee; Blood Glucose; C-Reactive Protein; D

2018
Multiple Doses of Perioperative Dexamethasone Further Improve Clinical Outcomes After Total Knee Arthroplasty: A Prospective, Randomized, Controlled Study.
    The Journal of arthroplasty, 2018, Volume: 33, Issue:11

    Topics: Aged; Analgesics; Antiemetics; Arthroplasty, Replacement, Knee; Blood Glucose; C-Reactive Protein; D

2018
Multiple Doses of Perioperative Dexamethasone Further Improve Clinical Outcomes After Total Knee Arthroplasty: A Prospective, Randomized, Controlled Study.
    The Journal of arthroplasty, 2018, Volume: 33, Issue:11

    Topics: Aged; Analgesics; Antiemetics; Arthroplasty, Replacement, Knee; Blood Glucose; C-Reactive Protein; D

2018
Multiple Doses of Perioperative Dexamethasone Further Improve Clinical Outcomes After Total Knee Arthroplasty: A Prospective, Randomized, Controlled Study.
    The Journal of arthroplasty, 2018, Volume: 33, Issue:11

    Topics: Aged; Analgesics; Antiemetics; Arthroplasty, Replacement, Knee; Blood Glucose; C-Reactive Protein; D

2018
Multiple Doses of Perioperative Dexamethasone Further Improve Clinical Outcomes After Total Knee Arthroplasty: A Prospective, Randomized, Controlled Study.
    The Journal of arthroplasty, 2018, Volume: 33, Issue:11

    Topics: Aged; Analgesics; Antiemetics; Arthroplasty, Replacement, Knee; Blood Glucose; C-Reactive Protein; D

2018
Multiple Doses of Perioperative Dexamethasone Further Improve Clinical Outcomes After Total Knee Arthroplasty: A Prospective, Randomized, Controlled Study.
    The Journal of arthroplasty, 2018, Volume: 33, Issue:11

    Topics: Aged; Analgesics; Antiemetics; Arthroplasty, Replacement, Knee; Blood Glucose; C-Reactive Protein; D

2018
Metoclopramide improves the quality of tramadol PCA indistinguishable to morphine PCA: a prospective, randomized, double blind clinical comparison.
    Pain medicine (Malden, Mass.), 2013, Volume: 14, Issue:9

    Topics: Aged; Analgesia, Patient-Controlled; Analgesics; Antiemetics; Arthroplasty, Replacement, Knee; Doubl

2013
Analgesia and respiratory function after laparoscopic cholecystectomy in patients receiving ultrasound-guided bilateral oblique subcostal transversus abdominis plane block: a randomized double-blind study.
    Medical science monitor : international medical journal of experimental and clinical research, 2015, May-07, Volume: 21

    Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; C

2015
Analgesia and respiratory function after laparoscopic cholecystectomy in patients receiving ultrasound-guided bilateral oblique subcostal transversus abdominis plane block: a randomized double-blind study.
    Medical science monitor : international medical journal of experimental and clinical research, 2015, May-07, Volume: 21

    Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; C

2015
Analgesia and respiratory function after laparoscopic cholecystectomy in patients receiving ultrasound-guided bilateral oblique subcostal transversus abdominis plane block: a randomized double-blind study.
    Medical science monitor : international medical journal of experimental and clinical research, 2015, May-07, Volume: 21

    Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; C

2015
Analgesia and respiratory function after laparoscopic cholecystectomy in patients receiving ultrasound-guided bilateral oblique subcostal transversus abdominis plane block: a randomized double-blind study.
    Medical science monitor : international medical journal of experimental and clinical research, 2015, May-07, Volume: 21

    Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; C

2015
Analgesia and respiratory function after laparoscopic cholecystectomy in patients receiving ultrasound-guided bilateral oblique subcostal transversus abdominis plane block: a randomized double-blind study.
    Medical science monitor : international medical journal of experimental and clinical research, 2015, May-07, Volume: 21

    Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; C

2015
Analgesia and respiratory function after laparoscopic cholecystectomy in patients receiving ultrasound-guided bilateral oblique subcostal transversus abdominis plane block: a randomized double-blind study.
    Medical science monitor : international medical journal of experimental and clinical research, 2015, May-07, Volume: 21

    Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; C

2015
Analgesia and respiratory function after laparoscopic cholecystectomy in patients receiving ultrasound-guided bilateral oblique subcostal transversus abdominis plane block: a randomized double-blind study.
    Medical science monitor : international medical journal of experimental and clinical research, 2015, May-07, Volume: 21

    Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; C

2015
Analgesia and respiratory function after laparoscopic cholecystectomy in patients receiving ultrasound-guided bilateral oblique subcostal transversus abdominis plane block: a randomized double-blind study.
    Medical science monitor : international medical journal of experimental and clinical research, 2015, May-07, Volume: 21

    Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; C

2015
Analgesia and respiratory function after laparoscopic cholecystectomy in patients receiving ultrasound-guided bilateral oblique subcostal transversus abdominis plane block: a randomized double-blind study.
    Medical science monitor : international medical journal of experimental and clinical research, 2015, May-07, Volume: 21

    Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; C

2015
Analgesia and respiratory function after laparoscopic cholecystectomy in patients receiving ultrasound-guided bilateral oblique subcostal transversus abdominis plane block: a randomized double-blind study.
    Medical science monitor : international medical journal of experimental and clinical research, 2015, May-07, Volume: 21

    Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; C

2015
Analgesia and respiratory function after laparoscopic cholecystectomy in patients receiving ultrasound-guided bilateral oblique subcostal transversus abdominis plane block: a randomized double-blind study.
    Medical science monitor : international medical journal of experimental and clinical research, 2015, May-07, Volume: 21

    Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; C

2015
Analgesia and respiratory function after laparoscopic cholecystectomy in patients receiving ultrasound-guided bilateral oblique subcostal transversus abdominis plane block: a randomized double-blind study.
    Medical science monitor : international medical journal of experimental and clinical research, 2015, May-07, Volume: 21

    Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; C

2015
Analgesia and respiratory function after laparoscopic cholecystectomy in patients receiving ultrasound-guided bilateral oblique subcostal transversus abdominis plane block: a randomized double-blind study.
    Medical science monitor : international medical journal of experimental and clinical research, 2015, May-07, Volume: 21

    Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; C

2015
Analgesia and respiratory function after laparoscopic cholecystectomy in patients receiving ultrasound-guided bilateral oblique subcostal transversus abdominis plane block: a randomized double-blind study.
    Medical science monitor : international medical journal of experimental and clinical research, 2015, May-07, Volume: 21

    Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; C

2015
Analgesia and respiratory function after laparoscopic cholecystectomy in patients receiving ultrasound-guided bilateral oblique subcostal transversus abdominis plane block: a randomized double-blind study.
    Medical science monitor : international medical journal of experimental and clinical research, 2015, May-07, Volume: 21

    Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; C

2015
Analgesia and respiratory function after laparoscopic cholecystectomy in patients receiving ultrasound-guided bilateral oblique subcostal transversus abdominis plane block: a randomized double-blind study.
    Medical science monitor : international medical journal of experimental and clinical research, 2015, May-07, Volume: 21

    Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; C

2015
Effects of intraperitoneal levobupivacaine on pain after laparoscopic cholecystectomy: a prospective, randomized, double-blinded study.
    Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology, 2009, Volume: 21, Issue:4

    Topics: Adult; Anesthetics, Local; Bupivacaine; Cholecystectomy; Double-Blind Method; Female; Humans; Laparo

2009
Antiemetic efficacy of metoclopramide and diphenhydramine added to patient-controlled morphine analgesia: a randomised controlled trial.
    European journal of anaesthesiology, 2010, Volume: 27, Issue:12

    Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Antiemetics; Dexamethasone; Diphenhydramin

2010
Effects of ramosetron and dexamethasone on postoperative nausea, vomiting, pain, and shivering in female patients undergoing thyroid surgery.
    Journal of anesthesia, 2013, Volume: 27, Issue:1

    Topics: Adult; Aged; Anesthesia, General; Antiemetics; Benzimidazoles; Dexamethasone; Female; Humans; Metocl

2013
[Postoperative pain therapy in urology. A prospective study].
    Der Urologe. Ausg. A, 2002, Volume: 41, Issue:3

    Topics: Analgesia, Patient-Controlled; Dipyrone; Dose-Response Relationship, Drug; Drug Administration Sched

2002
Preventing prolonged post-operative ileus in gastric cancer patients undergoing gastrectomy and intra-peritoneal chemotherapy.
    World journal of gastroenterology, 2005, Aug-21, Volume: 11, Issue:31

    Topics: Adult; Aged; Dopamine Antagonists; Electrolytes; Female; Gastrectomy; Humans; Ileus; Male; Metoclopr

