metoclopramide has been researched along with Muscle Relaxation in 14 studies
Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.
metoclopramide : A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Although metoclopramide increased LES and barrier pressures, it did not attenuate cricoid pressure-induced relaxation of the LES and barrier pressures and thus seems to have no value in preventing gastroesophageal reflux during cricoid pressure." | 3.74 | Metoclopramide does not attenuate cricoid pressure-induced relaxation of the lower esophageal sphincter in awake volunteers. ( Bruninga, KW; Dodlapatii, J; Joseph, NJ; Salem, MR, 2008) |
| "Metoclopramide is a useful agent during gastroscopic examination in cases of spasmodic pylorus." | 2.64 | The effect of metoclopramide (Primperan) on the pyloric sphincter during gastroscopic examination. A double blind investigation versus placebo. ( Furugård, K; Hradsky, M, 1978) |
| "Magnesium sulfate was more potent for prolonging myometrial contractile interval than reducing contractile force." | 1.40 | Relaxant effects of metoclopramide and magnesium sulfate on isolated pregnant myometrium: an in vitro study. ( Du, Y; Lin, XM; Ma, YS; Ni, J; Tang, YY; Zhou, J, 2014) |
| "Pretreatment with metoclopramide or with pimozide shifted the volume-pressure diagram of the stomach to the left; that is, at any given volume the pressure was greater after than before these drugs." | 1.26 | Dopamine as a possible neurotransmitter in gastric relaxation. ( Valenzuela, JE, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (50.00) | 18.7374 |
| 1990's | 4 (28.57) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tang, YY | 1 |
| Du, Y | 1 |
| Ni, J | 1 |
| Ma, YS | 1 |
| Lin, XM | 1 |
| Zhou, J | 1 |
| Salem, MR | 1 |
| Bruninga, KW | 1 |
| Dodlapatii, J | 1 |
| Joseph, NJ | 1 |
| Saito, M | 1 |
| Shibata, O | 1 |
| Yamaguchi, M | 1 |
| Yoshimura, M | 1 |
| Makita, T | 1 |
| Harada, N | 1 |
| Niwa, M | 1 |
| Sumikawa, K | 1 |
| Costall, B | 1 |
| Naylor, RJ | 1 |
| Tan, CC | 1 |
| Buchheit, KH | 1 |
| Buhl, T | 1 |
| Desai, KM | 1 |
| Warner, TD | 1 |
| Vane, JR | 1 |
| Eglen, RM | 1 |
| Bley, K | 1 |
| Bonhaus, DW | 1 |
| Clark, RD | 1 |
| Hegde, SS | 1 |
| Johnson, LG | 1 |
| Leung, E | 1 |
| Wong, EH | 1 |
| Hayakawa, T | 1 |
| Arakawa, T | 1 |
| Kase, Y | 1 |
| Akiyama, S | 1 |
| Ishige, A | 1 |
| Takeda, S | 1 |
| Sasaki, H | 1 |
| Uno, H | 1 |
| Fukuda, T | 1 |
| Higuchi, K | 1 |
| Kobayashi, K | 1 |
| Valenzuela, JE | 1 |
| Hradsky, M | 1 |
| Furugård, K | 1 |
| Brodde, OE | 1 |
| Schemuth, W | 1 |
| Lombardi, DM | 1 |
| Grous, M | 1 |
| Fine, CF | 1 |
| Barone, FC | 1 |
| Fowler, PJ | 1 |
| Phyall, WB | 1 |
| Rush, JA | 1 |
| Ormsbee, HS | 1 |
| Mori, M | 1 |
| Hoshino, Y | 1 |
| Obara, H | 1 |
| Iwai, S | 1 |
| Schuurkes, JA | 1 |
| Helsen, LF | 1 |
| Van Nueten, JM | 1 |
1 trial available for metoclopramide and Muscle Relaxation
| Article | Year |
|---|---|
The effect of metoclopramide (Primperan) on the pyloric sphincter during gastroscopic examination. A double blind investigation versus placebo.
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Gastroscopy; Humans; Male; Metoc | 1978 |
13 other studies available for metoclopramide and Muscle Relaxation
| Article | Year |
|---|---|
Relaxant effects of metoclopramide and magnesium sulfate on isolated pregnant myometrium: an in vitro study.
Topics: Adult; Cabergoline; Dopamine Agonists; Dopamine Antagonists; Ergolines; Female; Humans; In Vitro Tec | 2014 |
Metoclopramide does not attenuate cricoid pressure-induced relaxation of the lower esophageal sphincter in awake volunteers.
Topics: Adult; Cricoid Cartilage; Esophageal Sphincter, Lower; Esophageal Sphincter, Upper; Gastroesophageal | 2008 |
Metoclopramide causes airway smooth muscle relaxation through inhibition of muscarinic M3 receptor in the rat trachea.
Topics: Animals; Antiemetics; Carbachol; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Male; Metoclopra | 2004 |
Neuronally mediated contraction responses of guinea-pig stomach smooth muscle preparations: modification by benzamide derivatives does not reflect a dopamine antagonist action.
Topics: Animals; Benzamides; Domperidone; Electric Stimulation; Guinea Pigs; Haloperidol; In Vitro Technique | 1984 |
Stimulant effects of 5-hydroxytryptamine on guinea pig stomach preparations in vitro.
Topics: 4-Aminobenzoic Acid; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Atropine; Benzamides; Binding | 1994 |
5-HT3 receptors do not mediate vagally-induced relaxation or contraction of the isolated stomach of the guinea-pig.
Topics: Animals; Dimethylphenylpiperazinium Iodide; Electric Stimulation; In Vitro Techniques; Male; Metoclo | 1994 |
RS 23597-190: a potent and selective 5-HT4 receptor antagonist.
Topics: 4-Aminobenzoic Acid; Aminobenzoates; Animals; Blood Pressure; Electrophysiology; Female; Guinea Pigs | 1993 |
Liu-Jun-Zi-Tang, a kampo medicine, promotes adaptive relaxation in isolated guinea pig stomachs.
Topics: Adaptation, Physiological; Animals; Arginine; Cisapride; Drug Evaluation, Preclinical; Drugs, Chines | 1999 |
Dopamine as a possible neurotransmitter in gastric relaxation.
Topics: Animals; Dogs; Dopamine; Dopamine Antagonists; Gastrointestinal Motility; Metoclopramide; Muscle Con | 1976 |
Specific antagonism by metoclopramide of dopamine-induced relaxation on isolated rabbit mesenteric arteries contracted with prostaglandin F2alpha.
Topics: Animals; Dopamine; Dopamine Antagonists; Female; In Vitro Techniques; Isoproterenol; Male; Mesenteri | 1979 |
DA1 receptor mediates dopamine-induced relaxation of opossum lower esophageal sphincter in vitro.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Aporphines; Benzaz | 1986 |
Maturation-related changes in dopamine-induced relaxation of isolated rabbit pulmonary artery.
Topics: Aging; Animals; Dopamine; Dose-Response Relationship, Drug; Female; Flupenthixol; Male; Metocloprami | 1988 |
A comparative study on the effects of domperidone, metoclopramide, clebopride and trimebutine on the gastro-duodenal preparation of the guinea pig.
Topics: Animals; Benzamides; Benzoates; Domperidone; Drug Antagonism; Duodenum; Female; Gastrointestinal Mot | 1985 |