metoclopramide has been researched along with Intestinal Obstruction in 30 studies
Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.
metoclopramide : A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.
Intestinal Obstruction: Any impairment, arrest, or reversal of the normal flow of INTESTINAL CONTENTS toward the ANAL CANAL.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metoclopramide was intravenously administered every 8 hours from the completion of surgery until a solid food diet was able to be tolerated." | 2.67 | Does metoclopramide reduce the length of ileus after colorectal surgery? A prospective randomized trial. ( Cheape, JD; Jagelman, DG; James, K; Wexner, SD, 1991) |
| "Metoclopramide or placebo was administered postoperatively in a randomized, double-blind fashion to 115 patients undergoing laparotomy." | 2.65 | The effects of metoclopramide on postoperative ileus. A randomized double-blind study. ( Barnett, SM; Boyle, LP; Brinner, RA; Davidson, ED; Hersh, T, 1979) |
| "Metoclopramide was the drug of choice in treating PIMBO, whereas haloperidol and hyoscine butylbromide (HB) were the preferred drugs as the severity of bowel obstruction increased." | 1.40 | Nonopioid pharmacological management of malignant bowel obstruction: a New Zealand-wide survey. ( Brosnan, EA; Landman, WJ; Mittal, A; Mittal, DL, 2014) |
| "Eleven advanced cancer patients affected by malignant bowel obstruction (MBO) were treated at home with a combination of octreotide, metoclopramide, morphine, and dexamethasone." | 1.37 | Can malignant bowel obstruction in advanced cancer patients be treated at home? ( Aielli, F; Ficorella, C; Galletti, B; Porzio, G; Shoja E Razavi, G; Verna, L, 2011) |
| "Metoclopramide has the greatest evidence for efficacy followed by phenothiazines and tropisetron." | 1.36 | Nausea and vomiting in advanced cancer. ( Ang, SK; Davis, MP; Shoemaker, LK, 2010) |
| "Early NGT removal combined with metoclopramide after postchemotherapy RPLND allowed earlier diet tolerance and shortened hospital stays without increased complications." | 1.31 | Early nasogastric tube removal combined with metoclopramide after postchemotherapy retroperitoneal lymph node dissection for metastatic testicular nonseminomatous germ cell tumor. ( Davis, JW; Donat, SM; Doviak, MJ; Pisters, LL, 2002) |
| "Intestinal obstruction is a relatively common clinical problem in patients with advanced cancer, particularly those with colorectal and ovarian tumours." | 1.28 | Non-operative management of malignant intestinal obstruction. ( Elder, P; Isbister, WH; Symons, L, 1990) |
| "Yohimbine was more effective and the addition of bethanechol produced a little extra propulsive action." | 1.27 | Pathophysiology of equine postoperative ileus: effect of adrenergic blockade, parasympathetic stimulation and metoclopramide in an experimental model. ( Gerring, EE; Hunt, JM, 1986) |
| "Magnesium deficiency was present in seven patients and its correction resulted in amelioration of the symptom complex." | 1.26 | Chronic intestinal pseudo-obstruction. ( Brandenburg, D; Brooks, WS; Hersh, T; Hirsh, EH, 1981) |
| "Metoclopramide is a drug that increases gastrointestinal motility, has few significant side effects, and may be of use in decreasing the ileus associated with acute spinal cord injuries." | 1.26 | Prolonged ileus with acute spinal cord injury responding to metaclopramide. ( Fenzl, TC; Miller, F, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (43.33) | 18.7374 |
| 1990's | 6 (20.00) | 18.2507 |
| 2000's | 5 (16.67) | 29.6817 |
| 2010's | 5 (16.67) | 24.3611 |
| 2020's | 1 (3.33) | 2.80 |
| Authors | Studies |
|---|---|
| Wey, W | 1 |
| Mian, M | 1 |
| Calabrese, R | 1 |
| Hansen, E | 1 |
| Walter, M | 1 |
| Wang, C | 1 |
| Miller, A | 1 |
| Case, AA | 1 |
| Mittal, DL | 1 |
| Mittal, A | 1 |
| Brosnan, EA | 1 |
| Landman, WJ | 1 |
| Berger, J | 1 |
| Lester, P | 1 |
| Rodrigues, L | 1 |
| Bafuma, PJ | 1 |
| Nandi, A | 1 |
| Weisberg, M | 1 |
| Stamper, MA | 1 |
| Spicer, CW | 1 |
| Neiffer, DL | 1 |
| Mathews, KS | 1 |