2005
The effects of preoperative rofecoxib, metoclopramide, dexamethasone, and ondansetron on postoperative pain and nausea in patients undergoing elective laparoscopic cholecystectomy.
    Surgical endoscopy, 2007, Volume: 21, Issue:10

    Topics: Antiemetics; Cholecystectomy, Laparoscopic; Cyclooxygenase 2 Inhibitors; Dexamethasone; Double-Blind

2007
The impact of music on postoperative pain and anxiety following cesarean section.
    Middle East journal of anaesthesiology, 2007, Volume: 19, Issue:3

    Topics: Adult; Analgesics, Opioid; Anesthesia, General; Anti-Anxiety Agents; Antiemetics; Anxiety; Cesarean

2007
Antiemetic efficacy of a droperidol-morphine combination in patient-controlled analgesia.
    Journal of clinical anesthesia, 1995, Volume: 7, Issue:2

    Topics: Adolescent; Adult; Analgesia, Patient-Controlled; Dose-Response Relationship, Drug; Double-Blind Met

1995
Rectal indomethacin for analgesia after appendicectomy in children.
    Anaesthesia and intensive care, 1994, Volume: 22, Issue:3

    Topics: Administration, Rectal; Analgesia; Analgesia, Patient-Controlled; Appendectomy; Child; Double-Blind

1994
Evaluation of the analgesic effect of metoclopramide after opioid-free analgesia.
    British journal of anaesthesia, 1993, Volume: 70, Issue:6

    Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Anesthesia, General; Arthroscopy; Double-Blind Met

1993
Analgesic action of metoclopramide in prosthetic hip surgery.
    Acta anaesthesiologica Scandinavica, 1993, Volume: 37, Issue:1

    Topics: Aged; Anesthesia, Spinal; Bupivacaine; Double-Blind Method; Female; Hip Prosthesis; Humans; Infusion

1993
Comparison of ondansetron and metoclopramide for the prevention of post-operative nausea and vomiting after major gynaecological surgery.
    European journal of anaesthesiology, 1996, Volume: 13, Issue:5

    Topics: Adolescent; Adult; Analgesics, Opioid; Antiemetics; Double-Blind Method; Female; Humans; Hysterectom

1996
Comparison of metoclopramide and ondansetron for the prevention of nausea and vomiting after intrathecal morphine.
    European journal of anaesthesiology, 1997, Volume: 14, Issue:2

    Topics: Aged; Analgesics, Opioid; Antiemetics; Blood Pressure; Double-Blind Method; Female; Hip; Humans; Inj

1997
Ondansetron is more effective than metoclopramide for the treatment of opioid-induced emesis in post-surgical adult patients. Ondansetron OIE Post-Surgical Study Group.
    European journal of anaesthesiology, 1999, Volume: 16, Issue:10

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Antiemetics; Double-Blind Method; Fe

1999
Placebo-controlled comparison of dolasetron and metoclopramide in preventing postoperative nausea and vomiting in patients undergoing hysterectomy.
    European journal of anaesthesiology, 2001, Volume: 18, Issue:4

    Topics: Antiemetics; Blood Loss, Surgical; Droperidol; Female; Humans; Hysterectomy; Indoles; Metoclopramide

2001
Low-dose dexamethasone reduces nausea and vomiting after epidural morphine: a comparison of metoclopramide with saline.
    Journal of clinical anesthesia, 2002, Volume: 14, Issue:1

    Topics: Adult; Analgesia, Epidural; Analgesics, Opioid; Antiemetics; Dexamethasone; Double-Blind Method; Fem

2002
The morphine-sparing effect of metoclopramide on postoperative laparoscopic tubal ligation patients.
    AANA journal, 2002, Volume: 70, Issue:1

    Topics: Adult; Analgesics, Opioid; Dopamine Antagonists; Double-Blind Method; Female; Humans; Laparoscopy; M

2002
Incidence and severity of postoperative nausea and vomiting are similar after metoclopramide 20 mg and ondansetron 8 mg given by the end of laparoscopic cholecystectomies.
    Acta anaesthesiologica Scandinavica, 2002, Volume: 46, Issue:1

    Topics: Anesthesia, General; Antiemetics; Cholecystectomy, Laparoscopic; Double-Blind Method; Female; Humans