| Fleming, GJ | 1 |
| Ang, SK | 1 |
| Shoemaker, LK | 1 |
| Davis, MP | 1 |
| Porzio, G | 1 |
| Aielli, F | 1 |
| Verna, L | 1 |
| Galletti, B | 1 |
| Shoja E Razavi, G | 1 |
| Ficorella, C | 1 |
| Albibi, R | 1 |
| McCallum, RW | 1 |
| Lykkegaard-Nielsen, M | 1 |
| Madsen, PV | 1 |
| Nielsen, OV | 1 |
| Lindor, KD | 1 |
| Malagelada, JR | 1 |
| Shangaĭ, VA | 1 |
| Lebedinets, VN | 1 |
| Hirsh, EH | 1 |
| Brandenburg, D | 1 |
| Hersh, T | 2 |
| Brooks, WS | 1 |
| Miller, F | 1 |
| Fenzl, TC | 1 |
| Dart, AJ | 2 |
| Peauroi, JR | 1 |
| Hodgson, DR | 2 |
| Pascoe, JR | 1 |
| Resnick, J | 1 |
| Greenwald, DA | 1 |
| Brandt, LJ | 1 |
| De Winter, BY | 1 |
| Boeckxstaens, GE | 1 |
| De Man, JG | 1 |
| Moreels, TG | 1 |
| Schuurkes, JA | 1 |
| Peeters, TL | 1 |
| Herman, AG | 1 |
| Pelckmans, PA | 1 |
| Hawasli, A | 1 |
| Thusay, M | 1 |
| Elskens, DP | 1 |
| Gehring, RL | 1 |
| Sidhu, KS | 1 |
| Moreale, VM | 1 |
| Lloyd, LL | 1 |
| Nieto, JE | 1 |
| Rakestraw, PC | 1 |
| Snyder, JR | 1 |
| Vatistas, NJ | 1 |
| Seta, ML | 1 |
| Kale-Pradhan, PB | 1 |
| Davis, JW | 1 |
| Pisters, LL | 1 |
| Doviak, MJ | 1 |
| Donat, SM | 1 |
| Lipton, AB | 1 |
| Knauer, CM | 1 |
| Davidson, ED | 1 |
| Brinner, RA | 1 |
| Barnett, SM | 1 |
| Boyle, LP | 1 |
| Zastrow, R | 1 |
| Cheape, JD | 1 |
| Wexner, SD | 1 |
| James, K | 1 |
| Jagelman, DG | 1 |
| Isbister, WH | 1 |
| Elder, P | 1 |
| Symons, L | 1 |
| Jepsen, S | 1 |
| Klaerke, A | 1 |
| Nielsen, PH | 1 |
| Simonsen, O | 1 |
| Kilam, SK | 1 |
| Cohen, MM | 1 |
| Gerring, EE | 1 |
| Hunt, JM | 1 |
| Garewal, HS | 1 |
| Dalton, WS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Mosapride on Postoperative Ileus in Patients Undergoing Colorectal Surgery[NCT02056405] | Phase 4 | 90 participants (Anticipated) | Interventional | 2015-12-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for metoclopramide and Intestinal Obstruction
| Article | Year |
|---|---|
Metoclopramide: pharmacology and clinical application.
Topics: Anorexia Nervosa; Antiemetics; Diabetes Mellitus; Dopamine Antagonists; Endocrine Glands; Gastric Em | 1983 |
Symposium on upper gastrointestinal motility disorders. Gastric motor disorders: an overview.
Topics: Electrophysiology; Gastric Emptying; Gastrointestinal Motility; Humans; Intestinal Obstruction; Mano | 1984 |
Delayed gastric emptying and postoperative ileus after nongastric abdominal surgery: part II.
Topics: Abdomen; Cisapride; Dopamine Antagonists; Erythromycin; Gastric Emptying; Gastrointestinal Agents; H | 1997 |
Role of prokinetic drugs for treatment of postoperative ileus in the horse.
Topics: Adrenergic Antagonists; Anesthetics, Local; Animals; Anti-Bacterial Agents; Cholinergic Agonists; Ci | 1998 |
5 trials available for metoclopramide and Intestinal Obstruction
| Article | Year |
|---|---|
Ceruletide vs. metoclopramide in postoperative intestinal paralysis. A double-blind clinical trial.
Topics: Adult; Aged; Ceruletide; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Intestinal O | 1984 |
Pseudo-obstruction of the bowel. Therapeutic trial of metoclopramide.
Topics: Adult; Clinical Trials as Topic; Female; Humans; Intestinal Obstruction; Metoclopramide; Placebos | 1977 |
The effects of metoclopramide on postoperative ileus. A randomized double-blind study.
Topics: Adult; Aged; Digestive System Surgical Procedures; Female; Gastrointestinal Motility; Humans; Intest | 1979 |
Does metoclopramide reduce the length of ileus after colorectal surgery? A prospective randomized trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Clinical Protocols; Colorectal Surgery; Double-Blind Met | 1991 |
Negative effect of Metoclopramide in postoperative adynamic ileus. A prospective, randomized, double blind study.
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Flatulence; Humans; Intestinal O | 1986 |
21 other studies available for metoclopramide and Intestinal Obstruction
| Article | Year |
|---|---|
Palliative Medical Management of Inoperable Malignant Bowel Obstruction With "Triple Therapy": Dexamethasone, Octreotide, and Metoclopramide.