2002
Oral ondansetron, tropisetron or metoclopramide to prevent postoperative nausea and vomiting: a comparison in high-risk patients undergoing thyroid or parathyroid surgery.
    Acta anaesthesiologica Scandinavica, 2002, Volume: 46, Issue:5

    Topics: Adult; Analgesics, Opioid; Antiemetics; Double-Blind Method; Female; Humans; Indoles; Male; Metoclop

2002
Lignocaine vs bupivacaine in prominent ear correction: a controlled trial.
    British journal of plastic surgery, 1992, Volume: 45, Issue:7

    Topics: Acetaminophen; Adolescent; Adult; Anesthesia, General; Anesthesia, Local; Bupivacaine; Child; Child,

1992
Outpatient cholecystectomy simulated in an inpatient population.
    The American surgeon, 1991, Volume: 57, Issue:1

    Topics: Abdomen; Adult; Age Factors; Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Analgesics; An

1991
A comparison of rectal indomethacin with placebo for pain relief following spinal surgery.
    Anaesthesia and intensive care, 1991, Volume: 19, Issue:1

    Topics: Administration, Rectal; Bleeding Time; Blood Loss, Surgical; Diazepam; Double-Blind Method; Drinking

1991
The effect of metoclopramide on the absorption of oral controlled release morphine.
    British journal of clinical pharmacology, 1988, Volume: 25, Issue:4

    Topics: Administration, Oral; Aged; Delayed-Action Preparations; Double-Blind Method; Drug Interactions; Fem

1988

Other Studies

9 other studies available for metoclopramide and Pain, Postoperative

ArticleYear
Analgesic effects of sufentanil in combination with flurbiprofen axetil and dexmedetomidine after open gastrointestinal tumor surgery: a retrospective study.
    BMC anesthesiology, 2022, 04-29, Volume: 22, Issue:1

    Topics: Analgesics; Analgesics, Opioid; Dexmedetomidine; Flurbiprofen; Gastrointestinal Neoplasms; Humans; M

2022
Methylprednisolone reduces postoperative nausea in total knee and hip arthroplasty.
    Journal of clinical pharmacy and therapeutics, 2010, Volume: 35, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antiemetics; Arthroplasty, Replacement, Hip; Arthroplasty, Replaceme

2010
Utilization of PCIA (patient-controlled intravenous analgesia) for postoperative analgesia of spine fusion.
    The Tokai journal of experimental and clinical medicine, 2003, Volume: 28, Issue:1

    Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Antiemetics; Female; Humans; Injections, In

2003
Local anesthesia use for laparoscopic cholecystectomy.
    World journal of surgery, 2004, Volume: 28, Issue:8

    Topics: Adult; Aged; Analgesics; Anesthesia, Local; Antiemetics; Bupivacaine; Cholecystectomy, Laparoscopic;

2004
Is metoclopramide an alternative to tramadol in management of post-operative pain? An experimental study.
    Journal of veterinary medicine. A, Physiology, pathology, clinical medicine, 2005, Volume: 52, Issue:5

    Topics: Analgesics, Opioid; Animals; Dopamine Antagonists; Male; Metoclopramide; Pain Measurement; Pain, Pos

2005
[Studies on changes of the plasma prolactin, growth hormone and ACTH levels following surgical stress and epidural micro-injections of morphine hydrochloride as a postoperative analgesic method].
    Nihon Sanka Fujinka Gakkai zasshi, 1982, Volume: 34, Issue:10

    Topics: Adrenocorticotropic Hormone; Adult; Analgesia; Epidural Space; Growth Hormone; Humans; Metoclopramid

1982
Treatment of migraine headache after ocular surgery with intravenous metoclopramide hydrochloride.
    American journal of ophthalmology, 1996, Volume: 121, Issue:1

    Topics: Adult; Cataract Extraction; Dopamine Antagonists; Female; Humans; Injections, Intravenous; Lenses, I

1996
Naloxone-resistant respiratory depression and neurological eye symptoms after intrathecal morphine.
    Anesthesia and analgesia, 2000, Volume: 91, Issue:2

    Topics: Aged; Analgesics, Opioid; Antiemetics; Depression, Chemical; Drug Interactions; Drug Resistance; Eye

2000
[Propofol anesthesia for ambulatory surgery in adults].
    Masui. The Japanese journal of anesthesiology, 2000, Volume: 49, Issue:10

    Topics: Adult; Ambulatory Surgical Procedures; Anesthesia, General; Anesthesia, Local; Fentanyl; Flurbiprofe

2000