Topics: Dexamethasone; Humans; Intestinal Obstruction; Metoclopramide; Octreotide; Palliative Care; Retrospe | 2021 |
Nonopioid pharmacological management of malignant bowel obstruction: a New Zealand-wide survey.
Topics: Aged; Aged, 80 and over; Antiemetics; Cholinergic Antagonists; Dexamethasone; Enema; Female; Gastroi | 2014 |
Medical Therapy of Malignant Bowel Obstruction With Octreotide, Dexamethasone, and Metoclopramide.
Topics: Abdominal Neoplasms; Adult; Aged; Aged, 80 and over; Colonic Diseases; Dexamethasone; Drug Therapy, | 2016 |
Opiate refractory pain from an intestinal obstruction responsive to an intravenous lidocaine infusion.
Topics: Abdominal Pain; Analgesics, Opioid; Anesthetics, Local; Antiemetics; Colostomy; Diagnosis, Different | 2015 |
Morbidity in a juvenile green sea turtle (Chelonia mydas) due to ocean-borne plastic.
Topics: Animals; Defecation; Gastrointestinal Agents; Intestinal Obstruction; Lubricants; Metoclopramide; Mi | 2009 |
Nausea and vomiting in advanced cancer.
Topics: Algorithms; Antiemetics; Causality; Decision Trees; Drug Therapy, Combination; Evidence-Based Medici | 2010 |
Can malignant bowel obstruction in advanced cancer patients be treated at home?
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Antiemetics; Dexamethasone; Drug Therapy, Combin | 2011 |
[Pharmacological regulation of intestinal motility in patients with injuries].
Topics: Adolescent; Adult; Gastrointestinal Motility; Humans; Intestinal Obstruction; Intestinal Pseudo-Obst | 1984 |
Chronic intestinal pseudo-obstruction.
Topics: Adult; Aged; Celiac Disease; Chronic Disease; Female; Humans; Intestinal Obstruction; Intestinal Pse | 1981 |
Prolonged ileus with acute spinal cord injury responding to metaclopramide.
Topics: Acute Disease; Adult; Humans; Intestinal Obstruction; Male; Metoclopramide; Quadriplegia; Spinal Cor | 1981 |
Efficacy of metoclopramide for treatment of ileus in horses following small intestinal surgery: 70 cases (1989-1992).
Topics: Anastomosis, Surgical; Animals; Cecostomy; Dopamine Antagonists; Drainage; Horse Diseases; Horses; I | 1996 |
Effect of different prokinetic agents and a novel enterokinetic agent on postoperative ileus in rats.
Topics: Animals; Cisapride; Dopamine Antagonists; Erythromycin; Gastrointestinal Agents; Granisetron; Intest | 1999 |
Laparoscopic anterior lumbar fusion.
Topics: Adult; Dopamine Antagonists; Feasibility Studies; Female; Humans; Intestinal Obstruction; Laparoscop | 2000 |
In vitro effects of erythromycin, lidocaine, and metoclopramide on smooth muscle from the pyloric antrum, proximal portion of the duodenum, and middle portion of the jejunum of horses.
Topics: Animals; Anti-Arrhythmia Agents; Dopamine Antagonists; Duodenum; Erythromycin; Gastrointestinal Agen | 2000 |
Efficacy of metoclopramide in postoperative ileus after exploratory laparotomy.
Topics: Adult; Aged; Aged, 80 and over; Antiemetics; Diagnostic Techniques, Surgical; Diet; Female; Humans; | 2001 |
Early nasogastric tube removal combined with metoclopramide after postchemotherapy retroperitoneal lymph node dissection for metastatic testicular nonseminomatous germ cell tumor.
Topics: Adult; Antiemetics; Antineoplastic Agents; Case-Control Studies; Device Removal; Diet; Humans; Intes | 2002 |
[Acute pancreatitis--pancreas necrosis].
Topics: Acute Disease; Aprotinin; Atropine; Drainage; Fasting; Humans; Intestinal Obstruction; Metoclopramid | 1975 |
Non-operative management of malignant intestinal obstruction.
Topics: Adult; Aged; Colorectal Neoplasms; Drug Combinations; Female; Humans; Infusions, Intravenous; Intest | 1990 |
Small-bowel obstruction after conservative treatment of gastric bezoar.
Topics: Adult; Bezoars; Female; Humans; Ileal Diseases; Intestinal Obstruction; Male; Metoclopramide; Middle | 1986 |
Pathophysiology of equine postoperative ileus: effect of adrenergic blockade, parasympathetic stimulation and metoclopramide in an experimental model.
Topics: Animals; Bethanechol Compounds; Gastrointestinal Motility; Horse Diseases; Horses; Intestinal Obstru | 1986 |
Metoclopramide in vincristine-induced ileus.
Topics: Aged; Constipation; Gastrointestinal Motility; Humans; Intestinal Obstruction; Leukemia, Lymphoid; L | 1985 |